SUPERFAMILY 1.75 HMM library and genome assignments server


beta-beta-alpha zinc fingers superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   beta-beta-alpha zinc fingers [ 57666]
Superfamily:   beta-beta-alpha zinc fingers [ 57667] (7)
Families:   Classic zinc finger, C2H2 [ 57668] (30)
  Plant C2H2 finger (QALGGH zinc finger) [ 90198]
  C2HC finger [ 57697] (3)
  HkH motif-containing C2H2 finger [ 111436] (4)
  CHHC finger [ 161158]
  variant C2H2 finger [ 118273]
  BED zinc finger [ 144157]


Superfamily statistics
Genomes (498) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 250,432 246,363 212
Proteins 73,446 75,020 173


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of metabolic process0.13450Least InformativeInherited
Biological Process (BP)regulation of cellular process0.11650Least InformativeInherited
Biological Process (BP)regulation of gene expression1.591e-060Moderately InformativeDirect
Biological Process (BP)positive regulation of metabolic process0.00012217.162e-06Moderately InformativeDirect
Biological Process (BP)regulation of response to stimulus0.68251Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.018390.1559Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.062681Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.11867.087e-09Moderately InformativeInherited
Biological Process (BP)regulation of biosynthetic process0.0014410Moderately InformativeInherited
Biological Process (BP)regulation of nitrogen compound metabolic process0.0021550Moderately InformativeInherited
Biological Process (BP)regulation of cellular metabolic process0.10310Moderately InformativeInherited
Biological Process (BP)regulation of immune effector process6.051e-061InformativeInherited
Biological Process (BP)regulation of cell development0.52320.5203InformativeInherited
Biological Process (BP)negative regulation of developmental process0.0023412.663e-06InformativeInherited
Biological Process (BP)regulation of immune response0.0015341InformativeInherited
Biological Process (BP)negative regulation of response to stimulus0.005371InformativeInherited
Biological Process (BP)regulation of leukocyte differentiation1.029e-060Highly InformativeDirect
Biological Process (BP)regulation of lymphocyte activation7.905e-061.512e-06Highly InformativeDirect
Biological Process (BP)negative regulation of immune system process0.00010741Highly InformativeInherited
Molecular Function (MF)binding0.2020.0004137Least InformativeInherited
Molecular Function (MF)heterocyclic compound binding3.782e-050Moderately InformativeDirect
Molecular Function (MF)organic cyclic compound binding5.904e-050Moderately InformativeDirect
Molecular Function (MF)DNA binding4.234e-110InformativeDirect
Molecular Function (MF)chromatin binding1.584e-050Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0 Least Informative Direct
Biological Process (BP) developmental process 1.012e-09 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.004385 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) regulation of gene expression 0 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 7.162e-06 Moderately Informative Direct
Biological Process (BP) regulation of biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of nitrogen compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) organ development 4.657e-10 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 0 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.000216 Moderately Informative Direct
Biological Process (BP) cell differentiation 3.725e-07 Moderately Informative Direct
Biological Process (BP) regulation of cellular metabolic process 0 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 7.087e-09 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 1.749e-06 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0 Moderately Informative Direct
Biological Process (BP) tissue development 0.0003091 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.7158 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.9068 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.1559 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.4479 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.3898 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.1105 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.9701 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.9904 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.9052 Moderately Informative Inherited
Biological Process (BP) gene expression 0.3683 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.9969 Moderately Informative Inherited
Biological Process (BP) negative regulation of developmental process 2.663e-06 Informative Direct
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0 Informative Direct
Biological Process (BP) negative regulation of biosynthetic process 3.868e-13 Informative Direct
Biological Process (BP) negative regulation of cellular metabolic process 0 Informative Direct
Biological Process (BP) embryonic morphogenesis 4.008e-15 Informative Direct
Biological Process (BP) transcription, DNA-dependent 3.476e-09 Informative Direct
Biological Process (BP) sensory organ development 2.138e-08 Informative Direct
Biological Process (BP) hematopoietic or lymphoid organ development 4.312e-07 Informative Direct
Biological Process (BP) organ morphogenesis 2.722e-06 Informative Direct
Biological Process (BP) multicellular organismal reproductive process 2.25e-05 Informative Direct
Biological Process (BP) embryonic organ development 3.82e-05 Informative Direct
Biological Process (BP) sexual reproduction 5.134e-05 Informative Direct
Biological Process (BP) cell activation 0.0003502 Informative Direct
Biological Process (BP) tube development 0.0004987 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 1 Informative Inherited
Biological Process (BP) regulation of cell proliferation 1 Informative Inherited
Biological Process (BP) regulation of growth 1 Informative Inherited
Biological Process (BP) regulation of response to stress 1 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.004269 Informative Inherited
Biological Process (BP) response to lipid 0.8855 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) response to hormone stimulus 1 Informative Inherited
Biological Process (BP) cell proliferation 0.004979 Informative Inherited
Biological Process (BP) cardiovascular system development 0.213 Informative Inherited
Biological Process (BP) chordate embryonic development 0.4849 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.8739 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.001857 Informative Inherited
Biological Process (BP) growth 1 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.9932 Informative Inherited
Biological Process (BP) positive regulation of immune system process 1 Informative Inherited
Biological Process (BP) cell projection organization 1 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 1 Informative Inherited
Biological Process (BP) regulation of secretion 1 Informative Inherited
Biological Process (BP) regulation of cell development 0.5203 Informative Inherited
Biological Process (BP) regulation of immune effector process 1 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) negative regulation of molecular function 1 Informative Inherited
Biological Process (BP) muscle tissue development 0.9053 Informative Inherited
Biological Process (BP) muscle structure development 0.3132 Informative Inherited
Biological Process (BP) gland development 0.04756 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.7979 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.9148 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.03134 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.3521 Informative Inherited
Biological Process (BP) locomotion 1 Informative Inherited
Biological Process (BP) single-organism behavior 0.9173 Informative Inherited
Biological Process (BP) central nervous system development 0.01418 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) chromosome organization 0.1084 Informative Inherited
Biological Process (BP) DNA metabolic process 1 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.002006 Informative Inherited
Biological Process (BP) regulation of cell cycle process 1 Informative Inherited
Biological Process (BP) regulation of reproductive process 0.8031 Informative Inherited
Biological Process (BP) protein modification by small protein conjugation or removal 1 Informative Inherited
Biological Process (BP) single organism reproductive process 0.001046 Informative Inherited
Biological Process (BP) immune response 1 Informative Inherited
Biological Process (BP) localization of cell 0.8518 Informative Inherited
Biological Process (BP) cellular component movement 1 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.3835 Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0 Highly Informative Direct
Biological Process (BP) regulation of lymphocyte activation 1.512e-06 Highly Informative Direct
Biological Process (BP) negative regulation of RNA metabolic process 0 Highly Informative Direct
Biological Process (BP) negative regulation of gene expression 0 Highly Informative Direct
Biological Process (BP) negative regulation of cellular macromolecule biosynthetic process 5.668e-08 Highly Informative Direct
Biological Process (BP) lymphocyte differentiation 1.213e-11 Highly Informative Direct
Biological Process (BP) pattern specification process 1.881e-10 Highly Informative Direct
Biological Process (BP) kidney development 1.838e-09 Highly Informative Direct
Biological Process (BP) stem cell development 2.009e-08 Highly Informative Direct
Biological Process (BP) gonad development 1.377e-06 Highly Informative Direct
Biological Process (BP) neural precursor cell proliferation 1.491e-05 Highly Informative Direct
Biological Process (BP) erythrocyte differentiation 1.503e-05 Highly Informative Direct
Biological Process (BP) regulation of myeloid cell differentiation 0.0001127 Highly Informative Direct
Biological Process (BP) regulation of steroid biosynthetic process 0.0001527 Highly Informative Direct
Biological Process (BP) cell fate commitment 0.0002453 Highly Informative Direct
Biological Process (BP) post-embryonic organ development 0.0003804 Highly Informative Direct
Biological Process (BP) leukocyte homeostasis 0.0004058 Highly Informative Direct
Biological Process (BP) T cell activation 0.0006068 Highly Informative Direct
Biological Process (BP) post-embryonic development 0.0007372 Highly Informative Direct
Biological Process (BP) negative regulation of reproductive process 0.02715 Highly Informative Inherited
Biological Process (BP) regulation of neural precursor cell proliferation 0.02668 Highly Informative Inherited
Biological Process (BP) negative regulation of lipid biosynthetic process 0.4467 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 1 Highly Informative Inherited
Biological Process (BP) regulation of response to nutrient levels 1 Highly Informative Inherited
Biological Process (BP) regulation of cell adhesion 1 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 0.7899 Highly Informative Inherited
Biological Process (BP) cellular response to abiotic stimulus 0.02292 Highly Informative Inherited
Biological Process (BP) cellular response to organic cyclic compound 0.197 Highly Informative Inherited
Biological Process (BP) response to corticosteroid stimulus 0.3697 Highly Informative Inherited
Biological Process (BP) response to acid 0.02557 Highly Informative Inherited
Biological Process (BP) response to cold 0.8383 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.00972 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 1 Highly Informative Inherited
Biological Process (BP) cardiocyte differentiation 0.8812 Highly Informative Inherited
Biological Process (BP) cardiac muscle tissue development 1 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.9846 Highly Informative Inherited
Biological Process (BP) developmental growth 1 Highly Informative Inherited
Biological Process (BP) modification of morphology or physiology of other organism 0.07653 Highly Informative Inherited
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.745 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.4222 Highly Informative Inherited
Biological Process (BP) organelle localization 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cell differentiation 0.467 Highly Informative Inherited
Biological Process (BP) positive regulation of cell activation 1 Highly Informative Inherited
Biological Process (BP) inner ear development 0.7486 Highly Informative Inherited
Biological Process (BP) skeletal system development 0.7063 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.8861 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.1015 Highly Informative Inherited
Biological Process (BP) regulation of adaptive immune response based on somatic recombination of immune receptors built from 0.6221 Highly Informative Inherited
Biological Process (BP) regulation of lymphocyte mediated immunity 0.8596 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 1 Highly Informative Inherited
Biological Process (BP) negative regulation of secretion 0.5062 Highly Informative Inherited
Biological Process (BP) regulation of insulin secretion 0.3016 Highly Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 1 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 1 Highly Informative Inherited
Biological Process (BP) photoreceptor cell differentiation 0.03011 Highly Informative Inherited
Biological Process (BP) multi-organism cellular process 0.08426 Highly Informative Inherited
Biological Process (BP) regulation of binding 0.5215 Highly Informative Inherited
Biological Process (BP) regulation of multicellular organism growth 0.007423 Highly Informative Inherited
Biological Process (BP) limb morphogenesis 0.007859 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.5143 Highly Informative Inherited
Biological Process (BP) endocrine system development 0.1598 Highly Informative Inherited
Biological Process (BP) negative regulation of signal transduction 0.009224 Highly Informative Inherited
Biological Process (BP) regulation of Ras protein signal transduction 1 Highly Informative Inherited
Biological Process (BP) DNA recombination 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 1 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 1 Highly Informative Inherited
Biological Process (BP) regulation of cellular ketone metabolic process 1 Highly Informative Inherited
Biological Process (BP) locomotory behavior 1 Highly Informative Inherited
Biological Process (BP) regulation of mononuclear cell proliferation 0.5568 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell differentiation 0.1976 Highly Informative Inherited
Biological Process (BP) B cell activation 0.002832 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.03456 Highly Informative Inherited
Biological Process (BP) histone modification 0.4287 Highly Informative Inherited
Biological Process (BP) protein deacylation 0.008346 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 1 Highly Informative Inherited
Biological Process (BP) protein ubiquitination 1 Highly Informative Inherited
Biological Process (BP) regulation of gene expression, epigenetic 1 Highly Informative Inherited
Biological Process (BP) regulation of organ morphogenesis 0.4383 Highly Informative Inherited
Biological Process (BP) epithelial tube morphogenesis 0.1903 Highly Informative Inherited
Biological Process (BP) morphogenesis of a branching epithelium 1 Highly Informative Inherited
Molecular Function (MF) binding 0.0004137 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) heterocyclic compound binding 0 Moderately Informative Direct
Molecular Function (MF) organic cyclic compound binding 0 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) protein binding 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) cation binding 0.2202 Moderately Informative Inherited
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) nucleic acid binding transcription factor activity 0 Informative Direct
Molecular Function (MF) transition metal ion binding 3.982e-07 Informative Direct
Molecular Function (MF) nucleotidyltransferase activity 1 Informative Inherited
Molecular Function (MF) enzyme binding 1 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) inorganic cation transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) RNA binding 1 Informative Inherited
Molecular Function (MF) chromatin binding 0 Highly Informative Direct
Molecular Function (MF) zinc ion binding 0 Highly Informative Direct
Molecular Function (MF) transcription factor binding 3.68e-07 Highly Informative Direct
Molecular Function (MF) structure-specific DNA binding 1 Highly Informative Inherited
Molecular Function (MF) ion gated channel activity 1 Highly Informative Inherited
Molecular Function (MF) ion channel activity 1 Highly Informative Inherited
Molecular Function (MF) transcription factor binding transcription factor activity 0.3729 Highly Informative Inherited
Molecular Function (MF) sequence-specific DNA binding transcription factor activity 1 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.08639 Moderately Informative Inherited
Cellular Component (CC) chromosome 2.06e-05 Informative Direct
Cellular Component (CC) nucleoplasm part 0.5586 Informative Inherited
Cellular Component (CC) nuclear body 2.647e-05 Highly Informative Direct
Cellular Component (CC) chromatin 0.006439 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring one-carbon groups0.0001316Least InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0.0006257Least InformativeDirect
Enzyme Commission (EC)Methyltransferases3.713e-10Moderately InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase1.404e-15InformativeDirect
Enzyme Commission (EC)RNA uridylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Polynucleotide adenylyltransferase2.368e-16Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0.0005911Least InformativeDirect
Mammalian Phenotype (MP)nervous system phenotype0.8182Least InformativeInherited
Mammalian Phenotype (MP)embryogenesis phenotype0.0002424Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal skeleton morphology0.014Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.1087Moderately InformativeInherited
Mammalian Phenotype (MP)preweaning lethality0.2906Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.6054Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cranium morphology0.006508InformativeInherited
Mammalian Phenotype (MP)prenatal lethality0.1695InformativeInherited
Mammalian Phenotype (MP)abnormal cranial nerve morphology0.09793Highly InformativeInherited
Mammalian Phenotype (MP)abnormal adrenal gland morphology0.3275Highly InformativeInherited
Mammalian Phenotype (MP)abnormal jaw morphology0.504Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.001305Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant1Least InformativeInherited
Worm Phenotype (WP)organism segment morphology variant6.849e-06Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant1.901e-05Moderately InformativeDirect
Worm Phenotype (WP)chemical response variant0.8802Moderately InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant1Moderately InformativeInherited
Worm Phenotype (WP)somatic gonad development variant1.549e-05InformativeDirect
Worm Phenotype (WP)male morphology variant0.0001141InformativeDirect
Worm Phenotype (WP)protruding vulva0.0004198InformativeDirect
Worm Phenotype (WP)sensillum morphology variant0.1617InformativeInherited
Worm Phenotype (WP)drug resistant0.2286InformativeInherited
Worm Phenotype (WP)egg laying variant0.3289InformativeInherited
Worm Phenotype (WP)cell migration variant0.3294InformativeInherited
Worm Phenotype (WP)protein expression variant0.4563InformativeInherited
Worm Phenotype (WP)lineage variant0.0001944Highly InformativeDirect
Worm Phenotype (WP)male tail development variant0.0005854Highly InformativeDirect
Worm Phenotype (WP)neuron migration variant0.01225Highly InformativeInherited
Worm Phenotype (WP)alimentary system morphology variant0.05746Highly InformativeInherited
Worm Phenotype (WP)antibody staining variant0.06336Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0.08072Least InformativeInherited
Fly Anatomy (FA)cell0.7714Least InformativeInherited
Fly Anatomy (FA)anatomical group0.0005281Moderately InformativeDirect
Fly Anatomy (FA)neuron0.3389Moderately InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.7103Least InformativeInherited
Xenopus ANatomical entity (XAN)portion of tissue1Least InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.3541Moderately InformativeInherited
Xenopus ANatomical entity (XAN)neural plate0.02417InformativeInherited
Xenopus ANatomical entity (XAN)neural plate border0.0002Highly InformativeDirect
Xenopus ANatomical entity (XAN)chordal neural plate0.01501Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)shoot apex1Least InformativeInherited
Plant ANatomical entity (PAN)root1Least InformativeInherited
Plant ANatomical entity (PAN)root tip0.0003439InformativeDirect
Plant ANatomical entity (PAN)reproductive shoot apex0.0002276Highly InformativeDirect
Plant ANatomical entity (PAN)primary root0.0004325Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0.9404Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups0.000134Moderately InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0.0006244Moderately InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase9.49e-16InformativeDirect
Enzyme Commission (EC)RNA uridylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Polynucleotide adenylyltransferase2.399e-16Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0Moderately InformativeDirect
Biological processTranscription regulation0Moderately InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processWnt signaling pathway0.0002277InformativeDirect
Biological processmRNA splicing0.008093InformativeInherited
Biological processSpliceosome6.66e-09Highly InformativeDirect
Biological processGrowth regulation0.0004438Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Coding sequence diversityPolymorphism0Moderately InformativeDirect
DiseaseTumor suppressor0.0004758Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionDNA-binding0Moderately InformativeDirect
Molecular functionZinc-finger0Moderately InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationRepressor0Moderately InformativeDirect
Post-translational modificationChromatin regulator2.323e-13InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein sumoylation3.343e-09Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 91 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a beta-beta-alpha zinc fingers domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 91 hidden Markov models representing the beta-beta-alpha zinc fingers superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]