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LuxS/MPP-like metallohydrolase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   LuxS/MPP-like metallohydrolase [ 63410]
Superfamily:   LuxS/MPP-like metallohydrolase [ 63411] (2)
Families:   Autoinducer-2 production protein LuxS [ 64294]
  MPP-like [ 63412] (6)


Superfamily statistics
Genomes (2,850) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 28,837 118,763 44
Proteins 11,841 54,569 23


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Cellular Component (CC)cytoplasmic part0.0053360Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.086030.03217Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.0054660Least InformativeInherited
Cellular Component (CC)membrane0.030970.181Least InformativeInherited
Cellular Component (CC)mitochondrial part0.00079650Moderately InformativeDirect
Cellular Component (CC)organelle envelope0.0012170.0000000001872Moderately InformativeInherited
Cellular Component (CC)organelle membrane0.002220.000001659Moderately InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0.0000000002395 Least Informative Direct
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.7315 Least Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.1399 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.1703 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.4437 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.09632 Moderately Informative Inherited
Biological Process (BP) gene expression 0.6647 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.2064 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.05939 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.04985 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.3252 Moderately Informative Inherited
Biological Process (BP) proteolysis 0.00000000003415 Informative Direct
Biological Process (BP) mitochondrion organization 0.000003192 Informative Direct
Biological Process (BP) protein localization to organelle 0.00002418 Informative Direct
Biological Process (BP) cytoplasmic transport 0.0002022 Informative Direct
Biological Process (BP) protein transport 0.0006878 Informative Direct
Biological Process (BP) energy derivation by oxidation of organic compounds 0.000708 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.006116 Informative Inherited
Biological Process (BP) response to lipid 0.0444 Informative Inherited
Biological Process (BP) phosphorylation 0.007619 Informative Inherited
Biological Process (BP) protein localization to mitochondrion 0.000000000002338 Highly Informative Direct
Biological Process (BP) oxidative phosphorylation 0.00000000003711 Highly Informative Direct
Biological Process (BP) mitochondrial transport 0.0000000007911 Highly Informative Direct
Biological Process (BP) establishment of protein localization to organelle 0.00000004823 Highly Informative Direct
Biological Process (BP) electron transport chain 0.000003057 Highly Informative Direct
Biological Process (BP) response to alcohol 0.004388 Highly Informative Inherited
Biological Process (BP) protein processing 0.5276 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0.000000001141 Least Informative Direct
Molecular Function (MF) binding 0.9143 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0.3416 Moderately Informative Inherited
Molecular Function (MF) transporter activity 0.02453 Moderately Informative Inherited
Molecular Function (MF) cation binding 0.03892 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.2143 Moderately Informative Inherited
Molecular Function (MF) peptidase activity 0 Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 0.00004197 Informative Direct
Molecular Function (MF) zinc ion binding 0.00006647 Informative Direct
Molecular Function (MF) nucleotide binding 0.02563 Informative Inherited
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.003944 Informative Inherited
Molecular Function (MF) purine ribonucleoside binding 0.005106 Informative Inherited
Molecular Function (MF) endopeptidase activity 0 Highly Informative Direct
Molecular Function (MF) metallopeptidase activity 0 Highly Informative Direct
Molecular Function (MF) hydrogen ion transmembrane transporter activity 0.000000001105 Highly Informative Direct
Molecular Function (MF) ATP binding 0.0005798 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.03217 Least Informative Inherited
Cellular Component (CC) protein complex 0.0608 Least Informative Inherited
Cellular Component (CC) membrane 0.181 Least Informative Inherited
Cellular Component (CC) mitochondrial part 0 Moderately Informative Direct
Cellular Component (CC) organelle envelope 0.0000000001872 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.000001659 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0.8271 Moderately Informative Inherited
Cellular Component (CC) respiratory chain 0.00000000002576 Informative Direct
Cellular Component (CC) mitochondrial matrix 0.00000004655 Informative Direct
Cellular Component (CC) mitochondrial membrane part 0.0000008839 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0InformativeDirect
Enzyme Commission (EC)Carbon-sulfur lyases1Highly InformativeInherited

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)pericellular component development variant0.0000293Moderately InformativeDirect
Worm Phenotype (WP)basement membrane remodeling variant0.00001202InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)alimentary system0Least InformativeDirect
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)cell0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)ectoderm0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)intestine0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)ovary0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)gamete0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)heart0InformativeDirect
Xenopus ANatomical entity (XAN)anatomical entity in vitro0InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)portion of meristem tissue0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence meristem0Moderately InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0InformativeDirect
Enzyme Commission (EC)Carbon-sulfur lyases1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.9421Least InformativeInherited
Biological processElectron transport0.0000000002705InformativeDirect
Biological processRespiratory chain0Highly InformativeDirect
Cellular componentMitochondrion0Moderately InformativeDirect
Cellular componentPeriplasm0.00002246InformativeDirect
DomainTransit peptide0Moderately InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionIron0Moderately InformativeDirect
Post-translational modificationHydrolase0.0000000000007871Least InformativeDirect
Post-translational modificationLyase0Moderately InformativeDirect
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationMetalloprotease0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR011249 SSF63411 Protein matches
Abstract

This entry represents domains with a two-layer alpha/beta structure found in metalloenzymes such as LuxS (S-ribosylhomocysteinase) and metallopeptidases belonging to MEROPS peptidase family M16. These domains share the same active site motif of HxxEH located in the first core helix, but differ in one of the metal-binding residues. LuxS, the AI-2 (autoinducer-2) producing enzyme for quorum sensing in bacteria, is a homodimeric iron-dependent metalloenzyme containing two identical tetrahedral metal-binding sites similar to those found in peptidases and amidases, although it contains an extra N-terminal strand [PubMed15751951, PubMed11553770]. Some M16 family metallopeptidases, such as mitochondrial processing peptidase (MPP), share the same common fold elaborated with many extra additional structures [PubMed11470436]. These peptidases usually contain a duplication of this domain, although only the N-terminal domain binds the catalytic metal.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 28 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a LuxS/MPP-like metallohydrolase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 28 hidden Markov models representing the LuxS/MPP-like metallohydrolase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]