SUPERFAMILY 1.75 HMM library and genome assignments server

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Hairpin loop containing domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Hairpin loop containing domain-like [ 57413]
Superfamily:   Hairpin loop containing domain-like [ 57414] (3)
Families:   Hairpin loop containing domain [ 57415]
  Anti-platelet protein [ 64556]
  Pan module (APPLE domain) [ 82901]


Superfamily statistics
Genomes (322) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 3,069 3,366 8
Proteins 2,044 2,259 8


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0.000000006967 Least Informative Direct
Biological Process (BP) developmental process 0.00000000007262 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.0004526 Least Informative Direct
Biological Process (BP) localization 0.3999 Least Informative Inherited
Biological Process (BP) response to stimulus 0.9768 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.1232 Least Informative Inherited
Biological Process (BP) regulation of developmental process 0.00000004917 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.000000061 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.000009869 Moderately Informative Direct
Biological Process (BP) nervous system development 0.5467 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.001717 Moderately Informative Inherited
Biological Process (BP) system process 0.6109 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.01688 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.1612 Moderately Informative Inherited
Biological Process (BP) cellular component movement 0.000001875 Informative Direct
Biological Process (BP) response to wounding 0.0001645 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.000000000001122 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.0000001336 Informative Direct
Biological Process (BP) generation of neurons 0.0003926 Informative Direct
Biological Process (BP) localization of cell 0.00004016 Informative Direct
Biological Process (BP) actin filament-based process 0.002992 Informative Inherited
Biological Process (BP) cell projection organization 0.03548 Informative Inherited
Biological Process (BP) epithelium development 0.333 Informative Inherited
Biological Process (BP) epithelial cell development 0.00002023 Highly Informative Direct
Biological Process (BP) sensory perception 0.00001261 Highly Informative Direct
Biological Process (BP) actin filament-based movement 0.00002735 Highly Informative Direct
Biological Process (BP) neuron projection development 0.0003992 Highly Informative Direct
Biological Process (BP) wound healing 0.000003509 Highly Informative Direct
Biological Process (BP) cell part morphogenesis 1 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.02128 Highly Informative Inherited
Cellular Component (CC) extracellular matrix 0.000003036 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0Moderately InformativeDirect
Enzyme Commission (EC)Plasmin0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0Least InformativeDirect
Disease Ontology (DO)neurodegenerative disease0Moderately InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.03481Least InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.01129Moderately InformativeInherited
Mammalian Phenotype (MP)hemorrhage0.0007431InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect

Document: FA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.0000001715Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processHemostasis0InformativeDirect
Biological processBlood coagulation0Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
DomainSignal0Least InformativeDirect
DomainRepeat0.00000000743Least InformativeDirect
DomainKringle0Highly InformativeDirect
Post-translational modificationHydrolase0.001081Least InformativeInherited
Post-translational modificationProtease0.000000000001686Moderately InformativeDirect
Post-translational modificationGrowth factor0.000000000008264InformativeDirect
Post-translational modificationSerine protease0.0000005433InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationGlycoprotein0.00002697Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues0.00004285Moderately InformativeDirect
Post-translational modificationZymogen0.00000001559InformativeDirect
Post-translational modificationPyrrolidone carboxylic acid0.0000001589InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Hairpin loop containing domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the Hairpin loop containing domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]