SUPERFAMILY 1.75 HMM library and genome assignments server

Cysteine-rich domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Cysteine-rich domain [ 57888]
Superfamily:   Cysteine-rich domain [ 57889] (3)
Families:   Protein kinase cysteine-rich domain (cys2, phorbol-binding domain) [ 57890] (6)
  TFIIH p44 subunit cysteine-rich domain [ 57899]
  C1-like domain [ 111463]


Superfamily statistics
Genomes (497) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 15,342 14,257 8
Proteins 10,091 10,031 8


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process0.0028310.000003351Least InformativeInherited
Biological Process (BP)regulation of signal transduction0.000010650.0000008305Moderately InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 0.000003351 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.000000000002055 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.000001691 Least Informative Direct
Biological Process (BP) localization 0.000001835 Least Informative Direct
Biological Process (BP) positive regulation of biological process 0.00001169 Least Informative Direct
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of signal transduction 0.0000008305 Moderately Informative Direct
Biological Process (BP) regulation of phosphorus metabolic process 0 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) single-organism organelle organization 0.000000000000003707 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 0.0000000005346 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0.000000004943 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.00000001527 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.00000004089 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.0000000476 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 0.00000009377 Moderately Informative Direct
Biological Process (BP) signal transduction 0.0000001065 Moderately Informative Direct
Biological Process (BP) immune system process 0.0000005583 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0.00003405 Moderately Informative Direct
Biological Process (BP) cellular localization 0.000155 Moderately Informative Direct
Biological Process (BP) nervous system development 0.000362 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.0007263 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.6089 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.756 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.5039 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.2255 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.1244 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.2926 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.01485 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.002519 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.9043 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.7552 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.2991 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) reproductive process 0.08136 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.6403 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleoside metabolic process 0 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0 Informative Direct
Biological Process (BP) generation of neurons 0 Informative Direct
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) cytoskeleton organization 0 Informative Direct
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.000000000000001913 Informative Direct
Biological Process (BP) organelle localization 0.000000000000009016 Informative Direct
Biological Process (BP) positive regulation of catabolic process 0.000000000001126 Informative Direct
Biological Process (BP) intracellular signal transduction 0.000000000008168 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.00000000005105 Informative Direct
Biological Process (BP) negative regulation of cell death 0.000000000101 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.000000000186 Informative Direct
Biological Process (BP) secretion by cell 0.00000008411 Informative Direct
Biological Process (BP) regulation of organelle organization 0.0000005921 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 0.000001473 Informative Direct
Biological Process (BP) locomotion 0.000001533 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.000005196 Informative Direct
Biological Process (BP) regulation of response to wounding 0.000005303 Informative Direct
Biological Process (BP) microtubule-based process 0.0000184 Informative Direct
Biological Process (BP) regulation of body fluid levels 0.00003348 Informative Direct
Biological Process (BP) regulation of locomotion 0.0001364 Informative Direct
Biological Process (BP) response to organonitrogen compound 0.0001571 Informative Direct
Biological Process (BP) negative regulation of transport 0.0002274 Informative Direct
Biological Process (BP) leukocyte activation 0.0002882 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.0002921 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.0003263 Informative Direct
Biological Process (BP) cellular component movement 0.0007677 Informative Direct
Biological Process (BP) synaptic transmission 0.0008708 Informative Direct
Biological Process (BP) regulation of secretion 0.08824 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.1222 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.005219 Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 0.3492 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.001115 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.2576 Informative Inherited
Biological Process (BP) organ morphogenesis 0.5531 Informative Inherited
Biological Process (BP) growth 0.009815 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.2244 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.335 Informative Inherited
Biological Process (BP) regulation of MAPK cascade 0.478 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.2721 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.00516 Informative Inherited
Biological Process (BP) positive regulation of intracellular signal transduction 0.1725 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.9987 Informative Inherited
Biological Process (BP) single-organism intracellular transport 1 Informative Inherited
Biological Process (BP) single-organism cellular localization 0.6671 Informative Inherited
Biological Process (BP) regulation of cell activation 0.009463 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.1105 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 1 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.8599 Informative Inherited
Biological Process (BP) sensory organ development 0.8454 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.711 Informative Inherited
Biological Process (BP) cell proliferation 0.00532 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.0659 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.07185 Informative Inherited
Biological Process (BP) response to nutrient levels 1 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 1 Informative Inherited
Biological Process (BP) proteolysis 1 Informative Inherited
Biological Process (BP) cell projection organization 0.001175 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 0.6155 Informative Inherited
Biological Process (BP) immune response 0.2441 Informative Inherited
Biological Process (BP) immune effector process 0.008968 Informative Inherited
Biological Process (BP) localization of cell 0.005709 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) regulation of cell development 0.003739 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.03861 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.4885 Informative Inherited
Biological Process (BP) tube development 0.4293 Informative Inherited
Biological Process (BP) epithelium development 0.04222 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.3765 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.06628 Informative Inherited
Biological Process (BP) sexual reproduction 0.1991 Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.6026 Informative Inherited
Biological Process (BP) single organism reproductive process 0.8083 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.04735 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.09998 Informative Inherited
Biological Process (BP) protein catabolic process 1 Informative Inherited
Biological Process (BP) organelle fission 0.7733 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) positive regulation of transport 0.5414 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.4826 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.5406 Informative Inherited
Biological Process (BP) cell cycle process 0.293 Informative Inherited
Biological Process (BP) cell division 0.131 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.02172 Informative Inherited
Biological Process (BP) neurotransmitter transport 0 Highly Informative Direct
Biological Process (BP) protein phosphorylation 0 Highly Informative Direct
Biological Process (BP) small GTPase mediated signal transduction 0.000000000000003707 Highly Informative Direct
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 0.00000000000005988 Highly Informative Direct
Biological Process (BP) exocytosis 0.00000000000006308 Highly Informative Direct
Biological Process (BP) hemostasis 0.00000000000008518 Highly Informative Direct
Biological Process (BP) regulation of cellular response to insulin stimulus 0.0000000002208 Highly Informative Direct
Biological Process (BP) regulation of wound healing 0.0000000002473 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0.0000000003995 Highly Informative Direct
Biological Process (BP) regulation of neurotransmitter levels 0.000000001274 Highly Informative Direct
Biological Process (BP) coagulation 0.00000001224 Highly Informative Direct
Biological Process (BP) morphogenesis of embryonic epithelium 0.00000008295 Highly Informative Direct
Biological Process (BP) positive regulation of angiogenesis 0.0000005679 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0.0000006022 Highly Informative Direct
Biological Process (BP) regulation of synaptic transmission 0.000002071 Highly Informative Direct
Biological Process (BP) regulation of phospholipase activity 0.000002167 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0.000002514 Highly Informative Direct
Biological Process (BP) cytokinesis 0.000003221 Highly Informative Direct
Biological Process (BP) positive regulation of GTPase activity 0.000004336 Highly Informative Direct
Biological Process (BP) peptidyl-serine modification 0.000004709 Highly Informative Direct
Biological Process (BP) B cell activation 0.000009606 Highly Informative Direct
Biological Process (BP) signal release 0.000009965 Highly Informative Direct
Biological Process (BP) actin filament organization 0.00001691 Highly Informative Direct
Biological Process (BP) post-embryonic organ development 0.0000296 Highly Informative Direct
Biological Process (BP) cell growth 0.00009915 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.0001935 Highly Informative Direct
Biological Process (BP) regulation of T cell activation 0.0002536 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.0004304 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 0.0005597 Highly Informative Direct
Biological Process (BP) regulation of muscle system process 0.0006859 Highly Informative Direct
Biological Process (BP) wound healing 0.0008968 Highly Informative Direct
Biological Process (BP) positive regulation of cell activation 0.3469 Highly Informative Inherited
Biological Process (BP) regulation of exocytosis 0.002253 Highly Informative Inherited
Biological Process (BP) negative regulation of nervous system development 0.7031 Highly Informative Inherited
Biological Process (BP) regulation of protein complex disassembly 0.06858 Highly Informative Inherited
Biological Process (BP) developmental growth 0.09855 Highly Informative Inherited
Biological Process (BP) cell projection morphogenesis 1 Highly Informative Inherited
Biological Process (BP) cellular response to peptide 0.001967 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 0.009085 Highly Informative Inherited
Biological Process (BP) positive regulation of neurogenesis 0.772 Highly Informative Inherited
Biological Process (BP) regulation of actin cytoskeleton organization 0.783 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.0144 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.8969 Highly Informative Inherited
Biological Process (BP) chemotaxis 0.01242 Highly Informative Inherited
Biological Process (BP) leukocyte migration 0.03447 Highly Informative Inherited
Biological Process (BP) microtubule-based movement 0.4502 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 0.09745 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.2865 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 0.08641 Highly Informative Inherited
Biological Process (BP) cell fate commitment 0.4402 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.03496 Highly Informative Inherited
Biological Process (BP) regulation of myeloid cell differentiation 0.2315 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell differentiation 0.1584 Highly Informative Inherited
Biological Process (BP) response to alkaloid 0.2118 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.001524 Highly Informative Inherited
Biological Process (BP) leukocyte proliferation 0.001735 Highly Informative Inherited
Biological Process (BP) histone modification 0.6323 Highly Informative Inherited
Biological Process (BP) respiratory system development 0.001139 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.1219 Highly Informative Inherited
Biological Process (BP) regulation of nuclear division 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.001407 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.1182 Highly Informative Inherited
Biological Process (BP) positive regulation of cell division 0.2827 Highly Informative Inherited
Biological Process (BP) regulation of Rho protein signal transduction 0.02594 Highly Informative Inherited
Biological Process (BP) regulation of Ras GTPase activity 0.003068 Highly Informative Inherited
Biological Process (BP) positive regulation of response to external stimulus 0.8605 Highly Informative Inherited
Biological Process (BP) ubiquitin-dependent protein catabolic process 0.3613 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.06165 Highly Informative Inherited
Biological Process (BP) leukocyte mediated immunity 0.01004 Highly Informative Inherited
Biological Process (BP) neuron projection development 0.8158 Highly Informative Inherited
Biological Process (BP) establishment of synaptic vesicle localization 0.2111 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.03233 Highly Informative Inherited
Biological Process (BP) positive regulation of cell migration 0.0079 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.9482 Highly Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 0.1251 Highly Informative Inherited
Biological Process (BP) proteasomal protein catabolic process 0.1203 Highly Informative Inherited
Biological Process (BP) nuclear division 0.06453 Highly Informative Inherited
Biological Process (BP) mitotic cell cycle phase transition 0.1837 Highly Informative Inherited
Biological Process (BP) regulation of microtubule polymerization or depolymerization 1 Highly Informative Inherited
Biological Process (BP) negative regulation of cytoskeleton organization 0.8021 Highly Informative Inherited
Biological Process (BP) regulation of adaptive immune response 0.03241 Highly Informative Inherited
Biological Process (BP) myeloid leukocyte activation 0.2954 Highly Informative Inherited
Biological Process (BP) leukocyte activation involved in immune response 0.7812 Highly Informative Inherited
Biological Process (BP) positive regulation of epithelial cell proliferation 0.04746 Highly Informative Inherited
Biological Process (BP) epithelial tube formation 0.004184 Highly Informative Inherited
Biological Process (BP) neural tube development 0.07295 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 0.9063 Highly Informative Inherited
Molecular Function (MF) binding 0.000000000007896 Least Informative Direct
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0.000003618 Moderately Informative Direct
Molecular Function (MF) structural molecule activity 0.07566 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.2051 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.009418 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 0.2917 Moderately Informative Inherited
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.000000000000002376 Informative Direct
Molecular Function (MF) enzyme binding 0.0000000002158 Informative Direct
Molecular Function (MF) enzyme activator activity 0.0000004927 Informative Direct
Molecular Function (MF) lipid binding 0.000003878 Informative Direct
Molecular Function (MF) purine ribonucleoside binding 0.00003719 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0.00004199 Informative Direct
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) nucleotide binding 0.02203 Informative Inherited
Molecular Function (MF) protein complex binding 0.006636 Informative Inherited
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.006755 Informative Inherited
Molecular Function (MF) molecular transducer activity 0.3895 Informative Inherited
Molecular Function (MF) receptor activity 1 Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 0.1546 Informative Inherited
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0 Highly Informative Direct
Molecular Function (MF) ATP binding 0.0000001158 Highly Informative Direct
Molecular Function (MF) GTPase activator activity 0.000002298 Highly Informative Direct
Molecular Function (MF) tubulin binding 0.00002279 Highly Informative Direct
Molecular Function (MF) transcription factor binding transcription factor activity 1 Highly Informative Inherited
Molecular Function (MF) Ras GTPase binding 0.5163 Highly Informative Inherited
Molecular Function (MF) small GTPase regulator activity 0.2753 Highly Informative Inherited
Molecular Function (MF) kinase binding 0.2647 Highly Informative Inherited
Molecular Function (MF) protein kinase activity 0.3051 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.00009338 Least Informative Direct
Cellular Component (CC) protein complex 0.815 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.3049 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.952 Least Informative Inherited
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0 Moderately Informative Direct
Cellular Component (CC) cytosol 0.0000007537 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) transferase complex 0.2207 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) plasma membrane part 0.01081 Moderately Informative Inherited
Cellular Component (CC) membrane region 0.8313 Moderately Informative Inherited
Cellular Component (CC) synapse 0 Informative Direct
Cellular Component (CC) cell leading edge 0 Informative Direct
Cellular Component (CC) cell junction 0.00000000000003272 Informative Direct
Cellular Component (CC) cell cortex 0.00000009799 Informative Direct
Cellular Component (CC) DNA-directed RNA polymerase complex 0.000002684 Informative Direct
Cellular Component (CC) neuron projection 0.001304 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) plasma membrane region 0.02898 Informative Inherited
Cellular Component (CC) actin cytoskeleton 0.3509 Informative Inherited
Cellular Component (CC) nucleoplasm part 0.05018 Informative Inherited
Cellular Component (CC) cell body 0.000000000000008925 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.000000000006452 Highly Informative Direct
Cellular Component (CC) cell division site part 0.000000282 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 0.0000491 Highly Informative Direct
Cellular Component (CC) dendrite 0.4561 Highly Informative Inherited
Cellular Component (CC) spindle 0.01552 Highly Informative Inherited
Cellular Component (CC) microtubule organizing center 1 Highly Informative Inherited
Cellular Component (CC) cortical cytoskeleton 0.02152 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0.0007862Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0.7416Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.000007101InformativeDirect
Enzyme Commission (EC)Diacylglycerol kinase0Highly InformativeDirect
Enzyme Commission (EC)Protein kinase C0Highly InformativeDirect
Enzyme Commission (EC)Protein-disulfide reductase0.00000000004229Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.4003Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of head and neck0.5123Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.7217Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vertebral column0.1681Moderately InformativeInherited
Phenotypic Abnormality (PA)Generalized abnormality of skin0.3382Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the neck0.02214InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hair0.1088InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin morphology0.1394InformativeInherited
Phenotypic Abnormality (PA)Low posterior hairline0.0002057Highly InformativeDirect
Phenotypic Abnormality (PA)Irregular hyperpigmentation0.0006148Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the spinal cord0.004043Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.002652Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.01199Least InformativeInherited
Mammalian Phenotype (MP)abnormal leukopoiesis0.1217Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.3077Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal T cell morphology0.9576InformativeInherited
Mammalian Phenotype (MP)abnormal T cell selection0.01133Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.00001332Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.000145Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.427Least InformativeInherited
Worm Phenotype (WP)chemical response variant0.03891Moderately InformativeInherited
Worm Phenotype (WP)pattern of transgene expression variant0.09207Moderately InformativeInherited
Worm Phenotype (WP)germ cell morphology variant0.2026Moderately InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant0.2254Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.3357Moderately InformativeInherited
Worm Phenotype (WP)organism pathogen response variant0.000004936InformativeDirect
Worm Phenotype (WP)chemotaxis variant0.0003274InformativeDirect
Worm Phenotype (WP)cell stress response variant0.01106InformativeInherited
Worm Phenotype (WP)protein expression variant0.05202InformativeInherited
Worm Phenotype (WP)rachis morphology variant0.6657InformativeInherited
Worm Phenotype (WP)drug induced gene expression variant0.000000000702Highly InformativeDirect
Worm Phenotype (WP)response to injury variant0.0000001358Highly InformativeDirect
Worm Phenotype (WP)odorant positive chemotaxis variant0.000002889Highly InformativeDirect
Worm Phenotype (WP)isothermal tracking behavior variant0.00001285Highly InformativeDirect
Worm Phenotype (WP)pharyngeal pumping variant0.00001575Highly InformativeDirect
Worm Phenotype (WP)protein subcellular localization variant0.00004394Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)mitotic cell cycle defective0.00023InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0.2168Least InformativeInherited
Fly Anatomy (FA)organ system0.3353Least InformativeInherited
Fly Anatomy (FA)embryonic/larval integumentary system0.0003041InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0.1917Least InformativeInherited
Plant ANatomical entity (PAN)root epidermis0.000007751InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0.7987Moderately InformativeInherited
Enzyme Commission (EC)Acting on a sulfur group of donors0.0008014InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0.4177InformativeInherited
Enzyme Commission (EC)Diacylglycerol kinase (ATP)0Highly InformativeDirect
Enzyme Commission (EC)Protein kinase C0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.000007276Highly InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0.00008053Highly InformativeDirect

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)alimentary tract and metabolism0.8602Least InformativeInherited
Drugbank ATC_code (DB)other plain vitamin preparations1Moderately InformativeInherited
Drugbank ATC_code (DB)hormone antagonists and related agents0.000000000000002293InformativeDirect
Drugbank ATC_code (DB)tocopherol (vit e)0.000003651InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0Moderately InformativeDirect
Biological processDifferentiation0Moderately InformativeDirect
Biological processCell cycle0.00000252Moderately InformativeDirect
Biological processAngiogenesis0.000000000000002085InformativeDirect
Biological processInflammatory response0.000000000001505InformativeDirect
Biological processCell adhesion0.000000000851InformativeDirect
Biological processNeurogenesis0.000000007417InformativeDirect
Biological processBiological rhythms0.000002444InformativeDirect
Biological processMitosis0.0006411InformativeDirect
Biological processExocytosis0.000000000000008684Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentNucleus0.000000000001068Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentGolgi apparatus0.000000000000007264Moderately InformativeDirect
Cellular componentCell projection0.000000000005304Moderately InformativeDirect
Cellular componentEndosome0.00001894Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.0002572Moderately InformativeDirect
Cellular componentCell membrane0.0005065Moderately InformativeDirect
Cellular componentMicrotubule0.000000008415InformativeDirect
Cellular componentSynapse0.5875InformativeInherited
Cellular componentSynaptosome0.00002636Highly InformativeDirect
DiseaseProto-oncogene0.000000000000001525Moderately InformativeDirect
DiseaseTumor suppressor0.000009675Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainZinc-finger0Moderately InformativeDirect
DomainSH2 domain0.00003537InformativeDirect
DomainSH3 domain0.00007554InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionNucleotide-binding4.62e-16Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.00001562Moderately InformativeDirect
Post-translational modificationGTPase activation0InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationChromatin regulator0.0001116InformativeDirect
Post-translational modificationMyosin0.00000001846Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cysteine-rich domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the Cysteine-rich domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · Internal database links ]