SUPERFAMILY 1.75 HMM library and genome assignments server

TAZ domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   TAZ domain [ 57932]
Superfamily:   TAZ domain [ 57933]
Families:   TAZ domain [ 57934]


Superfamily statistics
Genomes (228) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,552 1,376 5
Proteins 1,130 970 5


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of metabolic process 0.00006925 Least Informative Direct
Biological Process (BP) protein metabolic process 0.000000004099 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.0000000000009623 Least Informative Direct
Biological Process (BP) developmental process 0.0000000000002596 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.0000004808 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.00000000008796 Least Informative Direct
Biological Process (BP) response to stimulus 0.0001621 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.000001187 Least Informative Direct
Biological Process (BP) positive regulation of biological process 0.002497 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.3223 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.001877 Least Informative Inherited
Biological Process (BP) immune system process 0.0001519 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.000000000007585 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.0000001726 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0.0007042 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) reproductive process 0.0002718 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.0001609 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.000000000000267 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 0.00007669 Moderately Informative Direct
Biological Process (BP) single-organism organelle organization 0.0000000002332 Moderately Informative Direct
Biological Process (BP) tissue development 0.5945 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.00226 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.001026 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.1407 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.02337 Moderately Informative Inherited
Biological Process (BP) response to acid chemical 0.0009106 Informative Direct
Biological Process (BP) response to oxidative stress 0.0004135 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.000321 Informative Direct
Biological Process (BP) response to organic cyclic compound 0.0002093 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0.0002652 Informative Direct
Biological Process (BP) positive regulation of RNA metabolic process 0.0007359 Informative Direct
Biological Process (BP) chromosome organization 0 Informative Direct
Biological Process (BP) epithelium development 0.000007454 Informative Direct
Biological Process (BP) single organism reproductive process 0.00385 Informative Inherited
Biological Process (BP) reproductive structure development 0.05167 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.07377 Informative Inherited
Biological Process (BP) positive regulation of gene expression 0.002522 Informative Inherited
Biological Process (BP) response to inorganic substance 0.003645 Informative Inherited
Biological Process (BP) internal protein amino acid acetylation 0 Highly Informative Direct
Biological Process (BP) circadian rhythm 0.0000000000006576 Highly Informative Direct
Biological Process (BP) histone modification 0 Highly Informative Direct
Biological Process (BP) peptidyl-lysine modification 0 Highly Informative Direct
Biological Process (BP) response to hydrogen peroxide 0.000000001036 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-templated 0.008343 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.03741 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.01453 Highly Informative Inherited
Molecular Function (MF) binding 0.0000115 Least Informative Direct
Molecular Function (MF) transferase activity 0.0000000000002647 Least Informative Direct
Molecular Function (MF) nucleic acid binding 0.00004474 Moderately Informative Direct
Molecular Function (MF) nucleic acid binding transcription factor activity 0.000004838 Informative Direct
Molecular Function (MF) DNA binding 0.000001818 Informative Direct
Molecular Function (MF) chromatin binding 0.000005702 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0 Informative Direct
Molecular Function (MF) transcription factor binding transcription factor activity 0 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0.0000000000003613 Highly Informative Direct
Molecular Function (MF) acetyltransferase activity 0 Highly Informative Direct
Molecular Function (MF) transcription regulatory region DNA binding 0.0000000004819 Highly Informative Direct
Molecular Function (MF) sequence-specific DNA binding 0.005813 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.00000009876 Least Informative Direct
Cellular Component (CC) protein complex 0.1795 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.08097 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.000352 Moderately Informative Direct
Cellular Component (CC) transferase complex 0.000002667 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.02041 Moderately Informative Inherited
Cellular Component (CC) nucleoplasm part 0.000003912 Informative Direct
Cellular Component (CC) protein acetyltransferase complex 0.000000004855 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)portion of meristem tissue0.3195Least InformativeInherited
Plant ANatomical entity (PAN)rosette leaf0.00001293InformativeDirect
Plant ANatomical entity (PAN)shoot apical meristem0.000000001208Highly InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0.00000000000001002Moderately InformativeDirect
Biological processBiological rhythms0.000000000002387InformativeDirect
Biological processUbl conjugation pathway0.0000004411InformativeDirect
Cellular componentNucleus0.00000000000007714Least InformativeDirect
DomainRepeat0.0002968Least InformativeDirect
DomainZinc-finger0Moderately InformativeDirect
DomainBromodomain0.000000000000003626Highly InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Post-translational modificationTransferase0.0000009515Least InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationAcyltransferase0InformativeDirect
Post-translational modificationChromatin regulator2.24e-16InformativeDirect
Post-translational modificationAcetylation0.00007203Least InformativeDirect
Post-translational modificationIsopeptide bond0.00000000372Moderately InformativeDirect
Post-translational modificationMethylation0.0000001368Moderately InformativeDirect
Post-translational modificationUbl conjugation0.0000002224Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR000197 SSF57933 Protein matches
Abstract

TAZ (Transcription Adaptor putative Zinc finger) domains are found in CBP and P300 proteins in their N- and C-terminal regions. CBP and P300 are large nuclear proteins that interact with numerous transcription factors and viral oncoproteins, including p53 tumour suppressor protein, E1A oncoprotein, MyoD, and GATA-1, and are involved in cell growth, differentiation and apoptosis [PubMed8848831]. The TAZ2 (CH3) domain of CBP adopts a helical fold stabilised by three zinc ions, each ion bound by a HCCC-type motif. TAZ1 (CH1 domain of CBP) and TAZ2 show close sequence similarity [PubMed11023789].

More information about these proteins can be found at Protein of the Month: Zinc Fingers.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a TAZ domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the TAZ domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]