SUPERFAMILY 1.75 HMM library and genome assignments server

Riboflavin synthase domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Reductase/isomerase/elongation factor common domain [ 50412] (4)
Superfamily:   Riboflavin synthase domain-like [ 63380] (3)
Families:   Riboflavin synthase [ 63783]
  Ferredoxin reductase FAD-binding domain-like [ 63381] (9)
  NADPH-cytochrome p450 reductase FAD-binding domain-like [ 50438] (3)


Superfamily statistics
Genomes (3,017) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 25,737 113,797 62
Proteins 23,127 98,873 60


Functional annotation
General category Metabolism
Detailed category Coenzyme metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Cellular Component (CC)intracellular membrane-bounded organelle0.00002830.9439Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.000031130.02082Least InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.00004504 Least Informative Direct
Biological Process (BP) response to stimulus 0.00007151 Least Informative Direct
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.5989 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.5129 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) oxidation-reduction process 0.00000000000507 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.00000189 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.00006118 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.000228 Moderately Informative Direct
Biological Process (BP) cellular amino acid metabolic process 0.0007553 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.838 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.05351 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.4866 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.7145 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.2544 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) reproductive process 0.451 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.828 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.006148 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.7569 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.7104 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.04472 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.006222 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.6188 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.05923 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.2442 Moderately Informative Inherited
Biological Process (BP) ion transport 0.5131 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.8511 Moderately Informative Inherited
Biological Process (BP) vitamin metabolic process 0.000000461 Informative Direct
Biological Process (BP) response to cytokine 0.0001259 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0.0002561 Informative Direct
Biological Process (BP) blood circulation 0.0006673 Informative Direct
Biological Process (BP) regulation of ion transport 0.000711 Informative Direct
Biological Process (BP) response to organonitrogen compound 0.0008181 Informative Direct
Biological Process (BP) response to organic cyclic compound 0.0008182 Informative Direct
Biological Process (BP) response to nutrient levels 0.0009016 Informative Direct
Biological Process (BP) regulation of system process 0.002513 Informative Inherited
Biological Process (BP) cation homeostasis 0.008408 Informative Inherited
Biological Process (BP) negative regulation of transport 0.00202 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.02654 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.1199 Informative Inherited
Biological Process (BP) reproductive structure development 0.09815 Informative Inherited
Biological Process (BP) cellular response to external stimulus 0.3192 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 0.3058 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.7911 Informative Inherited
Biological Process (BP) metal ion transport 0.08718 Informative Inherited
Biological Process (BP) response to purine-containing compound 0.00000000000898 Highly Informative Direct
Biological Process (BP) cytokine-mediated signaling pathway 0.00000002509 Highly Informative Direct
Biological Process (BP) glutamine family amino acid catabolic process 0.00000009951 Highly Informative Direct
Biological Process (BP) superoxide metabolic process 0.000001101 Highly Informative Direct
Biological Process (BP) electron transport chain 0.00001819 Highly Informative Direct
Biological Process (BP) benzene-containing compound metabolic process 0.00009215 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 0.00009792 Highly Informative Direct
Biological Process (BP) transition metal ion transport 0.0002528 Highly Informative Direct
Biological Process (BP) transition metal ion homeostasis 0.0004108 Highly Informative Direct
Biological Process (BP) regulation of blood pressure 0.0006112 Highly Informative Direct
Biological Process (BP) regulation of reactive oxygen species metabolic process 0.0008931 Highly Informative Direct
Biological Process (BP) regulation of calcium ion transport 0.04139 Highly Informative Inherited
Biological Process (BP) hydrogen peroxide metabolic process 1 Highly Informative Inherited
Biological Process (BP) aging 0.004715 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.01164 Highly Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.0002146 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.006765 Moderately Informative Inherited
Molecular Function (MF) nucleotide binding 0 Informative Direct
Molecular Function (MF) cofactor binding 0 Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on NAD(P)H 0 Informative Direct
Molecular Function (MF) tetrapyrrole binding 0.00000000000006622 Informative Direct
Molecular Function (MF) electron carrier activity 0.000003374 Informative Direct
Molecular Function (MF) transferase activity, transferring alkyl or aryl (other than methyl) groups 0.000136 Informative Direct
Molecular Function (MF) NADP binding 0 Highly Informative Direct
Molecular Function (MF) heme binding 8.141e-16 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 0.0000001694 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0.01741 Highly Informative Inherited
Molecular Function (MF) monooxygenase activity 0.2907 Highly Informative Inherited
Molecular Function (MF) dioxygenase activity 0.5465 Highly Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) membrane 0.1278 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.9439 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.02082 Least Informative Inherited
Cellular Component (CC) intrinsic component of membrane 0.1584 Moderately Informative Inherited
Cellular Component (CC) plasma membrane part 0.2407 Moderately Informative Inherited
Cellular Component (CC) oxidoreductase complex 0.0000000000006611 Informative Direct
Cellular Component (CC) intrinsic component of plasma membrane 0.005631 Informative Inherited
Cellular Component (CC) integral component of membrane 0.1476 Informative Inherited
Cellular Component (CC) integral component of plasma membrane 0.00601 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on NADH or NADPH0Moderately InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0.000000000000007826Moderately InformativeDirect
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than meth1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Acting on iron-sulfur proteins as donors0InformativeDirect
Enzyme Commission (EC)Oxidizing metal ions0.00000000001461InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation0.06286InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Sulfite reductase (NADPH)0Highly InformativeDirect
Enzyme Commission (EC)Nitric-oxide synthase0Highly InformativeDirect
Enzyme Commission (EC)With a heme protein as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Nitrate reductase (NADH)0Highly InformativeDirect
Enzyme Commission (EC)Nitric oxide dioxygenase0.000000000001117Highly InformativeDirect
Enzyme Commission (EC)Nitrate reductase (NADPH)0.0000000004944Highly InformativeDirect
Enzyme Commission (EC)With a oxygen as acceptor0.000000004206Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.06949Least InformativeInherited
Disease Ontology (DO)nervous system disease0.7004Least InformativeInherited
Disease Ontology (DO)obstructive lung disease0.0001349Moderately InformativeDirect
Disease Ontology (DO)artery disease0.00433Moderately InformativeInherited
Disease Ontology (DO)endocrine system disease0.02701Moderately InformativeInherited
Disease Ontology (DO)malaria0.00001487InformativeDirect
Disease Ontology (DO)allergic rhinitis0.00001664InformativeDirect
Disease Ontology (DO)migraine0.000124InformativeDirect
Disease Ontology (DO)hypertension0.0003582InformativeDirect
Disease Ontology (DO)primary immunodeficiency disease0.06392InformativeInherited
Disease Ontology (DO)thyroid gland disease0.08857InformativeInherited
Disease Ontology (DO)phagocyte bactericidal dysfunction0.0000003199Highly InformativeDirect
Disease Ontology (DO)hypothyroidism0.00002629Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details) Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body phenotype0.001907Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.01888Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.08794Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.2296Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.3015Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.3478Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.4868Least InformativeInherited
Mammalian Phenotype (MP)muscle phenotype0.001299Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.002261Moderately InformativeInherited
Mammalian Phenotype (MP)renal/urinary system phenotype0.00252Moderately InformativeInherited
Mammalian Phenotype (MP)digestive/alimentary phenotype0.02401Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.02458Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.03391Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.05022Moderately InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.05494Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.08572Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.1001Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.1219Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0.169Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.1948Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.2505Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.3129Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.3377Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.4401Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal stomach morphology0.00004943InformativeDirect
Mammalian Phenotype (MP)abnormal adipose tissue amount0.00008514InformativeDirect
Mammalian Phenotype (MP)abnormal kidney physiology0.0002228InformativeDirect
Mammalian Phenotype (MP)impaired muscle contractility0.0007569InformativeDirect
Mammalian Phenotype (MP)abnormal lung morphology0.0009771InformativeDirect
Mammalian Phenotype (MP)abnormal systemic arterial blood pressure0.001584InformativeInherited
Mammalian Phenotype (MP)abnormal circulating amino acid level0.002306InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation0.004894InformativeInherited
Mammalian Phenotype (MP)abnormal renal glomerulus morphology0.008495InformativeInherited
Mammalian Phenotype (MP)abnormal bone structure0.008623InformativeInherited
Mammalian Phenotype (MP)abnormal consumption behavior0.01044InformativeInherited
Mammalian Phenotype (MP)abnormal circulating lipoprotein level0.01259InformativeInherited
Mammalian Phenotype (MP)abnormal response to injury0.01665InformativeInherited
Mammalian Phenotype (MP)fibrosis0.01735InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel physiology0.01872InformativeInherited
Mammalian Phenotype (MP)abnormal ion homeostasis0.02031InformativeInherited
Mammalian Phenotype (MP)abnormal cardiac muscle contractility0.02068InformativeInherited
Mammalian Phenotype (MP)abnormal urine homeostasis0.04675InformativeInherited
Mammalian Phenotype (MP)abnormal phagocyte morphology0.06031InformativeInherited
Mammalian Phenotype (MP)abnormal gas homeostasis0.06669InformativeInherited
Mammalian Phenotype (MP)abnormal circulating enzyme level0.07216InformativeInherited
Mammalian Phenotype (MP)abnormal heartbeat0.08054InformativeInherited
Mammalian Phenotype (MP)abnormal heart ventricle morphology0.08974InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton physiology0.09023InformativeInherited
Mammalian Phenotype (MP)abnormal pituitary hormone level0.1075InformativeInherited
Mammalian Phenotype (MP)increased hematopoietic cell number0.1471InformativeInherited
Mammalian Phenotype (MP)abnormal circulating cholesterol level0.1574InformativeInherited
Mammalian Phenotype (MP)increased apoptosis0.2255InformativeInherited
Mammalian Phenotype (MP)increased cholesterol level0.2392InformativeInherited
Mammalian Phenotype (MP)abnormal white adipose tissue morphology0.3089InformativeInherited
Mammalian Phenotype (MP)pyloric sphincter hypertrophy0.000000001179Highly InformativeDirect
Mammalian Phenotype (MP)decreased urine sodium level0.00000001624Highly InformativeDirect
Mammalian Phenotype (MP)glomerular capillary thrombosis0.00000001793Highly InformativeDirect
Mammalian Phenotype (MP)decreased systemic arterial blood pressure0.0000001953Highly InformativeDirect
Mammalian Phenotype (MP)abnormal nitric oxide homeostasis0.0000001962Highly InformativeDirect
Mammalian Phenotype (MP)perivascular fibrosis0.0000002416Highly InformativeDirect
Mammalian Phenotype (MP)increased blood osmolality0.0000004628Highly InformativeDirect
Mammalian Phenotype (MP)increased renal tubule apoptosis0.000001193Highly InformativeDirect
Mammalian Phenotype (MP)renal tubular necrosis0.000001193Highly InformativeDirect
Mammalian Phenotype (MP)increased prostaglandin level0.00000145Highly InformativeDirect
Mammalian Phenotype (MP)liver vascular congestion0.000003975Highly InformativeDirect
Mammalian Phenotype (MP)polydipsia0.000006016Highly InformativeDirect
Mammalian Phenotype (MP)decreased adiponectin level0.000007725Highly InformativeDirect
Mammalian Phenotype (MP)pulmonary vascular congestion0.00001204Highly InformativeDirect
Mammalian Phenotype (MP)thick ventricular wall0.00001801Highly InformativeDirect
Mammalian Phenotype (MP)increased white adipose tissue amount0.00002163Highly InformativeDirect
Mammalian Phenotype (MP)hypertension0.00002785Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating LDL cholesterol level0.00004385Highly InformativeDirect
Mammalian Phenotype (MP)abnormal blood-brain barrier function0.00004436Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating creatinine level0.00005722Highly InformativeDirect
Mammalian Phenotype (MP)increased osteoclast cell number0.00007372Highly InformativeDirect
Mammalian Phenotype (MP)increased systemic arterial systolic blood pressure0.00008302Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart ventricle pressure0.00009025Highly InformativeDirect
Mammalian Phenotype (MP)glomerulosclerosis0.0001344Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating alkaline phosphatase level0.0001873Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating pituitary hormone level0.0002803Highly InformativeDirect
Mammalian Phenotype (MP)increased blood urea nitrogen level0.0004302Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart left ventricle size0.0004302Highly InformativeDirect
Mammalian Phenotype (MP)abnormal blood flow velocity0.0005501Highly InformativeDirect
Mammalian Phenotype (MP)decreased heart rate0.0005664Highly InformativeDirect
Mammalian Phenotype (MP)abnormal bone mineralization0.000658Highly InformativeDirect
Mammalian Phenotype (MP)altered response to CNS ischemic injury0.001688Highly InformativeInherited
Mammalian Phenotype (MP)abnormal long term potentiation0.002796Highly InformativeInherited
Mammalian Phenotype (MP)cardiac fibrosis0.02189Highly InformativeInherited
Mammalian Phenotype (MP)abnormal heart size0.04259Highly InformativeInherited
Mammalian Phenotype (MP)increased heart ventricle size0.1174Highly InformativeInherited
Mammalian Phenotype (MP)decreased susceptibility to injury0.1182Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.02435Least InformativeInherited
Worm Phenotype (WP)protein expression variant0.01064InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen0InformativeDirect
Enzyme Commission (EC)Acting on NADH or NADPH0InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0.000000000000002391InformativeDirect
Enzyme Commission (EC)Acting on other nitrogenous compounds as donors0.000000449InformativeDirect
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than methyl groups1InformativeInherited
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor0Highly InformativeDirect
Enzyme Commission (EC)Oxidizing metal ions0Highly InformativeDirect
Enzyme Commission (EC)Acting on iron-sulfur proteins as donors0Highly InformativeDirect
Enzyme Commission (EC)With a heme protein as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With a oxygen as acceptor0.00000002878Highly InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen0.2577Highly InformativeInherited
Enzyme Commission (EC)With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processAmino-acid biosynthesis0.0002689Moderately InformativeDirect
Biological processLipid metabolism0.009592Moderately InformativeInherited
Biological processIon transport0.5685Moderately InformativeInherited
Biological processAromatic hydrocarbons catabolism0InformativeDirect
Biological processElectron transport0InformativeDirect
Biological processSteroid metabolism0InformativeDirect
Biological processLipid biosynthesis0.0003285InformativeDirect
Biological processCysteine biosynthesis0Highly InformativeDirect
Biological processDetoxification0Highly InformativeDirect
Biological processLuminescence0Highly InformativeDirect
Biological processNitrate assimilation0Highly InformativeDirect
Biological processPyrimidine biosynthesis0Highly InformativeDirect
Biological processSodium transport0Highly InformativeDirect
Biological processSteroid biosynthesis0Highly InformativeDirect
Biological processSterol biosynthesis0Highly InformativeDirect
Biological processOxygen transport4.711e-16Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentMitochondrion0Moderately InformativeDirect
Cellular componentMitochondrion outer membrane0InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionFlavoprotein0Moderately InformativeDirect
Molecular functionIron0Moderately InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionCalcium0.000001154Moderately InformativeDirect
Molecular function2Fe-2S0InformativeDirect
Molecular functionCalmodulin-binding0InformativeDirect
Molecular functionFAD0InformativeDirect
Molecular functionHeme0InformativeDirect
Molecular functionIron-sulfur0InformativeDirect
Molecular functionMolybdenum0InformativeDirect
Molecular functionNADP0InformativeDirect
Molecular functionSodium0InformativeDirect
Molecular functionUbiquinone0Highly InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationIon channel0.02249InformativeInherited
Post-translational modificationVoltage-gated channel0.0009222Highly InformativeDirect
Post-translational modificationMyristate0.0000001471InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)aromatic compound metabolism0.000000000002166Least InformativeDirect
UniPathway (UP)cofactor metabolism1Least InformativeInherited
UniPathway (UP)energy metabolism0Moderately InformativeDirect
UniPathway (UP)aromatic compound degradation0.00006582Moderately InformativeDirect
UniPathway (UP)UMP biosynthesis via de novo pathway0InformativeDirect
UniPathway (UP)hormone biosynthesis0.000000000001322InformativeDirect
UniPathway (UP)hydrogen sulfide biosynthesis0.0000002085InformativeDirect
UniPathway (UP)xenobiotic degradation1InformativeInherited
UniPathway (UP)thyroid hormone biosynthesis0Highly InformativeDirect
UniPathway (UP)riboflavin biosynthesis0.00000000000000246Highly InformativeDirect
UniPathway (UP)vanillyl-alcohol degradation0.00001296Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 26 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Riboflavin synthase domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 26 hidden Markov models representing the Riboflavin synthase domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


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