SUPERFAMILY 1.75 HMM library and genome assignments server


B-box zinc-binding domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   B-box zinc-binding domain [ 57844]
Superfamily:   B-box zinc-binding domain [ 57845]
Families:   B-box zinc-binding domain [ 57846] (7)


Superfamily statistics
Genomes (346) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 8,577 8,795 7
Proteins 8,477 8,721 7


Functional annotation
General category General
Detailed category Ion binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 2.51e-12 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 1.594e-05 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.0001594 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.3525 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.6452 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) immune system process 8.479e-10 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 1.399e-07 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 1.999e-07 Moderately Informative Direct
Biological Process (BP) regulation of signaling 7.951e-07 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 2.047e-06 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 6.918e-06 Moderately Informative Direct
Biological Process (BP) regulation of biosynthetic process 0.0005639 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.2852 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.536 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 0.2105 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.5091 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.5591 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 0.001177 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.001011 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.8096 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.01717 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.2938 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.2938 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.5516 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.003337 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.1593 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.01215 Moderately Informative Inherited
Biological Process (BP) protein modification by small protein conjugation or removal 0 Informative Direct
Biological Process (BP) positive regulation of immune system process 5.102e-13 Informative Direct
Biological Process (BP) regulation of immune response 2.26e-09 Informative Direct
Biological Process (BP) regulation of response to stress 1.079e-07 Informative Direct
Biological Process (BP) protein oligomerization 4.35e-07 Informative Direct
Biological Process (BP) positive regulation of signal transduction 4.88e-07 Informative Direct
Biological Process (BP) regulation of intracellular protein kinase cascade 5.491e-07 Informative Direct
Biological Process (BP) regulation of cell proliferation 0.2149 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.008063 Informative Inherited
Biological Process (BP) cell proliferation 0.07035 Informative Inherited
Biological Process (BP) defense response 0.1426 Informative Inherited
Biological Process (BP) immune effector process 0.7681 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0.03703 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 0.5996 Informative Inherited
Biological Process (BP) cell cycle process 0.7014 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.2462 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.007874 Informative Inherited
Biological Process (BP) negative regulation of cellular metabolic process 0.127 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.3107 Informative Inherited
Biological Process (BP) response to lipid 0.04898 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.9307 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 0.08081 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.1889 Informative Inherited
Biological Process (BP) chordate embryonic development 0.1053 Informative Inherited
Biological Process (BP) response to other organism 0.3778 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.08278 Informative Inherited
Biological Process (BP) cellular membrane organization 0.2525 Informative Inherited
Biological Process (BP) protein catabolic process 0.02106 Informative Inherited
Biological Process (BP) proteolysis 0.7156 Informative Inherited
Biological Process (BP) response to wounding 0.13 Informative Inherited
Biological Process (BP) regulation of multi-organism process 0 Highly Informative Direct
Biological Process (BP) activation of immune response 0 Highly Informative Direct
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 0 Highly Informative Direct
Biological Process (BP) protein ubiquitination 0 Highly Informative Direct
Biological Process (BP) immune response-regulating signaling pathway 0 Highly Informative Direct
Biological Process (BP) regulation of innate immune response 5.177e-11 Highly Informative Direct
Biological Process (BP) positive regulation of MAPK cascade 3.949e-08 Highly Informative Direct
Biological Process (BP) regulation of neural precursor cell proliferation 6.426e-07 Highly Informative Direct
Biological Process (BP) regulation of microtubule polymerization or depolymerization 7.078e-07 Highly Informative Direct
Biological Process (BP) stem cell proliferation 7.441e-07 Highly Informative Direct
Biological Process (BP) response to virus 6.583e-06 Highly Informative Direct
Biological Process (BP) regulation of protein complex disassembly 6.743e-06 Highly Informative Direct
Biological Process (BP) modification-dependent protein catabolic process 7.721e-06 Highly Informative Direct
Biological Process (BP) negative regulation of cytoskeleton organization 4.548e-05 Highly Informative Direct
Biological Process (BP) plasma membrane organization 5.095e-05 Highly Informative Direct
Biological Process (BP) regulation of protein catabolic process 9.321e-05 Highly Informative Direct
Biological Process (BP) cell cycle phase transition 0.0003745 Highly Informative Direct
Biological Process (BP) regulation of protein stability 0.0005963 Highly Informative Direct
Biological Process (BP) cell cycle phase 0.001127 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 0.00167 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular macromolecule biosynthetic process 0.4874 Highly Informative Inherited
Biological Process (BP) negative regulation of gene expression 0.358 Highly Informative Inherited
Biological Process (BP) regulation of gene expression, epigenetic 0.2655 Highly Informative Inherited
Biological Process (BP) regulation of translation 0.04929 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.2537 Highly Informative Inherited
Biological Process (BP) wound healing 0.1115 Highly Informative Inherited
Biological Process (BP) mitotic cell cycle 0.05983 Highly Informative Inherited
Molecular Function (MF) binding 0.007586 Least Informative Inherited
Molecular Function (MF) protein binding 0.0009135 Moderately Informative Direct
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) heterocyclic compound binding 1 Moderately Informative Inherited
Molecular Function (MF) organic cyclic compound binding 1 Moderately Informative Inherited
Molecular Function (MF) cation binding 0.1721 Moderately Informative Inherited
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 0 Informative Direct
Molecular Function (MF) molecular transducer activity 9.088e-11 Informative Direct
Molecular Function (MF) receptor activity 1.155e-08 Informative Direct
Molecular Function (MF) carboxylic acid binding 0.001246 Informative Inherited
Molecular Function (MF) RNA binding 0.2744 Informative Inherited
Molecular Function (MF) transition metal ion binding 0.05461 Informative Inherited
Molecular Function (MF) lipid binding 0.1836 Informative Inherited
Molecular Function (MF) small conjugating protein ligase activity 0 Highly Informative Direct
Molecular Function (MF) modified amino acid binding 7.46e-07 Highly Informative Direct
Molecular Function (MF) zinc ion binding 4.3e-05 Highly Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) ribonucleoprotein complex 6.119e-13 Moderately Informative Direct
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.2929 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.3704 Moderately Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 0.04123 Informative Inherited
Cellular Component (CC) chromosome 1 Informative Inherited
Cellular Component (CC) cytoplasmic mRNA processing body 0 Highly Informative Direct
Cellular Component (CC) sarcolemma 0.0001299 Highly Informative Direct
Cellular Component (CC) microtubule associated complex 0.0003703 Highly Informative Direct
Cellular Component (CC) chromatin 0.8527 Highly Informative Inherited
Cellular Component (CC) nuclear chromosome part 0.3289 Highly Informative Inherited

Document: GO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)muscle phenotype0.1714Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeletal muscle morphology0.06461InformativeInherited
Mammalian Phenotype (MP)abnormal skeletal muscle fiber morphology0.02431Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.004183Least InformativeInherited
Worm Phenotype (WP)protein aggregation variant1.611e-06Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant6.937e-05Moderately InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)lethal0Least InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)cell0Least InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis1.767e-07Moderately InformativeDirect
Biological processInnate immunity0InformativeDirect
Biological processUbl conjugation pathway0InformativeDirect
Biological processAntiviral defense0Highly InformativeDirect
Biological processRNA-mediated gene silencing4.032e-10Highly InformativeDirect
Biological processExocytosis8.516e-10Highly InformativeDirect
Cellular componentCytoplasm5.061e-11Least InformativeDirect
Cellular componentNucleus8.358e-09Least InformativeDirect
Cellular componentCytoskeleton1.46e-09Moderately InformativeDirect
Cellular componentCytoplasmic vesicle1.464e-09Moderately InformativeDirect
Cellular componentMicrotubule1.061e-12InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainBromodomain8.624e-13Highly InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionZinc-finger0Moderately InformativeDirect
Post-translational modificationLigase0Moderately InformativeDirect
Post-translational modificationDevelopmental protein2.051e-07Moderately InformativeDirect
Post-translational modificationRepressor4.181e-05Moderately InformativeDirect
Post-translational modificationMuscle protein7.673e-06Highly InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 7 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a B-box zinc-binding domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 7 hidden Markov models representing the B-box zinc-binding domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]