SUPERFAMILY 1.75 HMM library and genome assignments server


Hairpin loop containing domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Hairpin loop containing domain-like [ 57413]
Superfamily:   Hairpin loop containing domain-like [ 57414] (3)
Families:   Hairpin loop containing domain [ 57415]
  Anti-platelet protein [ 64556]
  Pan module (APPLE domain) [ 82901]


Superfamily statistics
Genomes (322) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 3,069 3,366 8
Proteins 2,044 2,259 8


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 7.021e-09 Least Informative Direct
Biological Process (BP) developmental process 7.388e-11 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.0004268 Least Informative Direct
Biological Process (BP) localization 0.3938 Least Informative Inherited
Biological Process (BP) response to stimulus 0.973 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.1221 Least Informative Inherited
Biological Process (BP) single-organism developmental process 0.0002773 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 4.359e-08 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 5.343e-08 Moderately Informative Direct
Biological Process (BP) nervous system development 0.5404 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.001696 Moderately Informative Inherited
Biological Process (BP) system process 0.6058 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.01681 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.1605 Moderately Informative Inherited
Biological Process (BP) cellular component movement 1.964e-06 Informative Direct
Biological Process (BP) response to wounding 0.0001611 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 1.018e-12 Informative Direct
Biological Process (BP) cellular component morphogenesis 1.42e-07 Informative Direct
Biological Process (BP) generation of neurons 0.0003921 Informative Direct
Biological Process (BP) localization of cell 3.95e-05 Informative Direct
Biological Process (BP) actin filament-based process 0.003009 Informative Inherited
Biological Process (BP) cell projection organization 0.03583 Informative Inherited
Biological Process (BP) epithelium development 0.3299 Informative Inherited
Biological Process (BP) epithelial cell development 1.919e-05 Highly Informative Direct
Biological Process (BP) sensory perception 1.254e-05 Highly Informative Direct
Biological Process (BP) actin filament-based movement 2.726e-05 Highly Informative Direct
Biological Process (BP) wound healing 3.344e-06 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in neuron differentiation 0.7548 Highly Informative Inherited
Biological Process (BP) cell projection morphogenesis 1 Highly Informative Inherited
Cellular Component (CC) extracellular matrix 3.007e-06 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0Moderately InformativeDirect
Enzyme Commission (EC)Plasmin0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0Least InformativeDirect
Disease Ontology (DO)neurodegenerative disease0Moderately InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.03399Least InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.01089Moderately InformativeInherited
Mammalian Phenotype (MP)hemorrhage0.000716InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect

Document: FA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases1.641e-07Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processHemostasis0InformativeDirect
Biological processBlood coagulation0Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
DomainSignal0Least InformativeDirect
DomainRepeat7.236e-09Least InformativeDirect
DomainKringle0Highly InformativeDirect
Post-translational modificationHydrolase0.001052Least InformativeInherited
Post-translational modificationProtease1.697e-12Moderately InformativeDirect
Post-translational modificationGrowth factor8.314e-12InformativeDirect
Post-translational modificationSerine protease5.433e-07InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationGlycoprotein2.603e-05Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues4.301e-05Moderately InformativeDirect
Post-translational modificationZymogen1.583e-08InformativeDirect
Post-translational modificationPyrrolidone carboxylic acid1.607e-07InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Hairpin loop containing domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the Hairpin loop containing domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]