SUPERFAMILY 1.75 HMM library and genome assignments server

GLA-domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   GLA-domain [ 57629]
Superfamily:   GLA-domain [ 57630]
Families:   GLA-domain [ 57631] (6)


Superfamily statistics
Genomes (72) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,074 1,300 18
Proteins 1,073 1,294 18


Functional annotation
General category General
Detailed category General

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0.00000000009259 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.000001533 Least Informative Direct
Biological Process (BP) protein metabolic process 0.0000351 Least Informative Direct
Biological Process (BP) positive regulation of biological process 0.000155 Least Informative Direct
Biological Process (BP) localization 0.2807 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.586 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.02228 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of biological quality 0 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.0000000000001147 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 0.00000000001224 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.00000001697 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.0000004244 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.0000004404 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.000004224 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.00000917 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0.00001553 Moderately Informative Direct
Biological Process (BP) regulation of phosphorus metabolic process 0.00001856 Moderately Informative Direct
Biological Process (BP) immune system process 0.00002906 Moderately Informative Direct
Biological Process (BP) organic substance transport 0.00005002 Moderately Informative Direct
Biological Process (BP) cellular component biogenesis 0.00005207 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.00006578 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.0001656 Moderately Informative Direct
Biological Process (BP) cellular localization 0.0002538 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.0003477 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.003693 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.1049 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.005496 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.069 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.003708 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.08239 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.00832 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.009009 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.7729 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.09972 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.01309 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.005155 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.5457 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.1143 Moderately Informative Inherited
Biological Process (BP) negative regulation of protein processing 0 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0 Informative Direct
Biological Process (BP) regulation of body fluid levels 0 Informative Direct
Biological Process (BP) regulation of response to wounding 0 Informative Direct
Biological Process (BP) response to nutrient levels 0.0000000000002478 Informative Direct
Biological Process (BP) blood circulation 0.0000000000002522 Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0.0000000000004604 Informative Direct
Biological Process (BP) regulation of cell activation 0.000000000003314 Informative Direct
Biological Process (BP) negative regulation of cellular protein metabolic process 0.00000000001093 Informative Direct
Biological Process (BP) negative regulation of cell death 0.00000000002145 Informative Direct
Biological Process (BP) negative regulation of catalytic activity 0.00000000004244 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.00000000005665 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.0000000001115 Informative Direct
Biological Process (BP) localization of cell 0.000000000119 Informative Direct
Biological Process (BP) apoptotic process 0.000000003485 Informative Direct
Biological Process (BP) single-organism membrane organization 0.000000004552 Informative Direct
Biological Process (BP) biological adhesion 0.0000000055 Informative Direct
Biological Process (BP) negative regulation of transport 0.000000007211 Informative Direct
Biological Process (BP) regulation of protein phosphorylation 0.000000008444 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0.00000001232 Informative Direct
Biological Process (BP) single-organism cellular localization 0.00000003734 Informative Direct
Biological Process (BP) protein transport 0.00000004283 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 0.00000004779 Informative Direct
Biological Process (BP) regulation of peptidase activity 0.00000007852 Informative Direct
Biological Process (BP) cellular component movement 0.000000103 Informative Direct
Biological Process (BP) cellular response to external stimulus 0.0000001091 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 0.0000003285 Informative Direct
Biological Process (BP) positive regulation of transport 0.0000003945 Informative Direct
Biological Process (BP) regulation of intracellular transport 0.0000007896 Informative Direct
Biological Process (BP) regulation of cell proliferation 0.0000008778 Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.000001049 Informative Direct
Biological Process (BP) locomotion 0.000001059 Informative Direct
Biological Process (BP) single-organism intracellular transport 0.000003205 Informative Direct
Biological Process (BP) positive regulation of intracellular signal transduction 0.000004383 Informative Direct
Biological Process (BP) intracellular signal transduction 0.000008029 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.000008163 Informative Direct
Biological Process (BP) negative regulation of developmental process 0.00001052 Informative Direct
Biological Process (BP) response to cytokine 0.00001083 Informative Direct
Biological Process (BP) phosphorylation 0.00001294 Informative Direct
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.00001487 Informative Direct
Biological Process (BP) negative regulation of biosynthetic process 0.00002752 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.00002763 Informative Direct
Biological Process (BP) regulation of transferase activity 0.00006387 Informative Direct
Biological Process (BP) positive regulation of immune system process 0.0001206 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.0001254 Informative Direct
Biological Process (BP) regulation of secretion 0.000223 Informative Direct
Biological Process (BP) regulation of protein localization 0.0002814 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.0005687 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0.0006873 Informative Direct
Biological Process (BP) regulation of system process 0.002603 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.00105 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.005437 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.003631 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.001381 Informative Inherited
Biological Process (BP) negative regulation of protein transport 0 Highly Informative Direct
Biological Process (BP) negative regulation of endopeptidase activity 0 Highly Informative Direct
Biological Process (BP) coagulation 0 Highly Informative Direct
Biological Process (BP) plasma membrane organization 0 Highly Informative Direct
Biological Process (BP) leukocyte migration 0 Highly Informative Direct
Biological Process (BP) regulation of protein targeting 0 Highly Informative Direct
Biological Process (BP) wound healing 0 Highly Informative Direct
Biological Process (BP) regulation of cytokine secretion 0 Highly Informative Direct
Biological Process (BP) membrane fusion 0.000000000000003707 Highly Informative Direct
Biological Process (BP) negative regulation of sequence-specific DNA binding transcription factor activity 0.00000000000001246 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0.0000000000001039 Highly Informative Direct
Biological Process (BP) negative regulation of secretion by cell 0.00000000000011 Highly Informative Direct
Biological Process (BP) multi-organism cellular process 0.0000000000006491 Highly Informative Direct
Biological Process (BP) phagocytosis 0.000000000001192 Highly Informative Direct
Biological Process (BP) protein localization to membrane 0.000000000001277 Highly Informative Direct
Biological Process (BP) regulation of endocytosis 0.000000000001781 Highly Informative Direct
Biological Process (BP) regulation of leukocyte differentiation 0.000000000001883 Highly Informative Direct
Biological Process (BP) positive regulation of cell activation 0.000000000006388 Highly Informative Direct
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.00000000002696 Highly Informative Direct
Biological Process (BP) post-translational protein modification 0.000000001202 Highly Informative Direct
Biological Process (BP) positive regulation of response to wounding 0.00000000169 Highly Informative Direct
Biological Process (BP) response to carbohydrate 0.000000001776 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 0.000000003996 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular transport 0.000000004263 Highly Informative Direct
Biological Process (BP) regulation of protein localization to nucleus 0.000000004926 Highly Informative Direct
Biological Process (BP) response to drug 0.000000009492 Highly Informative Direct
Biological Process (BP) regulation of wound healing 0.000000009927 Highly Informative Direct
Biological Process (BP) multi-organism behavior 0.00000001524 Highly Informative Direct
Biological Process (BP) modification of morphology or physiology of other organism 0.00000002725 Highly Informative Direct
Biological Process (BP) regulation of peptidyl-tyrosine phosphorylation 0.00000003129 Highly Informative Direct
Biological Process (BP) regulation of cysteine-type endopeptidase activity involved in apoptotic process 0.00000003316 Highly Informative Direct
Biological Process (BP) positive regulation of intracellular transport 0.00000006402 Highly Informative Direct
Biological Process (BP) regulation of blood pressure 0.0000002868 Highly Informative Direct
Biological Process (BP) negative regulation of cytokine production 0.0000004398 Highly Informative Direct
Biological Process (BP) chemotaxis 0.00000555 Highly Informative Direct
Biological Process (BP) peptidyl-serine modification 0.00001303 Highly Informative Direct
Biological Process (BP) negative regulation of transcription, DNA-templated 0.00003796 Highly Informative Direct
Biological Process (BP) ossification 0.00006931 Highly Informative Direct
Biological Process (BP) regulation of nucleocytoplasmic transport 0.0002327 Highly Informative Direct
Biological Process (BP) negative regulation of coagulation 0.0004111 Highly Informative Direct
Biological Process (BP) positive regulation of protein kinase activity 0.000589 Highly Informative Direct
Biological Process (BP) protein phosphorylation 0.003937 Highly Informative Inherited
Biological Process (BP) hemostasis 0.2214 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0.00000000003423 Least Informative Direct
Molecular Function (MF) binding 0.02914 Least Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.0000000008239 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.0000001514 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0.000004833 Moderately Informative Direct
Molecular Function (MF) transporter activity 0.0000325 Moderately Informative Direct
Molecular Function (MF) anion binding 0.1679 Moderately Informative Inherited
Molecular Function (MF) cation binding 1 Moderately Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 0 Informative Direct
Molecular Function (MF) peptidase activity 0 Informative Direct
Molecular Function (MF) peptidase regulator activity 0 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0.00000000001476 Informative Direct
Molecular Function (MF) lipid binding 0.00000000008923 Informative Direct
Molecular Function (MF) carboxylic acid binding 0.0000000002681 Informative Direct
Molecular Function (MF) receptor binding 0.000000009707 Informative Direct
Molecular Function (MF) enzyme activator activity 0.0002929 Informative Direct
Molecular Function (MF) protein kinase regulator activity 0 Highly Informative Direct
Molecular Function (MF) serine hydrolase activity 0 Highly Informative Direct
Molecular Function (MF) amino acid binding 0 Highly Informative Direct
Molecular Function (MF) calcium ion transmembrane transporter activity 8.141e-16 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 0.000000000000006187 Highly Informative Direct
Molecular Function (MF) cation channel activity 0.000000000001219 Highly Informative Direct
Molecular Function (MF) gated channel activity 0.00000000000238 Highly Informative Direct
Molecular Function (MF) endopeptidase activity 0.000007683 Highly Informative Direct
Molecular Function (MF) calcium ion binding 0.00001183 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase inhibitor activity 0.00002426 Highly Informative Direct
Cellular Component (CC) intracellular organelle part 0.9622 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) extracellular region part 0.000000000000003071 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 0.000005524 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0.0484 Moderately Informative Inherited
Cellular Component (CC) extracellular matrix 0.000008027 Informative Direct
Cellular Component (CC) Golgi apparatus 0.000009557 Informative Direct
Cellular Component (CC) extracellular space 0.0001243 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 0.0005542 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0Moderately InformativeDirect
Enzyme Commission (EC)Coagulation factor Xa0Highly InformativeDirect
Enzyme Commission (EC)Coagulation factor IXa0.00000000005175Highly InformativeDirect
Enzyme Commission (EC)Protein C (activated)0.0000000008721Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.004198Least InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.0000001182Moderately InformativeDirect
Disease Ontology (DO)urinary system disease0.0002213Moderately InformativeDirect
Disease Ontology (DO)syndrome0.0008591Moderately InformativeDirect
Disease Ontology (DO)endocrine system disease0.00602Moderately InformativeInherited
Disease Ontology (DO)artery disease0.45Moderately InformativeInherited
Disease Ontology (DO)atherosclerosis0.0000217InformativeDirect
Disease Ontology (DO)coronary artery disease0.04659InformativeInherited
Disease Ontology (DO)pancreas disease0.1224InformativeInherited
Disease Ontology (DO)inherited blood coagulation disease0.0000129Highly InformativeDirect
Disease Ontology (DO)Behcet's disease0.00004154Highly InformativeDirect
Disease Ontology (DO)pancreatitis0.0001468Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.1084Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.1486Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.001266Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.00999Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of brain morphology0.03795Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0.06501Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.102Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal genital system morphology0.1244Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal bleeding0.0000002923InformativeDirect
Phenotypic Abnormality (PA)Puberty and gonadal disorders0.00596InformativeInherited
Phenotypic Abnormality (PA)Abnormality of female internal genitalia0.01642InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system physiology0.1213InformativeInherited
Phenotypic Abnormality (PA)Deep venous thrombosis0.0000000001944Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of coagulation0.000000008463Highly InformativeDirect
Phenotypic Abnormality (PA)Joint hemorrhage0.0000005029Highly InformativeDirect
Phenotypic Abnormality (PA)Pulmonary embolism0.000001651Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the cerebral vasculature0.0001606Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.0005021Least InformativeDirect
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.00001944Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal heart morphology0.2463Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.8357Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation0.0000000002677InformativeDirect
Mammalian Phenotype (MP)hemorrhage0.0000002762InformativeDirect
Mammalian Phenotype (MP)fibrosis0.01735InformativeInherited
Mammalian Phenotype (MP)abnormal bone structure0.04145InformativeInherited
Mammalian Phenotype (MP)cardiac fibrosis0.000668Highly InformativeDirect
Mammalian Phenotype (MP)abnormal trabecular bone morphology0.00444Highly InformativeInherited

Document: MP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0InformativeDirect

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)blood and blood forming organs0Least InformativeDirect
Drugbank ATC_code (DB)cardiovascular system0.06923Least InformativeInherited
Drugbank ATC_code (DB)vasoprotectives0.0002114Moderately InformativeDirect
Drugbank ATC_code (DB)vitamin k and other hemostatics0InformativeDirect
Drugbank ATC_code (DB)antivaricose therapy0.00001114InformativeDirect
Drugbank ATC_code (DB)vitamin k0Highly InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0.0000000008322Moderately InformativeDirect
Biological processHemostasis0InformativeDirect
Biological processOsteogenesis0Highly InformativeDirect
Biological processAcute phase0.0000000000003012Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Coding sequence diversityPolymorphism0.00001852Moderately InformativeDirect
DomainSignal0Least InformativeDirect
DomainRepeat0.00000000007743Least InformativeDirect
DomainEGF-like domain0InformativeDirect
DomainKringle0.00000000001538Highly InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Post-translational modificationHydrolase0.0000000000000872Least InformativeDirect
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.00000009426Moderately InformativeDirect
Post-translational modificationSerine protease0InformativeDirect
Post-translational modificationToxin0.000000000272InformativeDirect
Post-translational modificationHemostasis impairing toxin0.000000005192Highly InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationGlycoprotein0.00000007728Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues0Moderately InformativeDirect
Post-translational modificationHydroxylation0InformativeDirect
Post-translational modificationZymogen0InformativeDirect
Post-translational modificationSulfation0.0000002762InformativeDirect
Post-translational modificationGamma-carboxyglutamic acid0Highly InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000294 SSF57630 Protein matches
Abstract

This domain contains post-translational modifications of many glutamate residues by vitamin K-dependent carboxylation to form gamma-carboxyglutamate (Gla) [PubMed3106112, PubMed2183788]. The GLA domain is responsible for the high-affinity binding of calcium ions. It starts at the N-terminal extremity of the mature form of proteins and ends with a conserved aromatic residue; a conserved Gla-x(3)-Gla-x-Cys motif [PubMed3317405] is found in the middle of the domain which seems to be important for substrate recognition by the carboxylase.

The 3D structure of the Gla domain has been solved [PubMed7713897, PubMed8663165]. Calcium ions induce conformational changes in the Gla domain and are necessary for the Gla domain to fold properly. A common structural feature of functional Gla domains is the clustering of N-terminal hydrophobic residues into a hydrophobic patch that mediates interaction with the cell surface membrane [PubMed8663165].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 9 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a GLA-domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 9 hidden Markov models representing the GLA-domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · Internal database links ]