SUPERFAMILY 1.75 HMM library and genome assignments server


RING/U-box superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   RING/U-box [ 57849]
Superfamily:   RING/U-box [ 57850] (6)
Families:   RING finger domain, C3HC4 [ 57851] (14)
  U-box [ 90222] (4)
  Variant RING domain [ 118300] (2)
  IBR domain [ 144228]
  Zf-UBP [ 161204] (3)
  ZZ domain [ 161211] (3)


Superfamily statistics
Genomes (594) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 95,955 83,301 32
Proteins 85,952 75,585 32


Functional annotation
General category Information
Detailed category DNA replication/repair

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular macromolecule metabolic process3.916e-090Least InformativeDirect
Biological Process (BP)protein metabolic process1.904e-070Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis0.011770.01443Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.13450.01681Least InformativeInherited
Biological Process (BP)regulation of cellular process0.0012130.3165Least InformativeInherited
Biological Process (BP)single-organism cellular process0.25381Least InformativeInherited
Biological Process (BP)organelle organization0.00015931.083e-09Moderately InformativeDirect
Biological Process (BP)regulation of molecular function0.15870.102Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.024880Moderately InformativeInherited
Biological Process (BP)homeostatic process0.061631Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.088892.615e-14Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.088352.512e-11Moderately InformativeInherited
Biological Process (BP)protein modification by small protein conjugation or removal8.555e-130InformativeDirect
Biological Process (BP)protein catabolic process6.593e-050InformativeDirect
Biological Process (BP)anatomical structure homeostasis0.0002070.0007011InformativeDirect
Biological Process (BP)cellular macromolecule catabolic process0.00052060InformativeDirect
Biological Process (BP)regulation of mitotic cell cycle0.00017970.004349InformativeInherited
Biological Process (BP)regulation of cell cycle process0.00038160.06844InformativeInherited
Biological Process (BP)regulation of hydrolase activity0.072041InformativeInherited
Biological Process (BP)positive regulation of catalytic activity0.00036051InformativeInherited
Biological Process (BP)proteolysis0.0064992.019e-13InformativeInherited
Biological Process (BP)regulation of apoptotic process6.768e-051InformativeInherited
Biological Process (BP)apoptotic process0.00010080.4753InformativeInherited
Biological Process (BP)modification-dependent protein catabolic process1.833e-091.086e-08Highly InformativeDirect
Biological Process (BP)positive regulation of peptidase activity7.317e-070.003348Highly InformativeInherited
Biological Process (BP)regulation of cysteine-type endopeptidase activity involved in apoptotic process0.0011890.02062Highly InformativeInherited
Molecular Function (MF)ligase activity, forming carbon-nitrogen bonds00InformativeDirect
Molecular Function (MF)small conjugating protein ligase activity00Highly InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.00010491Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.18440.03392Least InformativeInherited
Cellular Component (CC)protein complex1.21e-070.2834Least InformativeInherited
Cellular Component (CC)nuclear part0.00052938.809e-10Moderately InformativeDirect
Cellular Component (CC)intracellular organelle lumen0.053160.7275Moderately InformativeInherited
Cellular Component (CC)ubiquitin ligase complex00InformativeDirect
Cellular Component (CC)nucleoplasm part0.50810.1538InformativeInherited
Cellular Component (CC)nuclear ubiquitin ligase complex9.775e-090Highly InformativeDirect
Cellular Component (CC)nuclear body9.184e-064.594e-14Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular macromolecule metabolic process 0 Least Informative Direct
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) developmental process 0.9529 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.3165 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.01681 Least Informative Inherited
Biological Process (BP) response to stimulus 0.1126 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.01443 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organelle organization 1.083e-09 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 1.14e-05 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 2.512e-11 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 2.615e-14 Moderately Informative Direct
Biological Process (BP) immune system process 6.981e-07 Moderately Informative Direct
Biological Process (BP) cellular response to stress 4.09e-09 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 9.572e-05 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0.0003751 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0.0004736 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0.102 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.2371 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.009748 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.01812 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.8667 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.09662 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.8269 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.8552 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.02094 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.3038 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 0.1254 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.6178 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.9987 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 0.549 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.2351 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.8178 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.002291 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) protein modification by small protein conjugation or removal 0 Informative Direct
Biological Process (BP) protein catabolic process 0 Informative Direct
Biological Process (BP) anatomical structure homeostasis 0.0007011 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0 Informative Direct
Biological Process (BP) chromosome organization 5.43e-14 Informative Direct
Biological Process (BP) proteolysis 2.019e-13 Informative Direct
Biological Process (BP) regulation of organelle organization 9.506e-05 Informative Direct
Biological Process (BP) regulation of response to stress 6.631e-08 Informative Direct
Biological Process (BP) response to DNA damage stimulus 4.62e-06 Informative Direct
Biological Process (BP) posttranscriptional regulation of gene expression 7.642e-05 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.8288 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 1 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 1 Informative Inherited
Biological Process (BP) cell proliferation 0.08728 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.6286 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 0.5358 Informative Inherited
Biological Process (BP) cell cycle process 0.00128 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.002195 Informative Inherited
Biological Process (BP) negative regulation of molecular function 1 Informative Inherited
Biological Process (BP) microtubule-based process 1 Informative Inherited
Biological Process (BP) cytoskeleton organization 1 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 1 Informative Inherited
Biological Process (BP) polysaccharide metabolic process 1 Informative Inherited
Biological Process (BP) regulation of protein localization 0.1042 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.4768 Informative Inherited
Biological Process (BP) regulation of secretion 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.06844 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 0.006815 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.06801 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.2981 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.2552 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.01004 Informative Inherited
Biological Process (BP) regulation of cell development 0.3817 Informative Inherited
Biological Process (BP) carbohydrate biosynthetic process 0.7217 Informative Inherited
Biological Process (BP) sensory organ development 1 Informative Inherited
Biological Process (BP) organ morphogenesis 1 Informative Inherited
Biological Process (BP) synaptic transmission 1 Informative Inherited
Biological Process (BP) transmembrane transport 1 Informative Inherited
Biological Process (BP) DNA metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.1216 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.001699 Informative Inherited
Biological Process (BP) cellular membrane organization 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.9116 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of cellular metabolic process 0.02912 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.004349 Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.3489 Informative Inherited
Biological Process (BP) chordate embryonic development 0.3092 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) response to external stimulus 1 Informative Inherited
Biological Process (BP) muscle structure development 0.6506 Informative Inherited
Biological Process (BP) muscle tissue development 1 Informative Inherited
Biological Process (BP) response to organic nitrogen 0.8319 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.8554 Informative Inherited
Biological Process (BP) response to other organism 0.8481 Informative Inherited
Biological Process (BP) response to inorganic substance 0.6242 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.7514 Informative Inherited
Biological Process (BP) sexual reproduction 0.7894 Informative Inherited
Biological Process (BP) single organism reproductive process 0.8807 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.9269 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 1 Informative Inherited
Biological Process (BP) epithelium development 0.4045 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.8889 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.6876 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 1 Informative Inherited
Biological Process (BP) positive regulation of phosphorus metabolic process 1 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.8746 Informative Inherited
Biological Process (BP) protein phosphorylation 1 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.001236 Informative Inherited
Biological Process (BP) regulation of apoptotic process 1 Informative Inherited
Biological Process (BP) apoptotic process 0.4753 Informative Inherited
Biological Process (BP) pigment metabolic process 0.9718 Informative Inherited
Biological Process (BP) protein localization to organelle 0.04844 Informative Inherited
Biological Process (BP) protein transport 0.05846 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.3576 Informative Inherited
Biological Process (BP) immune effector process 0.05628 Informative Inherited
Biological Process (BP) defense response 1 Informative Inherited
Biological Process (BP) cell activation 0.5353 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.06258 Informative Inherited
Biological Process (BP) regulation of immune response 0.1502 Informative Inherited
Biological Process (BP) immune response 0.001537 Informative Inherited
Biological Process (BP) response to wounding 1 Informative Inherited
Biological Process (BP) mitochondrion organization 1 Informative Inherited
Biological Process (BP) modification-dependent protein catabolic process 1.086e-08 Highly Informative Direct
Biological Process (BP) protein ubiquitination 0 Highly Informative Direct
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 0 Highly Informative Direct
Biological Process (BP) regulation of protein stability 1.482e-11 Highly Informative Direct
Biological Process (BP) regulation of protein ubiquitination 1.521e-10 Highly Informative Direct
Biological Process (BP) regulation of protein catabolic process 1.821e-10 Highly Informative Direct
Biological Process (BP) regulation of innate immune response 2.539e-10 Highly Informative Direct
Biological Process (BP) internal protein amino acid acetylation 3.361e-10 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 4.42e-10 Highly Informative Direct
Biological Process (BP) immune response-regulating signaling pathway 6.423e-09 Highly Informative Direct
Biological Process (BP) regulation of multi-organism process 2.298e-08 Highly Informative Direct
Biological Process (BP) peptidyl-lysine modification 5.017e-08 Highly Informative Direct
Biological Process (BP) B cell activation 6.821e-08 Highly Informative Direct
Biological Process (BP) regulation of ligase activity 2.361e-07 Highly Informative Direct
Biological Process (BP) DNA recombination 3.621e-07 Highly Informative Direct
Biological Process (BP) response to ionizing radiation 4.853e-07 Highly Informative Direct
Biological Process (BP) response to topologically incorrect protein 1.653e-05 Highly Informative Direct
Biological Process (BP) activation of immune response 1.849e-05 Highly Informative Direct
Biological Process (BP) negative regulation of lipid biosynthetic process 0.0001827 Highly Informative Direct
Biological Process (BP) protein import 0.000189 Highly Informative Direct
Biological Process (BP) leukocyte activation involved in immune response 0.0002394 Highly Informative Direct
Biological Process (BP) stem cell proliferation 0.0002814 Highly Informative Direct
Biological Process (BP) regulation of proteolysis 0.0004445 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 0.000499 Highly Informative Direct
Biological Process (BP) DNA methylation or demethylation 0.0005148 Highly Informative Direct
Biological Process (BP) hormone-mediated signaling pathway 0.0005419 Highly Informative Direct
Biological Process (BP) positive regulation of peptidase activity 0.003348 Highly Informative Inherited
Biological Process (BP) aging 0.08835 Highly Informative Inherited
Biological Process (BP) regulation of mitochondrion organization 0.1618 Highly Informative Inherited
Biological Process (BP) cell wall biogenesis 0.00906 Highly Informative Inherited
Biological Process (BP) cellular component macromolecule biosynthetic process 0.01138 Highly Informative Inherited
Biological Process (BP) cell wall macromolecule metabolic process 1 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 1 Highly Informative Inherited
Biological Process (BP) glial cell differentiation 0.1285 Highly Informative Inherited
Biological Process (BP) mitotic cell cycle 0.7767 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular catabolic process 0.2692 Highly Informative Inherited
Biological Process (BP) negative regulation of cell cycle 0.8946 Highly Informative Inherited
Biological Process (BP) negative regulation of protein modification process 0.4075 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 0.4619 Highly Informative Inherited
Biological Process (BP) cellular glucan metabolic process 0.5244 Highly Informative Inherited
Biological Process (BP) regulation of protein secretion 0.4746 Highly Informative Inherited
Biological Process (BP) regulation of cellular ketone metabolic process 0.04385 Highly Informative Inherited
Biological Process (BP) regulation of neuron differentiation 0.6619 Highly Informative Inherited
Biological Process (BP) regulation of lymphocyte activation 0.6148 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.9766 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.8773 Highly Informative Inherited
Biological Process (BP) photoreceptor cell differentiation 0.5367 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 1 Highly Informative Inherited
Biological Process (BP) cellular membrane fusion 0.2182 Highly Informative Inherited
Biological Process (BP) negative regulation of signal transduction 1 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular macromolecule biosynthetic process 0.4407 Highly Informative Inherited
Biological Process (BP) negative regulation of gene expression 1 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.7323 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 0.12 Highly Informative Inherited
Biological Process (BP) nucleus organization 0.3896 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.2582 Highly Informative Inherited
Biological Process (BP) regulation of translation 0.01456 Highly Informative Inherited
Biological Process (BP) histone modification 0.8372 Highly Informative Inherited
Biological Process (BP) regulation of angiogenesis 0.01615 Highly Informative Inherited
Biological Process (BP) autophagy 0.09647 Highly Informative Inherited
Biological Process (BP) cellular response to starvation 1 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.2142 Highly Informative Inherited
Biological Process (BP) regulation of gene expression, epigenetic 0.005774 Highly Informative Inherited
Biological Process (BP) secondary metabolite biosynthetic process 0.3912 Highly Informative Inherited
Biological Process (BP) spermatogenesis 0.0106 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.003536 Highly Informative Inherited
Biological Process (BP) germ cell development 0.01176 Highly Informative Inherited
Biological Process (BP) activation of protein kinase activity 0.09118 Highly Informative Inherited
Biological Process (BP) positive regulation of protein serine/threonine kinase activity 0.1221 Highly Informative Inherited
Biological Process (BP) regulation of protein complex disassembly 0.02009 Highly Informative Inherited
Biological Process (BP) regulation of microtubule polymerization or depolymerization 0.1947 Highly Informative Inherited
Biological Process (BP) negative regulation of cytoskeleton organization 0.03757 Highly Informative Inherited
Biological Process (BP) regulation of cysteine-type endopeptidase activity involved in apoptotic process 0.02062 Highly Informative Inherited
Biological Process (BP) pigment biosynthetic process 0.9198 Highly Informative Inherited
Biological Process (BP) lipoprotein metabolic process 1 Highly Informative Inherited
Biological Process (BP) protein deacylation 1 Highly Informative Inherited
Biological Process (BP) DNA repair 0.04366 Highly Informative Inherited
Biological Process (BP) leukocyte mediated immunity 0.8673 Highly Informative Inherited
Biological Process (BP) plasma membrane organization 0.2448 Highly Informative Inherited
Biological Process (BP) wound healing 1 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) protein binding 0 Moderately Informative Direct
Molecular Function (MF) cation binding 2.944e-09 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) heterocyclic compound binding 1 Moderately Informative Inherited
Molecular Function (MF) organic cyclic compound binding 1 Moderately Informative Inherited
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 0 Informative Direct
Molecular Function (MF) transition metal ion binding 0 Informative Direct
Molecular Function (MF) enzyme binding 0.0003213 Informative Direct
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) RNA binding 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 0.8128 Informative Inherited
Molecular Function (MF) nucleotide binding 1 Informative Inherited
Molecular Function (MF) molecular transducer activity 1 Informative Inherited
Molecular Function (MF) receptor activity 1 Informative Inherited
Molecular Function (MF) DNA binding 0.8075 Informative Inherited
Molecular Function (MF) peptidase activity 0.2877 Informative Inherited
Molecular Function (MF) carboxylic acid binding 0.7156 Informative Inherited
Molecular Function (MF) lipid binding 1 Informative Inherited
Molecular Function (MF) small conjugating protein ligase activity 0 Highly Informative Direct
Molecular Function (MF) thiolester hydrolase activity 0 Highly Informative Direct
Molecular Function (MF) zinc ion binding 0 Highly Informative Direct
Molecular Function (MF) chromatin binding 4.453e-07 Highly Informative Direct
Molecular Function (MF) deacetylase activity 0.0005495 Highly Informative Direct
Molecular Function (MF) structure-specific DNA binding 0.2229 Highly Informative Inherited
Molecular Function (MF) acetyltransferase activity 0.00484 Highly Informative Inherited
Molecular Function (MF) endopeptidase activity 0.3449 Highly Informative Inherited
Molecular Function (MF) transcription factor binding transcription factor activity 0.3784 Highly Informative Inherited
Molecular Function (MF) modified amino acid binding 0.005727 Highly Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1.358e-06 Least Informative Direct
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.03392 Least Informative Inherited
Cellular Component (CC) protein complex 0.2834 Least Informative Inherited
Cellular Component (CC) nuclear part 8.809e-10 Moderately Informative Direct
Cellular Component (CC) ribonucleoprotein complex 0.2871 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 1 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 1 Moderately Informative Inherited
Cellular Component (CC) mitochondrial part 1 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 1 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.159 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.7275 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 0 Informative Direct
Cellular Component (CC) chromosome 4.28e-07 Informative Direct
Cellular Component (CC) vacuole 0.0001617 Informative Direct
Cellular Component (CC) microbody 0.0002043 Informative Direct
Cellular Component (CC) integral to membrane 1 Informative Inherited
Cellular Component (CC) intrinsic to plasma membrane 1 Informative Inherited
Cellular Component (CC) actin cytoskeleton 1 Informative Inherited
Cellular Component (CC) mitochondrial membrane part 1 Informative Inherited
Cellular Component (CC) contractile fiber part 0.2535 Informative Inherited
Cellular Component (CC) DNA-directed RNA polymerase complex 0.4112 Informative Inherited
Cellular Component (CC) nucleoplasm part 0.1538 Informative Inherited
Cellular Component (CC) nuclear ubiquitin ligase complex 0 Highly Informative Direct
Cellular Component (CC) nuclear body 4.594e-14 Highly Informative Direct
Cellular Component (CC) cytoplasmic mRNA processing body 0 Highly Informative Direct
Cellular Component (CC) sarcolemma 1.475e-11 Highly Informative Direct
Cellular Component (CC) microbody membrane 1.536e-11 Highly Informative Direct
Cellular Component (CC) microbody part 1.239e-07 Highly Informative Direct
Cellular Component (CC) integral to organelle membrane 4.187e-06 Highly Informative Direct
Cellular Component (CC) internal side of plasma membrane 4.719e-05 Highly Informative Direct
Cellular Component (CC) CCR4-NOT complex 6.309e-05 Highly Informative Direct
Cellular Component (CC) receptor complex 1 Highly Informative Inherited
Cellular Component (CC) integral to plasma membrane 1 Highly Informative Inherited
Cellular Component (CC) myosin complex 0.6636 Highly Informative Inherited
Cellular Component (CC) mitochondrial outer membrane 0.01904 Highly Informative Inherited
Cellular Component (CC) condensed chromosome 0.6803 Highly Informative Inherited
Cellular Component (CC) vacuolar membrane 0.0106 Highly Informative Inherited
Cellular Component (CC) sarcomere 0.8198 Highly Informative Inherited
Cellular Component (CC) transcription factor complex 1 Highly Informative Inherited
Cellular Component (CC) chromatin 0.8156 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Isomerases0.0228Least InformativeInherited
Enzyme Commission (EC)Omega peptidases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases1.652e-09Moderately InformativeDirect
Enzyme Commission (EC)Transferring groups other than amino-acyl groups4.836e-06Moderately InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect
Enzyme Commission (EC)Peptidylprolyl isomerase6.579e-13InformativeDirect
Enzyme Commission (EC)Cellulose synthase (UDP-forming)0Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the anterior segment of the eye0.2274Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle physiology0.4036Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of prenatal development or birth0.02131InformativeInherited
Phenotypic Abnormality (PA)Muscular hypotonia0.3097InformativeInherited
Phenotypic Abnormality (PA)Generalized neonatal hypotonia9.313e-06Highly InformativeDirect
Phenotypic Abnormality (PA)Brushfield spots0.0001103Highly InformativeDirect
Phenotypic Abnormality (PA)Thickened nuchal skin fold0.0003584Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.69Least InformativeInherited
Mammalian Phenotype (MP)tumorigenesis0.002188Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.03085Moderately InformativeInherited
Mammalian Phenotype (MP)muscle phenotype0.2034Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeletal muscle morphology0.02296InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin secretion0.4979InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin-2 secretion0.02193Highly InformativeInherited
Mammalian Phenotype (MP)abnormal skeletal muscle fiber morphology0.0417Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant1.122e-15Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.5632Least InformativeInherited
Worm Phenotype (WP)protein aggregation variant0Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant2.914e-09Moderately InformativeDirect
Worm Phenotype (WP)cell homeostasis metabolism variant0.00099Moderately InformativeDirect
Worm Phenotype (WP)cell stress response variant7.14e-09InformativeDirect
Worm Phenotype (WP)neuron development variant0.2742InformativeInherited
Worm Phenotype (WP)cell ionizing radiation response variant4.226e-08Highly InformativeDirect
Worm Phenotype (WP)axon morphology variant0.1107Highly InformativeInherited
Worm Phenotype (WP)germ cell ionizing radiation response variant0.1541Highly InformativeInherited

Document: WP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)gonad0.00195Least InformativeInherited
Xenopus ANatomical entity (XAN)ovary0.0005953Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)plant cell0.01524Least InformativeInherited
Plant ANatomical entity (PAN)pollen tube cell2.216e-06InformativeDirect
Plant ANatomical entity (PAN)leaf epidermis0.0001639Highly InformativeDirect
Plant ANatomical entity (PAN)trichome0.003187Highly InformativeInherited
Plant structure DEvelopment stage (PDE)pollen development stage1.352e-05Moderately InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases3.291e-15Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases1.472e-08Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases0.0001021Moderately InformativeDirect
Enzyme Commission (EC)Isomerases0.03707Moderately InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0.0895Moderately InformativeInherited
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds1Moderately InformativeInherited
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)Hexosyltransferases0InformativeDirect
Enzyme Commission (EC)Omega peptidases0InformativeDirect
Enzyme Commission (EC)In linear amides0.1313InformativeInherited
Enzyme Commission (EC)Acid--D-amino-acid ligases (peptide synthases)0.211InformativeInherited
Enzyme Commission (EC)Histone acetyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Peptidylprolyl isomerase1.039e-12Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

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KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0Moderately InformativeDirect
Biological processTranscription regulation1.771e-12Moderately InformativeDirect
Biological processHost-virus interaction1.962e-12Moderately InformativeDirect
Biological processCell cycle3.907e-10Moderately InformativeDirect
Biological processDNA damage5.49e-06Moderately InformativeDirect
Biological processDifferentiation0.0005869Moderately InformativeDirect
Biological processMitosis0InformativeDirect
Biological processUbl conjugation pathway0InformativeDirect
Biological processEndocytosis1.074e-14InformativeDirect
Biological processWnt signaling pathway4.222e-14InformativeDirect
Biological processmRNA splicing2.782e-09InformativeDirect
Biological processPlant defense2.037e-06InformativeDirect
Biological processMeiosis0.0001168InformativeDirect
Biological processViral immunoevasion0.04228InformativeInherited
Biological processAntiviral defense0Highly InformativeDirect
Biological processNotch signaling pathway0Highly InformativeDirect
Biological processAutophagy2.025e-11Highly InformativeDirect
Biological processVirus exit from host cell1.065e-09Highly InformativeDirect
Biological processSpliceosome7.737e-06Highly InformativeDirect
Biological processViral budding via the host ESCRT complexes3.276e-05Highly InformativeDirect
Biological processModulation of host cell apoptosis by virus0.0001327Highly InformativeDirect
Biological processExocytosis0.0008956Highly InformativeDirect
Biological processModulation of host cell cycle by virus0.01081Highly InformativeInherited
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentEndosome0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle8.412e-15Moderately InformativeDirect
Cellular componentCytoskeleton2.185e-10Moderately InformativeDirect
Cellular componentGolgi apparatus6.923e-09Moderately InformativeDirect
Cellular componentCell junction1.92e-06Moderately InformativeDirect
Cellular componentMitochondrion1Moderately InformativeInherited
Cellular componentLysosome0InformativeDirect
Cellular componentPeroxisome0InformativeDirect
Cellular componentChromosome3.815e-11InformativeDirect
Cellular componentMitochondrion outer membrane1.005e-07InformativeDirect
Cellular componentSynapse6.726e-06InformativeDirect
Cellular componentHost cytoplasm1.522e-05InformativeDirect
Cellular componentPostsynaptic cell membrane6.504e-05InformativeDirect
Cellular componentLipid droplet3.578e-07Highly InformativeDirect
Cellular componentHost endosome0.0003889Highly InformativeDirect
Coding sequence diversityAlternative splicing5.506e-13Least InformativeDirect
Developmental stageEarly protein0.0001552Least InformativeDirect
DiseaseTumor suppressor0.0004781Moderately InformativeDirect
DiseaseOsteopetrosis3.185e-08Highly InformativeDirect
DomainRepeat1.809e-13Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainANK repeat0.0005989InformativeDirect
DomainBromodomain4.76e-09Highly InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionZinc-finger0Moderately InformativeDirect
Molecular functionActin-binding0.0004169InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationLigase0Moderately InformativeDirect
Post-translational modificationRepressor0Moderately InformativeDirect
Post-translational modificationDevelopmental protein6.803e-10Moderately InformativeDirect
Post-translational modificationActivator6.68e-06Moderately InformativeDirect
Post-translational modificationProtease0.009722Moderately InformativeInherited
Post-translational modificationChromatin regulator0InformativeDirect
Post-translational modificationThiol protease0InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond5.728e-13Moderately InformativeDirect
Post-translational modificationMyristate0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect
UniPathway (UP)glycan metabolism1Moderately InformativeInherited
UniPathway (UP)cellulose metabolism4.459e-16InformativeDirect
UniPathway (UP)cellulose biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 27 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a RING/U-box domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 27 hidden Markov models representing the RING/U-box superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]