SUPERFAMILY 1.75 HMM library and genome assignments server


Cystine-knot cytokines superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Cystine-knot cytokines [ 57500]
Superfamily:   Cystine-knot cytokines [ 57501] (7)
Families:   Platelet-derived growth factor-like [ 57502] (3)
  Transforming growth factor (TGF)-beta [ 57507] (7)
  Noggin [ 82904]
  Neurotrophin [ 57520] (4)
  Gonadodropin/Follitropin [ 57528] (3)
  Interleukin 17F, IL-17F [ 69955]
  Coagulogen [ 57531]


Superfamily statistics
Genomes (127) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 5,617 12,221 40
Proteins 5,593 12,194 40


Functional annotation
General category Processes_IC
Detailed category Cell cycle, Apoptosis

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus3.137e-100Least InformativeDirect
Biological Process (BP)developmental process5.8e-100Least InformativeDirect
Biological Process (BP)multicellular organismal process2.381e-090Least InformativeDirect
Biological Process (BP)single-organism cellular process1.137e-053.746e-15Least InformativeDirect
Biological Process (BP)regulation of cellular process0.17973.588e-05Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.98320.0003645Least InformativeInherited
Biological Process (BP)localization0.49692.613e-09Least InformativeInherited
Biological Process (BP)protein metabolic process0.055873.169e-09Least InformativeInherited
Biological Process (BP)reproduction4.596e-090Moderately InformativeDirect
Biological Process (BP)response to organic substance7.232e-070.0008253Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process8.657e-060Moderately InformativeDirect
Biological Process (BP)cell differentiation6.895e-050Moderately InformativeDirect
Biological Process (BP)immune system process0.00016760Moderately InformativeDirect
Biological Process (BP)regulation of developmental process0.00040670Moderately InformativeDirect
Biological Process (BP)single-organism developmental process0.00047820Moderately InformativeDirect
Biological Process (BP)regulation of localization10Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.33280.00012Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.043692.453e-07Moderately InformativeInherited
Biological Process (BP)tissue development0.04721.605e-14Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.14679.23e-14Moderately InformativeInherited
Biological Process (BP)organ development0.0033643.126e-09Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.03450Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.08170Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.074220.7543Moderately InformativeInherited
Biological Process (BP)signal transduction0.1940Moderately InformativeInherited
Biological Process (BP)system process0.3080.6422Moderately InformativeInherited
Biological Process (BP)homeostatic process0.6141Moderately InformativeInherited
Biological Process (BP)gene expression0.0069981Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.1720.01458Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.37161Moderately InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process0.022655.219e-05Moderately InformativeInherited
Biological Process (BP)nervous system development0.73460.9369Moderately InformativeInherited
Biological Process (BP)regulation of transcription from RNA polymerase II promoter2.49e-081.67e-13InformativeDirect
Biological Process (BP)generation of neurons2.56e-060InformativeDirect
Biological Process (BP)blood circulation5.206e-061.948e-14InformativeDirect
Biological Process (BP)response to wounding1.418e-055.586e-15InformativeDirect
Biological Process (BP)growth1.51e-059.457e-11InformativeDirect
Biological Process (BP)positive regulation of gene expression4.85e-050InformativeDirect
Biological Process (BP)single organism reproductive process6.96e-052.133e-09InformativeDirect
Biological Process (BP)gland development0.00010581.435e-07InformativeDirect
Biological Process (BP)regulation of hormone levels0.00017980.0001872InformativeDirect
Biological Process (BP)positive regulation of developmental process0.00018770InformativeDirect
Biological Process (BP)localization of cell0.00025010InformativeDirect
Biological Process (BP)positive regulation of macromolecule biosynthetic process0.00052163.746e-15InformativeDirect
Biological Process (BP)positive regulation of cell proliferation0.00076820InformativeDirect
Biological Process (BP)positive regulation of cellular biosynthetic process0.00085557.679e-11InformativeDirect
Biological Process (BP)positive regulation of nitrogen compound metabolic process0.00095780InformativeDirect
Biological Process (BP)regulation of anatomical structure morphogenesis0.0077343.827e-13InformativeInherited
Biological Process (BP)regulation of defense response0.0028941InformativeInherited
Biological Process (BP)regulation of response to external stimulus0.073414.002e-06InformativeInherited
Biological Process (BP)regulation of cytokine production0.18330.03294InformativeInherited
Biological Process (BP)positive regulation of multicellular organismal process0.0020740InformativeInherited
Biological Process (BP)epithelium development0.63231InformativeInherited
Biological Process (BP)cardiovascular system development0.037650InformativeInherited
Biological Process (BP)muscle tissue development0.016350.2432InformativeInherited
Biological Process (BP)muscle structure development0.023230.03886InformativeInherited
Biological Process (BP)enzyme linked receptor protein signaling pathway0.002760InformativeInherited
Biological Process (BP)multicellular organismal reproductive process0.14772.368e-05InformativeInherited
Biological Process (BP)sensory organ development0.061250.003025InformativeInherited
Biological Process (BP)organ morphogenesis0.11927.046e-11InformativeInherited
Biological Process (BP)embryonic organ development0.010559.489e-08InformativeInherited
Biological Process (BP)regulation of cellular component movement0.15760InformativeInherited
Biological Process (BP)regulation of locomotion0.17320InformativeInherited
Biological Process (BP)hematopoietic or lymphoid organ development0.0032760InformativeInherited
Biological Process (BP)locomotion0.0022150InformativeInherited
Biological Process (BP)cellular component movement0.075710InformativeInherited
Biological Process (BP)regulation of body fluid levels0.0026420.0002152InformativeInherited
Biological Process (BP)regulation of cell development0.046950.3892InformativeInherited
Biological Process (BP)regulation of nervous system development0.052151InformativeInherited
Biological Process (BP)tissue morphogenesis0.02391.301e-09InformativeInherited
Biological Process (BP)reproductive structure development1.824e-050.01224InformativeInherited
Biological Process (BP)anatomical structure formation involved in morphogenesis0.014898.918e-10InformativeInherited
Biological Process (BP)gonad development4.789e-094.177e-12Highly InformativeDirect
Biological Process (BP)ovulation cycle process9.682e-090Highly InformativeDirect
Biological Process (BP)positive regulation of transcription, DNA-dependent1.002e-080Highly InformativeDirect
Biological Process (BP)protein processing1.016e-080.0003204Highly InformativeDirect
Biological Process (BP)vascular process in circulatory system1.839e-080.0008309Highly InformativeDirect
Biological Process (BP)morphogenesis of a branching epithelium4.34e-081.239e-07Highly InformativeDirect
Biological Process (BP)mammary gland alveolus development7.627e-071.256e-07Highly InformativeDirect
Biological Process (BP)tissue homeostasis1.202e-065.017e-07Highly InformativeDirect
Biological Process (BP)cardiocyte differentiation4.709e-067.333e-15Highly InformativeDirect
Biological Process (BP)angiogenesis5.411e-050Highly InformativeDirect
Biological Process (BP)lactation7.515e-055.832e-05Highly InformativeDirect
Biological Process (BP)renal system development0.00010844.677e-13Highly InformativeDirect
Biological Process (BP)positive regulation of cell migration0.00011819.377e-13Highly InformativeDirect
Biological Process (BP)heart morphogenesis0.00012583.027e-11Highly InformativeDirect
Biological Process (BP)lung development0.00017092.141e-10Highly InformativeDirect
Biological Process (BP)artery morphogenesis0.00089580.0006901Highly InformativeDirect
Biological Process (BP)cell proliferation0.00090748.676e-08Highly InformativeDirect
Biological Process (BP)positive regulation of cytokine production0.10161Highly InformativeInherited
Biological Process (BP)regulation of inflammatory response0.0001971Highly InformativeInherited
Biological Process (BP)erythrocyte differentiation0.13120.6714Highly InformativeInherited
Biological Process (BP)cardiac muscle tissue development8.41e-080.03368Highly InformativeInherited
Biological Process (BP)muscle fiber development9.853e-080.1892Highly InformativeInherited
Biological Process (BP)transmembrane receptor protein tyrosine kinase signaling pathway0.26041Highly InformativeInherited
Biological Process (BP)photoreceptor cell differentiation5.035e-080.1061Highly InformativeInherited
Biological Process (BP)eye morphogenesis0.00041771Highly InformativeInherited
Biological Process (BP)post-embryonic organ development0.0019521Highly InformativeInherited
Biological Process (BP)post-embryonic development0.062341Highly InformativeInherited
Biological Process (BP)regulation of neural precursor cell proliferation0.00012580.03812Highly InformativeInherited
Biological Process (BP)positive regulation of cell differentiation0.0070910Highly InformativeInherited
Biological Process (BP)positive regulation of epithelial cell proliferation0.0028530Highly InformativeInherited
Biological Process (BP)development of primary female sexual characteristics0.37280.0001049Highly InformativeInherited
Molecular Function (MF)binding1.555e-070Least InformativeDirect
Molecular Function (MF)anion binding0.013483.184e-06Moderately InformativeInherited
Molecular Function (MF)receptor binding00InformativeDirect
Molecular Function (MF)sulfur compound binding2.7e-050InformativeDirect
Molecular Function (MF)carbohydrate derivative binding3.659e-050InformativeDirect
Molecular Function (MF)heparin binding5.827e-080Highly InformativeDirect
Molecular Function (MF)growth factor receptor binding0.1528.159e-06Highly InformativeInherited
Molecular Function (MF)cytokine receptor binding0.81789.622e-08Highly InformativeInherited
Cellular Component (CC)extracellular region part2.006e-130Moderately InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 3.746e-15 Least Informative Direct
Biological Process (BP) protein metabolic process 3.169e-09 Least Informative Direct
Biological Process (BP) regulation of cellular process 3.588e-05 Least Informative Direct
Biological Process (BP) localization 2.613e-09 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 2.649e-07 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.0003645 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.1966 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.005872 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) reproduction 0 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.0008253 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0 Moderately Informative Direct
Biological Process (BP) cell differentiation 0 Moderately Informative Direct
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 0 Moderately Informative Direct
Biological Process (BP) organ development 3.126e-09 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 1.931e-15 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 5.219e-05 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 2.453e-07 Moderately Informative Direct
Biological Process (BP) tissue development 1.605e-14 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 9.23e-14 Moderately Informative Direct
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.00012 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 0 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 2.143e-13 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 6.324e-13 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 1.789e-12 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 2.098e-12 Moderately Informative Direct
Biological Process (BP) organic substance transport 0.000119 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0.0001282 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.7543 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.01458 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.1886 Moderately Informative Inherited
Biological Process (BP) regulation of programmed cell death 0.2577 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.05559 Moderately Informative Inherited
Biological Process (BP) system process 0.6422 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.002215 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.01651 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.07236 Moderately Informative Inherited
Biological Process (BP) macromolecule catabolic process 0.6926 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.02558 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.9369 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.09677 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.08642 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.3239 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.3715 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.8049 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.4728 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.3545 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.002178 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.5525 Moderately Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 1.67e-13 Informative Direct
Biological Process (BP) generation of neurons 0 Informative Direct
Biological Process (BP) blood circulation 1.948e-14 Informative Direct
Biological Process (BP) response to wounding 5.586e-15 Informative Direct
Biological Process (BP) growth 9.457e-11 Informative Direct
Biological Process (BP) positive regulation of gene expression 0 Informative Direct
Biological Process (BP) single organism reproductive process 2.133e-09 Informative Direct
Biological Process (BP) gland development 1.435e-07 Informative Direct
Biological Process (BP) regulation of hormone levels 0.0001872 Informative Direct
Biological Process (BP) positive regulation of developmental process 0 Informative Direct
Biological Process (BP) localization of cell 0 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 3.746e-15 Informative Direct
Biological Process (BP) positive regulation of cell proliferation 0 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 7.679e-11 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0 Informative Direct
Biological Process (BP) cell-cell signaling 3.329e-08 Informative Direct
Biological Process (BP) negative regulation of cell death 9.371e-10 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) regulation of body fluid levels 0.0002152 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0 Informative Direct
Biological Process (BP) hematopoietic or lymphoid organ development 0 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 3.827e-13 Informative Direct
Biological Process (BP) embryonic organ development 9.489e-08 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 5.904e-10 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 8.918e-10 Informative Direct
Biological Process (BP) tissue morphogenesis 1.301e-09 Informative Direct
Biological Process (BP) cardiovascular system development 0 Informative Direct
Biological Process (BP) regulation of response to external stimulus 4.002e-06 Informative Direct
Biological Process (BP) cellular component movement 0 Informative Direct
Biological Process (BP) negative regulation of developmental process 4.857e-09 Informative Direct
Biological Process (BP) organ morphogenesis 7.046e-11 Informative Direct
Biological Process (BP) regulation of growth 5.586e-15 Informative Direct
Biological Process (BP) multicellular organismal reproductive process 2.368e-05 Informative Direct
Biological Process (BP) regulation of cellular component movement 0 Informative Direct
Biological Process (BP) regulation of locomotion 0 Informative Direct
Biological Process (BP) positive regulation of signal transduction 0 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 0 Informative Direct
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) positive regulation of protein metabolic process 0 Informative Direct
Biological Process (BP) regulation of establishment of protein localization 0 Informative Direct
Biological Process (BP) regulation of protein phosphorylation 8.766e-13 Informative Direct
Biological Process (BP) positive regulation of transport 1.858e-12 Informative Direct
Biological Process (BP) protein localization to organelle 4.195e-12 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 6.166e-12 Informative Direct
Biological Process (BP) regulation of cell cycle 2.862e-09 Informative Direct
Biological Process (BP) secretion by cell 4.962e-09 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 3.402e-07 Informative Direct
Biological Process (BP) response to nutrient levels 1.32e-05 Informative Direct
Biological Process (BP) ribose phosphate biosynthetic process 1.544e-05 Informative Direct
Biological Process (BP) cell projection organization 1.593e-05 Informative Direct
Biological Process (BP) glycosyl compound biosynthetic process 1.657e-05 Informative Direct
Biological Process (BP) purine-containing compound biosynthetic process 2.772e-05 Informative Direct
Biological Process (BP) cellular component morphogenesis 2.978e-05 Informative Direct
Biological Process (BP) regulation of secretion 9.052e-05 Informative Direct
Biological Process (BP) lipid localization 0.0001654 Informative Direct
Biological Process (BP) cytoplasmic transport 0.0002192 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 0.0002895 Informative Direct
Biological Process (BP) cellular process involved in reproduction 0.0004426 Informative Direct
Biological Process (BP) regulation of system process 0.0009988 Informative Direct
Biological Process (BP) regulation of apoptotic signaling pathway 0.02044 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.2501 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.1254 Informative Inherited
Biological Process (BP) regulation of defense response 1 Informative Inherited
Biological Process (BP) cell death 0.004564 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.105 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.02786 Informative Inherited
Biological Process (BP) response to lipid 0.00524 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.002284 Informative Inherited
Biological Process (BP) response to bacterium 0.04955 Informative Inherited
Biological Process (BP) muscle tissue development 0.2432 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.8219 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) muscle structure development 0.03886 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.03005 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.0366 Informative Inherited
Biological Process (BP) organic hydroxy compound biosynthetic process 0.08442 Informative Inherited
Biological Process (BP) purine ribonucleoside metabolic process 0.1023 Informative Inherited
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 0.02226 Informative Inherited
Biological Process (BP) protein complex assembly 0.03103 Informative Inherited
Biological Process (BP) regulation of kinase activity 1 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 1 Informative Inherited
Biological Process (BP) sensory organ development 0.003025 Informative Inherited
Biological Process (BP) regulation of intracellular transport 1 Informative Inherited
Biological Process (BP) regulation of ion transport 1 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.001424 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 0.1392 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.006758 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.02228 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.1252 Informative Inherited
Biological Process (BP) cell activation 0.2322 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 1 Informative Inherited
Biological Process (BP) regulation of cell development 0.3892 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.9209 Informative Inherited
Biological Process (BP) nucleotide biosynthetic process 0.001127 Informative Inherited
Biological Process (BP) nucleoside triphosphate metabolic process 0.0596 Informative Inherited
Biological Process (BP) nucleoside monophosphate metabolic process 0.01321 Informative Inherited
Biological Process (BP) purine ribonucleotide metabolic process 0.14 Informative Inherited
Biological Process (BP) cell cycle process 0.2 Informative Inherited
Biological Process (BP) protein transport 0.6263 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.03294 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.8772 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) reproductive structure development 0.01224 Informative Inherited
Biological Process (BP) gonad development 4.177e-12 Highly Informative Direct
Biological Process (BP) ovulation cycle process 0 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-dependent 0 Highly Informative Direct
Biological Process (BP) protein processing 0.0003204 Highly Informative Direct
Biological Process (BP) vascular process in circulatory system 0.0008309 Highly Informative Direct
Biological Process (BP) morphogenesis of a branching epithelium 1.239e-07 Highly Informative Direct
Biological Process (BP) mammary gland alveolus development 1.256e-07 Highly Informative Direct
Biological Process (BP) tissue homeostasis 5.017e-07 Highly Informative Direct
Biological Process (BP) cardiocyte differentiation 7.333e-15 Highly Informative Direct
Biological Process (BP) angiogenesis 0 Highly Informative Direct
Biological Process (BP) lactation 5.832e-05 Highly Informative Direct
Biological Process (BP) renal system development 4.677e-13 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 9.377e-13 Highly Informative Direct
Biological Process (BP) heart morphogenesis 3.027e-11 Highly Informative Direct
Biological Process (BP) lung development 2.141e-10 Highly Informative Direct
Biological Process (BP) artery morphogenesis 0.0006901 Highly Informative Direct
Biological Process (BP) cell proliferation 8.676e-08 Highly Informative Direct
Biological Process (BP) pattern specification process 1.187e-10 Highly Informative Direct
Biological Process (BP) mesenchyme development 0 Highly Informative Direct
Biological Process (BP) positive regulation of epithelial cell proliferation 0 Highly Informative Direct
Biological Process (BP) developmental maturation 1.218e-06 Highly Informative Direct
Biological Process (BP) regulation of angiogenesis 0.0007895 Highly Informative Direct
Biological Process (BP) positive regulation of cell differentiation 0 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 3.179e-09 Highly Informative Direct
Biological Process (BP) regulation of organ morphogenesis 1.086e-14 Highly Informative Direct
Biological Process (BP) development of primary female sexual characteristics 0.0001049 Highly Informative Direct
Biological Process (BP) protein phosphorylation 0 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0 Highly Informative Direct
Biological Process (BP) protein localization to nucleus 0 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 0 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0 Highly Informative Direct
Biological Process (BP) ossification 0 Highly Informative Direct
Biological Process (BP) response to hypoxia 0 Highly Informative Direct
Biological Process (BP) skeletal system development 0 Highly Informative Direct
Biological Process (BP) negative regulation of cell cycle 0 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 0 Highly Informative Direct
Biological Process (BP) hair follicle development 0 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0 Highly Informative Direct
Biological Process (BP) hormone transport 1.773e-14 Highly Informative Direct
Biological Process (BP) chemotaxis 5.243e-14 Highly Informative Direct
Biological Process (BP) protein targeting to nucleus 1.914e-13 Highly Informative Direct
Biological Process (BP) regulation of cell growth 2.548e-13 Highly Informative Direct
Biological Process (BP) negative regulation of growth 1.341e-12 Highly Informative Direct
Biological Process (BP) regulation of synaptic transmission 5.089e-12 Highly Informative Direct
Biological Process (BP) nuclear import 4.113e-11 Highly Informative Direct
Biological Process (BP) stem cell development 9.894e-11 Highly Informative Direct
Biological Process (BP) regulation of MAP kinase activity 1.054e-10 Highly Informative Direct
Biological Process (BP) regulation of behavior 1.101e-10 Highly Informative Direct
Biological Process (BP) regulation of hormone secretion 3.625e-10 Highly Informative Direct
Biological Process (BP) aminoglycan catabolic process 6.146e-10 Highly Informative Direct
Biological Process (BP) protein import 3.047e-09 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 5.163e-09 Highly Informative Direct
Biological Process (BP) mitotic cell cycle phase transition 7.494e-09 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate biosynthetic process 1.032e-08 Highly Informative Direct
Biological Process (BP) positive regulation of response to external stimulus 3.869e-08 Highly Informative Direct
Biological Process (BP) regulation of production of molecular mediator of immune response 4.878e-08 Highly Informative Direct
Biological Process (BP) glycosaminoglycan metabolic process 6.732e-08 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 6.974e-08 Highly Informative Direct
Biological Process (BP) negative regulation of lipid biosynthetic process 4.516e-07 Highly Informative Direct
Biological Process (BP) purine ribonucleotide biosynthetic process 1.31e-06 Highly Informative Direct
Biological Process (BP) regulation of wound healing 1.446e-06 Highly Informative Direct
Biological Process (BP) cell junction organization 1.507e-06 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 1.519e-06 Highly Informative Direct
Biological Process (BP) modification of morphology or physiology of other organism involved in symbiotic interaction 6.072e-06 Highly Informative Direct
Biological Process (BP) regulation of reproductive process 6.469e-06 Highly Informative Direct
Biological Process (BP) cell cycle phase 6.756e-06 Highly Informative Direct
Biological Process (BP) positive regulation of MAPK cascade 7.447e-06 Highly Informative Direct
Biological Process (BP) female pregnancy 8.182e-06 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 1.003e-05 Highly Informative Direct
Biological Process (BP) regulation of cytokine biosynthetic process 1.703e-05 Highly Informative Direct
Biological Process (BP) regulation of mitosis 2.007e-05 Highly Informative Direct
Biological Process (BP) negative regulation of mitotic cell cycle phase transition 2.965e-05 Highly Informative Direct
Biological Process (BP) extrinsic apoptotic signaling pathway 4.766e-05 Highly Informative Direct
Biological Process (BP) connective tissue development 4.923e-05 Highly Informative Direct
Biological Process (BP) interaction with host 5.698e-05 Highly Informative Direct
Biological Process (BP) cell fate commitment 6.056e-05 Highly Informative Direct
Biological Process (BP) regulation of protein complex assembly 6.205e-05 Highly Informative Direct
Biological Process (BP) tube formation 7.402e-05 Highly Informative Direct
Biological Process (BP) cell cycle checkpoint 0.0001186 Highly Informative Direct
Biological Process (BP) positive regulation of protein kinase B signaling cascade 0.000134 Highly Informative Direct
Biological Process (BP) nuclear export 0.0001636 Highly Informative Direct
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.0002467 Highly Informative Direct
Biological Process (BP) endocrine system development 0.0002952 Highly Informative Direct
Biological Process (BP) negative regulation of neuron death 0.0003608 Highly Informative Direct
Biological Process (BP) regulation of mononuclear cell proliferation 0.0003842 Highly Informative Direct
Biological Process (BP) regulation of nucleocytoplasmic transport 0.0004039 Highly Informative Direct
Biological Process (BP) response to drug 0.0005496 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0.0006404 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 0.0007585 Highly Informative Direct
Biological Process (BP) exocytosis 0.0007677 Highly Informative Direct
Biological Process (BP) peptidyl-serine modification 0.0007919 Highly Informative Direct
Biological Process (BP) cellular response to starvation 0.0008326 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 0.0009641 Highly Informative Direct
Biological Process (BP) positive regulation of apoptotic signaling pathway 0.005595 Highly Informative Inherited
Biological Process (BP) regulation of binding 0.01374 Highly Informative Inherited
Biological Process (BP) positive regulation of peptidyl-tyrosine phosphorylation 0.002166 Highly Informative Inherited
Biological Process (BP) regulation of hemostasis 0.009396 Highly Informative Inherited
Biological Process (BP) regulation of inflammatory response 1 Highly Informative Inherited
Biological Process (BP) positive regulation of ion transport 1 Highly Informative Inherited
Biological Process (BP) regulation of calcium ion transport 0.0571 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.7287 Highly Informative Inherited
Biological Process (BP) cellular response to alcohol 0.5591 Highly Informative Inherited
Biological Process (BP) response to corticosteroid stimulus 1 Highly Informative Inherited
Biological Process (BP) response to lipopolysaccharide 0.00794 Highly Informative Inherited
Biological Process (BP) epithelial tube morphogenesis 0.01204 Highly Informative Inherited
Biological Process (BP) regulation of protein localization to nucleus 0.08117 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.2106 Highly Informative Inherited
Biological Process (BP) erythrocyte differentiation 0.6714 Highly Informative Inherited
Biological Process (BP) regulation of protein secretion 0.02499 Highly Informative Inherited
Biological Process (BP) positive regulation of protein transport 0.06034 Highly Informative Inherited
Biological Process (BP) cardiac muscle tissue development 0.03368 Highly Informative Inherited
Biological Process (BP) muscle fiber development 0.1892 Highly Informative Inherited
Biological Process (BP) negative regulation of secretion 0.06771 Highly Informative Inherited
Biological Process (BP) regulation of peptide transport 0.151 Highly Informative Inherited
Biological Process (BP) regulation of myeloid cell differentiation 0.031 Highly Informative Inherited
Biological Process (BP) positive regulation of lipid metabolic process 0.001086 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 0.8842 Highly Informative Inherited
Biological Process (BP) cellular response to organic cyclic compound 0.04723 Highly Informative Inherited
Biological Process (BP) hormone-mediated signaling pathway 0.7972 Highly Informative Inherited
Biological Process (BP) photoreceptor cell differentiation 0.1061 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 1 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.002522 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 1 Highly Informative Inherited
Biological Process (BP) signal release 0.1455 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.2389 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.7558 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.8866 Highly Informative Inherited
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 0.006111 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 1 Highly Informative Inherited
Biological Process (BP) positive regulation of secretion 0.004842 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 1 Highly Informative Inherited
Biological Process (BP) post-embryonic development 1 Highly Informative Inherited
Biological Process (BP) wound healing 0.02426 Highly Informative Inherited
Biological Process (BP) coagulation 0.1294 Highly Informative Inherited
Biological Process (BP) hemostasis 1 Highly Informative Inherited
Biological Process (BP) multi-organism cellular process 0.01233 Highly Informative Inherited
Biological Process (BP) cell division 0.7538 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.2539 Highly Informative Inherited
Biological Process (BP) regulation of coagulation 0.01445 Highly Informative Inherited
Biological Process (BP) neuron projection development 1 Highly Informative Inherited
Biological Process (BP) cell part morphogenesis 1 Highly Informative Inherited
Biological Process (BP) ATP metabolic process 0.005045 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.4132 Highly Informative Inherited
Biological Process (BP) regulation of blood pressure 0.1814 Highly Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 0.003587 Highly Informative Inherited
Biological Process (BP) regulation of neural precursor cell proliferation 0.03812 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) anion binding 3.184e-06 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0.00072 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) receptor binding 0 Informative Direct
Molecular Function (MF) sulfur compound binding 0 Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0 Informative Direct
Molecular Function (MF) protein dimerization activity 8.352e-13 Informative Direct
Molecular Function (MF) enzyme activator activity 1.125e-09 Informative Direct
Molecular Function (MF) amide binding 0.03756 Informative Inherited
Molecular Function (MF) molecular transducer activity 0.9621 Informative Inherited
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1 Informative Inherited
Molecular Function (MF) heparin binding 0 Highly Informative Direct
Molecular Function (MF) growth factor receptor binding 8.159e-06 Highly Informative Direct
Molecular Function (MF) cytokine receptor binding 9.622e-08 Highly Informative Direct
Molecular Function (MF) phosphatase regulator activity 1.933e-12 Highly Informative Direct
Molecular Function (MF) protein homodimerization activity 1.848e-06 Highly Informative Direct
Molecular Function (MF) peptide binding 0.000123 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0.9438 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) vesicle 7.268e-15 Moderately Informative Direct
Cellular Component (CC) cell projection 0.0009163 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 0.4123 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) extracellular space 0 Informative Direct
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) extracellular matrix 6.85e-13 Informative Direct
Cellular Component (CC) secretory granule 8.327e-12 Informative Direct
Cellular Component (CC) microvillus 1.521e-15 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 1.351e-11 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.127Least InformativeInherited
Disease Ontology (DO)benign neoplasm1.526e-07Moderately InformativeDirect
Disease Ontology (DO)lung disease0.000578Moderately InformativeDirect
Disease Ontology (DO)musculoskeletal system disease0.009687Moderately InformativeInherited
Disease Ontology (DO)skin disease0.06851Moderately InformativeInherited
Disease Ontology (DO)endocrine system disease0.09024Moderately InformativeInherited
Disease Ontology (DO)hematologic cancer0.3845Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.7406Moderately InformativeInherited
Disease Ontology (DO)prostate cancer0.0003706InformativeDirect
Disease Ontology (DO)arthropathy0.00322InformativeInherited
Disease Ontology (DO)myeloma0.01562InformativeInherited
Disease Ontology (DO)organ system benign neoplasm0.208InformativeInherited
Disease Ontology (DO)colonic disease0.006273Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Multifactorial inheritance7.163e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the skeletal system0.05157Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of head and neck0.1115Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hand0.008067Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digits0.04008Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.9267Moderately InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving bones of the lower limbs0.03629InformativeInherited
Phenotypic Abnormality (PA)Abnormal facial shape0.2068InformativeInherited
Phenotypic Abnormality (PA)Abnormality of toe0.4959InformativeInherited
Phenotypic Abnormality (PA)Abnormality of phalanx of finger0.924InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the middle phalanges of the hand4.284e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Facial asymmetry0.0001845Highly InformativeDirect
Phenotypic Abnormality (PA)Broad toe0.001704Highly InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia of toe0.003696Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the phalanges of the toes0.01214Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hallux0.01901Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the 5th finger0.2366Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)