SUPERFAMILY 1.75 HMM library and genome assignments server


MTH938-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   MTH938-like [ 64075]
Superfamily:   MTH938-like [ 64076]
Families:   MTH938-like [ 64077] (5)


Superfamily statistics
Genomes (838) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,008 0 5
Proteins 1,008 0 5


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of metabolic process1.839e-070.03757Least InformativeInherited
Biological Process (BP)regulation of cellular process2.199e-050.3585Least InformativeInherited
Biological Process (BP)positive regulation of metabolic process3.374e-110.0001389Moderately InformativeDirect
Biological Process (BP)regulation of developmental process2.472e-114.926e-05Moderately InformativeDirect
Biological Process (BP)positive regulation of cellular process9.061e-090.003883Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process3.239e-100.002672Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process6.268e-090.0021Moderately InformativeInherited
Biological Process (BP)regulation of biosynthetic process2.559e-100.002121Moderately InformativeInherited
Biological Process (BP)regulation of gene expression3.179e-100.002743Moderately InformativeInherited
Biological Process (BP)regulation of transcription from RNA polymerase II promoter3.069e-145.9e-06InformativeDirect
Biological Process (BP)positive regulation of macromolecule biosynthetic process5.084e-144.767e-06InformativeDirect
Biological Process (BP)positive regulation of gene expression4.949e-143.573e-06InformativeDirect
Biological Process (BP)positive regulation of cellular biosynthetic process1.351e-138.398e-06InformativeDirect
Biological Process (BP)regulation of apoptotic process1.641e-122.16e-07InformativeDirect
Biological Process (BP)positive regulation of developmental process9.589e-152.185e-08InformativeDirect
Biological Process (BP)positive regulation of nitrogen compound metabolic process1.13e-136.649e-06InformativeDirect
Biological Process (BP)negative regulation of cell death3.804e-143.192e-09InformativeDirect
Biological Process (BP)negative regulation of apoptotic process1.116e-149.184e-10Highly InformativeDirect
Biological Process (BP)positive regulation of cell differentiation06.826e-10Highly InformativeDirect
Biological Process (BP)positive regulation of transcription, DNA-dependent1.116e-142.027e-06Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of metabolic process 0.03757 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.3585 Least Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.0001389 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 4.926e-05 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.003883 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.002672 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.0021 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 0.002121 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.002743 Moderately Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 5.9e-06 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 4.767e-06 Informative Direct
Biological Process (BP) positive regulation of gene expression 3.573e-06 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 8.398e-06 Informative Direct
Biological Process (BP) regulation of apoptotic process 2.16e-07 Informative Direct
Biological Process (BP) positive regulation of developmental process 2.185e-08 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 6.649e-06 Informative Direct
Biological Process (BP) negative regulation of cell death 3.192e-09 Informative Direct
Biological Process (BP) negative regulation of apoptotic process 9.184e-10 Highly Informative Direct
Biological Process (BP) positive regulation of cell differentiation 6.826e-10 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-dependent 2.027e-06 Highly Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentNucleus0.0001418Least InformativeDirect
Cellular componentMitochondrion3.005e-07Moderately InformativeDirect
Cellular componentMitochondrion inner membrane2.74e-11InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR007523 SSF64076 Protein matches
Abstract

This is a family of uncharacterised proteins possibly involved in DNA repair.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a MTH938-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the MTH938-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]