SUPERFAMILY 1.75 HMM library and genome assignments server


Kringle-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Kringle-like [ 57439]
Superfamily:   Kringle-like [ 57440] (2)
Families:   Kringle modules [ 57441] (6)
  Fibronectin type II module [ 57459] (4)


Superfamily statistics
Genomes (166) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 4,850 4,938 59
Proteins 2,755 2,717 47


Functional annotation
General category Processes_EC
Detailed category Blood clotting

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) developmental process 2.233e-11 Least Informative Direct
Biological Process (BP) protein metabolic process 2.192e-09 Least Informative Direct
Biological Process (BP) response to stimulus 2.606e-09 Least Informative Direct
Biological Process (BP) single-organism cellular process 3.833e-05 Least Informative Direct
Biological Process (BP) localization 4.644e-05 Least Informative Direct
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.008649 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 6.412e-09 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 4.362e-07 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 5.758e-06 Moderately Informative Direct
Biological Process (BP) reproduction 1.873e-05 Moderately Informative Direct
Biological Process (BP) regulation of programmed cell death 0.0001188 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.5713 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.8843 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.3792 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.5575 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.08466 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.1276 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.001852 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.4361 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.885 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.595 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.7305 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.6311 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.3215 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.01139 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.2788 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.3426 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.1007 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.04579 Moderately Informative Inherited
Biological Process (BP) biological adhesion 7.645e-14 Informative Direct
Biological Process (BP) response to wounding 1.359e-13 Informative Direct
Biological Process (BP) regulation of peptidase activity 1.731e-11 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 2.419e-09 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 2.941e-09 Informative Direct
Biological Process (BP) regulation of body fluid levels 1.005e-07 Informative Direct
Biological Process (BP) locomotion 2.8e-07 Informative Direct
Biological Process (BP) vesicle-mediated transport 4.388e-07 Informative Direct
Biological Process (BP) secretion by cell 5.292e-07 Informative Direct
Biological Process (BP) phosphorylation 6.858e-06 Informative Direct
Biological Process (BP) localization of cell 2.711e-05 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 6.762e-05 Informative Direct
Biological Process (BP) proteolysis 0.0001346 Informative Direct
Biological Process (BP) embryonic organ development 0.0004212 Informative Direct
Biological Process (BP) cellular component movement 0.0006716 Informative Direct
Biological Process (BP) regulation of growth 0.0007088 Informative Direct
Biological Process (BP) regulation of kinase activity 0.1265 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.1838 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.712 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.0155 Informative Inherited
Biological Process (BP) generation of neurons 0.1224 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.3377 Informative Inherited
Biological Process (BP) regulation of cell development 0.001016 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.03602 Informative Inherited
Biological Process (BP) reproductive structure development 0.3295 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.01528 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.001749 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.001152 Informative Inherited
Biological Process (BP) sensory organ development 0.175 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.3088 Informative Inherited
Biological Process (BP) organ morphogenesis 0.2804 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.0223 Informative Inherited
Biological Process (BP) regulation of locomotion 0.05175 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.002064 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.004935 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.03197 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.07025 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.009818 Informative Inherited
Biological Process (BP) single organism reproductive process 0.002458 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 1 Informative Inherited
Biological Process (BP) sexual reproduction 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.1839 Informative Inherited
Biological Process (BP) collagen metabolic process 0 Highly Informative Direct
Biological Process (BP) multicellular organismal catabolic process 0 Highly Informative Direct
Biological Process (BP) hemostasis 0 Highly Informative Direct
Biological Process (BP) regulation of cell size 2.981e-11 Highly Informative Direct
Biological Process (BP) cell adhesion 3.775e-10 Highly Informative Direct
Biological Process (BP) coagulation 8.935e-10 Highly Informative Direct
Biological Process (BP) peptidyl-tyrosine modification 1.835e-09 Highly Informative Direct
Biological Process (BP) exocytosis 2.716e-09 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 3.252e-09 Highly Informative Direct
Biological Process (BP) regulation of hemostasis 2.933e-08 Highly Informative Direct
Biological Process (BP) regulation of coagulation 5.235e-08 Highly Informative Direct
Biological Process (BP) cell junction organization 6.284e-08 Highly Informative Direct
Biological Process (BP) regulation of wound healing 7.077e-08 Highly Informative Direct
Biological Process (BP) regulation of cell growth 1.414e-07 Highly Informative Direct
Biological Process (BP) wound healing 2.776e-07 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 3.952e-07 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 6.905e-07 Highly Informative Direct
Biological Process (BP) stress-activated protein kinase signaling cascade 2.245e-06 Highly Informative Direct
Biological Process (BP) positive regulation of growth 3.219e-06 Highly Informative Direct
Biological Process (BP) positive regulation of peptidase activity 3.501e-06 Highly Informative Direct
Biological Process (BP) protein phosphorylation 4.102e-06 Highly Informative Direct
Biological Process (BP) protein processing 1.018e-05 Highly Informative Direct
Biological Process (BP) MAPK cascade 8.098e-05 Highly Informative Direct
Biological Process (BP) regulation of organ morphogenesis 8.822e-05 Highly Informative Direct
Biological Process (BP) female pregnancy 0.0001603 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0.0002445 Highly Informative Direct
Biological Process (BP) spermatogenesis 0.0009724 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.01137 Highly Informative Inherited
Biological Process (BP) connective tissue development 0.001073 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.001425 Highly Informative Inherited
Biological Process (BP) positive regulation of cell differentiation 0.002768 Highly Informative Inherited
Biological Process (BP) skeletal system development 0.001042 Highly Informative Inherited
Biological Process (BP) inner ear development 0.004523 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.009672 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.2219 Highly Informative Inherited
Molecular Function (MF) binding 5.512e-06 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.0001036 Least Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 7.414e-06 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 2.18e-05 Moderately Informative Direct
Molecular Function (MF) peptidase activity 0 Informative Direct
Molecular Function (MF) peptidase regulator activity 2.481e-13 Informative Direct
Molecular Function (MF) receptor activity 3.609e-12 Informative Direct
Molecular Function (MF) molecular transducer activity 1.358e-08 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1.652e-07 Informative Direct
Molecular Function (MF) kinase activity 7.75e-07 Informative Direct
Molecular Function (MF) enzyme activator activity 4.943e-05 Informative Direct
Molecular Function (MF) receptor binding 0.0001962 Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.000851 Informative Direct
Molecular Function (MF) monosaccharide binding 0 Highly Informative Direct
Molecular Function (MF) protein kinase activity 2.313e-09 Highly Informative Direct
Molecular Function (MF) endopeptidase activity 5.675e-05 Highly Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.9028 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane part 1.173e-13 Moderately Informative Direct
Cellular Component (CC) cell projection 0.002885 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 0.003768 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.001692 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 0.5714 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.01057 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.5535 Moderately Informative Inherited
Cellular Component (CC) extracellular matrix 1.418e-14 Informative Direct
Cellular Component (CC) integral to membrane 1.498e-07 Informative Direct
Cellular Component (CC) nuclear envelope 5.474e-07 Informative Direct
Cellular Component (CC) cell surface 1.741e-06 Informative Direct
Cellular Component (CC) neuron projection 0.0001881 Informative Direct
Cellular Component (CC) extracellular matrix part 1.573e-12 Highly Informative Direct
Cellular Component (CC) proteinaceous extracellular matrix 0.03689 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Serine endopeptidases1.313e-13Moderately InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase1.212e-12InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0.0002463InformativeDirect
Enzyme Commission (EC)Plasmin0Highly InformativeDirect
Enzyme Commission (EC)T-plasminogen activator2.098e-15Highly InformativeDirect
Enzyme Commission (EC)Gelatinase B1.879e-10Highly InformativeDirect
Enzyme Commission (EC)Gelatinase A1.879e-10Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.02607Least InformativeInherited
Disease Ontology (DO)nervous system disease0.0323Least InformativeInherited
Disease Ontology (DO)artery disease8.013e-05Moderately InformativeDirect
Disease Ontology (DO)kidney disease0.0001403Moderately InformativeDirect
Disease Ontology (DO)lung disease0.0009217Moderately InformativeDirect
Disease Ontology (DO)syndrome0.0009343Moderately InformativeDirect
Disease Ontology (DO)skin disease0.001382Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.007224Moderately InformativeInherited
Disease Ontology (DO)hematologic cancer0.04757Moderately InformativeInherited
Disease Ontology (DO)musculoskeletal system disease0.05356Moderately InformativeInherited
Disease Ontology (DO)nervous system cancer0.1879Moderately InformativeInherited
Disease Ontology (DO)sensory system disease0.35Moderately InformativeInherited
Disease Ontology (DO)brain disease0.4897Moderately InformativeInherited
Disease Ontology (DO)laryngeal carcinoma9.085e-05InformativeDirect
Disease Ontology (DO)myopia9.417e-05InformativeDirect
Disease Ontology (DO)liver disease0.0006641InformativeDirect
Disease Ontology (DO)lung carcinoma0.0007635InformativeDirect
Disease Ontology (DO)female reproductive system disease0.0007663InformativeDirect
Disease Ontology (DO)meningioma0.0008424InformativeDirect
Disease Ontology (DO)leukodystrophy0.0009828InformativeDirect
Disease Ontology (DO)auditory system disease0.00129InformativeInherited
Disease Ontology (DO)coronary artery disease0.003137InformativeInherited
Disease Ontology (DO)lymphoma0.007634InformativeInherited
Disease Ontology (DO)endocrine gland cancer0.00932InformativeInherited
Disease Ontology (DO)muscular disease0.1514InformativeInherited
Disease Ontology (DO)connective tissue cancer0.4351InformativeInherited
Disease Ontology (DO)meningitis3.84e-05Highly InformativeDirect
Disease Ontology (DO)Hodgkin's lymphoma6.559e-05Highly InformativeDirect
Disease Ontology (DO)osteosarcoma6.853e-05Highly InformativeDirect
Disease Ontology (DO)dermatomyositis0.0001169Highly InformativeDirect
Disease Ontology (DO)endometriosis0.0002075Highly InformativeDirect
Disease Ontology (DO)cerebrovascular disease0.001646Highly InformativeInherited
Disease Ontology (DO)keratosis0.02299Highly InformativeInherited
Disease Ontology (DO)interstitial lung disease0.1139Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of head and neck0.7344Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the mouth0.4381Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the oral cavity0.3098InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gingiva0.0001812Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.02622Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.1669Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.2488Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.6133Least InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.006695Moderately InformativeInherited
Mammalian Phenotype (MP)digestive/alimentary phenotype0.01997Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.05813Moderately InformativeInherited
Mammalian Phenotype (MP)tumorigenesis0.09388Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.09919Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.194Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.2272Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.3174Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.417Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.7103Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lung morphology0.0002041InformativeDirect
Mammalian Phenotype (MP)abnormal uvea morphology0.0002132InformativeDirect
Mammalian Phenotype (MP)abnormal skeleton physiology0.001532InformativeInherited
Mammalian Phenotype (MP)abnormal limb morphology0.001626InformativeInherited
Mammalian Phenotype (MP)abnormal response to injury0.001932InformativeInherited
Mammalian Phenotype (MP)pathological neovascularization0.002315InformativeInherited
Mammalian Phenotype (MP)abnormal respiratory function0.007434InformativeInherited
Mammalian Phenotype (MP)arteriosclerosis0.009762InformativeInherited
Mammalian Phenotype (MP)abnormal intestine morphology0.09434InformativeInherited
Mammalian Phenotype (MP)decreased susceptibility to induced choroidal neovascularization1.253e-10Highly InformativeDirect
Mammalian Phenotype (MP)arthritis6e-05Highly InformativeDirect
Mammalian Phenotype (MP)altered response to CNS ischemic injury0.0002552Highly InformativeDirect
Mammalian Phenotype (MP)decreased tumor growth/size0.000344Highly InformativeDirect
Mammalian Phenotype (MP)abnormal breathing pattern0.003519Highly InformativeInherited
Mammalian Phenotype (MP)abnormal digit morphology0.00545Highly InformativeInherited
Mammalian Phenotype (MP)altered metastatic potential0.1291Highly InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to atherosclerosis0.351Highly InformativeInherited

Document: MP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.1737Least InformativeInherited
Xenopus ANatomical entity (XAN)portion of tissue0.4779Least InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.8607Moderately InformativeInherited
Xenopus ANatomical entity (XAN)notochord0.0008474InformativeDirect
Xenopus ANatomical entity (XAN)neural plate0.02502InformativeInherited
Xenopus ANatomical entity (XAN)mesenchyme0.0003889Highly InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups0.9283Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases8.149e-14InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases6.143e-11InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0.0002328InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase9.422e-13Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processHemostasis0InformativeDirect
Biological processAngiogenesis1.001e-14InformativeDirect
Biological processEndocytosis1.508e-11InformativeDirect
Biological processWnt signaling pathway7.227e-09InformativeDirect
Biological processCell adhesion1.027e-05InformativeDirect
Biological processAcute phase0Highly InformativeDirect
Biological processBlood coagulation0Highly InformativeDirect
Biological processFertilization0Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentExtracellular matrix2.581e-06InformativeDirect
DomainRepeat0Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainEGF-like domain0InformativeDirect
DomainKringle0Highly InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionHeparin-binding8.421e-14InformativeDirect
Molecular functionLectin1.329e-09InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationReceptor7.983e-12Moderately InformativeDirect
Post-translational modificationKinase0.3926Moderately InformativeInherited
Post-translational modificationSerine protease0InformativeDirect
Post-translational modificationGrowth factor1.287e-07InformativeDirect
Post-translational modificationTyrosine-protein kinase4.115e-10Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues1.686e-12Moderately InformativeDirect
Post-translational modificationZymogen0InformativeDirect
Post-translational modificationPyrrolidone carboxylic acid4.879e-07InformativeDirect
Post-translational modificationSulfation1.706e-05InformativeDirect
Post-translational modificationGamma-carboxyglutamic acid2.921e-08Highly InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR013806 SSF57440 Protein matches
Abstract

This entry represents proteins displaying a Kringle-like structure, which consists of a nearly all-beta, disulphide-rich fold. Proteins displaying this fold include both Kringle modules as well as fibronectin type II modules, the latter displaying a shorter two-disulphide version of the Kringle module.

Kringle modules occur in blood clotting and fibrinolytic proteins, such as plasminogen, prothrombin, meizothrombin, and urokinase-type plasminogen activator, as well as in apolipoprotein and hepatocyte growth factor. Kringle domains are believed to play a role in binding mediators (e.g., membranes, other proteins or phospholipids), and in the regulation of proteolytic activity [PubMed6373375, PubMed2157850].

Fibronectin type II modules occur in fibronectin, as well as in gelatinase A (MMP-2), gelatinase B (MMP-9), and the collagen-binding domain of PDC-109. Fibronectin is a multi-domain glycoprotein, found in a soluble form in plasma, and in an insoluble form in loose connective tissue and basement membranes, that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin [PubMed3780752]. Fibronectins are involved in a number of important functions e.g., wound healing; cell adhesion; blood coagulation; cell differentiation and migration; maintenance of the cellular cytoskeleton; and tumour metastasis. Gelatinases A and B are members of the matrix metalloproteinase family that act as neutral proteinases in the breakdown and remodelling of the extracellular matrix. These gelatinases play important roles in the pathogenesis of inflammation, infection and in neoplastic diseases [PubMed16019990]. In gelatinase A, the three fibronectin-like modules are inserted within a catalytic domain, these modules acting to target the enzyme to matrix macromolecules [PubMed16085117].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 24 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Kringle-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 24 hidden Markov models representing the Kringle-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]