SUPERFAMILY 1.75 HMM library and genome assignments server

FAT domain of focal adhesion kinase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Four-helical up-and-down bundle [ 47161] (28)
Superfamily:   FAT domain of focal adhesion kinase [ 68993]
Families:   FAT domain of focal adhesion kinase [ 68994]


Superfamily statistics
Genomes (128) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 357 359 7
Proteins 356 358 7


Functional annotation
General category Regulation
Detailed category Kinases/phosphatases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.0000000000004909 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.0000002888 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.0000003085 Least Informative Direct
Biological Process (BP) localization 0.00004809 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.01928 Least Informative Inherited
Biological Process (BP) developmental process 0.03633 Least Informative Inherited
Biological Process (BP) positive regulation of biological process 0.455 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.1896 Least Informative Inherited
Biological Process (BP) response to stimulus 0.248 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.05333 Least Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0.00000000000001414 Moderately Informative Direct
Biological Process (BP) regulation of phosphorus metabolic process 0.00000000000001752 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.00000000000005029 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.000000000001165 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.000000003487 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.0000000209 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.000000124 Moderately Informative Direct
Biological Process (BP) single-organism organelle organization 0.000002423 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.00002319 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.00006253 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.0001609 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0.0003083 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0.5903 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.01392 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.04569 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.005562 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.008199 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.001878 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.3432 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.05954 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.1232 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0 Informative Direct
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) regulation of protein phosphorylation 0 Informative Direct
Biological Process (BP) regulation of transferase activity 0 Informative Direct
Biological Process (BP) cytoskeleton organization 0.000000000009112 Informative Direct
Biological Process (BP) regulation of growth 0.0000000001529 Informative Direct
Biological Process (BP) synaptic transmission 0.000000001574 Informative Direct
Biological Process (BP) negative regulation of developmental process 0.000000001821 Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.000000002482 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.000001335 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.000002624 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0.00001049 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.00003178 Informative Direct
Biological Process (BP) generation of neurons 0.00003192 Informative Direct
Biological Process (BP) regulation of locomotion 0.00003443 Informative Direct
Biological Process (BP) cardiovascular system development 0.00005705 Informative Direct
Biological Process (BP) positive regulation of catabolic process 0.00006117 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.0001045 Informative Direct
Biological Process (BP) negative regulation of catalytic activity 0.0002332 Informative Direct
Biological Process (BP) regulation of MAPK cascade 0.0004388 Informative Direct
Biological Process (BP) regulation of nervous system development 0.0007056 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0.001505 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 0.03692 Informative Inherited
Biological Process (BP) positive regulation of gene expression 0.008441 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.004285 Informative Inherited
Biological Process (BP) negative regulation of cellular protein metabolic process 0.00276 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.002813 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.01262 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.001545 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.00407 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.001273 Informative Inherited
Biological Process (BP) protein phosphorylation 0 Highly Informative Direct
Biological Process (BP) regulation of protein ubiquitination 0.00000000000159 Highly Informative Direct
Biological Process (BP) regulation of proteolysis involved in cellular protein catabolic process 0.00000000000195 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 0.0000000001436 Highly Informative Direct
Biological Process (BP) angiogenesis 0.000000001534 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0.000000002811 Highly Informative Direct
Biological Process (BP) maintenance of location 0.000000003703 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.000000004718 Highly Informative Direct
Biological Process (BP) positive regulation of protein modification by small protein conjugation or removal 0.000006535 Highly Informative Direct
Biological Process (BP) negative regulation of nervous system development 0.00001305 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0.0001676 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0.0002828 Highly Informative Direct
Biological Process (BP) negative regulation of protein phosphorylation 0.006697 Highly Informative Inherited
Biological Process (BP) regulation of protein serine/threonine kinase activity 0.4598 Highly Informative Inherited
Biological Process (BP) negative regulation of transferase activity 0.004386 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular signal transduction 0.00226 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.04515 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0 Informative Direct
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) protein kinase activity 0 Highly Informative Direct
Cellular Component (CC) membrane 0.01952 Least Informative Inherited
Cellular Component (CC) cell projection 0.0000000000007358 Moderately Informative Direct
Cellular Component (CC) plasma membrane part 0.0006933 Moderately Informative Direct
Cellular Component (CC) cell junction 0 Informative Direct
Cellular Component (CC) synapse 0.00000000000002302 Informative Direct
Cellular Component (CC) cell leading edge 0.0000001176 Informative Direct
Cellular Component (CC) neuron projection 0.005616 Informative Inherited
Cellular Component (CC) adherens junction 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0InformativeDirect

Document: EC annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAngiogenesis0InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus0.00000009473Least InformativeDirect
Cellular componentCell membrane0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.000000001541Moderately InformativeDirect
Post-translational modificationTyrosine-protein kinase0Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR005189 SSF68993 Protein matches
Abstract

Focal adhesion kinase (FAK) is a tyrosine kinase found in focal adhesions, intracellular signaling complexes that are formed following engagement of the extracellular matrix by integrins. The C-terminal "focal adhesion targeting" (FAT) region is necessary and sufficient for localizing FAK to focal adhesions. The crystal structure of FAT shows it forms a four-helix bundle that resembles those found in two other proteins involved in cell adhesion, alpha-catenin and vinculin [PubMed11799401]. The binding of FAT to the focal adhesion protein, paxillin, requires the integrity of the helical bundle, whereas binding to another focal adhesion protein, talin, does not.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a FAT domain of focal adhesion kinase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the FAT domain of focal adhesion kinase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]