SUPERFAMILY 1.75 HMM library and genome assignments server


GLA-domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   GLA-domain [ 57629]
Superfamily:   GLA-domain [ 57630]
Families:   GLA-domain [ 57631] (6)


Superfamily statistics
Genomes (72) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,074 1,300 18
Proteins 1,073 1,294 18


Functional annotation
General category General
Detailed category General

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 9.403e-11 Least Informative Direct
Biological Process (BP) multicellular organismal process 4.177e-06 Least Informative Direct
Biological Process (BP) protein metabolic process 2.932e-05 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.5436 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.783 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.02187 Least Informative Inherited
Biological Process (BP) localization 0.2524 Least Informative Inherited
Biological Process (BP) regulation of biological quality 0 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 6.828e-13 Moderately Informative Direct
Biological Process (BP) multi-organism process 1.125e-11 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 4.117e-07 Moderately Informative Direct
Biological Process (BP) response to organic substance 4.237e-07 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 2.025e-06 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 3.919e-06 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 4.638e-06 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 1.471e-05 Moderately Informative Direct
Biological Process (BP) immune system process 2.95e-05 Moderately Informative Direct
Biological Process (BP) organic substance transport 4.839e-05 Moderately Informative Direct
Biological Process (BP) cellular component biogenesis 4.878e-05 Moderately Informative Direct
Biological Process (BP) macromolecule localization 9.345e-05 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.0001366 Moderately Informative Direct
Biological Process (BP) cellular localization 0.0002221 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.0003475 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.003708 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.1588 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.1535 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.06111 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.003681 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.008319 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.3414 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.3785 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.06238 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.0496 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.007923 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.004834 Moderately Informative Inherited
Biological Process (BP) reproduction 0.009179 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.009009 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.008267 Moderately Informative Inherited
Biological Process (BP) system process 0.134 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) regulation of body fluid levels 0 Informative Direct
Biological Process (BP) response to wounding 0 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0 Informative Direct
Biological Process (BP) regulation of peptidase activity 7.347e-15 Informative Direct
Biological Process (BP) response to nutrient levels 1.766e-13 Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 1.827e-13 Informative Direct
Biological Process (BP) blood circulation 2.508e-13 Informative Direct
Biological Process (BP) negative regulation of cell death 3.27e-13 Informative Direct
Biological Process (BP) regulation of cell activation 1.786e-12 Informative Direct
Biological Process (BP) negative regulation of catalytic activity 1.107e-11 Informative Direct
Biological Process (BP) positive regulation of signal transduction 1.468e-11 Informative Direct
Biological Process (BP) localization of cell 1.13e-10 Informative Direct
Biological Process (BP) regulation of response to external stimulus 2.544e-10 Informative Direct
Biological Process (BP) cellular membrane organization 3.805e-10 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 6.19e-10 Informative Direct
Biological Process (BP) biological adhesion 6.887e-10 Informative Direct
Biological Process (BP) apoptotic process 3.529e-09 Informative Direct
Biological Process (BP) negative regulation of transport 3.868e-09 Informative Direct
Biological Process (BP) regulation of protein phosphorylation 7.537e-09 Informative Direct
Biological Process (BP) protein transport 4.109e-08 Informative Direct
Biological Process (BP) cellular component movement 1.002e-07 Informative Direct
Biological Process (BP) positive regulation of protein metabolic process 3.16e-07 Informative Direct
Biological Process (BP) regulation of cell proliferation 4.756e-07 Informative Direct
Biological Process (BP) positive regulation of transport 4.821e-07 Informative Direct
Biological Process (BP) regulation of intracellular transport 8.485e-07 Informative Direct
Biological Process (BP) cellular process involved in reproduction 8.626e-07 Informative Direct
Biological Process (BP) locomotion 1.068e-06 Informative Direct
Biological Process (BP) negative regulation of developmental process 2.97e-06 Informative Direct
Biological Process (BP) phosphorylation 3.724e-06 Informative Direct
Biological Process (BP) intracellular signal transduction 4.115e-06 Informative Direct
Biological Process (BP) vesicle-mediated transport 7.854e-06 Informative Direct
Biological Process (BP) negative regulation of nitrogen compound metabolic process 9.257e-06 Informative Direct
Biological Process (BP) response to cytokine stimulus 1.084e-05 Informative Direct
Biological Process (BP) negative regulation of biosynthetic process 1.629e-05 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 2.699e-05 Informative Direct
Biological Process (BP) positive regulation of immune system process 7.865e-05 Informative Direct
Biological Process (BP) regulation of intracellular protein kinase cascade 9.986e-05 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.0001189 Informative Direct
Biological Process (BP) regulation of secretion 0.0002255 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.0002325 Informative Direct
Biological Process (BP) regulation of protein localization 0.0002654 Informative Direct
Biological Process (BP) negative regulation of gene expression 0.0004435 Informative Direct
Biological Process (BP) negative regulation of signaling 0.0006551 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0.000859 Informative Direct
Biological Process (BP) regulation of system process 0.06197 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.01816 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.003718 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.002238 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.03287 Informative Inherited
Biological Process (BP) regulation of coagulation 0 Highly Informative Direct
Biological Process (BP) negative regulation of protein transport 0 Highly Informative Direct
Biological Process (BP) regulation of wound healing 0 Highly Informative Direct
Biological Process (BP) regulation of cytokine secretion 0 Highly Informative Direct
Biological Process (BP) negative regulation of endopeptidase activity 0 Highly Informative Direct
Biological Process (BP) regulation of protein kinase B signaling cascade 0 Highly Informative Direct
Biological Process (BP) leukocyte migration 0 Highly Informative Direct
Biological Process (BP) coagulation 0 Highly Informative Direct
Biological Process (BP) wound healing 0 Highly Informative Direct
Biological Process (BP) regulation of hemostasis 0 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic process 1.938e-15 Highly Informative Direct
Biological Process (BP) membrane fusion 3.755e-15 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 1.083e-13 Highly Informative Direct
Biological Process (BP) interaction with host 1.364e-13 Highly Informative Direct
Biological Process (BP) multi-organism cellular process 4.51e-13 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 7.409e-13 Highly Informative Direct
Biological Process (BP) phagocytosis 1.108e-12 Highly Informative Direct
Biological Process (BP) regulation of leukocyte differentiation 1.78e-12 Highly Informative Direct
Biological Process (BP) regulation of endocytosis 2.864e-12 Highly Informative Direct
Biological Process (BP) positive regulation of cell activation 1.262e-11 Highly Informative Direct
Biological Process (BP) negative regulation of sequence-specific DNA binding transcription factor activity 3.063e-11 Highly Informative Direct
Biological Process (BP) post-translational protein modification 1.201e-09 Highly Informative Direct
Biological Process (BP) response to carbohydrate stimulus 1.75e-09 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular transport 1.912e-09 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 3.658e-09 Highly Informative Direct
Biological Process (BP) regulation of protein localization to nucleus 6.546e-09 Highly Informative Direct
Biological Process (BP) response to drug 1.26e-08 Highly Informative Direct
Biological Process (BP) regulation of peptidyl-tyrosine phosphorylation 1.715e-08 Highly Informative Direct
Biological Process (BP) positive regulation of intracellular transport 2.873e-08 Highly Informative Direct
Biological Process (BP) multi-organism behavior 3.151e-08 Highly Informative Direct
Biological Process (BP) regulation of cysteine-type endopeptidase activity involved in apoptotic process 3.345e-08 Highly Informative Direct
Biological Process (BP) negative regulation of secretion 3.436e-08 Highly Informative Direct
Biological Process (BP) regulation of blood pressure 2.537e-07 Highly Informative Direct
Biological Process (BP) negative regulation of transcription, DNA-dependent 2.517e-06 Highly Informative Direct
Biological Process (BP) chemotaxis 5.606e-06 Highly Informative Direct
Biological Process (BP) peptidyl-serine modification 1.287e-05 Highly Informative Direct
Biological Process (BP) regulation of intracellular protein transport 4.145e-05 Highly Informative Direct
Biological Process (BP) ossification 5.443e-05 Highly Informative Direct
Biological Process (BP) regulation of nucleocytoplasmic transport 0.0002867 Highly Informative Direct
Biological Process (BP) positive regulation of protein kinase activity 0.0005651 Highly Informative Direct
Biological Process (BP) protein phosphorylation 0.006127 Highly Informative Inherited
Biological Process (BP) hemostasis 0.2228 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 3.308e-11 Least Informative Direct
Molecular Function (MF) binding 0.03672 Least Informative Inherited
Molecular Function (MF) enzyme regulator activity 7.981e-09 Moderately Informative Direct
Molecular Function (MF) transporter activity 2.729e-05 Moderately Informative Direct
Molecular Function (MF) anion binding 0.1681 Moderately Informative Inherited
Molecular Function (MF) cation binding 1 Moderately Informative Inherited
Molecular Function (MF) peptidase activity 0 Informative Direct
Molecular Function (MF) peptidase regulator activity 0 Informative Direct
Molecular Function (MF) enzyme inhibitor activity 0 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 1.45e-11 Informative Direct
Molecular Function (MF) lipid binding 5.602e-11 Informative Direct
Molecular Function (MF) carboxylic acid binding 2.572e-10 Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 5.685e-10 Informative Direct
Molecular Function (MF) receptor binding 5.063e-09 Informative Direct
Molecular Function (MF) enzyme activator activity 2.049e-05 Informative Direct
Molecular Function (MF) amino acid binding 0 Highly Informative Direct
Molecular Function (MF) serine hydrolase activity 0 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 0 Highly Informative Direct
Molecular Function (MF) protein kinase regulator activity 0 Highly Informative Direct
Molecular Function (MF) calcium ion transmembrane transporter activity 8.006e-16 Highly Informative Direct
Molecular Function (MF) cation channel activity 1.179e-12 Highly Informative Direct
Molecular Function (MF) ion gated channel activity 2.021e-12 Highly Informative Direct
Molecular Function (MF) endopeptidase activity 7.944e-06 Highly Informative Direct
Molecular Function (MF) calcium ion binding 1.172e-05 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase inhibitor activity 2.395e-05 Highly Informative Direct
Cellular Component (CC) intracellular organelle part 0.9826 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) extracellular region part 3.095e-15 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 5.509e-06 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0.07761 Moderately Informative Inherited
Cellular Component (CC) Golgi apparatus 4.182e-06 Informative Direct
Cellular Component (CC) extracellular matrix 9.305e-06 Informative Direct
Cellular Component (CC) extracellular space 0.000129 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 0.0004985 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0Moderately InformativeDirect
Enzyme Commission (EC)Coagulation factor Xa0Highly InformativeDirect
Enzyme Commission (EC)Coagulation factor IXa5.175e-11Highly InformativeDirect
Enzyme Commission (EC)Protein C (activated)8.721e-10Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.004198Least InformativeInherited
Disease Ontology (DO)hematopoietic system disease1.182e-07Moderately InformativeDirect
Disease Ontology (DO)urinary system disease0.0002213Moderately InformativeDirect
Disease Ontology (DO)syndrome0.0008591Moderately InformativeDirect
Disease Ontology (DO)endocrine system disease0.00602Moderately InformativeInherited
Disease Ontology (DO)artery disease0.45Moderately InformativeInherited
Disease Ontology (DO)atherosclerosis2.17e-05InformativeDirect
Disease Ontology (DO)coronary artery disease0.04659InformativeInherited
Disease Ontology (DO)pancreas disease0.1224InformativeInherited
Disease Ontology (DO)inherited blood coagulation disease1.29e-05Highly InformativeDirect
Disease Ontology (DO)Behcet's disease4.154e-05Highly InformativeDirect
Disease Ontology (DO)pancreatitis0.0001468Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.1084Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.1486Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.001266Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.00999Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of brain morphology0.03795Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0.06501Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.102Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal genital system morphology0.1244Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal bleeding2.923e-07InformativeDirect
Phenotypic Abnormality (PA)Puberty and gonadal disorders0.00596InformativeInherited
Phenotypic Abnormality (PA)Abnormality of female internal genitalia0.01642InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system physiology0.1213InformativeInherited
Phenotypic Abnormality (PA)Deep venous thrombosis1.944e-10Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of coagulation8.463e-09Highly InformativeDirect
Phenotypic Abnormality (PA)Joint hemorrhage5.029e-07Highly InformativeDirect
Phenotypic Abnormality (PA)Pulmonary embolism1.651e-06Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the cerebral vasculature0.0001606Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.0005021Least InformativeDirect
Mammalian Phenotype (MP)abnormal cardiovascular system physiology1.944e-05Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal heart morphology0.2463Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.8357Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation2.677e-10InformativeDirect
Mammalian Phenotype (MP)hemorrhage2.762e-07InformativeDirect
Mammalian Phenotype (MP)fibrosis0.01735InformativeInherited
Mammalian Phenotype (MP)abnormal bone structure0.04145InformativeInherited
Mammalian Phenotype (MP)cardiac fibrosis0.000668Highly InformativeDirect
Mammalian Phenotype (MP)abnormal trabecular bone morphology0.00444Highly InformativeInherited

Document: MP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation8.322e-10Moderately InformativeDirect
Biological processHemostasis0InformativeDirect
Biological processOsteogenesis0Highly InformativeDirect
Biological processAcute phase3.012e-13Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Coding sequence diversityPolymorphism1.852e-05Moderately InformativeDirect
DomainSignal0Least InformativeDirect
DomainRepeat7.743e-11Least InformativeDirect
DomainEGF-like domain0InformativeDirect
DomainKringle1.538e-11Highly InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Post-translational modificationHydrolase8.72e-14Least InformativeDirect
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationDevelopmental protein9.426e-08Moderately InformativeDirect
Post-translational modificationSerine protease0InformativeDirect
Post-translational modificationToxin2.72e-10InformativeDirect
Post-translational modificationHemostasis impairing toxin5.192e-09Highly InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationGlycoprotein7.728e-08Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues0Moderately InformativeDirect
Post-translational modificationHydroxylation0InformativeDirect
Post-translational modificationZymogen0InformativeDirect
Post-translational modificationSulfation2.762e-07InformativeDirect
Post-translational modificationGamma-carboxyglutamic acid0Highly InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000294 SSF57630 Protein matches
Abstract

This domain contains post-translational modifications of many glutamate residues by vitamin K-dependent carboxylation to form gamma-carboxyglutamate (Gla) [PubMed3106112, PubMed2183788]. The GLA domain is responsible for the high-affinity binding of calcium ions. It starts at the N-terminal extremity of the mature form of proteins and ends with a conserved aromatic residue; a conserved Gla-x(3)-Gla-x-Cys motif [PubMed3317405] is found in the middle of the domain which seems to be important for substrate recognition by the carboxylase.

The 3D structure of the Gla domain has been solved [PubMed7713897, PubMed8663165]. Calcium ions induce conformational changes in the Gla domain and are necessary for the Gla domain to fold properly. A common structural feature of functional Gla domains is the clustering of N-terminal hydrophobic residues into a hydrophobic patch that mediates interaction with the cell surface membrane [PubMed8663165].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 9 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a GLA-domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 9 hidden Markov models representing the GLA-domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]