SUPERFAMILY 1.75 HMM library and genome assignments server


RING/U-box superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   RING/U-box [ 57849]
Superfamily:   RING/U-box [ 57850] (6)
Families:   RING finger domain, C3HC4 [ 57851] (14)
  U-box [ 90222] (4)
  Variant RING domain [ 118300] (2)
  IBR domain [ 144228]
  Zf-UBP [ 161204] (3)
  ZZ domain [ 161211] (3)


Superfamily statistics
Genomes (677) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 108,014 0 32
Proteins 96,574 0 32


Functional annotation
General category Information
Detailed category DNA replication/repair

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular macromolecule metabolic process1.569e-100Least InformativeDirect
Biological Process (BP)protein metabolic process5.488e-080Least InformativeDirect
Biological Process (BP)regulation of metabolic process0.24510.003584Least InformativeInherited
Biological Process (BP)regulation of cellular process0.0003680.1244Least InformativeInherited
Biological Process (BP)response to stimulus0.72060.03043Least InformativeInherited
Biological Process (BP)single-organism cellular process0.34770.9456Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.0067480.006468Least InformativeInherited
Biological Process (BP)organelle organization0.00012592.856e-13Moderately InformativeDirect
Biological Process (BP)positive regulation of molecular function0.0020440.1273Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.012660Moderately InformativeInherited
Biological Process (BP)homeostatic process0.044540.9419Moderately InformativeInherited
Biological Process (BP)regulation of catalytic activity0.18311Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.056967.281e-15Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.061261.955e-11Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.06884.56e-09Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.12071Moderately InformativeInherited
Biological Process (BP)signal transduction0.60551Moderately InformativeInherited
Biological Process (BP)protein modification by small protein conjugation or removal7.765e-130InformativeDirect
Biological Process (BP)protein catabolic process3.061e-050InformativeDirect
Biological Process (BP)regulation of peptidase activity0.00014170.0005021InformativeDirect
Biological Process (BP)cellular macromolecule catabolic process0.00025820InformativeDirect
Biological Process (BP)positive regulation of hydrolase activity0.011521InformativeInherited
Biological Process (BP)proteolysis0.0043497.06e-13InformativeInherited
Biological Process (BP)programmed cell death0.00019471InformativeInherited
Biological Process (BP)response to oxidative stress0.0029771InformativeInherited
Biological Process (BP)intracellular signal transduction0.012160.7192InformativeInherited
Biological Process (BP)regulation of cysteine-type endopeptidase activity2.573e-063.444e-07Highly InformativeDirect
Biological Process (BP)positive regulation of peptidase activity4.272e-070.003965Highly InformativeInherited
Biological Process (BP)intrinsic apoptotic signaling pathway2.573e-060.0231Highly InformativeInherited
Molecular Function (MF)binding0.00069530Least InformativeDirect
Molecular Function (MF)ligase activity, forming carbon-nitrogen bonds00InformativeDirect
Molecular Function (MF)small conjugating protein ligase activity00Highly InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.00010330.7854Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.22390.03281Least InformativeInherited
Cellular Component (CC)protein complex2.236e-070.2533Least InformativeInherited
Cellular Component (CC)intracellular organelle lumen0.11930.5614Moderately InformativeInherited
Cellular Component (CC)nuclear part0.0023235.197e-10Moderately InformativeInherited
Cellular Component (CC)ubiquitin ligase complex00InformativeDirect
Cellular Component (CC)nucleoplasm part0.37670.1981InformativeInherited
Cellular Component (CC)nuclear ubiquitin ligase complex2.85e-090Highly InformativeDirect
Cellular Component (CC)nuclear body7.245e-062.18e-13Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular macromolecule metabolic process 0 Least Informative Direct
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.003584 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.006468 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.1244 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.9456 Least Informative Inherited
Biological Process (BP) response to stimulus 0.03043 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) organelle organization 2.856e-13 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 9.885e-05 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 7.281e-15 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 1.955e-11 Moderately Informative Direct
Biological Process (BP) cellular response to stress 4.56e-09 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 4.342e-08 Moderately Informative Direct
Biological Process (BP) immune system process 7.661e-12 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.4138 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.5306 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.8606 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.02864 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.0601 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.008033 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.3551 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.0808 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.9419 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.9714 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.1273 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.2921 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.002315 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 0.2516 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.03767 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.8792 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.01412 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) protein modification by small protein conjugation or removal 0 Informative Direct
Biological Process (BP) protein catabolic process 0 Informative Direct
Biological Process (BP) regulation of peptidase activity 0.0005021 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0 Informative Direct
Biological Process (BP) chromosome organization 1.077e-14 Informative Direct
Biological Process (BP) proteolysis 7.06e-13 Informative Direct
Biological Process (BP) cell cycle process 0.000125 Informative Direct
Biological Process (BP) regulation of organelle organization 4.081e-05 Informative Direct
Biological Process (BP) immune response 6.044e-12 Informative Direct
Biological Process (BP) regulation of response to stress 1.316e-05 Informative Direct
Biological Process (BP) response to DNA damage stimulus 1.347e-05 Informative Direct
Biological Process (BP) protein complex assembly 7.656e-05 Informative Direct
Biological Process (BP) posttranscriptional regulation of gene expression 0.0003554 Informative Direct
Biological Process (BP) regulation of intracellular protein kinase cascade 0.000521 Informative Direct
Biological Process (BP) regulation of apoptotic process 1 Informative Inherited
Biological Process (BP) programmed cell death 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.7161 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.3214 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.9514 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 1 Informative Inherited
Biological Process (BP) positive regulation of developmental process 1 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.496 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 1 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of cell death 1 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.9507 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.003444 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.00446 Informative Inherited
Biological Process (BP) microtubule-based process 0.8772 Informative Inherited
Biological Process (BP) cytoskeleton organization 1 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 1 Informative Inherited
Biological Process (BP) polysaccharide metabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.1487 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.3096 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 0.7572 Informative Inherited
Biological Process (BP) regulation of secretion 1 Informative Inherited
Biological Process (BP) secretion by cell 0.9213 Informative Inherited
Biological Process (BP) regulation of locomotion 0.9034 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.02892 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.6318 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.04462 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.4345 Informative Inherited
Biological Process (BP) regulation of cell development 0.772 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.1692 Informative Inherited
Biological Process (BP) carbohydrate biosynthetic process 0.697 Informative Inherited
Biological Process (BP) transmission of nerve impulse 1 Informative Inherited
Biological Process (BP) cell-cell signaling 1 Informative Inherited
Biological Process (BP) transmembrane transport 1 Informative Inherited
Biological Process (BP) DNA metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.03315 Informative Inherited
Biological Process (BP) generation of neurons 0.9582 Informative Inherited
Biological Process (BP) sensory organ development 1 Informative Inherited
Biological Process (BP) organ morphogenesis 1 Informative Inherited
Biological Process (BP) cellular membrane organization 1 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 1 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.002812 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.02432 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.3777 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) muscle structure development 0.4452 Informative Inherited
Biological Process (BP) muscle tissue development 1 Informative Inherited
Biological Process (BP) ncRNA metabolic process 1 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.9582 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.8755 Informative Inherited
Biological Process (BP) response to other organism 0.6037 Informative Inherited
Biological Process (BP) response to oxidative stress 1 Informative Inherited
Biological Process (BP) epithelium development 0.2272 Informative Inherited
Biological Process (BP) positive regulation of protein modification process 1 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.7192 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.3884 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 1 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 1 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.8938 Informative Inherited
Biological Process (BP) phosphorylation 1 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.2313 Informative Inherited
Biological Process (BP) protein localization to organelle 0.02216 Informative Inherited
Biological Process (BP) protein transport 0.002026 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.4079 Informative Inherited
Biological Process (BP) immune effector process 0.0186 Informative Inherited
Biological Process (BP) defense response 0.3685 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.244 Informative Inherited
Biological Process (BP) leukocyte activation 0.9301 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.1513 Informative Inherited
Biological Process (BP) regulation of immune response 0.4704 Informative Inherited
Biological Process (BP) response to wounding 1 Informative Inherited
Biological Process (BP) mitochondrion organization 1 Informative Inherited
Biological Process (BP) regulation of cysteine-type endopeptidase activity 3.444e-07 Highly Informative Direct
Biological Process (BP) protein ubiquitination 0 Highly Informative Direct
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 0 Highly Informative Direct
Biological Process (BP) regulation of multi-organism process 0 Highly Informative Direct
Biological Process (BP) internal protein amino acid acetylation 3.981e-12 Highly Informative Direct
Biological Process (BP) regulation of protein catabolic process 4.249e-12 Highly Informative Direct
Biological Process (BP) regulation of protein ubiquitination 2.829e-11 Highly Informative Direct
Biological Process (BP) regulation of protein stability 4.898e-11 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 8.322e-10 Highly Informative Direct
Biological Process (BP) regulation of innate immune response 1.136e-09 Highly Informative Direct
Biological Process (BP) peptidyl-lysine modification 3.121e-09 Highly Informative Direct
Biological Process (BP) immune response-regulating signaling pathway 1.266e-07 Highly Informative Direct
Biological Process (BP) regulation of ligase activity 2.557e-07 Highly Informative Direct
Biological Process (BP) DNA recombination 2.929e-07 Highly Informative Direct
Biological Process (BP) leukocyte activation involved in immune response 4.423e-07 Highly Informative Direct
Biological Process (BP) response to ionizing radiation 9.103e-07 Highly Informative Direct
Biological Process (BP) positive regulation of catabolic process 1.002e-06 Highly Informative Direct
Biological Process (BP) protein import 2.343e-06 Highly Informative Direct
Biological Process (BP) B cell activation 8.887e-06 Highly Informative Direct
Biological Process (BP) response to topologically incorrect protein 2.25e-05 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic signaling pathway 4.894e-05 Highly Informative Direct
Biological Process (BP) regulation of proteolysis 4.944e-05 Highly Informative Direct
Biological Process (BP) regulation of autophagy 0.0001369 Highly Informative Direct
Biological Process (BP) positive regulation of defense response 0.0001841 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 0.0006362 Highly Informative Direct
Biological Process (BP) regulation of gene expression, epigenetic 0.0009814 Highly Informative Direct
Biological Process (BP) negative regulation of endopeptidase activity 0.794 Highly Informative Inherited
Biological Process (BP) positive regulation of peptidase activity 0.003965 Highly Informative Inherited
Biological Process (BP) aging 0.1339 Highly Informative Inherited
Biological Process (BP) regulation of mitochondrion organization 0.1811 Highly Informative Inherited
Biological Process (BP) cell wall biogenesis 0.006559 Highly Informative Inherited
Biological Process (BP) cellular component macromolecule biosynthetic process 0.007571 Highly Informative Inherited
Biological Process (BP) cell wall macromolecule metabolic process 1 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 1 Highly Informative Inherited
Biological Process (BP) glial cell differentiation 0.1984 Highly Informative Inherited
Biological Process (BP) regulation of mitosis 0.006255 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular catabolic process 0.1833 Highly Informative Inherited
Biological Process (BP) negative regulation of mitotic cell cycle phase transition 0.2224 Highly Informative Inherited
Biological Process (BP) negative regulation of cell cycle 1 Highly Informative Inherited
Biological Process (BP) modification of morphology or physiology of other organism 0.1187 Highly Informative Inherited
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.497 Highly Informative Inherited
Biological Process (BP) negative regulation of protein modification process 0.535 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 0.1432 Highly Informative Inherited
Biological Process (BP) cellular polysaccharide biosynthetic process 0.02521 Highly Informative Inherited
Biological Process (BP) regulation of production of molecular mediator of immune response 0.5521 Highly Informative Inherited
Biological Process (BP) negative regulation of locomotion 0.3569 Highly Informative Inherited
Biological Process (BP) regulation of cellular ketone metabolic process 0.1146 Highly Informative Inherited
Biological Process (BP) negative regulation of lipid biosynthetic process 0.001442 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.4533 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.9312 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 1 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.9015 Highly Informative Inherited
Biological Process (BP) photoreceptor cell differentiation 0.3133 Highly Informative Inherited
Biological Process (BP) DNA damage checkpoint 1 Highly Informative Inherited
Biological Process (BP) DNA modification 0.9691 Highly Informative Inherited
Biological Process (BP) leukocyte homeostasis 0.239 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.779 Highly Informative Inherited
Biological Process (BP) cell fate commitment 1 Highly Informative Inherited
Biological Process (BP) leukocyte mediated immunity 0.6702 Highly Informative Inherited
Biological Process (BP) innate immune response 0.001058 Highly Informative Inherited
Biological Process (BP) cellular membrane fusion 0.4235 Highly Informative Inherited
Biological Process (BP) regulation of protein complex assembly 0.3668 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.2141 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 0.1195 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.1667 Highly Informative Inherited
Biological Process (BP) regulation of protein depolymerization 0.4 Highly Informative Inherited
Biological Process (BP) ubiquitin-dependent protein catabolic process 1 Highly Informative Inherited
Biological Process (BP) nucleus organization 0.5378 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.3068 Highly Informative Inherited
Biological Process (BP) regulation of translation 0.1506 Highly Informative Inherited
Biological Process (BP) histone modification 0.9666 Highly Informative Inherited
Biological Process (BP) establishment of protein localization to organelle 0.00931 Highly Informative Inherited
Biological Process (BP) regulation of angiogenesis 0.02718 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.1523 Highly Informative Inherited
Biological Process (BP) cellular hormone metabolic process 0.998 Highly Informative Inherited
Biological Process (BP) intrinsic apoptotic signaling pathway 0.0231 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.01164 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 0.2843 Highly Informative Inherited
Biological Process (BP) protein phosphorylation 1 Highly Informative Inherited
Biological Process (BP) regulation of microtubule polymerization or depolymerization 0.4245 Highly Informative Inherited
Biological Process (BP) negative regulation of cytoskeleton organization 0.04142 Highly Informative Inherited
Biological Process (BP) negative regulation of protein complex disassembly 0.05147 Highly Informative Inherited
Biological Process (BP) protein deacylation 1 Highly Informative Inherited
Biological Process (BP) T cell differentiation 0.01578 Highly Informative Inherited
Biological Process (BP) alpha-beta T cell activation 0.07831 Highly Informative Inherited
Biological Process (BP) activation of immune response 0.002464 Highly Informative Inherited
Biological Process (BP) plasma membrane organization 0.4644 Highly Informative Inherited
Biological Process (BP) wound healing 1 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) cation binding 5.424e-08 Moderately Informative Direct
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 0 Informative Direct
Molecular Function (MF) transition metal ion binding 0 Informative Direct
Molecular Function (MF) chromatin binding 3.737e-06 Informative Direct
Molecular Function (MF) enzyme binding 0.0007168 Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.5927 Informative Inherited
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) RNA binding 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 0.4998 Informative Inherited
Molecular Function (MF) nucleotide binding 1 Informative Inherited
Molecular Function (MF) receptor activity 1 Informative Inherited
Molecular Function (MF) molecular transducer activity 1 Informative Inherited
Molecular Function (MF) DNA binding 0.7264 Informative Inherited
Molecular Function (MF) peptidase activity 0.09167 Informative Inherited
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0.9155 Informative Inherited
Molecular Function (MF) carboxylic acid binding 0.7274 Informative Inherited
Molecular Function (MF) lipid binding 1 Informative Inherited
Molecular Function (MF) small conjugating protein ligase activity 0 Highly Informative Direct
Molecular Function (MF) thiolester hydrolase activity 0 Highly Informative Direct
Molecular Function (MF) protein binding transcription factor activity 8.89e-06 Highly Informative Direct
Molecular Function (MF) deacetylase activity 0.0001038 Highly Informative Direct
Molecular Function (MF) acetyltransferase activity 0.0006652 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.001528 Highly Informative Inherited
Molecular Function (MF) structure-specific DNA binding 0.3944 Highly Informative Inherited
Molecular Function (MF) cytokine receptor binding 1 Highly Informative Inherited
Molecular Function (MF) endopeptidase activity 0.212 Highly Informative Inherited
Molecular Function (MF) amino acid binding 0.1545 Highly Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1.328e-07 Least Informative Direct
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.7854 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.03281 Least Informative Inherited
Cellular Component (CC) protein complex 0.2533 Least Informative Inherited
Cellular Component (CC) nuclear part 5.197e-10 Moderately Informative Direct
Cellular Component (CC) ribonucleoprotein complex 0.5143 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 1 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 1 Moderately Informative Inherited
Cellular Component (CC) mitochondrial part 1 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 1 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.0441 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.5614 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 0 Informative Direct
Cellular Component (CC) chromosome 1.529e-09 Informative Direct
Cellular Component (CC) endosome 9.547e-05 Informative Direct
Cellular Component (CC) lytic vacuole 0.1852 Informative Inherited
Cellular Component (CC) integral to membrane 1 Informative Inherited
Cellular Component (CC) intrinsic to plasma membrane 1 Informative Inherited
Cellular Component (CC) actin cytoskeleton 1 Informative Inherited
Cellular Component (CC) microbody 0.001488 Informative Inherited
Cellular Component (CC) mitochondrial membrane part 1 Informative Inherited
Cellular Component (CC) vacuolar part 0.003692 Informative Inherited
Cellular Component (CC) contractile fiber part 0.2223 Informative Inherited
Cellular Component (CC) nuclear DNA-directed RNA polymerase complex 1 Informative Inherited
Cellular Component (CC) nucleoplasm part 0.1981 Informative Inherited
Cellular Component (CC) nuclear ubiquitin ligase complex 0 Highly Informative Direct
Cellular Component (CC) nuclear body 2.18e-13 Highly Informative Direct
Cellular Component (CC) cytoplasmic mRNA processing body 0 Highly Informative Direct
Cellular Component (CC) sarcolemma 4.66e-11 Highly Informative Direct
Cellular Component (CC) microbody membrane 7.175e-11 Highly Informative Direct
Cellular Component (CC) microbody part 2.352e-07 Highly Informative Direct
Cellular Component (CC) internal side of plasma membrane 1.219e-05 Highly Informative Direct
Cellular Component (CC) intrinsic to organelle membrane 0.0001013 Highly Informative Direct
Cellular Component (CC) CCR4-NOT complex 0.0001448 Highly Informative Direct
Cellular Component (CC) lysosome 0.2841 Highly Informative Inherited
Cellular Component (CC) receptor complex 1 Highly Informative Inherited
Cellular Component (CC) integral to plasma membrane 1 Highly Informative Inherited
Cellular Component (CC) endosomal part 0.08982 Highly Informative Inherited
Cellular Component (CC) myosin complex 0.6685 Highly Informative Inherited
Cellular Component (CC) organelle outer membrane 0.1724 Highly Informative Inherited
Cellular Component (CC) condensed chromosome 0.6947 Highly Informative Inherited
Cellular Component (CC) myofilament 0.09409 Highly Informative Inherited
Cellular Component (CC) sarcomere 0.7574 Highly Informative Inherited
Cellular Component (CC) transcription factor complex 1 Highly Informative Inherited
Cellular Component (CC) chromatin 0.7228 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Isomerases0.0228Least InformativeInherited
Enzyme Commission (EC)Omega peptidases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases1.652e-09Moderately InformativeDirect
Enzyme Commission (EC)Transferring groups other than amino-acyl groups4.836e-06Moderately InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect
Enzyme Commission (EC)Peptidylprolyl isomerase6.579e-13InformativeDirect
Enzyme Commission (EC)Cellulose synthase (UDP-forming)0Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of muscle physiology0.6217Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the globe0.7699Moderately InformativeInherited
Phenotypic Abnormality (PA)Muscular hypotonia0.3262InformativeInherited
Phenotypic Abnormality (PA)Generalized neonatal hypotonia8.193e-06Highly InformativeDirect
Phenotypic Abnormality (PA)Brushfield spots0.0001523Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.05067Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.8035Least InformativeInherited
Mammalian Phenotype (MP)abnormal tumor incidence0.005338Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.0259Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin secretion0.619InformativeInherited
Mammalian Phenotype (MP)chromosomal instability2.87e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal interleukin-2 secretion0.0413Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant1.122e-15Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.5632Least InformativeInherited
Worm Phenotype (WP)protein aggregation variant0Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant2.914e-09Moderately InformativeDirect
Worm Phenotype (WP)cell homeostasis metabolism variant0.00099Moderately InformativeDirect
Worm Phenotype (WP)cell stress response variant7.14e-09InformativeDirect
Worm Phenotype (WP)neuron development variant0.2742InformativeInherited
Worm Phenotype (WP)cell ionizing radiation response variant4.226e-08Highly InformativeDirect
Worm Phenotype (WP)axon morphology variant0.1107Highly InformativeInherited
Worm Phenotype (WP)germ cell ionizing radiation response variant0.1541Highly InformativeInherited

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)gonad0.001829Least InformativeInherited
Xenopus ANatomical entity (XAN)genital system0.002268Least InformativeInherited
Xenopus ANatomical entity (XAN)ovary0.0006058Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)leaf0.6547Least InformativeInherited
Plant ANatomical entity (PAN)pollen tube cell9.658e-05InformativeDirect
Plant ANatomical entity (PAN)leaf epidermis0.0001737Highly InformativeDirect
Plant ANatomical entity (PAN)trichome0.005802Highly InformativeInherited
Plant structure DEvelopment stage (PDE)pollen development stage1.142e-05Moderately InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases1.907e-15Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases8.514e-09Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases8.84e-05Moderately InformativeDirect
Enzyme Commission (EC)Isomerases0.03104Moderately InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0.08357Moderately InformativeInherited
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds1Moderately InformativeInherited
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect
Enzyme Commission (EC)Hexosyltransferases0InformativeDirect
Enzyme Commission (EC)Omega peptidases0InformativeDirect
Enzyme Commission (EC)In linear amides0.1251InformativeInherited
Enzyme Commission (EC)Acid--amino-acid ligases (peptide synthases)0.2256InformativeInherited
Enzyme Commission (EC)Peptidylprolyl isomerase8.08e-13Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0Moderately InformativeDirect
Biological processTranscription regulation1.554e-12Moderately InformativeDirect
Biological processHost-virus interaction9.714e-12Moderately InformativeDirect
Biological processCell cycle5.086e-10Moderately InformativeDirect
Biological processDNA damage4.605e-06Moderately InformativeDirect
Biological processDifferentiation0.0006415Moderately InformativeDirect
Biological processMitosis0InformativeDirect
Biological processUbl conjugation pathway0InformativeDirect
Biological processEndocytosis2.874e-14InformativeDirect
Biological processWnt signaling pathway7.278e-14InformativeDirect
Biological processmRNA splicing7.702e-10InformativeDirect
Biological processPlant defense6.35e-06InformativeDirect
Biological processMeiosis1.75e-05InformativeDirect
Biological processViral immunoevasion0.03376InformativeInherited
Biological processAntiviral defense0Highly InformativeDirect
Biological processNotch signaling pathway0Highly InformativeDirect
Biological processAutophagy2.686e-13Highly InformativeDirect
Biological processVirus exit from host cell3.745e-06Highly InformativeDirect
Biological processModulation of host cell apoptosis by virus0.000145Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentEndosome0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle7.658e-14Moderately InformativeDirect
Cellular componentGolgi apparatus4.393e-10Moderately InformativeDirect
Cellular componentCell junction1.675e-06Moderately InformativeDirect
Cellular componentMitochondrion1Moderately InformativeInherited
Cellular componentLysosome0InformativeDirect
Cellular componentPeroxisome0InformativeDirect
Cellular componentSpliceosome1.078e-12InformativeDirect
Cellular componentChromosome8.2e-12InformativeDirect
Cellular componentVacuole7.453e-08InformativeDirect
Cellular componentMitochondrion outer membrane1.577e-07InformativeDirect
Cellular componentSynapse1.684e-06InformativeDirect
Cellular componentHost cytoplasm2.459e-05InformativeDirect
Cellular componentLipid droplet1.771e-06Highly InformativeDirect
Cellular componentHost endosome0.0003744Highly InformativeDirect
Coding sequence diversityAlternative splicing1.402e-12Least InformativeDirect
Developmental stageEarly protein0.0001772Least InformativeDirect
DiseaseTumor suppressor9.047e-05Moderately InformativeDirect
DiseaseOsteopetrosis6.619e-08Highly InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainCoiled coil0Moderately InformativeDirect
DomainZinc-finger0Moderately InformativeDirect
DomainBromodomain9.018e-07Highly InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationLigase0Moderately InformativeDirect
Post-translational modificationRepressor0Moderately InformativeDirect
Post-translational modificationDevelopmental protein8.109e-10Moderately InformativeDirect
Post-translational modificationActivator1.163e-05Moderately InformativeDirect
Post-translational modificationProtease0.01436Moderately InformativeInherited
Post-translational modificationChromatin regulator0InformativeDirect
Post-translational modificationThiol protease0InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation9.25e-14Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond8.793e-12Moderately InformativeDirect
Post-translational modificationMyristate0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect
UniPathway (UP)glycan metabolism1Moderately InformativeInherited
UniPathway (UP)cellulose metabolism6.77e-16InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 27 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a RING/U-box domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 27 hidden Markov models representing the RING/U-box superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]