SUPERFAMILY 1.75 HMM library and genome assignments server


MTH938-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   MTH938-like [ 64075]
Superfamily:   MTH938-like [ 64076]
Families:   MTH938-like [ 64077] (5)


Superfamily statistics
Genomes (847) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,023 2,112 5
Proteins 1,023 2,112 5


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of metabolic process2.097e-070.03563Least InformativeInherited
Biological Process (BP)regulation of cellular process2.504e-050.3511Least InformativeInherited
Biological Process (BP)positive regulation of metabolic process3.871e-110.0001285Moderately InformativeDirect
Biological Process (BP)regulation of programmed cell death4.25e-124.434e-07Moderately InformativeDirect
Biological Process (BP)regulation of developmental process2.674e-114.597e-05Moderately InformativeDirect
Biological Process (BP)positive regulation of cellular process1.053e-080.003728Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process3.546e-100.002491Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process7.115e-090.001979Moderately InformativeInherited
Biological Process (BP)regulation of biosynthetic process2.841e-100.001961Moderately InformativeInherited
Biological Process (BP)regulation of gene expression3.799e-100.00259Moderately InformativeInherited
Biological Process (BP)regulation of transcription from RNA polymerase II promoter3.396e-145.432e-06InformativeDirect
Biological Process (BP)positive regulation of macromolecule biosynthetic process5.73e-144.371e-06InformativeDirect
Biological Process (BP)positive regulation of gene expression6.166e-143.331e-06InformativeDirect
Biological Process (BP)positive regulation of cellular biosynthetic process1.501e-137.698e-06InformativeDirect
Biological Process (BP)positive regulation of developmental process9.649e-151.896e-08InformativeDirect
Biological Process (BP)positive regulation of nitrogen compound metabolic process1.252e-136.082e-06InformativeDirect
Biological Process (BP)negative regulation of cell death5.008e-143.038e-09InformativeDirect
Biological Process (BP)negative regulation of apoptotic process1.276e-148.534e-10Highly InformativeDirect
Biological Process (BP)positive regulation of transcription, DNA-dependent1.276e-141.859e-06Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of metabolic process 0.03563 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.3511 Least Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.0001285 Moderately Informative Direct
Biological Process (BP) regulation of programmed cell death 4.434e-07 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 4.597e-05 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.003728 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.002491 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.001979 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 0.001961 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.00259 Moderately Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 5.432e-06 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 4.371e-06 Informative Direct
Biological Process (BP) positive regulation of gene expression 3.331e-06 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 7.698e-06 Informative Direct
Biological Process (BP) positive regulation of developmental process 1.896e-08 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 6.082e-06 Informative Direct
Biological Process (BP) negative regulation of cell death 3.038e-09 Informative Direct
Biological Process (BP) negative regulation of apoptotic process 8.534e-10 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-dependent 1.859e-06 Highly Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentNucleus0.0001409Least InformativeDirect
Cellular componentMitochondrion2.988e-07Moderately InformativeDirect
Cellular componentMitochondrion inner membrane2.711e-11InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR007523 SSF64076 Protein matches
Abstract

This is a family of uncharacterised proteins possibly involved in DNA repair.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a MTH938-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the MTH938-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]