SUPERFAMILY 1.75 HMM library and genome assignments server


beta-beta-alpha zinc fingers superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   beta-beta-alpha zinc fingers [ 57666]
Superfamily:   beta-beta-alpha zinc fingers [ 57667] (7)
Families:   Classic zinc finger, C2H2 [ 57668] (30)
  Plant C2H2 finger (QALGGH zinc finger) [ 90198]
  C2HC finger [ 57697] (3)
  HkH motif-containing C2H2 finger [ 111436] (4)
  CHHC finger [ 161158]
  variant C2H2 finger [ 118273]
  BED zinc finger [ 144157]


Superfamily statistics
Genomes (564) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 277,547 297,723 212
Proteins 81,570 97,219 173


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)developmental process0.0094020Least InformativeInherited
Biological Process (BP)multicellular organismal process0.029111.052e-13Least InformativeInherited
Biological Process (BP)regulation of cellular process0.11363.755e-15Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.16320Least InformativeInherited
Biological Process (BP)response to stimulus0.98891Least InformativeInherited
Biological Process (BP)regulation of gene expression1.239e-060Moderately InformativeDirect
Biological Process (BP)regulation of cellular biosynthetic process4.955e-060Moderately InformativeDirect
Biological Process (BP)regulation of nucleobase-containing compound metabolic process7.816e-060Moderately InformativeDirect
Biological Process (BP)positive regulation of metabolic process0.00013133.332e-09Moderately InformativeDirect
Biological Process (BP)regulation of macromolecule biosynthetic process0.0042370Moderately InformativeInherited
Biological Process (BP)organ development0.0056384.18e-11Moderately InformativeInherited
Biological Process (BP)tissue development0.06720.001623Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.14963.421e-11Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.022170.001695Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.078751Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.10780Moderately InformativeInherited
Biological Process (BP)immune system process0.011370.6991Moderately InformativeInherited
Biological Process (BP)positive regulation of nucleobase-containing compound metabolic process4.819e-059.494e-06InformativeDirect
Biological Process (BP)positive regulation of gene expression0.00034261.436e-05InformativeDirect
Biological Process (BP)regulation of immune effector process7.056e-061InformativeInherited
Biological Process (BP)negative regulation of developmental process0.0046220.0005472InformativeInherited
Biological Process (BP)regulation of immune response0.0012911InformativeInherited
Biological Process (BP)negative regulation of immune system process0.00010761InformativeInherited
Biological Process (BP)regulation of cell activation0.00046780.08151InformativeInherited
Biological Process (BP)sensory organ development0.02211.529e-07InformativeInherited
Biological Process (BP)negative regulation of response to stimulus0.0084551InformativeInherited
Biological Process (BP)response to wounding0.00069431InformativeInherited
Biological Process (BP)immune response0.0023921InformativeInherited
Biological Process (BP)defense response0.014731InformativeInherited
Biological Process (BP)mesenchyme development4.235e-061.75e-05Highly InformativeDirect
Biological Process (BP)regulation of leukocyte differentiation4.389e-050Highly InformativeDirect
Biological Process (BP)negative regulation of immune effector process6.03e-090.02833Highly InformativeInherited
Biological Process (BP)negative regulation of leukocyte activation8.3e-080.08678Highly InformativeInherited
Biological Process (BP)negative regulation of cell differentiation0.0046040.003883Highly InformativeInherited
Biological Process (BP)regulation of T cell activation1.036e-060.1297Highly InformativeInherited
Biological Process (BP)negative regulation of immune response7.174e-080.072Highly InformativeInherited
Biological Process (BP)inflammatory response1.413e-050.363Highly InformativeInherited
Molecular Function (MF)binding0.17621.036e-11Least InformativeInherited
Molecular Function (MF)nucleic acid binding1.866e-080Moderately InformativeDirect
Molecular Function (MF)DNA binding2.363e-110InformativeDirect
Molecular Function (MF)chromatin binding1.447e-050InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 1.052e-13 Least Informative Direct
Biological Process (BP) regulation of cellular process 3.755e-15 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) regulation of gene expression 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 3.332e-09 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 2.728e-05 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) organ development 4.18e-11 Moderately Informative Direct
Biological Process (BP) cell differentiation 2.976e-07 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 3.421e-11 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0.0003782 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.001623 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.2132 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.557 Moderately Informative Inherited
Biological Process (BP) immune system process 0.6991 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.7723 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.001695 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.9036 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.6937 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.06353 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.1259 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.1559 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.4591 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) gene expression 0.007344 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.8955 Moderately Informative Inherited
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 9.494e-06 Informative Direct
Biological Process (BP) positive regulation of gene expression 1.436e-05 Informative Direct
Biological Process (BP) negative regulation of developmental process 0.0005472 Informative Direct
Biological Process (BP) organ morphogenesis 2.647e-08 Informative Direct
Biological Process (BP) sensory organ development 1.529e-07 Informative Direct
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0 Informative Direct
Biological Process (BP) negative regulation of gene expression 0 Informative Direct
Biological Process (BP) negative regulation of biosynthetic process 0 Informative Direct
Biological Process (BP) transcription, DNA-dependent 0 Informative Direct
Biological Process (BP) embryonic morphogenesis 2.192e-13 Informative Direct
Biological Process (BP) leukocyte activation 2.803e-06 Informative Direct
Biological Process (BP) sexual reproduction 0.0002368 Informative Direct
Biological Process (BP) hematopoietic or lymphoid organ development 0.0002518 Informative Direct
Biological Process (BP) multicellular organismal reproductive process 0.0004083 Informative Direct
Biological Process (BP) embryonic organ development 0.000414 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 1 Informative Inherited
Biological Process (BP) regulation of apoptotic signaling pathway 0.05739 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) regulation of cell proliferation 1 Informative Inherited
Biological Process (BP) regulation of growth 1 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) negative regulation of cell death 1 Informative Inherited
Biological Process (BP) protein localization to organelle 1 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.08916 Informative Inherited
Biological Process (BP) response to lipid 0.8254 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.1033 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) growth 0.4279 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.02146 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.521 Informative Inherited
Biological Process (BP) cation homeostasis 1 Informative Inherited
Biological Process (BP) positive regulation of immune system process 1 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.1927 Informative Inherited
Biological Process (BP) response to inorganic substance 0.679 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 1 Informative Inherited
Biological Process (BP) negative regulation of transport 1 Informative Inherited
Biological Process (BP) regulation of secretion 1 Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) regulation of immune effector process 1 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) negative regulation of immune system process 1 Informative Inherited
Biological Process (BP) regulation of cell activation 0.08151 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 1 Informative Inherited
Biological Process (BP) muscle tissue development 0.9763 Informative Inherited
Biological Process (BP) muscle structure development 0.735 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) gland development 0.02639 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) response to hormone stimulus 1 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.005873 Informative Inherited
Biological Process (BP) regulation of cytokine production 1 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.002826 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.05104 Informative Inherited
Biological Process (BP) locomotion 0.4541 Informative Inherited
Biological Process (BP) single-organism behavior 0.8554 Informative Inherited
Biological Process (BP) response to nutrient levels 0.6071 Informative Inherited
Biological Process (BP) central nervous system development 0.1493 Informative Inherited
Biological Process (BP) cell projection organization 0.2282 Informative Inherited
Biological Process (BP) DNA metabolic process 1 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 1 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.9708 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) chromosome organization 0.001681 Informative Inherited
Biological Process (BP) protein modification by small protein conjugation or removal 1 Informative Inherited
Biological Process (BP) single organism reproductive process 0.004147 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.1236 Informative Inherited
Biological Process (BP) epithelium development 0.875 Informative Inherited
Biological Process (BP) cardiovascular system development 0.6154 Informative Inherited
Biological Process (BP) immune response 1 Informative Inherited
Biological Process (BP) response to wounding 1 Informative Inherited
Biological Process (BP) defense response 1 Informative Inherited
Biological Process (BP) generation of neurons 0.761 Informative Inherited
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) regulation of cell development 1 Informative Inherited
Biological Process (BP) localization of cell 0.1699 Informative Inherited
Biological Process (BP) cellular component movement 0.5549 Informative Inherited
Biological Process (BP) tube development 0.003388 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.2284 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.03543 Informative Inherited
Biological Process (BP) mesenchyme development 1.75e-05 Highly Informative Direct
Biological Process (BP) regulation of leukocyte differentiation 0 Highly Informative Direct
Biological Process (BP) negative regulation of transcription, DNA-dependent 0 Highly Informative Direct
Biological Process (BP) renal system development 3.826e-10 Highly Informative Direct
Biological Process (BP) stem cell development 7.809e-09 Highly Informative Direct
Biological Process (BP) pattern specification process 2.174e-08 Highly Informative Direct
Biological Process (BP) neural tube development 1.05e-06 Highly Informative Direct
Biological Process (BP) erythrocyte differentiation 2.118e-06 Highly Informative Direct
Biological Process (BP) post-embryonic development 6.048e-06 Highly Informative Direct
Biological Process (BP) post-embryonic organ development 6.808e-06 Highly Informative Direct
Biological Process (BP) neural precursor cell proliferation 6.933e-06 Highly Informative Direct
Biological Process (BP) regulation of neural precursor cell proliferation 2.303e-05 Highly Informative Direct
Biological Process (BP) regulation of myeloid cell differentiation 2.468e-05 Highly Informative Direct
Biological Process (BP) gonad development 3.154e-05 Highly Informative Direct
Biological Process (BP) myeloid cell development 3.587e-05 Highly Informative Direct
Biological Process (BP) cell fate commitment 3.76e-05 Highly Informative Direct
Biological Process (BP) T cell differentiation 3.879e-05 Highly Informative Direct
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.0001934 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0.0003188 Highly Informative Direct
Biological Process (BP) regulation of steroid biosynthetic process 0.0005954 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 1 Highly Informative Inherited
Biological Process (BP) negative regulation of lipid biosynthetic process 0.8165 Highly Informative Inherited
Biological Process (BP) regulation of intrinsic apoptotic signaling pathway 0.0832 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic signaling pathway 0.8833 Highly Informative Inherited
Biological Process (BP) positive regulation of apoptotic signaling pathway 0.001603 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 1 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.007138 Highly Informative Inherited
Biological Process (BP) regulation of response to nutrient levels 1 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic process 1 Highly Informative Inherited
Biological Process (BP) regulation of cell adhesion 1 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 0.9449 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.4033 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 0.3027 Highly Informative Inherited
Biological Process (BP) response to cold 0.6822 Highly Informative Inherited
Biological Process (BP) ear development 1 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 1 Highly Informative Inherited
Biological Process (BP) cardiac muscle tissue development 0.9947 Highly Informative Inherited
Biological Process (BP) cardiocyte differentiation 1 Highly Informative Inherited
Biological Process (BP) developmental growth 1 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.6578 Highly Informative Inherited
Biological Process (BP) transition metal ion homeostasis 0.5002 Highly Informative Inherited
Biological Process (BP) modification of morphology or physiology of other organism involved in symbiotic interaction 0.04434 Highly Informative Inherited
Biological Process (BP) protein localization to nucleus 0.1226 Highly Informative Inherited
Biological Process (BP) positive regulation of cell activation 0.4589 Highly Informative Inherited
Biological Process (BP) neuron projection development 0.001666 Highly Informative Inherited
Biological Process (BP) cell part morphogenesis 0.6507 Highly Informative Inherited
Biological Process (BP) regulation of adaptive immune response based on somatic recombination of immune receptors built from 0.392 Highly Informative Inherited
Biological Process (BP) negative regulation of leukocyte activation 0.08678 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 1 Highly Informative Inherited
Biological Process (BP) negative regulation of immune effector process 0.02833 Highly Informative Inherited
Biological Process (BP) regulation of production of molecular mediator of immune response 0.4751 Highly Informative Inherited
Biological Process (BP) regulation of hormone secretion 0.7963 Highly Informative Inherited
Biological Process (BP) regulation of peptide transport 0.598 Highly Informative Inherited
Biological Process (BP) negative regulation of secretion 0.573 Highly Informative Inherited
Biological Process (BP) regulation of organ morphogenesis 0.2138 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.003883 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.1297 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.4057 Highly Informative Inherited
Biological Process (BP) multi-organism cellular process 0.09012 Highly Informative Inherited
Biological Process (BP) regulation of binding 0.1884 Highly Informative Inherited
Biological Process (BP) regulation of multicellular organism growth 0.009392 Highly Informative Inherited
Biological Process (BP) limb morphogenesis 0.1265 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.8976 Highly Informative Inherited
Biological Process (BP) response to alcohol 1 Highly Informative Inherited
Biological Process (BP) DNA recombination 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 1 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 1 Highly Informative Inherited
Biological Process (BP) negative regulation of hormone metabolic process 0.0768 Highly Informative Inherited
Biological Process (BP) regulation of cellular ketone metabolic process 1 Highly Informative Inherited
Biological Process (BP) locomotory behavior 1 Highly Informative Inherited
Biological Process (BP) B cell activation 0.00105 Highly Informative Inherited
Biological Process (BP) regulation of exocytosis 0.3065 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 1 Highly Informative Inherited
Biological Process (BP) histone modification 0.01432 Highly Informative Inherited
Biological Process (BP) protein ubiquitination 1 Highly Informative Inherited
Biological Process (BP) respiratory system development 0.01413 Highly Informative Inherited
Biological Process (BP) regulation of gene expression, epigenetic 1 Highly Informative Inherited
Biological Process (BP) endocrine system development 0.02265 Highly Informative Inherited
Biological Process (BP) negative regulation of immune response 0.072 Highly Informative Inherited
Biological Process (BP) inflammatory response 0.363 Highly Informative Inherited
Biological Process (BP) positive regulation of neurogenesis 1 Highly Informative Inherited
Biological Process (BP) leukocyte homeostasis 0.003443 Highly Informative Inherited
Biological Process (BP) branching morphogenesis of an epithelial tube 1 Highly Informative Inherited
Molecular Function (MF) binding 1.036e-11 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) nucleic acid binding 0 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) cation binding 0.3615 Moderately Informative Inherited
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) chromatin binding 0 Informative Direct
Molecular Function (MF) nucleic acid binding transcription factor activity 0 Informative Direct
Molecular Function (MF) zinc ion binding 0 Informative Direct
Molecular Function (MF) nucleotidyltransferase activity 1 Informative Inherited
Molecular Function (MF) protein dimerization activity 0.2544 Informative Inherited
Molecular Function (MF) enzyme binding 1 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) inorganic cation transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) RNA binding 1 Informative Inherited
Molecular Function (MF) sequence-specific DNA binding transcription factor activity 0 Highly Informative Direct
Molecular Function (MF) transcription factor binding 2.284e-08 Highly Informative Direct
Molecular Function (MF) protein heterodimerization activity 0.0007049 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.6075 Highly Informative Inherited
Molecular Function (MF) structure-specific DNA binding 1 Highly Informative Inherited
Molecular Function (MF) ion gated channel activity 1 Highly Informative Inherited
Molecular Function (MF) cation channel activity 1 Highly Informative Inherited
Molecular Function (MF) transcription factor binding transcription factor activity 0.02744 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.2953 Moderately Informative Inherited
Cellular Component (CC) ribonucleoprotein complex 1 Moderately Informative Inherited
Cellular Component (CC) chromosome 2.136e-07 Informative Direct
Cellular Component (CC) nucleoplasm part 0.09691 Informative Inherited
Cellular Component (CC) nuclear body 0.0002382 Highly Informative Direct
Cellular Component (CC) chromatin 0.02148 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring one-carbon groups0.0001316Least InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0.0006257Least InformativeDirect
Enzyme Commission (EC)Methyltransferases3.713e-10Moderately InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase1.404e-15InformativeDirect
Enzyme Commission (EC)RNA uridylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Polynucleotide adenylyltransferase2.368e-16Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0.001264Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.8679Least InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.004648Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.04826Moderately InformativeInherited
Mammalian Phenotype (MP)preweaning lethality0.2344Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryogenesis/ development1Moderately InformativeInherited
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.02271InformativeInherited
Mammalian Phenotype (MP)abnormal neural tube morphology/development0.3983InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.001305Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant1Least InformativeInherited
Worm Phenotype (WP)organism segment morphology variant6.849e-06Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant1.901e-05Moderately InformativeDirect
Worm Phenotype (WP)chemical response variant0.8802Moderately InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant1Moderately InformativeInherited
Worm Phenotype (WP)somatic gonad development variant1.549e-05InformativeDirect
Worm Phenotype (WP)male morphology variant0.0001141InformativeDirect
Worm Phenotype (WP)protruding vulva0.0004198InformativeDirect
Worm Phenotype (WP)sensillum morphology variant0.1617InformativeInherited
Worm Phenotype (WP)drug resistant0.2286InformativeInherited
Worm Phenotype (WP)egg laying variant0.3289InformativeInherited
Worm Phenotype (WP)cell migration variant0.3294InformativeInherited
Worm Phenotype (WP)protein expression variant0.4563InformativeInherited
Worm Phenotype (WP)lineage variant0.0001944Highly InformativeDirect
Worm Phenotype (WP)male tail development variant0.0005854Highly InformativeDirect
Worm Phenotype (WP)neuron migration variant0.01225Highly InformativeInherited
Worm Phenotype (WP)alimentary system morphology variant0.05746Highly InformativeInherited
Worm Phenotype (WP)antibody staining variant0.06336Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0.04828Least InformativeInherited
Fly Anatomy (FA)cell0.7327Least InformativeInherited
Fly Anatomy (FA)neuron0.4724Moderately InformativeInherited

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.726Least InformativeInherited
Xenopus ANatomical entity (XAN)portion of tissue1Least InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.3763Moderately InformativeInherited
Xenopus ANatomical entity (XAN)neural plate0.0268InformativeInherited
Xenopus ANatomical entity (XAN)neural plate border6.361e-05Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)shoot axis0.7764Least InformativeInherited
Plant ANatomical entity (PAN)root system1Least InformativeInherited
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure1Least InformativeInherited
Plant ANatomical entity (PAN)root tip0.0003645InformativeDirect
Plant ANatomical entity (PAN)reproductive shoot apex0.0002397Highly InformativeDirect
Plant ANatomical entity (PAN)primary root0.0004564Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups0.001545Moderately InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0.002064Moderately InformativeInherited
Enzyme Commission (EC)Acyltransferases0.05697Moderately InformativeInherited
Enzyme Commission (EC)Histone-lysine N-methyltransferase7.245e-16InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase2.011e-11InformativeDirect
Enzyme Commission (EC)RNA uridylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Polynucleotide adenylyltransferase9.63e-16Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0Moderately InformativeDirect
Biological processTranscription regulation0Moderately InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processWnt signaling pathway0.0002975InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentSpliceosome1.19e-05InformativeDirect
Coding sequence diversityPolymorphism0Moderately InformativeDirect
DiseaseTumor suppressor0.0004936Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainZinc-finger0Moderately InformativeDirect
Molecular functionDNA-binding0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationRepressor0Moderately InformativeDirect
Post-translational modificationChromatin regulator2.202e-15InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation1.605e-05Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein sumoylation2.983e-09Highly InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 91 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a beta-beta-alpha zinc fingers domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 91 hidden Markov models representing the beta-beta-alpha zinc fingers superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]