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Satiety factor CART (cocaine and amphetamine regulated transcript) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Knottins (small inhibitors, toxins, lectins) [ 57015] (19)
Superfamily:   Satiety factor CART (cocaine and amphetamine regulated transcript) [ 64546]
Families:   Satiety factor CART (cocaine and amphetamine regulated transcript) [ 64547]

 Superfamily statistics
Genomes (49) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 76 90 1
Proteins 76 90 1

 Functional annotation
General category Regulation
Detailed category Receptor activity

Document: Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 9.708e-05 Least Informative Direct
Biological Process (BP) response to stimulus 0.0001093 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.000274 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.0007563 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.6227 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.00861 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.3172 Least Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0 Moderately Informative Direct
Biological Process (BP) signal transduction 1.466e-08 Moderately Informative Direct
Biological Process (BP) homeostatic process 2.09e-07 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 2.908e-07 Moderately Informative Direct
Biological Process (BP) system process 5.626e-07 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 4.812e-06 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 6.759e-06 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 8.424e-06 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 6.199e-05 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.0003897 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0.0006421 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.03663 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.01316 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.00419 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.003396 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.002008 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 0.1122 Moderately Informative Inherited
Biological Process (BP) blood circulation 1.186e-11 Informative Direct
Biological Process (BP) regulation of secretion 2.291e-10 Informative Direct
Biological Process (BP) regulation of response to external stimulus 2.465e-10 Informative Direct
Biological Process (BP) positive regulation of transport 4.882e-10 Informative Direct
Biological Process (BP) regulation of kinase activity 1.219e-09 Informative Direct
Biological Process (BP) positive regulation of phosphorus metabolic process 1.723e-09 Informative Direct
Biological Process (BP) single-organism behavior 1.852e-09 Informative Direct
Biological Process (BP) regulation of protein phosphorylation 5.782e-09 Informative Direct
Biological Process (BP) regulation of intracellular protein kinase cascade 6.844e-09 Informative Direct
Biological Process (BP) positive regulation of protein metabolic process 8.061e-09 Informative Direct
Biological Process (BP) positive regulation of catalytic activity 1.502e-08 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 1.797e-08 Informative Direct
Biological Process (BP) protein phosphorylation 3.236e-08 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 8.636e-05 Informative Direct
Biological Process (BP) response to external stimulus 0.0005807 Informative Direct
Biological Process (BP) regulation of system process 0.004807 Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 5.966e-15 Highly Informative Direct
Biological Process (BP) feeding behavior 6.802e-14 Highly Informative Direct
Biological Process (BP) negative regulation of response to external stimulus 2.244e-13 Highly Informative Direct
Biological Process (BP) regulation of blood pressure 3.32e-13 Highly Informative Direct
Biological Process (BP) positive regulation of secretion 3.432e-12 Highly Informative Direct
Biological Process (BP) activation of protein kinase activity 4.836e-12 Highly Informative Direct
Biological Process (BP) adult behavior 5.895e-12 Highly Informative Direct
Biological Process (BP) regulation of neurological system process 1.796e-11 Highly Informative Direct
Biological Process (BP) cellular response to starvation 3.181e-11 Highly Informative Direct
Biological Process (BP) regulation of response to nutrient levels 1 Highly Informative Inherited
Cellular Component (CC) extracellular region 5.399e-07 Moderately Informative Direct
Cellular Component (CC) extracellular space 5.475e-09 Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentSecreted0Moderately InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues0Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR009106 SSF64546 Protein matches
Abstract

The cocaine and amphetamine regulated transcript (CART) is a brain-localised peptide that acts as a satiety factor in appetite regulation. CART was found to inhibit both normal and starvation-induced feeding, and completely blocks the feeding response induced by neuropeptide Y. CART is regulated by leptin in the hypothalamus, and can be transcriptionally induced after cocaine or amphetamine administration [PubMed9590691]. Posttranslational processing of CART produces an N-terminal CART peptide and a C-terminal CART peptide. The C-terminal CART peptide has been isolated from the hypothalamus, nucleus accumbens, and the anterior pituitary lobe in rats. C-terminal CART is the biologically active part of the molecule affecting food intake. The structure of C-terminal CART consists of a disulphide-bound fold containing a beta-hairpin and two adjacent disulphide bridges [PubMed11478874].


InterPro database

PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Satiety factor CART (cocaine and amphetamine regulated transcript) domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Satiety factor CART (cocaine and amphetamine regulated transcript) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]
Please cite: Gough, J., Karplus, K., Hughey, R. and Chothia, C. (2001). "Assignment of Homology to Genome Sequences using a Library of Hidden Markov Models that Represent all Proteins of Known Structure." J. Mol. Biol., 313(4), 903-919.

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© Copyright 2013 The SUPERFAMILY authors and Julian Gough.