SUPERFAMILY 1.75 HMM library and genome assignments server


Invertebrate chitin-binding proteins superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Invertebrate chitin-binding proteins [ 57624]
Superfamily:   Invertebrate chitin-binding proteins [ 57625] (2)
Families:   Tachycitin [ 57626]
  Antifungal peptide scarabaecin [ 90179]


Superfamily statistics
Genomes (173) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 8,784 10,293 3
Proteins 3,782 4,843 3


Functional annotation
General category Metabolism
Detailed category Carbohydrate metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Molecular Function (MF)binding0.0039568.351e-07Least InformativeInherited
Molecular Function (MF)carbohydrate derivative binding3.401e-130InformativeDirect
Cellular Component (CC)extracellular region part0.00017065.696e-09Moderately InformativeDirect
Cellular Component (CC)extracellular space5.828e-063.237e-13InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 1.233e-10 Least Informative Direct
Biological Process (BP) response to stimulus 0.001411 Least Informative Inherited
Biological Process (BP) developmental process 0.02529 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.261 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.6013 Least Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 5.657e-06 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.0007462 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.02712 Moderately Informative Inherited
Biological Process (BP) system process 0.2297 Moderately Informative Inherited
Biological Process (BP) single-organism behavior 4.249e-12 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 2.182e-07 Informative Direct
Biological Process (BP) proteolysis 1.433e-06 Informative Direct
Biological Process (BP) response to wounding 3.002e-05 Informative Direct
Biological Process (BP) defense response 0.0003542 Informative Direct
Biological Process (BP) aminoglycan catabolic process 0 Highly Informative Direct
Biological Process (BP) amino sugar metabolic process 0 Highly Informative Direct
Biological Process (BP) respiratory system development 2.142e-06 Highly Informative Direct
Biological Process (BP) learning or memory 0.009935 Highly Informative Inherited
Molecular Function (MF) binding 8.351e-07 Least Informative Direct
Molecular Function (MF) hydrolase activity 7.63e-11 Least Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0 Informative Direct
Molecular Function (MF) hydrolase activity, acting on glycosyl bonds 0.0002396 Informative Direct
Molecular Function (MF) peptidase activity 0.0283 Informative Inherited
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0.001443 Informative Inherited
Molecular Function (MF) endopeptidase activity 7.129e-10 Highly Informative Direct
Molecular Function (MF) deacetylase activity 4.926e-07 Highly Informative Direct
Molecular Function (MF) serine hydrolase activity 8.266e-07 Highly Informative Direct
Cellular Component (CC) extracellular region part 5.696e-09 Moderately Informative Direct
Cellular Component (CC) extracellular space 3.237e-13 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0Moderately InformativeDirect
Enzyme Commission (EC)Chitinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)early embryonic lethal0.01333Moderately InformativeInherited

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0.166Least InformativeInherited
Fly Anatomy (FA)organ system0.4318Least InformativeInherited
Fly Anatomy (FA)acellular anatomical structure0.01618Moderately InformativeInherited
Fly Anatomy (FA)epithelium0.04897Moderately InformativeInherited
Fly Anatomy (FA)embryonic/larval integumentary system0.0006868InformativeDirect
Fly Anatomy (FA)tracheal system0.003133InformativeInherited
Fly Anatomy (FA)epithelial tube0.00389InformativeInherited
Fly Anatomy (FA)embryonic/first instar larval cuticle0.0001517Highly InformativeDirect

Document: FA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Glycosylases0Moderately InformativeDirect
Enzyme Commission (EC)Chitinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCarbohydrate metabolism2.367e-12Moderately InformativeDirect
Biological processPolysaccharide degradation0InformativeDirect
Cellular componentSecreted1.466e-07Moderately InformativeDirect
DomainSignal0Least InformativeDirect
DomainRepeat0.0004713Least InformativeDirect
Molecular functionChitin-binding0Highly InformativeDirect
Post-translational modificationHydrolase0.00397Least InformativeInherited
Post-translational modificationGlycosidase4.195e-14InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationGlycoprotein0.0001372Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR002557 SSF57625 Protein matches
Abstract

The Peritrophin-A domain is found in chitin binding proteins, particularly the peritrophic matrix proteins of insects and animal chitinases [PubMed9651363, PubMed8621536, PubMed9256413]. Copies of the domain are also found in some baculoviruses. It is an extracellular domain that contains six conserved cysteines that probably form three disulphide bridges. Chitin binding has been demonstrated for a protein containing only two of these domains [PubMed9651363].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Fly Anatomy (FA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Invertebrate chitin-binding proteins domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Invertebrate chitin-binding proteins superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Fly Anatomy (FA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]