SUPERFAMILY 1.75 HMM library and genome assignments server

MoeA N-terminal region -like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   MoeA N-terminal region -like [ 63881]
Superfamily:   MoeA N-terminal region -like [ 63882]
Families:   MoeA N-terminal region -like [ 63883] (2)


Superfamily statistics
Genomes (2,205) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 3,483 16,514 17
Proteins 3,463 16,498 17


Functional annotation
General category Metabolism
Detailed category Coenzyme metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) nitrogen compound metabolic process 0.0001548 Least Informative Direct
Biological Process (BP) biosynthetic process 0.000007687 Least Informative Direct
Biological Process (BP) protein metabolic process 0.000001879 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.00007283 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.000006093 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.002196 Least Informative Inherited
Biological Process (BP) localization 0.09874 Least Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.000000003923 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0.00000000001764 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0.0000000003599 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.0003922 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0.000000000000005526 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0.0000000001003 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 0.000000000001148 Moderately Informative Direct
Biological Process (BP) cellular localization 0.001814 Moderately Informative Inherited
Biological Process (BP) coenzyme biosynthetic process 0.000276 Informative Direct
Biological Process (BP) molybdopterin cofactor metabolic process 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Nucleotidyltransferases0.00002377Least InformativeDirect
Enzyme Commission (EC)Transferring molybdenum- or tungsten-containing gr0Highly InformativeDirect
Enzyme Commission (EC)Molybdopterin adenylyltransferase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0.8418Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0.00002494Moderately InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processMolybdenum cofactor biosynthesis0Highly InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCytoskeleton0.0000007113Moderately InformativeDirect
Molecular functionMetal-binding0.0000000000005576Least InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Molecular functionMolybdenum0InformativeDirect
Post-translational modificationTransferase0.00000000000001219Least InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)cofactor metabolism0Least InformativeDirect
UniPathway (UP)molybdopterin biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR005110 SSF63882 Protein matches
Abstract

Proteins in this family contain two structural domains. One of these contains the conserved DGXA motif. This region is found in proteins involved in biosynthesis of molybdopterin cofactor however the exact molecular function of this region is uncertain.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a MoeA N-terminal region -like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the MoeA N-terminal region -like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]