SUPERFAMILY 1.75 HMM library and genome assignments server


Serine protease inhibitors superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Serine protease inhibitors [ 57566]
Superfamily:   Serine protease inhibitors [ 57567] (2)
Families:   ATI-like [ 57568] (4)
  BSTI [ 57577]


Superfamily statistics
Genomes (132) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 5,167 5,318 6
Proteins 2,022 2,111 6


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details) Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 4.594e-05 Least Informative Direct
Biological Process (BP) developmental process 0.02676 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.9499 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.96 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.2226 Least Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.3383 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.08045 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.1112 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.3537 Moderately Informative Inherited
Biological Process (BP) regulation of programmed cell death 0.06427 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.7849 Moderately Informative Inherited
Biological Process (BP) system process 0.4533 Moderately Informative Inherited
Biological Process (BP) organ development 0.2602 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.02859 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.08023 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.6136 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.2486 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.1592 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.02074 Moderately Informative Inherited
Biological Process (BP) tissue development 0.8259 Moderately Informative Inherited
Biological Process (BP) regulation of body fluid levels 1.343e-12 Informative Direct
Biological Process (BP) response to wounding 3.241e-10 Informative Direct
Biological Process (BP) cell activation 4.364e-10 Informative Direct
Biological Process (BP) biological adhesion 2.936e-08 Informative Direct
Biological Process (BP) regulation of defense response 8.078e-05 Informative Direct
Biological Process (BP) gland development 0.000154 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.0001731 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0.0001823 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.0003235 Informative Direct
Biological Process (BP) regulation of locomotion 0.0005722 Informative Direct
Biological Process (BP) protein complex assembly 0.008314 Informative Inherited
Biological Process (BP) epithelium development 0.006127 Informative Inherited
Biological Process (BP) hemostasis 0 Highly Informative Direct
Biological Process (BP) wound healing 3.746e-15 Highly Informative Direct
Biological Process (BP) coagulation 2.052e-13 Highly Informative Direct
Biological Process (BP) cell adhesion 2.498e-09 Highly Informative Direct
Biological Process (BP) post-translational protein modification 4.014e-08 Highly Informative Direct
Biological Process (BP) regulation of inflammatory response 5.199e-08 Highly Informative Direct
Biological Process (BP) placenta development 1.232e-07 Highly Informative Direct
Biological Process (BP) negative regulation of response to external stimulus 1.553e-06 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 3.196e-06 Highly Informative Direct
Biological Process (BP) protein glycosylation 9.568e-06 Highly Informative Direct
Biological Process (BP) protein homooligomerization 1.297e-05 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 5.616e-05 Highly Informative Direct
Biological Process (BP) epithelial cell development 9.714e-05 Highly Informative Direct
Biological Process (BP) sensory perception 9.811e-05 Highly Informative Direct
Biological Process (BP) positive regulation of programmed cell death 0.0001314 Highly Informative Direct
Molecular Function (MF) binding 0.204 Least Informative Inherited
Molecular Function (MF) structural molecule activity 0.0001612 Moderately Informative Direct
Molecular Function (MF) protein dimerization activity 0.004361 Informative Inherited
Molecular Function (MF) receptor binding 0.07134 Informative Inherited
Molecular Function (MF) enzyme binding 0.06162 Informative Inherited
Molecular Function (MF) protein homodimerization activity 9.85e-06 Highly Informative Direct
Molecular Function (MF) protein complex binding 0.000646 Highly Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0.002226 Moderately Informative Inherited
Cellular Component (CC) plasma membrane part 0.06869 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.4555 Moderately Informative Inherited
Cellular Component (CC) extracellular matrix 0 Informative Direct
Cellular Component (CC) secretory granule 6.179e-06 Informative Direct
Cellular Component (CC) coated vesicle 5.886e-05 Informative Direct
Cellular Component (CC) cell surface 0.0001312 Informative Direct
Cellular Component (CC) Golgi apparatus 0.008956 Informative Inherited
Cellular Component (CC) proteinaceous extracellular matrix 9.497e-08 Highly Informative Direct
Cellular Component (CC) external side of plasma membrane 6.942e-07 Highly Informative Direct
Cellular Component (CC) clathrin-coated vesicle 1.191e-05 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)benign neoplasm0.001698Moderately InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details) Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)pericellular component development variant2.93e-05Moderately InformativeDirect
Worm Phenotype (WP)basement membrane remodeling variant1.202e-05InformativeDirect

Document: WP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell adhesion0InformativeDirect
Biological processHemostasis1.117e-11InformativeDirect
Biological processBlood coagulation1.064e-11Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
DomainSignal0Least InformativeDirect
DomainRepeat1.007e-10Least InformativeDirect
DomainEGF-like domain6.388e-13InformativeDirect
Molecular functionCalcium0.000892Moderately InformativeDirect
Post-translational modificationProtease inhibitor0InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationGlycoprotein4.753e-10Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR002919 SSF57567 Protein matches
Abstract

This domain is found in proteinase inhibitors as well as in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.

This inhibitor domain belongs to MEROPS inhibitor family I8 (clan IA). Proteins containing this domain inhibit peptidases belonging to families S1 , S8 , and M4 [PubMed14705960] and are restricted to the chordata, nematoda, arthropoda and echinodermata. Examples of proteins containing this domain are:

  • chymotrypsin/elastase inhibitor from Ascaris suum (pig roundworm)
  • Acp62F protein from Drosophila melanogaster
  • Bombina trypsin inhibitor from Bombina maxima (large-webbed bell toad)
  • Bombyx subtilisin inhibitor from Bombyx mori (silk moth)
  • von Willebrand factor

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Serine protease inhibitors domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the Serine protease inhibitors superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · UniProtKB KeyWords (KW) · Internal database links ]