SUPERFAMILY 1.75 HMM library and genome assignments server


PX domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   PX domain [ 64267]
Superfamily:   PX domain [ 64268]
Families:   PX domain [ 64269] (5)


Superfamily statistics
Genomes (498) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 10,884 14,409 8
Proteins 10,800 14,322 8


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)localization3.231e-070Least InformativeDirect
Biological Process (BP)protein metabolic process0.00023221Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.001791Least InformativeInherited
Biological Process (BP)biosynthetic process0.0011660.7003Least InformativeInherited
Biological Process (BP)regulation of cellular process0.34061Least InformativeInherited
Biological Process (BP)regulation of localization9.04e-074.057e-05Moderately InformativeDirect
Biological Process (BP)cellular macromolecule biosynthetic process2.205e-071Moderately InformativeInherited
Biological Process (BP)ion transport0.022461Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.0018116.938e-06Moderately InformativeInherited
Biological Process (BP)organic substance transport0.10920.04017Moderately InformativeInherited
Biological Process (BP)protein transport2.436e-097.829e-14InformativeDirect
Biological Process (BP)regulation of intracellular transport9.351e-050.0008988InformativeDirect
Biological Process (BP)metal ion transport7.936e-100.1351InformativeInherited
Biological Process (BP)transition metal ion transport3.209e-120.0001216Highly InformativeDirect
Molecular Function (MF)binding0.00051679.873e-11Least InformativeDirect
Molecular Function (MF)anion binding0.0031070Moderately InformativeInherited
Molecular Function (MF)lipid binding0.0018290InformativeInherited
Molecular Function (MF)phosphatidylinositol binding8.347e-081.681e-11Highly InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.0090510.6066Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.0086743.101e-15Least InformativeInherited
Cellular Component (CC)endosome1.003e-120InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 0.0002777 Least Informative Direct
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) biosynthetic process 0.7003 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.9832 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.8923 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.06636 Least Informative Inherited
Biological Process (BP) regulation of localization 4.057e-05 Moderately Informative Direct
Biological Process (BP) macromolecule localization 6.938e-06 Moderately Informative Direct
Biological Process (BP) cellular lipid metabolic process 1.462e-05 Moderately Informative Direct
Biological Process (BP) cellular localization 0 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.4056 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.1363 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.02764 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.7138 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 0.003236 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.1093 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.1712 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.232 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.04826 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.3269 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.04017 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.5625 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.3222 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.09106 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.8716 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.9773 Moderately Informative Inherited
Biological Process (BP) phospholipid metabolic process 3.126e-08 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 0.0001467 Informative Direct
Biological Process (BP) protein transport 7.829e-14 Informative Direct
Biological Process (BP) cellular membrane organization 0.0001377 Informative Direct
Biological Process (BP) vesicle-mediated transport 1.936e-15 Informative Direct
Biological Process (BP) regulation of intracellular transport 0.0008988 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0.0003926 Informative Direct
Biological Process (BP) positive regulation of transport 0.0002776 Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 1.863e-05 Informative Direct
Biological Process (BP) organelle assembly 0.0003579 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0.000776 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.8122 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.004884 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.01084 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.02724 Informative Inherited
Biological Process (BP) protein localization to organelle 1 Informative Inherited
Biological Process (BP) response to other organism 0.4188 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 0.09602 Informative Inherited
Biological Process (BP) regulation of secretion 1 Informative Inherited
Biological Process (BP) cytoplasmic transport 1 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 0.001938 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.1268 Informative Inherited
Biological Process (BP) metal ion transport 0.1351 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.006245 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.5889 Informative Inherited
Biological Process (BP) response to light stimulus 0.273 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.02308 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.2112 Informative Inherited
Biological Process (BP) response to wounding 0.09573 Informative Inherited
Biological Process (BP) regulation of system process 0.00192 Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.3711 Informative Inherited
Biological Process (BP) defense response 0.07203 Informative Inherited
Biological Process (BP) immune effector process 0.01467 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.139 Informative Inherited
Biological Process (BP) cell cycle process 0.3588 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.4816 Informative Inherited
Biological Process (BP) transition metal ion transport 0.0001216 Highly Informative Direct
Biological Process (BP) icosanoid metabolic process 7.48e-07 Highly Informative Direct
Biological Process (BP) superoxide metabolic process 1.456e-07 Highly Informative Direct
Biological Process (BP) regulation of muscle contraction 2.211e-06 Highly Informative Direct
Biological Process (BP) inflammatory response 0.0001286 Highly Informative Direct
Biological Process (BP) small GTPase mediated signal transduction 7.308e-05 Highly Informative Direct
Biological Process (BP) detection of light stimulus 4.392e-05 Highly Informative Direct
Biological Process (BP) response to fungus 3.286e-05 Highly Informative Direct
Biological Process (BP) vesicle organization 1.867e-07 Highly Informative Direct
Biological Process (BP) unsaturated fatty acid metabolic process 3.712e-06 Highly Informative Direct
Biological Process (BP) modification of morphology or physiology of other organism 7.893e-05 Highly Informative Direct
Biological Process (BP) defense response to bacterium 6.647e-05 Highly Informative Direct
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.0007195 Highly Informative Direct
Biological Process (BP) glycerophospholipid biosynthetic process 6.91e-05 Highly Informative Direct
Biological Process (BP) organelle fusion 0.0003313 Highly Informative Direct
Biological Process (BP) positive regulation of protein secretion 0.0002227 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic signaling pathway 0.004169 Highly Informative Inherited
Biological Process (BP) membrane fusion 0.07561 Highly Informative Inherited
Biological Process (BP) phagocytosis 0.04885 Highly Informative Inherited
Biological Process (BP) establishment of protein localization to organelle 1 Highly Informative Inherited
Biological Process (BP) hydrogen peroxide metabolic process 0.9004 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.008766 Highly Informative Inherited
Biological Process (BP) Golgi vesicle transport 0.01256 Highly Informative Inherited
Biological Process (BP) cell division 0.005534 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.02908 Highly Informative Inherited
Biological Process (BP) leukocyte mediated immunity 0.001349 Highly Informative Inherited
Molecular Function (MF) binding 9.873e-11 Least Informative Direct
Molecular Function (MF) transferase activity 0.7796 Least Informative Inherited
Molecular Function (MF) hydrolase activity 0.7606 Least Informative Inherited
Molecular Function (MF) anion binding 0 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.02403 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 0.3017 Moderately Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.01408 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.003513 Moderately Informative Inherited
Molecular Function (MF) enzyme activator activity 4.983e-05 Informative Direct
Molecular Function (MF) lipid binding 0 Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on NAD(P)H 5.667e-12 Informative Direct
Molecular Function (MF) phosphoric ester hydrolase activity 1.75e-06 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.01052 Informative Inherited
Molecular Function (MF) kinase activity 0.004811 Informative Inherited
Molecular Function (MF) phosphoric diester hydrolase activity 0 Highly Informative Direct
Molecular Function (MF) lipase activity 6.799e-15 Highly Informative Direct
Molecular Function (MF) phosphatidylinositol binding 1.681e-11 Highly Informative Direct
Cellular Component (CC) membrane 1.632e-09 Least Informative Direct
Cellular Component (CC) cytoplasmic part 3.101e-15 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.9409 Least Informative Inherited
Cellular Component (CC) protein complex 0.004126 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.6066 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) endomembrane system 0.0001555 Moderately Informative Direct
Cellular Component (CC) organelle membrane 3.101e-15 Moderately Informative Direct
Cellular Component (CC) vesicle 5.497e-08 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 1 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 0.6551 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.002493 Moderately Informative Inherited
Cellular Component (CC) endosome 0 Informative Direct
Cellular Component (CC) integral to membrane 0.9468 Informative Inherited
Cellular Component (CC) intrinsic to plasma membrane 0.8642 Informative Inherited
Cellular Component (CC) actin cytoskeleton 0.4621 Informative Inherited
Cellular Component (CC) extrinsic to plasma membrane 0.0002966 Highly Informative Direct
Cellular Component (CC) endosomal part 0 Highly Informative Direct
Cellular Component (CC) integral to plasma membrane 0.2319 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds5.668e-07Least InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases9.895e-05Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0.008197Moderately InformativeInherited
Enzyme Commission (EC)Phosphatidylinositol-4-phosphate 3-kinase0Highly InformativeDirect
Enzyme Commission (EC)Phospholipase D0Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of head and neck0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the abdomen0.1143Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.1507Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the mouth0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the skull0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0.02841Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the immune system0.03459Moderately InformativeInherited
Phenotypic Abnormality (PA)Generalized abnormality of skin0.04186Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the oral cavity0InformativeDirect
Phenotypic Abnormality (PA)Abnormality of facial skeleton0InformativeDirect
Phenotypic Abnormality (PA)Abnormal eye physiology0InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the lymph nodes3.392e-05InformativeDirect
Phenotypic Abnormality (PA)Abnormality of temperature regulation0.000178InformativeDirect
Phenotypic Abnormality (PA)Vascular skin abnormality0.0008772InformativeDirect
Phenotypic Abnormality (PA)Respiratory tract infection0.001048InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the spleen0.001362InformativeInherited
Phenotypic Abnormality (PA)Recurrent infections0.002589InformativeInherited
Phenotypic Abnormality (PA)Visceromegaly0.003897InformativeInherited
Phenotypic Abnormality (PA)Sinusitis6.051e-06Highly InformativeDirect
Phenotypic Abnormality (PA)Lymphadenopathy2.552e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Recurrent respiratory infections0.0008931Highly InformativeDirect

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0Least InformativeDirect
Worm Phenotype (WP)cell death variant0Moderately InformativeDirect
Worm Phenotype (WP)sensillum morphology variant0.0004604InformativeDirect
Worm Phenotype (WP)cell corpse number variant0.0004672InformativeDirect
Worm Phenotype (WP)accumulated germline cell corpses0Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups3.571e-07Least InformativeDirect
Enzyme Commission (EC)Hydrolases0.009285Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases9.361e-05Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0.00914Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases0InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase8.598e-10InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-4-phosphate 3-kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processProtein transport0Moderately InformativeDirect
Biological processLipid metabolism0.1739Moderately InformativeInherited
Biological processCell cycle0.3138Moderately InformativeInherited
Biological processEndocytosis0InformativeDirect
Biological processMitosis5.779e-07InformativeDirect
Biological processAutophagy0Highly InformativeDirect
Biological processLipid degradation2.505e-08Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentEndosome0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0Moderately InformativeDirect
Cellular componentCell projection3.351e-09Moderately InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainSH3 domain0InformativeDirect
Molecular functionLipid-binding0InformativeDirect
Post-translational modificationGTPase activation4.872e-08InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation1.687e-06Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR001683 SSF64268 Protein matches
Abstract

The PX (phox) domain [PubMed8931154] occurs in a variety of eukaryotic proteins and have been implicated in highly diverse functions such as cell signalling, vesicular trafficking, protein sorting and lipid modification [PubMed10782093, PubMed11736640, PubMed12461558]. PX domains are important phosphoinositide-binding modules that have varying lipid-binding specificities [PubMed11884510]. The PX domain is approximately 120 residues long [PubMed11373621], and folds into a three-stranded beta-sheet followed by three -helices and a proline-rich region that immediately preceeds a membrane-interaction loop and spans approximately eight hydrophobic and polar residues. The PX domain of p47phox binds to the SH3 domain in the same protein [PubMed11373621]. Phosphorylation of p47(phox), a cytoplasmic activator of the microbicidal phagocyte oxidase (phox), elicits interaction of p47(phox) with phoinositides. The protein phosphorylation-driven conformational change of p47(phox) enables its PX domain to bind to phosphoinositides, the interaction of which plays a crucial role in recruitment of p47(phox) from the cytoplasm to membranes and subsequent activation of the phagocyte oxidase. The lipid-binding activity of this protein is normally suppressed by intramolecular interaction of the PX domain with the C-terminal Src homology 3 (SH3) domain [PubMed12356722].

The PX domain is conserved from yeast to human. A recent multiple alignment of representative PX domain sequences can be found in [PubMed9687503], although showing relatively little sequence conservation, their structure appears to be highly conserved. Although phosphatidylinositol-3-phosphate (PtdIns(3)P) is the primary target of PX domains, binding to phosphatidic acid, phosphatidylinositol-3,4-bisphosphate (PtdIns(3,4)P2), phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2), phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2), and phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) has been reported as well. The PX-domain is also a protein-protein interaction domain [PubMed15263065].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a PX domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the PX domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]