Riboflavin synthase domain-like superfamily

SCOP classification

Root:	SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:	All beta proteins [ 48724] (174)
Fold:	Reductase/isomerase/elongation factor common domain [ 50412] (4)
Superfamily:	Riboflavin synthase domain-like [ 63380] (3)
Families:	Riboflavin synthase [ 63783]
	Ferredoxin reductase FAD-binding domain-like [ 63381] (9)
	NADPH-cytochrome p450 reductase FAD-binding domain-like [ 50438] (3)

Superfamily statistics

	Genomes (2,320)	Uniprot 2013_05	PDB chains (SCOP 1.75)
Domains	20,891	51,774	62
Proteins	18,858	45,340	60

Functional annotation

General category	Metabolism
Detailed category	Coenzyme metabolism and transport

Document: Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)

	GO term	FDR (singleton)	FDR (all)	SDFO level	Annotation (direct or inherited)
Cellular Component (CC)	cytoplasmic part	1.728e-05	3.115e-06	Least Informative	Direct
Cellular Component (CC)	intracellular membrane-bounded organelle	1.678e-05	0.09342	Least Informative	Inherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)

	GO term	FDR (all)	SDFO level	Annotation (direct or inherited)
Biological Process (BP)	response to stimulus	1.353e-08	Least Informative	Direct
Biological Process (BP)	single-organism metabolic process	6.596e-05	Least Informative	Direct
Biological Process (BP)	regulation of metabolic process	1	Least Informative	Inherited
Biological Process (BP)	biosynthetic process	0.7002	Least Informative	Inherited
Biological Process (BP)	organic cyclic compound metabolic process	0.1422	Least Informative	Inherited
Biological Process (BP)	cellular aromatic compound metabolic process	1	Least Informative	Inherited
Biological Process (BP)	multicellular organismal process	0.6487	Least Informative	Inherited
Biological Process (BP)	regulation of cellular process	1	Least Informative	Inherited
Biological Process (BP)	protein metabolic process	1	Least Informative	Inherited
Biological Process (BP)	cellular macromolecule metabolic process	1	Least Informative	Inherited
Biological Process (BP)	heterocycle metabolic process	1	Least Informative	Inherited
Biological Process (BP)	nitrogen compound metabolic process	1	Least Informative	Inherited
Biological Process (BP)	developmental process	0.2713	Least Informative	Inherited
Biological Process (BP)	single-organism cellular process	1	Least Informative	Inherited
Biological Process (BP)	localization	0.644	Least Informative	Inherited
Biological Process (BP)	oxidation-reduction process	2.097e-12	Moderately Informative	Direct
Biological Process (BP)	multi-organism process	6.828e-11	Moderately Informative	Direct
Biological Process (BP)	cellular response to chemical stimulus	8.707e-08	Moderately Informative	Direct
Biological Process (BP)	organic hydroxy compound metabolic process	2.838e-06	Moderately Informative	Direct
Biological Process (BP)	response to oxygen-containing compound	2.857e-05	Moderately Informative	Direct
Biological Process (BP)	cellular nitrogen compound biosynthetic process	6.455e-05	Moderately Informative	Direct
Biological Process (BP)	regulation of cellular metabolic process	1	Moderately Informative	Inherited
Biological Process (BP)	regulation of molecular function	0.411	Moderately Informative	Inherited
Biological Process (BP)	regulation of localization	0.1983	Moderately Informative	Inherited
Biological Process (BP)	single-organism developmental process	0.05799	Moderately Informative	Inherited
Biological Process (BP)	homeostatic process	0.1216	Moderately Informative	Inherited
Biological Process (BP)	response to organic substance	0.6132	Moderately Informative	Inherited
Biological Process (BP)	signal transduction	0.3906	Moderately Informative	Inherited
Biological Process (BP)	cellular protein modification process	0.632	Moderately Informative	Inherited
Biological Process (BP)	response to endogenous stimulus	0.04072	Moderately Informative	Inherited
Biological Process (BP)	cellular response to stress	1	Moderately Informative	Inherited
Biological Process (BP)	organic cyclic compound biosynthetic process	0.06475	Moderately Informative	Inherited
Biological Process (BP)	organonitrogen compound biosynthetic process	0.3509	Moderately Informative	Inherited
Biological Process (BP)	heterocycle biosynthetic process	1	Moderately Informative	Inherited
Biological Process (BP)	small molecule biosynthetic process	0.07014	Moderately Informative	Inherited
Biological Process (BP)	organic substance catabolic process	0.1959	Moderately Informative	Inherited
Biological Process (BP)	cellular catabolic process	0.7959	Moderately Informative	Inherited
Biological Process (BP)	cellular amino acid metabolic process	0.002693	Moderately Informative	Inherited
Biological Process (BP)	system process	0.6767	Moderately Informative	Inherited
Biological Process (BP)	ion transport	0.1896	Moderately Informative	Inherited
Biological Process (BP)	response to cytokine stimulus	0.0001047	Informative	Direct
Biological Process (BP)	response to organic nitrogen	0.0001623	Informative	Direct
Biological Process (BP)	vitamin metabolic process	0.000289	Informative	Direct
Biological Process (BP)	peptidyl-amino acid modification	0.0002946	Informative	Direct
Biological Process (BP)	organic hydroxy compound biosynthetic process	0.0003479	Informative	Direct
Biological Process (BP)	regulation of ion transport	0.00039	Informative	Direct
Biological Process (BP)	response to organic cyclic compound	0.0004869	Informative	Direct
Biological Process (BP)	blood circulation	0.0005784	Informative	Direct
Biological Process (BP)	cellular response to oxygen-containing compound	0.2199	Informative	Inherited
Biological Process (BP)	negative regulation of molecular function	0.09302	Informative	Inherited
Biological Process (BP)	regulation of hydrolase activity	0.4004	Informative	Inherited
Biological Process (BP)	cellular cation homeostasis	0.00796	Informative	Inherited
Biological Process (BP)	metal ion homeostasis	0.2541	Informative	Inherited
Biological Process (BP)	steroid metabolic process	0.003844	Informative	Inherited
Biological Process (BP)	alcohol metabolic process	0.3918	Informative	Inherited
Biological Process (BP)	response to external stimulus	0.8921	Informative	Inherited
Biological Process (BP)	carboxylic acid catabolic process	0.08439	Informative	Inherited
Biological Process (BP)	organonitrogen compound catabolic process	0.57	Informative	Inherited
Biological Process (BP)	metal ion transport	0.2977	Informative	Inherited
Biological Process (BP)	glutamine family amino acid metabolic process	0.001701	Informative	Inherited
Biological Process (BP)	response to purine-containing compound	6.795e-13	Highly Informative	Direct
Biological Process (BP)	cytokine-mediated signaling pathway	4.019e-10	Highly Informative	Direct
Biological Process (BP)	glutamine family amino acid catabolic process	2.013e-08	Highly Informative	Direct
Biological Process (BP)	arginine metabolic process	1.127e-06	Highly Informative	Direct
Biological Process (BP)	cellular iron ion homeostasis	9.845e-06	Highly Informative	Direct
Biological Process (BP)	regulation of calcium ion transport	2.036e-05	Highly Informative	Direct
Biological Process (BP)	superoxide metabolic process	3.665e-05	Highly Informative	Direct
Biological Process (BP)	benzene-containing compound metabolic process	7.019e-05	Highly Informative	Direct
Biological Process (BP)	sterol metabolic process	0.0001218	Highly Informative	Direct
Biological Process (BP)	phenol-containing compound metabolic process	0.0001384	Highly Informative	Direct
Biological Process (BP)	symbiosis, encompassing mutualism through parasitism	0.0003922	Highly Informative	Direct
Biological Process (BP)	transition metal ion transport	0.0004566	Highly Informative	Direct
Biological Process (BP)	hydrogen peroxide metabolic process	1	Highly Informative	Inherited
Biological Process (BP)	cellular response to starvation	0.05937	Highly Informative	Inherited
Biological Process (BP)	aging	0.01307	Highly Informative	Inherited
Biological Process (BP)	multi-organism behavior	0.01805	Highly Informative	Inherited
Molecular Function (MF)	binding	0.8652	Least Informative	Inherited
Molecular Function (MF)	transferase activity	1	Least Informative	Inherited
Molecular Function (MF)	oxidoreductase activity	0	Moderately Informative	Direct
Molecular Function (MF)	heterocyclic compound binding	8.824e-06	Moderately Informative	Direct
Molecular Function (MF)	organic cyclic compound binding	1.365e-05	Moderately Informative	Direct
Molecular Function (MF)	anion binding	0.0004757	Moderately Informative	Direct
Molecular Function (MF)	nucleotide binding	0	Informative	Direct
Molecular Function (MF)	cofactor binding	0	Informative	Direct
Molecular Function (MF)	electron carrier activity	5.121e-08	Informative	Direct
Molecular Function (MF)	transferase activity, transferring alkyl or aryl (other than methyl) groups	1.322e-05	Informative	Direct
Molecular Function (MF)	heme binding	0	Highly Informative	Direct
Molecular Function (MF)	NADP binding	0	Highly Informative	Direct
Molecular Function (MF)	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge	0.0115	Highly Informative	Inherited
Molecular Function (MF)	dioxygenase activity	0.4195	Highly Informative	Inherited
Molecular Function (MF)	monooxygenase activity	0.1627	Highly Informative	Inherited
Cellular Component (CC)	cytoplasmic part	3.115e-06	Least Informative	Direct
Cellular Component (CC)	membrane	0.0002008	Least Informative	Direct
Cellular Component (CC)	protein complex	1	Least Informative	Inherited
Cellular Component (CC)	intracellular organelle part	1	Least Informative	Inherited
Cellular Component (CC)	intracellular membrane-bounded organelle	0.09342	Least Informative	Inherited
Cellular Component (CC)	endoplasmic reticulum	0.0001835	Moderately Informative	Direct
Cellular Component (CC)	plasma membrane	0.0007063	Moderately Informative	Direct
Cellular Component (CC)	intrinsic to membrane	0.1346	Moderately Informative	Inherited
Cellular Component (CC)	organelle envelope	0.006038	Moderately Informative	Inherited
Cellular Component (CC)	organelle membrane	0.04533	Moderately Informative	Inherited
Cellular Component (CC)	intrinsic to plasma membrane	0.0165	Informative	Inherited
Cellular Component (CC)	integral to membrane	0.4885	Informative	Inherited
Cellular Component (CC)	integral to plasma membrane	0.08434	Highly Informative	Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)

	EC term	FDR (all)	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Oxidoreductases	0	Least Informative	Direct
Enzyme Commission (EC)	Acting on NADH or NADPH	0	Moderately Informative	Direct
Enzyme Commission (EC)	Acting on paired donors, with incorporation or red	0	Moderately Informative	Direct
Enzyme Commission (EC)	Acting on a sulfur group of donors	7.826e-15	Moderately Informative	Direct
Enzyme Commission (EC)	Transferring alkyl or aryl groups, other than meth	1	Moderately Informative	Inherited
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0	Informative	Direct
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0	Informative	Direct
Enzyme Commission (EC)	Acting on iron-sulfur proteins as donors	0	Informative	Direct
Enzyme Commission (EC)	Oxidizing metal ions	1.461e-11	Informative	Direct
Enzyme Commission (EC)	With NADH or NADPH as one donor, and incorporation	0.06286	Informative	Inherited
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0	Highly Informative	Direct
Enzyme Commission (EC)	Sulfite reductase (NADPH)	0	Highly Informative	Direct
Enzyme Commission (EC)	Nitric-oxide synthase	0	Highly Informative	Direct
Enzyme Commission (EC)	With a heme protein as acceptor	0	Highly Informative	Direct
Enzyme Commission (EC)	Nitrate reductase (NADH)	0	Highly Informative	Direct
Enzyme Commission (EC)	Nitric oxide dioxygenase	1.117e-12	Highly Informative	Direct
Enzyme Commission (EC)	Nitrate reductase (NADPH)	4.944e-10	Highly Informative	Direct
Enzyme Commission (EC)	With a oxygen as acceptor	4.206e-09	Highly Informative	Direct

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)

	DO term	FDR (all)	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	immune system disease	0.07256	Least Informative	Inherited
Disease Ontology (DO)	nervous system disease	0.6514	Least Informative	Inherited
Disease Ontology (DO)	lung disease	0.001307	Moderately Informative	Inherited
Disease Ontology (DO)	endocrine system disease	0.02346	Moderately Informative	Inherited
Disease Ontology (DO)	brain disease	0.1459	Moderately Informative	Inherited
Disease Ontology (DO)	disease by infectious agent	0.2224	Moderately Informative	Inherited
Disease Ontology (DO)	malaria	2.474e-05	Informative	Direct
Disease Ontology (DO)	allergic rhinitis	2.474e-05	Informative	Direct
Disease Ontology (DO)	migraine	0.0008685	Informative	Direct
Disease Ontology (DO)	primary immunodeficiency disease	0.0615	Informative	Inherited
Disease Ontology (DO)	thyroid gland disease	0.1023	Informative	Inherited
Disease Ontology (DO)	phagocyte bactericidal dysfunction	4.877e-07	Highly Informative	Direct
Disease Ontology (DO)	hypothyroidism	3.967e-05	Highly Informative	Direct

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)

	HP term	FDR (all)	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Abnormality of the central nervous system	0	Least Informative	Direct

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)

	MP term	FDR (all)	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	cardiovascular system phenotype	0.00996	Least Informative	Inherited
Mammalian Phenotype (MP)	nervous system phenotype	0.1485	Least Informative	Inherited
Mammalian Phenotype (MP)	abnormal homeostasis	0.338	Least Informative	Inherited
Mammalian Phenotype (MP)	cellular phenotype	0.4063	Least Informative	Inherited
Mammalian Phenotype (MP)	immune system phenotype	0.4582	Least Informative	Inherited
Mammalian Phenotype (MP)	muscle phenotype	0.0006102	Moderately Informative	Direct
Mammalian Phenotype (MP)	abnormal cardiovascular system physiology	0.001009	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal lipid level	0.001521	Moderately Informative	Inherited
Mammalian Phenotype (MP)	renal/urinary system phenotype	0.001581	Moderately Informative	Inherited
Mammalian Phenotype (MP)	behavior/neurological phenotype	0.01756	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal nervous system physiology	0.02168	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal cell death	0.02534	Moderately Informative	Inherited
Mammalian Phenotype (MP)	liver/biliary system phenotype	0.04437	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal professional antigen presenting cell morphology	0.05181	Moderately Informative	Inherited
Mammalian Phenotype (MP)	respiratory system phenotype	0.0608	Moderately Informative	Inherited
Mammalian Phenotype (MP)	digestive/alimentary phenotype	0.06358	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal hormone level	0.07079	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal protein level	0.1319	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal heart morphology	0.1681	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal skeleton morphology	0.1938	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal hematopoietic cell number	0.2552	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal cardiovascular development	0.3739	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal blood vessel morphology	0.469	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal stomach morphology	2.665e-05	Informative	Direct
Mammalian Phenotype (MP)	pathological neovascularization	0.000124	Informative	Direct
Mammalian Phenotype (MP)	abnormal kidney physiology	0.0001688	Informative	Direct
Mammalian Phenotype (MP)	abnormal artery morphology	0.0002759	Informative	Direct
Mammalian Phenotype (MP)	abnormal adipose tissue amount	0.0003406	Informative	Direct
Mammalian Phenotype (MP)	impaired muscle contractility	0.0005096	Informative	Direct
Mammalian Phenotype (MP)	abnormal circulating amino acid level	0.001405	Informative	Inherited
Mammalian Phenotype (MP)	abnormal systemic arterial blood pressure	0.001496	Informative	Inherited
Mammalian Phenotype (MP)	abnormal enzyme/ coenzyme level	0.001921	Informative	Inherited
Mammalian Phenotype (MP)	abnormal circulating lipid level	0.003131	Informative	Inherited
Mammalian Phenotype (MP)	abnormal renal tubule morphology	0.003163	Informative	Inherited
Mammalian Phenotype (MP)	abnormal circulating lipoprotein level	0.004359	Informative	Inherited
Mammalian Phenotype (MP)	abnormal blood coagulation	0.004654	Informative	Inherited
Mammalian Phenotype (MP)	abnormal lung morphology	0.005316	Informative	Inherited
Mammalian Phenotype (MP)	abnormal blood vessel physiology	0.007307	Informative	Inherited
Mammalian Phenotype (MP)	abnormal renal corpuscle morphology	0.008616	Informative	Inherited
Mammalian Phenotype (MP)	abnormal macrophage morphology	0.01261	Informative	Inherited
Mammalian Phenotype (MP)	abnormal consumption behavior	0.01282	Informative	Inherited
Mammalian Phenotype (MP)	abnormal bone structure	0.02292	Informative	Inherited
Mammalian Phenotype (MP)	abnormal skeleton physiology	0.03265	Informative	Inherited
Mammalian Phenotype (MP)	abnormal gas homeostasis	0.03304	Informative	Inherited
Mammalian Phenotype (MP)	abnormal urine homeostasis	0.0399	Informative	Inherited
Mammalian Phenotype (MP)	abnormal response to injury	0.05187	Informative	Inherited
Mammalian Phenotype (MP)	seizures	0.05262	Informative	Inherited
Mammalian Phenotype (MP)	abnormal heartbeat	0.07509	Informative	Inherited
Mammalian Phenotype (MP)	increased leukocyte cell number	0.07768	Informative	Inherited
Mammalian Phenotype (MP)	abnormal heart ventricle morphology	0.07993	Informative	Inherited
Mammalian Phenotype (MP)	abnormal cholesterol level	0.09572	Informative	Inherited
Mammalian Phenotype (MP)	increased apoptosis	0.2359	Informative	Inherited
Mammalian Phenotype (MP)	pyloric sphincter hypertrophy	1.178e-09	Highly Informative	Direct
Mammalian Phenotype (MP)	decreased urine sodium level	7.878e-09	Highly Informative	Direct
Mammalian Phenotype (MP)	glomerular capillary thrombosis	1.793e-08	Highly Informative	Direct
Mammalian Phenotype (MP)	decreased systemic arterial blood pressure	1.014e-07	Highly Informative	Direct
Mammalian Phenotype (MP)	abnormal nitric oxide homeostasis	1.72e-07	Highly Informative	Direct
Mammalian Phenotype (MP)	increased blood osmolality	4.665e-07	Highly Informative	Direct
Mammalian Phenotype (MP)	increased prostaglandin level	7.681e-07	Highly Informative	Direct
Mammalian Phenotype (MP)	increased renal tubule apoptosis	9.669e-07	Highly Informative	Direct
Mammalian Phenotype (MP)	renal tubular necrosis	9.669e-07	Highly Informative	Direct
Mammalian Phenotype (MP)	polydipsia	3.493e-06	Highly Informative	Direct
Mammalian Phenotype (MP)	liver vascular congestion	3.493e-06	Highly Informative	Direct
Mammalian Phenotype (MP)	perivascular fibrosis	5.394e-06	Highly Informative	Direct
Mammalian Phenotype (MP)	decreased adiponectin level	6.156e-06	Highly Informative	Direct
Mammalian Phenotype (MP)	pulmonary vascular congestion	9.85e-06	Highly Informative	Direct
Mammalian Phenotype (MP)	increased white adipose tissue amount	1.103e-05	Highly Informative	Direct
Mammalian Phenotype (MP)	increased circulating LDL cholesterol level	1.844e-05	Highly Informative	Direct
Mammalian Phenotype (MP)	hypertension	2.027e-05	Highly Informative	Direct
Mammalian Phenotype (MP)	increased circulating alkaline phosphatase level	2.4e-05	Highly Informative	Direct
Mammalian Phenotype (MP)	cardiac interstitial fibrosis	2.829e-05	Highly Informative	Direct
Mammalian Phenotype (MP)	increased bone mineral density	4.147e-05	Highly Informative	Direct
Mammalian Phenotype (MP)	increased osteoclast cell number	4.147e-05	Highly Informative	Direct
Mammalian Phenotype (MP)	increased circulating creatinine level	4.455e-05	Highly Informative	Direct
Mammalian Phenotype (MP)	abnormal blood-brain barrier function	5.306e-05	Highly Informative	Direct
Mammalian Phenotype (MP)	increased systemic arterial systolic blood pressure	6.714e-05	Highly Informative	Direct
Mammalian Phenotype (MP)	abnormal heart ventricle pressure	0.0001169	Highly Informative	Direct
Mammalian Phenotype (MP)	glomerulosclerosis	0.0001177	Highly Informative	Direct
Mammalian Phenotype (MP)	decreased cardiac muscle contractility	0.000151	Highly Informative	Direct
Mammalian Phenotype (MP)	abnormal heart left ventricle size	0.0002361	Highly Informative	Direct
Mammalian Phenotype (MP)	increased blood urea nitrogen level	0.0003611	Highly Informative	Direct
Mammalian Phenotype (MP)	abnormal bone mineralization	0.0003733	Highly Informative	Direct
Mammalian Phenotype (MP)	decreased heart rate	0.0003867	Highly Informative	Direct
Mammalian Phenotype (MP)	abnormal blood flow velocity	0.0004045	Highly Informative	Direct
Mammalian Phenotype (MP)	reduced long term potentiation	0.0005694	Highly Informative	Direct
Mammalian Phenotype (MP)	abnormal coronary artery morphology	0.0006297	Highly Informative	Direct
Mammalian Phenotype (MP)	altered response to CNS ischemic injury	0.0007289	Highly Informative	Direct
Mammalian Phenotype (MP)	abnormal heart size	0.03686	Highly Informative	Inherited
Mammalian Phenotype (MP)	decreased susceptibility to injury	0.05035	Highly Informative	Inherited
Mammalian Phenotype (MP)	increased heart ventricle size	0.1146	Highly Informative	Inherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)

	WP term	FDR (all)	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	growth variant	0	Least Informative	Direct
Worm Phenotype (WP)	organism metabolism processing variant	0.02435	Least Informative	Inherited
Worm Phenotype (WP)	protein expression variant	0.01064	Informative	Inherited

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)

	XA term	FDR (all)	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	male genitalia	0	Least Informative	Direct
Xenopus ANatomical entity (XAN)	gonad	0	Least Informative	Direct

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)

	EC term	FDR (all)	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Oxidoreductases	0	Least Informative	Direct
Enzyme Commission (EC)	Acting on paired donors, with incorporation or reduction of molecular oxygen	0	Informative	Direct
Enzyme Commission (EC)	Acting on NADH or NADPH	0	Informative	Direct
Enzyme Commission (EC)	Acting on a sulfur group of donors	1.207e-14	Informative	Direct
Enzyme Commission (EC)	Acting on other nitrogenous compounds as donors	1.741e-08	Informative	Direct
Enzyme Commission (EC)	Transferring alkyl or aryl groups, other than methyl groups	1	Informative	Inherited
Enzyme Commission (EC)	With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor	0	Highly Informative	Direct
Enzyme Commission (EC)	Acting on iron-sulfur proteins as donors	0	Highly Informative	Direct
Enzyme Commission (EC)	With a heme protein as acceptor	0	Highly Informative	Direct
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0	Highly Informative	Direct
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0	Highly Informative	Direct
Enzyme Commission (EC)	Oxidizing metal ions	1.618e-11	Highly Informative	Direct
Enzyme Commission (EC)	With NADH or NADPH as one donor, and incorporation of one atom of oxygen	0.1956	Highly Informative	Inherited
Enzyme Commission (EC)	With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	1	Highly Informative	Inherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)

	KW term	FDR (all)	SDKW level	Annotation (direct or inherited)
Biological process	Transport	0	Least Informative	Direct
Biological process	Amino-acid biosynthesis	0.000306	Moderately Informative	Direct
Biological process	Lipid metabolism	0.008253	Moderately Informative	Inherited
Biological process	Ion transport	0.5633	Moderately Informative	Inherited
Biological process	Aromatic hydrocarbons catabolism	0	Informative	Direct
Biological process	Electron transport	0	Informative	Direct
Biological process	Steroid metabolism	0	Informative	Direct
Biological process	Lipid biosynthesis	0.0004016	Informative	Direct
Biological process	Cysteine biosynthesis	0	Highly Informative	Direct
Biological process	Detoxification	0	Highly Informative	Direct
Biological process	Luminescence	0	Highly Informative	Direct
Biological process	Nitrate assimilation	0	Highly Informative	Direct
Biological process	Pyrimidine biosynthesis	0	Highly Informative	Direct
Biological process	Sodium transport	0	Highly Informative	Direct
Biological process	Steroid biosynthesis	0	Highly Informative	Direct
Biological process	Sterol biosynthesis	0	Highly Informative	Direct
Biological process	Oxygen transport	4.622e-16	Highly Informative	Direct
Biological process	Thyroid hormones biosynthesis	5.891e-14	Highly Informative	Direct
Biological process	Cholesterol biosynthesis	2.719e-11	Highly Informative	Direct
Cellular component	Membrane	0	Least Informative	Direct
Cellular component	Endoplasmic reticulum	0	Moderately Informative	Direct
Cellular component	Mitochondrion	0	Moderately Informative	Direct
Cellular component	Mitochondrion outer membrane	0	Informative	Direct
Domain	Transmembrane	0	Least Informative	Direct
Molecular function	Metal-binding	0	Least Informative	Direct
Molecular function	Iron	0	Moderately Informative	Direct
Molecular function	NAD	0	Moderately Informative	Direct
Molecular function	Calcium	4.491e-07	Moderately Informative	Direct
Molecular function	2Fe-2S	0	Informative	Direct
Molecular function	Calmodulin-binding	0	Informative	Direct
Molecular function	FAD	0	Informative	Direct
Molecular function	Flavoprotein	0	Informative	Direct
Molecular function	FMN	0	Informative	Direct
Molecular function	Heme	0	Informative	Direct
Molecular function	Molybdenum	0	Informative	Direct
Molecular function	NADP	0	Informative	Direct
Molecular function	Sodium	0	Informative	Direct
Molecular function	Ubiquinone	0	Highly Informative	Direct
Post-translational modification	Oxidoreductase	0	Moderately Informative	Direct
Post-translational modification	Myristate	1.39e-07	Informative	Direct

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)

	UP term	FDR (all)	SDUP level	Annotation (direct or inherited)
UniPathway (UP)	aromatic compound metabolism	2.153e-12	Least Informative	Direct
UniPathway (UP)	cofactor metabolism	1	Least Informative	Inherited
UniPathway (UP)	energy metabolism	0	Moderately Informative	Direct
UniPathway (UP)	aromatic compound degradation	5.231e-05	Moderately Informative	Direct
UniPathway (UP)	UMP biosynthesis via de novo pathway	0	Informative	Direct
UniPathway (UP)	hormone metabolism	5.549e-09	Informative	Direct
UniPathway (UP)	hydrogen sulfide biosynthesis	2.169e-07	Informative	Direct
UniPathway (UP)	xenobiotic degradation	1	Informative	Inherited
UniPathway (UP)	thyroid hormone biosynthesis	0	Highly Informative	Direct
UniPathway (UP)	riboflavin biosynthesis	2.426e-15	Highly Informative	Direct
UniPathway (UP)	vanillyl-alcohol degradation	1.587e-05	Highly Informative	Direct

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 26 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a Riboflavin synthase domain-like domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 26 hidden Markov models representing the Riboflavin synthase domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

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Riboflavin synthase domain-like superfamily