SUPERFAMILY 1.75 HMM library and genome assignments server


Riboflavin synthase domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Reductase/isomerase/elongation factor common domain [ 50412] (4)
Superfamily:   Riboflavin synthase domain-like [ 63380] (3)
Families:   Riboflavin synthase [ 63783]
  Ferredoxin reductase FAD-binding domain-like [ 63381] (9)
  NADPH-cytochrome p450 reductase FAD-binding domain-like [ 50438] (3)


Superfamily statistics
Genomes (3,015) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 25,693 113,797 62
Proteins 23,085 98,873 60


Functional annotation
General category Metabolism
Detailed category Coenzyme metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Cellular Component (CC)cytoplasmic part3.221e-050.01472Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle3.331e-051Least InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 3.73e-05 Least Informative Direct
Biological Process (BP) response to stimulus 6.596e-05 Least Informative Direct
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.6471 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.6375 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) multi-organism process 4.11e-07 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 1.604e-06 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.0001764 Moderately Informative Direct
Biological Process (BP) cellular amino acid metabolic process 0.000903 Moderately Informative Direct
Biological Process (BP) reproduction 0.7251 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.9047 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.4864 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.6726 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.6683 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.6823 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.8208 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.7537 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.0515 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.2242 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.5604 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.9714 Moderately Informative Inherited
Biological Process (BP) single-organism biosynthetic process 0.1735 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.002976 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.747 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.1949 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) system process 0.8225 Moderately Informative Inherited
Biological Process (BP) ion transport 0.3916 Moderately Informative Inherited
Biological Process (BP) vitamin metabolic process 2.895e-07 Informative Direct
Biological Process (BP) response to cytokine stimulus 0.0001242 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0.0002352 Informative Direct
Biological Process (BP) regulation of ion transport 0.0005242 Informative Direct
Biological Process (BP) response to nutrient levels 0.0006629 Informative Direct
Biological Process (BP) blood circulation 0.0006762 Informative Direct
Biological Process (BP) response to organic cyclic compound 0.0008255 Informative Direct
Biological Process (BP) response to organonitrogen compound 0.0008834 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.114 Informative Inherited
Biological Process (BP) reproductive system development 0.0449 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.2056 Informative Inherited
Biological Process (BP) cation homeostasis 0.001133 Informative Inherited
Biological Process (BP) negative regulation of transport 0.001558 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.02492 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.08389 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 0.3086 Informative Inherited
Biological Process (BP) regulation of system process 0.04526 Informative Inherited
Biological Process (BP) metal ion transport 0.2248 Informative Inherited
Biological Process (BP) response to purine-containing compound 1.025e-11 Highly Informative Direct
Biological Process (BP) cytokine-mediated signaling pathway 2.788e-08 Highly Informative Direct
Biological Process (BP) glutamine family amino acid catabolic process 1.035e-07 Highly Informative Direct
Biological Process (BP) superoxide metabolic process 1.015e-06 Highly Informative Direct
Biological Process (BP) transition metal ion homeostasis 7.925e-05 Highly Informative Direct
Biological Process (BP) benzene-containing compound metabolic process 9.565e-05 Highly Informative Direct
Biological Process (BP) transition metal ion transport 0.0002497 Highly Informative Direct
Biological Process (BP) regulation of reactive oxygen species metabolic process 0.0006918 Highly Informative Direct
Biological Process (BP) regulation of blood pressure 0.0007272 Highly Informative Direct
Biological Process (BP) regulation of calcium ion transport 0.05913 Highly Informative Inherited
Biological Process (BP) hydrogen peroxide metabolic process 1 Highly Informative Inherited
Biological Process (BP) cellular response to starvation 0.2795 Highly Informative Inherited
Biological Process (BP) aging 0.004401 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.0192 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.0002049 Moderately Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on NAD(P)H 0 Informative Direct
Molecular Function (MF) nucleotide binding 0 Informative Direct
Molecular Function (MF) cofactor binding 0 Informative Direct
Molecular Function (MF) tetrapyrrole binding 1.688e-13 Informative Direct
Molecular Function (MF) electron carrier activity 1.333e-08 Informative Direct
Molecular Function (MF) transferase activity, transferring alkyl or aryl (other than methyl) groups 0.0001364 Informative Direct
Molecular Function (MF) NADP binding 0 Highly Informative Direct
Molecular Function (MF) heme binding 7.995e-16 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 1.726e-07 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0.04909 Highly Informative Inherited
Molecular Function (MF) dioxygenase activity 0.5294 Highly Informative Inherited
Molecular Function (MF) monooxygenase activity 0.2915 Highly Informative Inherited
Cellular Component (CC) membrane 0.0703 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.01472 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 0.007718 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 0.1717 Moderately Informative Inherited
Cellular Component (CC) intrinsic to plasma membrane 0.005853 Informative Inherited
Cellular Component (CC) integral to membrane 0.3765 Informative Inherited
Cellular Component (CC) membrane raft 0.0008045 Highly Informative Direct
Cellular Component (CC) integral to plasma membrane 0.01398 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on NADH or NADPH0Moderately InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors7.826e-15Moderately InformativeDirect
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than meth1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Acting on iron-sulfur proteins as donors0InformativeDirect
Enzyme Commission (EC)Oxidizing metal ions1.461e-11InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation0.06286InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Sulfite reductase (NADPH)0Highly InformativeDirect
Enzyme Commission (EC)Nitric-oxide synthase0Highly InformativeDirect
Enzyme Commission (EC)With a heme protein as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Nitrate reductase (NADH)0Highly InformativeDirect
Enzyme Commission (EC)Nitric oxide dioxygenase1.117e-12Highly InformativeDirect
Enzyme Commission (EC)Nitrate reductase (NADPH)4.944e-10Highly InformativeDirect
Enzyme Commission (EC)With a oxygen as acceptor4.206e-09Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.06736Least InformativeInherited
Disease Ontology (DO)nervous system disease0.5271Least InformativeInherited
Disease Ontology (DO)lung disease0.0007651Moderately InformativeDirect
Disease Ontology (DO)artery disease0.004335Moderately InformativeInherited
Disease Ontology (DO)endocrine system disease0.0266Moderately InformativeInherited
Disease Ontology (DO)malaria1.485e-05InformativeDirect
Disease Ontology (DO)allergic rhinitis1.572e-05InformativeDirect
Disease Ontology (DO)migraine0.0001247InformativeDirect
Disease Ontology (DO)hypertension0.0003586InformativeDirect
Disease Ontology (DO)primary immunodeficiency disease0.06407InformativeInherited
Disease Ontology (DO)thyroid gland disease0.08845InformativeInherited
Disease Ontology (DO)phagocyte bactericidal dysfunction3.189e-07Highly InformativeDirect
Disease Ontology (DO)hypothyroidism2.634e-05Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details) Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body phenotype0.001879Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.01816Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.08521Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.2226Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.3312Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.3455Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.4846Least InformativeInherited
Mammalian Phenotype (MP)muscle phenotype0.001226Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.002125Moderately InformativeInherited
Mammalian Phenotype (MP)renal/urinary system phenotype0.002528Moderately InformativeInherited
Mammalian Phenotype (MP)digestive/alimentary phenotype0.02318Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.02337Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.03284Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.05173Moderately InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.05414Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell morphology0.07167Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.08678Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.1008Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.1175Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0.1696Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.1945Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.2519Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.3378Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.4374Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal stomach morphology4.397e-05InformativeDirect
Mammalian Phenotype (MP)abnormal adipose tissue amount8.614e-05InformativeDirect
Mammalian Phenotype (MP)abnormal kidney physiology0.0002308InformativeDirect
Mammalian Phenotype (MP)abnormal bone mineral density0.000555InformativeDirect
Mammalian Phenotype (MP)impaired muscle contractility0.0007403InformativeDirect
Mammalian Phenotype (MP)abnormal lung morphology0.000921InformativeDirect
Mammalian Phenotype (MP)abnormal systemic arterial blood pressure0.001642InformativeInherited
Mammalian Phenotype (MP)abnormal circulating amino acid level0.002342InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation0.004926InformativeInherited
Mammalian Phenotype (MP)abnormal renal glomerulus morphology0.00854InformativeInherited
Mammalian Phenotype (MP)abnormal enzyme/ coenzyme level0.00869InformativeInherited
Mammalian Phenotype (MP)abnormal consumption behavior0.01006InformativeInherited
Mammalian Phenotype (MP)abnormal circulating lipoprotein level0.01223InformativeInherited
Mammalian Phenotype (MP)abnormal response to injury0.01643InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel physiology0.01719InformativeInherited
Mammalian Phenotype (MP)abnormal macrophage morphology0.01739InformativeInherited
Mammalian Phenotype (MP)abnormal cardiac muscle contractility0.02079InformativeInherited
Mammalian Phenotype (MP)abnormal ion homeostasis0.02099InformativeInherited
Mammalian Phenotype (MP)abnormal urine homeostasis0.04743InformativeInherited
Mammalian Phenotype (MP)abnormal gas homeostasis0.06603InformativeInherited
Mammalian Phenotype (MP)abnormal heartbeat0.0826InformativeInherited
Mammalian Phenotype (MP)abnormal heart ventricle morphology0.08539InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton physiology0.09077InformativeInherited
Mammalian Phenotype (MP)abnormal pituitary hormone level0.1087InformativeInherited
Mammalian Phenotype (MP)increased hematopoietic cell number0.1461InformativeInherited
Mammalian Phenotype (MP)abnormal circulating cholesterol level0.1589InformativeInherited
Mammalian Phenotype (MP)increased apoptosis0.2229InformativeInherited
Mammalian Phenotype (MP)increased cholesterol level0.2351InformativeInherited
Mammalian Phenotype (MP)abnormal white adipose tissue morphology0.3112InformativeInherited
Mammalian Phenotype (MP)pyloric sphincter hypertrophy1.184e-09Highly InformativeDirect
Mammalian Phenotype (MP)decreased urine sodium level1.623e-08Highly InformativeDirect
Mammalian Phenotype (MP)glomerular capillary thrombosis1.793e-08Highly InformativeDirect
Mammalian Phenotype (MP)decreased systemic arterial blood pressure1.834e-07Highly InformativeDirect
Mammalian Phenotype (MP)abnormal nitric oxide homeostasis1.966e-07Highly InformativeDirect
Mammalian Phenotype (MP)increased blood osmolality4.661e-07Highly InformativeDirect
Mammalian Phenotype (MP)increased renal tubule apoptosis1.193e-06Highly InformativeDirect
Mammalian Phenotype (MP)renal tubular necrosis1.193e-06Highly InformativeDirect
Mammalian Phenotype (MP)increased prostaglandin level1.455e-06Highly InformativeDirect
Mammalian Phenotype (MP)perivascular fibrosis1.956e-06Highly InformativeDirect
Mammalian Phenotype (MP)liver vascular congestion3.989e-06Highly InformativeDirect
Mammalian Phenotype (MP)polydipsia6.019e-06Highly InformativeDirect
Mammalian Phenotype (MP)decreased adiponectin level7.703e-06Highly InformativeDirect
Mammalian Phenotype (MP)pulmonary vascular congestion1.075e-05Highly InformativeDirect
Mammalian Phenotype (MP)thick ventricular wall1.797e-05Highly InformativeDirect
Mammalian Phenotype (MP)increased white adipose tissue amount2.151e-05Highly InformativeDirect
Mammalian Phenotype (MP)hypertension2.758e-05Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating LDL cholesterol level4.337e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal blood-brain barrier function4.453e-05Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating creatinine level6.082e-05Highly InformativeDirect
Mammalian Phenotype (MP)increased osteoclast cell number7.313e-05Highly InformativeDirect
Mammalian Phenotype (MP)increased systemic arterial systolic blood pressure8.75e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart ventricle pressure9.345e-05Highly InformativeDirect
Mammalian Phenotype (MP)glomerulosclerosis0.0001334Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating alkaline phosphatase level0.0001777Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating pituitary hormone level0.0002794Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart left ventricle size0.0004286Highly InformativeDirect
Mammalian Phenotype (MP)increased blood urea nitrogen level0.0004565Highly InformativeDirect
Mammalian Phenotype (MP)abnormal blood flow velocity0.0005634Highly InformativeDirect
Mammalian Phenotype (MP)decreased heart rate0.0005643Highly InformativeDirect
Mammalian Phenotype (MP)abnormal bone mineralization0.0006335Highly InformativeDirect
Mammalian Phenotype (MP)altered response to CNS ischemic injury0.001691Highly InformativeInherited
Mammalian Phenotype (MP)abnormal long term potentiation0.002722Highly InformativeInherited
Mammalian Phenotype (MP)cardiac fibrosis0.02895Highly InformativeInherited
Mammalian Phenotype (MP)abnormal heart size0.04181Highly InformativeInherited
Mammalian Phenotype (MP)increased heart ventricle size0.1184Highly InformativeInherited
Mammalian Phenotype (MP)decreased susceptibility to injury0.12Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.02435Least InformativeInherited
Worm Phenotype (WP)protein expression variant0.01064InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen0InformativeDirect
Enzyme Commission (EC)Acting on NADH or NADPH0InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors3.094e-15InformativeDirect
Enzyme Commission (EC)Acting on other nitrogenous compounds as donors1.45e-08InformativeDirect
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than methyl groups1InformativeInherited
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor0Highly InformativeDirect
Enzyme Commission (EC)Oxidizing metal ions0Highly InformativeDirect
Enzyme Commission (EC)Acting on iron-sulfur proteins as donors0Highly InformativeDirect
Enzyme Commission (EC)With a heme protein as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With a oxygen as acceptor2.872e-08Highly InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen0.2511Highly InformativeInherited
Enzyme Commission (EC)With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processAmino-acid biosynthesis0.0002709Moderately InformativeDirect
Biological processLipid metabolism0.009616Moderately InformativeInherited
Biological processIon transport0.5662Moderately InformativeInherited
Biological processAromatic hydrocarbons catabolism0InformativeDirect
Biological processElectron transport0InformativeDirect
Biological processSteroid metabolism0InformativeDirect
Biological processLipid biosynthesis0.0003293InformativeDirect
Biological processCysteine biosynthesis0Highly InformativeDirect
Biological processDetoxification0Highly InformativeDirect
Biological processLuminescence0Highly InformativeDirect
Biological processNitrate assimilation0Highly InformativeDirect
Biological processPyrimidine biosynthesis0Highly InformativeDirect
Biological processSodium transport0Highly InformativeDirect
Biological processSteroid biosynthesis0Highly InformativeDirect
Biological processSterol biosynthesis0Highly InformativeDirect
Biological processOxygen transport4.713e-16Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentMitochondrion0Moderately InformativeDirect
Cellular componentMitochondrion outer membrane0InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionFlavoprotein0Moderately InformativeDirect
Molecular functionIron0Moderately InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionCalcium9.284e-07Moderately InformativeDirect
Molecular function2Fe-2S0InformativeDirect
Molecular functionCalmodulin-binding0InformativeDirect
Molecular functionFAD0InformativeDirect
Molecular functionHeme0InformativeDirect
Molecular functionIron-sulfur0InformativeDirect
Molecular functionMolybdenum0InformativeDirect
Molecular functionNADP0InformativeDirect
Molecular functionSodium0InformativeDirect
Molecular functionUbiquinone0Highly InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationIon channel0.02248InformativeInherited
Post-translational modificationVoltage-gated channel0.000929Highly InformativeDirect
Post-translational modificationMyristate1.411e-07InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)energy metabolism0Moderately InformativeDirect
UniPathway (UP)hormone metabolism3.326e-09Moderately InformativeDirect
UniPathway (UP)hormone biosynthesis3.568e-12InformativeDirect
UniPathway (UP)thyroid hormone biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 26 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Riboflavin synthase domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 26 hidden Markov models representing the Riboflavin synthase domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]