SUPERFAMILY 1.75 HMM library and genome assignments server


MoeA C-terminal domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   beta-clip [ 51268] (7)
Superfamily:   MoeA C-terminal domain-like [ 63867]
Families:   MoeA C-terminal domain-like [ 63868] (2)


Superfamily statistics
Genomes (2,120) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 3,200 15,036 17
Proteins 3,198 15,035 17


Functional annotation
General category Metabolism
Detailed category Coenzyme metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biosynthetic process 1.779e-07 Least Informative Direct
Biological Process (BP) protein metabolic process 2.852e-07 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 3.327e-07 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 9.927e-07 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 3.196e-06 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 2.127e-05 Least Informative Direct
Biological Process (BP) localization 0.01109 Least Informative Inherited
Biological Process (BP) developmental process 0.06141 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.1018 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.0568 Least Informative Inherited
Biological Process (BP) cofactor metabolic process 0 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 4.131e-14 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 6.643e-13 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 1.384e-12 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 4.756e-12 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 3.396e-09 Moderately Informative Direct
Biological Process (BP) macromolecule localization 5.195e-06 Moderately Informative Direct
Biological Process (BP) cellular localization 3.567e-05 Moderately Informative Direct
Biological Process (BP) cellular component biogenesis 0.0002577 Moderately Informative Direct
Biological Process (BP) nervous system development 0.0007551 Moderately Informative Direct
Biological Process (BP) cellular membrane organization 8.632e-07 Informative Direct
Biological Process (BP) coenzyme biosynthetic process 7.078e-05 Informative Direct
Biological Process (BP) molybdopterin cofactor metabolic process 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Nucleotidyltransferases2.377e-05Least InformativeDirect
Enzyme Commission (EC)Transferring molybdenum- or tungsten-containing gr0Highly InformativeDirect
Enzyme Commission (EC)Molybdopterin adenylyltransferase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0.8442Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases2.533e-05Moderately InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processMolybdenum cofactor biosynthesis0Highly InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCytoskeleton7.025e-07Moderately InformativeDirect
Molecular functionMetal-binding4.519e-13Least InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Molecular functionMolybdenum0InformativeDirect
Post-translational modificationTransferase1.218e-14Least InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)cofactor metabolism0Least InformativeDirect
UniPathway (UP)molybdopterin biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR005111 SSF63867 Protein matches
Abstract

This domain is found in proteins involved in biosynthesis of molybdopterin cofactor however the exact molecular function of this domain is uncertain. The structure of this domain is known [PubMed11525167] and forms an incomplete beta barrel.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a MoeA C-terminal domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the MoeA C-terminal domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]