SUPERFAMILY 1.75 HMM library and genome assignments server


Cystine-knot cytokines superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Cystine-knot cytokines [ 57500]
Superfamily:   Cystine-knot cytokines [ 57501] (7)
Families:   Platelet-derived growth factor-like [ 57502] (3)
  Transforming growth factor (TGF)-beta [ 57507] (7)
  Noggin [ 82904]
  Neurotrophin [ 57520] (4)
  Gonadodropin/Follitropin [ 57528] (3)
  Interleukin 17F, IL-17F [ 69955]
  Coagulogen [ 57531]


Superfamily statistics
Genomes (139) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 6,152 14,377 40
Proteins 6,123 14,339 40


Functional annotation
General category Processes_IC
Detailed category Cell cycle, Apoptosis

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus1.528e-110Least InformativeDirect
Biological Process (BP)developmental process2.669e-100Least InformativeDirect
Biological Process (BP)multicellular organismal process8.618e-090Least InformativeDirect
Biological Process (BP)single-organism cellular process2.592e-051.944e-15Least InformativeDirect
Biological Process (BP)regulation of cellular process0.14172.669e-05Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.9150.0004872Least InformativeInherited
Biological Process (BP)localization0.62732.97e-09Least InformativeInherited
Biological Process (BP)protein metabolic process0.084393.981e-09Least InformativeInherited
Biological Process (BP)reproduction2.436e-080Moderately InformativeDirect
Biological Process (BP)response to organic substance5.024e-080.0003601Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process3.952e-060Moderately InformativeDirect
Biological Process (BP)cell differentiation0.0002050Moderately InformativeDirect
Biological Process (BP)immune system process0.00052730Moderately InformativeDirect
Biological Process (BP)regulation of developmental process0.00053750Moderately InformativeDirect
Biological Process (BP)regulation of localization10Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.3350.0007928Moderately InformativeInherited
Biological Process (BP)tissue development0.07129.286e-14Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.14262.755e-13Moderately InformativeInherited
Biological Process (BP)organ development0.010844.991e-09Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.049840Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.099730Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.047530.8092Moderately InformativeInherited
Biological Process (BP)signal transduction0.1270Moderately InformativeInherited
Biological Process (BP)system process0.36980.6875Moderately InformativeInherited
Biological Process (BP)homeostatic process0.63221Moderately InformativeInherited
Biological Process (BP)gene expression0.011831Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process13.04e-13Moderately InformativeInherited
Biological Process (BP)regulation of biosynthetic process0.021471.758e-07Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.30471Moderately InformativeInherited
Biological Process (BP)nervous system development0.73070.9627Moderately InformativeInherited
Biological Process (BP)regulation of transcription from RNA polymerase II promoter3.787e-094.574e-13InformativeDirect
Biological Process (BP)generation of neurons5.867e-060InformativeDirect
Biological Process (BP)blood circulation1.043e-053.135e-14InformativeDirect
Biological Process (BP)response to wounding2.21e-053.77e-15InformativeDirect
Biological Process (BP)single organism reproductive process0.00012944.232e-09InformativeDirect
Biological Process (BP)gland development0.0001368.841e-08InformativeDirect
Biological Process (BP)positive regulation of developmental process0.00014340InformativeDirect
Biological Process (BP)regulation of hormone levels0.00014610.0001178InformativeDirect
Biological Process (BP)tube development0.00015150InformativeDirect
Biological Process (BP)growth0.00022174.644e-09InformativeDirect
Biological Process (BP)positive regulation of gene expression0.0003320InformativeDirect
Biological Process (BP)localization of cell0.00038080InformativeDirect
Biological Process (BP)locomotion0.00059180InformativeDirect
Biological Process (BP)enzyme linked receptor protein signaling pathway0.0007690InformativeDirect
Biological Process (BP)positive regulation of cell proliferation0.00089370InformativeDirect
Biological Process (BP)regulation of anatomical structure morphogenesis0.0060537.963e-13InformativeInherited
Biological Process (BP)regulation of defense response0.0043111InformativeInherited
Biological Process (BP)regulation of response to external stimulus0.073841.15e-06InformativeInherited
Biological Process (BP)regulation of cytokine production0.2420.05202InformativeInherited
Biological Process (BP)positive regulation of multicellular organismal process0.0033640InformativeInherited
Biological Process (BP)epithelium development0.62951InformativeInherited
Biological Process (BP)positive regulation of nitrogen compound metabolic process0.0029450InformativeInherited
Biological Process (BP)cardiovascular system development0.037330InformativeInherited
Biological Process (BP)muscle tissue development0.018540.2401InformativeInherited
Biological Process (BP)muscle structure development0.030510.04865InformativeInherited
Biological Process (BP)positive regulation of macromolecule biosynthetic process0.0019817.377e-15InformativeInherited
Biological Process (BP)positive regulation of cellular biosynthetic process0.0031991.614e-10InformativeInherited
Biological Process (BP)multicellular organismal reproductive process0.14155.33e-05InformativeInherited
Biological Process (BP)sensory organ development0.073690.001283InformativeInherited
Biological Process (BP)organ morphogenesis0.14952.168e-10InformativeInherited
Biological Process (BP)embryonic organ development0.014231.287e-07InformativeInherited
Biological Process (BP)regulation of cellular component movement0.15950InformativeInherited
Biological Process (BP)regulation of locomotion0.1740InformativeInherited
Biological Process (BP)hematopoietic or lymphoid organ development0.0073420InformativeInherited
Biological Process (BP)cellular component movement0.088520InformativeInherited
Biological Process (BP)regulation of body fluid levels0.0032070.0001864InformativeInherited
Biological Process (BP)regulation of cell development0.046610.2532InformativeInherited
Biological Process (BP)regulation of nervous system development0.059261InformativeInherited
Biological Process (BP)tissue morphogenesis0.03282.127e-09InformativeInherited
Biological Process (BP)reproductive system development6.482e-050.04712InformativeInherited
Biological Process (BP)developmental process involved in reproduction0.0044080.05414InformativeInherited
Biological Process (BP)anatomical structure formation involved in morphogenesis0.024961.171e-09InformativeInherited
Biological Process (BP)gonad development7.864e-091.339e-12Highly InformativeDirect
Biological Process (BP)chemical homeostasis within a tissue9.505e-091.944e-15Highly InformativeDirect
Biological Process (BP)ovulation cycle process1.145e-080Highly InformativeDirect
Biological Process (BP)protein processing1.761e-080.0003107Highly InformativeDirect
Biological Process (BP)vascular process in circulatory system3.249e-080.0005979Highly InformativeDirect
Biological Process (BP)branching morphogenesis of an epithelial tube4.318e-080.0006679Highly InformativeDirect
Biological Process (BP)mammary gland alveolus development8.453e-078.756e-08Highly InformativeDirect
Biological Process (BP)cardiocyte differentiation3.974e-063.77e-15Highly InformativeDirect
Biological Process (BP)regulation of transmembrane receptor protein serine/threonine kinase signaling pathway1.37e-050Highly InformativeDirect
Biological Process (BP)lactation6.757e-054.566e-05Highly InformativeDirect
Biological Process (BP)angiogenesis7.307e-050Highly InformativeDirect
Biological Process (BP)renal system development0.0001084.457e-13Highly InformativeDirect
Biological Process (BP)positive regulation of cell migration0.00015295.479e-13Highly InformativeDirect
Biological Process (BP)heart morphogenesis0.0001895.92e-11Highly InformativeDirect
Biological Process (BP)respiratory tube development0.00025152.399e-10Highly InformativeDirect
Biological Process (BP)positive regulation of transcription, DNA-dependent0.000280Highly InformativeDirect
Biological Process (BP)pattern specification process0.00029041.151e-11Highly InformativeDirect
Biological Process (BP)regulation of cell adhesion0.00035390Highly InformativeDirect
Biological Process (BP)artery morphogenesis0.00081210.0007273Highly InformativeDirect
Biological Process (BP)positive regulation of cytokine production0.10271Highly InformativeInherited
Biological Process (BP)respiratory system development0.0011455.988e-05Highly InformativeInherited
Biological Process (BP)erythrocyte differentiation0.14950.6484Highly InformativeInherited
Biological Process (BP)cardiac muscle tissue development1.192e-070.03172Highly InformativeInherited
Biological Process (BP)muscle fiber development1.622e-070.1758Highly InformativeInherited
Biological Process (BP)transmembrane receptor protein tyrosine kinase signaling pathway0.17171Highly InformativeInherited
Biological Process (BP)photoreceptor cell differentiation9.312e-080.112Highly InformativeInherited
Biological Process (BP)eye morphogenesis0.00041451Highly InformativeInherited
Biological Process (BP)post-embryonic organ development0.0027081Highly InformativeInherited
Biological Process (BP)post-embryonic development0.084261Highly InformativeInherited
Biological Process (BP)regulation of neural precursor cell proliferation0.00048250.107Highly InformativeInherited
Biological Process (BP)positive regulation of neurogenesis0.037940.2464Highly InformativeInherited
Biological Process (BP)positive regulation of epithelial cell proliferation0.0020030Highly InformativeInherited
Biological Process (BP)development of primary female sexual characteristics0.35160.0001109Highly InformativeInherited
Molecular Function (MF)binding5.163e-070Least InformativeDirect
Molecular Function (MF)anion binding0.020154.09e-06Moderately InformativeInherited
Molecular Function (MF)receptor binding00InformativeDirect
Molecular Function (MF)sulfur compound binding3.29e-050InformativeDirect
Molecular Function (MF)carbohydrate derivative binding4.606e-050InformativeDirect
Molecular Function (MF)heparin binding9.486e-080Highly InformativeDirect
Molecular Function (MF)growth factor receptor binding0.15431.902e-06Highly InformativeInherited
Molecular Function (MF)cytokine receptor binding0.81945.96e-08Highly InformativeInherited
Cellular Component (CC)extracellular region part00Moderately InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 1.944e-15 Least Informative Direct
Biological Process (BP) protein metabolic process 3.981e-09 Least Informative Direct
Biological Process (BP) regulation of cellular process 2.669e-05 Least Informative Direct
Biological Process (BP) localization 2.97e-09 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.0004872 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 4.932e-07 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.1939 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.005826 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) reproduction 0 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.0003601 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0 Moderately Informative Direct
Biological Process (BP) cell differentiation 0 Moderately Informative Direct
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0 Moderately Informative Direct
Biological Process (BP) organ development 4.991e-09 Moderately Informative Direct
Biological Process (BP) regulation of biosynthetic process 1.758e-07 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0 Moderately Informative Direct
Biological Process (BP) tissue development 9.286e-14 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 4.848e-08 Moderately Informative Direct
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 2.755e-13 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.0007928 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 0 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 8.333e-14 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 3.04e-13 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 2.683e-12 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 6.608e-10 Moderately Informative Direct
Biological Process (BP) organic substance transport 0.0001111 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0.0001145 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.8092 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.1808 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.05429 Moderately Informative Inherited
Biological Process (BP) regulation of programmed cell death 0.9052 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.07077 Moderately Informative Inherited
Biological Process (BP) system process 0.6875 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.001624 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.01738 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.08773 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.9627 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.1208 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.085 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.3062 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.3513 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.8099 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.4638 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.344 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.001545 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.5415 Moderately Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 4.574e-13 Informative Direct
Biological Process (BP) generation of neurons 0 Informative Direct
Biological Process (BP) blood circulation 3.135e-14 Informative Direct
Biological Process (BP) response to wounding 3.77e-15 Informative Direct
Biological Process (BP) single organism reproductive process 4.232e-09 Informative Direct
Biological Process (BP) gland development 8.841e-08 Informative Direct
Biological Process (BP) positive regulation of developmental process 0 Informative Direct
Biological Process (BP) regulation of hormone levels 0.0001178 Informative Direct
Biological Process (BP) tube development 0 Informative Direct
Biological Process (BP) growth 4.644e-09 Informative Direct
Biological Process (BP) positive regulation of gene expression 0 Informative Direct
Biological Process (BP) localization of cell 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0 Informative Direct
Biological Process (BP) positive regulation of cell proliferation 0 Informative Direct
Biological Process (BP) negative regulation of cell death 5.194e-11 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 7.377e-15 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 1.614e-10 Informative Direct
Biological Process (BP) regulation of body fluid levels 0.0001864 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 7.963e-13 Informative Direct
Biological Process (BP) hematopoietic or lymphoid organ development 0 Informative Direct
Biological Process (BP) embryonic organ development 1.287e-07 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 1.171e-09 Informative Direct
Biological Process (BP) tissue morphogenesis 2.127e-09 Informative Direct
Biological Process (BP) cardiovascular system development 0 Informative Direct
Biological Process (BP) regulation of response to external stimulus 1.15e-06 Informative Direct
Biological Process (BP) cellular component movement 0 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 3.474e-10 Informative Direct
Biological Process (BP) negative regulation of developmental process 1.295e-09 Informative Direct
Biological Process (BP) multicellular organismal reproductive process 5.33e-05 Informative Direct
Biological Process (BP) organ morphogenesis 2.168e-10 Informative Direct
Biological Process (BP) regulation of cellular component movement 0 Informative Direct
Biological Process (BP) regulation of locomotion 0 Informative Direct
Biological Process (BP) regulation of growth 3.77e-15 Informative Direct
Biological Process (BP) positive regulation of signal transduction 0 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 0 Informative Direct
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) positive regulation of protein modification process 0 Informative Direct
Biological Process (BP) regulation of establishment of protein localization 0 Informative Direct
Biological Process (BP) regulation of protein phosphorylation 7.721e-13 Informative Direct
Biological Process (BP) positive regulation of transport 2.23e-12 Informative Direct
Biological Process (BP) protein localization to organelle 3.939e-12 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 7.759e-12 Informative Direct
Biological Process (BP) apoptotic process 9.501e-11 Informative Direct
Biological Process (BP) secretion by cell 5.046e-09 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 7.242e-07 Informative Direct
Biological Process (BP) response to nutrient levels 1.388e-05 Informative Direct
Biological Process (BP) cell projection organization 1.517e-05 Informative Direct
Biological Process (BP) glycosyl compound biosynthetic process 1.69e-05 Informative Direct
Biological Process (BP) ribose phosphate biosynthetic process 1.698e-05 Informative Direct
Biological Process (BP) cellular component morphogenesis 1.946e-05 Informative Direct
Biological Process (BP) purine-containing compound biosynthetic process 3.171e-05 Informative Direct
Biological Process (BP) regulation of secretion 0.0001214 Informative Direct
Biological Process (BP) lipid localization 0.0001442 Informative Direct
Biological Process (BP) cytoplasmic transport 0.0002089 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 0.0003074 Informative Direct
Biological Process (BP) cellular process involved in reproduction 0.0004946 Informative Direct
Biological Process (BP) regulation of apoptotic signaling pathway 0.01633 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.1358 Informative Inherited
Biological Process (BP) regulation of defense response 1 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.1084 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.02733 Informative Inherited
Biological Process (BP) response to lipid 0.003988 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.002896 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.3121 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.001675 Informative Inherited
Biological Process (BP) sensory organ development 0.001283 Informative Inherited
Biological Process (BP) muscle tissue development 0.2401 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.8678 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) muscle structure development 0.04865 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.02245 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.05293 Informative Inherited
Biological Process (BP) negative regulation of transport 0.003775 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.05414 Informative Inherited
Biological Process (BP) organic hydroxy compound biosynthetic process 0.08565 Informative Inherited
Biological Process (BP) purine ribonucleoside metabolic process 0.1044 Informative Inherited
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 0.02007 Informative Inherited
Biological Process (BP) protein complex assembly 0.03698 Informative Inherited
Biological Process (BP) regulation of kinase activity 1 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 1 Informative Inherited
Biological Process (BP) regulation of intracellular transport 1 Informative Inherited
Biological Process (BP) regulation of ion transport 1 Informative Inherited
Biological Process (BP) regulation of system process 0.001936 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 0.1353 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.01186 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.03742 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.1882 Informative Inherited
Biological Process (BP) response to other organism 0.09777 Informative Inherited
Biological Process (BP) muscle system process 0.4744 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 1 Informative Inherited
Biological Process (BP) regulation of cell development 0.2532 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.9332 Informative Inherited
Biological Process (BP) nucleotide biosynthetic process 0.001205 Informative Inherited
Biological Process (BP) nucleoside triphosphate metabolic process 0.0598 Informative Inherited
Biological Process (BP) nucleoside monophosphate metabolic process 0.01298 Informative Inherited
Biological Process (BP) purine ribonucleotide metabolic process 0.142 Informative Inherited
Biological Process (BP) single-organism behavior 0.06043 Informative Inherited
Biological Process (BP) multi-multicellular organism process 0.719 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 1 Informative Inherited
Biological Process (BP) regulation of cell cycle process 1 Informative Inherited
Biological Process (BP) cell cycle process 0.1679 Informative Inherited
Biological Process (BP) protein transport 0.6169 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.05202 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.8946 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) reproductive system development 0.04712 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.9632 Informative Inherited
Biological Process (BP) gonad development 1.339e-12 Highly Informative Direct
Biological Process (BP) chemical homeostasis within a tissue 1.944e-15 Highly Informative Direct
Biological Process (BP) ovulation cycle process 0 Highly Informative Direct
Biological Process (BP) protein processing 0.0003107 Highly Informative Direct
Biological Process (BP) vascular process in circulatory system 0.0005979 Highly Informative Direct
Biological Process (BP) branching morphogenesis of an epithelial tube 0.0006679 Highly Informative Direct
Biological Process (BP) mammary gland alveolus development 8.756e-08 Highly Informative Direct
Biological Process (BP) cardiocyte differentiation 3.77e-15 Highly Informative Direct
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0 Highly Informative Direct
Biological Process (BP) lactation 4.566e-05 Highly Informative Direct
Biological Process (BP) angiogenesis 0 Highly Informative Direct
Biological Process (BP) renal system development 4.457e-13 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 5.479e-13 Highly Informative Direct
Biological Process (BP) heart morphogenesis 5.92e-11 Highly Informative Direct
Biological Process (BP) respiratory tube development 2.399e-10 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-dependent 0 Highly Informative Direct
Biological Process (BP) pattern specification process 1.151e-11 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0 Highly Informative Direct
Biological Process (BP) artery morphogenesis 0.0007273 Highly Informative Direct
Biological Process (BP) respiratory system development 5.988e-05 Highly Informative Direct
Biological Process (BP) positive regulation of epithelial cell proliferation 0 Highly Informative Direct
Biological Process (BP) mesenchyme development 0 Highly Informative Direct
Biological Process (BP) regulation of angiogenesis 0.0002128 Highly Informative Direct
Biological Process (BP) developmental maturation 9.227e-07 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 6.351e-09 Highly Informative Direct
Biological Process (BP) regulation of organ morphogenesis 6.255e-14 Highly Informative Direct
Biological Process (BP) development of primary female sexual characteristics 0.0001109 Highly Informative Direct
Biological Process (BP) protein phosphorylation 0 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0 Highly Informative Direct
Biological Process (BP) protein localization to nucleus 0 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 0 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0 Highly Informative Direct
Biological Process (BP) ossification 0 Highly Informative Direct
Biological Process (BP) response to hypoxia 0 Highly Informative Direct
Biological Process (BP) skeletal system development 0 Highly Informative Direct
Biological Process (BP) negative regulation of cell cycle 0 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 0 Highly Informative Direct
Biological Process (BP) hair follicle development 0 Highly Informative Direct
Biological Process (BP) hormone transport 2.125e-14 Highly Informative Direct
Biological Process (BP) chemotaxis 6.409e-14 Highly Informative Direct
Biological Process (BP) protein targeting to nucleus 1.336e-13 Highly Informative Direct
Biological Process (BP) negative regulation of cell growth 1.73e-12 Highly Informative Direct
Biological Process (BP) regulation of behavior 7.833e-12 Highly Informative Direct
Biological Process (BP) regulation of synaptic transmission 7.876e-12 Highly Informative Direct
Biological Process (BP) nuclear import 2.827e-11 Highly Informative Direct
Biological Process (BP) regulation of MAP kinase activity 3.104e-11 Highly Informative Direct
Biological Process (BP) response to glucocorticoid stimulus 1.599e-10 Highly Informative Direct
Biological Process (BP) stem cell development 2.251e-10 Highly Informative Direct
Biological Process (BP) regulation of hormone secretion 4.727e-10 Highly Informative Direct
Biological Process (BP) aminoglycan catabolic process 5.557e-10 Highly Informative Direct
Biological Process (BP) protein import 2.282e-09 Highly Informative Direct
Biological Process (BP) positive regulation of response to external stimulus 3.776e-09 Highly Informative Direct
Biological Process (BP) mitotic cell cycle phase transition 4.9e-09 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate biosynthetic process 9.651e-09 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 1.202e-08 Highly Informative Direct
Biological Process (BP) regulation of production of molecular mediator of immune response 5.491e-08 Highly Informative Direct
Biological Process (BP) glycosaminoglycan metabolic process 5.964e-08 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 2.005e-07 Highly Informative Direct
Biological Process (BP) negative regulation of cell activation 2.775e-07 Highly Informative Direct
Biological Process (BP) negative regulation of lipid biosynthetic process 4.133e-07 Highly Informative Direct
Biological Process (BP) cell cycle phase 1.361e-06 Highly Informative Direct
Biological Process (BP) cell junction organization 1.549e-06 Highly Informative Direct
Biological Process (BP) purine ribonucleotide biosynthetic process 1.626e-06 Highly Informative Direct
Biological Process (BP) regulation of wound healing 2.319e-06 Highly Informative Direct
Biological Process (BP) regulation of reproductive process 6.949e-06 Highly Informative Direct
Biological Process (BP) positive regulation of protein secretion 7.155e-06 Highly Informative Direct
Biological Process (BP) female pregnancy 7.504e-06 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 9.337e-06 Highly Informative Direct
Biological Process (BP) positive regulation of MAPK cascade 1.247e-05 Highly Informative Direct
Biological Process (BP) regulation of cytokine biosynthetic process 1.369e-05 Highly Informative Direct
Biological Process (BP) negative regulation of mitotic cell cycle phase transition 3.687e-05 Highly Informative Direct
Biological Process (BP) extrinsic apoptotic signaling pathway 4.729e-05 Highly Informative Direct
Biological Process (BP) cell fate commitment 4.936e-05 Highly Informative Direct
Biological Process (BP) connective tissue development 5.013e-05 Highly Informative Direct
Biological Process (BP) regulation of mitosis 7.469e-05 Highly Informative Direct
Biological Process (BP) regulation of protein complex assembly 0.0001059 Highly Informative Direct
Biological Process (BP) nuclear export 0.0001654 Highly Informative Direct
Biological Process (BP) endocrine system development 0.0002085 Highly Informative Direct
Biological Process (BP) learning or memory 0.0003005 Highly Informative Direct
Biological Process (BP) regulation of nucleocytoplasmic transport 0.0003168 Highly Informative Direct
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.000354 Highly Informative Direct
Biological Process (BP) regulation of mononuclear cell proliferation 0.0004135 Highly Informative Direct
Biological Process (BP) negative regulation of neuron death 0.0006453 Highly Informative Direct
Biological Process (BP) exocytosis 0.0006658 Highly Informative Direct
Biological Process (BP) positive regulation of lipid metabolic process 0.0007843 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0.0008251 Highly Informative Direct
Biological Process (BP) cellular response to starvation 0.0008549 Highly Informative Direct
Biological Process (BP) response to drug 0.000868 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 0.0008981 Highly Informative Direct
Biological Process (BP) positive regulation of apoptotic signaling pathway 0.005591 Highly Informative Inherited
Biological Process (BP) regulation of binding 0.01981 Highly Informative Inherited
Biological Process (BP) positive regulation of peptidyl-tyrosine phosphorylation 0.002316 Highly Informative Inherited
Biological Process (BP) regulation of hemostasis 0.01359 Highly Informative Inherited
Biological Process (BP) positive regulation of ion transport 1 Highly Informative Inherited
Biological Process (BP) regulation of calcium ion transport 0.05492 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.6582 Highly Informative Inherited
Biological Process (BP) cellular response to steroid hormone stimulus 0.001946 Highly Informative Inherited
Biological Process (BP) response to alcohol 0.07843 Highly Informative Inherited
Biological Process (BP) response to lipopolysaccharide 0.01194 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic process 0.03269 Highly Informative Inherited
Biological Process (BP) regulation of protein localization to nucleus 0.08095 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.1818 Highly Informative Inherited
Biological Process (BP) erythrocyte differentiation 0.6484 Highly Informative Inherited
Biological Process (BP) regulation of striated muscle tissue development 0.5418 Highly Informative Inherited
Biological Process (BP) regulation of protein kinase B signaling cascade 0.004839 Highly Informative Inherited
Biological Process (BP) regulation of amine transport 0.3209 Highly Informative Inherited
Biological Process (BP) cardiac muscle tissue development 0.03172 Highly Informative Inherited
Biological Process (BP) muscle fiber development 0.1758 Highly Informative Inherited
Biological Process (BP) negative regulation of secretion 0.05783 Highly Informative Inherited
Biological Process (BP) regulation of peptide transport 0.1599 Highly Informative Inherited
Biological Process (BP) regulation of myeloid cell differentiation 0.02564 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 0.9131 Highly Informative Inherited
Biological Process (BP) hormone-mediated signaling pathway 0.7719 Highly Informative Inherited
Biological Process (BP) photoreceptor cell differentiation 0.112 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 1 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.003082 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 1 Highly Informative Inherited
Biological Process (BP) signal release 0.1652 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.3316 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.7593 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.8819 Highly Informative Inherited
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 0.001485 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 1 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 1 Highly Informative Inherited
Biological Process (BP) post-embryonic development 1 Highly Informative Inherited
Biological Process (BP) wound healing 0.05177 Highly Informative Inherited
Biological Process (BP) coagulation 0.1189 Highly Informative Inherited
Biological Process (BP) hemostasis 1 Highly Informative Inherited
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.003807 Highly Informative Inherited
Biological Process (BP) modification of morphology or physiology of other organism 0.0138 Highly Informative Inherited
Biological Process (BP) multi-organism cellular process 0.01295 Highly Informative Inherited
Biological Process (BP) cell division 0.7388 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.2514 Highly Informative Inherited
Biological Process (BP) regulation of coagulation 0.02009 Highly Informative Inherited
Biological Process (BP) axon development 0.3294 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in neuron differentiation 1 Highly Informative Inherited
Biological Process (BP) cell projection morphogenesis 1 Highly Informative Inherited
Biological Process (BP) ATP metabolic process 0.005081 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.4176 Highly Informative Inherited
Biological Process (BP) regulation of blood pressure 0.1736 Highly Informative Inherited
Biological Process (BP) regulation of endocytosis 0.003362 Highly Informative Inherited
Biological Process (BP) regulation of neural precursor cell proliferation 0.107 Highly Informative Inherited
Biological Process (BP) positive regulation of neurogenesis 0.2464 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) anion binding 4.09e-06 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0.0007575 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) receptor binding 0 Informative Direct
Molecular Function (MF) sulfur compound binding 0 Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0 Informative Direct
Molecular Function (MF) protein dimerization activity 1.107e-12 Informative Direct
Molecular Function (MF) enzyme activator activity 1.038e-09 Informative Direct
Molecular Function (MF) amide binding 0.04387 Informative Inherited
Molecular Function (MF) molecular transducer activity 0.9636 Informative Inherited
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1 Informative Inherited
Molecular Function (MF) heparin binding 0 Highly Informative Direct
Molecular Function (MF) growth factor receptor binding 1.902e-06 Highly Informative Direct
Molecular Function (MF) cytokine receptor binding 5.96e-08 Highly Informative Direct
Molecular Function (MF) phosphatase regulator activity 1.539e-12 Highly Informative Direct
Molecular Function (MF) cytokine activity 1.917e-08 Highly Informative Direct
Molecular Function (MF) protein homodimerization activity 1.714e-06 Highly Informative Direct
Molecular Function (MF) peptide binding 0.0001624 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0.9489 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) vesicle 6.169e-15 Moderately Informative Direct
Cellular Component (CC) cell projection 0.000248 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 0.447 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) extracellular space 0 Informative Direct
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) extracellular matrix 1.404e-13 Informative Direct
Cellular Component (CC) secretory granule 6.181e-12 Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 2.892e-11 Highly Informative Direct
Cellular Component (CC) cell body 0.001967 Highly Informative Inherited

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.06886Least InformativeInherited
Disease Ontology (DO)immune system disease0.5407Least InformativeInherited
Disease Ontology (DO)benign neoplasm1.607e-07Moderately InformativeDirect
Disease Ontology (DO)lung disease0.0001583Moderately InformativeDirect
Disease Ontology (DO)musculoskeletal system cancer0.01368Moderately InformativeInherited
Disease Ontology (DO)skin disease0.0694Moderately InformativeInherited
Disease Ontology (DO)endocrine system disease0.1079Moderately InformativeInherited
Disease Ontology (DO)bone disease0.2308Moderately InformativeInherited
Disease Ontology (DO)hematologic cancer0.3838Moderately InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.5759Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.7851Moderately InformativeInherited
Disease Ontology (DO)prostate cancer0.0003434InformativeDirect
Disease Ontology (DO)arthropathy0.003353InformativeInherited
Disease Ontology (DO)myeloma0.01583InformativeInherited
Disease Ontology (DO)asthma0.1101InformativeInherited
Disease Ontology (DO)organ system benign neoplasm0.2148InformativeInherited
Disease Ontology (DO)connective tissue cancer0.897InformativeInherited
Disease Ontology (DO)aggressive systemic mastocytosis0.0006529Highly InformativeDirect
Disease Ontology (DO)colonic disease0.006667Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Multifactorial inheritance7.57e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.03947Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of head and neck0.1095Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hand0.007298Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digit0.04239Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.9264Moderately InformativeInherited
Phenotypic Abnormality (PA)Aplasia/hypoplasia involving bones of the lower limbs0.03477InformativeInherited
Phenotypic Abnormality (PA)Abnormal facial shape0.2059InformativeInherited
Phenotypic Abnormality (PA)Abnormality of toe0.5257InformativeInherited
Phenotypic Abnormality (PA)Abnormality of phalanx of finger0.9149InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the middle phalanges of the hand4.086e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Facial asymmetry0.0001809Highly InformativeDirect
Phenotypic Abnormality (PA)Broad toe0.001507Highly InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia of toe0.003641Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the phalanges of the toes0.008431Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hallux0.01706Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the 5th finger0.2292Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)