SUPERFAMILY 1.75 HMM library and genome assignments server

Cystine-knot cytokines superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Cystine-knot cytokines [ 57500]
Superfamily:   Cystine-knot cytokines [ 57501] (7)
Families:   Platelet-derived growth factor-like [ 57502] (3)
  Transforming growth factor (TGF)-beta [ 57507] (7)
  Noggin [ 82904]
  Neurotrophin [ 57520] (4)
  Gonadodropin/Follitropin [ 57528] (3)
  Interleukin 17F, IL-17F [ 69955]
  Coagulogen [ 57531]


Superfamily statistics
Genomes (139) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 6,152 14,377 40
Proteins 6,123 14,339 40


Functional annotation
General category Processes_IC
Detailed category Cell cycle, Apoptosis

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus0.0000000000210Least InformativeDirect
Biological Process (BP)developmental process0.00000000030860Least InformativeDirect
Biological Process (BP)multicellular organismal process0.0000000051920Least InformativeDirect
Biological Process (BP)positive regulation of biological process0.088910Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.40490.0001142Least InformativeInherited
Biological Process (BP)regulation of cellular process0.20610.00006891Least InformativeInherited
Biological Process (BP)single-organism cellular process0.37390.0003929Least InformativeInherited
Biological Process (BP)protein metabolic process0.10820.00000001886Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.45121Least InformativeInherited
Biological Process (BP)localization0.6760.00000002883Least InformativeInherited
Biological Process (BP)reproductive process0.0000000030530Moderately InformativeDirect
Biological Process (BP)response to organic substance0.00000010820.0003172Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process0.0000025350Moderately InformativeDirect
Biological Process (BP)cell differentiation0.00030610Moderately InformativeDirect
Biological Process (BP)immune system process0.00052320Moderately InformativeDirect
Biological Process (BP)regulation of developmental process0.00079790Moderately InformativeDirect
Biological Process (BP)regulation of macromolecule biosynthetic process0.086050.0001008Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus10.000000000000005526Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.33830.000403Moderately InformativeInherited
Biological Process (BP)tissue development0.056140.000000000000003707Moderately InformativeInherited
Biological Process (BP)organ development0.0024410.00000000005336Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.38710.0479Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.14390.000000000001358Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.017640Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.16360.7113Moderately InformativeInherited
Biological Process (BP)regulation of gene expression11Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.78560Moderately InformativeInherited
Biological Process (BP)regulation of localization10Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.064620Moderately InformativeInherited
Biological Process (BP)gene expression0.017541Moderately InformativeInherited
Biological Process (BP)signal transduction0.1030Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process10.000000000005128Moderately InformativeInherited
Biological Process (BP)defense response0.27610.874Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.24440.007942Moderately InformativeInherited
Biological Process (BP)nervous system development0.76371Moderately InformativeInherited
Biological Process (BP)regulation of phosphorus metabolic process0.27690Moderately InformativeInherited
Biological Process (BP)regulation of transcription from RNA polymerase II promoter0.0000000004010.000000000002338InformativeDirect
Biological Process (BP)single organism reproductive process0.000000040460.0000000000004517InformativeDirect
Biological Process (BP)generation of neurons0.0000079680InformativeDirect
Biological Process (BP)regulation of protein phosphorylation0.000012610InformativeDirect
Biological Process (BP)blood circulation0.000013370.00000000000005029InformativeDirect
Biological Process (BP)positive regulation of multicellular organismal process0.000022960InformativeDirect
Biological Process (BP)regulation of hormone levels0.00013370.0001377InformativeDirect
Biological Process (BP)cell proliferation0.00018320.0000000007652InformativeDirect
Biological Process (BP)growth0.00025640.00000001034InformativeDirect
Biological Process (BP)positive regulation of developmental process0.00029870InformativeDirect
Biological Process (BP)localization of cell0.00047130InformativeDirect
Biological Process (BP)gland development0.00047130.000001287InformativeDirect
Biological Process (BP)tube development0.00049640InformativeDirect
Biological Process (BP)regulation of cell proliferation0.00056020InformativeDirect
Biological Process (BP)locomotion0.00060720InformativeDirect
Biological Process (BP)enzyme linked receptor protein signaling pathway0.00072870InformativeDirect
Biological Process (BP)regulation of response to wounding0.00086850.0005474InformativeDirect
Biological Process (BP)regulation of cellular component movement0.16510InformativeInherited
Biological Process (BP)regulation of cell development0.045480.1124InformativeInherited
Biological Process (BP)positive regulation of cellular biosynthetic process0.012140.000000000005001InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.005450.000000000000544InformativeInherited
Biological Process (BP)regulation of defense response0.0053671InformativeInherited
Biological Process (BP)regulation of cytokine production0.28210.08397InformativeInherited
Biological Process (BP)muscle structure development0.022520.0183InformativeInherited
Biological Process (BP)anatomical structure homeostasis0.00001190.001627InformativeInherited
Biological Process (BP)multicellular organismal homeostasis0.0013280.08802InformativeInherited
Biological Process (BP)tissue morphogenesis0.022360.0000000005447InformativeInherited
Biological Process (BP)epithelium development0.15640.3021InformativeInherited
Biological Process (BP)cardiovascular system development0.038270InformativeInherited
Biological Process (BP)positive regulation of RNA metabolic process0.0026190.00000000000003576InformativeInherited
Biological Process (BP)positive regulation of macromolecule biosynthetic process0.013330.0000000000001712InformativeInherited
Biological Process (BP)positive regulation of gene expression0.010380.0000000000001193InformativeInherited
Biological Process (BP)sensory organ development0.059070.0005611InformativeInherited
Biological Process (BP)embryonic organ development0.011050.000000007113InformativeInherited
Biological Process (BP)regulation of response to external stimulus0.096440.0001994InformativeInherited
Biological Process (BP)regulation of locomotion0.18710InformativeInherited
Biological Process (BP)hematopoietic or lymphoid organ development0.0051370InformativeInherited
Biological Process (BP)multicellular organismal reproductive process0.091770.0008766InformativeInherited
Biological Process (BP)peptide metabolic process0.00000056830.005117InformativeInherited
Biological Process (BP)protein maturation0.00000072520.04819InformativeInherited
Biological Process (BP)reproductive structure development0.00012760.002425InformativeInherited
Biological Process (BP)organ morphogenesis0.11560.0000000002221InformativeInherited
Biological Process (BP)regulation of nervous system development0.060561InformativeInherited
Biological Process (BP)cellular component movement0.016320InformativeInherited
Biological Process (BP)anatomical structure formation involved in morphogenesis0.026280.000000001871InformativeInherited
Biological Process (BP)ovulation cycle process0.00000000067620Highly InformativeDirect
Biological Process (BP)regulation of peptidyl-tyrosine phosphorylation0.0000000011010.000000004797Highly InformativeDirect
Biological Process (BP)gonad development0.0000000092480.0000000000007259Highly InformativeDirect
Biological Process (BP)chemical homeostasis within a tissue0.000000011270.000000000000009016Highly InformativeDirect
Biological Process (BP)vascular process in circulatory system0.000000052560.0006184Highly InformativeDirect
Biological Process (BP)branching morphogenesis of an epithelial tube0.00000005290.0006159Highly InformativeDirect
Biological Process (BP)mammary gland alveolus development0.00000080170.00000009695Highly InformativeDirect
Biological Process (BP)cardiocyte differentiation0.0000036780.000000000000001913Highly InformativeDirect
Biological Process (BP)regulation of hematopoietic progenitor cell differentiation0.0000055890.00009142Highly InformativeDirect
Biological Process (BP)secretion by tissue0.0000091860.00006926Highly InformativeDirect
Biological Process (BP)regulation of transmembrane receptor protein serine/threonine kinase signaling pathway0.000011650Highly InformativeDirect
Biological Process (BP)kidney development0.000028640Highly InformativeDirect
Biological Process (BP)angiogenesis0.000075140Highly InformativeDirect
Biological Process (BP)positive regulation of transcription, DNA-templated0.00016090Highly InformativeDirect
Biological Process (BP)respiratory tube development0.00016730.0000000001026Highly InformativeDirect
Biological Process (BP)heart morphogenesis0.00017790.0000000000235Highly InformativeDirect
Biological Process (BP)positive regulation of cell migration0.00019150.0000000000004416Highly InformativeDirect
Biological Process (BP)positive regulation of response to external stimulus0.00021570.00000000005909Highly InformativeDirect
Biological Process (BP)pattern specification process0.0002860.00000000005281Highly InformativeDirect
Biological Process (BP)regulation of cell adhesion0.00039810Highly InformativeDirect
Biological Process (BP)inflammatory response0.00060770.0001177Highly InformativeDirect
Biological Process (BP)artery morphogenesis0.00080610.0006218Highly InformativeDirect
Biological Process (BP)positive regulation of response to wounding0.000028460.8302Highly InformativeInherited
Biological Process (BP)positive regulation of defense response0.00020571Highly InformativeInherited
Biological Process (BP)positive regulation of cytokine production0.48551Highly InformativeInherited
Biological Process (BP)erythrocyte differentiation0.14980.6596Highly InformativeInherited
Biological Process (BP)cardiac muscle tissue development0.00000019180.1393Highly InformativeInherited
Biological Process (BP)muscle fiber development0.000000030860.003276Highly InformativeInherited
Biological Process (BP)transmembrane receptor protein tyrosine kinase signaling pathway0.17391Highly InformativeInherited
Biological Process (BP)regulation of epithelial cell differentiation0.0025410.00008187Highly InformativeInherited
Biological Process (BP)eye morphogenesis0.00047941Highly InformativeInherited
Biological Process (BP)post-embryonic organ development0.0019951Highly InformativeInherited
Biological Process (BP)post-embryonic development0.081721Highly InformativeInherited
Biological Process (BP)respiratory system development0.0011680.00006596Highly InformativeInherited
Biological Process (BP)regulation of neural precursor cell proliferation0.00045480.1155Highly InformativeInherited
Biological Process (BP)positive regulation of neurogenesis0.057360.02122Highly InformativeInherited
Biological Process (BP)positive regulation of epithelial cell proliferation0.0018240Highly InformativeInherited
Biological Process (BP)development of primary female sexual characteristics0.14660.00000002778Highly InformativeInherited
Molecular Function (MF)binding0.00000058990Least InformativeDirect
Molecular Function (MF)anion binding0.024990.000007863Moderately InformativeInherited
Molecular Function (MF)carbohydrate derivative binding0.12760.003812Moderately InformativeInherited
Molecular Function (MF)receptor binding00InformativeDirect
Molecular Function (MF)sulfur compound binding0.000073180InformativeDirect
Molecular Function (MF)heparin binding0.00000011420Highly InformativeDirect
Molecular Function (MF)growth factor receptor binding0.16980.000002811Highly InformativeInherited
Molecular Function (MF)cytokine receptor binding0.85130.0000000288Highly InformativeInherited
Cellular Component (CC)extracellular region part0.000000000000002780Moderately InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) positive regulation of biological process 0 Least Informative Direct
Biological Process (BP) protein metabolic process 0.00000001886 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.00006891 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0003929 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.0001142 Least Informative Direct
Biological Process (BP) localization 0.00000002883 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.000004147 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.01082 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.266 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) reproductive process 0 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.0003172 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0 Moderately Informative Direct
Biological Process (BP) cell differentiation 0 Moderately Informative Direct
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0 Moderately Informative Direct
Biological Process (BP) organ development 0.00000000005336 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0 Moderately Informative Direct
Biological Process (BP) tissue development 0.000000000000003707 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0.0001008 Moderately Informative Direct
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.000000005619 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.000000000001358 Moderately Informative Direct
Biological Process (BP) regulation of phosphorus metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.000403 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0.0000008984 Moderately Informative Direct
Biological Process (BP) regulation of localization 0 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 0.000000000000005526 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.0000000000006748 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.000000000005128 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 0.0000000004177 Moderately Informative Direct
Biological Process (BP) organic substance transport 0.00005543 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0.0003604 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0.007942 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.7113 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.003945 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.21 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.01046 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.1702 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.0479 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.0226 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.478 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.1215 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.01954 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.05319 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.4018 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.4515 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) defense response 0.874 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.4546 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.00148 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.000000000002338 Informative Direct
Biological Process (BP) single organism reproductive process 0.0000000000004517 Informative Direct
Biological Process (BP) generation of neurons 0 Informative Direct
Biological Process (BP) regulation of protein phosphorylation 0 Informative Direct
Biological Process (BP) blood circulation 0.00000000000005029 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0 Informative Direct
Biological Process (BP) regulation of hormone levels 0.0001377 Informative Direct
Biological Process (BP) cell proliferation 0.0000000007652 Informative Direct
Biological Process (BP) growth 0.00000001034 Informative Direct
Biological Process (BP) positive regulation of developmental process 0 Informative Direct
Biological Process (BP) localization of cell 0 Informative Direct
Biological Process (BP) gland development 0.000001287 Informative Direct
Biological Process (BP) tube development 0 Informative Direct
Biological Process (BP) regulation of cell proliferation 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0 Informative Direct
Biological Process (BP) regulation of response to wounding 0.0005474 Informative Direct
Biological Process (BP) positive regulation of RNA metabolic process 0.00000000000003576 Informative Direct
Biological Process (BP) regulation of body fluid levels 0.0002254 Informative Direct
Biological Process (BP) hematopoietic or lymphoid organ development 0 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.000000000000544 Informative Direct
Biological Process (BP) negative regulation of cell death 0.00000000128 Informative Direct
Biological Process (BP) positive regulation of gene expression 0.0000000000001193 Informative Direct
Biological Process (BP) embryonic organ development 0.000000007113 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0.000000000005001 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.0000000000001712 Informative Direct
Biological Process (BP) cellular component movement 0 Informative Direct
Biological Process (BP) tissue morphogenesis 0.0000000005447 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.000000001871 Informative Direct
Biological Process (BP) cardiovascular system development 0 Informative Direct
Biological Process (BP) sensory organ development 0.0005611 Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0 Informative Direct
Biological Process (BP) multicellular organismal reproductive process 0.0008766 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0.0001994 Informative Direct
Biological Process (BP) organ morphogenesis 0.0000000002221 Informative Direct
Biological Process (BP) negative regulation of developmental process 0.000000001341 Informative Direct
Biological Process (BP) regulation of cellular component movement 0 Informative Direct
Biological Process (BP) regulation of locomotion 0 Informative Direct
Biological Process (BP) regulation of growth 0.0000000000003054 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 0 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 0.0000000002652 Informative Direct
Biological Process (BP) phosphorylation 0.000000000000005526 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.0000000000004545 Informative Direct
Biological Process (BP) positive regulation of transport 0.000000000002607 Informative Direct
Biological Process (BP) protein localization to organelle 0.000000000008102 Informative Direct
Biological Process (BP) apoptotic process 0.00000000003228 Informative Direct
Biological Process (BP) secretion by cell 0.00000000006211 Informative Direct
Biological Process (BP) regulation of transferase activity 0.000000002668 Informative Direct
Biological Process (BP) positive regulation of cell death 0.000000007003 Informative Direct
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.00000005417 Informative Direct
Biological Process (BP) cell projection organization 0.00000008562 Informative Direct
Biological Process (BP) response to nutrient levels 0.0000002845 Informative Direct
Biological Process (BP) negative regulation of signaling 0.0000009358 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.000003517 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.000008368 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.00001706 Informative Direct
Biological Process (BP) glycosyl compound biosynthetic process 0.00002381 Informative Direct
Biological Process (BP) ribose phosphate biosynthetic process 0.00002512 Informative Direct
Biological Process (BP) purine-containing compound biosynthetic process 0.00004312 Informative Direct
Biological Process (BP) regulation of secretion 0.0001216 Informative Direct
Biological Process (BP) lipid localization 0.0001918 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 0.0003372 Informative Direct
Biological Process (BP) cytoplasmic transport 0.0005149 Informative Direct
Biological Process (BP) negative regulation of biosynthetic process 0.0009257 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.00125 Informative Inherited
Biological Process (BP) regulation of protein localization 0.88 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.3098 Informative Inherited
Biological Process (BP) regulation of defense response 1 Informative Inherited
Biological Process (BP) regulation of ion transport 1 Informative Inherited
Biological Process (BP) epithelium development 0.3021 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.3992 Informative Inherited
Biological Process (BP) response to acid chemical 1 Informative Inherited
Biological Process (BP) response to bacterium 0.009852 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.001438 Informative Inherited
Biological Process (BP) regulation of cell development 0.1124 Informative Inherited
Biological Process (BP) muscle structure development 0.0183 Informative Inherited
Biological Process (BP) positive regulation of intracellular signal transduction 0.1408 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) response to lipid 0.00777 Informative Inherited
Biological Process (BP) neurological system process 1 Informative Inherited
Biological Process (BP) anatomical structure homeostasis 0.001627 Informative Inherited
Biological Process (BP) multicellular organismal homeostasis 0.08802 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.009742 Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 0.004043 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 1 Informative Inherited
Biological Process (BP) organic hydroxy compound biosynthetic process 0.1057 Informative Inherited
Biological Process (BP) purine ribonucleoside metabolic process 0.09956 Informative Inherited
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.4995 Informative Inherited
Biological Process (BP) single-organism cellular localization 0.09692 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 0.03006 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) regulation of MAPK cascade 0.001501 Informative Inherited
Biological Process (BP) cellular response to hormone stimulus 0.4797 Informative Inherited
Biological Process (BP) regulation of intracellular transport 1 Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.05934 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.0388 Informative Inherited
Biological Process (BP) negative regulation of transport 0.005357 Informative Inherited
Biological Process (BP) regulation of system process 0.001135 Informative Inherited
Biological Process (BP) cell division 1 Informative Inherited
Biological Process (BP) peptide metabolic process 0.005117 Informative Inherited
Biological Process (BP) protein maturation 0.04819 Informative Inherited
Biological Process (BP) muscle system process 0.8514 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.08397 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 1 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.384 Informative Inherited
Biological Process (BP) regulation of cell activation 0.00492 Informative Inherited
Biological Process (BP) nucleotide biosynthetic process 0.001669 Informative Inherited
Biological Process (BP) purine ribonucleotide metabolic process 0.1328 Informative Inherited
Biological Process (BP) reproductive structure development 0.002425 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 1 Informative Inherited
Biological Process (BP) regulation of cell cycle process 1 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) nucleoside monophosphate metabolic process 0.01191 Informative Inherited
Biological Process (BP) nucleoside triphosphate metabolic process 0.05742 Informative Inherited
Biological Process (BP) single-organism intracellular transport 0.6334 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.5865 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 0.1591 Informative Inherited
Biological Process (BP) regulation of immune effector process 1 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.09547 Informative Inherited
Biological Process (BP) cell cycle process 0.04151 Informative Inherited
Biological Process (BP) protein transport 0.5623 Informative Inherited
Biological Process (BP) ovulation cycle process 0 Highly Informative Direct
Biological Process (BP) regulation of peptidyl-tyrosine phosphorylation 0.000000004797 Highly Informative Direct
Biological Process (BP) gonad development 0.0000000000007259 Highly Informative Direct
Biological Process (BP) chemical homeostasis within a tissue 0.000000000000009016 Highly Informative Direct
Biological Process (BP) vascular process in circulatory system 0.0006184 Highly Informative Direct
Biological Process (BP) branching morphogenesis of an epithelial tube 0.0006159 Highly Informative Direct
Biological Process (BP) mammary gland alveolus development 0.00000009695 Highly Informative Direct
Biological Process (BP) cardiocyte differentiation 0.000000000000001913 Highly Informative Direct
Biological Process (BP) regulation of hematopoietic progenitor cell differentiation 0.00009142 Highly Informative Direct
Biological Process (BP) secretion by tissue 0.00006926 Highly Informative Direct
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0 Highly Informative Direct
Biological Process (BP) kidney development 0 Highly Informative Direct
Biological Process (BP) angiogenesis 0 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-templated 0 Highly Informative Direct
Biological Process (BP) respiratory tube development 0.0000000001026 Highly Informative Direct
Biological Process (BP) heart morphogenesis 0.0000000000235 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 0.0000000000004416 Highly Informative Direct
Biological Process (BP) positive regulation of response to external stimulus 0.00000000005909 Highly Informative Direct
Biological Process (BP) pattern specification process 0.00000000005281 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0 Highly Informative Direct
Biological Process (BP) inflammatory response 0.0001177 Highly Informative Direct
Biological Process (BP) artery morphogenesis 0.0006218 Highly Informative Direct
Biological Process (BP) respiratory system development 0.00006596 Highly Informative Direct
Biological Process (BP) positive regulation of epithelial cell proliferation 0 Highly Informative Direct
Biological Process (BP) regulation of epithelial cell differentiation 0.00008187 Highly Informative Direct
Biological Process (BP) mesenchyme development 0 Highly Informative Direct
Biological Process (BP) positive regulation of angiogenesis 0.0000000004078 Highly Informative Direct
Biological Process (BP) regulation of organ morphogenesis 0.0000000000001682 Highly Informative Direct
Biological Process (BP) development of primary female sexual characteristics 0.00000002778 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 0 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0 Highly Informative Direct
Biological Process (BP) hair cycle process 0 Highly Informative Direct
Biological Process (BP) skeletal system development 0 Highly Informative Direct
Biological Process (BP) ossification 0 Highly Informative Direct
Biological Process (BP) response to hypoxia 0 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 0 Highly Informative Direct
Biological Process (BP) protein phosphorylation 0 Highly Informative Direct
Biological Process (BP) chemotaxis 0.00000000000007734 Highly Informative Direct
Biological Process (BP) hormone transport 0.00000000000008049 Highly Informative Direct
Biological Process (BP) single-organism nuclear import 0.0000000000002045 Highly Informative Direct
Biological Process (BP) negative regulation of cell growth 0.0000000000007231 Highly Informative Direct
Biological Process (BP) positive regulation of behavior 0.0000000000008566 Highly Informative Direct
Biological Process (BP) regulation of chemotaxis 0.000000000002114 Highly Informative Direct
Biological Process (BP) purine ribonucleoside triphosphate biosynthetic process 0.000000000006724 Highly Informative Direct
Biological Process (BP) regulation of protein targeting 0.00000000002063 Highly Informative Direct
Biological Process (BP) stem cell development 0.0000000001281 Highly Informative Direct
Biological Process (BP) response to glucocorticoid 0.0000000002515 Highly Informative Direct
Biological Process (BP) aminoglycan catabolic process 0.0000000007966 Highly Informative Direct
Biological Process (BP) regulation of hormone secretion 0.000000001534 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 0.000000003602 Highly Informative Direct
Biological Process (BP) protein import 0.000000008196 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate biosynthetic process 0.00000001086 Highly Informative Direct
Biological Process (BP) protein targeting to nucleus 0.00000001115 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0.00000001691 Highly Informative Direct
Biological Process (BP) cell junction organization 0.0000001004 Highly Informative Direct
Biological Process (BP) glycosaminoglycan metabolic process 0.0000001088 Highly Informative Direct
Biological Process (BP) regulation of reproductive process 0.000000275 Highly Informative Direct
Biological Process (BP) positive regulation of homeostatic process 0.0000003446 Highly Informative Direct
Biological Process (BP) negative regulation of lipid biosynthetic process 0.0000005563 Highly Informative Direct
Biological Process (BP) regulation of nuclear division 0.0000006172 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0.000000932 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 0.000001227 Highly Informative Direct
Biological Process (BP) regulation of reactive oxygen species metabolic process 0.000003943 Highly Informative Direct
Biological Process (BP) regulation of cytokine biosynthetic process 0.00001359 Highly Informative Direct
Biological Process (BP) negative regulation of secretion by cell 0.0000183 Highly Informative Direct
Biological Process (BP) regulation of protein serine/threonine kinase activity 0.00002049 Highly Informative Direct
Biological Process (BP) cell fate commitment 0.00003175 Highly Informative Direct
Biological Process (BP) extrinsic apoptotic signaling pathway 0.00005418 Highly Informative Direct
Biological Process (BP) regulation of synaptic transmission 0.00008757 Highly Informative Direct
Biological Process (BP) connective tissue development 0.00009683 Highly Informative Direct
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 0.0001057 Highly Informative Direct
Biological Process (BP) mitotic cell cycle phase transition 0.0001065 Highly Informative Direct
Biological Process (BP) positive regulation of lipid metabolic process 0.0001483 Highly Informative Direct
Biological Process (BP) regulation of cytokine production involved in immune response 0.0001544 Highly Informative Direct
Biological Process (BP) regulation of protein complex assembly 0.0001991 Highly Informative Direct
Biological Process (BP) negative regulation of neuron death 0.0002084 Highly Informative Direct
Biological Process (BP) endocrine system development 0.0002125 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 0.0002301 Highly Informative Direct
Biological Process (BP) regulation of wound healing 0.0003851 Highly Informative Direct
Biological Process (BP) regulation of mononuclear cell proliferation 0.0005006 Highly Informative Direct
Biological Process (BP) exocytosis 0.0007428 Highly Informative Direct
Biological Process (BP) response to drug 0.0008231 Highly Informative Direct
Biological Process (BP) positive regulation of apoptotic signaling pathway 0.005544 Highly Informative Inherited
Biological Process (BP) regulation of binding 0.03154 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 1 Highly Informative Inherited
Biological Process (BP) positive regulation of response to wounding 0.8302 Highly Informative Inherited
Biological Process (BP) positive regulation of defense response 1 Highly Informative Inherited
Biological Process (BP) leukocyte migration 0.01981 Highly Informative Inherited
Biological Process (BP) regulation of calcium ion transport 0.01107 Highly Informative Inherited
Biological Process (BP) regulation of ion transmembrane transport 0.5401 Highly Informative Inherited
Biological Process (BP) positive regulation of ion transport 1 Highly Informative Inherited
Biological Process (BP) regulation of peptide transport 0.1387 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 1 Highly Informative Inherited
Biological Process (BP) cellular response to acid chemical 1 Highly Informative Inherited
Biological Process (BP) cellular response to biotic stimulus 0.001067 Highly Informative Inherited
Biological Process (BP) negative regulation of response to wounding 0.07008 Highly Informative Inherited
Biological Process (BP) signal release 0.311 Highly Informative Inherited
Biological Process (BP) erythrocyte differentiation 0.6596 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.6698 Highly Informative Inherited
Biological Process (BP) cardiac muscle tissue development 0.1393 Highly Informative Inherited
Biological Process (BP) regulation of amine transport 0.3035 Highly Informative Inherited
Biological Process (BP) modification of morphology or physiology of other organism 0.01442 Highly Informative Inherited
Biological Process (BP) negative regulation of cell division 0.03686 Highly Informative Inherited
Biological Process (BP) muscle fiber development 0.003276 Highly Informative Inherited
Biological Process (BP) regulation of endocytosis 0.004431 Highly Informative Inherited
Biological Process (BP) regulation of myeloid cell differentiation 0.02925 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.9051 Highly Informative Inherited
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.006768 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 0.00253 Highly Informative Inherited
Biological Process (BP) regulation of neuron apoptotic process 0.002019 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 0.04853 Highly Informative Inherited
Biological Process (BP) cellular response to steroid hormone stimulus 0.002377 Highly Informative Inherited
Biological Process (BP) hormone-mediated signaling pathway 0.7886 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 1 Highly Informative Inherited
Biological Process (BP) regulation of protein localization to nucleus 0.06987 Highly Informative Inherited
Biological Process (BP) regulation of nucleocytoplasmic transport 0.002652 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.7421 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 1 Highly Informative Inherited
Biological Process (BP) positive regulation of transmembrane transport 0.03972 Highly Informative Inherited
Biological Process (BP) negative regulation of leukocyte activation 0.06054 Highly Informative Inherited
Biological Process (BP) response to alcohol 0.09749 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 1 Highly Informative Inherited
Biological Process (BP) post-embryonic development 1 Highly Informative Inherited
Biological Process (BP) negative regulation of hemostasis 0.002298 Highly Informative Inherited
Biological Process (BP) wound healing 0.04851 Highly Informative Inherited
Biological Process (BP) coagulation 0.1465 Highly Informative Inherited
Biological Process (BP) hemostasis 1 Highly Informative Inherited
Biological Process (BP) multi-organism cellular process 0.02018 Highly Informative Inherited
Biological Process (BP) negative regulation of immune response 0.06239 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.3571 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 1 Highly Informative Inherited
Biological Process (BP) negative regulation of coagulation 0.004828 Highly Informative Inherited
Biological Process (BP) neuron projection development 1 Highly Informative Inherited
Biological Process (BP) cell projection morphogenesis 1 Highly Informative Inherited
Biological Process (BP) nuclear export 0.1599 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.1406 Highly Informative Inherited
Biological Process (BP) regulation of blood pressure 0.179 Highly Informative Inherited
Biological Process (BP) negative regulation of cytokine production 0.01293 Highly Informative Inherited
Biological Process (BP) negative regulation of immune effector process 0.02461 Highly Informative Inherited
Biological Process (BP) columnar/cuboidal epithelial cell differentiation 0.1499 Highly Informative Inherited
Biological Process (BP) regulation of neural precursor cell proliferation 0.1155 Highly Informative Inherited
Biological Process (BP) positive regulation of neurogenesis 0.02122 Highly Informative Inherited
Biological Process (BP) epidermis development 0.05856 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) anion binding 0.000007863 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0.00007409 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.003812 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) receptor binding 0 Informative Direct
Molecular Function (MF) sulfur compound binding 0 Informative Direct
Molecular Function (MF) protein dimerization activity 0.000000000001281 Informative Direct
Molecular Function (MF) enzyme activator activity 0.000000002341 Informative Direct
Molecular Function (MF) amide binding 0.04552 Informative Inherited
Molecular Function (MF) protein complex binding 1 Informative Inherited
Molecular Function (MF) molecular transducer activity 0.9474 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1 Informative Inherited
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) heparin binding 0 Highly Informative Direct
Molecular Function (MF) growth factor receptor binding 0.000002811 Highly Informative Direct
Molecular Function (MF) cytokine receptor binding 0.0000000288 Highly Informative Direct
Molecular Function (MF) phosphatase regulator activity 0.00000000002651 Highly Informative Direct
Molecular Function (MF) cytokine activity 0.000000007335 Highly Informative Direct
Molecular Function (MF) protein homodimerization activity 0.000003614 Highly Informative Direct
Molecular Function (MF) peptide binding 0.0002101 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0.9628 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0.00000000000002168 Moderately Informative Direct
Cellular Component (CC) cell projection 0.000745 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 0.4774 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) extracellular space 0 Informative Direct
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) secretory granule 0 Informative Direct
Cellular Component (CC) extracellular matrix 0.000000000000135 Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.00000000006649 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

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DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.1554Least InformativeInherited
Disease Ontology (DO)immune system disease0.4665Least InformativeInherited
Disease Ontology (DO)nervous system disease0.4759Least InformativeInherited
Disease Ontology (DO)benign neoplasm0.00000009987Moderately InformativeDirect
Disease Ontology (DO)urinary system disease0.03075Moderately InformativeInherited
Disease Ontology (DO)endocrine system disease0.04417Moderately InformativeInherited
Disease Ontology (DO)sensory system disease0.06785Moderately InformativeInherited
Disease Ontology (DO)mouth disease0.07096Moderately InformativeInherited
Disease Ontology (DO)connective tissue disease0.2041Moderately InformativeInherited
Disease Ontology (DO)hematologic cancer0.246Moderately InformativeInherited
Disease Ontology (DO)obstructive lung disease0.4005Moderately InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.5735Moderately InformativeInherited
Disease Ontology (DO)prostate cancer0.00004638InformativeDirect
Disease Ontology (DO)glomerulonephritis0.0005016InformativeDirect
Disease Ontology (DO)arthropathy0.003755InformativeInherited
Disease Ontology (DO)myeloma0.004198InformativeInherited
Disease Ontology (DO)integumentary system cancer0.02363InformativeInherited
Disease Ontology (DO)auditory system disease0.0258InformativeInherited
Disease Ontology (DO)endocrine gland cancer0.0599InformativeInherited
Disease Ontology (DO)asthma0.109InformativeInherited
Disease Ontology (DO)organ system benign neoplasm0.2196InformativeInherited
Disease Ontology (DO)labyrinthine disease0.0001159Highly InformativeDirect
Disease Ontology (DO)rhabdomyosarcoma0.0002631Highly InformativeDirect
Disease Ontology (DO)aggressive systemic mastocytosis0.0007931Highly InformativeDirect
Disease Ontology (DO)skin carcinoma0.002994Highly InformativeInherited
Disease Ontology (DO)colonic disease0.01025Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

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