SUPERFAMILY 1.75 HMM library and genome assignments server


TAZ domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   TAZ domain [ 57932]
Superfamily:   TAZ domain [ 57933]
Families:   TAZ domain [ 57934]


Superfamily statistics
Genomes (228) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,552 1,376 5
Proteins 1,130 970 5


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of metabolic process 4.263e-05 Least Informative Direct
Biological Process (BP) protein metabolic process 3.035e-09 Least Informative Direct
Biological Process (BP) multicellular organismal process 1.798e-12 Least Informative Direct
Biological Process (BP) developmental process 2.271e-13 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 4.055e-07 Least Informative Direct
Biological Process (BP) regulation of cellular process 5.492e-11 Least Informative Direct
Biological Process (BP) response to stimulus 0.000135 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 7.488e-07 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.1081 Least Informative Inherited
Biological Process (BP) reproduction 5.634e-08 Moderately Informative Direct
Biological Process (BP) immune system process 0.0001452 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 6.571e-12 Moderately Informative Direct
Biological Process (BP) organelle organization 7.472e-08 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 1.574e-07 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0.0006679 Moderately Informative Direct
Biological Process (BP) regulation of biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.0001393 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 6.763e-05 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0.001041 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.00219 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.02185 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.1344 Moderately Informative Inherited
Biological Process (BP) response to oxidative stress 0.0003647 Informative Direct
Biological Process (BP) response to hormone stimulus 0.0005363 Informative Direct
Biological Process (BP) positive regulation of gene expression 0.0008145 Informative Direct
Biological Process (BP) response to organic cyclic compound 0.0002154 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0 Informative Direct
Biological Process (BP) chromosome organization 0 Informative Direct
Biological Process (BP) regulation of cell cycle process 0.09752 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.06609 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.00217 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.004304 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.001153 Informative Inherited
Biological Process (BP) response to inorganic substance 0.003451 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.1611 Informative Inherited
Biological Process (BP) reproductive system development 0.007513 Informative Inherited
Biological Process (BP) internal protein amino acid acetylation 0 Highly Informative Direct
Biological Process (BP) circadian rhythm 5.724e-13 Highly Informative Direct
Biological Process (BP) histone modification 0 Highly Informative Direct
Biological Process (BP) peptidyl-lysine modification 0 Highly Informative Direct
Biological Process (BP) response to hydrogen peroxide 9.199e-10 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-dependent 0.005629 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.03144 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.01218 Highly Informative Inherited
Molecular Function (MF) binding 8.04e-06 Least Informative Direct
Molecular Function (MF) transferase activity 3.882e-14 Least Informative Direct
Molecular Function (MF) nucleic acid binding 2.466e-05 Moderately Informative Direct
Molecular Function (MF) DNA binding 1.536e-06 Informative Direct
Molecular Function (MF) chromatin binding 5.271e-06 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0 Informative Direct
Molecular Function (MF) protein binding transcription factor activity 0 Highly Informative Direct
Molecular Function (MF) transcription factor binding 3.875e-13 Highly Informative Direct
Molecular Function (MF) acetyltransferase activity 0 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1.386e-06 Least Informative Direct
Cellular Component (CC) protein complex 3.049e-06 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.08924 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.0007983 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.02235 Moderately Informative Inherited
Cellular Component (CC) nucleoplasm part 5.475e-05 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)portion of meristem tissue0.3195Least InformativeInherited
Plant ANatomical entity (PAN)rosette leaf1.293e-05InformativeDirect
Plant ANatomical entity (PAN)shoot apical meristem1.208e-09Highly InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation9.587e-15Moderately InformativeDirect
Biological processBiological rhythms1.097e-12InformativeDirect
Biological processUbl conjugation pathway4.384e-07InformativeDirect
Cellular componentNucleus7.511e-14Least InformativeDirect
DomainRepeat0.0002929Least InformativeDirect
DomainZinc-finger0Moderately InformativeDirect
DomainBromodomain3.634e-15Highly InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Post-translational modificationTransferase9.501e-07Least InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationAcyltransferase0InformativeDirect
Post-translational modificationChromatin regulator2.237e-16InformativeDirect
Post-translational modificationAcetylation7.147e-05Least InformativeDirect
Post-translational modificationIsopeptide bond3.546e-09Moderately InformativeDirect
Post-translational modificationMethylation1.375e-07Moderately InformativeDirect
Post-translational modificationUbl conjugation2.138e-07Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR000197 SSF57933 Protein matches
Abstract

TAZ (Transcription Adaptor putative Zinc finger) domains are found in CBP and P300 proteins in their N- and C-terminal regions. CBP and P300 are large nuclear proteins that interact with numerous transcription factors and viral oncoproteins, including p53 tumour suppressor protein, E1A oncoprotein, MyoD, and GATA-1, and are involved in cell growth, differentiation and apoptosis [PubMed8848831]. The TAZ2 (CH3) domain of CBP adopts a helical fold stabilised by three zinc ions, each ion bound by a HCCC-type motif. TAZ1 (CH1 domain of CBP) and TAZ2 show close sequence similarity [PubMed11023789].

More information about these proteins can be found at Protein of the Month: Zinc Fingers.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a TAZ domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the TAZ domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]