SUPERFAMILY 1.75 HMM library and genome assignments server

Cystine-knot cytokines superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Cystine-knot cytokines [ 57500]
Superfamily:   Cystine-knot cytokines [ 57501] (7)
Families:   Platelet-derived growth factor-like [ 57502] (3)
  Transforming growth factor (TGF)-beta [ 57507] (7)
  Noggin [ 82904]
  Neurotrophin [ 57520] (4)
  Gonadodropin/Follitropin [ 57528] (3)
  Interleukin 17F, IL-17F [ 69955]
  Coagulogen [ 57531]


Superfamily statistics
Genomes (139) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 6,152 14,377 40
Proteins 6,123 14,339 40


Functional annotation
General category Processes_IC
Detailed category Cell cycle, Apoptosis

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus0.000000000023230Least InformativeDirect
Biological Process (BP)developmental process0.00000000029890Least InformativeDirect
Biological Process (BP)multicellular organismal process0.0000000092940Least InformativeDirect
Biological Process (BP)single-organism cellular process0.000023650.000000000000001938Least InformativeDirect
Biological Process (BP)regulation of cellular process0.12950.00001925Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.32430.00001808Least InformativeInherited
Biological Process (BP)localization0.63870.000000009747Least InformativeInherited
Biological Process (BP)protein metabolic process0.088150.00000000913Least InformativeInherited
Biological Process (BP)reproduction0.000000025880Moderately InformativeDirect
Biological Process (BP)response to organic substance0.000000064750.0003127Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process0.0000081090Moderately InformativeDirect
Biological Process (BP)cell differentiation0.00021150Moderately InformativeDirect
Biological Process (BP)immune system process0.00054120Moderately InformativeDirect
Biological Process (BP)regulation of developmental process0.00080060Moderately InformativeDirect
Biological Process (BP)positive regulation of metabolic process0.00089490Moderately InformativeDirect
Biological Process (BP)regulation of localization10Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.038070Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.32370.0004861Moderately InformativeInherited
Biological Process (BP)tissue development0.07070.0000000000005632Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.14490.000000000001438Moderately InformativeInherited
Biological Process (BP)organ development0.011240.000000005258Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.55640Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process10Moderately InformativeInherited
Biological Process (BP)signal transduction0.12010Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.40560.04536Moderately InformativeInherited
Biological Process (BP)system process0.37620.7014Moderately InformativeInherited
Biological Process (BP)gene expression0.012181Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process10.0000000000008791Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.49140.1207Moderately InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process0.17580.001259Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.32581Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.871Moderately InformativeInherited
Biological Process (BP)nervous system development0.73780.9761Moderately InformativeInherited
Biological Process (BP)regulation of transcription from RNA polymerase II promoter0.00000000026550.0000000000006083InformativeDirect
Biological Process (BP)generation of neurons0.0000059760InformativeDirect
Biological Process (BP)regulation of protein phosphorylation0.0000099130.00000000000007357InformativeDirect
Biological Process (BP)blood circulation0.00001060.00000000000004447InformativeDirect
Biological Process (BP)response to wounding0.0000230InformativeDirect
Biological Process (BP)single organism reproductive process0.0001250.000000004262InformativeDirect
Biological Process (BP)regulation of hormone levels0.0001250.0001397InformativeDirect
Biological Process (BP)gland development0.00012770.00000009297InformativeDirect
Biological Process (BP)tube development0.0001490InformativeDirect
Biological Process (BP)positive regulation of developmental process0.00020930InformativeDirect
Biological Process (BP)growth0.00026360.00000001143InformativeDirect
Biological Process (BP)localization of cell0.00037950InformativeDirect
Biological Process (BP)locomotion0.00058370InformativeDirect
Biological Process (BP)regulation of cell proliferation0.00065120InformativeDirect
Biological Process (BP)enzyme linked receptor protein signaling pathway0.000740InformativeDirect
Biological Process (BP)regulation of anatomical structure morphogenesis0.0060250.0000000000006197InformativeInherited
Biological Process (BP)regulation of defense response0.0048561InformativeInherited
Biological Process (BP)regulation of response to external stimulus0.074060.000001505InformativeInherited
Biological Process (BP)regulation of cytokine production0.22860.06138InformativeInherited
Biological Process (BP)positive regulation of multicellular organismal process0.0042250InformativeInherited
Biological Process (BP)epithelium development0.63111InformativeInherited
Biological Process (BP)cardiovascular system development0.036950InformativeInherited
Biological Process (BP)muscle tissue development0.020140.2239InformativeInherited
Biological Process (BP)muscle structure development0.031880.05043InformativeInherited
Biological Process (BP)positive regulation of gene expression0.0065690InformativeInherited
Biological Process (BP)positive regulation of nucleobase-containing compound metabolic process0.018520.000000000000003755InformativeInherited
Biological Process (BP)positive regulation of macromolecule biosynthetic process0.019130.0000000000005501InformativeInherited
Biological Process (BP)positive regulation of cellular biosynthetic process0.030430.000000004542InformativeInherited
Biological Process (BP)multicellular organismal reproductive process0.14090.00005292InformativeInherited
Biological Process (BP)sensory organ development0.077770.001222InformativeInherited
Biological Process (BP)organ morphogenesis0.15540.000000001014InformativeInherited
Biological Process (BP)embryonic organ development0.014410.0000001257InformativeInherited
Biological Process (BP)regulation of cellular component movement0.17330InformativeInherited
Biological Process (BP)regulation of locomotion0.18710InformativeInherited
Biological Process (BP)hematopoietic or lymphoid organ development0.0074960InformativeInherited
Biological Process (BP)cellular component movement0.085390InformativeInherited
Biological Process (BP)regulation of body fluid levels0.0031120.0001718InformativeInherited
Biological Process (BP)regulation of cell development0.053670.1338InformativeInherited
Biological Process (BP)regulation of nervous system development0.057751InformativeInherited
Biological Process (BP)tissue morphogenesis0.032020.000000002597InformativeInherited
Biological Process (BP)reproductive system development0.000063270.04816InformativeInherited
Biological Process (BP)developmental process involved in reproduction0.004310.05599InformativeInherited
Biological Process (BP)anatomical structure formation involved in morphogenesis0.026560.00000000155InformativeInherited
Biological Process (BP)regulation of peptidyl-tyrosine phosphorylation0.0000000007730.0000000004597Highly InformativeDirect
Biological Process (BP)gonad development0.0000000076040.000000000001369Highly InformativeDirect
Biological Process (BP)ovulation cycle process0.0000000087720Highly InformativeDirect
Biological Process (BP)chemical homeostasis within a tissue0.0000000096420.000000000000007347Highly InformativeDirect
Biological Process (BP)protein processing0.000000023190.000363Highly InformativeDirect
Biological Process (BP)vascular process in circulatory system0.0000000330.0005847Highly InformativeDirect
Biological Process (BP)branching morphogenesis of an epithelial tube0.000000043950.0005948Highly InformativeDirect
Biological Process (BP)mammary gland alveolus development0.00000083560.00000008606Highly InformativeDirect
Biological Process (BP)cardiocyte differentiation0.0000039690.000000000000003755Highly InformativeDirect
Biological Process (BP)regulation of transmembrane receptor protein serine/threonine kinase signaling pathway0.000012610Highly InformativeDirect
Biological Process (BP)lactation0.000067460.00004362Highly InformativeDirect
Biological Process (BP)angiogenesis0.000070710Highly InformativeDirect
Biological Process (BP)renal system development0.00010630.0000000000004176Highly InformativeDirect
Biological Process (BP)positive regulation of transcription, DNA-dependent0.00011140Highly InformativeDirect
Biological Process (BP)positive regulation of cell migration0.00017130.0000000000005617Highly InformativeDirect
Biological Process (BP)heart morphogenesis0.00017890.00000000002601Highly InformativeDirect
Biological Process (BP)respiratory tube development0.00024830.0000000002201Highly InformativeDirect
Biological Process (BP)pattern specification process0.00030330.000000000008824Highly InformativeDirect
Biological Process (BP)regulation of cell adhesion0.00045210Highly InformativeDirect
Biological Process (BP)artery morphogenesis0.00081290.0006626Highly InformativeDirect
Biological Process (BP)positive regulation of cytokine production0.10041Highly InformativeInherited
Biological Process (BP)respiratory system development0.0011330.00005334Highly InformativeInherited
Biological Process (BP)erythrocyte differentiation0.14990.6658Highly InformativeInherited
Biological Process (BP)cardiac muscle tissue development0.00000012150.02963Highly InformativeInherited
Biological Process (BP)muscle fiber development0.00000016550.1788Highly InformativeInherited
Biological Process (BP)transmembrane receptor protein tyrosine kinase signaling pathway0.1741Highly InformativeInherited
Biological Process (BP)regulation of epithelial cell differentiation0.0024120.00006561Highly InformativeInherited
Biological Process (BP)eye morphogenesis0.00048371Highly InformativeInherited
Biological Process (BP)post-embryonic organ development0.0027811Highly InformativeInherited
Biological Process (BP)post-embryonic development0.084641Highly InformativeInherited
Biological Process (BP)regulation of neural precursor cell proliferation0.00047630.1183Highly InformativeInherited
Biological Process (BP)positive regulation of neurogenesis0.037340.2467Highly InformativeInherited
Biological Process (BP)positive regulation of epithelial cell proliferation0.0019760Highly InformativeInherited
Biological Process (BP)development of primary female sexual characteristics0.35180.0001057Highly InformativeInherited
Molecular Function (MF)binding0.00000021070Least InformativeDirect
Molecular Function (MF)anion binding0.021940.000007235Moderately InformativeInherited
Molecular Function (MF)receptor binding00InformativeDirect
Molecular Function (MF)sulfur compound binding0.000035820InformativeDirect
Molecular Function (MF)carbohydrate derivative binding0.000050250InformativeDirect
Molecular Function (MF)heparin binding0.000000096510Highly InformativeDirect
Molecular Function (MF)growth factor receptor binding0.16950.000002497Highly InformativeInherited
Molecular Function (MF)cytokine receptor binding0.84970.00000005256Highly InformativeInherited
Cellular Component (CC)extracellular region part0.0000000000000014340Moderately InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.000000000000001938 Least Informative Direct
Biological Process (BP) protein metabolic process 0.00000000913 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.00001925 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.00001808 Least Informative Direct
Biological Process (BP) localization 0.000000009747 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.000001502 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.2561 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.009261 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) reproduction 0 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.0003127 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0 Moderately Informative Direct
Biological Process (BP) cell differentiation 0 Moderately Informative Direct
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0 Moderately Informative Direct
Biological Process (BP) organ development 0.000000005258 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0 Moderately Informative Direct
Biological Process (BP) tissue development 0.0000000000005632 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.000000008837 Moderately Informative Direct
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.000000000001438 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.0004861 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 0 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 0.000000000000336 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.0000000000005661 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.0000000000008791 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 0.0000000003991 Moderately Informative Direct
Biological Process (BP) organic substance transport 0.00009574 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0.0001912 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.1207 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.1956 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.06763 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.07394 Moderately Informative Inherited
Biological Process (BP) system process 0.7014 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.001259 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.005983 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.0211 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.08381 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.9761 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.04536 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.1721 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.1093 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.3873 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.4366 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.8513 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.5211 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.3737 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.001525 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.0000000000006083 Informative Direct
Biological Process (BP) generation of neurons 0 Informative Direct
Biological Process (BP) regulation of protein phosphorylation 0.00000000000007357 Informative Direct
Biological Process (BP) blood circulation 0.00000000000004447 Informative Direct
Biological Process (BP) response to wounding 0 Informative Direct
Biological Process (BP) single organism reproductive process 0.000000004262 Informative Direct
Biological Process (BP) regulation of hormone levels 0.0001397 Informative Direct
Biological Process (BP) gland development 0.00000009297 Informative Direct
Biological Process (BP) tube development 0 Informative Direct
Biological Process (BP) positive regulation of developmental process 0 Informative Direct
Biological Process (BP) growth 0.00000001143 Informative Direct
Biological Process (BP) localization of cell 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) regulation of cell proliferation 0 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0 Informative Direct
Biological Process (BP) regulation of body fluid levels 0.0001718 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0 Informative Direct
Biological Process (BP) negative regulation of cell death 0.000000000108 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.0000000000006197 Informative Direct
Biological Process (BP) positive regulation of gene expression 0 Informative Direct
Biological Process (BP) hematopoietic or lymphoid organ development 0 Informative Direct
Biological Process (BP) embryonic organ development 0.0000001257 Informative Direct
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 0.000000000000003755 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.0000000000005501 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.00000000155 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0.000000004542 Informative Direct
Biological Process (BP) tissue morphogenesis 0.000000002597 Informative Direct
Biological Process (BP) cardiovascular system development 0 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0.000001505 Informative Direct
Biological Process (BP) cellular component movement 0 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 0.0000000001568 Informative Direct
Biological Process (BP) negative regulation of developmental process 0.00000000168 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 0 Informative Direct
Biological Process (BP) multicellular organismal reproductive process 0.00005292 Informative Direct
Biological Process (BP) organ morphogenesis 0.000000001014 Informative Direct
Biological Process (BP) regulation of cellular component movement 0 Informative Direct
Biological Process (BP) regulation of locomotion 0 Informative Direct
Biological Process (BP) regulation of growth 0.000000000000005594 Informative Direct
Biological Process (BP) positive regulation of protein metabolic process 0 Informative Direct
Biological Process (BP) positive regulation of signal transduction 0 Informative Direct
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.0000000000002825 Informative Direct
Biological Process (BP) positive regulation of transport 0.000000000004373 Informative Direct
Biological Process (BP) protein localization to organelle 0.000000000005834 Informative Direct
Biological Process (BP) apoptotic process 0.00000000002979 Informative Direct
Biological Process (BP) secretion by cell 0.000000005782 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.000001641 Informative Direct
Biological Process (BP) cell projection organization 0.00001334 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.00001646 Informative Direct
Biological Process (BP) glycosyl compound biosynthetic process 0.00002287 Informative Direct
Biological Process (BP) ribose phosphate biosynthetic process 0.00002447 Informative Direct
Biological Process (BP) response to nutrient levels 0.00002929 Informative Direct
Biological Process (BP) purine-containing compound biosynthetic process 0.00004204 Informative Direct
Biological Process (BP) regulation of secretion 0.0001256 Informative Direct
Biological Process (BP) lipid localization 0.0001493 Informative Direct
Biological Process (BP) cytoplasmic transport 0.0002811 Informative Direct
Biological Process (BP) cellular process involved in reproduction 0.0004421 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 0.0005563 Informative Direct
Biological Process (BP) regulation of apoptotic signaling pathway 0.01848 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.1928 Informative Inherited
Biological Process (BP) regulation of defense response 1 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.1207 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.03283 Informative Inherited
Biological Process (BP) response to lipid 0.006326 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.003941 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.3693 Informative Inherited
Biological Process (BP) response to bacterium 0.01468 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.002452 Informative Inherited
Biological Process (BP) regulation of protein localization 0.9389 Informative Inherited
Biological Process (BP) sensory organ development 0.001222 Informative Inherited
Biological Process (BP) muscle tissue development 0.2239 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.9171 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) muscle structure development 0.05043 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.02036 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.0801 Informative Inherited
Biological Process (BP) negative regulation of transport 0.00512 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.05599 Informative Inherited
Biological Process (BP) organic hydroxy compound biosynthetic process 0.08412 Informative Inherited
Biological Process (BP) purine ribonucleoside metabolic process 0.1212 Informative Inherited
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 0.02405 Informative Inherited
Biological Process (BP) regulation of kinase activity 1 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 1 Informative Inherited
Biological Process (BP) regulation of intracellular transport 1 Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.003928 Informative Inherited
Biological Process (BP) regulation of ion transport 1 Informative Inherited
Biological Process (BP) regulation of cell activation 0.004895 Informative Inherited
Biological Process (BP) regulation of system process 0.004461 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 0.1543 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.01545 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.0431 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.2188 Informative Inherited
Biological Process (BP) muscle system process 0.4804 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 1 Informative Inherited
Biological Process (BP) regulation of cell development 0.1338 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.9355 Informative Inherited
Biological Process (BP) nucleotide biosynthetic process 0.00163 Informative Inherited
Biological Process (BP) nucleoside triphosphate metabolic process 0.07007 Informative Inherited
Biological Process (BP) nucleoside monophosphate metabolic process 0.01397 Informative Inherited
Biological Process (BP) purine ribonucleotide metabolic process 0.1608 Informative Inherited
Biological Process (BP) single-organism behavior 0.07293 Informative Inherited
Biological Process (BP) multi-multicellular organism process 0.7148 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 1 Informative Inherited
Biological Process (BP) regulation of cell cycle process 1 Informative Inherited
Biological Process (BP) cell cycle process 0.1599 Informative Inherited
Biological Process (BP) protein transport 0.6287 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.5792 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.06138 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) regulation of immune effector process 1 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 0.003122 Informative Inherited
Biological Process (BP) reproductive system development 0.04816 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.9606 Informative Inherited
Biological Process (BP) regulation of peptidyl-tyrosine phosphorylation 0.0000000004597 Highly Informative Direct
Biological Process (BP) gonad development 0.000000000001369 Highly Informative Direct
Biological Process (BP) ovulation cycle process 0 Highly Informative Direct
Biological Process (BP) chemical homeostasis within a tissue 0.000000000000007347 Highly Informative Direct
Biological Process (BP) protein processing 0.000363 Highly Informative Direct
Biological Process (BP) vascular process in circulatory system 0.0005847 Highly Informative Direct
Biological Process (BP) branching morphogenesis of an epithelial tube 0.0005948 Highly Informative Direct
Biological Process (BP) mammary gland alveolus development 0.00000008606 Highly Informative Direct
Biological Process (BP) cardiocyte differentiation 0.000000000000003755 Highly Informative Direct
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0 Highly Informative Direct
Biological Process (BP) lactation 0.00004362 Highly Informative Direct
Biological Process (BP) angiogenesis 0 Highly Informative Direct
Biological Process (BP) renal system development 0.0000000000004176 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-dependent 0 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 0.0000000000005617 Highly Informative Direct
Biological Process (BP) heart morphogenesis 0.00000000002601 Highly Informative Direct
Biological Process (BP) respiratory tube development 0.0000000002201 Highly Informative Direct
Biological Process (BP) pattern specification process 0.000000000008824 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0 Highly Informative Direct
Biological Process (BP) artery morphogenesis 0.0006626 Highly Informative Direct
Biological Process (BP) respiratory system development 0.00005334 Highly Informative Direct
Biological Process (BP) positive regulation of epithelial cell proliferation 0 Highly Informative Direct
Biological Process (BP) regulation of epithelial cell differentiation 0.00006561 Highly Informative Direct
Biological Process (BP) mesenchyme development 0 Highly Informative Direct
Biological Process (BP) regulation of angiogenesis 0.0002599 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.00000001044 Highly Informative Direct
Biological Process (BP) regulation of organ morphogenesis 0.0000000000001131 Highly Informative Direct
Biological Process (BP) development of primary female sexual characteristics 0.0001057 Highly Informative Direct
Biological Process (BP) protein phosphorylation 0 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0 Highly Informative Direct
Biological Process (BP) protein localization to nucleus 0 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 0 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0 Highly Informative Direct
Biological Process (BP) ossification 0 Highly Informative Direct
Biological Process (BP) response to hypoxia 0 Highly Informative Direct
Biological Process (BP) skeletal system development 0 Highly Informative Direct
Biological Process (BP) negative regulation of cell cycle 0 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 0 Highly Informative Direct
Biological Process (BP) hair follicle development 0.000000000000007347 Highly Informative Direct
Biological Process (BP) hormone transport 0.00000000000002631 Highly Informative Direct
Biological Process (BP) chemotaxis 0.00000000000006071 Highly Informative Direct
Biological Process (BP) protein targeting to nucleus 0.0000000000001842 Highly Informative Direct
Biological Process (BP) negative regulation of cell growth 0.000000000001414 Highly Informative Direct
Biological Process (BP) regulation of behavior 0.000000000007921 Highly Informative Direct
Biological Process (BP) purine nucleoside triphosphate biosynthetic process 0.00000000001201 Highly Informative Direct
Biological Process (BP) ribonucleoside triphosphate biosynthetic process 0.00000000001944 Highly Informative Direct
Biological Process (BP) regulation of synaptic transmission 0.00000000002079 Highly Informative Direct
Biological Process (BP) regulation of MAP kinase activity 0.00000000002442 Highly Informative Direct
Biological Process (BP) nuclear import 0.0000000000294 Highly Informative Direct
Biological Process (BP) response to glucocorticoid stimulus 0.0000000002023 Highly Informative Direct
Biological Process (BP) stem cell development 0.0000000002201 Highly Informative Direct
Biological Process (BP) regulation of hormone secretion 0.0000000002406 Highly Informative Direct
Biological Process (BP) aminoglycan catabolic process 0.0000000007043 Highly Informative Direct
Biological Process (BP) protein import 0.000000002451 Highly Informative Direct
Biological Process (BP) mitotic cell cycle phase transition 0.000000005152 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate biosynthetic process 0.0000000106 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 0.00000001116 Highly Informative Direct
Biological Process (BP) positive regulation of response to external stimulus 0.00000001241 Highly Informative Direct
Biological Process (BP) regulation of production of molecular mediator of immune response 0.00000008386 Highly Informative Direct
Biological Process (BP) glycosaminoglycan metabolic process 0.000000101 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 0.0000005364 Highly Informative Direct
Biological Process (BP) negative regulation of lipid biosynthetic process 0.0000005851 Highly Informative Direct
Biological Process (BP) cell cycle phase 0.000001154 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0.000001165 Highly Informative Direct
Biological Process (BP) cell junction organization 0.000001273 Highly Informative Direct
Biological Process (BP) regulation of wound healing 0.000001821 Highly Informative Direct
Biological Process (BP) regulation of reproductive process 0.000002792 Highly Informative Direct
Biological Process (BP) regulation of reactive oxygen species metabolic process 0.000004943 Highly Informative Direct
Biological Process (BP) positive regulation of protein secretion 0.00000793 Highly Informative Direct
Biological Process (BP) female pregnancy 0.000008867 Highly Informative Direct
Biological Process (BP) modification of morphology or physiology of other organism involved in symbiotic interaction 0.000009768 Highly Informative Direct
Biological Process (BP) positive regulation of MAPK cascade 0.000009872 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 0.00001162 Highly Informative Direct
Biological Process (BP) regulation of cytokine biosynthetic process 0.00002128 Highly Informative Direct
Biological Process (BP) cell fate commitment 0.00003626 Highly Informative Direct
Biological Process (BP) connective tissue development 0.00004408 Highly Informative Direct
Biological Process (BP) negative regulation of mitotic cell cycle phase transition 0.00004524 Highly Informative Direct
Biological Process (BP) extrinsic apoptotic signaling pathway 0.00004619 Highly Informative Direct
Biological Process (BP) negative regulation of carbohydrate metabolic process 0.00004935 Highly Informative Direct
Biological Process (BP) regulation of mitosis 0.00007531 Highly Informative Direct
Biological Process (BP) nuclear export 0.0001483 Highly Informative Direct
Biological Process (BP) endocrine system development 0.0001898 Highly Informative Direct
Biological Process (BP) regulation of protein complex assembly 0.0001952 Highly Informative Direct
Biological Process (BP) interaction with host 0.0002311 Highly Informative Direct
Biological Process (BP) learning or memory 0.0003764 Highly Informative Direct
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.0004539 Highly Informative Direct
Biological Process (BP) regulation of mononuclear cell proliferation 0.0004586 Highly Informative Direct
Biological Process (BP) exocytosis 0.0007309 Highly Informative Direct
Biological Process (BP) negative regulation of neuron death 0.0007319 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 0.000874 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0.0009043 Highly Informative Direct
Biological Process (BP) positive regulation of apoptotic signaling pathway 0.005613 Highly Informative Inherited
Biological Process (BP) regulation of binding 0.02105 Highly Informative Inherited
Biological Process (BP) regulation of hemostasis 0.01359 Highly Informative Inherited
Biological Process (BP) positive regulation of ion transport 1 Highly Informative Inherited
Biological Process (BP) regulation of calcium ion transport 0.01748 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.6838 Highly Informative Inherited
Biological Process (BP) cellular response to steroid hormone stimulus 0.002134 Highly Informative Inherited
Biological Process (BP) response to alcohol 0.08869 Highly Informative Inherited
Biological Process (BP) response to lipopolysaccharide 0.01138 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic process 0.03415 Highly Informative Inherited
Biological Process (BP) regulation of nucleocytoplasmic transport 0.003302 Highly Informative Inherited
Biological Process (BP) regulation of protein localization to nucleus 0.07441 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.2706 Highly Informative Inherited
Biological Process (BP) erythrocyte differentiation 0.6658 Highly Informative Inherited
Biological Process (BP) regulation of striated muscle cell differentiation 0.002401 Highly Informative Inherited
Biological Process (BP) regulation of striated muscle tissue development 0.5179 Highly Informative Inherited
Biological Process (BP) regulation of protein kinase B signaling cascade 0.005094 Highly Informative Inherited
Biological Process (BP) regulation of amine transport 0.316 Highly Informative Inherited
Biological Process (BP) negative regulation of leukocyte activation 0.1325 Highly Informative Inherited
Biological Process (BP) cardiac muscle tissue development 0.02963 Highly Informative Inherited
Biological Process (BP) muscle fiber development 0.1788 Highly Informative Inherited
Biological Process (BP) negative regulation of secretion 0.0589 Highly Informative Inherited
Biological Process (BP) regulation of peptide transport 0.1275 Highly Informative Inherited
Biological Process (BP) regulation of myeloid cell differentiation 0.02971 Highly Informative Inherited
Biological Process (BP) positive regulation of lipid metabolic process 0.001082 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 1 Highly Informative Inherited
Biological Process (BP) hormone-mediated signaling pathway 0.7815 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 1 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 1 Highly Informative Inherited
Biological Process (BP) signal release 0.169 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.1957 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.7414 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.8971 Highly Informative Inherited
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 0.00152 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 1 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 1 Highly Informative Inherited
Biological Process (BP) post-embryonic development 1 Highly Informative Inherited
Biological Process (BP) wound healing 0.0441 Highly Informative Inherited
Biological Process (BP) coagulation 0.1195 Highly Informative Inherited
Biological Process (BP) hemostasis 1 Highly Informative Inherited
Biological Process (BP) multi-organism cellular process 0.01287 Highly Informative Inherited
Biological Process (BP) cell division 0.7285 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.3325 Highly Informative Inherited
Biological Process (BP) regulation of coagulation 0.02012 Highly Informative Inherited
Biological Process (BP) purine ribonucleoside triphosphate metabolic process 0.0501 Highly Informative Inherited
Biological Process (BP) purine ribonucleoside monophosphate metabolic process 0.009782 Highly Informative Inherited
Biological Process (BP) neuron projection development 1 Highly Informative Inherited
Biological Process (BP) cell part morphogenesis 1 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.4354 Highly Informative Inherited
Biological Process (BP) regulation of blood pressure 0.1778 Highly Informative Inherited
Biological Process (BP) negative regulation of immune effector process 0.03233 Highly Informative Inherited
Biological Process (BP) regulation of endocytosis 0.004805 Highly Informative Inherited
Biological Process (BP) regulation of neural precursor cell proliferation 0.1183 Highly Informative Inherited
Biological Process (BP) positive regulation of neurogenesis 0.2467 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) anion binding 0.000007235 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0.0008709 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) receptor binding 0 Informative Direct
Molecular Function (MF) sulfur compound binding 0 Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0 Informative Direct
Molecular Function (MF) protein dimerization activity 0.000000000001094 Informative Direct
Molecular Function (MF) enzyme activator activity 0.000000001626 Informative Direct
Molecular Function (MF) amide binding 0.04575 Informative Inherited
Molecular Function (MF) molecular transducer activity 0.9694 Informative Inherited
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1 Informative Inherited
Molecular Function (MF) heparin binding 0 Highly Informative Direct
Molecular Function (MF) growth factor receptor binding 0.000002497 Highly Informative Direct
Molecular Function (MF) cytokine receptor binding 0.00000005256 Highly Informative Direct
Molecular Function (MF) cytokine activity 0.000000006269 Highly Informative Direct
Molecular Function (MF) phosphatase regulator activity 0.000000000001883 Highly Informative Direct
Molecular Function (MF) protein homodimerization activity 0.000003814 Highly Informative Direct
Molecular Function (MF) peptide binding 0.0001985 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0.9585 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0.00000000000001332 Moderately Informative Direct
Cellular Component (CC) cell projection 0.0004683 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 0.4713 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) extracellular space 0 Informative Direct
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) extracellular matrix 0.0000000000001981 Informative Direct
Cellular Component (CC) secretory granule 0.000000000006198 Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.00000000005704 Highly Informative Direct
Cellular Component (CC) cell body 0.002342 Highly Informative Inherited

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.1554Least InformativeInherited
Disease Ontology (DO)immune system disease0.4665Least InformativeInherited
Disease Ontology (DO)nervous system disease0.4759Least InformativeInherited
Disease Ontology (DO)benign neoplasm0.00000009987Moderately InformativeDirect
Disease Ontology (DO)urinary system disease0.03075Moderately InformativeInherited
Disease Ontology (DO)endocrine system disease0.04417Moderately InformativeInherited
Disease Ontology (DO)sensory system disease0.06785Moderately InformativeInherited
Disease Ontology (DO)mouth disease0.07096Moderately InformativeInherited
Disease Ontology (DO)connective tissue disease0.2041Moderately InformativeInherited
Disease Ontology (DO)hematologic cancer0.246Moderately InformativeInherited
Disease Ontology (DO)obstructive lung disease0.4005Moderately InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.5735Moderately InformativeInherited
Disease Ontology (DO)prostate cancer0.00004638InformativeDirect
Disease Ontology (DO)glomerulonephritis0.0005016InformativeDirect
Disease Ontology (DO)arthropathy0.003755InformativeInherited
Disease Ontology (DO)myeloma0.004198InformativeInherited
Disease Ontology (DO)integumentary system cancer0.02363InformativeInherited
Disease Ontology (DO)auditory system disease0.0258InformativeInherited
Disease Ontology (DO)endocrine gland cancer0.0599InformativeInherited
Disease Ontology (DO)asthma0.109InformativeInherited
Disease Ontology (DO)organ system benign neoplasm0.2196InformativeInherited
Disease Ontology (DO)labyrinthine disease0.0001159Highly InformativeDirect
Disease Ontology (DO)rhabdomyosarcoma0.0002631Highly InformativeDirect
Disease Ontology (DO)aggressive systemic mastocytosis0.0007931Highly InformativeDirect
Disease Ontology (DO)skin carcinoma0.002994Highly InformativeInherited
Disease Ontology (DO)colonic disease0.01025Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Multifactorial inheritance0.00009676Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.02702Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of head and neck0.08119Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hand0.01115Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digit0.1169Moderately InformativeInherited
Phenotypic Abnormality (PA)Aplasia/hypoplasia involving the skeleton0.606Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.8858Moderately InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving bones of the feet0.03354InformativeInherited
Phenotypic Abnormality (PA)Abnormal facial shape0.2635InformativeInherited
Phenotypic Abnormality (PA)Abnormality of toe0.5318InformativeInherited
Phenotypic Abnormality (PA)Abnormality of phalanx of finger0.912InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia of the middle phalanges of the toes0.00001105Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the middle phalanges of the hand0.00006762Highly InformativeDirect
Phenotypic Abnormality (PA)Facial asymmetry0.0001888Highly InformativeDirect
Phenotypic Abnormality (PA)Broad toe0.001454Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hallux0.01635Highly InformativeInherited
Phenotypic Abnormality (PA)Absent toe0.05382Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the 5th finger0.2318Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

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