SUPERFAMILY 1.75 HMM library and genome assignments server


Cellulose docking domain, dockering superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Cellulose docking domain, dockering [ 64570]
Superfamily:   Cellulose docking domain, dockering [ 64571]
Families:   Cellulose docking domain, dockering [ 64572]


Superfamily statistics
Genomes (0) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 0 180 1
Proteins 0 90 1


Functional annotation
General category Metabolism
Detailed category Polysaccharide metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl5.162e-13Moderately InformativeDirect

Document: EC annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Glycosylases2.115e-08Moderately InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
DomainRepeat0Least InformativeDirect
DomainSignal0Least InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationGlycosidase2.19e-09InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)glycan metabolism0Moderately InformativeDirect
UniPathway (UP)glycan degradation0InformativeDirect
UniPathway (UP)xylan degradation0Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR009034 SSF64571 Protein matches
Abstract

In anaerobic microorganisms, the degradation of plant cell walls in order to recycle the photosynthetically fixed carbon is carried out by a multifunctional complex termed the cellulosome. The cellulosome consists of a number of independent enzyme components, each of which contains a conserved dockerin domain. The dockerin domain functions to bind the enzyme to a cohesin domain within the protein scaffoldin protein, a multidomain protein containing a cellulose binding module for attachment to the host microorganism. The dockerin-cohesin binding enables the assembly of multiple polysaccharide-degrading enzymes to be brought together into the cellulosome complex. The dockerin sequences of bacterial and fungal enzymes are completely different. Fungal enzymes contain one, two or three copies of the dockerin sequence in tandem within the catalytic polypeptide, while in bacteria such as Clostridium thermocellum, the cellulosome catalytic components contain a single dockerin domain. The tandem dockerin domains, seen in the majority of anaerobic fungal plant cell wall degrading enzymes, could present multiple simultaneous binding sites and, therefore, permit tailoring of binding to catalytic demands. Furthermore, fungal dockerin domains have broad interspecies specificity, while bacterial dockerin domains appear species-specific. The structure of the N-terminal dockerin domain of Cel45A from the anaerobic fungus Piromyces equi displays an alpha/beta fold that is disulphide-rich [PubMed11524680].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cellulose docking domain, dockering domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Cellulose docking domain, dockering superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]