SUPERFAMILY 1.75 HMM library and genome assignments server


PEP carboxykinase N-terminal domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   PEP carboxykinase N-terminal domain [ 68922]
Superfamily:   PEP carboxykinase N-terminal domain [ 68923]
Families:   PEP carboxykinase N-terminal domain [ 68924] (2)


Superfamily statistics
Genomes (2,150) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 2,733 6,151 7
Proteins 2,726 6,144 7


Functional annotation
General category Metabolism
Detailed category Energy

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biosynthetic process 5.229e-07 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.05189 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.7221 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 2.447e-14 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 1.466e-08 Moderately Informative Direct
Biological Process (BP) cellular lipid metabolic process 0.0005711 Moderately Informative Direct
Biological Process (BP) lipid biosynthetic process 0.05363 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.01397 Moderately Informative Inherited
Biological Process (BP) single-organism biosynthetic process 0.07067 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.002403 Moderately Informative Inherited
Biological Process (BP) hexose metabolic process 0 Informative Direct
Biological Process (BP) carbohydrate biosynthetic process 0 Informative Direct
Biological Process (BP) glycerolipid metabolic process 1.598e-07 Informative Direct
Biological Process (BP) cellular carbohydrate metabolic process 0.0006471 Informative Direct
Biological Process (BP) alcohol metabolic process 0.003984 Informative Inherited
Biological Process (BP) organic hydroxy compound biosynthetic process 0.001907 Informative Inherited
Biological Process (BP) monosaccharide biosynthetic process 0 Highly Informative Direct
Biological Process (BP) acylglycerol metabolic process 4.67e-11 Highly Informative Direct
Biological Process (BP) internal protein amino acid acetylation 1.29e-09 Highly Informative Direct
Biological Process (BP) alcohol biosynthetic process 1.737e-08 Highly Informative Direct
Biological Process (BP) polyol metabolic process 4.927e-08 Highly Informative Direct
Molecular Function (MF) lyase activity 0 Moderately Informative Direct
Molecular Function (MF) carbon-carbon lyase activity 0 Informative Direct
Molecular Function (MF) carboxy-lyase activity 0 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 5.01e-07 Least Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Carboxy-lyases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect

Document: WP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Carbon-carbon lyases0Moderately InformativeDirect
Enzyme Commission (EC)Carboxy-lyases0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processGluconeogenesis0Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionManganese0Moderately InformativeDirect
Molecular functionGTP-binding3.084e-08InformativeDirect
Post-translational modificationLyase0Moderately InformativeDirect
Post-translational modificationDecarboxylase0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)carbohydrate metabolism0Least InformativeDirect
UniPathway (UP)carbohydrate biosynthesis0Moderately InformativeDirect
UniPathway (UP)gluconeogenesis0InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR008210 SSF68923 Protein matches
Abstract

This entry represents the N-terminal domain found in both GTP-utilising and ATP-utilising phosphoenolpyruvate carboxykinase enzymes.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 4 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a PEP carboxykinase N-terminal domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 4 hidden Markov models representing the PEP carboxykinase N-terminal domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]