SUPERFAMILY 1.75 HMM library and genome assignments server

Casein kinase II beta subunit superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Rubredoxin-like [ 57769] (17)
Superfamily:   Casein kinase II beta subunit [ 57798]
Families:   Casein kinase II beta subunit [ 57799]


Superfamily statistics
Genomes (487) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,376 1,447 4
Proteins 1,363 1,430 4


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of metabolic process0.28570.2516Least InformativeInherited
Biological Process (BP)regulation of cellular process0.0088830.463Least InformativeInherited
Biological Process (BP)protein metabolic process0.0015520.0002911Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.0066460.001861Least InformativeInherited
Biological Process (BP)cellular protein modification process0.000030650.000003742Moderately InformativeDirect
Biological Process (BP)phosphate-containing compound metabolic process0.00057570.00001446Moderately InformativeDirect
Biological Process (BP)regulation of catalytic activity0.00052320.000004588Moderately InformativeDirect
Biological Process (BP)regulation of phosphorus metabolic process0.00023480.000005262Moderately InformativeDirect
Biological Process (BP)regulation of protein metabolic process0.00064480.00001011Moderately InformativeDirect
Biological Process (BP)regulation of protein phosphorylation0.000010330.00000001737InformativeDirect
Biological Process (BP)phosphorylation0.00000059460.00000000592InformativeDirect
Biological Process (BP)regulation of transferase activity0.0000032730.00000000302InformativeDirect
Biological Process (BP)protein phosphorylation0.000000010850.0000000001309Highly InformativeDirect
Molecular Function (MF)binding0.000024830.003244Least InformativeInherited
Molecular Function (MF)transferase activity0.03410.0478Least InformativeInherited
Molecular Function (MF)enzyme regulator activity0.000050430.000000001718Moderately InformativeDirect
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups0.00034740.002045Moderately InformativeInherited
Molecular Function (MF)kinase activity0.00013750.0009028InformativeDirect
Molecular Function (MF)phosphotransferase activity, alcohol group as acceptor0.000037720.0005307InformativeDirect
Molecular Function (MF)protein kinase activity0.0000091770.0001255Highly InformativeDirect
Molecular Function (MF)protein kinase regulator activity0.0000000005680Highly InformativeDirect
Cellular Component (CC)protein complex0.00012960.00003448Least InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.00045560.02359Least InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0.0002911 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.2516 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.463 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.001861 Least Informative Inherited
Biological Process (BP) cellular protein modification process 0.000003742 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0.00001446 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0.000004588 Moderately Informative Direct
Biological Process (BP) regulation of phosphorus metabolic process 0.000005262 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.00001011 Moderately Informative Direct
Biological Process (BP) regulation of protein phosphorylation 0.00000001737 Informative Direct
Biological Process (BP) phosphorylation 0.00000000592 Informative Direct
Biological Process (BP) regulation of transferase activity 0.00000000302 Informative Direct
Biological Process (BP) protein phosphorylation 0.0000000001309 Highly Informative Direct
Molecular Function (MF) binding 0.003244 Least Informative Inherited
Molecular Function (MF) transferase activity 0.0478 Least Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.000000001718 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.002045 Moderately Informative Inherited
Molecular Function (MF) kinase activity 0.0009028 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.0005307 Informative Direct
Molecular Function (MF) protein kinase activity 0.0001255 Highly Informative Direct
Molecular Function (MF) protein kinase regulator activity 0 Highly Informative Direct
Cellular Component (CC) protein complex 0.00003448 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.02359 Least Informative Inherited

Document: GO annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0Least InformativeDirect
Plant ANatomical entity (PAN)portion of meristem tissue0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)cotyledon0Moderately InformativeDirect
Plant ANatomical entity (PAN)inflorescence meristem0Moderately InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processWnt signaling pathway0InformativeDirect
Coding sequence diversityAlternative splicing0.00006799Least InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000704 SSF57798 Protein matches
Abstract

Casein kinase, a ubiquitous, well-conserved protein kinase involved in cell metabolism and differentiation, is characterised by its preference for Ser or Thr in acidic stretches of amino acids. The enzyme is a tetramer of 2 alpha- and 2 beta-subunits [PubMed2666134, PubMed1856204]. However, some species (e.g., mammals) possess 2 related forms of the alpha-subunit (alpha and alpha'), while others (e.g., fungi) possess 2 related beta-subunits (beta and beta') [PubMed7737972]. The alpha-subunit is the catalytic unit and contains regions characteristic of serine/threonine protein kinases. The beta-subunit is believed to be regulatory, possessing an N-terminal auto-phosphorylation site, an internal acidic domain, and a potential metal-binding motif [PubMed7737972]. The beta subunit is a highly conserved protein of about 25 kD that contains, in its central section, a cysteine-rich motif that could be involved in binding a metal such as zinc [PubMed8027080]. The mammalian beta-subunit gene promoter shares common features with those of other mammalian protein kinases and is closely related to the promoter of the regulatory subunit of cAMP-dependent protein kinase [PubMed7737972].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Casein kinase II beta subunit domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Casein kinase II beta subunit superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]