SUPERFAMILY 1.75 HMM library and genome assignments server


Invertebrate chitin-binding proteins superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Invertebrate chitin-binding proteins [ 57624]
Superfamily:   Invertebrate chitin-binding proteins [ 57625] (2)
Families:   Tachycitin [ 57626]
  Antifungal peptide scarabaecin [ 90179]


Superfamily statistics
Genomes (169) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 8,888 0 3
Proteins 3,830 0 3


Functional annotation
General category Metabolism
Detailed category Carbohydrate metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Molecular Function (MF)binding0.0032442.636e-07Least InformativeInherited
Molecular Function (MF)carbohydrate derivative binding3.121e-130InformativeDirect
Cellular Component (CC)extracellular region part0.00013032.48e-09Moderately InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 4.741e-11 Least Informative Direct
Biological Process (BP) response to stimulus 0.0007664 Least Informative Direct
Biological Process (BP) developmental process 0.01853 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.2688 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.6009 Least Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.0007309 Moderately Informative Direct
Biological Process (BP) system process 0.2281 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.01891 Moderately Informative Inherited
Biological Process (BP) single-organism behavior 2.165e-12 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 1.618e-07 Informative Direct
Biological Process (BP) proteolysis 1.035e-06 Informative Direct
Biological Process (BP) response to wounding 2.344e-05 Informative Direct
Biological Process (BP) regulation of anatomical structure size 3.923e-05 Informative Direct
Biological Process (BP) defense response 0.0002615 Informative Direct
Biological Process (BP) aminoglycan catabolic process 0 Highly Informative Direct
Biological Process (BP) amino sugar metabolic process 0 Highly Informative Direct
Biological Process (BP) respiratory system development 2.321e-06 Highly Informative Direct
Biological Process (BP) learning or memory 0.01063 Highly Informative Inherited
Molecular Function (MF) binding 2.636e-07 Least Informative Direct
Molecular Function (MF) hydrolase activity 3.691e-11 Least Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0 Informative Direct
Molecular Function (MF) hydrolase activity, acting on glycosyl bonds 0.0002404 Informative Direct
Molecular Function (MF) peptidase activity 0.02914 Informative Inherited
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0.001471 Informative Inherited
Molecular Function (MF) endopeptidase activity 5.247e-10 Highly Informative Direct
Molecular Function (MF) deacetylase activity 5.856e-07 Highly Informative Direct
Cellular Component (CC) extracellular region part 2.48e-09 Moderately Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0Moderately InformativeDirect
Enzyme Commission (EC)Chitinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)early embryonic lethal0.01333Moderately InformativeInherited

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0.1712Least InformativeInherited
Fly Anatomy (FA)organ system0.4412Least InformativeInherited
Fly Anatomy (FA)acellular anatomical structure0.01821Moderately InformativeInherited
Fly Anatomy (FA)portion of tissue0.1814Moderately InformativeInherited
Fly Anatomy (FA)embryonic/larval cuticle0.0006909InformativeDirect
Fly Anatomy (FA)tracheal system0.003313InformativeInherited
Fly Anatomy (FA)epithelial tube0.004228InformativeInherited
Fly Anatomy (FA)embryonic/first instar larval cuticle0.0001618Highly InformativeDirect
Fly Anatomy (FA)trachea0.0003224Highly InformativeDirect

Document: FA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Glycosylases0Moderately InformativeDirect
Enzyme Commission (EC)Chitinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCarbohydrate metabolism2.326e-12Moderately InformativeDirect
Biological processPolysaccharide degradation0InformativeDirect
Cellular componentSecreted1.46e-07Moderately InformativeDirect
DomainSignal0Least InformativeDirect
DomainRepeat0.0004744Least InformativeDirect
Molecular functionChitin-binding0Highly InformativeDirect
Post-translational modificationHydrolase0.003949Least InformativeInherited
Post-translational modificationGlycosidase4.216e-14InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationGlycoprotein0.0001427Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR002557 SSF57625 Protein matches
Abstract

The Peritrophin-A domain is found in chitin binding proteins, particularly the peritrophic matrix proteins of insects and animal chitinases [PubMed9651363, PubMed8621536, PubMed9256413]. Copies of the domain are also found in some baculoviruses. It is an extracellular domain that contains six conserved cysteines that probably form three disulphide bridges. Chitin binding has been demonstrated for a protein containing only two of these domains [PubMed9651363].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Fly Anatomy (FA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Invertebrate chitin-binding proteins domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Invertebrate chitin-binding proteins superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Fly Anatomy (FA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]