SUPERFAMILY 1.75 HMM library and genome assignments server

MTH938-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   MTH938-like [ 64075]
Superfamily:   MTH938-like [ 64076]
Families:   MTH938-like [ 64077] (5)


Superfamily statistics
Genomes (847) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,023 2,112 5
Proteins 1,023 2,112 5


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)positive regulation of biological process0.00000017960.01641Least InformativeInherited
Biological Process (BP)regulation of cellular process0.000034340.3847Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.0000003250.04603Least InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.00000000071920.0006933Moderately InformativeDirect
Biological Process (BP)regulation of developmental process0.000000000033310.00005604Moderately InformativeDirect
Biological Process (BP)regulation of macromolecule biosynthetic process0.00000000010460.001385Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.00000000045890.003Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.0000000024220.004393Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.000000027920.007077Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.000000016130.002973Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.00000000025520.002Moderately InformativeInherited
Biological Process (BP)regulation of transcription from RNA polymerase II promoter0.000000000000041990.000006725InformativeDirect
Biological Process (BP)positive regulation of macromolecule biosynthetic process0.000000000000074980.000005313InformativeDirect
Biological Process (BP)positive regulation of gene expression0.00000000000052150.00001252InformativeDirect
Biological Process (BP)positive regulation of cellular biosynthetic process0.00000000000024390.000009498InformativeDirect
Biological Process (BP)regulation of apoptotic process0.0000000000022160.0000002402InformativeDirect
Biological Process (BP)positive regulation of developmental process0.000000000000031770.00000005142InformativeDirect
Biological Process (BP)positive regulation of RNA metabolic process0.000000000000024410.000003252InformativeDirect
Biological Process (BP)negative regulation of cell death0.00000000000014320.00000001069InformativeDirect
Biological Process (BP)positive regulation of transcription, DNA-templated0.000000000000018460.000002406Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) positive regulation of biological process 0.01641 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.3847 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.04603 Least Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.0006933 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.00005604 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0.001385 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.003 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.004393 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.007077 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.002973 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.002 Moderately Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.000006725 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.000005313 Informative Direct
Biological Process (BP) positive regulation of gene expression 0.00001252 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0.000009498 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.0000002402 Informative Direct
Biological Process (BP) positive regulation of developmental process 0.00000005142 Informative Direct
Biological Process (BP) positive regulation of RNA metabolic process 0.000003252 Informative Direct
Biological Process (BP) negative regulation of cell death 0.00000001069 Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-templated 0.000002406 Highly Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentNucleus0.0001423Least InformativeDirect
Cellular componentMitochondrion0.0000003003Moderately InformativeDirect
Cellular componentMitochondrion inner membrane0.00000000002706InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR007523 SSF64076 Protein matches
Abstract

This is a family of uncharacterised proteins possibly involved in DNA repair.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a MTH938-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the MTH938-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]