SUPERFAMILY 1.75 HMM library and genome assignments server


SAP domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   LEM/SAP HeH motif [ 63450] (6)
Superfamily:   SAP domain [ 68906]
Families:   SAP domain [ 68907] (7)


Superfamily statistics
Genomes (543) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 4,805 6,290 8
Proteins 4,684 6,200 7


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of metabolic process 0 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 7.054e-14 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 1.859e-05 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 2.75e-05 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.0005172 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.151 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.02346 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.01959 Least Informative Inherited
Biological Process (BP) response to stimulus 0.6051 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.6117 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.001212 Least Informative Inherited
Biological Process (BP) developmental process 0.378 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.3173 Least Informative Inherited
Biological Process (BP) cellular response to stress 3.772e-10 Moderately Informative Direct
Biological Process (BP) regulation of programmed cell death 1.177e-09 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 7.03e-08 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.000338 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.7983 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.5973 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.002168 Moderately Informative Inherited
Biological Process (BP) tissue development 0.3763 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.7573 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.082 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.015 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.1115 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.002851 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.3789 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.009293 Moderately Informative Inherited
Biological Process (BP) immune system process 0.03202 Moderately Informative Inherited
Biological Process (BP) organ development 0.00265 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.1929 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.8707 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 0.9881 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.9835 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.005149 Moderately Informative Inherited
Biological Process (BP) gene expression 0.7672 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) protein modification by small protein conjugation or removal 0 Informative Direct
Biological Process (BP) regulation of peptidase activity 4.892e-11 Informative Direct
Biological Process (BP) regulation of apoptotic signaling pathway 1.874e-09 Informative Direct
Biological Process (BP) negative regulation of signaling 4.565e-09 Informative Direct
Biological Process (BP) negative regulation of catalytic activity 1.092e-08 Informative Direct
Biological Process (BP) negative regulation of cell communication 3.076e-08 Informative Direct
Biological Process (BP) chromosome organization 6.672e-08 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 1.745e-07 Informative Direct
Biological Process (BP) DNA metabolic process 7.187e-07 Informative Direct
Biological Process (BP) response to DNA damage stimulus 5.231e-06 Informative Direct
Biological Process (BP) positive regulation of gene expression 1.812e-05 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 7.276e-05 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 8.43e-05 Informative Direct
Biological Process (BP) hematopoietic or lymphoid organ development 0.0001377 Informative Direct
Biological Process (BP) muscle tissue development 0.000295 Informative Direct
Biological Process (BP) growth 0.0008809 Informative Direct
Biological Process (BP) apoptotic process 0.08103 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0.04444 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.002772 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.08783 Informative Inherited
Biological Process (BP) muscle structure development 0.002753 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.07591 Informative Inherited
Biological Process (BP) sensory organ development 0.01019 Informative Inherited
Biological Process (BP) cardiovascular system development 0.1367 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.9467 Informative Inherited
Biological Process (BP) regulation of immune response 0.07915 Informative Inherited
Biological Process (BP) regulation of defense response 0.4234 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.02461 Informative Inherited
Biological Process (BP) response to other organism 0.008265 Informative Inherited
Biological Process (BP) defense response 0.3836 Informative Inherited
Biological Process (BP) positive regulation of protein modification process 0.7251 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.006921 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.3567 Informative Inherited
Biological Process (BP) cell cycle process 0.07602 Informative Inherited
Biological Process (BP) protein catabolic process 0.05178 Informative Inherited
Biological Process (BP) proteolysis 0.2858 Informative Inherited
Biological Process (BP) RNA processing 0.3769 Informative Inherited
Biological Process (BP) negative regulation of endopeptidase activity 3.77e-15 Highly Informative Direct
Biological Process (BP) regulation of innate immune response 4.232e-09 Highly Informative Direct
Biological Process (BP) negative regulation of mitotic cell cycle phase transition 7.831e-08 Highly Informative Direct
Biological Process (BP) regulation of protein catabolic process 1.776e-07 Highly Informative Direct
Biological Process (BP) cardiac muscle tissue development 2.104e-07 Highly Informative Direct
Biological Process (BP) regulation of cysteine-type endopeptidase activity involved in apoptotic process 1.37e-06 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic signaling pathway 1.856e-06 Highly Informative Direct
Biological Process (BP) positive regulation of defense response 1.87e-06 Highly Informative Direct
Biological Process (BP) defense response to bacterium 2.262e-06 Highly Informative Direct
Biological Process (BP) developmental growth 5.467e-06 Highly Informative Direct
Biological Process (BP) regulation of striated muscle tissue development 1.548e-05 Highly Informative Direct
Biological Process (BP) proteasomal protein catabolic process 1.767e-05 Highly Informative Direct
Biological Process (BP) response to ionizing radiation 5.396e-05 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-dependent 0.0001502 Highly Informative Direct
Biological Process (BP) ubiquitin-dependent protein catabolic process 0.0002924 Highly Informative Direct
Biological Process (BP) double-strand break repair 0.0004053 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.01671 Highly Informative Inherited
Biological Process (BP) DNA damage checkpoint 0.009484 Highly Informative Inherited
Biological Process (BP) mRNA processing 0.02868 Highly Informative Inherited
Biological Process (BP) RNA splicing 0.03974 Highly Informative Inherited
Molecular Function (MF) binding 1.87e-09 Least Informative Direct
Molecular Function (MF) nucleic acid binding 8.874e-06 Moderately Informative Direct
Molecular Function (MF) anion binding 0.3439 Moderately Informative Inherited
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 0 Informative Direct
Molecular Function (MF) lipid binding 0.1595 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.007584 Informative Inherited
Molecular Function (MF) DNA binding 0.01179 Informative Inherited
Molecular Function (MF) small conjugating protein ligase activity 0 Highly Informative Direct
Molecular Function (MF) protein binding transcription factor activity 1.335e-14 Highly Informative Direct
Molecular Function (MF) actin binding 5.463e-08 Highly Informative Direct
Molecular Function (MF) phosphatidylinositol binding 0.0001574 Highly Informative Direct
Molecular Function (MF) structure-specific DNA binding 0.1085 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.0004545 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.1913 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1.294e-11 Moderately Informative Direct
Cellular Component (CC) nuclear part 5.605e-08 Moderately Informative Direct
Cellular Component (CC) chromosome 0.02753 Informative Inherited
Cellular Component (CC) nucleoplasm part 1 Informative Inherited
Cellular Component (CC) nuclear body 4.317e-07 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides2.257e-11Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an4.713e-16Moderately InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.3049Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.7166Least InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.08604Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.2692Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.3196Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron physiology0.03563InformativeInherited
Mammalian Phenotype (MP)increased apoptosis0.3193InformativeInherited
Mammalian Phenotype (MP)abnormal basal ganglion morphology0.0002802Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)metabolism and growth0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect
Fly Phenotype (FP)lethal - all die before end of P-stage0Moderately InformativeDirect
Fly Phenotype (FP)lethal - all die before end of larval stage0InformativeDirect
Fly Phenotype (FP)some die during larval stage0Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)cell0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases3.519e-06Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides1.277e-12Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0.003086Moderately InformativeInherited
Enzyme Commission (EC)DNA helicase0InformativeDirect
Enzyme Commission (EC)Pentosyltransferases0.0003631InformativeDirect
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase2.586e-11Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0Moderately InformativeDirect
Biological processApoptosis4.713e-16Moderately InformativeDirect
Biological processDNA damage2.612e-06Moderately InformativeDirect
Biological processUbl conjugation pathway0InformativeDirect
Biological processDNA recombination6.78e-10InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentSecreted0.0002847Moderately InformativeDirect
Cellular componentChromosome5.064e-11InformativeDirect
Cellular componentTelomere8.058e-06Highly InformativeDirect
DomainZinc-finger3.653e-07Moderately InformativeDirect
DomainCoiled coil2.958e-05Moderately InformativeDirect
Molecular functionZinc4.053e-06Least InformativeDirect
Molecular functionDNA-binding9.24e-16Moderately InformativeDirect
Post-translational modificationHydrolase0.3266Least InformativeInherited
Post-translational modificationActivator7.334e-11Moderately InformativeDirect
Post-translational modificationDevelopmental protein1.188e-09Moderately InformativeDirect
Post-translational modificationRepressor2.358e-09Moderately InformativeDirect
Post-translational modificationLigase7.308e-07Moderately InformativeDirect
Post-translational modificationHelicase2.12e-11InformativeDirect
Post-translational modificationGrowth factor1.199e-09InformativeDirect
Post-translational modificationPhosphoprotein2.777e-08Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond2.555e-07Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein sumoylation0Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 7 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a SAP domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 7 hidden Markov models representing the SAP domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]