SUPERFAMILY 1.75 HMM library and genome assignments server


Kringle-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Kringle-like [ 57439]
Superfamily:   Kringle-like [ 57440] (2)
Families:   Kringle modules [ 57441] (6)
  Fibronectin type II module [ 57459] (4)


Superfamily statistics
Genomes (174) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 4,956 5,786 59
Proteins 2,813 3,215 47


Functional annotation
General category Processes_EC
Detailed category Blood clotting

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) developmental process 4.489e-13 Least Informative Direct
Biological Process (BP) response to stimulus 1.937e-10 Least Informative Direct
Biological Process (BP) protein metabolic process 1.656e-09 Least Informative Direct
Biological Process (BP) localization 7.006e-06 Least Informative Direct
Biological Process (BP) single-organism cellular process 2.049e-05 Least Informative Direct
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.002366 Least Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1.413e-08 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 3.919e-07 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 1.014e-05 Moderately Informative Direct
Biological Process (BP) reproduction 1.611e-05 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.6284 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.9172 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.2767 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.661 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.1167 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.1494 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.001554 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.374 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.8302 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.6554 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.7415 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.5655 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.6003 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.01067 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.375 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.2928 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.09055 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.03935 Moderately Informative Inherited
Biological Process (BP) biological adhesion 6.969e-14 Informative Direct
Biological Process (BP) response to wounding 1.152e-13 Informative Direct
Biological Process (BP) regulation of peptidase activity 1.352e-11 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 2.492e-09 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 2.559e-09 Informative Direct
Biological Process (BP) locomotion 1.305e-08 Informative Direct
Biological Process (BP) regulation of body fluid levels 1.196e-07 Informative Direct
Biological Process (BP) secretion by cell 7.351e-07 Informative Direct
Biological Process (BP) vesicle-mediated transport 1.12e-06 Informative Direct
Biological Process (BP) phosphorylation 5.43e-06 Informative Direct
Biological Process (BP) localization of cell 1.66e-05 Informative Direct
Biological Process (BP) regulation of apoptotic process 3.844e-05 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 5.815e-05 Informative Direct
Biological Process (BP) proteolysis 0.0001277 Informative Direct
Biological Process (BP) cellular component movement 0.0001775 Informative Direct
Biological Process (BP) embryonic organ development 0.0007108 Informative Direct
Biological Process (BP) regulation of growth 0.0008168 Informative Direct
Biological Process (BP) regulation of kinase activity 0.1187 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.189 Informative Inherited
Biological Process (BP) regulation of response to stress 0.02981 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.7819 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.01553 Informative Inherited
Biological Process (BP) generation of neurons 0.1029 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.3555 Informative Inherited
Biological Process (BP) regulation of cell development 0.001045 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.0368 Informative Inherited
Biological Process (BP) reproductive system development 0.4605 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.8573 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.01497 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.002174 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.001868 Informative Inherited
Biological Process (BP) sensory organ development 0.0527 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.2037 Informative Inherited
Biological Process (BP) organ morphogenesis 0.373 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.02451 Informative Inherited
Biological Process (BP) regulation of locomotion 0.05538 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.002001 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.005292 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.03398 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.07334 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.08074 Informative Inherited
Biological Process (BP) single organism reproductive process 0.003648 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 1 Informative Inherited
Biological Process (BP) sexual reproduction 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.2335 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.113 Informative Inherited
Biological Process (BP) hemostasis 0 Highly Informative Direct
Biological Process (BP) multicellular organismal metabolic process 1.741e-12 Highly Informative Direct
Biological Process (BP) regulation of cell size 3.371e-11 Highly Informative Direct
Biological Process (BP) coagulation 9.146e-10 Highly Informative Direct
Biological Process (BP) cell adhesion 1.195e-09 Highly Informative Direct
Biological Process (BP) peptidyl-tyrosine modification 1.703e-09 Highly Informative Direct
Biological Process (BP) exocytosis 2.184e-09 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 2.834e-09 Highly Informative Direct
Biological Process (BP) regulation of hemostasis 3.827e-08 Highly Informative Direct
Biological Process (BP) regulation of coagulation 6.594e-08 Highly Informative Direct
Biological Process (BP) cell junction organization 8.275e-08 Highly Informative Direct
Biological Process (BP) regulation of wound healing 1.197e-07 Highly Informative Direct
Biological Process (BP) regulation of cell growth 1.536e-07 Highly Informative Direct
Biological Process (BP) positive regulation of peptidase activity 3.126e-07 Highly Informative Direct
Biological Process (BP) wound healing 3.13e-07 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 3.374e-07 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 4.974e-07 Highly Informative Direct
Biological Process (BP) stress-activated protein kinase signaling cascade 1.908e-06 Highly Informative Direct
Biological Process (BP) positive regulation of growth 2.695e-06 Highly Informative Direct
Biological Process (BP) protein phosphorylation 4.265e-06 Highly Informative Direct
Biological Process (BP) protein processing 8.863e-06 Highly Informative Direct
Biological Process (BP) MAPK cascade 6.319e-05 Highly Informative Direct
Biological Process (BP) regulation of organ morphogenesis 9.576e-05 Highly Informative Direct
Biological Process (BP) female pregnancy 0.0001335 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0.0003023 Highly Informative Direct
Biological Process (BP) skeletal system development 0.0003175 Highly Informative Direct
Biological Process (BP) spermatogenesis 0.0009085 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.01111 Highly Informative Inherited
Biological Process (BP) connective tissue development 0.001071 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.001417 Highly Informative Inherited
Biological Process (BP) positive regulation of cell differentiation 0.002843 Highly Informative Inherited
Biological Process (BP) inner ear development 0.005632 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.001722 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.2405 Highly Informative Inherited
Molecular Function (MF) binding 1.633e-06 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.0001044 Least Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 6.038e-06 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 1.799e-05 Moderately Informative Direct
Molecular Function (MF) peptidase activity 0 Informative Direct
Molecular Function (MF) peptidase regulator activity 2.123e-13 Informative Direct
Molecular Function (MF) receptor activity 2.429e-12 Informative Direct
Molecular Function (MF) molecular transducer activity 9.159e-09 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1.301e-07 Informative Direct
Molecular Function (MF) kinase activity 6.181e-07 Informative Direct
Molecular Function (MF) enzyme activator activity 4.707e-05 Informative Direct
Molecular Function (MF) receptor binding 0.0002424 Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.000924 Informative Direct
Molecular Function (MF) monosaccharide binding 0 Highly Informative Direct
Molecular Function (MF) protein kinase activity 1.855e-09 Highly Informative Direct
Molecular Function (MF) endopeptidase activity 6.092e-05 Highly Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.993 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) vesicle 2.937e-06 Moderately Informative Direct
Cellular Component (CC) cell projection 0.00276 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 0.004017 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.01248 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.7842 Moderately Informative Inherited
Cellular Component (CC) extracellular matrix 0 Informative Direct
Cellular Component (CC) cell surface 3.249e-07 Informative Direct
Cellular Component (CC) nuclear envelope 1.195e-06 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 2.58e-06 Informative Direct
Cellular Component (CC) neuron projection 0.0001726 Informative Direct
Cellular Component (CC) extracellular matrix part 1.44e-12 Highly Informative Direct
Cellular Component (CC) proteinaceous extracellular matrix 0.01485 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Serine endopeptidases1.313e-13Moderately InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase1.212e-12InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0.0002463InformativeDirect
Enzyme Commission (EC)Plasmin0Highly InformativeDirect
Enzyme Commission (EC)T-plasminogen activator2.098e-15Highly InformativeDirect
Enzyme Commission (EC)Gelatinase B1.879e-10Highly InformativeDirect
Enzyme Commission (EC)Gelatinase A1.879e-10Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.02581Least InformativeInherited
Disease Ontology (DO)nervous system disease0.03103Least InformativeInherited
Disease Ontology (DO)artery disease8.005e-05Moderately InformativeDirect
Disease Ontology (DO)urinary system disease0.0002632Moderately InformativeDirect
Disease Ontology (DO)lung disease0.0009209Moderately InformativeDirect
Disease Ontology (DO)syndrome0.0009329Moderately InformativeDirect
Disease Ontology (DO)skin disease0.001379Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.007248Moderately InformativeInherited
Disease Ontology (DO)hematologic cancer0.04729Moderately InformativeInherited
Disease Ontology (DO)musculoskeletal system disease0.0537Moderately InformativeInherited
Disease Ontology (DO)nervous system cancer0.1864Moderately InformativeInherited
Disease Ontology (DO)sensory system disease0.3528Moderately InformativeInherited
Disease Ontology (DO)brain disease0.4659Moderately InformativeInherited
Disease Ontology (DO)laryngeal carcinoma9.086e-05InformativeDirect
Disease Ontology (DO)myopia9.409e-05InformativeDirect
Disease Ontology (DO)liver disease0.0006636InformativeDirect
Disease Ontology (DO)lung carcinoma0.0007624InformativeDirect
Disease Ontology (DO)female reproductive system disease0.0007653InformativeDirect
Disease Ontology (DO)meningioma0.0008423InformativeDirect
Disease Ontology (DO)leukodystrophy0.0009826InformativeDirect
Disease Ontology (DO)auditory system disease0.001288InformativeInherited
Disease Ontology (DO)coronary artery disease0.003131InformativeInherited
Disease Ontology (DO)lymphoma0.007585InformativeInherited
Disease Ontology (DO)endocrine gland cancer0.009245InformativeInherited
Disease Ontology (DO)muscular disease0.1502InformativeInherited
Disease Ontology (DO)connective tissue cancer0.432InformativeInherited
Disease Ontology (DO)meningitis4.039e-05Highly InformativeDirect
Disease Ontology (DO)Hodgkin's lymphoma6.56e-05Highly InformativeDirect
Disease Ontology (DO)osteosarcoma6.852e-05Highly InformativeDirect
Disease Ontology (DO)dermatomyositis0.0001169Highly InformativeDirect
Disease Ontology (DO)endometriosis0.0002072Highly InformativeDirect
Disease Ontology (DO)cerebrovascular disease0.001645Highly InformativeInherited
Disease Ontology (DO)keratosis0.02285Highly InformativeInherited
Disease Ontology (DO)interstitial lung disease0.113Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of head and neck0.7339Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the mouth0.4379Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the oral cavity0.3099InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gingiva0.0001807Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.0391Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.1873Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.2183Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.7862Least InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.009612Moderately InformativeInherited
Mammalian Phenotype (MP)digestive/alimentary phenotype0.02711Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.06135Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.1201Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.1467Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.1998Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.2245Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.4015Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.8012Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal uvea morphology0.0002141InformativeDirect
Mammalian Phenotype (MP)abnormal lung morphology0.0003053InformativeDirect
Mammalian Phenotype (MP)abnormal response to injury0.0005449InformativeDirect
Mammalian Phenotype (MP)abnormal skeleton physiology0.001515InformativeInherited
Mammalian Phenotype (MP)abnormal limb morphology0.002229InformativeInherited
Mammalian Phenotype (MP)arteriosclerosis0.009318InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel physiology0.06772InformativeInherited
Mammalian Phenotype (MP)abnormal intestine morphology0.09618InformativeInherited
Mammalian Phenotype (MP)decreased susceptibility to induced choroidal neovascularization1.643e-10Highly InformativeDirect
Mammalian Phenotype (MP)arthritis8.154e-05Highly InformativeDirect
Mammalian Phenotype (MP)decreased tumor growth/size0.0004236Highly InformativeDirect
Mammalian Phenotype (MP)altered response to CNS ischemic injury0.0005329Highly InformativeDirect
Mammalian Phenotype (MP)abnormal digit morphology0.006762Highly InformativeInherited
Mammalian Phenotype (MP)altered metastatic potential0.128Highly InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to atherosclerosis0.3517Highly InformativeInherited

Document: MP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.1755Least InformativeInherited
Xenopus ANatomical entity (XAN)portion of tissue0.4803Least InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.8622Moderately InformativeInherited
Xenopus ANatomical entity (XAN)mesenchyme0.0004645InformativeDirect
Xenopus ANatomical entity (XAN)notochord0.0008614InformativeDirect
Xenopus ANatomical entity (XAN)neural plate0.02774InformativeInherited
Xenopus ANatomical entity (XAN)neural groove1.802e-05Highly InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups0.9195Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases8.338e-14InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases5.617e-11InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0.0002316InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase8.628e-13Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processHemostasis0InformativeDirect
Biological processAngiogenesis1.002e-14InformativeDirect
Biological processEndocytosis1.554e-11InformativeDirect
Biological processWnt signaling pathway7.018e-09InformativeDirect
Biological processCell adhesion1.059e-05InformativeDirect
Biological processAcute phase0Highly InformativeDirect
Biological processBlood coagulation0Highly InformativeDirect
Biological processFertilization0Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentExtracellular matrix2.35e-06InformativeDirect
DomainRepeat0Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainEGF-like domain0InformativeDirect
DomainKringle0Highly InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionHeparin-binding8.22e-14InformativeDirect
Molecular functionLectin1.434e-09InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationReceptor7.769e-12Moderately InformativeDirect
Post-translational modificationKinase0.3942Moderately InformativeInherited
Post-translational modificationSerine protease0InformativeDirect
Post-translational modificationGrowth factor1.367e-07InformativeDirect
Post-translational modificationTyrosine-protein kinase4.023e-10Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues1.598e-12Moderately InformativeDirect
Post-translational modificationZymogen0InformativeDirect
Post-translational modificationPyrrolidone carboxylic acid5.258e-07InformativeDirect
Post-translational modificationSulfation1.655e-05InformativeDirect
Post-translational modificationGamma-carboxyglutamic acid2.824e-08Highly InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR013806 SSF57440 Protein matches
Abstract

This entry represents proteins displaying a Kringle-like structure, which consists of a nearly all-beta, disulphide-rich fold. Proteins displaying this fold include both Kringle modules as well as fibronectin type II modules, the latter displaying a shorter two-disulphide version of the Kringle module.

Kringle modules occur in blood clotting and fibrinolytic proteins, such as plasminogen, prothrombin, meizothrombin, and urokinase-type plasminogen activator, as well as in apolipoprotein and hepatocyte growth factor. Kringle domains are believed to play a role in binding mediators (e.g., membranes, other proteins or phospholipids), and in the regulation of proteolytic activity [PubMed6373375, PubMed2157850].

Fibronectin type II modules occur in fibronectin, as well as in gelatinase A (MMP-2), gelatinase B (MMP-9), and the collagen-binding domain of PDC-109. Fibronectin is a multi-domain glycoprotein, found in a soluble form in plasma, and in an insoluble form in loose connective tissue and basement membranes, that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin [PubMed3780752]. Fibronectins are involved in a number of important functions e.g., wound healing; cell adhesion; blood coagulation; cell differentiation and migration; maintenance of the cellular cytoskeleton; and tumour metastasis. Gelatinases A and B are members of the matrix metalloproteinase family that act as neutral proteinases in the breakdown and remodelling of the extracellular matrix. These gelatinases play important roles in the pathogenesis of inflammation, infection and in neoplastic diseases [PubMed16019990]. In gelatinase A, the three fibronectin-like modules are inserted within a catalytic domain, these modules acting to target the enzyme to matrix macromolecules [PubMed16085117].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 24 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Kringle-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 24 hidden Markov models representing the Kringle-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]