SUPERFAMILY 1.75 HMM library and genome assignments server

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Calcium-dependent phosphotriesterase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   6-bladed beta-propeller [ 50938] (11)
Superfamily:   Calcium-dependent phosphotriesterase [ 63829] (3)
Families:   SGL-like [ 63830] (3)
  Serum paraoxonase/arylesterase 1, PON1 [ 101895]
  All0351-like [ 159252]


Superfamily statistics
Genomes (1,925) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 11,731 38,162 6
Proteins 10,375 32,361 6


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism cellular process0.88021Least InformativeInherited
Biological Process (BP)biosynthetic process0.30480.4502Least InformativeInherited
Biological Process (BP)regulation of cellular process0.060671Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.0083411Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.0088490.1482Least InformativeInherited
Biological Process (BP)regulation of biological quality0.000060110.09454Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.000014290.2027Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process10.01259Moderately InformativeInherited
Biological Process (BP)regulation of catalytic activity0.000053730.02933Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.0055410.7097Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function0.00000004050.001806Moderately InformativeInherited
Biological Process (BP)single-organism biosynthetic process0.0017030.00001955Moderately InformativeInherited
Biological Process (BP)carbohydrate metabolic process0.000025920.01286Moderately InformativeInherited
Biological Process (BP)vitamin metabolic process0.000000083480.0000002473InformativeDirect
Biological Process (BP)regulation of nucleoside metabolic process0.0000000000021810.000008953InformativeDirect
Biological Process (BP)carbohydrate biosynthetic process0.0000000074150.000009478InformativeDirect
Biological Process (BP)regulation of cellular catabolic process0.000000027520.0003562InformativeDirect
Biological Process (BP)cation homeostasis0.00000000033070.00003835InformativeDirect
Biological Process (BP)cellular chemical homeostasis0.00000000032150.00002605InformativeDirect
Biological Process (BP)regulation of purine nucleotide metabolic process0.000000000030050.00004725InformativeDirect
Biological Process (BP)positive regulation of hydrolase activity0.000000000073390.002848InformativeInherited
Biological Process (BP)cellular calcium ion homeostasis0.0000000000000032580.00000001768Highly InformativeDirect
Biological Process (BP)monosaccharide biosynthetic process0.00000029080.000000215Highly InformativeDirect
Biological Process (BP)regulation of calcium-mediated signaling00.000000000000001931Highly InformativeDirect
Molecular Function (MF)hydrolase activity0.0000000098560.00009592Least InformativeDirect
Molecular Function (MF)binding0.2461Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds00.000001056Moderately InformativeDirect
Molecular Function (MF)cation binding0.000000000005870.00004695Moderately InformativeDirect
Molecular Function (MF)zinc ion binding0.00000000000013190.0000000002615InformativeDirect
Molecular Function (MF)calcium ion binding00Highly InformativeDirect
Molecular Function (MF)carboxylic ester hydrolase activity00Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.4502 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.1482 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism biosynthetic process 0.00001955 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.09454 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.2027 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.01259 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.02933 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.7097 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.001806 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.01286 Moderately Informative Inherited
Biological Process (BP) peptide metabolic process 0.0002535 Informative Direct
Biological Process (BP) vitamin metabolic process 0.0000002473 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 0.000008953 Informative Direct
Biological Process (BP) carbohydrate biosynthetic process 0.000009478 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0.0003562 Informative Direct
Biological Process (BP) cation homeostasis 0.00003835 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0.00002605 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0.00004725 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.002848 Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 0.00000001768 Highly Informative Direct
Biological Process (BP) monosaccharide biosynthetic process 0.000000215 Highly Informative Direct
Biological Process (BP) regulation of calcium-mediated signaling 0.000000000000001931 Highly Informative Direct
Molecular Function (MF) hydrolase activity 0.00009592 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.000001056 Moderately Informative Direct
Molecular Function (MF) lyase activity 0.0000002058 Moderately Informative Direct
Molecular Function (MF) cation binding 0.00004695 Moderately Informative Direct
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) zinc ion binding 0.0000000002615 Informative Direct
Molecular Function (MF) peptidase activity 0.2088 Informative Inherited
Molecular Function (MF) endopeptidase activity 0.000001509 Highly Informative Direct
Molecular Function (MF) monooxygenase activity 0.0001406 Highly Informative Direct
Molecular Function (MF) calcium ion binding 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0.000766 Highly Informative Direct
Molecular Function (MF) serine hydrolase activity 0.00001141 Highly Informative Direct
Molecular Function (MF) carboxylic ester hydrolase activity 0 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.9455 Least Informative Inherited
Cellular Component (CC) cell surface 0.0000107 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Lyases0.00446Least InformativeInherited
Enzyme Commission (EC)Carboxylic ester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Carbon-nitrogen lyases0.00000000000006457InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.04875Least InformativeInherited
Mammalian Phenotype (MP)oxidative stress0.000009353Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.00000000000003901Least InformativeDirect
Enzyme Commission (EC)Lyases0.006668Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.9483Least InformativeInherited
Enzyme Commission (EC)Carboxylic ester hydrolases0InformativeDirect
Enzyme Commission (EC)Carbon-nitrogen lyases0.000000000002848InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen0.0006677InformativeDirect
Enzyme Commission (EC)Lyases acting on amides, amidines, etc0.3699Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAntibiotic resistance0InformativeDirect
Cellular componentCytoplasmic vesicle0.00003598Moderately InformativeDirect
Cellular componentVacuole0.00000006273InformativeDirect
DomainSignal0.00000007437Least InformativeDirect
DomainTransmembrane0.8058Least InformativeInherited
DomainEGF-like domain0.00001932InformativeDirect
DomainSignal-anchor0.00009909InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Post-translational modificationHydrolase0.00000000000001987Least InformativeDirect
Post-translational modificationLyase0.0000000008471Moderately InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Calcium-dependent phosphotriesterase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the Calcium-dependent phosphotriesterase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]