SUPERFAMILY 1.75 HMM library and genome assignments server

Thiamin pyrophosphokinase, substrate-binding domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Double-stranded beta-helix [ 51181] (7)
Superfamily:   Thiamin pyrophosphokinase, substrate-binding domain [ 63862]
Families:   Thiamin pyrophosphokinase, substrate-binding domain [ 63863]


Superfamily statistics
Genomes (972) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,113 6,111 2
Proteins 1,113 6,111 2


Functional annotation
General category Metabolism
Detailed category Coenzyme metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0.00006802 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.0002136 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.00006054 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.0001104 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.1821 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.006889 Least Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.0000000001055 Moderately Informative Direct
Biological Process (BP) vitamin metabolic process 0.00000000000824 Informative Direct
Biological Process (BP) pyrimidine-containing compound metabolic process 0.00000000000001587 Informative Direct
Biological Process (BP) thiamine-containing compound metabolic process 0 Highly Informative Direct
Molecular Function (MF) transferase activity 0.00000001347 Least Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.00000000003275 Moderately Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Diphosphotransferases0InformativeDirect

Document: EC annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Diphosphotransferases0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Coding sequence diversityAlternative splicing0.00005293Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)cofactor metabolism0Least InformativeDirect
UniPathway (UP)thiamine metabolism0InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Thiamin pyrophosphokinase, substrate-binding domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Thiamin pyrophosphokinase, substrate-binding domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]