SUPERFAMILY 1.75 HMM library and genome assignments server


LDL receptor-like module superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   LDL receptor-like module [ 57423]
Superfamily:   LDL receptor-like module [ 57424]
Families:   LDL receptor-like module [ 57425] (6)


Superfamily statistics
Genomes (186) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 28,305 24,938 26
Proteins 6,731 6,060 18


Functional annotation
General category Processes_IC
Detailed category Transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) response to stimulus 1.382e-07 Least Informative Direct
Biological Process (BP) protein metabolic process 6.999e-06 Least Informative Direct
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.2779 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.2192 Least Informative Inherited
Biological Process (BP) regulation of protein metabolic process 5.055e-09 Moderately Informative Direct
Biological Process (BP) cell differentiation 7.844e-08 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 8.948e-07 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 4.224e-05 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 8.262e-05 Moderately Informative Direct
Biological Process (BP) signal transduction 0.0002593 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0.0002921 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.6787 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.4019 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.635 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.04827 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.8805 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.2823 Moderately Informative Inherited
Biological Process (BP) macromolecule catabolic process 0.446 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.003318 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.05227 Moderately Informative Inherited
Biological Process (BP) organ development 0.2029 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 0.9018 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.1523 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.9674 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.9323 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.4101 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.3861 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.8793 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) system process 0.9905 Moderately Informative Inherited
Biological Process (BP) reproduction 0.0241 Moderately Informative Inherited
Biological Process (BP) immune system process 0.4624 Moderately Informative Inherited
Biological Process (BP) vesicle-mediated transport 0 Informative Direct
Biological Process (BP) locomotion 4.094e-12 Informative Direct
Biological Process (BP) steroid metabolic process 1.217e-10 Informative Direct
Biological Process (BP) generation of neurons 4.949e-10 Informative Direct
Biological Process (BP) cellular component movement 6.16e-10 Informative Direct
Biological Process (BP) single-organism behavior 3.972e-09 Informative Direct
Biological Process (BP) proteolysis 1.311e-07 Informative Direct
Biological Process (BP) regulation of protein phosphorylation 1.432e-07 Informative Direct
Biological Process (BP) alcohol metabolic process 7.469e-07 Informative Direct
Biological Process (BP) regulation of immune effector process 8.622e-06 Informative Direct
Biological Process (BP) vitamin metabolic process 3.293e-05 Informative Direct
Biological Process (BP) regulation of locomotion 6.949e-05 Informative Direct
Biological Process (BP) cell projection organization 0.0001003 Informative Direct
Biological Process (BP) embryo development ending in birth or egg hatching 0.0002731 Informative Direct
Biological Process (BP) lipid localization 0.000367 Informative Direct
Biological Process (BP) regulation of nervous system development 0.0006893 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.0008079 Informative Direct
Biological Process (BP) negative regulation of signaling 0.0008895 Informative Direct
Biological Process (BP) positive regulation of signal transduction 0.7988 Informative Inherited
Biological Process (BP) positive regulation of cell proliferation 0.5024 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.4682 Informative Inherited
Biological Process (BP) membrane organization 0.2633 Informative Inherited
Biological Process (BP) muscle tissue development 0.001208 Informative Inherited
Biological Process (BP) sensory organ development 0.5537 Informative Inherited
Biological Process (BP) cardiovascular system development 0.1625 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.9111 Informative Inherited
Biological Process (BP) organ morphogenesis 0.01892 Informative Inherited
Biological Process (BP) protein complex assembly 0.2628 Informative Inherited
Biological Process (BP) muscle structure development 0.0212 Informative Inherited
Biological Process (BP) cell-cell signaling 0.75 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.001793 Informative Inherited
Biological Process (BP) defense response 0.06542 Informative Inherited
Biological Process (BP) single organism reproductive process 0.4912 Informative Inherited
Biological Process (BP) protein catabolic process 0.5752 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.2836 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.06996 Informative Inherited
Biological Process (BP) growth 0.001687 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 0.003653 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.01821 Informative Inherited
Biological Process (BP) gland development 0.1649 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.00119 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.04751 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.8365 Informative Inherited
Biological Process (BP) localization of cell 0.001408 Informative Inherited
Biological Process (BP) central nervous system development 0.0386 Informative Inherited
Biological Process (BP) isoprenoid metabolic process 0.008764 Informative Inherited
Biological Process (BP) regulation of cell development 0.01614 Informative Inherited
Biological Process (BP) response to light stimulus 0.1175 Informative Inherited
Biological Process (BP) reproductive structure development 0.9879 Informative Inherited
Biological Process (BP) response to nutrient levels 0.1404 Informative Inherited
Biological Process (BP) immune response 0.293 Informative Inherited
Biological Process (BP) immune effector process 0.01647 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.6165 Informative Inherited
Biological Process (BP) regulation of immune response 0.5702 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.02318 Informative Inherited
Biological Process (BP) regulation of defense response 0.02432 Informative Inherited
Biological Process (BP) regulation of protein processing 0 Highly Informative Direct
Biological Process (BP) organic hydroxy compound transport 1.532e-12 Highly Informative Direct
Biological Process (BP) regulation of humoral immune response 2.963e-12 Highly Informative Direct
Biological Process (BP) response to drug 3.216e-10 Highly Informative Direct
Biological Process (BP) sterol metabolic process 3.459e-09 Highly Informative Direct
Biological Process (BP) mammary gland epithelium development 1.398e-07 Highly Informative Direct
Biological Process (BP) lipoprotein metabolic process 6.965e-07 Highly Informative Direct
Biological Process (BP) telencephalon development 8.836e-07 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 1.421e-06 Highly Informative Direct
Biological Process (BP) retinoid metabolic process 2.72e-06 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 3.077e-06 Highly Informative Direct
Biological Process (BP) regulation of inflammatory response 5.664e-06 Highly Informative Direct
Biological Process (BP) morphogenesis of a branching epithelium 8.989e-06 Highly Informative Direct
Biological Process (BP) cell junction organization 1.231e-05 Highly Informative Direct
Biological Process (BP) protein activation cascade 2.022e-05 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 2.736e-05 Highly Informative Direct
Biological Process (BP) connective tissue development 3.426e-05 Highly Informative Direct
Biological Process (BP) neuron projection development 9.676e-05 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0.0001691 Highly Informative Direct
Biological Process (BP) innate immune response 0.000222 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.0002402 Highly Informative Direct
Biological Process (BP) protein tetramerization 0.0002502 Highly Informative Direct
Biological Process (BP) muscle organ development 0.0003652 Highly Informative Direct
Biological Process (BP) development of primary male sexual characteristics 0.0005679 Highly Informative Direct
Biological Process (BP) humoral immune response 0.0008967 Highly Informative Direct
Biological Process (BP) retina development in camera-type eye 0.001253 Highly Informative Inherited
Biological Process (BP) epithelial tube morphogenesis 0.1525 Highly Informative Inherited
Biological Process (BP) cell fate commitment 0.6997 Highly Informative Inherited
Biological Process (BP) mesenchyme development 0.1272 Highly Informative Inherited
Biological Process (BP) phagocytosis 0.1532 Highly Informative Inherited
Biological Process (BP) developmental growth 0.003472 Highly Informative Inherited
Biological Process (BP) limb morphogenesis 0.002817 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.8123 Highly Informative Inherited
Biological Process (BP) detection of light stimulus 0.003225 Highly Informative Inherited
Biological Process (BP) gonad development 0.2091 Highly Informative Inherited
Biological Process (BP) cell part morphogenesis 0.03826 Highly Informative Inherited
Biological Process (BP) chemotaxis 0.001622 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.0123 Highly Informative Inherited
Biological Process (BP) muscle fiber development 0.02405 Highly Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 0.143 Highly Informative Inherited
Biological Process (BP) activation of immune response 0.001655 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0.0003435 Least Informative Direct
Molecular Function (MF) binding 0.009094 Least Informative Inherited
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) peptidase activity 3.054e-15 Informative Direct
Molecular Function (MF) molecular transducer activity 1.554e-08 Informative Direct
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 7.394e-06 Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.0002623 Informative Direct
Molecular Function (MF) receptor binding 0.04365 Informative Inherited
Molecular Function (MF) deacetylase activity 1.329e-06 Highly Informative Direct
Molecular Function (MF) G-protein coupled receptor activity 0.4741 Highly Informative Inherited
Molecular Function (MF) endopeptidase activity 0.06215 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.8755 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.05727 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) extracellular region part 1.521e-15 Moderately Informative Direct
Cellular Component (CC) plasma membrane part 2.364e-06 Moderately Informative Direct
Cellular Component (CC) vesicle 0.0001111 Moderately Informative Direct
Cellular Component (CC) cell projection 0.0004322 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 0.2082 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.1169 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.6866 Moderately Informative Inherited
Cellular Component (CC) endosome 0 Informative Direct
Cellular Component (CC) extracellular matrix 0 Informative Direct
Cellular Component (CC) lytic vacuole 1.353e-08 Informative Direct
Cellular Component (CC) integral to membrane 7.759e-08 Informative Direct
Cellular Component (CC) synapse part 3.075e-07 Informative Direct
Cellular Component (CC) cell surface 8.471e-07 Informative Direct
Cellular Component (CC) Golgi apparatus 1.794e-05 Informative Direct
Cellular Component (CC) vacuolar part 0.0002153 Informative Direct
Cellular Component (CC) extracellular matrix part 0 Highly Informative Direct
Cellular Component (CC) lysosome 1.189e-09 Highly Informative Direct
Cellular Component (CC) proteinaceous extracellular matrix 2.196e-09 Highly Informative Direct
Cellular Component (CC) lipid particle 3.346e-08 Highly Informative Direct
Cellular Component (CC) cell body 6.417e-07 Highly Informative Direct
Cellular Component (CC) receptor complex 3.424e-05 Highly Informative Direct
Cellular Component (CC) brush border 3.99e-05 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 0.000663 Highly Informative Direct
Cellular Component (CC) vacuolar membrane 0.0007771 Highly Informative Direct
Cellular Component (CC) membrane raft 0.001482 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the immune system0.6646Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of humoral immunity0.03417InformativeInherited
Phenotypic Abnormality (PA)Recurrent infections0.3528InformativeInherited
Phenotypic Abnormality (PA)Abnormality of complement system1.667e-05Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.5062Least InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.02646Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.1084Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal coat appearance0.0009972InformativeDirect
Mammalian Phenotype (MP)abnormal limb morphology0.7272InformativeInherited
Mammalian Phenotype (MP)abnormal eye pigmentation0.01057Highly InformativeInherited
Mammalian Phenotype (MP)abnormal digit morphology0.03466Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)locomotion variant0.5864Moderately InformativeInherited
Worm Phenotype (WP)activity level variant0.01144InformativeInherited
Worm Phenotype (WP)paralyzed0.000304Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)alimentary system0.0229Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.7743Least InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.2934Moderately InformativeInherited
Xenopus ANatomical entity (XAN)hindgut7.181e-06Highly InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases1.803e-07Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0InformativeDirect
Enzyme Commission (EC)Enteropeptidase4.111e-11Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.01109Least InformativeInherited
Biological processLipid metabolism2.38e-07Moderately InformativeDirect
Biological processCytolysis0InformativeDirect
Biological processEndocytosis0InformativeDirect
Biological processInnate immunity0InformativeDirect
Biological processLipid transport0InformativeDirect
Biological processSteroid metabolism0InformativeDirect
Biological processWnt signaling pathway2.697e-10InformativeDirect
Biological processCell adhesion8.674e-08InformativeDirect
Biological processCholesterol metabolism0Highly InformativeDirect
Biological processComplement pathway0Highly InformativeDirect
Biological processComplement alternate pathway1.396e-15Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentEndosome3.377e-07Moderately InformativeDirect
Cellular componentGolgi apparatus9.038e-05Moderately InformativeDirect
Cellular componentLysosome3.024e-06InformativeDirect
Cellular componentCoated pit0Highly InformativeDirect
DiseaseDisease mutation7.007e-07Least InformativeDirect
DomainRepeat0Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
DomainEGF-like domain0InformativeDirect
DomainSignal-anchor6.418e-08InformativeDirect
DomainSushi4.15e-10Highly InformativeDirect
DomainTransmembrane beta strand4.208e-05Highly InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Post-translational modificationHydrolase0.04233Least InformativeInherited
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationDevelopmental protein3.254e-06Moderately InformativeDirect
Post-translational modificationSerine protease0InformativeDirect
Post-translational modificationTransducer2.869e-05InformativeDirect
Post-translational modificationG-protein coupled receptor9.692e-06Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationZymogen0.0001018InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)glycan metabolism0Moderately InformativeDirect
UniPathway (UP)N-glycan metabolism0Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR002172 SSF57424 Protein matches
Abstract

Low density lipoprotein (LDL) is the major cholesterol-carrying lipoprotein of plasma. The receptor protein binds LDL and transports it into cells by endocytosis. In order to be internalised, the receptor-ligand complex must first cluster into clathrin-coated pits. Seven successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein [PubMed6091915].

The LDL-receptor class A domain contains 6 disulphide-bound cysteines [PubMed7548065] and a highly conserved cluster of negatively charged amino acids, of which many are clustered on one face of the module [PubMed7603991]. A schematic representation of this domain is shown here:

   +---------------------+        +--------------------------------+
   |                     |        |                                |
  -CxxxxxxxxxxxxCxxxxxxxxCxxxxxxxxCxxxxxxxxxxCxxxxxxxxxxxxxxxxxxxxxC-
                |                            |
                +----------------------------+

'C': conserved cysteine involved in a disulphide bond.
'x': any residue.

In LDL-receptors the class A domains form the binding site for LDL [PubMed6091915] and calcium [PubMed3320043]. The acidic residues between the fourth and sixth cysteines are important for high-affinity binding of positively charged sequences in LDLR's ligands [PubMed3283935]. The repeat has been shown [PubMed7603991] to consist of a beta-hairpin structure followed by a series of beta turns. In the absence of calcium, LDL-A domains are unstructured; the bound calcium ion imparts structural integrity.

Following these repeats is a 350 residue domain that resembles part of the epidermal growth factor (EGF) precursor [PubMed6327078, PubMed6091915].

Similar domains have been found (see references in [PubMed7603991]) in several extracellular and membrane proteins (see examples).

Numerous familial hypercholestorolemia mutations of the LDL receptor alter the calcium coordinating residue of LDL-A domains or other crucial scaffolding residues.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 15 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a LDL receptor-like module domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 15 hidden Markov models representing the LDL receptor-like module superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]