SUPERFAMILY 1.75 HMM library and genome assignments server


Cysteine-rich domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Cysteine-rich domain [ 57888]
Superfamily:   Cysteine-rich domain [ 57889] (3)
Families:   Protein kinase cysteine-rich domain (cys2, phorbol-binding domain) [ 57890] (6)
  TFIIH p44 subunit cysteine-rich domain [ 57899]
  C1-like domain [ 111463]


Superfamily statistics
Genomes (485) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 14,577 0 8
Proteins 9,538 0 8


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process0.0023167.664e-07Least InformativeInherited
Biological Process (BP)regulation of signal transduction8.43e-065.551e-07Moderately InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 7.664e-07 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) localization 3.334e-08 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 2.947e-06 Least Informative Direct
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of signal transduction 5.551e-07 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 1.657e-13 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 6.248e-12 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 2.846e-10 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 4.457e-10 Moderately Informative Direct
Biological Process (BP) immune system process 9.254e-10 Moderately Informative Direct
Biological Process (BP) organelle organization 1.619e-09 Moderately Informative Direct
Biological Process (BP) signal transduction 1.723e-07 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 6.952e-06 Moderately Informative Direct
Biological Process (BP) nervous system development 2.98e-05 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 4.931e-05 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 8.696e-05 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.000562 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.02286 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.01519 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.9018 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.6076 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.2363 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.6753 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.5417 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.7624 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.0467 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.007228 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.6107 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.1746 Moderately Informative Inherited
Biological Process (BP) system process 0.04039 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.002241 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) cytoskeleton organization 0 Informative Direct
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0 Informative Direct
Biological Process (BP) generation of neurons 0 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 0 Informative Direct
Biological Process (BP) organelle localization 0 Informative Direct
Biological Process (BP) regulation of apoptotic process 0 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0 Informative Direct
Biological Process (BP) intracellular signal transduction 3.16e-12 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 4.49e-12 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 8.326e-12 Informative Direct
Biological Process (BP) negative regulation of cell death 2.297e-11 Informative Direct
Biological Process (BP) microtubule-based process 6.289e-07 Informative Direct
Biological Process (BP) locomotion 2.495e-06 Informative Direct
Biological Process (BP) regulation of organelle organization 7.174e-06 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 8.701e-06 Informative Direct
Biological Process (BP) response to wounding 1.643e-05 Informative Direct
Biological Process (BP) secretion by cell 3.401e-05 Informative Direct
Biological Process (BP) cellular component morphogenesis 4.883e-05 Informative Direct
Biological Process (BP) regulation of body fluid levels 5.024e-05 Informative Direct
Biological Process (BP) mitotic cell cycle 8.025e-05 Informative Direct
Biological Process (BP) positive regulation of developmental process 0.0001182 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.0001482 Informative Direct
Biological Process (BP) regulation of locomotion 0.0001769 Informative Direct
Biological Process (BP) immune effector process 0.0001917 Informative Direct
Biological Process (BP) response to organonitrogen compound 0.0002055 Informative Direct
Biological Process (BP) single-organism behavior 0.000212 Informative Direct
Biological Process (BP) regulation of nervous system development 0.000337 Informative Direct
Biological Process (BP) positive regulation of immune system process 0.0004837 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.0007931 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.109 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) regulation of response to stress 1 Informative Inherited
Biological Process (BP) organ morphogenesis 0.184 Informative Inherited
Biological Process (BP) cell projection organization 0.09139 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.1891 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.3107 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.7993 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.9831 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.0585 Informative Inherited
Biological Process (BP) cell cycle process 0.1192 Informative Inherited
Biological Process (BP) regulation of cell development 0.00191 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.9848 Informative Inherited
Biological Process (BP) muscle structure development 0.9416 Informative Inherited
Biological Process (BP) regulation of system process 0.196 Informative Inherited
Biological Process (BP) regulation of secretion 0.157 Informative Inherited
Biological Process (BP) sensory organ development 0.2702 Informative Inherited
Biological Process (BP) programmed cell death 0.3472 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 1 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.8729 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) defense response 0.3532 Informative Inherited
Biological Process (BP) secondary metabolic process 0.01331 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.004725 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.2002 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.2966 Informative Inherited
Biological Process (BP) response to nutrient levels 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.1585 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.9718 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.05573 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.07952 Informative Inherited
Biological Process (BP) epithelium development 0.01067 Informative Inherited
Biological Process (BP) transmission of nerve impulse 0.06531 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 0.5871 Informative Inherited
Biological Process (BP) protein complex assembly 1 Informative Inherited
Biological Process (BP) cell-cell signaling 0.03493 Informative Inherited
Biological Process (BP) growth 0.001556 Informative Inherited
Biological Process (BP) cellular component movement 0.01026 Informative Inherited
Biological Process (BP) localization of cell 0.02033 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.0467 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) sexual reproduction 0.01689 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.01988 Informative Inherited
Biological Process (BP) single organism reproductive process 0.124 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.03959 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.4431 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.04488 Informative Inherited
Biological Process (BP) tube development 0.007515 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.1437 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.9336 Informative Inherited
Biological Process (BP) pigment metabolic process 0.003329 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) leukocyte activation 0.001637 Informative Inherited
Biological Process (BP) immune response 0.02907 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 1 Informative Inherited
Biological Process (BP) protein phosphorylation 0 Highly Informative Direct
Biological Process (BP) small GTPase mediated signal transduction 1.422e-14 Highly Informative Direct
Biological Process (BP) regulation of wound healing 5.37e-14 Highly Informative Direct
Biological Process (BP) hemostasis 6.012e-14 Highly Informative Direct
Biological Process (BP) neurotransmitter transport 1.9e-13 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 6.094e-13 Highly Informative Direct
Biological Process (BP) exocytosis 6.294e-13 Highly Informative Direct
Biological Process (BP) morphogenesis of embryonic epithelium 4.227e-11 Highly Informative Direct
Biological Process (BP) regulation of cellular response to insulin stimulus 1.775e-10 Highly Informative Direct
Biological Process (BP) regulation of synaptic transmission 2.101e-10 Highly Informative Direct
Biological Process (BP) regulation of neurotransmitter levels 4.421e-08 Highly Informative Direct
Biological Process (BP) coagulation 5.06e-08 Highly Informative Direct
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 3.9e-07 Highly Informative Direct
Biological Process (BP) positive regulation of Ras GTPase activity 9.433e-07 Highly Informative Direct
Biological Process (BP) regulation of phospholipase activity 1.915e-06 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 2.19e-06 Highly Informative Direct
Biological Process (BP) respiratory system development 2.197e-06 Highly Informative Direct
Biological Process (BP) establishment of vesicle localization 2.76e-06 Highly Informative Direct
Biological Process (BP) regulation of hemostasis 3.971e-06 Highly Informative Direct
Biological Process (BP) eye morphogenesis 5.923e-06 Highly Informative Direct
Biological Process (BP) regulation of coagulation 7.147e-06 Highly Informative Direct
Biological Process (BP) B cell activation 8.455e-06 Highly Informative Direct
Biological Process (BP) cell junction organization 9.216e-06 Highly Informative Direct
Biological Process (BP) peptidyl-serine modification 3.644e-05 Highly Informative Direct
Biological Process (BP) cell division 4.043e-05 Highly Informative Direct
Biological Process (BP) regulation of adaptive immune response based on somatic recombination of immune receptors built from 4.87e-05 Highly Informative Direct
Biological Process (BP) post-embryonic organ development 5.262e-05 Highly Informative Direct
Biological Process (BP) actin filament organization 6.28e-05 Highly Informative Direct
Biological Process (BP) signal release 7.074e-05 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 0.000109 Highly Informative Direct
Biological Process (BP) regulation of T cell activation 0.0002172 Highly Informative Direct
Biological Process (BP) regulation of Rho GTPase activity 0.0002366 Highly Informative Direct
Biological Process (BP) regulation of angiogenesis 0.0002454 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.0003263 Highly Informative Direct
Biological Process (BP) regulation of protein depolymerization 0.0003603 Highly Informative Direct
Biological Process (BP) positive regulation of cytokine production 0.0003721 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 0.0003924 Highly Informative Direct
Biological Process (BP) muscle fiber development 0.0004033 Highly Informative Direct
Biological Process (BP) cell growth 0.0004226 Highly Informative Direct
Biological Process (BP) positive regulation of cell differentiation 0.0005175 Highly Informative Direct
Biological Process (BP) neural precursor cell proliferation 0.0005523 Highly Informative Direct
Biological Process (BP) wound healing 0.0005592 Highly Informative Direct
Biological Process (BP) learning or memory 0.0006299 Highly Informative Direct
Biological Process (BP) regulation of ERK1 and ERK2 cascade 0.0009906 Highly Informative Direct
Biological Process (BP) negative regulation of protein complex disassembly 0.005183 Highly Informative Inherited
Biological Process (BP) developmental growth 0.1469 Highly Informative Inherited
Biological Process (BP) cell projection morphogenesis 1 Highly Informative Inherited
Biological Process (BP) microtubule-based movement 0.5767 Highly Informative Inherited
Biological Process (BP) cellular response to peptide 0.002078 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 0.1789 Highly Informative Inherited
Biological Process (BP) cell fate commitment 0.0806 Highly Informative Inherited
Biological Process (BP) regulation of actin cytoskeleton organization 0.7421 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 0.9008 Highly Informative Inherited
Biological Process (BP) positive regulation of cell activation 0.1844 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.006609 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.2513 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.8469 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.2069 Highly Informative Inherited
Biological Process (BP) chemotaxis 0.01386 Highly Informative Inherited
Biological Process (BP) leukocyte migration 0.0516 Highly Informative Inherited
Biological Process (BP) regulation of behavior 0.331 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.4584 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.05985 Highly Informative Inherited
Biological Process (BP) regulation of myeloid cell differentiation 0.3064 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell differentiation 0.2108 Highly Informative Inherited
Biological Process (BP) response to alkaloid 0.2016 Highly Informative Inherited
Biological Process (BP) photoreceptor cell differentiation 0.17 Highly Informative Inherited
Biological Process (BP) leukocyte proliferation 0.01189 Highly Informative Inherited
Biological Process (BP) histone modification 1 Highly Informative Inherited
Biological Process (BP) innate immune response 0.2504 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic process 0.001312 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.03734 Highly Informative Inherited
Biological Process (BP) regulation of cell division 0.004345 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 0.02406 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 0.02698 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.06471 Highly Informative Inherited
Biological Process (BP) leukocyte mediated immunity 0.1508 Highly Informative Inherited
Biological Process (BP) synaptic vesicle localization 0.1927 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.00587 Highly Informative Inherited
Biological Process (BP) positive regulation of cell migration 0.008333 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.6752 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.003123 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.4714 Highly Informative Inherited
Biological Process (BP) stem cell proliferation 0.001619 Highly Informative Inherited
Biological Process (BP) developmental maturation 0.001781 Highly Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 0.1244 Highly Informative Inherited
Biological Process (BP) mitosis 0.01361 Highly Informative Inherited
Biological Process (BP) mitotic cell cycle phase transition 0.7372 Highly Informative Inherited
Biological Process (BP) regulation of microtubule polymerization or depolymerization 1 Highly Informative Inherited
Biological Process (BP) negative regulation of cytoskeleton organization 0.8535 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.219 Highly Informative Inherited
Biological Process (BP) positive regulation of adaptive immune response 0.02047 Highly Informative Inherited
Biological Process (BP) myeloid leukocyte activation 0.2914 Highly Informative Inherited
Biological Process (BP) leukocyte activation involved in immune response 0.772 Highly Informative Inherited
Biological Process (BP) regulation of neural precursor cell proliferation 0.01713 Highly Informative Inherited
Biological Process (BP) positive regulation of epithelial cell proliferation 0.1736 Highly Informative Inherited
Biological Process (BP) epithelial tube formation 0.1143 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 0.9014 Highly Informative Inherited
Molecular Function (MF) binding 2.751e-14 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) enzyme regulator activity 0 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.01059 Moderately Informative Inherited
Molecular Function (MF) structural molecule activity 0.06994 Moderately Informative Inherited
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) GTPase regulator activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 7.982e-16 Informative Direct
Molecular Function (MF) enzyme binding 4.852e-09 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 1.232e-07 Informative Direct
Molecular Function (MF) lipid binding 5.218e-06 Informative Direct
Molecular Function (MF) purine ribonucleoside binding 3.441e-05 Informative Direct
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) nucleotide binding 0.2322 Informative Inherited
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.008262 Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 0.1489 Informative Inherited
Molecular Function (MF) molecular transducer activity 0.4115 Informative Inherited
Molecular Function (MF) receptor activity 1 Informative Inherited
Molecular Function (MF) ATP binding 1.004e-07 Highly Informative Direct
Molecular Function (MF) small GTPase regulator activity 0.0002386 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0.2176 Highly Informative Inherited
Molecular Function (MF) kinase binding 0.5046 Highly Informative Inherited
Molecular Function (MF) protein binding transcription factor activity 0.01782 Highly Informative Inherited
Molecular Function (MF) Ras GTPase binding 0.4918 Highly Informative Inherited
Molecular Function (MF) tubulin binding 0.001651 Highly Informative Inherited
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0.008964 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.02566 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.0155 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.3908 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 3.132e-15 Moderately Informative Direct
Cellular Component (CC) cytosol 3.774e-06 Moderately Informative Direct
Cellular Component (CC) vesicle 0.06545 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) cell leading edge 0 Informative Direct
Cellular Component (CC) cell cortex 2.545e-12 Informative Direct
Cellular Component (CC) nuclear DNA-directed RNA polymerase complex 2.497e-06 Informative Direct
Cellular Component (CC) synapse part 0.0002742 Informative Direct
Cellular Component (CC) coated vesicle 0.0008939 Informative Direct
Cellular Component (CC) neuron projection 0.005285 Informative Inherited
Cellular Component (CC) cell-cell junction 0.00523 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) actin cytoskeleton 0.04457 Informative Inherited
Cellular Component (CC) nucleoplasm part 0.3106 Informative Inherited
Cellular Component (CC) cell body 1.206e-14 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 2.02e-12 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 1.052e-11 Highly Informative Direct
Cellular Component (CC) contractile ring 4.432e-09 Highly Informative Direct
Cellular Component (CC) ruffle 1.746e-07 Highly Informative Direct
Cellular Component (CC) cell division site part 3.076e-07 Highly Informative Direct
Cellular Component (CC) clathrin-coated vesicle 9.537e-05 Highly Informative Direct
Cellular Component (CC) spindle 0.0003274 Highly Informative Direct
Cellular Component (CC) dendrite 0.5015 Highly Informative Inherited
Cellular Component (CC) apical junction complex 0.07037 Highly Informative Inherited
Cellular Component (CC) centrosome 0.1925 Highly Informative Inherited
Cellular Component (CC) cortical cytoskeleton 0.009721 Highly Informative Inherited
Cellular Component (CC) transcription factor complex 0.003276 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0.0007862Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0.7416Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor7.101e-06InformativeDirect
Enzyme Commission (EC)Diacylglycerol kinase0Highly InformativeDirect
Enzyme Commission (EC)Protein kinase C0Highly InformativeDirect
Enzyme Commission (EC)Protein-disulfide reductase4.229e-11Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.4046Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of head and neck0.5172Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.7243Least InformativeInherited
Phenotypic Abnormality (PA)Generalized abnormality of skin0.3381Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the neck0.02422InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hair0.1139InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin morphology0.1396InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vertebral column0.1721InformativeInherited
Phenotypic Abnormality (PA)Webbed neck0.000192Highly InformativeDirect
Phenotypic Abnormality (PA)Low posterior hairline0.0002279Highly InformativeDirect
Phenotypic Abnormality (PA)Irregular hyperpigmentation0.0006283Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the spinal cord0.003926Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.00407Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.01704Least InformativeInherited
Mammalian Phenotype (MP)abnormal leukopoiesis0.1212Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lymphocyte morphology0.1703Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal T cell morphology0.9542InformativeInherited
Mammalian Phenotype (MP)abnormal T cell selection0.01128Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant1.332e-05Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.000145Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.427Least InformativeInherited
Worm Phenotype (WP)chemical response variant0.03891Moderately InformativeInherited
Worm Phenotype (WP)pattern of transgene expression variant0.09207Moderately InformativeInherited
Worm Phenotype (WP)germ cell morphology variant0.2026Moderately InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant0.2254Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.3357Moderately InformativeInherited
Worm Phenotype (WP)organism pathogen response variant4.936e-06InformativeDirect
Worm Phenotype (WP)chemotaxis variant0.0003274InformativeDirect
Worm Phenotype (WP)cell stress response variant0.01106InformativeInherited
Worm Phenotype (WP)protein expression variant0.05202InformativeInherited
Worm Phenotype (WP)rachis morphology variant0.6657InformativeInherited
Worm Phenotype (WP)drug induced gene expression variant7.02e-10Highly InformativeDirect
Worm Phenotype (WP)response to injury variant1.358e-07Highly InformativeDirect
Worm Phenotype (WP)odorant positive chemotaxis variant2.889e-06Highly InformativeDirect
Worm Phenotype (WP)isothermal tracking behavior variant1.285e-05Highly InformativeDirect
Worm Phenotype (WP)pharyngeal pumping variant1.575e-05Highly InformativeDirect
Worm Phenotype (WP)protein subcellular localization variant4.394e-05Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0.1917Least InformativeInherited
Plant ANatomical entity (PAN)root epidermis7.751e-06InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0.7811Moderately InformativeInherited
Enzyme Commission (EC)Acting on a sulfur group of donors0.0007678InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0.4145InformativeInherited
Enzyme Commission (EC)Diacylglycerol kinase (ATP)0Highly InformativeDirect
Enzyme Commission (EC)Protein kinase C0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor6.988e-06Highly InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase7.958e-05Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0Moderately InformativeDirect
Biological processDifferentiation0Moderately InformativeDirect
Biological processCell cycle2.867e-06Moderately InformativeDirect
Biological processAngiogenesis2.086e-15InformativeDirect
Biological processInflammatory response1.324e-12InformativeDirect
Biological processCell adhesion8.192e-10InformativeDirect
Biological processNeurogenesis7.053e-09InformativeDirect
Biological processBiological rhythms1.149e-06InformativeDirect
Biological processMitosis0.0006982InformativeDirect
Biological processExocytosis8.68e-15Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentNucleus8.123e-13Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentGolgi apparatus6.299e-15Moderately InformativeDirect
Cellular componentCell projection4.534e-12Moderately InformativeDirect
Cellular componentEndosome1.726e-05Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.0002411Moderately InformativeDirect
Cellular componentCell membrane0.0005598Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.0009614Moderately InformativeDirect
Cellular componentMicrotubule8.11e-09InformativeDirect
Cellular componentSynapse0.583InformativeInherited
Cellular componentSynaptosome2.697e-05Highly InformativeDirect
DiseaseProto-oncogene1.476e-15Moderately InformativeDirect
DiseaseTumor suppressor9.919e-06Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainZinc-finger0Moderately InformativeDirect
DomainSH2 domain3.529e-05InformativeDirect
DomainSH3 domain7.534e-05InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionNucleotide-binding9.242e-16Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationDevelopmental protein1.531e-05Moderately InformativeDirect
Post-translational modificationGTPase activation0InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationChromatin regulator0.0001035InformativeDirect
Post-translational modificationMyosin1.824e-08Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cysteine-rich domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the Cysteine-rich domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]