SUPERFAMILY 1.75 HMM library and genome assignments server


Retrovirus zinc finger-like domains superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Retrovirus zinc finger-like domains [ 57755]
Superfamily:   Retrovirus zinc finger-like domains [ 57756]
Families:   Retrovirus zinc finger-like domains [ 57757] (5)


Superfamily statistics
Genomes (446) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 23,275 40,381 13
Proteins 19,755 37,336 12


Functional annotation
General category Other
Detailed category Viral proteins

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 7.835e-15 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 1.747e-11 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 1.711e-09 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 2.076e-15 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 1.84e-13 Least Informative Direct
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) developmental process 0.1291 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.7056 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.5436 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.008686 Least Informative Inherited
Biological Process (BP) negative regulation of metabolic process 4.186e-05 Moderately Informative Direct
Biological Process (BP) gene expression 1.584e-10 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 7.835e-15 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.02664 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.2169 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.1072 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.003098 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.001485 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.07141 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.4222 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.0114 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.003154 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.008698 Moderately Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 4.948e-09 Informative Direct
Biological Process (BP) response to organic cyclic compound 3.041e-08 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 2.456e-07 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 3.031e-12 Informative Direct
Biological Process (BP) ncRNA processing 0.5969 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.001808 Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 0.002832 Informative Inherited
Biological Process (BP) response to cold 1.388e-06 Highly Informative Direct
Biological Process (BP) negative regulation of gene expression 0.0003142 Highly Informative Direct
Biological Process (BP) RNA 3'-end processing 7.805e-08 Highly Informative Direct
Biological Process (BP) regulation of gene expression, epigenetic 1.716e-14 Highly Informative Direct
Biological Process (BP) stem cell development 4.095e-05 Highly Informative Direct
Biological Process (BP) cellular response to organic cyclic compound 6.78e-13 Highly Informative Direct
Biological Process (BP) RNA splicing, via transesterification reactions 0.1083 Highly Informative Inherited
Molecular Function (MF) transferase activity 0.9942 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) binding 0.3078 Least Informative Inherited
Molecular Function (MF) organic cyclic compound binding 3.177e-05 Moderately Informative Direct
Molecular Function (MF) heterocyclic compound binding 2.236e-05 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.2549 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.4904 Moderately Informative Inherited
Molecular Function (MF) RNA binding 1.261e-08 Informative Direct
Molecular Function (MF) nucleotidyltransferase activity 2.394e-07 Informative Direct
Molecular Function (MF) nuclease activity 0.001426 Informative Inherited
Cellular Component (CC) intracellular organelle part 0.0009734 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.006828 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.2232 Least Informative Inherited
Cellular Component (CC) ribonucleoprotein complex 1.425e-10 Moderately Informative Direct
Cellular Component (CC) nuclear part 4.116e-07 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0.004873 Moderately Informative Inherited
Cellular Component (CC) nucleoplasm part 0.6456 Informative Inherited
Cellular Component (CC) cytoplasmic mRNA processing body 3.555e-10 Highly Informative Direct
Cellular Component (CC) spliceosomal complex 0.0003223 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides1Least InformativeInherited
Enzyme Commission (EC)Endoribonucleases producing 5'-phosphomonoesters0Moderately InformativeDirect
Enzyme Commission (EC)DNA-directed DNA polymerase0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an2.155e-05Moderately InformativeDirect
Enzyme Commission (EC)Retroviral ribonuclease H0InformativeDirect
Enzyme Commission (EC)Exoribonuclease H0InformativeDirect
Enzyme Commission (EC)Aspartic endopeptidases0InformativeDirect
Enzyme Commission (EC)RNA-directed DNA polymerase0InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)preweaning lethality0Moderately InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)cell0Least InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)cell0Least InformativeDirect
Xenopus ANatomical entity (XAN)gamete0Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides1Moderately InformativeInherited
Enzyme Commission (EC)DNA-directed DNA polymerase0InformativeDirect
Enzyme Commission (EC)Exoribonucleases producing 5'-phosphomonoesters0InformativeDirect
Enzyme Commission (EC)Endoribonucleases producing 5'-phosphomonoesters0InformativeDirect
Enzyme Commission (EC)RNA helicase0.000204InformativeDirect
Enzyme Commission (EC)RNA-directed DNA polymerase0Highly InformativeDirect
Enzyme Commission (EC)Exoribonuclease H0Highly InformativeDirect
Enzyme Commission (EC)Retroviral ribonuclease H0Highly InformativeDirect
Enzyme Commission (EC)HIV-1 retropepsin0Highly InformativeDirect
Enzyme Commission (EC)RNA uridylyltransferase1.135e-07Highly InformativeDirect
Enzyme Commission (EC)HIV-2 retropepsin4.202e-05Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processHost-virus interaction0Moderately InformativeDirect
Biological processDNA recombination0InformativeDirect
Biological processVirus entry into host cell0InformativeDirect
Biological processCapsid maturation0Highly InformativeDirect
Biological processModulation of host cell apoptosis by virus0Highly InformativeDirect
Biological processViral penetration into host nucleus0Highly InformativeDirect
Biological processViral genome integration0Highly InformativeDirect
Biological processViral budding via the host ESCRT complexes0Highly InformativeDirect
Biological processVirus exit from host cell0Highly InformativeDirect
Biological processRNA-mediated gene silencing1.826e-15Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus5.378e-07Least InformativeDirect
Cellular componentVirion0InformativeDirect
Cellular componentHost cytoplasm0InformativeDirect
Cellular componentHost membrane0InformativeDirect
Cellular componentHost nucleus0InformativeDirect
Cellular componentViral nucleoprotein0Highly InformativeDirect
Cellular componentHost endosome0Highly InformativeDirect
Cellular componentViral matrix protein6.25e-15Highly InformativeDirect
Coding sequence diversityRibosomal frameshifting0Moderately InformativeDirect
Coding sequence diversityRNA suppression of termination0.0007381InformativeDirect
DiseaseAIDS0Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionDNA-binding0Moderately InformativeDirect
Molecular functionRNA-binding0Moderately InformativeDirect
Molecular functionZinc-finger0Moderately InformativeDirect
Molecular functionMagnesium1.971e-10Moderately InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase0.01385Least InformativeInherited
Post-translational modificationNuclease0Moderately InformativeDirect
Post-translational modificationNucleotidyltransferase0Moderately InformativeDirect
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationCapsid protein0InformativeDirect
Post-translational modificationDNA-directed DNA polymerase0InformativeDirect
Post-translational modificationEndonuclease2.877e-11InformativeDirect
Post-translational modificationAspartyl protease0Highly InformativeDirect
Post-translational modificationRNA-directed DNA polymerase0Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationMethylation3.026e-09Moderately InformativeDirect
Post-translational modificationMyristate0InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Retrovirus zinc finger-like domains domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the Retrovirus zinc finger-like domains superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]