SUPERFAMILY 1.75 HMM library and genome assignments server

BPTI-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   BPTI-like [ 57361]
Superfamily:   BPTI-like [ 57362] (3)
Families:   Small Kunitz-type inhibitors & BPTI-like toxins [ 57363] (12)
  Soft tick anticoagulant proteins [ 57386] (2)
  Tick tryptase inhibitor-like [ 161132]


Superfamily statistics
Genomes (154) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 6,039 9,169 59
Proteins 2,990 5,015 57


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of metabolic process0.000000010640.00000206Least InformativeDirect
Biological Process (BP)response to stimulus0.068840.000005479Least InformativeInherited
Biological Process (BP)regulation of catalytic activity0.00000000000018720Moderately InformativeDirect
Biological Process (BP)reproduction0.00000011880.000000000001202Moderately InformativeDirect
Biological Process (BP)multi-organism process0.00000084520.00000000000001086Moderately InformativeDirect
Biological Process (BP)regulation of peptidase activity00InformativeDirect
Biological Process (BP)negative regulation of catalytic activity00.0002732InformativeDirect
Biological Process (BP)multi-organism behavior0.00000000055020Highly InformativeDirect
Molecular Function (MF)enzyme regulator activity00.0000000000001974Moderately InformativeDirect
Molecular Function (MF)peptidase regulator activity00InformativeDirect
Molecular Function (MF)enzyme inhibitor activity00.00000000002446InformativeDirect
Molecular Function (MF)serine-type endopeptidase inhibitor activity00.00001094Highly InformativeDirect
Cellular Component (CC)extracellular region part00Moderately InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of metabolic process 0.00000206 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.00000000233 Least Informative Direct
Biological Process (BP) response to stimulus 0.000005479 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.000002208 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.004033 Least Informative Inherited
Biological Process (BP) developmental process 0.002111 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.09798 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.3204 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.6498 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.2937 Least Informative Inherited
Biological Process (BP) localization 0.654 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.6907 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.1133 Least Informative Inherited
Biological Process (BP) regulation of catalytic activity 0 Moderately Informative Direct
Biological Process (BP) reproduction 0.000000000001202 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.00000000000001086 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.0000002457 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0.0000003426 Moderately Informative Direct
Biological Process (BP) system process 0.0000005826 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.000001085 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.00003852 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 0.0001306 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0.00099 Moderately Informative Direct
Biological Process (BP) organ development 0.9892 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.3767 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.07961 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.02391 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.004284 Moderately Informative Inherited
Biological Process (BP) gene expression 0.002615 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.02628 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.4423 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.001817 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.03261 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.01161 Moderately Informative Inherited
Biological Process (BP) tissue development 0.3186 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.04655 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.02322 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.7172 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.2366 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.3209 Moderately Informative Inherited
Biological Process (BP) regulation of peptidase activity 0 Informative Direct
Biological Process (BP) negative regulation of catalytic activity 0.0002732 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0.00000000000003956 Informative Direct
Biological Process (BP) cation homeostasis 0.00000000000007996 Informative Direct
Biological Process (BP) regulation of kinase activity 0.0000000000004072 Informative Direct
Biological Process (BP) regulation of protein phosphorylation 0.00000000005438 Informative Direct
Biological Process (BP) regulation of mitotic cell cycle 0.0000000003049 Informative Direct
Biological Process (BP) posttranscriptional regulation of gene expression 0.00000000127 Informative Direct
Biological Process (BP) response to light stimulus 0.000000003055 Informative Direct
Biological Process (BP) microtubule-based process 0.0000002124 Informative Direct
Biological Process (BP) RNA processing 0.0000005321 Informative Direct
Biological Process (BP) locomotion 0.000001034 Informative Direct
Biological Process (BP) regulation of growth 0.000001518 Informative Direct
Biological Process (BP) cell projection organization 0.000002331 Informative Direct
Biological Process (BP) growth 0.000002985 Informative Direct
Biological Process (BP) alcohol metabolic process 0.000005068 Informative Direct
Biological Process (BP) cellular component movement 0.000009325 Informative Direct
Biological Process (BP) generation of neurons 0.00001025 Informative Direct
Biological Process (BP) phosphorylation 0.00001516 Informative Direct
Biological Process (BP) single organism reproductive process 0.00006659 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.00007501 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.0001959 Informative Direct
Biological Process (BP) muscle structure development 0.0002451 Informative Direct
Biological Process (BP) regulation of cell cycle process 1 Informative Inherited
Biological Process (BP) apoptotic process 0.002995 Informative Inherited
Biological Process (BP) muscle tissue development 0.02894 Informative Inherited
Biological Process (BP) synaptic transmission 0.4149 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.02641 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.03214 Informative Inherited
Biological Process (BP) regulation of cell development 0.04813 Informative Inherited
Biological Process (BP) single-organism behavior 0.5727 Informative Inherited
Biological Process (BP) central nervous system development 0.001594 Informative Inherited
Biological Process (BP) multi-organism behavior 0 Highly Informative Direct
Biological Process (BP) cytoskeleton-dependent intracellular transport 0 Highly Informative Direct
Biological Process (BP) regulation of multicellular organism growth 0 Highly Informative Direct
Biological Process (BP) transition metal ion homeostasis 0 Highly Informative Direct
Biological Process (BP) regulation of translation 0.0000000000002825 Highly Informative Direct
Biological Process (BP) mRNA processing 0.00000000001706 Highly Informative Direct
Biological Process (BP) microtubule-based movement 0.00000000003303 Highly Informative Direct
Biological Process (BP) cell growth 0.00000000003354 Highly Informative Direct
Biological Process (BP) chemotaxis 0.00000000004282 Highly Informative Direct
Biological Process (BP) sterol metabolic process 0.00000000006957 Highly Informative Direct
Biological Process (BP) adult behavior 0.0000000003921 Highly Informative Direct
Biological Process (BP) neuron projection development 0.000000001279 Highly Informative Direct
Biological Process (BP) muscle fiber development 0.000000003333 Highly Informative Direct
Biological Process (BP) developmental growth 0.00000001168 Highly Informative Direct
Biological Process (BP) cell-type specific apoptotic process 0.00000006409 Highly Informative Direct
Biological Process (BP) protein phosphorylation 0.0000009615 Highly Informative Direct
Biological Process (BP) regulation of binding 0.00005017 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0.00005154 Highly Informative Direct
Biological Process (BP) positive regulation of cell cycle process 0.00006389 Highly Informative Direct
Biological Process (BP) neuromuscular process 0.00008647 Highly Informative Direct
Biological Process (BP) cell part morphogenesis 0.0006632 Highly Informative Direct
Biological Process (BP) muscle organ development 0.0009453 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 0.009351 Highly Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 1 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.1164 Highly Informative Inherited
Biological Process (BP) learning or memory 0.2594 Highly Informative Inherited
Molecular Function (MF) binding 0.2959 Least Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.0000000000001974 Moderately Informative Direct
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) peptidase regulator activity 0 Informative Direct
Molecular Function (MF) enzyme inhibitor activity 0.00000000002446 Informative Direct
Molecular Function (MF) tetrapyrrole binding 0.000000006003 Informative Direct
Molecular Function (MF) DNA binding 0.0001146 Informative Direct
Molecular Function (MF) protein dimerization activity 0.0008596 Informative Direct
Molecular Function (MF) serine-type endopeptidase inhibitor activity 0.00001094 Highly Informative Direct
Molecular Function (MF) heme binding 0.000000000003301 Highly Informative Direct
Molecular Function (MF) protein complex binding 0.00000004962 Highly Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) membrane 0.001583 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.9981 Least Informative Inherited
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 0.00004166 Moderately Informative Direct
Cellular Component (CC) cell projection 0.000182 Moderately Informative Direct
Cellular Component (CC) vesicle 0.0006063 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.001811 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.3704 Moderately Informative Inherited
Cellular Component (CC) extracellular matrix 0 Informative Direct
Cellular Component (CC) Golgi apparatus 0.00000002044 Informative Direct
Cellular Component (CC) neuron projection 0.000000225 Informative Direct
Cellular Component (CC) integral to membrane 0.00001738 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.05532 Informative Inherited
Cellular Component (CC) coated vesicle 0.01209 Informative Inherited
Cellular Component (CC) extracellular matrix part 0 Highly Informative Direct
Cellular Component (CC) sarcolemma 0.000004621 Highly Informative Direct
Cellular Component (CC) cilium part 0.000007167 Highly Informative Direct
Cellular Component (CC) proteinaceous extracellular matrix 0.00003938 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.0002133 Highly Informative Direct
Cellular Component (CC) spindle 0.000375 Highly Informative Direct
Cellular Component (CC) transport vesicle 0.000588 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details) Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the abdomen0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0Least InformativeDirect
Phenotypic Abnormality (PA)Abdominal symptom0InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)integument phenotype0.05528Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skin appearance0.0008538InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)pericellular component development variant0Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant0.4184Moderately InformativeInherited
Worm Phenotype (WP)basement membrane remodeling variant0InformativeDirect
Worm Phenotype (WP)somatic gonad development variant0.01106InformativeInherited

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)alimentary system0Least InformativeDirect
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)lung0InformativeDirect
Xenopus ANatomical entity (XAN)adipose tissue0Highly InformativeDirect
Xenopus ANatomical entity (XAN)pancreas0.000486Highly InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0.00007396Moderately InformativeDirect
Biological processHemostasis0.000000000004018InformativeDirect
Biological processCell adhesion0.000000000006398InformativeDirect
Biological processEndocytosis0.00000001136InformativeDirect
Biological processNotch signaling pathway0.0000000000001798Highly InformativeDirect
Biological processBlood coagulation0.000000000003744Highly InformativeDirect
Cellular componentMembrane1Least InformativeInherited
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentExtracellular matrix1InformativeInherited
Cellular componentCoated pit0.000000000002258Highly InformativeDirect
Cellular componentBasement membrane0.0001376Highly InformativeDirect
DomainSignal0Least InformativeDirect
DomainCollagen0.000009145Highly InformativeDirect
Molecular functionHeparin-binding0.000000000131InformativeDirect
Molecular functionCopper0.00000005879InformativeDirect
Molecular functionChromophore0.00000573InformativeDirect
Post-translational modificationProtease inhibitor0InformativeDirect
Post-translational modificationToxin0InformativeDirect
Post-translational modificationMetalloenzyme inhibitor0Highly InformativeDirect
Post-translational modificationIon channel impairing toxin0.0000000003603Highly InformativeDirect
Post-translational modificationNeurotoxin1Highly InformativeInherited
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationGlycoprotein1Least InformativeInherited
Post-translational modificationProteoglycan0.00000002485InformativeDirect
Post-translational modificationPyrrolidone carboxylic acid0.00000008704InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR002223 SSF57362 Protein matches
Abstract

The majority of the sequences having this domain belong to the MEROPS inhibitor family I2, clan IB; the Kunitz/bovine pancreatic trypsin inhibitor family, they inhibit proteases of the S1 family [PubMed14705960] and are restricted to the metazoa with a single exception: Amsacta moorei entomopoxvirus. They are short (~50 residue) alpha/beta proteins with few secondary structures. The fold is constrained by 3 disulphide bonds. The type example for this family is aprotinin (bovine pancreatic trypsin inhibitor) [PubMed1714504] (or basic protease inhibitor), but the family includes numerous other members [PubMed1703675, PubMed1593645, PubMed8159751, PubMed1304909], such as snake venom basic protease; mammalian inter-alpha-trypsin inhibitors; trypstatin, a rat mast cell inhibitor of trypsin; a domain found in an alternatively-spliced form of Alzheimer's amyloid beta-protein; domains at the C-termini of the alpha(1) and alpha(3) chains of type VII and type VI collagens; and tissue factor pathway inhibitor precursor.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 26 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a BPTI-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 26 hidden Markov models representing the BPTI-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]