SUPERFAMILY 1.75 HMM library and genome assignments server

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MTH938-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   MTH938-like [ 64075]
Superfamily:   MTH938-like [ 64076]
Families:   MTH938-like [ 64077] (5)

Superfamily statistics
Genomes (718) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 894 1,287 5
Proteins 894 1,287 5

 Functional annotation
General category Other
Detailed category Unknown function

Document: Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process4.201e-050.2829Least InformativeInherited
Biological Process (BP)regulation of developmental process3.438e-111.735e-05Moderately InformativeDirect
Biological Process (BP)positive regulation of cellular process1.58e-080.00197Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process1.536e-080.001195Moderately InformativeInherited
Biological Process (BP)regulation of apoptotic process6.901e-121.631e-07InformativeDirect
Biological Process (BP)positive regulation of developmental process1.34e-145.41e-09InformativeDirect
Biological Process (BP)negative regulation of cell death1.503e-132.955e-09InformativeDirect
Biological Process (BP)negative regulation of apoptotic process5.404e-141.051e-09Highly InformativeDirect
Biological Process (BP)positive regulation of cell differentiation01.365e-10Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 0.2829 Least Informative Inherited
Biological Process (BP) regulation of developmental process 1.735e-05 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.00197 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.001195 Moderately Informative Inherited
Biological Process (BP) regulation of apoptotic process 1.631e-07 Informative Direct
Biological Process (BP) positive regulation of developmental process 5.41e-09 Informative Direct
Biological Process (BP) negative regulation of cell death 2.955e-09 Informative Direct
Biological Process (BP) negative regulation of apoptotic process 1.051e-09 Highly Informative Direct
Biological Process (BP) positive regulation of cell differentiation 1.365e-10 Highly Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentNucleus0.0001389Least InformativeDirect
Cellular componentMitochondrion3.034e-07Moderately InformativeDirect
Cellular componentMitochondrion inner membrane2.758e-11InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR007523 SSF64076 Protein matches
Abstract

This is a family of uncharacterised proteins possibly involved in DNA repair.


InterPro database

PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a MTH938-like domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the MTH938-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]
Please cite: Gough, J., Karplus, K., Hughey, R. and Chothia, C. (2001). "Assignment of Homology to Genome Sequences using a Library of Hidden Markov Models that Represent all Proteins of Known Structure." J. Mol. Biol., 313(4), 903-919.

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© Copyright 2013 The SUPERFAMILY authors and Julian Gough.