SUPERFAMILY 1.75 HMM library and genome assignments server

Satiety factor CART (cocaine and amphetamine regulated transcript) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Knottins (small inhibitors, toxins, lectins) [ 57015] (19)
Superfamily:   Satiety factor CART (cocaine and amphetamine regulated transcript) [ 64546]
Families:   Satiety factor CART (cocaine and amphetamine regulated transcript) [ 64547]


Superfamily statistics
Genomes (55) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 88 114 1
Proteins 88 114 1


Functional annotation
General category Regulation
Detailed category Receptor activity

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0.00007782 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0001432 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.616 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.006701 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.3398 Least Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0 Moderately Informative Direct
Biological Process (BP) signal transduction 0.000000007057 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 0.00000006356 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0.0000001393 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.0000002224 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0.0000002619 Moderately Informative Direct
Biological Process (BP) system process 0.0000003586 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.000001726 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0.000003763 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0.00003786 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.0007441 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.04429 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.01289 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.004589 Moderately Informative Inherited
Biological Process (BP) blood circulation 0.000000000006737 Informative Direct
Biological Process (BP) regulation of secretion 0.0000000002686 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0.0000000003054 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0.0000000003813 Informative Direct
Biological Process (BP) positive regulation of transport 0.0000000005854 Informative Direct
Biological Process (BP) regulation of kinase activity 0.0000000008666 Informative Direct
Biological Process (BP) response to nutrient levels 0.000000001355 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 0.000000001446 Informative Direct
Biological Process (BP) single-organism behavior 0.000000001681 Informative Direct
Biological Process (BP) regulation of protein phosphorylation 0.000000005002 Informative Direct
Biological Process (BP) regulation of intracellular protein kinase cascade 0.000000005407 Informative Direct
Biological Process (BP) positive regulation of protein metabolic process 0.000000006286 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.00000002709 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.00006913 Informative Direct
Biological Process (BP) regulation of system process 0.005135 Informative Inherited
Biological Process (BP) regulation of amine transport 0 Highly Informative Direct
Biological Process (BP) G-protein coupled receptor signaling pathway 0.000000000000003755 Highly Informative Direct
Biological Process (BP) negative regulation of response to external stimulus 0.0000000000001674 Highly Informative Direct
Biological Process (BP) regulation of blood pressure 0.0000000000001674 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 0.0000000000005703 Highly Informative Direct
Biological Process (BP) adult behavior 0.000000000002658 Highly Informative Direct
Biological Process (BP) circadian rhythm 0.000000000002856 Highly Informative Direct
Biological Process (BP) cellular response to starvation 0.00000000002985 Highly Informative Direct
Biological Process (BP) positive regulation of protein kinase activity 0.00000000005117 Highly Informative Direct
Biological Process (BP) regulation of response to nutrient levels 1 Highly Informative Inherited
Cellular Component (CC) extracellular region part 0.0000002799 Moderately Informative Direct
Cellular Component (CC) extracellular space 0.00000000573 Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentSecreted0Moderately InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues0Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR009106 SSF64546 Protein matches
Abstract

The cocaine and amphetamine regulated transcript (CART) is a brain-localised peptide that acts as a satiety factor in appetite regulation. CART was found to inhibit both normal and starvation-induced feeding, and completely blocks the feeding response induced by neuropeptide Y. CART is regulated by leptin in the hypothalamus, and can be transcriptionally induced after cocaine or amphetamine administration [PubMed9590691]. Posttranslational processing of CART produces an N-terminal CART peptide and a C-terminal CART peptide. The C-terminal CART peptide has been isolated from the hypothalamus, nucleus accumbens, and the anterior pituitary lobe in rats. C-terminal CART is the biologically active part of the molecule affecting food intake. The structure of C-terminal CART consists of a disulphide-bound fold containing a beta-hairpin and two adjacent disulphide bridges [PubMed11478874].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Satiety factor CART (cocaine and amphetamine regulated transcript) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Satiety factor CART (cocaine and amphetamine regulated transcript) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]