SUPERFAMILY 1.75 HMM library and genome assignments server

PX domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   PX domain [ 64267]
Superfamily:   PX domain [ 64268]
Families:   PX domain [ 64269] (5)


Superfamily statistics
Genomes (499) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 10,907 14,409 8
Proteins 10,823 14,322 8


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)localization0.00000047180Least InformativeDirect
Biological Process (BP)regulation of cellular process0.40481Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.0016111Least InformativeInherited
Biological Process (BP)biosynthetic process0.001160.7076Least InformativeInherited
Biological Process (BP)protein metabolic process0.0002581Least InformativeInherited
Biological Process (BP)regulation of localization0.0000011120.0000103Moderately InformativeDirect
Biological Process (BP)macromolecule localization0.0014020.000001992Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process0.00000022211Moderately InformativeInherited
Biological Process (BP)organic substance transport0.092970.02408Moderately InformativeInherited
Biological Process (BP)ion transport0.036531Moderately InformativeInherited
Biological Process (BP)protein transport0.0005890.00000000004441InformativeDirect
Biological Process (BP)metal ion transport0.00000000078850.1354InformativeInherited
Biological Process (BP)transition metal ion transport0.000000000003170.0001218Highly InformativeDirect
Molecular Function (MF)binding0.00057320.0000000001194Least InformativeDirect
Molecular Function (MF)anion binding0.0031150Moderately InformativeInherited
Molecular Function (MF)lipid binding0.0017940InformativeInherited
Molecular Function (MF)phosphatidylinositol binding0.000000083530.00000000002132Highly InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.0075680.3393Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.0083810.00000000000000457Least InformativeInherited
Cellular Component (CC)endosome0.0000000000011510InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.7076 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.05512 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) positive regulation of biological process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) lipid metabolic process 0.0001544 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.0000103 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.000001992 Moderately Informative Direct
Biological Process (BP) cellular localization 0.0000004527 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.4162 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.7667 Moderately Informative Inherited
Biological Process (BP) defense response 0.05236 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.2911 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.4477 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.5233 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.2304 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.05295 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.02408 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.1163 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.9596 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.5848 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) single-organism organelle organization 0.4825 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.4444 Moderately Informative Inherited
Biological Process (BP) regulation of phosphorus metabolic process 0.3436 Moderately Informative Inherited
Biological Process (BP) immune system process 0.1371 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.9823 Moderately Informative Inherited
Biological Process (BP) phospholipid metabolic process 0.00000003467 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 0.0001719 Informative Direct
Biological Process (BP) protein transport 0.00000000004441 Informative Direct
Biological Process (BP) vesicle-mediated transport 0 Informative Direct
Biological Process (BP) single-organism membrane organization 0.000002723 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0.0004148 Informative Direct
Biological Process (BP) positive regulation of transport 0.0008467 Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0.0000293 Informative Direct
Biological Process (BP) organelle assembly 0.0003833 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0.0009197 Informative Direct
Biological Process (BP) single-organism intracellular transport 0.000000003776 Informative Direct
Biological Process (BP) negative regulation of signaling 0.02384 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.8212 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.3763 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.009575 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.05036 Informative Inherited
Biological Process (BP) regulation of system process 0.008758 Informative Inherited
Biological Process (BP) defense response to other organism 0.002212 Informative Inherited
Biological Process (BP) response to bacterium 0.008007 Informative Inherited
Biological Process (BP) regulation of protein localization 0.02403 Informative Inherited
Biological Process (BP) regulation of secretion 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.6877 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.01099 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.002302 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.3433 Informative Inherited
Biological Process (BP) positive regulation of catabolic process 0.001041 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.5255 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 0.00438 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.1219 Informative Inherited
Biological Process (BP) cytoplasmic transport 1 Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.2934 Informative Inherited
Biological Process (BP) cell cycle process 0.08947 Informative Inherited
Biological Process (BP) response to light stimulus 0.2784 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.1367 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.02541 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.2571 Informative Inherited
Biological Process (BP) protein localization to organelle 1 Informative Inherited
Biological Process (BP) single-organism cellular localization 0.7977 Informative Inherited
Biological Process (BP) immune effector process 0.01468 Informative Inherited
Biological Process (BP) cell division 0.06723 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.8002 Informative Inherited
Biological Process (BP) metal ion transport 0.1354 Informative Inherited
Biological Process (BP) transition metal ion transport 0.0001218 Highly Informative Direct
Biological Process (BP) cytokinesis 0.00001878 Highly Informative Direct
Biological Process (BP) icosanoid metabolic process 0.000000736 Highly Informative Direct
Biological Process (BP) superoxide metabolic process 0.0000001487 Highly Informative Direct
Biological Process (BP) inflammatory response 0.0006627 Highly Informative Direct
Biological Process (BP) small GTPase mediated signal transduction 0.00006996 Highly Informative Direct
Biological Process (BP) detection of light stimulus 0.00003667 Highly Informative Direct
Biological Process (BP) response to fungus 0.00003208 Highly Informative Direct
Biological Process (BP) vesicle organization 0.0000002193 Highly Informative Direct
Biological Process (BP) unsaturated fatty acid metabolic process 0.000003725 Highly Informative Direct
Biological Process (BP) modification of morphology or physiology of other organism 0.00007971 Highly Informative Direct
Biological Process (BP) defense response to bacterium 0.0001215 Highly Informative Direct
Biological Process (BP) positive regulation of GTPase activity 0.0002565 Highly Informative Direct
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.000836 Highly Informative Direct
Biological Process (BP) glycerophospholipid biosynthetic process 0.00006493 Highly Informative Direct
Biological Process (BP) organelle fusion 0.0004659 Highly Informative Direct
Biological Process (BP) regulation of muscle system process 0.00001352 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic signaling pathway 0.001652 Highly Informative Inherited
Biological Process (BP) plasma membrane organization 0.447 Highly Informative Inherited
Biological Process (BP) phagocytosis 0.04366 Highly Informative Inherited
Biological Process (BP) positive regulation of protein secretion 0.001966 Highly Informative Inherited
Biological Process (BP) hydrogen peroxide metabolic process 0.8987 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.04919 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.1227 Highly Informative Inherited
Biological Process (BP) Golgi vesicle transport 0.1726 Highly Informative Inherited
Biological Process (BP) membrane fusion 0.1091 Highly Informative Inherited
Biological Process (BP) leukocyte mediated immunity 0.001498 Highly Informative Inherited
Molecular Function (MF) binding 0.0000000001194 Least Informative Direct
Molecular Function (MF) transferase activity 0.9607 Least Informative Inherited
Molecular Function (MF) hydrolase activity 0.7703 Least Informative Inherited
Molecular Function (MF) anion binding 0 Moderately Informative Direct
Molecular Function (MF) oxidoreductase activity 0.3102 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.02383 Moderately Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.002917 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.004168 Moderately Informative Inherited
Molecular Function (MF) enzyme activator activity 0.0005954 Informative Direct
Molecular Function (MF) lipid binding 0 Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on NAD(P)H 0.000000000005615 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.01051 Informative Inherited
Molecular Function (MF) kinase activity 0.004647 Informative Inherited
Molecular Function (MF) small GTPase regulator activity 0.0002723 Highly Informative Direct
Molecular Function (MF) phosphoric diester hydrolase activity 0 Highly Informative Direct
Molecular Function (MF) lipase activity 0.000000000000006187 Highly Informative Direct
Molecular Function (MF) phosphatidylinositol binding 0.00000000002132 Highly Informative Direct
Cellular Component (CC) membrane 0.000000002279 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.00000000000000457 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.3393 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.863 Least Informative Inherited
Cellular Component (CC) protein complex 0.001276 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) vesicle 0.00000005965 Moderately Informative Direct
Cellular Component (CC) bounding membrane of organelle 0.00003369 Moderately Informative Direct
Cellular Component (CC) intrinsic component of membrane 1 Moderately Informative Inherited
Cellular Component (CC) plasma membrane part 0.1704 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.003729 Moderately Informative Inherited
Cellular Component (CC) endosome 0 Informative Direct
Cellular Component (CC) oxidoreductase complex 0.00001142 Informative Direct
Cellular Component (CC) integral component of membrane 1 Informative Inherited
Cellular Component (CC) intrinsic component of plasma membrane 0.7907 Informative Inherited
Cellular Component (CC) actin cytoskeleton 0.4229 Informative Inherited
Cellular Component (CC) extrinsic component of cytoplasmic side of plasma membrane 0.0000002221 Highly Informative Direct
Cellular Component (CC) endosomal part 0 Highly Informative Direct
Cellular Component (CC) integral component of plasma membrane 0.6791 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.0000005668Least InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.00009895Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0.008197Moderately InformativeInherited
Enzyme Commission (EC)Phosphatidylinositol-4-phosphate 3-kinase0Highly InformativeDirect
Enzyme Commission (EC)Phospholipase D0Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of head and neck0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the abdomen0.1142Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.1507Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the mouth0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the skull0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0.02834Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the immune system0.03449Moderately InformativeInherited
Phenotypic Abnormality (PA)Generalized abnormality of skin0.04172Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the oral cavity0InformativeDirect
Phenotypic Abnormality (PA)Abnormality of facial skeleton0InformativeDirect
Phenotypic Abnormality (PA)Abnormal eye physiology0InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the lymph nodes0.00003343InformativeDirect
Phenotypic Abnormality (PA)Abnormality of temperature regulation0.0001757InformativeDirect
Phenotypic Abnormality (PA)Vascular skin abnormality0.00087InformativeDirect
Phenotypic Abnormality (PA)Respiratory tract infection0.001039InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the spleen0.00135InformativeInherited
Phenotypic Abnormality (PA)Recurrent infections0.002573InformativeInherited
Phenotypic Abnormality (PA)Visceromegaly0.00387InformativeInherited
Phenotypic Abnormality (PA)Sinusitis0.00000595Highly InformativeDirect
Phenotypic Abnormality (PA)Lymphadenopathy0.00002517Highly InformativeDirect
Phenotypic Abnormality (PA)Recurrent respiratory infections0.0008865Highly InformativeDirect

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0Least InformativeDirect
Worm Phenotype (WP)cell death variant0Moderately InformativeDirect
Worm Phenotype (WP)sensillum morphology variant0.0004604InformativeDirect
Worm Phenotype (WP)cell corpse number variant0.0004672InformativeDirect
Worm Phenotype (WP)accumulated germline cell corpses0Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0.0000003504Least InformativeDirect
Enzyme Commission (EC)Hydrolases0.009252Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0.00009392Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0.009195Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases0InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0.000000000863InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-4-phosphate 3-kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details) Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processProtein transport0Moderately InformativeDirect
Biological processLipid metabolism0.1738Moderately InformativeInherited
Biological processCell cycle0.3027Moderately InformativeInherited
Biological processEndocytosis0InformativeDirect
Biological processMitosis0.0000005085InformativeDirect
Biological processAutophagy0Highly InformativeDirect
Biological processLipid degradation0.00000002479Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentEndosome0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0Moderately InformativeDirect
Cellular componentCell projection0.000000003613Moderately InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainSH3 domain0InformativeDirect
Molecular functionLipid-binding0InformativeDirect
Post-translational modificationGTPase activation0.00000004429InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation0.000001695Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR001683 SSF64268 Protein matches
Abstract

The PX (phox) domain [PubMed8931154] occurs in a variety of eukaryotic proteins and have been implicated in highly diverse functions such as cell signalling, vesicular trafficking, protein sorting and lipid modification [PubMed10782093, PubMed11736640, PubMed12461558]. PX domains are important phosphoinositide-binding modules that have varying lipid-binding specificities [PubMed11884510]. The PX domain is approximately 120 residues long [PubMed11373621], and folds into a three-stranded beta-sheet followed by three -helices and a proline-rich region that immediately preceeds a membrane-interaction loop and spans approximately eight hydrophobic and polar residues. The PX domain of p47phox binds to the SH3 domain in the same protein [PubMed11373621]. Phosphorylation of p47(phox), a cytoplasmic activator of the microbicidal phagocyte oxidase (phox), elicits interaction of p47(phox) with phoinositides. The protein phosphorylation-driven conformational change of p47(phox) enables its PX domain to bind to phosphoinositides, the interaction of which plays a crucial role in recruitment of p47(phox) from the cytoplasm to membranes and subsequent activation of the phagocyte oxidase. The lipid-binding activity of this protein is normally suppressed by intramolecular interaction of the PX domain with the C-terminal Src homology 3 (SH3) domain [PubMed12356722].

The PX domain is conserved from yeast to human. A recent multiple alignment of representative PX domain sequences can be found in [PubMed9687503], although showing relatively little sequence conservation, their structure appears to be highly conserved. Although phosphatidylinositol-3-phosphate (PtdIns(3)P) is the primary target of PX domains, binding to phosphatidic acid, phosphatidylinositol-3,4-bisphosphate (PtdIns(3,4)P2), phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2), phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2), and phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) has been reported as well. The PX-domain is also a protein-protein interaction domain [PubMed15263065].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a PX domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the PX domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · Internal database links ]