SUPERFAMILY 1.75 HMM library and genome assignments server


FAT domain of focal adhesion kinase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Four-helical up-and-down bundle [ 47161] (28)
Superfamily:   FAT domain of focal adhesion kinase [ 68993]
Families:   FAT domain of focal adhesion kinase [ 68994]


Superfamily statistics
Genomes (117) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 339 312 7
Proteins 338 311 7


Functional annotation
General category Regulation
Detailed category Kinases/phosphatases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 8.741e-08 Least Informative Direct
Biological Process (BP) multicellular organismal process 5.029e-07 Least Informative Direct
Biological Process (BP) regulation of cellular process 8.481e-07 Least Informative Direct
Biological Process (BP) localization 4.09e-06 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.9491 Least Informative Inherited
Biological Process (BP) response to stimulus 0.1152 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.0696 Least Informative Inherited
Biological Process (BP) developmental process 0.03762 Least Informative Inherited
Biological Process (BP) regulation of developmental process 0 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 1.086e-14 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 1.461e-12 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 9.998e-07 Moderately Informative Direct
Biological Process (BP) regulation of programmed cell death 1.522e-06 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 4.392e-06 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 5.515e-06 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 6.886e-06 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 9.606e-06 Moderately Informative Direct
Biological Process (BP) cellular localization 1.225e-05 Moderately Informative Direct
Biological Process (BP) system process 3.693e-05 Moderately Informative Direct
Biological Process (BP) organelle organization 5.718e-05 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 6.21e-05 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0.000147 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.0002506 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.004714 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.01019 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.4645 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.01005 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.06408 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.0108 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.3565 Moderately Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0 Informative Direct
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0 Informative Direct
Biological Process (BP) cytoskeleton organization 1.046e-12 Informative Direct
Biological Process (BP) regulation of growth 1.272e-11 Informative Direct
Biological Process (BP) negative regulation of developmental process 8.586e-10 Informative Direct
Biological Process (BP) regulation of kinase activity 1.502e-08 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 2.38e-08 Informative Direct
Biological Process (BP) positive regulation of cell proliferation 4.19e-08 Informative Direct
Biological Process (BP) regulation of intracellular protein kinase cascade 9.427e-08 Informative Direct
Biological Process (BP) regulation of protein phosphorylation 9.523e-08 Informative Direct
Biological Process (BP) positive regulation of protein metabolic process 1.168e-07 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 1.583e-07 Informative Direct
Biological Process (BP) positive regulation of signal transduction 4.344e-07 Informative Direct
Biological Process (BP) transmission of nerve impulse 6.641e-07 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 8.43e-06 Informative Direct
Biological Process (BP) generation of neurons 1.022e-05 Informative Direct
Biological Process (BP) cardiovascular system development 1.055e-05 Informative Direct
Biological Process (BP) regulation of cellular component movement 1.175e-05 Informative Direct
Biological Process (BP) regulation of locomotion 1.239e-05 Informative Direct
Biological Process (BP) cell-cell signaling 1.542e-05 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 1.662e-05 Informative Direct
Biological Process (BP) regulation of nervous system development 0.0005775 Informative Direct
Biological Process (BP) negative regulation of cell death 0.007223 Informative Inherited
Biological Process (BP) regulation of cell development 0.002874 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.001176 Informative Inherited
Biological Process (BP) protein phosphorylation 0 Highly Informative Direct
Biological Process (BP) peptidyl-tyrosine modification 0 Highly Informative Direct
Biological Process (BP) regulation of protein ubiquitination 3.798e-13 Highly Informative Direct
Biological Process (BP) regulation of proteolysis 1.508e-12 Highly Informative Direct
Biological Process (BP) regulation of protein catabolic process 1.758e-12 Highly Informative Direct
Biological Process (BP) angiogenesis 2.989e-11 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 4.519e-11 Highly Informative Direct
Biological Process (BP) maintenance of location 4.501e-10 Highly Informative Direct
Biological Process (BP) positive regulation of protein kinase activity 6.134e-10 Highly Informative Direct
Biological Process (BP) negative regulation of growth 1.168e-09 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 1.794e-09 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 5.124e-07 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0.0001883 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.0005451 Highly Informative Direct
Molecular Function (MF) binding 0.0363 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0 Informative Direct
Molecular Function (MF) protein kinase activity 0 Highly Informative Direct
Cellular Component (CC) cell projection 5.56e-13 Moderately Informative Direct
Cellular Component (CC) synapse part 5.404e-14 Informative Direct
Cellular Component (CC) cell leading edge 1.439e-07 Informative Direct
Cellular Component (CC) neuron projection 0.1253 Informative Inherited
Cellular Component (CC) adherens junction 0 Highly Informative Direct
Cellular Component (CC) cell-substrate junction 0 Highly Informative Direct
Cellular Component (CC) axon part 1.246e-06 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0InformativeDirect

Document: EC annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAngiogenesis0InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus9.08e-08Least InformativeDirect
Cellular componentCell membrane0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationDevelopmental protein1.559e-09Moderately InformativeDirect
Post-translational modificationTyrosine-protein kinase0Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR005189 SSF68993 Protein matches
Abstract

Focal adhesion kinase (FAK) is a tyrosine kinase found in focal adhesions, intracellular signaling complexes that are formed following engagement of the extracellular matrix by integrins. The C-terminal "focal adhesion targeting" (FAT) region is necessary and sufficient for localizing FAK to focal adhesions. The crystal structure of FAT shows it forms a four-helix bundle that resembles those found in two other proteins involved in cell adhesion, alpha-catenin and vinculin [PubMed11799401]. The binding of FAT to the focal adhesion protein, paxillin, requires the integrity of the helical bundle, whereas binding to another focal adhesion protein, talin, does not.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a FAT domain of focal adhesion kinase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the FAT domain of focal adhesion kinase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]