SUPERFAMILY 1.75 HMM library and genome assignments server


Cystine-knot cytokines superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Cystine-knot cytokines [ 57500]
Superfamily:   Cystine-knot cytokines [ 57501] (7)
Families:   Platelet-derived growth factor-like [ 57502] (3)
  Transforming growth factor (TGF)-beta [ 57507] (7)
  Noggin [ 82904]
  Neurotrophin [ 57520] (4)
  Gonadodropin/Follitropin [ 57528] (3)
  Interleukin 17F, IL-17F [ 69955]
  Coagulogen [ 57531]


Superfamily statistics
Genomes (139) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 6,152 14,377 40
Proteins 6,123 14,339 40


Functional annotation
General category Processes_IC
Detailed category Cell cycle, Apoptosis

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus2.153e-110Least InformativeDirect
Biological Process (BP)developmental process2.835e-100Least InformativeDirect
Biological Process (BP)multicellular organismal process8.969e-090Least InformativeDirect
Biological Process (BP)single-organism cellular process2.367e-051.931e-15Least InformativeDirect
Biological Process (BP)regulation of cellular process0.1262.16e-05Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.86190.0004078Least InformativeInherited
Biological Process (BP)localization0.63554.953e-09Least InformativeInherited
Biological Process (BP)protein metabolic process0.087455.916e-09Least InformativeInherited
Biological Process (BP)reproduction2.551e-080Moderately InformativeDirect
Biological Process (BP)response to organic substance5.932e-080.000272Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process6.72e-060Moderately InformativeDirect
Biological Process (BP)cell differentiation0.00021180Moderately InformativeDirect
Biological Process (BP)single-organism developmental process0.00038160Moderately InformativeDirect
Biological Process (BP)immune system process0.00054060Moderately InformativeDirect
Biological Process (BP)regulation of developmental process0.00070Moderately InformativeDirect
Biological Process (BP)regulation of localization10Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.32250.0005991Moderately InformativeInherited
Biological Process (BP)tissue development0.070718.605e-14Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.14222.303e-13Moderately InformativeInherited
Biological Process (BP)organ development0.010965.294e-09Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.034170Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.061410Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.03440.7823Moderately InformativeInherited
Biological Process (BP)signal transduction0.12590Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.40040.05566Moderately InformativeInherited
Biological Process (BP)system process0.37090.6862Moderately InformativeInherited
Biological Process (BP)gene expression0.012131Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process16.548e-13Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.090510.01498Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.24641Moderately InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process0.0077414.401e-05Moderately InformativeInherited
Biological Process (BP)nervous system development0.72860.9684Moderately InformativeInherited
Biological Process (BP)regulation of transcription from RNA polymerase II promoter2.231e-103.56e-13InformativeDirect
Biological Process (BP)generation of neurons5.929e-060InformativeDirect
Biological Process (BP)blood circulation1.064e-054.112e-14InformativeDirect
Biological Process (BP)response to wounding2.281e-050InformativeDirect
Biological Process (BP)positive regulation of gene expression0.00012350InformativeDirect
Biological Process (BP)single organism reproductive process0.00012473.684e-09InformativeDirect
Biological Process (BP)regulation of hormone levels0.00013350.0001115InformativeDirect
Biological Process (BP)gland development0.00013627.769e-08InformativeDirect
Biological Process (BP)tube development0.00015250InformativeDirect
Biological Process (BP)positive regulation of developmental process0.00021840InformativeDirect
Biological Process (BP)growth0.00025718.756e-09InformativeDirect
Biological Process (BP)localization of cell0.00038530InformativeDirect
Biological Process (BP)locomotion0.00059650InformativeDirect
Biological Process (BP)regulation of cell proliferation0.0006870InformativeDirect
Biological Process (BP)enzyme linked receptor protein signaling pathway0.00071630InformativeDirect
Biological Process (BP)positive regulation of macromolecule biosynthetic process0.00078663.741e-15InformativeDirect
Biological Process (BP)regulation of anatomical structure morphogenesis0.0056639.371e-13InformativeInherited
Biological Process (BP)regulation of defense response0.0047421InformativeInherited
Biological Process (BP)regulation of response to external stimulus0.075831.605e-06InformativeInherited
Biological Process (BP)regulation of cytokine production0.23930.05088InformativeInherited
Biological Process (BP)positive regulation of multicellular organismal process0.0042680InformativeInherited
Biological Process (BP)epithelium development0.63011InformativeInherited
Biological Process (BP)positive regulation of nitrogen compound metabolic process0.0011720InformativeInherited
Biological Process (BP)cardiovascular system development0.037470InformativeInherited
Biological Process (BP)muscle tissue development0.018680.2399InformativeInherited
Biological Process (BP)muscle structure development0.030660.04851InformativeInherited
Biological Process (BP)positive regulation of cellular biosynthetic process0.0013651.066e-10InformativeInherited
Biological Process (BP)multicellular organismal reproductive process0.14315.287e-05InformativeInherited
Biological Process (BP)sensory organ development0.074010.001189InformativeInherited
Biological Process (BP)organ morphogenesis0.151.917e-10InformativeInherited
Biological Process (BP)embryonic organ development0.014281.331e-07InformativeInherited
Biological Process (BP)regulation of cellular component movement0.1740InformativeInherited
Biological Process (BP)regulation of locomotion0.18750InformativeInherited
Biological Process (BP)hematopoietic or lymphoid organ development0.0074970InformativeInherited
Biological Process (BP)cellular component movement0.085280InformativeInherited
Biological Process (BP)regulation of body fluid levels0.0031620.0001806InformativeInherited
Biological Process (BP)regulation of cell development0.046630.2459InformativeInherited
Biological Process (BP)regulation of nervous system development0.061011InformativeInherited
Biological Process (BP)tissue morphogenesis0.032482.976e-09InformativeInherited
Biological Process (BP)reproductive system development6.511e-050.04834InformativeInherited
Biological Process (BP)developmental process involved in reproduction0.0043040.05238InformativeInherited
Biological Process (BP)anatomical structure formation involved in morphogenesis0.02581.164e-09InformativeInherited
Biological Process (BP)gonad development7.852e-091.411e-12Highly InformativeDirect
Biological Process (BP)chemical homeostasis within a tissue9.675e-091.931e-15Highly InformativeDirect
Biological Process (BP)ovulation cycle process1.097e-080Highly InformativeDirect
Biological Process (BP)protein processing2.051e-080.0003375Highly InformativeDirect
Biological Process (BP)vascular process in circulatory system3.313e-080.0005839Highly InformativeDirect
Biological Process (BP)branching morphogenesis of an epithelial tube4.416e-080.0006038Highly InformativeDirect
Biological Process (BP)mammary gland alveolus development8.462e-078.798e-08Highly InformativeDirect
Biological Process (BP)cardiocyte differentiation3.974e-063.741e-15Highly InformativeDirect
Biological Process (BP)regulation of transmembrane receptor protein serine/threonine kinase signaling pathway1.346e-050Highly InformativeDirect
Biological Process (BP)lactation6.739e-054.631e-05Highly InformativeDirect
Biological Process (BP)angiogenesis7.317e-050Highly InformativeDirect
Biological Process (BP)renal system development0.00010834.469e-13Highly InformativeDirect
Biological Process (BP)positive regulation of transcription, DNA-dependent0.00010870Highly InformativeDirect
Biological Process (BP)positive regulation of cell migration0.00016365.429e-13Highly InformativeDirect
Biological Process (BP)heart morphogenesis0.00018855.824e-11Highly InformativeDirect
Biological Process (BP)respiratory tube development0.00025242.328e-10Highly InformativeDirect
Biological Process (BP)pattern specification process0.00030839.848e-12Highly InformativeDirect
Biological Process (BP)regulation of cell adhesion0.00043620Highly InformativeDirect
Biological Process (BP)artery morphogenesis0.0008110.0006613Highly InformativeDirect
Biological Process (BP)positive regulation of cytokine production0.10191Highly InformativeInherited
Biological Process (BP)respiratory system development0.0011495.32e-05Highly InformativeInherited
Biological Process (BP)erythrocyte differentiation0.15530.6653Highly InformativeInherited
Biological Process (BP)cardiac muscle tissue development1.219e-070.03047Highly InformativeInherited
Biological Process (BP)muscle fiber development1.657e-070.1759Highly InformativeInherited
Biological Process (BP)transmembrane receptor protein tyrosine kinase signaling pathway0.17191Highly InformativeInherited
Biological Process (BP)eye morphogenesis0.0004141Highly InformativeInherited
Biological Process (BP)post-embryonic organ development0.0027211Highly InformativeInherited
Biological Process (BP)post-embryonic development0.084631Highly InformativeInherited
Biological Process (BP)regulation of neural precursor cell proliferation0.00048140.08583Highly InformativeInherited
Biological Process (BP)positive regulation of neurogenesis0.037930.2216Highly InformativeInherited
Biological Process (BP)positive regulation of epithelial cell proliferation0.0019990Highly InformativeInherited
Biological Process (BP)development of primary female sexual characteristics0.35180.0001083Highly InformativeInherited
Molecular Function (MF)binding2.035e-070Least InformativeDirect
Molecular Function (MF)anion binding0.021925.724e-06Moderately InformativeInherited
Molecular Function (MF)receptor binding00InformativeDirect
Molecular Function (MF)sulfur compound binding3.635e-050InformativeDirect
Molecular Function (MF)carbohydrate derivative binding5.105e-050InformativeDirect
Molecular Function (MF)heparin binding9.712e-080Highly InformativeDirect
Molecular Function (MF)growth factor receptor binding0.17412.796e-06Highly InformativeInherited
Molecular Function (MF)cytokine receptor binding0.85976.199e-08Highly InformativeInherited
Cellular Component (CC)extracellular region part1.454e-150Moderately InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 1.931e-15 Least Informative Direct
Biological Process (BP) protein metabolic process 5.916e-09 Least Informative Direct
Biological Process (BP) regulation of cellular process 2.16e-05 Least Informative Direct
Biological Process (BP) localization 4.953e-09 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.0004078 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 8.145e-07 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.2368 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.007611 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) reproduction 0 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.000272 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0 Moderately Informative Direct
Biological Process (BP) cell differentiation 0 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 0 Moderately Informative Direct
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 4.401e-05 Moderately Informative Direct
Biological Process (BP) organ development 5.294e-09 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0 Moderately Informative Direct
Biological Process (BP) tissue development 8.605e-14 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 6.212e-09 Moderately Informative Direct
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 2.303e-13 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.0005991 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 0 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 1.423e-13 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 6.548e-13 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 3.526e-12 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 8.269e-10 Moderately Informative Direct
Biological Process (BP) organic substance transport 0.0001108 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0.0001682 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.7823 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.01498 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.1927 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.06609 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.07209 Moderately Informative Inherited
Biological Process (BP) system process 0.6862 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.00227 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.01931 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.08834 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.9684 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.05566 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.148 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.1026 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.3347 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.3844 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.8403 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.5028 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.3769 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.001513 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.5667 Moderately Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 3.56e-13 Informative Direct
Biological Process (BP) generation of neurons 0 Informative Direct
Biological Process (BP) blood circulation 4.112e-14 Informative Direct
Biological Process (BP) response to wounding 0 Informative Direct
Biological Process (BP) positive regulation of gene expression 0 Informative Direct
Biological Process (BP) single organism reproductive process 3.684e-09 Informative Direct
Biological Process (BP) regulation of hormone levels 0.0001115 Informative Direct
Biological Process (BP) gland development 7.769e-08 Informative Direct
Biological Process (BP) tube development 0 Informative Direct
Biological Process (BP) positive regulation of developmental process 0 Informative Direct
Biological Process (BP) growth 8.756e-09 Informative Direct
Biological Process (BP) localization of cell 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) regulation of cell proliferation 0 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 3.741e-15 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 1.066e-10 Informative Direct
Biological Process (BP) regulation of body fluid levels 0.0001806 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0 Informative Direct
Biological Process (BP) negative regulation of cell death 7.531e-11 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 9.371e-13 Informative Direct
Biological Process (BP) hematopoietic or lymphoid organ development 0 Informative Direct
Biological Process (BP) embryonic organ development 1.331e-07 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 1.164e-09 Informative Direct
Biological Process (BP) tissue morphogenesis 2.976e-09 Informative Direct
Biological Process (BP) cardiovascular system development 0 Informative Direct
Biological Process (BP) regulation of response to external stimulus 1.605e-06 Informative Direct
Biological Process (BP) cellular component movement 0 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 1.334e-10 Informative Direct
Biological Process (BP) negative regulation of developmental process 1.033e-09 Informative Direct
Biological Process (BP) multicellular organismal reproductive process 5.287e-05 Informative Direct
Biological Process (BP) organ morphogenesis 1.917e-10 Informative Direct
Biological Process (BP) regulation of cellular component movement 0 Informative Direct
Biological Process (BP) regulation of locomotion 0 Informative Direct
Biological Process (BP) regulation of growth 3.741e-15 Informative Direct
Biological Process (BP) positive regulation of signal transduction 0 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 0 Informative Direct
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) positive regulation of protein modification process 0 Informative Direct
Biological Process (BP) regulation of establishment of protein localization 0 Informative Direct
Biological Process (BP) regulation of protein phosphorylation 7.738e-13 Informative Direct
Biological Process (BP) positive regulation of transport 2.259e-12 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 3.684e-12 Informative Direct
Biological Process (BP) protein localization to organelle 4.54e-12 Informative Direct
Biological Process (BP) apoptotic process 1.281e-10 Informative Direct
Biological Process (BP) secretion by cell 5.366e-09 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 1.279e-06 Informative Direct
Biological Process (BP) cell projection organization 1.329e-05 Informative Direct
Biological Process (BP) cellular component morphogenesis 1.757e-05 Informative Direct
Biological Process (BP) glycosyl compound biosynthetic process 2.19e-05 Informative Direct
Biological Process (BP) ribose phosphate biosynthetic process 2.28e-05 Informative Direct
Biological Process (BP) response to nutrient levels 2.349e-05 Informative Direct
Biological Process (BP) purine-containing compound biosynthetic process 3.928e-05 Informative Direct
Biological Process (BP) regulation of secretion 0.000139 Informative Direct
Biological Process (BP) lipid localization 0.0001531 Informative Direct
Biological Process (BP) cytoplasmic transport 0.0002515 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 0.000356 Informative Direct
Biological Process (BP) cellular process involved in reproduction 0.0004363 Informative Direct
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.1532 Informative Inherited
Biological Process (BP) regulation of defense response 1 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.1089 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.03423 Informative Inherited
Biological Process (BP) response to lipid 0.005596 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.004003 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.3563 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.002254 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.001448 Informative Inherited
Biological Process (BP) sensory organ development 0.001189 Informative Inherited
Biological Process (BP) muscle tissue development 0.2399 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.8996 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) muscle structure development 0.04851 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.02111 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.04664 Informative Inherited
Biological Process (BP) negative regulation of transport 0.004061 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.05238 Informative Inherited
Biological Process (BP) organic hydroxy compound biosynthetic process 0.08268 Informative Inherited
Biological Process (BP) purine ribonucleoside metabolic process 0.1165 Informative Inherited
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 0.0215 Informative Inherited
Biological Process (BP) regulation of kinase activity 1 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 1 Informative Inherited
Biological Process (BP) regulation of intracellular transport 1 Informative Inherited
Biological Process (BP) regulation of ion transport 1 Informative Inherited
Biological Process (BP) regulation of system process 0.002408 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 0.1481 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.01115 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.03537 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.1874 Informative Inherited
Biological Process (BP) response to other organism 0.09661 Informative Inherited
Biological Process (BP) muscle system process 0.4862 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 1 Informative Inherited
Biological Process (BP) regulation of cell development 0.2459 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.9228 Informative Inherited
Biological Process (BP) nucleotide biosynthetic process 0.001548 Informative Inherited
Biological Process (BP) nucleoside triphosphate metabolic process 0.0669 Informative Inherited
Biological Process (BP) nucleoside monophosphate metabolic process 0.01427 Informative Inherited
Biological Process (BP) purine ribonucleotide metabolic process 0.1544 Informative Inherited
Biological Process (BP) single-organism behavior 0.06731 Informative Inherited
Biological Process (BP) multi-multicellular organism process 0.7143 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 1 Informative Inherited
Biological Process (BP) regulation of cell cycle process 1 Informative Inherited
Biological Process (BP) cell cycle process 0.1617 Informative Inherited
Biological Process (BP) protein transport 0.6311 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.05088 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.8901 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 0.002588 Informative Inherited
Biological Process (BP) reproductive system development 0.04834 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.9598 Informative Inherited
Biological Process (BP) gonad development 1.411e-12 Highly Informative Direct
Biological Process (BP) chemical homeostasis within a tissue 1.931e-15 Highly Informative Direct
Biological Process (BP) ovulation cycle process 0 Highly Informative Direct
Biological Process (BP) protein processing 0.0003375 Highly Informative Direct
Biological Process (BP) vascular process in circulatory system 0.0005839 Highly Informative Direct
Biological Process (BP) branching morphogenesis of an epithelial tube 0.0006038 Highly Informative Direct
Biological Process (BP) mammary gland alveolus development 8.798e-08 Highly Informative Direct
Biological Process (BP) cardiocyte differentiation 3.741e-15 Highly Informative Direct
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0 Highly Informative Direct
Biological Process (BP) lactation 4.631e-05 Highly Informative Direct
Biological Process (BP) angiogenesis 0 Highly Informative Direct
Biological Process (BP) renal system development 4.469e-13 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-dependent 0 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 5.429e-13 Highly Informative Direct
Biological Process (BP) heart morphogenesis 5.824e-11 Highly Informative Direct
Biological Process (BP) respiratory tube development 2.328e-10 Highly Informative Direct
Biological Process (BP) pattern specification process 9.848e-12 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0 Highly Informative Direct
Biological Process (BP) artery morphogenesis 0.0006613 Highly Informative Direct
Biological Process (BP) respiratory system development 5.32e-05 Highly Informative Direct
Biological Process (BP) positive regulation of epithelial cell proliferation 0 Highly Informative Direct
Biological Process (BP) mesenchyme development 0 Highly Informative Direct
Biological Process (BP) regulation of angiogenesis 0.0001906 Highly Informative Direct
Biological Process (BP) developmental maturation 8.444e-07 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 5.584e-09 Highly Informative Direct
Biological Process (BP) regulation of organ morphogenesis 5.088e-14 Highly Informative Direct
Biological Process (BP) development of primary female sexual characteristics 0.0001083 Highly Informative Direct
Biological Process (BP) protein phosphorylation 0 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0 Highly Informative Direct
Biological Process (BP) protein localization to nucleus 0 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 0 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0 Highly Informative Direct
Biological Process (BP) ossification 0 Highly Informative Direct
Biological Process (BP) response to hypoxia 0 Highly Informative Direct
Biological Process (BP) skeletal system development 0 Highly Informative Direct
Biological Process (BP) negative regulation of cell cycle 0 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 0 Highly Informative Direct
Biological Process (BP) hair follicle development 0 Highly Informative Direct
Biological Process (BP) hormone transport 2.447e-14 Highly Informative Direct
Biological Process (BP) chemotaxis 8.605e-14 Highly Informative Direct
Biological Process (BP) protein targeting to nucleus 1.576e-13 Highly Informative Direct
Biological Process (BP) negative regulation of cell growth 1.475e-12 Highly Informative Direct
Biological Process (BP) purine ribonucleoside triphosphate biosynthetic process 6.272e-12 Highly Informative Direct
Biological Process (BP) regulation of behavior 6.405e-12 Highly Informative Direct
Biological Process (BP) regulation of synaptic transmission 1.17e-11 Highly Informative Direct
Biological Process (BP) regulation of MAP kinase activity 2.316e-11 Highly Informative Direct
Biological Process (BP) nuclear import 2.81e-11 Highly Informative Direct
Biological Process (BP) response to glucocorticoid stimulus 1.831e-10 Highly Informative Direct
Biological Process (BP) stem cell development 2.365e-10 Highly Informative Direct
Biological Process (BP) aminoglycan catabolic process 6.039e-10 Highly Informative Direct
Biological Process (BP) regulation of hormone secretion 6.119e-10 Highly Informative Direct
Biological Process (BP) protein import 2.395e-09 Highly Informative Direct
Biological Process (BP) mitotic cell cycle phase transition 4.82e-09 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 9.113e-09 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate biosynthetic process 1.048e-08 Highly Informative Direct
Biological Process (BP) positive regulation of response to external stimulus 1.442e-08 Highly Informative Direct
Biological Process (BP) regulation of production of molecular mediator of immune response 6.914e-08 Highly Informative Direct
Biological Process (BP) glycosaminoglycan metabolic process 7.553e-08 Highly Informative Direct
Biological Process (BP) negative regulation of cell activation 2.631e-07 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 2.631e-07 Highly Informative Direct
Biological Process (BP) negative regulation of lipid biosynthetic process 6.201e-07 Highly Informative Direct
Biological Process (BP) cell cycle phase 1.144e-06 Highly Informative Direct
Biological Process (BP) cell junction organization 1.453e-06 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 1.508e-06 Highly Informative Direct
Biological Process (BP) regulation of wound healing 2.027e-06 Highly Informative Direct
Biological Process (BP) purine ribonucleotide biosynthetic process 2.086e-06 Highly Informative Direct
Biological Process (BP) regulation of reactive oxygen species metabolic process 2.534e-06 Highly Informative Direct
Biological Process (BP) positive regulation of protein secretion 6.96e-06 Highly Informative Direct
Biological Process (BP) regulation of reproductive process 7.601e-06 Highly Informative Direct
Biological Process (BP) female pregnancy 8.049e-06 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 1.02e-05 Highly Informative Direct
Biological Process (BP) positive regulation of MAPK cascade 1.357e-05 Highly Informative Direct
Biological Process (BP) regulation of cytokine biosynthetic process 1.423e-05 Highly Informative Direct
Biological Process (BP) negative regulation of mitotic cell cycle phase transition 4.281e-05 Highly Informative Direct
Biological Process (BP) cell fate commitment 4.497e-05 Highly Informative Direct
Biological Process (BP) extrinsic apoptotic signaling pathway 4.665e-05 Highly Informative Direct
Biological Process (BP) negative regulation of carbohydrate metabolic process 5.014e-05 Highly Informative Direct
Biological Process (BP) connective tissue development 5.28e-05 Highly Informative Direct
Biological Process (BP) regulation of mitosis 7.398e-05 Highly Informative Direct
Biological Process (BP) regulation of protein complex assembly 0.0001177 Highly Informative Direct
Biological Process (BP) nuclear export 0.0001537 Highly Informative Direct
Biological Process (BP) endocrine system development 0.0001793 Highly Informative Direct
Biological Process (BP) learning or memory 0.0003058 Highly Informative Direct
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.0003431 Highly Informative Direct
Biological Process (BP) regulation of mononuclear cell proliferation 0.0004337 Highly Informative Direct
Biological Process (BP) exocytosis 0.0006938 Highly Informative Direct
Biological Process (BP) negative regulation of neuron death 0.0007427 Highly Informative Direct
Biological Process (BP) positive regulation of lipid metabolic process 0.0007556 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0.0008058 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 0.0008961 Highly Informative Direct
Biological Process (BP) positive regulation of apoptotic signaling pathway 0.005135 Highly Informative Inherited
Biological Process (BP) regulation of binding 0.01916 Highly Informative Inherited
Biological Process (BP) positive regulation of peptidyl-tyrosine phosphorylation 0.001578 Highly Informative Inherited
Biological Process (BP) regulation of hemostasis 0.01293 Highly Informative Inherited
Biological Process (BP) positive regulation of ion transport 1 Highly Informative Inherited
Biological Process (BP) regulation of calcium ion transport 0.01818 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.6495 Highly Informative Inherited
Biological Process (BP) cellular response to steroid hormone stimulus 0.002216 Highly Informative Inherited
Biological Process (BP) response to alcohol 0.087 Highly Informative Inherited
Biological Process (BP) response to lipopolysaccharide 0.01162 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic process 0.03477 Highly Informative Inherited
Biological Process (BP) regulation of nucleocytoplasmic transport 0.003621 Highly Informative Inherited
Biological Process (BP) regulation of protein localization to nucleus 0.07397 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.2719 Highly Informative Inherited
Biological Process (BP) erythrocyte differentiation 0.6653 Highly Informative Inherited
Biological Process (BP) regulation of striated muscle tissue development 0.5419 Highly Informative Inherited
Biological Process (BP) regulation of protein kinase B signaling cascade 0.004725 Highly Informative Inherited
Biological Process (BP) regulation of amine transport 0.3178 Highly Informative Inherited
Biological Process (BP) cardiac muscle tissue development 0.03047 Highly Informative Inherited
Biological Process (BP) muscle fiber development 0.1759 Highly Informative Inherited
Biological Process (BP) negative regulation of secretion 0.05521 Highly Informative Inherited
Biological Process (BP) regulation of peptide transport 0.1706 Highly Informative Inherited
Biological Process (BP) regulation of myeloid cell differentiation 0.02501 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 0.854 Highly Informative Inherited
Biological Process (BP) hormone-mediated signaling pathway 0.7717 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 1 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.003248 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 1 Highly Informative Inherited
Biological Process (BP) signal release 0.1598 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.1839 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.7375 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.8755 Highly Informative Inherited
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 0.001296 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 1 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 1 Highly Informative Inherited
Biological Process (BP) post-embryonic development 1 Highly Informative Inherited
Biological Process (BP) wound healing 0.04207 Highly Informative Inherited
Biological Process (BP) coagulation 0.1207 Highly Informative Inherited
Biological Process (BP) hemostasis 1 Highly Informative Inherited
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.005516 Highly Informative Inherited
Biological Process (BP) modification of morphology or physiology of other organism 0.01603 Highly Informative Inherited
Biological Process (BP) multi-organism cellular process 0.0128 Highly Informative Inherited
Biological Process (BP) cell division 0.7316 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.2373 Highly Informative Inherited
Biological Process (BP) regulation of coagulation 0.01917 Highly Informative Inherited
Biological Process (BP) neuron projection development 1 Highly Informative Inherited
Biological Process (BP) cell part morphogenesis 1 Highly Informative Inherited
Biological Process (BP) ATP metabolic process 0.005718 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.4278 Highly Informative Inherited
Biological Process (BP) regulation of blood pressure 0.171 Highly Informative Inherited
Biological Process (BP) regulation of endocytosis 0.003545 Highly Informative Inherited
Biological Process (BP) regulation of neural precursor cell proliferation 0.08583 Highly Informative Inherited
Biological Process (BP) positive regulation of neurogenesis 0.2216 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) anion binding 5.724e-06 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0.0008624 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) receptor binding 0 Informative Direct
Molecular Function (MF) sulfur compound binding 0 Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0 Informative Direct
Molecular Function (MF) protein dimerization activity 1.185e-12 Informative Direct
Molecular Function (MF) enzyme activator activity 1.369e-09 Informative Direct
Molecular Function (MF) amide binding 0.044 Informative Inherited
Molecular Function (MF) molecular transducer activity 0.9691 Informative Inherited
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1 Informative Inherited
Molecular Function (MF) heparin binding 0 Highly Informative Direct
Molecular Function (MF) growth factor receptor binding 2.796e-06 Highly Informative Direct
Molecular Function (MF) cytokine receptor binding 6.199e-08 Highly Informative Direct
Molecular Function (MF) phosphatase regulator activity 1.553e-12 Highly Informative Direct
Molecular Function (MF) cytokine activity 8.092e-09 Highly Informative Direct
Molecular Function (MF) protein homodimerization activity 1.797e-06 Highly Informative Direct
Molecular Function (MF) peptide binding 0.0001735 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0.9561 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) vesicle 8.985e-15 Moderately Informative Direct
Cellular Component (CC) cell projection 0.0003475 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 0.4582 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) extracellular space 0 Informative Direct
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) extracellular matrix 1.669e-13 Informative Direct
Cellular Component (CC) secretory granule 5.529e-12 Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 4.325e-11 Highly Informative Direct
Cellular Component (CC) cell body 0.002184 Highly Informative Inherited

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.1498Least InformativeInherited
Disease Ontology (DO)immune system disease0.4558Least InformativeInherited
Disease Ontology (DO)nervous system disease0.5425Least InformativeInherited
Disease Ontology (DO)benign neoplasm8.907e-08Moderately InformativeDirect
Disease Ontology (DO)lung disease0.0001296Moderately InformativeDirect
Disease Ontology (DO)musculoskeletal system cancer0.00828Moderately InformativeInherited
Disease Ontology (DO)urinary system disease0.02955Moderately InformativeInherited
Disease Ontology (DO)endocrine system disease0.04323Moderately InformativeInherited
Disease Ontology (DO)mouth disease0.071Moderately InformativeInherited
Disease Ontology (DO)sensory system disease0.1231Moderately InformativeInherited
Disease Ontology (DO)connective tissue disease0.2028Moderately InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.5744Moderately InformativeInherited
Disease Ontology (DO)prostate cancer4.638e-05InformativeDirect
Disease Ontology (DO)glomerulonephritis0.0005018InformativeDirect
Disease Ontology (DO)arthropathy0.003811InformativeInherited
Disease Ontology (DO)myeloma0.00428InformativeInherited
Disease Ontology (DO)auditory system disease0.01428InformativeInherited
Disease Ontology (DO)integumentary system cancer0.02368InformativeInherited
Disease Ontology (DO)endocrine gland cancer0.05618InformativeInherited
Disease Ontology (DO)asthma0.1081InformativeInherited
Disease Ontology (DO)organ system benign neoplasm0.2175InformativeInherited
Disease Ontology (DO)labyrinthine disease0.0001165Highly InformativeDirect
Disease Ontology (DO)rhabdomyosarcoma0.0002633Highly InformativeDirect
Disease Ontology (DO)aggressive systemic mastocytosis0.0007956Highly InformativeDirect
Disease Ontology (DO)skin carcinoma0.002997Highly InformativeInherited
Disease Ontology (DO)colonic disease0.0103Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Multifactorial inheritance9.823e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.02708Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of head and neck0.08122Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hand0.01119Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digit0.117Moderately InformativeInherited
Phenotypic Abnormality (PA)Aplasia/hypoplasia involving the skeleton0.6062Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.8861Moderately InformativeInherited
Phenotypic Abnormality (PA)Aplasia/hypoplasia involving bones of the lower limbs0.06616InformativeInherited