SUPERFAMILY 1.75 HMM library and genome assignments server


Cystine-knot cytokines superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Cystine-knot cytokines [ 57500]
Superfamily:   Cystine-knot cytokines [ 57501] (7)
Families:   Platelet-derived growth factor-like [ 57502] (3)
  Transforming growth factor (TGF)-beta [ 57507] (7)
  Noggin [ 82904]
  Neurotrophin [ 57520] (4)
  Gonadodropin/Follitropin [ 57528] (3)
  Interleukin 17F, IL-17F [ 69955]
  Coagulogen [ 57531]


Superfamily statistics
Genomes (135) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 5,762 14,377 40
Proteins 5,735 14,339 40


Functional annotation
General category Processes_IC
Detailed category Cell cycle, Apoptosis

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus4.137e-120Least InformativeDirect
Biological Process (BP)developmental process1.138e-100Least InformativeDirect
Biological Process (BP)multicellular organismal process3.875e-090Least InformativeDirect
Biological Process (BP)single-organism cellular process2.497e-053.722e-15Least InformativeDirect
Biological Process (BP)regulation of cellular process0.16233.745e-05Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.92680.0002806Least InformativeInherited
Biological Process (BP)localization0.59267.04e-10Least InformativeInherited
Biological Process (BP)protein metabolic process0.075361.209e-09Least InformativeInherited
Biological Process (BP)reproduction1.481e-080Moderately InformativeDirect
Biological Process (BP)response to organic substance2.872e-080.0002234Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process4.399e-060Moderately InformativeDirect
Biological Process (BP)cell differentiation0.00014560Moderately InformativeDirect
Biological Process (BP)single-organism developmental process0.00038920Moderately InformativeDirect
Biological Process (BP)immune system process0.00042550Moderately InformativeDirect
Biological Process (BP)regulation of developmental process0.00062320Moderately InformativeDirect
Biological Process (BP)regulation of localization10Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.33690.0003372Moderately InformativeInherited
Biological Process (BP)tissue development0.068244.724e-14Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.13571.336e-13Moderately InformativeInherited
Biological Process (BP)organ development0.010492.991e-09Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.050210Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.10230Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.048930.8085Moderately InformativeInherited
Biological Process (BP)signal transduction0.12710Moderately InformativeInherited
Biological Process (BP)system process0.37090.6803Moderately InformativeInherited
Biological Process (BP)homeostatic process0.63141Moderately InformativeInherited
Biological Process (BP)gene expression0.009991Moderately InformativeInherited
Biological Process (BP)regulation of biosynthetic process0.022161.983e-07Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.29831Moderately InformativeInherited
Biological Process (BP)nervous system development0.73410.9659Moderately InformativeInherited
Biological Process (BP)regulation of transcription from RNA polymerase II promoter2.869e-094.027e-13InformativeDirect
Biological Process (BP)generation of neurons4.404e-060InformativeDirect
Biological Process (BP)blood circulation8.949e-061.761e-14InformativeDirect
Biological Process (BP)response to wounding1.827e-053.722e-15InformativeDirect
Biological Process (BP)growth2.622e-057.82e-11InformativeDirect
Biological Process (BP)single organism reproductive process0.00012428.552e-09InformativeDirect
Biological Process (BP)gland development0.00014289.717e-08InformativeDirect
Biological Process (BP)tube development0.00015680InformativeDirect
Biological Process (BP)regulation of hormone levels0.00015870.0001336InformativeDirect
Biological Process (BP)positive regulation of developmental process0.00016190InformativeDirect
Biological Process (BP)positive regulation of gene expression0.00032510InformativeDirect
Biological Process (BP)localization of cell0.00036020InformativeDirect
Biological Process (BP)locomotion0.0005080InformativeDirect
Biological Process (BP)regulation of cell proliferation0.00053780InformativeDirect
Biological Process (BP)enzyme linked receptor protein signaling pathway0.00073810InformativeDirect
Biological Process (BP)regulation of anatomical structure morphogenesis0.0062572.633e-13InformativeInherited
Biological Process (BP)regulation of response to external stimulus0.07498.71e-07InformativeInherited
Biological Process (BP)regulation of cytokine production0.24380.04251InformativeInherited
Biological Process (BP)regulation of response to stress0.29451InformativeInherited
Biological Process (BP)positive regulation of multicellular organismal process0.0035320InformativeInherited
Biological Process (BP)epithelium development0.64031InformativeInherited
Biological Process (BP)positive regulation of nitrogen compound metabolic process0.0029920InformativeInherited
Biological Process (BP)cardiovascular system development0.036860InformativeInherited
Biological Process (BP)muscle tissue development0.016040.2344InformativeInherited
Biological Process (BP)muscle structure development0.027860.04284InformativeInherited
Biological Process (BP)positive regulation of macromolecule biosynthetic process0.0020557.281e-15InformativeInherited
Biological Process (BP)positive regulation of cellular biosynthetic process0.0031881.448e-10InformativeInherited
Biological Process (BP)multicellular organismal reproductive process0.14528.029e-05InformativeInherited
Biological Process (BP)sensory organ development0.072940.001239InformativeInherited
Biological Process (BP)organ morphogenesis0.14272.063e-10InformativeInherited
Biological Process (BP)embryonic organ development0.014021.262e-07InformativeInherited
Biological Process (BP)regulation of cellular component movement0.16090InformativeInherited
Biological Process (BP)regulation of locomotion0.17820InformativeInherited
Biological Process (BP)hematopoietic or lymphoid organ development0.0073620InformativeInherited
Biological Process (BP)cellular component movement0.091570InformativeInherited
Biological Process (BP)regulation of body fluid levels0.0031430.0001805InformativeInherited
Biological Process (BP)regulation of cell development0.047740.436InformativeInherited
Biological Process (BP)regulation of nervous system development0.059311InformativeInherited
Biological Process (BP)tissue morphogenesis0.031541.977e-09InformativeInherited
Biological Process (BP)reproductive system development5.941e-050.04049InformativeInherited
Biological Process (BP)developmental process involved in reproduction0.004050.06105InformativeInherited
Biological Process (BP)anatomical structure formation involved in morphogenesis0.023736.294e-10InformativeInherited
Biological Process (BP)gonad development7.757e-091.023e-12Highly InformativeDirect
Biological Process (BP)ovulation cycle process1.174e-080Highly InformativeDirect
Biological Process (BP)protein processing1.325e-080.0002613Highly InformativeDirect
Biological Process (BP)vascular process in circulatory system2.856e-080.000591Highly InformativeDirect
Biological Process (BP)branching morphogenesis of an epithelial tube3.688e-080.0006767Highly InformativeDirect
Biological Process (BP)mammary gland alveolus development8.76e-078.994e-08Highly InformativeDirect
Biological Process (BP)tissue homeostasis1.488e-063.762e-07Highly InformativeDirect
Biological Process (BP)cardiocyte differentiation3.845e-063.722e-15Highly InformativeDirect
Biological Process (BP)lactation6.939e-054.176e-05Highly InformativeDirect
Biological Process (BP)angiogenesis7.673e-050Highly InformativeDirect
Biological Process (BP)renal system development0.00011574.924e-13Highly InformativeDirect
Biological Process (BP)positive regulation of cell migration0.00013935.951e-13Highly InformativeDirect
Biological Process (BP)heart morphogenesis0.00016054.237e-11Highly InformativeDirect
Biological Process (BP)respiratory tube development0.00026252.497e-10Highly InformativeDirect
Biological Process (BP)pattern specification process0.00027861.115e-11Highly InformativeDirect
Biological Process (BP)positive regulation of transcription, DNA-dependent0.00028550Highly InformativeDirect
Biological Process (BP)artery morphogenesis0.00083570.000694Highly InformativeDirect
Biological Process (BP)positive regulation of cytokine production0.10481Highly InformativeInherited
Biological Process (BP)respiratory system development0.0012126.699e-05Highly InformativeInherited
Biological Process (BP)erythrocyte differentiation0.13780.6218Highly InformativeInherited
Biological Process (BP)cardiac muscle tissue development9.627e-080.03383Highly InformativeInherited
Biological Process (BP)muscle fiber development1.324e-070.1932Highly InformativeInherited
Biological Process (BP)transmembrane receptor protein tyrosine kinase signaling pathway0.18621Highly InformativeInherited
Biological Process (BP)photoreceptor cell differentiation7.492e-080.1143Highly InformativeInherited
Biological Process (BP)eye morphogenesis0.00042721Highly InformativeInherited
Biological Process (BP)post-embryonic organ development0.0024121Highly InformativeInherited
Biological Process (BP)post-embryonic development0.078911Highly InformativeInherited
Biological Process (BP)regulation of neural precursor cell proliferation0.00049170.1026Highly InformativeInherited
Biological Process (BP)positive regulation of cell differentiation0.0071020Highly InformativeInherited
Biological Process (BP)positive regulation of epithelial cell proliferation0.0020580Highly InformativeInherited
Biological Process (BP)development of primary female sexual characteristics0.36290.0001302Highly InformativeInherited
Molecular Function (MF)binding2.365e-070Least InformativeDirect
Molecular Function (MF)anion binding0.017682.374e-06Moderately InformativeInherited
Molecular Function (MF)receptor binding00InformativeDirect
Molecular Function (MF)sulfur compound binding3.356e-050InformativeDirect
Molecular Function (MF)carbohydrate derivative binding4.704e-050InformativeDirect
Molecular Function (MF)heparin binding8.316e-080Highly InformativeDirect
Molecular Function (MF)growth factor receptor binding0.1542.02e-06Highly InformativeInherited
Molecular Function (MF)cytokine receptor binding0.81916.509e-08Highly InformativeInherited
Cellular Component (CC)extracellular region part00Moderately InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 3.722e-15 Least Informative Direct
Biological Process (BP) protein metabolic process 1.209e-09 Least Informative Direct
Biological Process (BP) regulation of cellular process 3.745e-05 Least Informative Direct
Biological Process (BP) localization 7.04e-10 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.0002806 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 8.979e-08 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.1488 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.002972 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) reproduction 0 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.0002234 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0 Moderately Informative Direct
Biological Process (BP) cell differentiation 0 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 0 Moderately Informative Direct
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0 Moderately Informative Direct
Biological Process (BP) organ development 2.991e-09 Moderately Informative Direct
Biological Process (BP) regulation of biosynthetic process 1.983e-07 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0 Moderately Informative Direct
Biological Process (BP) tissue development 4.724e-14 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 5.072e-08 Moderately Informative Direct
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 1.336e-13 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.0003372 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 0 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 3.095e-14 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 1.249e-12 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 1.485e-12 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 4.893e-10 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 6.24e-05 Moderately Informative Direct
Biological Process (BP) organic substance transport 0.0001156 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.8085 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.1811 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.04111 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.066 Moderately Informative Inherited
Biological Process (BP) system process 0.6803 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.001903 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.01862 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.082 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.9659 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.08507 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.07025 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.271 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.3098 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.9786 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.984 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.7733 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.4215 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.3133 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.001643 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 4.027e-13 Informative Direct
Biological Process (BP) generation of neurons 0 Informative Direct
Biological Process (BP) blood circulation 1.761e-14 Informative Direct
Biological Process (BP) response to wounding 3.722e-15 Informative Direct
Biological Process (BP) growth 7.82e-11 Informative Direct
Biological Process (BP) single organism reproductive process 8.552e-09 Informative Direct
Biological Process (BP) gland development 9.717e-08 Informative Direct
Biological Process (BP) tube development 0 Informative Direct
Biological Process (BP) regulation of hormone levels 0.0001336 Informative Direct
Biological Process (BP) positive regulation of developmental process 0 Informative Direct
Biological Process (BP) positive regulation of gene expression 0 Informative Direct
Biological Process (BP) localization of cell 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) regulation of cell proliferation 0 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0 Informative Direct
Biological Process (BP) negative regulation of cell death 1.694e-10 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 7.281e-15 Informative Direct
Biological Process (BP) cell-cell signaling 1.253e-07 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0 Informative Direct
Biological Process (BP) regulation of body fluid levels 0.0001805 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 1.448e-10 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 2.633e-13 Informative Direct
Biological Process (BP) hematopoietic or lymphoid organ development 0 Informative Direct
Biological Process (BP) embryonic organ development 1.262e-07 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 6.294e-10 Informative Direct
Biological Process (BP) tissue morphogenesis 1.977e-09 Informative Direct
Biological Process (BP) cardiovascular system development 0 Informative Direct
Biological Process (BP) regulation of response to external stimulus 8.71e-07 Informative Direct
Biological Process (BP) cellular component movement 0 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 1.357e-09 Informative Direct
Biological Process (BP) negative regulation of developmental process 1.678e-09 Informative Direct
Biological Process (BP) organ morphogenesis 2.063e-10 Informative Direct
Biological Process (BP) multicellular organismal reproductive process 8.029e-05 Informative Direct
Biological Process (BP) regulation of growth 1.922e-15 Informative Direct
Biological Process (BP) regulation of cellular component movement 0 Informative Direct
Biological Process (BP) regulation of locomotion 0 Informative Direct
Biological Process (BP) positive regulation of signal transduction 0 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 0 Informative Direct
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) positive regulation of protein modification process 0 Informative Direct
Biological Process (BP) regulation of establishment of protein localization 0 Informative Direct
Biological Process (BP) regulation of protein phosphorylation 6.578e-13 Informative Direct
Biological Process (BP) positive regulation of transport 1.849e-12 Informative Direct
Biological Process (BP) protein localization to organelle 2.139e-12 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 7.667e-12 Informative Direct
Biological Process (BP) secretion by cell 4.642e-09 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 5.684e-07 Informative Direct
Biological Process (BP) response to nutrient levels 9.067e-06 Informative Direct
Biological Process (BP) cell projection organization 1.243e-05 Informative Direct
Biological Process (BP) ribose phosphate biosynthetic process 1.381e-05 Informative Direct
Biological Process (BP) cellular component morphogenesis 1.587e-05 Informative Direct
Biological Process (BP) glycosyl compound biosynthetic process 1.701e-05 Informative Direct
Biological Process (BP) purine-containing compound biosynthetic process 2.592e-05 Informative Direct
Biological Process (BP) regulation of secretion 0.0001169 Informative Direct
Biological Process (BP) lipid localization 0.0001538 Informative Direct
Biological Process (BP) cytoplasmic transport 0.0001587 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 0.0002701 Informative Direct
Biological Process (BP) cellular process involved in reproduction 0.0009648 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 0.0009861 Informative Direct
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.1387 Informative Inherited
Biological Process (BP) regulation of response to stress 1 Informative Inherited
Biological Process (BP) programmed cell death 0.2949 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.09438 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.02928 Informative Inherited
Biological Process (BP) response to lipid 0.004408 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.001936 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.3152 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.001712 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.001359 Informative Inherited
Biological Process (BP) sensory organ development 0.001239 Informative Inherited
Biological Process (BP) muscle tissue development 0.2344 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.8408 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) muscle structure development 0.04284 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.01914 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.05201 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.06105 Informative Inherited
Biological Process (BP) organic hydroxy compound biosynthetic process 0.08405 Informative Inherited
Biological Process (BP) purine ribonucleoside metabolic process 0.09366 Informative Inherited
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 0.02269 Informative Inherited
Biological Process (BP) protein complex assembly 0.0265 Informative Inherited
Biological Process (BP) regulation of kinase activity 1 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 1 Informative Inherited
Biological Process (BP) regulation of intracellular transport 1 Informative Inherited
Biological Process (BP) regulation of ion transport 1 Informative Inherited
Biological Process (BP) regulation of system process 0.00138 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 0.1232 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.007946 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.02567 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.1507 Informative Inherited
Biological Process (BP) response to other organism 0.09747 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) muscle system process 0.4773 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 1 Informative Inherited
Biological Process (BP) regulation of cell development 0.436 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.932 Informative Inherited
Biological Process (BP) nucleoside triphosphate metabolic process 0.05404 Informative Inherited
Biological Process (BP) nucleoside monophosphate metabolic process 0.01214 Informative Inherited
Biological Process (BP) purine ribonucleotide metabolic process 0.1299 Informative Inherited
Biological Process (BP) single-organism behavior 0.04839 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 1 Informative Inherited
Biological Process (BP) regulation of cell cycle process 1 Informative Inherited
Biological Process (BP) cell cycle process 0.1711 Informative Inherited
Biological Process (BP) protein transport 0.6187 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.04251 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.8981 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) reproductive system development 0.04049 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.9611 Informative Inherited
Biological Process (BP) gonad development 1.023e-12 Highly Informative Direct
Biological Process (BP) ovulation cycle process 0 Highly Informative Direct
Biological Process (BP) protein processing 0.0002613 Highly Informative Direct
Biological Process (BP) vascular process in circulatory system 0.000591 Highly Informative Direct
Biological Process (BP) branching morphogenesis of an epithelial tube 0.0006767 Highly Informative Direct
Biological Process (BP) mammary gland alveolus development 8.994e-08 Highly Informative Direct
Biological Process (BP) tissue homeostasis 3.762e-07 Highly Informative Direct
Biological Process (BP) cardiocyte differentiation 3.722e-15 Highly Informative Direct
Biological Process (BP) lactation 4.176e-05 Highly Informative Direct
Biological Process (BP) angiogenesis 0 Highly Informative Direct
Biological Process (BP) renal system development 4.924e-13 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 5.951e-13 Highly Informative Direct
Biological Process (BP) heart morphogenesis 4.237e-11 Highly Informative Direct
Biological Process (BP) respiratory tube development 2.497e-10 Highly Informative Direct
Biological Process (BP) pattern specification process 1.115e-11 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-dependent 0 Highly Informative Direct
Biological Process (BP) artery morphogenesis 0.000694 Highly Informative Direct
Biological Process (BP) respiratory system development 6.699e-05 Highly Informative Direct
Biological Process (BP) positive regulation of epithelial cell proliferation 0 Highly Informative Direct
Biological Process (BP) mesenchyme development 0 Highly Informative Direct
Biological Process (BP) regulation of angiogenesis 0.0001873 Highly Informative Direct
Biological Process (BP) developmental maturation 2.071e-06 Highly Informative Direct
Biological Process (BP) positive regulation of cell differentiation 0 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 4.812e-09 Highly Informative Direct
Biological Process (BP) regulation of organ morphogenesis 4.075e-14 Highly Informative Direct
Biological Process (BP) development of primary female sexual characteristics 0.0001302 Highly Informative Direct
Biological Process (BP) protein phosphorylation 0 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0 Highly Informative Direct
Biological Process (BP) protein localization to nucleus 0 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 0 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0 Highly Informative Direct
Biological Process (BP) ossification 0 Highly Informative Direct
Biological Process (BP) response to hypoxia 0 Highly Informative Direct
Biological Process (BP) skeletal system development 0 Highly Informative Direct
Biological Process (BP) negative regulation of cell cycle 0 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 0 Highly Informative Direct
Biological Process (BP) hair follicle development 0 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0 Highly Informative Direct
Biological Process (BP) hormone transport 2.434e-14 Highly Informative Direct
Biological Process (BP) regulation of cell growth 3.915e-14 Highly Informative Direct
Biological Process (BP) protein targeting to nucleus 8.856e-14 Highly Informative Direct
Biological Process (BP) chemotaxis 1.043e-13 Highly Informative Direct
Biological Process (BP) negative regulation of growth 3.306e-12 Highly Informative Direct
Biological Process (BP) regulation of synaptic transmission 4.552e-12 Highly Informative Direct
Biological Process (BP) regulation of behavior 6.955e-12 Highly Informative Direct
Biological Process (BP) interphase 2.851e-11 Highly Informative Direct
Biological Process (BP) nuclear import 2.927e-11 Highly Informative Direct
Biological Process (BP) regulation of MAP kinase activity 7.519e-11 Highly Informative Direct
Biological Process (BP) stem cell development 1.106e-10 Highly Informative Direct
Biological Process (BP) aminoglycan catabolic process 4.39e-10 Highly Informative Direct
Biological Process (BP) regulation of hormone secretion 6.361e-10 Highly Informative Direct
Biological Process (BP) protein import 2.365e-09 Highly Informative Direct
Biological Process (BP) mitotic cell cycle phase transition 3.61e-09 Highly Informative Direct
Biological Process (BP) positive regulation of response to external stimulus 4.632e-09 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate biosynthetic process 7.677e-09 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 1.814e-08 Highly Informative Direct
Biological Process (BP) regulation of production of molecular mediator of immune response 4.384e-08 Highly Informative Direct
Biological Process (BP) glycosaminoglycan metabolic process 4.672e-08 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 2.313e-07 Highly Informative Direct
Biological Process (BP) negative regulation of lipid biosynthetic process 4.285e-07 Highly Informative Direct
Biological Process (BP) purine ribonucleotide biosynthetic process 1.313e-06 Highly Informative Direct
Biological Process (BP) cell junction organization 1.461e-06 Highly Informative Direct
Biological Process (BP) regulation of wound healing 2.591e-06 Highly Informative Direct
Biological Process (BP) positive regulation of protein secretion 5.158e-06 Highly Informative Direct
Biological Process (BP) female pregnancy 6.084e-06 Highly Informative Direct
Biological Process (BP) positive regulation of MAPK cascade 6.462e-06 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 7.311e-06 Highly Informative Direct
Biological Process (BP) regulation of cytokine biosynthetic process 1.426e-05 Highly Informative Direct
Biological Process (BP) regulation of reproductive process 1.789e-05 Highly Informative Direct
Biological Process (BP) regulation of mitosis 1.913e-05 Highly Informative Direct
Biological Process (BP) negative regulation of mitotic cell cycle phase transition 2.762e-05 Highly Informative Direct
Biological Process (BP) connective tissue development 4.322e-05 Highly Informative Direct
Biological Process (BP) cell fate commitment 5.34e-05 Highly Informative Direct
Biological Process (BP) extrinsic apoptotic signaling pathway 5.445e-05 Highly Informative Direct
Biological Process (BP) regulation of protein complex assembly 0.0001002 Highly Informative Direct
Biological Process (BP) nuclear export 0.0001642 Highly Informative Direct
Biological Process (BP) learning or memory 0.0002095 Highly Informative Direct
Biological Process (BP) endocrine system development 0.0002205 Highly Informative Direct
Biological Process (BP) negative regulation of neuron death 0.0003519 Highly Informative Direct
Biological Process (BP) regulation of mononuclear cell proliferation 0.0003529 Highly Informative Direct
Biological Process (BP) regulation of nucleocytoplasmic transport 0.0003813 Highly Informative Direct
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.0005685 Highly Informative Direct
Biological Process (BP) exocytosis 0.0006684 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0.00071 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 0.0007258 Highly Informative Direct
Biological Process (BP) peptidyl-serine modification 0.0007946 Highly Informative Direct
Biological Process (BP) cellular response to starvation 0.0008325 Highly Informative Direct
Biological Process (BP) positive regulation of lipid metabolic process 0.0008336 Highly Informative Direct
Biological Process (BP) response to drug 0.0009709 Highly Informative Direct
Biological Process (BP) positive regulation of apoptotic signaling pathway 0.005984 Highly Informative Inherited
Biological Process (BP) regulation of binding 0.01704 Highly Informative Inherited
Biological Process (BP) positive regulation of peptidyl-tyrosine phosphorylation 0.002397 Highly Informative Inherited
Biological Process (BP) regulation of hemostasis 0.01264 Highly Informative Inherited
Biological Process (BP) positive regulation of ion transport 1 Highly Informative Inherited
Biological Process (BP) regulation of calcium ion transport 0.05107 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.7063 Highly Informative Inherited
Biological Process (BP) cellular response to steroid hormone stimulus 0.001492 Highly Informative Inherited
Biological Process (BP) cellular response to alcohol 0.6496 Highly Informative Inherited
Biological Process (BP) response to corticosteroid stimulus 1 Highly Informative Inherited
Biological Process (BP) response to lipopolysaccharide 0.01105 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic process 0.03324 Highly Informative Inherited
Biological Process (BP) regulation of protein localization to nucleus 0.0875 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.1961 Highly Informative Inherited
Biological Process (BP) erythrocyte differentiation 0.6218 Highly Informative Inherited
Biological Process (BP) regulation of striated muscle tissue development 0.5401 Highly Informative Inherited
Biological Process (BP) regulation of protein kinase B signaling cascade 0.005967 Highly Informative Inherited
Biological Process (BP) regulation of amine transport 0.3296 Highly Informative Inherited
Biological Process (BP) cardiac muscle tissue development 0.03383 Highly Informative Inherited
Biological Process (BP) muscle fiber development 0.1932 Highly Informative Inherited
Biological Process (BP) negative regulation of secretion 0.06163 Highly Informative Inherited
Biological Process (BP) regulation of peptide transport 0.1692 Highly Informative Inherited
Biological Process (BP) regulation of myeloid cell differentiation 0.02398 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 0.9098 Highly Informative Inherited
Biological Process (BP) hormone-mediated signaling pathway 0.8039 Highly Informative Inherited
Biological Process (BP) photoreceptor cell differentiation 0.1143 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 1 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.002557 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 1 Highly Informative Inherited
Biological Process (BP) signal release 0.1653 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.3201 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.7612 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.8705 Highly Informative Inherited
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 0.001517 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 1 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 1 Highly Informative Inherited
Biological Process (BP) post-embryonic development 1 Highly Informative Inherited
Biological Process (BP) wound healing 0.04993 Highly Informative Inherited
Biological Process (BP) coagulation 0.115 Highly Informative Inherited
Biological Process (BP) hemostasis 1 Highly Informative Inherited
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.002301 Highly Informative Inherited
Biological Process (BP) modification of morphology or physiology of other organism 0.01359 Highly Informative Inherited
Biological Process (BP) multi-organism cellular process 0.01281 Highly Informative Inherited
Biological Process (BP) cell division 0.728 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.1628 Highly Informative Inherited
Biological Process (BP) regulation of coagulation 0.01875 Highly Informative Inherited
Biological Process (BP) axon development 0.3428 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in neuron differentiation 1 Highly Informative Inherited
Biological Process (BP) cell projection morphogenesis 1 Highly Informative Inherited
Biological Process (BP) ATP metabolic process 0.004825 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.4178 Highly Informative Inherited
Biological Process (BP) regulation of blood pressure 0.1784 Highly Informative Inherited
Biological Process (BP) regulation of endocytosis 0.003342 Highly Informative Inherited
Biological Process (BP) regulation of neural precursor cell proliferation 0.1026 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) anion binding 2.374e-06 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0.0005504 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) receptor binding 0 Informative Direct
Molecular Function (MF) sulfur compound binding 0 Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0 Informative Direct
Molecular Function (MF) protein dimerization activity 1.166e-12 Informative Direct
Molecular Function (MF) enzyme activator activity 6.473e-10 Informative Direct
Molecular Function (MF) amide binding 0.04517 Informative Inherited
Molecular Function (MF) molecular transducer activity 0.9388 Informative Inherited
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1 Informative Inherited
Molecular Function (MF) heparin binding 0 Highly Informative Direct
Molecular Function (MF) growth factor receptor binding 2.02e-06 Highly Informative Direct
Molecular Function (MF) cytokine receptor binding 6.509e-08 Highly Informative Direct
Molecular Function (MF) phosphatase regulator activity 1.6e-12 Highly Informative Direct
Molecular Function (MF) cytokine activity 2.07e-08 Highly Informative Direct
Molecular Function (MF) protein homodimerization activity 1.868e-06 Highly Informative Direct
Molecular Function (MF) peptide binding 0.0001376 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0.9255 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0.0001449 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 0.3998 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) extracellular matrix 4.674e-13 Informative Direct
Cellular Component (CC) secretory granule 6.059e-12 Informative Direct
Cellular Component (CC) microvillus 6.161e-15 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 1.588e-11 Highly Informative Direct
Cellular Component (CC) cell body 0.001597 Highly Informative Inherited

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.1257Least InformativeInherited
Disease Ontology (DO)benign neoplasm1.519e-07Moderately InformativeDirect
Disease Ontology (DO)lung disease0.0005777Moderately InformativeDirect
Disease Ontology (DO)musculoskeletal system disease0.009781Moderately InformativeInherited
Disease Ontology (DO)skin disease0.06802Moderately InformativeInherited
Disease Ontology (DO)endocrine system disease0.09031Moderately InformativeInherited
Disease Ontology (DO)hematologic cancer0.3816Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.7375Moderately InformativeInherited
Disease Ontology (DO)prostate cancer0.0003699InformativeDirect
Disease Ontology (DO)arthropathy0.003213InformativeInherited
Disease Ontology (DO)myeloma0.01555InformativeInherited
Disease Ontology (DO)organ system benign neoplasm0.2064InformativeInherited
Disease Ontology (DO)colonic disease0.006243Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Multifactorial inheritance7.163e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.04035Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of head and neck0.1114Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hand0.007641Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digit0.04354Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.9265Moderately InformativeInherited
Phenotypic Abnormality (PA)Aplasia/hypoplasia involving bones of the lower limbs0.03614InformativeInherited
Phenotypic Abnormality (PA)Abnormal facial shape0.2067InformativeInherited
Phenotypic Abnormality (PA)Abnormality of toe0.5334InformativeInherited
Phenotypic Abnormality (PA)Abnormality of phalanx of finger0.91InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the middle phalanges of the hand4.274e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Facial asymmetry0.000184Highly InformativeDirect
Phenotypic Abnormality (PA)Broad toe0.001483Highly InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia of toe0.003691Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the phalanges of the toes0.008225Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hallux0.01663Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the 5th finger0.2377Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)