SUPERFAMILY 1.75 HMM library and genome assignments server

MoeA C-terminal domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   beta-clip [ 51268] (7)
Superfamily:   MoeA C-terminal domain-like [ 63867]
Families:   MoeA C-terminal domain-like [ 63868] (2)


Superfamily statistics
Genomes (2,120) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 3,199 15,036 17
Proteins 3,197 15,035 17


Functional annotation
General category Metabolism
Detailed category Coenzyme metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0.0000003737 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.000001356 Least Informative Direct
Biological Process (BP) biosynthetic process 0.000002745 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.00003163 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.00007162 Least Informative Direct
Biological Process (BP) developmental process 0.06503 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.001276 Least Informative Inherited
Biological Process (BP) localization 0.01381 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.02421 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.08963 Least Informative Inherited
Biological Process (BP) cofactor metabolic process 0 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 0.0000000000000615 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0.000000000001208 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0.000000000008091 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0.00000000005451 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0.0000000005165 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.000005263 Moderately Informative Direct
Biological Process (BP) cellular localization 0.00004423 Moderately Informative Direct
Biological Process (BP) nervous system development 0.0008286 Moderately Informative Direct
Biological Process (BP) cellular component biogenesis 0.001803 Moderately Informative Inherited
Biological Process (BP) single-organism membrane organization 0.0000001142 Informative Direct
Biological Process (BP) single-organism cellular localization 0.00003001 Informative Direct
Biological Process (BP) coenzyme biosynthetic process 0.000126 Informative Direct
Biological Process (BP) molybdopterin cofactor metabolic process 0 Highly Informative Direct
Biological Process (BP) protein localization to membrane 0.00006478 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Nucleotidyltransferases0.00002377Least InformativeDirect
Enzyme Commission (EC)Transferring molybdenum- or tungsten-containing gr0Highly InformativeDirect
Enzyme Commission (EC)Molybdopterin adenylyltransferase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0.8418Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0.00002494Moderately InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processMolybdenum cofactor biosynthesis0Highly InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCytoskeleton0.0000007113Moderately InformativeDirect
Molecular functionMetal-binding0.0000000000005576Least InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Molecular functionMolybdenum0InformativeDirect
Post-translational modificationTransferase0.00000000000001219Least InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)cofactor metabolism0Least InformativeDirect
UniPathway (UP)molybdopterin biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR005111 SSF63867 Protein matches
Abstract

This domain is found in proteins involved in biosynthesis of molybdopterin cofactor however the exact molecular function of this domain is uncertain. The structure of this domain is known [PubMed11525167] and forms an incomplete beta barrel.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a MoeA C-terminal domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the MoeA C-terminal domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]