SUPERFAMILY 1.75 HMM library and genome assignments server

Serine protease inhibitors superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Serine protease inhibitors [ 57566]
Superfamily:   Serine protease inhibitors [ 57567] (2)
Families:   ATI-like [ 57568] (4)
  BSTI [ 57577]


Superfamily statistics
Genomes (144) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 5,653 6,719 6
Proteins 2,170 2,819 6


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details) Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0.00004399 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.04695 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.4104 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.9919 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) developmental process 0.02307 Least Informative Inherited
Biological Process (BP) immune system process 0.0005941 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.007107 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.1535 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.576 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.3949 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.3589 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.0346 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.6282 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.1617 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.605 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.1932 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.08637 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.2672 Moderately Informative Inherited
Biological Process (BP) tissue development 0.53 Moderately Informative Inherited
Biological Process (BP) organ development 0.2119 Moderately Informative Inherited
Biological Process (BP) reproductive process 0.02688 Moderately Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.00000000000005988 Informative Direct
Biological Process (BP) gland development 0.0000000001119 Informative Direct
Biological Process (BP) biological adhesion 0.00000003623 Informative Direct
Biological Process (BP) regulation of response to wounding 0.0000008315 Informative Direct
Biological Process (BP) hematopoietic or lymphoid organ development 0.00009886 Informative Direct
Biological Process (BP) regulation of defense response 0.0001025 Informative Direct
Biological Process (BP) protein oligomerization 0.0001299 Informative Direct
Biological Process (BP) response to bacterium 0.0001377 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.0003871 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.0005823 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0.0007492 Informative Direct
Biological Process (BP) regulation of locomotion 0.0009189 Informative Direct
Biological Process (BP) neurological system process 0.2567 Informative Inherited
Biological Process (BP) epithelium development 0.001031 Informative Inherited
Biological Process (BP) single organism reproductive process 0.02344 Informative Inherited
Biological Process (BP) reproductive structure development 0.03329 Informative Inherited
Biological Process (BP) hemostasis 0 Highly Informative Direct
Biological Process (BP) wound healing 0 Highly Informative Direct
Biological Process (BP) coagulation 0.00000000000001071 Highly Informative Direct
Biological Process (BP) cell adhesion 0.000000002521 Highly Informative Direct
Biological Process (BP) post-translational protein modification 0.00000003911 Highly Informative Direct
Biological Process (BP) placenta development 0.0000001495 Highly Informative Direct
Biological Process (BP) negative regulation of response to wounding 0.0000008205 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 0.000004362 Highly Informative Direct
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.000007299 Highly Informative Direct
Biological Process (BP) protein homooligomerization 0.00001554 Highly Informative Direct
Biological Process (BP) protein glycosylation 0.0000205 Highly Informative Direct
Biological Process (BP) negative regulation of response to external stimulus 0.00002402 Highly Informative Direct
Biological Process (BP) negative regulation of defense response 0.00002656 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 0.00006456 Highly Informative Direct
Biological Process (BP) sensory perception 0.0001166 Highly Informative Direct
Biological Process (BP) epithelial cell development 0.0002572 Highly Informative Direct
Molecular Function (MF) binding 0.2236 Least Informative Inherited
Molecular Function (MF) structural molecule activity 0.0002267 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.03665 Moderately Informative Inherited
Molecular Function (MF) protein dimerization activity 0.001461 Informative Inherited
Molecular Function (MF) protein complex binding 0.03501 Informative Inherited
Molecular Function (MF) receptor binding 0.07965 Informative Inherited
Molecular Function (MF) enzyme binding 0.08775 Informative Inherited
Molecular Function (MF) protein homodimerization activity 0.000001488 Highly Informative Direct
Molecular Function (MF) cell adhesion molecule binding 0.00004089 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0.0007719 Moderately Informative Direct
Cellular Component (CC) plasma membrane part 0.09935 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.5562 Moderately Informative Inherited
Cellular Component (CC) extracellular matrix 0 Informative Direct
Cellular Component (CC) side of membrane 0.000003829 Informative Direct
Cellular Component (CC) secretory granule 0.0000379 Informative Direct
Cellular Component (CC) cell surface 0.0003006 Informative Direct
Cellular Component (CC) Golgi apparatus 0.01893 Informative Inherited
Cellular Component (CC) proteinaceous extracellular matrix 0.00000001214 Highly Informative Direct
Cellular Component (CC) external side of plasma membrane 0.0000007791 Highly Informative Direct
Cellular Component (CC) coated vesicle 0.000003837 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.1022Least InformativeInherited
Disease Ontology (DO)obstructive lung disease0.0003147Moderately InformativeDirect
Disease Ontology (DO)sensory system disease0.0006621Moderately InformativeDirect
Disease Ontology (DO)benign neoplasm0.001767Moderately InformativeInherited
Disease Ontology (DO)chronic obstructive pulmonary disease0.00002206InformativeDirect
Disease Ontology (DO)cell type benign neoplasm0.0003312InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details) Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details) Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)pericellular component development variant0.0000293Moderately InformativeDirect
Worm Phenotype (WP)basement membrane remodeling variant0.00001202InformativeDirect

Document: WP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell adhesion0InformativeDirect
Biological processHemostasis0.00000000001585InformativeDirect
Biological processBlood coagulation0.00000000001512Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
DomainSignal0Least InformativeDirect
DomainRepeat0.0000000002541Least InformativeDirect
DomainEGF-like domain0.0000000000007784InformativeDirect
Post-translational modificationProtease inhibitor0InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationGlycoprotein0.000000005478Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR002919 SSF57567 Protein matches
Abstract

This domain is found in proteinase inhibitors as well as in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.

This inhibitor domain belongs to MEROPS inhibitor family I8 (clan IA). Proteins containing this domain inhibit peptidases belonging to families S1 , S8 , and M4 [PubMed14705960] and are restricted to the chordata, nematoda, arthropoda and echinodermata. Examples of proteins containing this domain are:

  • chymotrypsin/elastase inhibitor from Ascaris suum (pig roundworm)
  • Acp62F protein from Drosophila melanogaster
  • Bombina trypsin inhibitor from Bombina maxima (large-webbed bell toad)
  • Bombyx subtilisin inhibitor from Bombyx mori (silk moth)
  • von Willebrand factor

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Serine protease inhibitors domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the Serine protease inhibitors superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · UniProtKB KeyWords (KW) · Internal database links ]