SUPERFAMILY 1.75 HMM library and genome assignments server

BPTI-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   BPTI-like [ 57361]
Superfamily:   BPTI-like [ 57362] (3)
Families:   Small Kunitz-type inhibitors & BPTI-like toxins [ 57363] (12)
  Soft tick anticoagulant proteins [ 57386] (2)
  Tick tryptase inhibitor-like [ 161132]


Superfamily statistics
Genomes (155) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 6,091 9,169 59
Proteins 3,022 5,015 57


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of metabolic process0.000000015770.000003923Least InformativeDirect
Biological Process (BP)response to stimulus0.067540.00000587Least InformativeInherited
Biological Process (BP)regulation of cellular process0.0000071160.007418Least InformativeInherited
Biological Process (BP)regulation of catalytic activity0.00000000000019030Moderately InformativeDirect
Biological Process (BP)negative regulation of metabolic process0.0000000000002940.0005505Moderately InformativeDirect
Biological Process (BP)regulation of protein metabolic process0.00000000000033290Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process0.00000000028830.0005185Moderately InformativeDirect
Biological Process (BP)multi-organism process0.0000047730.0000000001311Moderately InformativeDirect
Biological Process (BP)regulation of gene expression0.000000000023250.1114Moderately InformativeInherited
Biological Process (BP)regulation of peptidase activity00InformativeDirect
Biological Process (BP)negative regulation of catalytic activity00.000000004056InformativeDirect
Biological Process (BP)negative regulation of cellular protein metabolic process00.000000526InformativeDirect
Biological Process (BP)negative regulation of protein processing00.0000006779InformativeDirect
Biological Process (BP)multi-organism behavior0.00000000042270Highly InformativeDirect
Molecular Function (MF)enzyme regulator activity00.00000000000000467Moderately InformativeDirect
Molecular Function (MF)peptidase regulator activity00InformativeDirect
Molecular Function (MF)enzyme inhibitor activity00.000000001298InformativeDirect
Molecular Function (MF)serine-type endopeptidase inhibitor activity00.00001108Highly InformativeDirect
Cellular Component (CC)extracellular region part00Moderately InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of metabolic process 0.000003923 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.0000000005967 Least Informative Direct
Biological Process (BP) response to stimulus 0.00000587 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.000003922 Least Informative Direct
Biological Process (BP) positive regulation of biological process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.007418 Least Informative Inherited
Biological Process (BP) developmental process 0.002188 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.04516 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.1065 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.6733 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.3394 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 0.6947 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.1229 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.3115 Least Informative Inherited
Biological Process (BP) regulation of catalytic activity 0 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0.0005505 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.0005185 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.0000000001311 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0.00000002871 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.0000002559 Moderately Informative Direct
Biological Process (BP) reproductive process 0.000000685 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.00004233 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 0.0002097 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of phosphorus metabolic process 0.009056 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.003702 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.03249 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.002168 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.05092 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.001048 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.4521 Moderately Informative Inherited
Biological Process (BP) gene expression 0.003798 Moderately Informative Inherited
Biological Process (BP) organ development 0.9684 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.005029 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.06559 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.01158 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.3541 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.02359 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.1114 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of peptidase activity 0 Informative Direct
Biological Process (BP) negative regulation of catalytic activity 0.000000004056 Informative Direct
Biological Process (BP) negative regulation of cellular protein metabolic process 0.000000526 Informative Direct
Biological Process (BP) negative regulation of protein processing 0.0000006779 Informative Direct
Biological Process (BP) neurological system process 0 Informative Direct
Biological Process (BP) single-organism behavior 0 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0.00000000000002422 Informative Direct
Biological Process (BP) cation homeostasis 0.0000000000000567 Informative Direct
Biological Process (BP) regulation of mitotic cell cycle 0.0000000005656 Informative Direct
Biological Process (BP) response to light stimulus 0.000000003091 Informative Direct
Biological Process (BP) microtubule-based process 0.0000000528 Informative Direct
Biological Process (BP) cell projection organization 0.0000003656 Informative Direct
Biological Process (BP) RNA processing 0.0000005306 Informative Direct
Biological Process (BP) locomotion 0.00000106 Informative Direct
Biological Process (BP) regulation of growth 0.000001185 Informative Direct
Biological Process (BP) cellular component movement 0.000001732 Informative Direct
Biological Process (BP) synaptic transmission 0.000002501 Informative Direct
Biological Process (BP) growth 0.000002942 Informative Direct
Biological Process (BP) single-organism intracellular transport 0.000005457 Informative Direct
Biological Process (BP) alcohol metabolic process 0.000006089 Informative Direct
Biological Process (BP) generation of neurons 0.00001074 Informative Direct
Biological Process (BP) posttranscriptional regulation of gene expression 0.00005114 Informative Direct
Biological Process (BP) phosphorylation 0.00005839 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.0002034 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.0002475 Informative Direct
Biological Process (BP) regulation of protein phosphorylation 0.0004304 Informative Direct
Biological Process (BP) regulation of cell cycle process 1 Informative Inherited
Biological Process (BP) apoptotic process 0.002994 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.02677 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.5652 Informative Inherited
Biological Process (BP) regulation of cell development 0.03373 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.2898 Informative Inherited
Biological Process (BP) regulation of transferase activity 0.2856 Informative Inherited
Biological Process (BP) central nervous system development 0.001818 Informative Inherited
Biological Process (BP) sexual reproduction 0.8365 Informative Inherited
Biological Process (BP) multi-organism behavior 0 Highly Informative Direct
Biological Process (BP) cell recognition 0 Highly Informative Direct
Biological Process (BP) regulation of peptidyl-tyrosine phosphorylation 0 Highly Informative Direct
Biological Process (BP) transition metal ion homeostasis 0 Highly Informative Direct
Biological Process (BP) positive regulation of mitotic cell cycle 0 Highly Informative Direct
Biological Process (BP) regulation of multicellular organism growth 0 Highly Informative Direct
Biological Process (BP) cell growth 0.00000000000719 Highly Informative Direct
Biological Process (BP) mRNA processing 0.00000000001687 Highly Informative Direct
Biological Process (BP) microtubule-based movement 0.0000000000324 Highly Informative Direct
Biological Process (BP) chemotaxis 0.00000000004113 Highly Informative Direct
Biological Process (BP) sterol metabolic process 0.00000000006661 Highly Informative Direct
Biological Process (BP) adult behavior 0.000000000691 Highly Informative Direct
Biological Process (BP) neuron projection development 0.000000001348 Highly Informative Direct
Biological Process (BP) developmental growth 0.00000001079 Highly Informative Direct
Biological Process (BP) regulation of translation 0.00000005716 Highly Informative Direct
Biological Process (BP) cell-type specific apoptotic process 0.00000007109 Highly Informative Direct
Biological Process (BP) protein phosphorylation 0.0000009748 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0.00004095 Highly Informative Direct
Biological Process (BP) positive regulation of cell cycle process 0.00006691 Highly Informative Direct
Biological Process (BP) regulation of binding 0.00007754 Highly Informative Direct
Biological Process (BP) cell projection morphogenesis 0.0001704 Highly Informative Direct
Biological Process (BP) negative regulation of nervous system development 0.0002024 Highly Informative Direct
Biological Process (BP) neuromuscular process 0.004618 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.2169 Highly Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 1 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.1362 Highly Informative Inherited
Biological Process (BP) learning or memory 0.3157 Highly Informative Inherited
Molecular Function (MF) binding 0.3152 Least Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.00000000000000467 Moderately Informative Direct
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) peptidase regulator activity 0 Informative Direct
Molecular Function (MF) enzyme inhibitor activity 0.000000001298 Informative Direct
Molecular Function (MF) tetrapyrrole binding 0.00000000346 Informative Direct
Molecular Function (MF) protein complex binding 0.00005466 Informative Direct
Molecular Function (MF) DNA binding 0.0001187 Informative Direct
Molecular Function (MF) protein dimerization activity 0.0008638 Informative Direct
Molecular Function (MF) serine-type endopeptidase inhibitor activity 0.00001108 Highly Informative Direct
Molecular Function (MF) heme binding 0.000000000003314 Highly Informative Direct
Cellular Component (CC) membrane 0.001594 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.9987 Least Informative Inherited
Cellular Component (CC) protein complex 0.2224 Least Informative Inherited
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) intrinsic component of membrane 0.00005052 Moderately Informative Direct
Cellular Component (CC) cell projection 0.0002342 Moderately Informative Direct
Cellular Component (CC) vesicle 0.000659 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.4004 Moderately Informative Inherited
Cellular Component (CC) extracellular matrix 0 Informative Direct
Cellular Component (CC) Golgi apparatus 0.00000007053 Informative Direct
Cellular Component (CC) neuron projection 0.0000002186 Informative Direct
Cellular Component (CC) integral component of membrane 0.0000215 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.05729 Informative Inherited
Cellular Component (CC) synapse 0.001451 Informative Inherited
Cellular Component (CC) extracellular matrix part 0.000000002726 Highly Informative Direct
Cellular Component (CC) sarcolemma 0.000004 Highly Informative Direct
Cellular Component (CC) ciliary part 0.00004364 Highly Informative Direct
Cellular Component (CC) transport vesicle 0.0001312 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.0002179 Highly Informative Direct
Cellular Component (CC) spindle 0.0003912 Highly Informative Direct
Cellular Component (CC) coated vesicle 0.004441 Highly Informative Inherited

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details) Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the abdomen0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0Least InformativeDirect
Phenotypic Abnormality (PA)Abdominal symptom0InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)integument phenotype0.05528Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skin appearance0.0008538InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)pericellular component development variant0Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant0.4184Moderately InformativeInherited
Worm Phenotype (WP)basement membrane remodeling variant0InformativeDirect
Worm Phenotype (WP)somatic gonad development variant0.01106InformativeInherited

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)alimentary system0Least InformativeDirect
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)lung0InformativeDirect
Xenopus ANatomical entity (XAN)adipose tissue0Highly InformativeDirect
Xenopus ANatomical entity (XAN)pancreas0.000486Highly InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0.00007396Moderately InformativeDirect
Biological processHemostasis0.000000000004018InformativeDirect
Biological processCell adhesion0.000000000006398InformativeDirect
Biological processEndocytosis0.00000001136InformativeDirect
Biological processNotch signaling pathway0.0000000000001798Highly InformativeDirect
Biological processBlood coagulation0.000000000003744Highly InformativeDirect
Cellular componentMembrane1Least InformativeInherited
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentExtracellular matrix1InformativeInherited
Cellular componentCoated pit0.000000000002258Highly InformativeDirect
Cellular componentBasement membrane0.0001376Highly InformativeDirect
DomainSignal0Least InformativeDirect
DomainCollagen0.000009145Highly InformativeDirect
Molecular functionHeparin-binding0.000000000131InformativeDirect
Molecular functionCopper0.00000005879InformativeDirect
Molecular functionChromophore0.00000573InformativeDirect
Post-translational modificationProtease inhibitor0InformativeDirect
Post-translational modificationToxin0InformativeDirect
Post-translational modificationMetalloenzyme inhibitor0Highly InformativeDirect
Post-translational modificationIon channel impairing toxin0.0000000003603Highly InformativeDirect
Post-translational modificationNeurotoxin1Highly InformativeInherited
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationGlycoprotein1Least InformativeInherited
Post-translational modificationProteoglycan0.00000002485InformativeDirect
Post-translational modificationPyrrolidone carboxylic acid0.00000008704InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR002223 SSF57362 Protein matches
Abstract

The majority of the sequences having this domain belong to the MEROPS inhibitor family I2, clan IB; the Kunitz/bovine pancreatic trypsin inhibitor family, they inhibit proteases of the S1 family [PubMed14705960] and are restricted to the metazoa with a single exception: Amsacta moorei entomopoxvirus. They are short (~50 residue) alpha/beta proteins with few secondary structures. The fold is constrained by 3 disulphide bonds. The type example for this family is aprotinin (bovine pancreatic trypsin inhibitor) [PubMed1714504] (or basic protease inhibitor), but the family includes numerous other members [PubMed1703675, PubMed1593645, PubMed8159751, PubMed1304909], such as snake venom basic protease; mammalian inter-alpha-trypsin inhibitors; trypstatin, a rat mast cell inhibitor of trypsin; a domain found in an alternatively-spliced form of Alzheimer's amyloid beta-protein; domains at the C-termini of the alpha(1) and alpha(3) chains of type VII and type VI collagens; and tissue factor pathway inhibitor precursor.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 26 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a BPTI-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 26 hidden Markov models representing the BPTI-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]