SUPERFAMILY 1.75 HMM library and genome assignments server


SAP domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   LEM/SAP HeH motif [ 63450] (6)
Superfamily:   SAP domain [ 68906]
Families:   SAP domain [ 68907] (7)


Superfamily statistics
Genomes (478) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 4,304 3,823 8
Proteins 4,197 3,750 7


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of metabolic process 8.502e-14 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 6.76e-11 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 2.494e-07 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 6.165e-07 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 3.739e-05 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.0001683 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.02036 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.05662 Least Informative Inherited
Biological Process (BP) response to stimulus 0.5141 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.1903 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) developmental process 0.1142 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.1091 Least Informative Inherited
Biological Process (BP) cellular response to stress 6.546e-09 Moderately Informative Direct
Biological Process (BP) regulation of cellular metabolic process 3.698e-06 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0.0004406 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.0006522 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.5071 Moderately Informative Inherited
Biological Process (BP) tissue development 0.3022 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.1654 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.002045 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.003799 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 0.05523 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.09946 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.002485 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.126 Moderately Informative Inherited
Biological Process (BP) immune system process 0.01423 Moderately Informative Inherited
Biological Process (BP) organ development 0.001202 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.2522 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.4754 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.5444 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.6018 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 0.6063 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.4608 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.001518 Moderately Informative Inherited
Biological Process (BP) gene expression 0.2369 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.5301 Moderately Informative Inherited
Biological Process (BP) protein modification by small protein conjugation or removal 4.008e-15 Informative Direct
Biological Process (BP) chromosome organization 8.238e-08 Informative Direct
Biological Process (BP) DNA metabolic process 1.802e-06 Informative Direct
Biological Process (BP) positive regulation of gene expression 8.465e-06 Informative Direct
Biological Process (BP) hematopoietic or lymphoid organ development 5.368e-05 Informative Direct
Biological Process (BP) response to DNA damage stimulus 0.0001297 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.0001399 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0.0001601 Informative Direct
Biological Process (BP) muscle tissue development 0.0004013 Informative Direct
Biological Process (BP) growth 0.0008396 Informative Direct
Biological Process (BP) anatomical structure homeostasis 0.0008488 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.002878 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.00846 Informative Inherited
Biological Process (BP) muscle structure development 0.003088 Informative Inherited
Biological Process (BP) sensory organ development 0.01225 Informative Inherited
Biological Process (BP) cardiovascular system development 0.1291 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.06527 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.001208 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.002761 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.00613 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.02365 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 1 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.009684 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.0136 Informative Inherited
Biological Process (BP) cell cycle process 0.02015 Informative Inherited
Biological Process (BP) DNA packaging 2.642e-13 Highly Informative Direct
Biological Process (BP) mitotic cell cycle checkpoint 3.349e-09 Highly Informative Direct
Biological Process (BP) cardiac muscle tissue development 1.261e-07 Highly Informative Direct
Biological Process (BP) regulation of protein catabolic process 1.269e-07 Highly Informative Direct
Biological Process (BP) developmental growth 3.287e-06 Highly Informative Direct
Biological Process (BP) response to ionizing radiation 4.851e-05 Highly Informative Direct
Biological Process (BP) RNA splicing, via transesterification reactions 0.0002908 Highly Informative Direct
Biological Process (BP) negative regulation of signal transduction 0.0004621 Highly Informative Direct
Biological Process (BP) positive regulation of cell differentiation 0.004848 Highly Informative Inherited
Biological Process (BP) DNA damage checkpoint 0.003461 Highly Informative Inherited
Biological Process (BP) DNA repair 0.2043 Highly Informative Inherited
Biological Process (BP) mRNA processing 0.02895 Highly Informative Inherited
Molecular Function (MF) binding 1.853e-08 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) heterocyclic compound binding 5.281e-05 Moderately Informative Direct
Molecular Function (MF) organic cyclic compound binding 8.171e-05 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.4017 Moderately Informative Inherited
Molecular Function (MF) protein binding 0.1277 Moderately Informative Inherited
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 6.774e-14 Informative Direct
Molecular Function (MF) nuclease activity 0.0009118 Informative Direct
Molecular Function (MF) DNA binding 0.05274 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.01176 Informative Inherited
Molecular Function (MF) small conjugating protein ligase activity 0 Highly Informative Direct
Molecular Function (MF) transcription factor binding transcription factor activity 1.562e-15 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.0001757 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.08588 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 4.861e-12 Moderately Informative Direct
Cellular Component (CC) nuclear part 1.39e-08 Moderately Informative Direct
Cellular Component (CC) chromosome 0.02789 Informative Inherited
Cellular Component (CC) nucleoplasm part 1 Informative Inherited
Cellular Component (CC) nuclear body 0.0002478 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides2.257e-11Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an4.713e-16Moderately InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.4063Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.7434Least InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.08572Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.2745Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.3781Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron physiology0.03878InformativeInherited
Mammalian Phenotype (MP)increased apoptosis0.3157InformativeInherited
Mammalian Phenotype (MP)abnormal basal ganglion morphology0.0003118Highly InformativeDirect
Mammalian Phenotype (MP)abnormal neuron apoptosis0.008244Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)lethal0Least InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)cell0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases4.087e-06Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides1.518e-12Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0.003454Moderately InformativeInherited
Enzyme Commission (EC)DNA helicase0InformativeDirect
Enzyme Commission (EC)Pentosyltransferases0.0004301InformativeDirect
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase2.664e-11Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0Moderately InformativeDirect
Biological processApoptosis2.329e-16Moderately InformativeDirect
Biological processDNA damage2.973e-06Moderately InformativeDirect
Biological processUbl conjugation pathway0InformativeDirect
Biological processDNA recombination5.173e-10InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentSecreted0.0002995Moderately InformativeDirect
Cellular componentChromosome4.41e-11InformativeDirect
Cellular componentTelomere6.018e-06Highly InformativeDirect
DomainCoiled coil2.226e-06Moderately InformativeDirect
Molecular functionZinc3.244e-06Least InformativeDirect
Molecular functionMetal-binding0.2079Least InformativeInherited
Molecular functionNucleotide-binding1Least InformativeInherited
Molecular functionDNA-binding4.612e-16Moderately InformativeDirect
Molecular functionZinc-finger5.461e-15Moderately InformativeDirect
Molecular functionHelicase2.048e-11InformativeDirect
Post-translational modificationActivator6.302e-11Moderately InformativeDirect
Post-translational modificationDevelopmental protein9.563e-10Moderately InformativeDirect
Post-translational modificationRepressor1.995e-09Moderately InformativeDirect
Post-translational modificationLigase7.146e-07Moderately InformativeDirect
Post-translational modificationGrowth factor1.206e-09InformativeDirect
Post-translational modificationPhosphoprotein1.675e-09Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond1.711e-07Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein sumoylation0Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 7 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a SAP domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 7 hidden Markov models representing the SAP domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]