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FAT domain of focal adhesion kinase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Four-helical up-and-down bundle [ 47161] (28)
Superfamily:   FAT domain of focal adhesion kinase [ 68993]
Families:   FAT domain of focal adhesion kinase [ 68994]


Superfamily statistics
Genomes (128) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 357 359 7
Proteins 356 358 7


Functional annotation
General category Regulation
Detailed category Kinases/phosphatases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.000001917 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.0000000000004804 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.0000002529 Least Informative Direct
Biological Process (BP) localization 0.00003909 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.0000002309 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.01469 Least Informative Inherited
Biological Process (BP) response to stimulus 0.2482 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.05327 Least Informative Inherited
Biological Process (BP) developmental process 0.03642 Least Informative Inherited
Biological Process (BP) system process 0.0000009426 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) organelle organization 0.0001562 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.000000000001075 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0.000000000000003755 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.0001488 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.00001716 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0.00000000000001264 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.000000003519 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.00000004819 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.000000000000007347 Moderately Informative Direct
Biological Process (BP) cellular localization 0.00003189 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.0000001471 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.01282 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.04292 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.01013 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.02919 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.3235 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.2644 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.1235 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.00556 Moderately Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0 Informative Direct
Biological Process (BP) cytoskeleton organization 0.000000000009067 Informative Direct
Biological Process (BP) synaptic transmission 0 Informative Direct
Biological Process (BP) regulation of intracellular protein kinase cascade 0 Informative Direct
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0.000009695 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0 Informative Direct
Biological Process (BP) regulation of growth 0.0000000001967 Informative Direct
Biological Process (BP) regulation of locomotion 0.00003394 Informative Direct
Biological Process (BP) regulation of kinase activity 0 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.0001019 Informative Direct
Biological Process (BP) generation of neurons 0.00003112 Informative Direct
Biological Process (BP) negative regulation of developmental process 0.0000000009375 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.0000009562 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.00003215 Informative Direct
Biological Process (BP) regulation of nervous system development 0.0006312 Informative Direct
Biological Process (BP) cardiovascular system development 0.00005522 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0.001292 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 0.07729 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.002169 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.001193 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.01578 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.001583 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.007439 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.003144 Informative Inherited
Biological Process (BP) regulation of cell development 0.003063 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.004138 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.001279 Informative Inherited
Biological Process (BP) angiogenesis 0.0000000007496 Highly Informative Direct
Biological Process (BP) protein phosphorylation 0 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.000000004791 Highly Informative Direct
Biological Process (BP) regulation of striated muscle tissue development 0.0000000000007324 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0.000000002785 Highly Informative Direct
Biological Process (BP) regulation of proteolysis 0.0001948 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 0.0000000001442 Highly Informative Direct
Biological Process (BP) regulation of protein ubiquitination 0.0007838 Highly Informative Direct
Biological Process (BP) regulation of protein catabolic process 0.00008055 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic process 0.0000000374 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0.0001631 Highly Informative Direct
Biological Process (BP) regulation of striated muscle cell differentiation 0.0000000000001052 Highly Informative Direct
Biological Process (BP) maintenance of location 0.0000000004904 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.0005136 Highly Informative Direct
Biological Process (BP) negative regulation of protein modification process 0.01503 Highly Informative Inherited
Biological Process (BP) negative regulation of phosphorylation 0.009593 Highly Informative Inherited
Biological Process (BP) regulation of MAP kinase activity 0.001889 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.04326 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0 Informative Direct
Molecular Function (MF) protein kinase activity 0 Highly Informative Direct
Cellular Component (CC) membrane 0.05863 Least Informative Inherited
Cellular Component (CC) cell projection 0.0000000000005496 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.0334 Moderately Informative Inherited
Cellular Component (CC) cell junction 0 Informative Direct
Cellular Component (CC) cell leading edge 0.0000001198 Informative Direct
Cellular Component (CC) synapse part 0 Informative Direct
Cellular Component (CC) neuron projection 0.007364 Informative Inherited
Cellular Component (CC) adherens junction 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0InformativeDirect

Document: EC annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAngiogenesis0InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus0.00000009473Least InformativeDirect
Cellular componentCell membrane0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.000000001541Moderately InformativeDirect
Post-translational modificationTyrosine-protein kinase0Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR005189 SSF68993 Protein matches
Abstract

Focal adhesion kinase (FAK) is a tyrosine kinase found in focal adhesions, intracellular signaling complexes that are formed following engagement of the extracellular matrix by integrins. The C-terminal "focal adhesion targeting" (FAT) region is necessary and sufficient for localizing FAK to focal adhesions. The crystal structure of FAT shows it forms a four-helix bundle that resembles those found in two other proteins involved in cell adhesion, alpha-catenin and vinculin [PubMed11799401]. The binding of FAT to the focal adhesion protein, paxillin, requires the integrity of the helical bundle, whereas binding to another focal adhesion protein, talin, does not.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a FAT domain of focal adhesion kinase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the FAT domain of focal adhesion kinase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]