SUPERFAMILY 1.75 HMM library and genome assignments server

Satiety factor CART (cocaine and amphetamine regulated transcript) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Knottins (small inhibitors, toxins, lectins) [ 57015] (19)
Superfamily:   Satiety factor CART (cocaine and amphetamine regulated transcript) [ 64546]
Families:   Satiety factor CART (cocaine and amphetamine regulated transcript) [ 64547]


Superfamily statistics
Genomes (55) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 88 114 1
Proteins 88 114 1


Functional annotation
General category Regulation
Detailed category Receptor activity

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0.00007782 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0003615 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.3732 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.6449 Least Informative Inherited
Biological Process (BP) positive regulation of biological process 0.1816 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.005467 Least Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0 Moderately Informative Direct
Biological Process (BP) signal transduction 0.000000007382 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 0.00000006886 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0.0000002694 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 0.0000002916 Moderately Informative Direct
Biological Process (BP) regulation of phosphorus metabolic process 0.0000002974 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.0000004783 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.000001795 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0.00001174 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0.00005294 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.0008103 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.01215 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.05921 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.007201 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.00478 Moderately Informative Inherited
Biological Process (BP) blood circulation 0.00000000000673 Informative Direct
Biological Process (BP) cellular response to external stimulus 0.0000000001759 Informative Direct
Biological Process (BP) regulation of secretion 0.0000000002957 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0.0000000003277 Informative Direct
Biological Process (BP) regulation of MAPK cascade 0.0000000007428 Informative Direct
Biological Process (BP) positive regulation of transport 0.0000000007667 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0.000000001012 Informative Direct
Biological Process (BP) response to nutrient levels 0.000000001546 Informative Direct
Biological Process (BP) regulation of transferase activity 0.000000001578 Informative Direct
Biological Process (BP) positive regulation of intracellular signal transduction 0.000000002762 Informative Direct
Biological Process (BP) regulation of protein phosphorylation 0.00000000528 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 0.000000007408 Informative Direct
Biological Process (BP) single-organism behavior 0.00000003016 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 0.00000003413 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.00000004061 Informative Direct
Biological Process (BP) regulation of system process 0.0005711 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.002369 Informative Inherited
Biological Process (BP) regulation of neurological system process 0 Highly Informative Direct
Biological Process (BP) regulation of amine transport 0 Highly Informative Direct
Biological Process (BP) G-protein coupled receptor signaling pathway 0.000000000000003707 Highly Informative Direct
Biological Process (BP) regulation of blood pressure 0.0000000000001652 Highly Informative Direct
Biological Process (BP) regulation of hormone secretion 0.0000000000004169 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 0.0000000000005468 Highly Informative Direct
Biological Process (BP) adult behavior 0.000000000002623 Highly Informative Direct
Biological Process (BP) negative regulation of response to external stimulus 0.000000000002751 Highly Informative Direct
Biological Process (BP) circadian rhythm 0.000000000002794 Highly Informative Direct
Biological Process (BP) positive regulation of protein kinase activity 0.00000000005443 Highly Informative Direct
Biological Process (BP) positive regulation of MAPK cascade 0.0000000001058 Highly Informative Direct
Biological Process (BP) regulation of response to nutrient levels 1 Highly Informative Inherited
Cellular Component (CC) extracellular region part 0.0000002829 Moderately Informative Direct
Cellular Component (CC) extracellular space 0.000000005688 Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentSecreted0Moderately InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues0Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR009106 SSF64546 Protein matches
Abstract

The cocaine and amphetamine regulated transcript (CART) is a brain-localised peptide that acts as a satiety factor in appetite regulation. CART was found to inhibit both normal and starvation-induced feeding, and completely blocks the feeding response induced by neuropeptide Y. CART is regulated by leptin in the hypothalamus, and can be transcriptionally induced after cocaine or amphetamine administration [PubMed9590691]. Posttranslational processing of CART produces an N-terminal CART peptide and a C-terminal CART peptide. The C-terminal CART peptide has been isolated from the hypothalamus, nucleus accumbens, and the anterior pituitary lobe in rats. C-terminal CART is the biologically active part of the molecule affecting food intake. The structure of C-terminal CART consists of a disulphide-bound fold containing a beta-hairpin and two adjacent disulphide bridges [PubMed11478874].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Satiety factor CART (cocaine and amphetamine regulated transcript) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Satiety factor CART (cocaine and amphetamine regulated transcript) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]