SUPERFAMILY 1.75 HMM library and genome assignments server

Kringle-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Kringle-like [ 57439]
Superfamily:   Kringle-like [ 57440] (2)
Families:   Kringle modules [ 57441] (6)
  Fibronectin type II module [ 57459] (4)


Superfamily statistics
Genomes (180) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 5,280 5,786 59
Proteins 2,987 3,215 47


Functional annotation
General category Processes_EC
Detailed category Blood clotting

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) developmental process 0.000000000000472 Least Informative Direct
Biological Process (BP) response to stimulus 0.000000001147 Least Informative Direct
Biological Process (BP) protein metabolic process 0.000000005637 Least Informative Direct
Biological Process (BP) localization 0.00002399 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.8992 Least Informative Inherited
Biological Process (BP) positive regulation of biological process 0.07709 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.00663 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.1041 Least Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.000000002675 Moderately Informative Direct
Biological Process (BP) reproductive process 0.00000005863 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0.000000225 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.00001143 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.00009918 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.0008766 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.5162 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.6943 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.9336 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.6061 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.5022 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.1944 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.776 Moderately Informative Inherited
Biological Process (BP) regulation of phosphorus metabolic process 0.05673 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.6125 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.1687 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.08567 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.7496 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.07325 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.6125 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.00514 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.3247 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.227 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.08693 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.1979 Moderately Informative Inherited
Biological Process (BP) tissue development 0.4499 Moderately Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.000000001339 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0.000000003211 Informative Direct
Biological Process (BP) locomotion 0.00000002102 Informative Direct
Biological Process (BP) biological adhesion 0.00000003949 Informative Direct
Biological Process (BP) secretion by cell 0.00000005369 Informative Direct
Biological Process (BP) regulation of body fluid levels 0.0000001389 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 0.0000002847 Informative Direct
Biological Process (BP) regulation of peptidase activity 0.0000007237 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.0000007408 Informative Direct
Biological Process (BP) single organism reproductive process 0.000006125 Informative Direct
Biological Process (BP) cellular component movement 0.000007715 Informative Direct
Biological Process (BP) multi-multicellular organism process 0.00001267 Informative Direct
Biological Process (BP) localization of cell 0.00001274 Informative Direct
Biological Process (BP) phosphorylation 0.00003192 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.00006292 Informative Direct
Biological Process (BP) proteolysis 0.000149 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.0002648 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 0.000581 Informative Direct
Biological Process (BP) regulation of growth 0.0006894 Informative Direct
Biological Process (BP) regulation of response to wounding 0.0007213 Informative Direct
Biological Process (BP) regulation of cell development 0.0009195 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.009766 Informative Inherited
Biological Process (BP) regulation of locomotion 0.02194 Informative Inherited
Biological Process (BP) positive regulation of gene expression 0.05343 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.06683 Informative Inherited
Biological Process (BP) regulation of transferase activity 0.35 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.01107 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.05188 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.003234 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.01127 Informative Inherited
Biological Process (BP) organ morphogenesis 0.8083 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.1129 Informative Inherited
Biological Process (BP) embryonic organ development 0.007012 Informative Inherited
Biological Process (BP) sensory organ development 0.2134 Informative Inherited
Biological Process (BP) protein maturation 0.006864 Informative Inherited
Biological Process (BP) reproductive structure development 0.1438 Informative Inherited
Biological Process (BP) generation of neurons 0.1033 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.01482 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.02596 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.01978 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.3735 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.07981 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.002661 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.8346 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.01674 Informative Inherited
Biological Process (BP) gland development 0.05171 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.06437 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.06047 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.1193 Informative Inherited
Biological Process (BP) multicellular organismal catabolic process 0 Highly Informative Direct
Biological Process (BP) collagen metabolic process 0 Highly Informative Direct
Biological Process (BP) hemostasis 0 Highly Informative Direct
Biological Process (BP) regulation of cell size 0.00000000008834 Highly Informative Direct
Biological Process (BP) coagulation 0.000000001125 Highly Informative Direct
Biological Process (BP) exocytosis 0.000000002547 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 0.000000005161 Highly Informative Direct
Biological Process (BP) cell junction organization 0.000000008041 Highly Informative Direct
Biological Process (BP) cell adhesion 0.00000001004 Highly Informative Direct
Biological Process (BP) negative regulation of hemostasis 0.00000003034 Highly Informative Direct
Biological Process (BP) negative regulation of coagulation 0.00000006443 Highly Informative Direct
Biological Process (BP) female pregnancy 0.00000009161 Highly Informative Direct
Biological Process (BP) stress-activated protein kinase signaling cascade 0.0000003314 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0.0000004001 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.0000006695 Highly Informative Direct
Biological Process (BP) protein phosphorylation 0.000001879 Highly Informative Direct
Biological Process (BP) zymogen activation 0.000002 Highly Informative Direct
Biological Process (BP) positive regulation of growth 0.000003842 Highly Informative Direct
Biological Process (BP) regulation of wound healing 0.00001215 Highly Informative Direct
Biological Process (BP) MAPK cascade 0.00007362 Highly Informative Direct
Biological Process (BP) regulation of organ morphogenesis 0.00008861 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0.0002084 Highly Informative Direct
Biological Process (BP) skeletal system development 0.0003489 Highly Informative Direct
Biological Process (BP) wound healing 0.0004441 Highly Informative Direct
Biological Process (BP) positive regulation of neurogenesis 0.0006552 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.000856 Highly Informative Direct
Biological Process (BP) negative regulation of response to wounding 0.001175 Highly Informative Inherited
Biological Process (BP) negative regulation of transferase activity 0.01186 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.02391 Highly Informative Inherited
Biological Process (BP) ear development 0.01396 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.008398 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.2496 Highly Informative Inherited
Biological Process (BP) connective tissue development 0.002445 Highly Informative Inherited
Molecular Function (MF) binding 0.000009983 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.00009475 Least Informative Direct
Molecular Function (MF) transferase activity 0.5925 Least Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.000003295 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.000009538 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.00001157 Moderately Informative Direct
Molecular Function (MF) peptidase activity 0 Informative Direct
Molecular Function (MF) peptidase regulator activity 0.0000000000003041 Informative Direct
Molecular Function (MF) receptor activity 0.000000000002613 Informative Direct
Molecular Function (MF) molecular transducer activity 0.000000009949 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.0000002013 Informative Direct
Molecular Function (MF) kinase activity 0.0000009416 Informative Direct
Molecular Function (MF) receptor binding 0.0002774 Informative Direct
Molecular Function (MF) enzyme activator activity 0.0005954 Informative Direct
Molecular Function (MF) monosaccharide binding 0 Highly Informative Direct
Molecular Function (MF) serine hydrolase activity 0.000000000000001593 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0.000000002866 Highly Informative Direct
Molecular Function (MF) endopeptidase activity 0.00005964 Highly Informative Direct
Molecular Function (MF) transmembrane signaling receptor activity 0.0809 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.8251 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane part 0.00000000000001325 Moderately Informative Direct
Cellular Component (CC) vesicle 0.000008974 Moderately Informative Direct
Cellular Component (CC) cell projection 0.004556 Moderately Informative Inherited
Cellular Component (CC) membrane region 0.5451 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 0.004749 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.7001 Moderately Informative Inherited
Cellular Component (CC) extracellular matrix 0.00000000000000158 Informative Direct
Cellular Component (CC) cell surface 0.0000009142 Informative Direct
Cellular Component (CC) nuclear envelope 0.000007227 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 0.00001105 Informative Direct
Cellular Component (CC) neuron projection 0.0001295 Informative Direct
Cellular Component (CC) plasma membrane region 0.01609 Informative Inherited
Cellular Component (CC) extracellular matrix part 0.000000000001246 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 0.00008102 Highly Informative Direct
Cellular Component (CC) proteinaceous extracellular matrix 0.00806 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0.0000000000001313Moderately InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0.000000000001212InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0.0002463InformativeDirect
Enzyme Commission (EC)Plasmin0Highly InformativeDirect
Enzyme Commission (EC)T-plasminogen activator0.000000000000002098Highly InformativeDirect
Enzyme Commission (EC)Gelatinase B0.0000000001879Highly InformativeDirect
Enzyme Commission (EC)Gelatinase A0.0000000001879Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.0217Least InformativeInherited
Disease Ontology (DO)organ system cancer0.02688Least InformativeInherited
Disease Ontology (DO)artery disease0.00008226Moderately InformativeDirect
Disease Ontology (DO)urinary system disease0.0002858Moderately InformativeDirect
Disease Ontology (DO)syndrome0.0009169Moderately InformativeDirect
Disease Ontology (DO)skin disease0.00141Moderately InformativeInherited
Disease Ontology (DO)mouth disease0.01102Moderately InformativeInherited
Disease Ontology (DO)hematologic cancer0.04753Moderately InformativeInherited
Disease Ontology (DO)nervous system cancer0.2036Moderately InformativeInherited
Disease Ontology (DO)sensory system disease0.2863Moderately InformativeInherited
Disease Ontology (DO)muscular disease0.3513Moderately InformativeInherited
Disease Ontology (DO)atherosclerosis0.0000000556InformativeDirect
Disease Ontology (DO)laryngeal carcinoma0.00008674InformativeDirect
Disease Ontology (DO)connective tissue cancer0.0001325InformativeDirect
Disease Ontology (DO)liver disease0.000703InformativeDirect
Disease Ontology (DO)lung carcinoma0.0007467InformativeDirect
Disease Ontology (DO)female reproductive system disease0.0008236InformativeDirect
Disease Ontology (DO)meningioma0.0009196InformativeDirect
Disease Ontology (DO)myositis0.001309InformativeInherited
Disease Ontology (DO)auditory system disease0.002591InformativeInherited
Disease Ontology (DO)coronary artery disease0.003116InformativeInherited
Disease Ontology (DO)lymphoma0.007861InformativeInherited
Disease Ontology (DO)endocrine gland cancer0.009474InformativeInherited
Disease Ontology (DO)eye disease0.06474InformativeInherited
Disease Ontology (DO)meningitis0.00004043Highly InformativeDirect
Disease Ontology (DO)Hodgkin's lymphoma0.00006193Highly InformativeDirect
Disease Ontology (DO)dermatomyositis0.000106Highly InformativeDirect
Disease Ontology (DO)leukodystrophy0.0001178Highly InformativeDirect
Disease Ontology (DO)pancreatic ductal adenocarcinoma0.0001909Highly InformativeDirect
Disease Ontology (DO)endometriosis0.0002254Highly InformativeDirect
Disease Ontology (DO)cerebrovascular disease0.001685Highly InformativeInherited
Disease Ontology (DO)keratosis0.02448Highly InformativeInherited
Disease Ontology (DO)interstitial lung disease0.1258Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of head and neck0.7295Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the mouth0.4334Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the oral cavity0.305InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gingiva0.0001928Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.04069Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.1896Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.2223Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.7136Least InformativeInherited
Mammalian Phenotype (MP)digestive/alimentary phenotype0.009729Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.01008Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.09334Moderately InformativeInherited
Mammalian Phenotype (MP)tumorigenesis0.1132Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.1246Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.1534Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.2078Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.224Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.4098Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.8084Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal uvea morphology0.0002232InformativeDirect
Mammalian Phenotype (MP)abnormal lung morphology0.0003113InformativeDirect
Mammalian Phenotype (MP)abnormal response to injury0.001062InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton physiology0.0015InformativeInherited
Mammalian Phenotype (MP)abnormal limb morphology0.002322InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel physiology0.07346InformativeInherited
Mammalian Phenotype (MP)abnormal intestine morphology0.2235InformativeInherited
Mammalian Phenotype (MP)decreased susceptibility to induced choroidal neovascularization0.0000000001555Highly InformativeDirect
Mammalian Phenotype (MP)arthritis0.00008236Highly InformativeDirect
Mammalian Phenotype (MP)decreased tumor growth/size0.0004307Highly InformativeDirect
Mammalian Phenotype (MP)altered response to CNS ischemic injury0.0006132Highly InformativeDirect
Mammalian Phenotype (MP)abnormal digit morphology0.00713Highly InformativeInherited
Mammalian Phenotype (MP)altered metastatic potential0.1278Highly InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to atherosclerosis0.3525Highly InformativeInherited

Document: MP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.1781Least InformativeInherited
Xenopus ANatomical entity (XAN)portion of tissue0.483Least InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.8661Moderately InformativeInherited
Xenopus ANatomical entity (XAN)mesenchyme0.0005266InformativeDirect
Xenopus ANatomical entity (XAN)notochord0.0009234InformativeDirect
Xenopus ANatomical entity (XAN)neural plate0.03129InformativeInherited
Xenopus ANatomical entity (XAN)epithelium0.0001613Highly InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups0.9169Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0.00000000000008138InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0.0000000000547InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0.0002291InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0.0000000000008387Highly InformativeDirect

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)blood and blood forming organs0.002778Least InformativeInherited
Drugbank ATC_code (DB)antithrombotic agents1Moderately InformativeInherited
Drugbank ATC_code (DB)enzymes0.000003359InformativeDirect
Drugbank ATC_code (DB)amino acids0.00000002908Highly InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processHemostasis0InformativeDirect
Biological processAngiogenesis0.000000000000009811InformativeDirect
Biological processEndocytosis0.00000000001645InformativeDirect
Biological processWnt signaling pathway0.000000006951InformativeDirect
Biological processCell adhesion0.00001062InformativeDirect
Biological processAcute phase0Highly InformativeDirect
Biological processBlood coagulation0Highly InformativeDirect
Biological processFertilization0Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentExtracellular matrix0.000002273InformativeDirect
DomainRepeat0Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainEGF-like domain0InformativeDirect
DomainKringle0Highly InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionHeparin-binding0.00000000000008025InformativeDirect
Molecular functionLectin0.000000001859InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationReceptor0.000000000007498Moderately InformativeDirect
Post-translational modificationKinase0.3946Moderately InformativeInherited
Post-translational modificationSerine protease0InformativeDirect
Post-translational modificationGrowth factor0.0000001347InformativeDirect
Post-translational modificationTyrosine-protein kinase0.0000000003948Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues0.000000000001484Moderately InformativeDirect
Post-translational modificationZymogen0InformativeDirect
Post-translational modificationPyrrolidone carboxylic acid0.000000506InformativeDirect
Post-translational modificationSulfation0.00001654InformativeDirect
Post-translational modificationGamma-carboxyglutamic acid0.00000002759Highly InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR013806 SSF57440 Protein matches
Abstract

This entry represents proteins displaying a Kringle-like structure, which consists of a nearly all-beta, disulphide-rich fold. Proteins displaying this fold include both Kringle modules as well as fibronectin type II modules, the latter displaying a shorter two-disulphide version of the Kringle module.

Kringle modules occur in blood clotting and fibrinolytic proteins, such as plasminogen, prothrombin, meizothrombin, and urokinase-type plasminogen activator, as well as in apolipoprotein and hepatocyte growth factor. Kringle domains are believed to play a role in binding mediators (e.g., membranes, other proteins or phospholipids), and in the regulation of proteolytic activity [PubMed6373375, PubMed2157850].

Fibronectin type II modules occur in fibronectin, as well as in gelatinase A (MMP-2), gelatinase B (MMP-9), and the collagen-binding domain of PDC-109. Fibronectin is a multi-domain glycoprotein, found in a soluble form in plasma, and in an insoluble form in loose connective tissue and basement membranes, that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin [PubMed3780752]. Fibronectins are involved in a number of important functions e.g., wound healing; cell adhesion; blood coagulation; cell differentiation and migration; maintenance of the cellular cytoskeleton; and tumour metastasis. Gelatinases A and B are members of the matrix metalloproteinase family that act as neutral proteinases in the breakdown and remodelling of the extracellular matrix. These gelatinases play important roles in the pathogenesis of inflammation, infection and in neoplastic diseases [PubMed16019990]. In gelatinase A, the three fibronectin-like modules are inserted within a catalytic domain, these modules acting to target the enzyme to matrix macromolecules [PubMed16085117].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 24 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Kringle-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 24 hidden Markov models representing the Kringle-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · Internal database links ]