SUPERFAMILY 1.75 HMM library and genome assignments server


Leukotriene A4 hydrolase N-terminal domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Leukotriene A4 hydrolase N-terminal domain [ 63736]
Superfamily:   Leukotriene A4 hydrolase N-terminal domain [ 63737]
Families:   Leukotriene A4 hydrolase N-terminal domain [ 63738]


Superfamily statistics
Genomes (2,052) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 6,596 16,255 7
Proteins 6,482 16,174 7


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) nitrogen compound metabolic process 0.000004183 Least Informative Direct
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) localization 0.7101 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.00297 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.633 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) cellular catabolic process 0 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0 Moderately Informative Direct
Biological Process (BP) system process 0.0001269 Moderately Informative Direct
Biological Process (BP) lipid biosynthetic process 0.0006491 Moderately Informative Direct
Biological Process (BP) immune system process 0.8442 Moderately Informative Inherited
Biological Process (BP) single-organism biosynthetic process 0.01583 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.002264 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 0.09155 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) cellular amide metabolic process 0 Informative Direct
Biological Process (BP) blood circulation 0 Informative Direct
Biological Process (BP) proteolysis 0.00000008257 Informative Direct
Biological Process (BP) monocarboxylic acid biosynthetic process 0.000002455 Informative Direct
Biological Process (BP) fatty acid metabolic process 0.00001073 Informative Direct
Biological Process (BP) localization of cell 0.00003664 Informative Direct
Biological Process (BP) locomotion 0.003677 Informative Inherited
Biological Process (BP) cellular component movement 0.004352 Informative Inherited
Biological Process (BP) cardiovascular system development 0.1392 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.4065 Informative Inherited
Biological Process (BP) regulation of blood pressure 0 Highly Informative Direct
Biological Process (BP) fatty acid derivative biosynthetic process 0.00000000000004241 Highly Informative Direct
Biological Process (BP) icosanoid metabolic process 0.000000000009567 Highly Informative Direct
Biological Process (BP) unsaturated fatty acid metabolic process 0.00000000008052 Highly Informative Direct
Biological Process (BP) antigen processing and presentation 0.00007307 Highly Informative Direct
Biological Process (BP) angiogenesis 0.0004922 Highly Informative Direct
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.01827 Least Informative Inherited
Molecular Function (MF) cation binding 0.0000000000003734 Moderately Informative Direct
Molecular Function (MF) peptidase activity 0 Informative Direct
Molecular Function (MF) transition metal ion binding 0 Informative Direct
Molecular Function (MF) amide binding 0.0007412 Informative Direct
Molecular Function (MF) exopeptidase activity 0 Highly Informative Direct
Molecular Function (MF) metallopeptidase activity 0.0003962 Highly Informative Direct
Cellular Component (CC) membrane 0.0008611 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.0407 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.03243 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) organelle membrane 0.0000005439 Moderately Informative Direct
Cellular Component (CC) vesicle 0.00001591 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.02816 Moderately Informative Inherited
Cellular Component (CC) vacuolar part 0.000000000000003132 Informative Direct
Cellular Component (CC) lytic vacuole 0.000000000000003132 Informative Direct
Cellular Component (CC) cell surface 0.001706 Informative Inherited
Cellular Component (CC) lysosome 0 Highly Informative Direct
Cellular Component (CC) external side of plasma membrane 0.00004505 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.0000000000002536Least InformativeDirect
Enzyme Commission (EC)Aminopeptidases0InformativeDirect
Enzyme Commission (EC)Acting on ether bonds0InformativeDirect
Enzyme Commission (EC)Leukotriene-A(4) hydrolase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)artery disease0.0004882Moderately InformativeDirect
Disease Ontology (DO)hypertension0.00006547InformativeDirect

Document: DO annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)pericellular component development variant0.00007564Moderately InformativeDirect
Worm Phenotype (WP)basement membrane remodeling variant0.00003139InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)fertile0Moderately InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Omega peptidases0.9066InformativeInherited
Enzyme Commission (EC)Acting on ether bonds0Highly InformativeDirect
Enzyme Commission (EC)Aminopeptidases0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0.000004926Moderately InformativeDirect
Biological processAngiogenesis0.000000000006847InformativeDirect
Biological processAdaptive immunity0.00000000004191Highly InformativeDirect
Cellular componentNucleus0.0000000003427Least InformativeDirect
Cellular componentEndoplasmic reticulum0.000009313Moderately InformativeDirect
DomainTransmembrane0.000002356Least InformativeDirect
DomainSignal-anchor0InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationMetalloprotease0InformativeDirect
Post-translational modificationAminopeptidase0Highly InformativeDirect
Post-translational modificationGlycoprotein0.00000000637Least InformativeDirect
Post-translational modificationSulfation0.00000000003512InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)lipid metabolism0Least InformativeDirect
UniPathway (UP)fatty acid metabolism0Moderately InformativeDirect
UniPathway (UP)leukotriene biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Leukotriene A4 hydrolase N-terminal domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Leukotriene A4 hydrolase N-terminal domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]