SUPERFAMILY 1.75 HMM library and genome assignments server


SAP domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   LEM/SAP HeH motif [ 63450] (6)
Superfamily:   SAP domain [ 68906]
Families:   SAP domain [ 68907] (7)


Superfamily statistics
Genomes (492) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 4,368 3,823 8
Proteins 4,261 3,750 7


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of metabolic process 0 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 6.044e-14 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 7.372e-06 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 1.105e-05 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.0002611 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.000424 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.06213 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.02785 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.01979 Least Informative Inherited
Biological Process (BP) response to stimulus 0.5482 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.6911 Least Informative Inherited
Biological Process (BP) developmental process 0.3309 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.2611 Least Informative Inherited
Biological Process (BP) cellular response to stress 4.188e-11 Moderately Informative Direct
Biological Process (BP) regulation of programmed cell death 4.473e-09 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 3.171e-08 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.0003049 Moderately Informative Direct
Biological Process (BP) organ development 0.0007798 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.7247 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.9247 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.004262 Moderately Informative Inherited
Biological Process (BP) tissue development 0.3601 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.1793 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.7637 Moderately Informative Inherited
Biological Process (BP) macromolecule catabolic process 0.1663 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.07062 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.0126 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.1294 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.00426 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.3148 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.003471 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.7913 Moderately Informative Inherited
Biological Process (BP) immune system process 0.01826 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.1499 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.8438 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.2062 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.5431 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.9972 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.003951 Moderately Informative Inherited
Biological Process (BP) gene expression 0.6272 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.9562 Moderately Informative Inherited
Biological Process (BP) regulation of peptidase activity 1.74e-11 Informative Direct
Biological Process (BP) regulation of apoptotic signaling pathway 8.848e-10 Informative Direct
Biological Process (BP) negative regulation of signaling 9.132e-10 Informative Direct
Biological Process (BP) negative regulation of cell communication 6.272e-09 Informative Direct
Biological Process (BP) negative regulation of catalytic activity 9.966e-09 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 4.548e-08 Informative Direct
Biological Process (BP) chromosome organization 6.928e-08 Informative Direct
Biological Process (BP) cell death 9.909e-08 Informative Direct
Biological Process (BP) DNA metabolic process 9.163e-07 Informative Direct
Biological Process (BP) response to DNA damage stimulus 6.074e-06 Informative Direct
Biological Process (BP) positive regulation of gene expression 2.523e-05 Informative Direct
Biological Process (BP) hematopoietic or lymphoid organ development 6.749e-05 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.0001001 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0.0001148 Informative Direct
Biological Process (BP) muscle tissue development 0.0002842 Informative Direct
Biological Process (BP) growth 0.0005675 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0.04826 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.003625 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.0816 Informative Inherited
Biological Process (BP) muscle structure development 0.002411 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.07627 Informative Inherited
Biological Process (BP) sensory organ development 0.009887 Informative Inherited
Biological Process (BP) cardiovascular system development 0.1493 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.9422 Informative Inherited
Biological Process (BP) regulation of immune response 0.08996 Informative Inherited
Biological Process (BP) regulation of defense response 0.4509 Informative Inherited
Biological Process (BP) response to bacterium 0.003314 Informative Inherited
Biological Process (BP) defense response 0.3666 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 1 Informative Inherited
Biological Process (BP) regulation of cell cycle 0.05043 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.3151 Informative Inherited
Biological Process (BP) cell cycle process 0.0848 Informative Inherited
Biological Process (BP) protein catabolic process 0.04477 Informative Inherited
Biological Process (BP) proteolysis 0.2514 Informative Inherited
Biological Process (BP) RNA processing 0.4648 Informative Inherited
Biological Process (BP) negative regulation of endopeptidase activity 0 Highly Informative Direct
Biological Process (BP) regulation of cysteine-type endopeptidase activity 7.325e-14 Highly Informative Direct
Biological Process (BP) regulation of innate immune response 1.691e-09 Highly Informative Direct
Biological Process (BP) negative regulation of mitotic cell cycle phase transition 2.817e-08 Highly Informative Direct
Biological Process (BP) regulation of protein catabolic process 8.229e-08 Highly Informative Direct
Biological Process (BP) cardiac muscle tissue development 1.112e-07 Highly Informative Direct
Biological Process (BP) cell cycle checkpoint 1.341e-07 Highly Informative Direct
Biological Process (BP) defense response to bacterium 2.272e-06 Highly Informative Direct
Biological Process (BP) positive regulation of defense response 2.473e-06 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic signaling pathway 2.543e-06 Highly Informative Direct
Biological Process (BP) developmental growth 3.773e-06 Highly Informative Direct
Biological Process (BP) proteasomal protein catabolic process 9.729e-06 Highly Informative Direct
Biological Process (BP) response to ionizing radiation 4.968e-05 Highly Informative Direct
Biological Process (BP) ubiquitin-dependent protein catabolic process 0.0001565 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-dependent 0.0001885 Highly Informative Direct
Biological Process (BP) double-strand break repair 0.0004089 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.01301 Highly Informative Inherited
Biological Process (BP) positive regulation of cell differentiation 0.0147 Highly Informative Inherited
Biological Process (BP) mRNA processing 0.02984 Highly Informative Inherited
Biological Process (BP) RNA splicing 0.03849 Highly Informative Inherited
Molecular Function (MF) binding 2.848e-12 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) nucleic acid binding 8.392e-06 Moderately Informative Direct
Molecular Function (MF) anion binding 0.3172 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.3862 Moderately Informative Inherited
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 0 Informative Direct
Molecular Function (MF) nuclease activity 0.0008516 Informative Direct
Molecular Function (MF) lipid binding 0.1666 Informative Inherited
Molecular Function (MF) DNA binding 0.009633 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.01655 Informative Inherited
Molecular Function (MF) small conjugating protein ligase activity 0 Highly Informative Direct
Molecular Function (MF) transcription factor binding transcription factor activity 1.555e-15 Highly Informative Direct
Molecular Function (MF) phosphatidylinositol binding 9.863e-05 Highly Informative Direct
Molecular Function (MF) transcription regulatory region DNA binding 0.0001827 Highly Informative Direct
Molecular Function (MF) structure-specific DNA binding 0.1123 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.004464 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.6899 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 2.278e-09 Moderately Informative Direct
Cellular Component (CC) nuclear part 1.042e-06 Moderately Informative Direct
Cellular Component (CC) chromosome 0.0008361 Informative Direct
Cellular Component (CC) nucleoplasm part 1 Informative Inherited
Cellular Component (CC) nuclear periphery 4.3e-12 Highly Informative Direct
Cellular Component (CC) nuclear body 3.75e-07 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides2.257e-11Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an4.713e-16Moderately InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.2768Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.7135Least InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.0877Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.2635Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.3646Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron physiology0.03392InformativeInherited
Mammalian Phenotype (MP)increased apoptosis0.3222InformativeInherited
Mammalian Phenotype (MP)abnormal basal ganglion morphology0.0002934Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect
Fly Phenotype (FP)lethal - all die before end of P-stage0Moderately InformativeDirect
Fly Phenotype (FP)lethal - all die before end of first instar larval stage0InformativeDirect
Fly Phenotype (FP)some die during larval stage0InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)cell0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases3.851e-06Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides1.37e-12Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0.003154Moderately InformativeInherited
Enzyme Commission (EC)DNA helicase0InformativeDirect
Enzyme Commission (EC)Pentosyltransferases0.0003692InformativeDirect
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase2.722e-11Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0Moderately InformativeDirect
Biological processApoptosis4.701e-16Moderately InformativeDirect
Biological processDNA damage2.755e-06Moderately InformativeDirect
Biological processUbl conjugation pathway0InformativeDirect
Biological processDNA recombination6.932e-10InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentSecreted0.0002628Moderately InformativeDirect
Cellular componentChromosome4.731e-11InformativeDirect
Cellular componentTelomere5.62e-06Highly InformativeDirect
DomainZinc-finger3.598e-07Moderately InformativeDirect
DomainCoiled coil2.807e-05Moderately InformativeDirect
Molecular functionDNA-binding4.618e-16Least InformativeDirect
Molecular functionZinc3.844e-06Least InformativeDirect
Post-translational modificationHydrolase0.3251Least InformativeInherited
Post-translational modificationActivator7.295e-11Moderately InformativeDirect
Post-translational modificationDevelopmental protein1.217e-09Moderately InformativeDirect
Post-translational modificationRepressor2.132e-09Moderately InformativeDirect
Post-translational modificationLigase7.758e-07Moderately InformativeDirect
Post-translational modificationHelicase2.021e-11InformativeDirect
Post-translational modificationGrowth factor1.131e-09InformativeDirect
Post-translational modificationPhosphoprotein2.857e-08Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond2.056e-07Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 7 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a SAP domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 7 hidden Markov models representing the SAP domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]