SUPERFAMILY 1.75 HMM library and genome assignments server

Hairpin loop containing domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Hairpin loop containing domain-like [ 57413]
Superfamily:   Hairpin loop containing domain-like [ 57414] (3)
Families:   Hairpin loop containing domain [ 57415]
  Anti-platelet protein [ 64556]
  Pan module (APPLE domain) [ 82901]


Superfamily statistics
Genomes (323) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 3,124 3,366 8
Proteins 2,092 2,259 8


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0.000000002689 Least Informative Direct
Biological Process (BP) developmental process 0.00000000007097 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.0005878 Least Informative Direct
Biological Process (BP) localization 0.4257 Least Informative Inherited
Biological Process (BP) response to stimulus 0.9776 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.4621 Least Informative Inherited
Biological Process (BP) regulation of developmental process 0.00000005035 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.00000002925 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.000008509 Moderately Informative Direct
Biological Process (BP) nervous system development 0.566 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.1609 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.3947 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.002256 Moderately Informative Inherited
Biological Process (BP) tissue development 0.017 Moderately Informative Inherited
Biological Process (BP) cellular component movement 0.0000004827 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.0000000000009526 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.0000007101 Informative Direct
Biological Process (BP) generation of neurons 0.0004025 Informative Direct
Biological Process (BP) neurological system process 0.0002426 Informative Direct
Biological Process (BP) localization of cell 0.00004137 Informative Direct
Biological Process (BP) negative regulation of cell death 0.0002199 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.001471 Informative Inherited
Biological Process (BP) cell projection organization 0.01988 Informative Inherited
Biological Process (BP) actin filament-based process 0.001648 Informative Inherited
Biological Process (BP) epithelium development 0.5017 Informative Inherited
Biological Process (BP) epithelial cell development 0.00002832 Highly Informative Direct
Biological Process (BP) sensory perception 0.00001279 Highly Informative Direct
Biological Process (BP) actin filament-based movement 0.00002694 Highly Informative Direct
Biological Process (BP) neuron projection development 0.0004081 Highly Informative Direct
Biological Process (BP) wound healing 0.000003463 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0.01863 Highly Informative Inherited
Biological Process (BP) cell projection morphogenesis 1 Highly Informative Inherited
Cellular Component (CC) extracellular matrix 0.000002672 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0Moderately InformativeDirect
Enzyme Commission (EC)Plasmin0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0Least InformativeDirect
Disease Ontology (DO)neurodegenerative disease0Moderately InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.03481Least InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.01129Moderately InformativeInherited
Mammalian Phenotype (MP)hemorrhage0.0007431InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect

Document: FA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.0000001715Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processHemostasis0InformativeDirect
Biological processBlood coagulation0Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
DomainSignal0Least InformativeDirect
DomainRepeat0.00000000743Least InformativeDirect
DomainKringle0Highly InformativeDirect
Post-translational modificationHydrolase0.001081Least InformativeInherited
Post-translational modificationProtease0.000000000001686Moderately InformativeDirect
Post-translational modificationGrowth factor0.000000000008264InformativeDirect
Post-translational modificationSerine protease0.0000005433InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationGlycoprotein0.00002697Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues0.00004285Moderately InformativeDirect
Post-translational modificationZymogen0.00000001559InformativeDirect
Post-translational modificationPyrrolidone carboxylic acid0.0000001589InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Hairpin loop containing domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the Hairpin loop containing domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]