SUPERFAMILY 1.75 HMM library and genome assignments server


GLA-domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   GLA-domain [ 57629]
Superfamily:   GLA-domain [ 57630]
Families:   GLA-domain [ 57631] (6)


Superfamily statistics
Genomes (65) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 969 1,128 18
Proteins 969 1,127 18


Functional annotation
General category General
Detailed category General

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 2.404e-09 Least Informative Direct
Biological Process (BP) multicellular organismal process 6.365e-06 Least Informative Direct
Biological Process (BP) protein metabolic process 0.0003106 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.7457 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 0.2788 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.9467 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.04519 Least Informative Inherited
Biological Process (BP) regulation of response to stimulus 6.117e-14 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 1.937e-13 Moderately Informative Direct
Biological Process (BP) multi-organism process 5.203e-12 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 2.26e-07 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 4.867e-07 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 2.427e-06 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 2.878e-06 Moderately Informative Direct
Biological Process (BP) response to organic substance 3.003e-06 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 3.933e-06 Moderately Informative Direct
Biological Process (BP) immune system process 2.381e-05 Moderately Informative Direct
Biological Process (BP) regulation of localization 2.95e-05 Moderately Informative Direct
Biological Process (BP) organic substance transport 0.000106 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.0001336 Moderately Informative Direct
Biological Process (BP) cellular component biogenesis 0.0002477 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.0003336 Moderately Informative Direct
Biological Process (BP) cellular localization 0.0003625 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.001835 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.05424 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 0.3479 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.06807 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 0.6823 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.0566 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.1654 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 0.1092 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.01128 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.00113 Moderately Informative Inherited
Biological Process (BP) reproduction 0.01103 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.008017 Moderately Informative Inherited
Biological Process (BP) system process 0.1221 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.00135 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.387 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of body fluid levels 0 Informative Direct
Biological Process (BP) response to wounding 0 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0 Informative Direct
Biological Process (BP) negative regulation of cell death 1.808e-13 Informative Direct
Biological Process (BP) blood circulation 6.235e-13 Informative Direct
Biological Process (BP) positive regulation of signal transduction 2.607e-12 Informative Direct
Biological Process (BP) regulation of apoptotic process 2.243e-11 Informative Direct
Biological Process (BP) multi-organism reproductive process 3.385e-11 Informative Direct
Biological Process (BP) negative regulation of molecular function 1.994e-10 Informative Direct
Biological Process (BP) localization of cell 2.847e-10 Informative Direct
Biological Process (BP) regulation of response to external stimulus 3.671e-10 Informative Direct
Biological Process (BP) positive regulation of phosphorus metabolic process 7.202e-10 Informative Direct
Biological Process (BP) biological adhesion 1.045e-09 Informative Direct
Biological Process (BP) regulation of hydrolase activity 3.355e-09 Informative Direct
Biological Process (BP) apoptotic process 3.827e-09 Informative Direct
Biological Process (BP) regulation of cell development 4.137e-09 Informative Direct
Biological Process (BP) regulation of protein phosphorylation 8.288e-09 Informative Direct
Biological Process (BP) cellular component movement 1.138e-08 Informative Direct
Biological Process (BP) cellular membrane organization 1.788e-08 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 6.747e-08 Informative Direct
Biological Process (BP) protein transport 1.244e-07 Informative Direct
Biological Process (BP) positive regulation of protein metabolic process 2.561e-07 Informative Direct
Biological Process (BP) positive regulation of transport 2.83e-07 Informative Direct
Biological Process (BP) regulation of intracellular transport 5.134e-07 Informative Direct
Biological Process (BP) regulation of cell proliferation 5.793e-07 Informative Direct
Biological Process (BP) locomotion 1.377e-06 Informative Direct
Biological Process (BP) cellular process involved in reproduction 1.636e-06 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 3.142e-06 Informative Direct
Biological Process (BP) response to cytokine stimulus 3.334e-06 Informative Direct
Biological Process (BP) negative regulation of developmental process 3.45e-06 Informative Direct
Biological Process (BP) intracellular signal transduction 6.267e-06 Informative Direct
Biological Process (BP) negative regulation of nitrogen compound metabolic process 1.54e-05 Informative Direct
Biological Process (BP) vesicle-mediated transport 2.147e-05 Informative Direct
Biological Process (BP) negative regulation of biosynthetic process 2.895e-05 Informative Direct
Biological Process (BP) negative regulation of cell communication 6.679e-05 Informative Direct
Biological Process (BP) positive regulation of immune system process 0.0001135 Informative Direct
Biological Process (BP) negative regulation of cellular metabolic process 0.0001555 Informative Direct
Biological Process (BP) negative regulation of signaling 0.0001897 Informative Direct
Biological Process (BP) regulation of protein localization 0.0002906 Informative Direct
Biological Process (BP) regulation of secretion 0.0003186 Informative Direct
Biological Process (BP) regulation of intracellular protein kinase cascade 0.0004163 Informative Direct
Biological Process (BP) regulation of system process 0.05634 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.002851 Informative Inherited
Biological Process (BP) regulation of response to stress 0.004006 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.002543 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.001925 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.0265 Informative Inherited
Biological Process (BP) protein phosphorylation 0.0128 Informative Inherited
Biological Process (BP) response to external stimulus 0.002997 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.01605 Informative Inherited
Biological Process (BP) negative regulation of protein transport 0 Highly Informative Direct
Biological Process (BP) protein localization to membrane 0 Highly Informative Direct
Biological Process (BP) negative regulation of endopeptidase activity 0 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic process 0 Highly Informative Direct
Biological Process (BP) leukocyte migration 0 Highly Informative Direct
Biological Process (BP) regulation of interleukin-1 production 0 Highly Informative Direct
Biological Process (BP) plasma membrane organization 0 Highly Informative Direct
Biological Process (BP) coagulation 0 Highly Informative Direct
Biological Process (BP) positive regulation of protein kinase B signaling cascade 0 Highly Informative Direct
Biological Process (BP) wound healing 0 Highly Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 4.735e-14 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 6.802e-14 Highly Informative Direct
Biological Process (BP) activation of protein kinase activity 1.086e-13 Highly Informative Direct
Biological Process (BP) multi-organism cellular process 2.516e-13 Highly Informative Direct
Biological Process (BP) regulation of lymphocyte activation 2.091e-12 Highly Informative Direct
Biological Process (BP) regulation of blood coagulation 2.589e-12 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 3.288e-12 Highly Informative Direct
Biological Process (BP) phagocytosis 3.298e-12 Highly Informative Direct
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 4.761e-12 Highly Informative Direct
Biological Process (BP) regulation of leukocyte differentiation 1.235e-11 Highly Informative Direct
Biological Process (BP) positive regulation of cell activation 6.595e-11 Highly Informative Direct
Biological Process (BP) negative regulation of sequence-specific DNA binding transcription factor activity 1.261e-10 Highly Informative Direct
Biological Process (BP) post-translational protein modification 1.069e-09 Highly Informative Direct
Biological Process (BP) response to carbohydrate stimulus 1.138e-09 Highly Informative Direct
Biological Process (BP) response to drug 5.045e-09 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular transport 7.081e-09 Highly Informative Direct
Biological Process (BP) multi-organism behavior 1.258e-08 Highly Informative Direct
Biological Process (BP) regulation of protein localization to nucleus 1.607e-08 Highly Informative Direct
Biological Process (BP) positive regulation of intracellular transport 2.633e-08 Highly Informative Direct
Biological Process (BP) modification of morphology or physiology of other organism 2.906e-08 Highly Informative Direct
Biological Process (BP) regulation of peptidyl-tyrosine phosphorylation 3.303e-08 Highly Informative Direct
Biological Process (BP) negative regulation of secretion 6.354e-08 Highly Informative Direct
Biological Process (BP) regulation of cysteine-type endopeptidase activity involved in apoptotic process 8.128e-08 Highly Informative Direct
Biological Process (BP) regulation of protein secretion 2.418e-07 Highly Informative Direct
Biological Process (BP) positive regulation of cell differentiation 3.007e-07 Highly Informative Direct
Biological Process (BP) regulation of blood pressure 5.457e-07 Highly Informative Direct
Biological Process (BP) chemotaxis 2.823e-06 Highly Informative Direct
Biological Process (BP) negative regulation of RNA metabolic process 7.17e-06 Highly Informative Direct
Biological Process (BP) peptidyl-serine modification 1.307e-05 Highly Informative Direct
Biological Process (BP) negative regulation of cellular macromolecule biosynthetic process 1.396e-05 Highly Informative Direct
Biological Process (BP) positive regulation of protein transport 2.918e-05 Highly Informative Direct
Biological Process (BP) ossification 3.938e-05 Highly Informative Direct
Biological Process (BP) regulation of intracellular protein transport 8.477e-05 Highly Informative Direct
Biological Process (BP) negative regulation of gene expression 0.0003843 Highly Informative Direct
Biological Process (BP) regulation of nucleocytoplasmic transport 0.002039 Highly Informative Inherited
Biological Process (BP) hemostasis 0.2564 Highly Informative Inherited
Biological Process (BP) negative regulation of signal transduction 0.002691 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 1.577e-09 Least Informative Direct
Molecular Function (MF) binding 0.04843 Least Informative Inherited
Molecular Function (MF) enzyme regulator activity 2.393e-08 Moderately Informative Direct
Molecular Function (MF) transporter activity 3.806e-05 Moderately Informative Direct
Molecular Function (MF) anion binding 0.1897 Moderately Informative Inherited
Molecular Function (MF) cation binding 1 Moderately Informative Inherited
Molecular Function (MF) protein binding 0.1538 Moderately Informative Inherited
Molecular Function (MF) peptidase activity 0 Informative Direct
Molecular Function (MF) peptidase regulator activity 0 Informative Direct
Molecular Function (MF) enzyme inhibitor activity 3.07e-15 Informative Direct
Molecular Function (MF) lipid binding 4.29e-11 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 4.593e-11 Informative Direct
Molecular Function (MF) carboxylic acid binding 2.434e-10 Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 4.194e-10 Informative Direct
Molecular Function (MF) receptor binding 1.321e-08 Informative Direct
Molecular Function (MF) enzyme activator activity 1.78e-05 Informative Direct
Molecular Function (MF) serine-type peptidase activity 0 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 0 Highly Informative Direct
Molecular Function (MF) protein kinase regulator activity 0 Highly Informative Direct
Molecular Function (MF) modified amino acid binding 0 Highly Informative Direct
Molecular Function (MF) ion gated channel activity 5.182e-12 Highly Informative Direct
Molecular Function (MF) ion channel activity 8.952e-11 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase inhibitor activity 2.357e-06 Highly Informative Direct
Molecular Function (MF) calcium ion binding 1.99e-05 Highly Informative Direct
Molecular Function (MF) endopeptidase activity 5.207e-05 Highly Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) extracellular region 0 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 1.134e-05 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0.1297 Moderately Informative Inherited
Cellular Component (CC) Golgi apparatus 1.434e-06 Informative Direct
Cellular Component (CC) extracellular matrix 0.0001679 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0Moderately InformativeDirect
Enzyme Commission (EC)Coagulation factor Xa0Highly InformativeDirect
Enzyme Commission (EC)Coagulation factor IXa5.175e-11Highly InformativeDirect
Enzyme Commission (EC)Protein C (activated)8.721e-10Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.004387Least InformativeInherited
Disease Ontology (DO)nervous system disease0.1844Least InformativeInherited
Disease Ontology (DO)hematopoietic system disease1.275e-07Moderately InformativeDirect
Disease Ontology (DO)vascular disease1.552e-06Moderately InformativeDirect
Disease Ontology (DO)kidney disease7.067e-06Moderately InformativeDirect
Disease Ontology (DO)brain disease0.0001105Moderately InformativeDirect
Disease Ontology (DO)syndrome0.0008764Moderately InformativeDirect
Disease Ontology (DO)endocrine system disease0.005101Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.04097Moderately InformativeInherited
Disease Ontology (DO)heart disease0.2223Moderately InformativeInherited
Disease Ontology (DO)atherosclerosis2.453e-05InformativeDirect
Disease Ontology (DO)autoimmune disease of cardiovascular system5.217e-05InformativeDirect
Disease Ontology (DO)cerebrovascular disease0.002068InformativeInherited
Disease Ontology (DO)myocardial infarction0.002551InformativeInherited
Disease Ontology (DO)vasculitis0.04887InformativeInherited
Disease Ontology (DO)pancreas disease0.1361InformativeInherited
Disease Ontology (DO)inherited blood coagulation disease7.746e-06Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
ONset and clinical course (ON)Variable expressivity0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.1492Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the central nervous system0.3018Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of head and neck0.3762Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.00127Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.009751Moderately InformativeInherited
Phenotypic Abnormality (PA)Morphological abnormality of the central nervous system0.05408Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.09906Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the respiratory system0.1009Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genital system0.1518Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal bleeding3.358e-07InformativeDirect
Phenotypic Abnormality (PA)Puberty and gonadal disorders0.005739InformativeInherited
Phenotypic Abnormality (PA)Abnormality of female internal genitalia0.01646InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the nose0.05617InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system physiology0.1244InformativeInherited
Phenotypic Abnormality (PA)Deep venous thrombosis2.029e-10Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of coagulation7.757e-09Highly InformativeDirect
Phenotypic Abnormality (PA)Joint hemorrhage3.218e-07Highly InformativeDirect
Phenotypic Abnormality (PA)Pulmonary embolism1.827e-06Highly InformativeDirect
Phenotypic Abnormality (PA)Menorrhagia2.779e-06Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the cerebral vasculature0.0001351Highly InformativeDirect
Phenotypic Abnormality (PA)Epistaxis0.0001884Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.0007498Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.004557Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood homeostasis1.774e-05Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.0003084Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal blood coagulation6.266e-10InformativeDirect
Mammalian Phenotype (MP)hemorrhage3.975e-07InformativeDirect

Document: MP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0InformativeDirect

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)blood and blood forming organs0.0002327Least InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation5.297e-10Moderately InformativeDirect
Biological processHemostasis0InformativeDirect
Biological processOsteogenesis0Highly InformativeDirect
Biological processAcute phase3.298e-13Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Coding sequence diversityPolymorphism2.062e-05Moderately InformativeDirect
DomainSignal0Least InformativeDirect
DomainRepeat8.047e-10Least InformativeDirect
DomainEGF-like domain0InformativeDirect
DomainKringle2.552e-11Highly InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Post-translational modificationHydrolase5.234e-14Least InformativeDirect
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationDevelopmental protein8.099e-08Moderately InformativeDirect
Post-translational modificationSerine protease0InformativeDirect
Post-translational modificationToxin1.693e-10InformativeDirect
Post-translational modificationHemostasis impairing toxin3.139e-09Highly InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationGlycoprotein1.312e-07Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues0Moderately InformativeDirect
Post-translational modificationHydroxylation0InformativeDirect
Post-translational modificationZymogen0InformativeDirect
Post-translational modificationSulfation3.232e-07InformativeDirect
Post-translational modificationGamma-carboxyglutamic acid0Highly InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000294 SSF57630 Protein matches
Abstract

This domain contains post-translational modifications of many glutamate residues by vitamin K-dependent carboxylation to form gamma-carboxyglutamate (Gla) [PubMed3106112, PubMed2183788]. The GLA domain is responsible for the high-affinity binding of calcium ions. It starts at the N-terminal extremity of the mature form of proteins and ends with a conserved aromatic residue; a conserved Gla-x(3)-Gla-x-Cys motif [PubMed3317405] is found in the middle of the domain which seems to be important for substrate recognition by the carboxylase.

The 3D structure of the Gla domain has been solved [PubMed7713897, PubMed8663165]. Calcium ions induce conformational changes in the Gla domain and are necessary for the Gla domain to fold properly. A common structural feature of functional Gla domains is the clustering of N-terminal hydrophobic residues into a hydrophobic patch that mediates interaction with the cell surface membrane [PubMed8663165].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 9 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a GLA-domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 9 hidden Markov models representing the GLA-domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · Internal database links ]