SUPERFAMILY 1.75 HMM library and genome assignments server


Calcium-dependent phosphotriesterase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   6-bladed beta-propeller [ 50938] (11)
Superfamily:   Calcium-dependent phosphotriesterase [ 63829] (3)
Families:   SGL-like [ 63830] (3)
  Serum paraoxonase/arylesterase 1, PON1 [ 101895]
  All0351-like [ 159252]


Superfamily statistics
Genomes (1,925) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 11,728 38,162 6
Proteins 10,372 32,361 6


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism cellular process0.88661Least InformativeInherited
Biological Process (BP)biosynthetic process0.29470.4097Least InformativeInherited
Biological Process (BP)regulation of cellular process0.05611Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.0075461Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.0066740.1216Least InformativeInherited
Biological Process (BP)regulation of signal transduction1.321e-050.189Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process10.01095Moderately InformativeInherited
Biological Process (BP)regulation of catalytic activity5.519e-050.02567Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.0052260.6874Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function3.587e-080.001494Moderately InformativeInherited
Biological Process (BP)single-organism biosynthetic process0.0015611.355e-05Moderately InformativeInherited
Biological Process (BP)carbohydrate metabolic process2.136e-050.0116Moderately InformativeInherited
Biological Process (BP)homeostatic process0.0011330.04917Moderately InformativeInherited
Biological Process (BP)vitamin metabolic process8.642e-082.416e-07InformativeDirect
Biological Process (BP)regulation of nucleoside metabolic process1.566e-126.485e-06InformativeDirect
Biological Process (BP)carbohydrate biosynthetic process6.137e-098.039e-06InformativeDirect
Biological Process (BP)cellular cation homeostasis6.13e-116.028e-06InformativeDirect
Biological Process (BP)regulation of cellular catabolic process2.408e-080.0002822InformativeDirect
Biological Process (BP)metal ion homeostasis1.313e-114.725e-06InformativeDirect
Biological Process (BP)regulation of purine nucleotide metabolic process2.31e-113.621e-05InformativeDirect
Biological Process (BP)positive regulation of hydrolase activity5.928e-110.002634InformativeInherited
Biological Process (BP)cellular calcium ion homeostasis3.321e-151.578e-08Highly InformativeDirect
Biological Process (BP)monosaccharide biosynthetic process2.86e-072.189e-07Highly InformativeDirect
Biological Process (BP)regulation of calcium-mediated signaling01.944e-15Highly InformativeDirect
Molecular Function (MF)hydrolase activity6.958e-090.0001023Least InformativeDirect
Molecular Function (MF)binding0.21811Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds08.184e-07Moderately InformativeDirect
Molecular Function (MF)cation binding2.648e-123.962e-05Moderately InformativeDirect
Molecular Function (MF)transition metal ion binding0.098830.1818InformativeInherited
Molecular Function (MF)calcium ion binding00Highly InformativeDirect
Molecular Function (MF)carboxylic ester hydrolase activity00Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.4097 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.1216 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism biosynthetic process 1.355e-05 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.189 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.01095 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.02567 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.6874 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.001494 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.0116 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.04917 Moderately Informative Inherited
Biological Process (BP) vitamin metabolic process 2.416e-07 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 6.485e-06 Informative Direct
Biological Process (BP) carbohydrate biosynthetic process 8.039e-06 Informative Direct
Biological Process (BP) cellular cation homeostasis 6.028e-06 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0.0002822 Informative Direct
Biological Process (BP) metal ion homeostasis 4.725e-06 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 3.621e-05 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.002634 Informative Inherited
Biological Process (BP) cellular amide metabolic process 0.002505 Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 1.578e-08 Highly Informative Direct
Biological Process (BP) monosaccharide biosynthetic process 2.189e-07 Highly Informative Direct
Biological Process (BP) regulation of calcium-mediated signaling 1.944e-15 Highly Informative Direct
Molecular Function (MF) hydrolase activity 0.0001023 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 8.184e-07 Moderately Informative Direct
Molecular Function (MF) lyase activity 1.781e-07 Moderately Informative Direct
Molecular Function (MF) cation binding 3.962e-05 Moderately Informative Direct
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) transition metal ion binding 0.1818 Informative Inherited
Molecular Function (MF) peptidase activity 0.2136 Informative Inherited
Molecular Function (MF) endopeptidase activity 1.404e-06 Highly Informative Direct
Molecular Function (MF) monooxygenase activity 0.0001166 Highly Informative Direct
Molecular Function (MF) calcium ion binding 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0.0006737 Highly Informative Direct
Molecular Function (MF) serine hydrolase activity 1.192e-05 Highly Informative Direct
Molecular Function (MF) carboxylic ester hydrolase activity 0 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.924 Least Informative Inherited
Cellular Component (CC) cell surface 1.101e-05 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Lyases0.00446Least InformativeInherited
Enzyme Commission (EC)Carboxylic ester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Carbon-nitrogen lyases6.457e-14InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.04729Least InformativeInherited
Mammalian Phenotype (MP)oxidative stress9.401e-06Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases3.438e-14Least InformativeDirect
Enzyme Commission (EC)Lyases0.006472Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.9502Least InformativeInherited
Enzyme Commission (EC)Carboxylic ester hydrolases0InformativeDirect
Enzyme Commission (EC)Carbon-nitrogen lyases2.773e-12InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen0.0006643InformativeDirect
Enzyme Commission (EC)Lyases acting on amides, amidines, etc0.3736Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAntibiotic resistance0InformativeDirect
Cellular componentCytoplasmic vesicle3.598e-05Moderately InformativeDirect
Cellular componentVacuole6.273e-08InformativeDirect
DomainSignal7.437e-08Least InformativeDirect
DomainTransmembrane0.8058Least InformativeInherited
DomainEGF-like domain1.932e-05InformativeDirect
DomainSignal-anchor9.909e-05InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Post-translational modificationHydrolase1.987e-14Least InformativeDirect
Post-translational modificationLyase8.471e-10Moderately InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)carbohydrate metabolism2.103e-06Least InformativeDirect
UniPathway (UP)cofactor metabolism0.0001511Least InformativeDirect
UniPathway (UP)carbohydrate biosynthesis0Moderately InformativeDirect
UniPathway (UP)secondary metabolite metabolism8.087e-09Moderately InformativeDirect
UniPathway (UP)nitrogen metabolism3.431e-08Moderately InformativeDirect
UniPathway (UP)alkaloid metabolism1.564e-15InformativeDirect
UniPathway (UP)terpene metabolism2.864e-11InformativeDirect
UniPathway (UP)L-ascorbate biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Calcium-dependent phosphotriesterase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the Calcium-dependent phosphotriesterase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]