SUPERFAMILY 1.75 HMM library and genome assignments server


PX domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   PX domain [ 64267]
Superfamily:   PX domain [ 64268]
Families:   PX domain [ 64269] (5)


Superfamily statistics
Genomes (447) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 9,778 9,537 8
Proteins 9,705 9,464 8


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)localization1.41e-070Least InformativeDirect
Biological Process (BP)protein metabolic process0.00024691Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.0017961Least InformativeInherited
Biological Process (BP)biosynthetic process0.0010880.7065Least InformativeInherited
Biological Process (BP)regulation of cellular process0.40991Least InformativeInherited
Biological Process (BP)regulation of localization3.848e-060.0002571Moderately InformativeDirect
Biological Process (BP)cellular macromolecule biosynthetic process1.995e-071Moderately InformativeInherited
Biological Process (BP)ion transport0.023191Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.0016351.993e-05Moderately InformativeInherited
Biological Process (BP)organic substance transport0.10930.07781Moderately InformativeInherited
Biological Process (BP)regulation of establishment of protein localization3.296e-127.172e-05InformativeDirect
Biological Process (BP)protein transport2.413e-091.576e-13InformativeDirect
Biological Process (BP)regulation of intracellular transport0.00040.0007633InformativeDirect
Biological Process (BP)metal ion transport8.012e-100.1167InformativeInherited
Biological Process (BP)transition metal ion transport3.573e-120.0001051Highly InformativeDirect
Molecular Function (MF)binding0.000492.528e-11Least InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.021410.3625Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.024430Least InformativeInherited
Cellular Component (CC)endosome6e-110InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0001861 Least Informative Direct
Biological Process (BP) biosynthetic process 0.7065 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.9848 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.8941 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.05109 Least Informative Inherited
Biological Process (BP) regulation of localization 0.0002571 Moderately Informative Direct
Biological Process (BP) macromolecule localization 1.993e-05 Moderately Informative Direct
Biological Process (BP) cellular localization 0 Moderately Informative Direct
Biological Process (BP) cellular lipid metabolic process 2.973e-05 Moderately Informative Direct
Biological Process (BP) regulation of programmed cell death 0.876 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.405 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.1424 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.02125 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.801 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.1188 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 0.002429 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.1508 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.01235 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.04863 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.4939 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.07781 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.6226 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.4601 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.07538 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.8312 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.917 Moderately Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 7.172e-05 Informative Direct
Biological Process (BP) protein transport 1.576e-13 Informative Direct
Biological Process (BP) regulation of intracellular transport 0.0007633 Informative Direct
Biological Process (BP) vesicle-mediated transport 0 Informative Direct
Biological Process (BP) phospholipid metabolic process 2.939e-08 Informative Direct
Biological Process (BP) regulation of nucleotide catabolic process 9e-05 Informative Direct
Biological Process (BP) membrane organization 0.0001074 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 0.0001131 Informative Direct
Biological Process (BP) organelle assembly 0.0001804 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0.0002294 Informative Direct
Biological Process (BP) positive regulation of transport 0.0005353 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0.0006374 Informative Direct
Biological Process (BP) regulation of apoptotic signaling pathway 0.015 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.002893 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.003089 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.01866 Informative Inherited
Biological Process (BP) protein localization to organelle 1 Informative Inherited
Biological Process (BP) cytoplasmic transport 1 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.05456 Informative Inherited
Biological Process (BP) response to bacterium 0.01509 Informative Inherited
Biological Process (BP) metal ion transport 0.1167 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.004256 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.5218 Informative Inherited
Biological Process (BP) response to light stimulus 0.2515 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.01722 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.1977 Informative Inherited
Biological Process (BP) response to wounding 0.1654 Informative Inherited
Biological Process (BP) regulation of system process 0.004188 Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.5007 Informative Inherited
Biological Process (BP) defense response 0.09506 Informative Inherited
Biological Process (BP) immune effector process 0.04029 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.216 Informative Inherited
Biological Process (BP) cell cycle process 0.2768 Informative Inherited
Biological Process (BP) transition metal ion transport 0.0001051 Highly Informative Direct
Biological Process (BP) superoxide metabolic process 5.762e-08 Highly Informative Direct
Biological Process (BP) vesicle organization 1.587e-07 Highly Informative Direct
Biological Process (BP) positive regulation of GTPase activity 2.556e-06 Highly Informative Direct
Biological Process (BP) interaction with symbiont 3.189e-06 Highly Informative Direct
Biological Process (BP) fatty acid derivative metabolic process 8.214e-06 Highly Informative Direct
Biological Process (BP) regulation of muscle contraction 2.171e-05 Highly Informative Direct
Biological Process (BP) unsaturated fatty acid metabolic process 3.36e-05 Highly Informative Direct
Biological Process (BP) detection of light stimulus 4.225e-05 Highly Informative Direct
Biological Process (BP) small GTPase mediated signal transduction 7.056e-05 Highly Informative Direct
Biological Process (BP) glycerophospholipid biosynthetic process 7.521e-05 Highly Informative Direct
Biological Process (BP) response to fungus 0.0001768 Highly Informative Direct
Biological Process (BP) defense response to bacterium 0.0002203 Highly Informative Direct
Biological Process (BP) organelle fusion 0.0002377 Highly Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0.0003134 Highly Informative Direct
Biological Process (BP) inflammatory response 0.0005825 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic signaling pathway 0.004686 Highly Informative Inherited
Biological Process (BP) phagocytosis 0.04934 Highly Informative Inherited
Biological Process (BP) cellular membrane fusion 0.01223 Highly Informative Inherited
Biological Process (BP) modification of morphology or physiology of other organism involved in symbiotic interaction 0.02862 Highly Informative Inherited
Biological Process (BP) hydrogen peroxide metabolic process 1 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.0236 Highly Informative Inherited
Biological Process (BP) Golgi vesicle transport 0.01352 Highly Informative Inherited
Biological Process (BP) cell division 0.006155 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.02235 Highly Informative Inherited
Biological Process (BP) leukocyte mediated immunity 0.003622 Highly Informative Inherited
Molecular Function (MF) binding 2.528e-11 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.7027 Least Informative Inherited
Molecular Function (MF) anion binding 0 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.01811 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 0.3933 Moderately Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.0113 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.0027 Moderately Informative Inherited
Molecular Function (MF) lipid binding 0 Informative Direct
Molecular Function (MF) enzyme activator activity 4.943e-05 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.01151 Informative Inherited
Molecular Function (MF) kinase activity 0.003555 Informative Inherited
Molecular Function (MF) phosphoric diester hydrolase activity 0 Highly Informative Direct
Molecular Function (MF) phospholipase activity 0 Highly Informative Direct
Molecular Function (MF) phosphatidylinositol binding 1.841e-11 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0 Least Informative Direct
Cellular Component (CC) membrane 7.945e-11 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.9423 Least Informative Inherited
Cellular Component (CC) protein complex 0.006921 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.3625 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) organelle membrane 1.521e-15 Moderately Informative Direct
Cellular Component (CC) vesicle 5.046e-09 Moderately Informative Direct
Cellular Component (CC) endomembrane system 8.557e-05 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 1 Moderately Informative Inherited
Cellular Component (CC) plasma membrane part 0.1025 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.01667 Moderately Informative Inherited
Cellular Component (CC) endosome 0 Informative Direct
Cellular Component (CC) intrinsic to plasma membrane 0.8438 Informative Inherited
Cellular Component (CC) integral to membrane 0.9123 Informative Inherited
Cellular Component (CC) actin cytoskeleton 0.3824 Informative Inherited
Cellular Component (CC) endosomal part 0 Highly Informative Direct
Cellular Component (CC) internal side of plasma membrane 8.75e-06 Highly Informative Direct
Cellular Component (CC) extrinsic to plasma membrane 0.0003086 Highly Informative Direct
Cellular Component (CC) integral to plasma membrane 0.2005 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds5.668e-07Least InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases9.895e-05Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0.008197Moderately InformativeInherited
Enzyme Commission (EC)Phosphatidylinositol-4-phosphate 3-kinase0Highly InformativeDirect
Enzyme Commission (EC)Phospholipase D0Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of head and neck0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the skeletal system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the abdomen0.1159Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.154Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the mouth0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the skull0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the immune system0.03494Moderately InformativeInherited
Phenotypic Abnormality (PA)Generalized abnormality of skin0.04251Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the respiratory system0.04484Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.06463Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the oral cavity0InformativeDirect
Phenotypic Abnormality (PA)Abnormality of facial skeleton0InformativeDirect
Phenotypic Abnormality (PA)Abnormal eye physiology0InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the lymph nodes3.371e-05InformativeDirect
Phenotypic Abnormality (PA)Vascular skin abnormality0.0009301InformativeDirect
Phenotypic Abnormality (PA)Respiratory tract infection0.0009833InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the spleen0.001436InformativeInherited
Phenotypic Abnormality (PA)Recurrent infections0.00251InformativeInherited
Phenotypic Abnormality (PA)Visceromegaly0.004083InformativeInherited
Phenotypic Abnormality (PA)Sinusitis4.995e-06Highly InformativeDirect
Phenotypic Abnormality (PA)Lymphadenopathy2.537e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of temperature regulation0.0001791Highly InformativeDirect
Phenotypic Abnormality (PA)Recurrent respiratory infections0.0008206Highly InformativeDirect

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0Least InformativeDirect
Worm Phenotype (WP)cell death variant0Moderately InformativeDirect
Worm Phenotype (WP)sensillum morphology variant0.0004604InformativeDirect
Worm Phenotype (WP)cell corpse number variant0.0004672InformativeDirect
Worm Phenotype (WP)accumulated germline cell corpses0Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups4.021e-07Least InformativeDirect
Enzyme Commission (EC)Hydrolases0.009574Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases9.418e-05Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0.009003Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases0InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase9.235e-10InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-4-phosphate 3-kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processProtein transport0Moderately InformativeDirect
Biological processLipid metabolism0.1725Moderately InformativeInherited
Biological processCell cycle0.3168Moderately InformativeInherited
Biological processEndocytosis0InformativeDirect
Biological processMitosis5.964e-07InformativeDirect
Biological processAutophagy0Highly InformativeDirect
Biological processLipid degradation2.417e-08Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentEndosome0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0Moderately InformativeDirect
Cellular componentCell projection2.616e-09Moderately InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainSH3 domain0InformativeDirect
Molecular functionLipid-binding0InformativeDirect
Post-translational modificationGTPase activation5.034e-08InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation1.645e-06Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR001683 SSF64268 Protein matches
Abstract

The PX (phox) domain [PubMed8931154] occurs in a variety of eukaryotic proteins and have been implicated in highly diverse functions such as cell signalling, vesicular trafficking, protein sorting and lipid modification [PubMed10782093, PubMed11736640, PubMed12461558]. PX domains are important phosphoinositide-binding modules that have varying lipid-binding specificities [PubMed11884510]. The PX domain is approximately 120 residues long [PubMed11373621], and folds into a three-stranded beta-sheet followed by three -helices and a proline-rich region that immediately preceeds a membrane-interaction loop and spans approximately eight hydrophobic and polar residues. The PX domain of p47phox binds to the SH3 domain in the same protein [PubMed11373621]. Phosphorylation of p47(phox), a cytoplasmic activator of the microbicidal phagocyte oxidase (phox), elicits interaction of p47(phox) with phoinositides. The protein phosphorylation-driven conformational change of p47(phox) enables its PX domain to bind to phosphoinositides, the interaction of which plays a crucial role in recruitment of p47(phox) from the cytoplasm to membranes and subsequent activation of the phagocyte oxidase. The lipid-binding activity of this protein is normally suppressed by intramolecular interaction of the PX domain with the C-terminal Src homology 3 (SH3) domain [PubMed12356722].

The PX domain is conserved from yeast to human. A recent multiple alignment of representative PX domain sequences can be found in [PubMed9687503], although showing relatively little sequence conservation, their structure appears to be highly conserved. Although phosphatidylinositol-3-phosphate (PtdIns(3)P) is the primary target of PX domains, binding to phosphatidic acid, phosphatidylinositol-3,4-bisphosphate (PtdIns(3,4)P2), phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2), phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2), and phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) has been reported as well. The PX-domain is also a protein-protein interaction domain [PubMed15263065].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a PX domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the PX domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]