SUPERFAMILY 1.75 HMM library and genome assignments server


BPTI-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   BPTI-like [ 57361]
Superfamily:   BPTI-like [ 57362] (3)
Families:   Small Kunitz-type inhibitors & BPTI-like toxins [ 57363] (12)
  Soft tick anticoagulant proteins [ 57386] (2)
  Tick tryptase inhibitor-like [ 161132]


Superfamily statistics
Genomes (150) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 5,882 9,169 59
Proteins 2,888 5,015 57


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of metabolic process0.0000000074260.0000009187Least InformativeDirect
Biological Process (BP)response to stimulus0.058280.000002045Least InformativeInherited
Biological Process (BP)regulation of catalytic activity0.00000000000017890Moderately InformativeDirect
Biological Process (BP)reproduction0.000000096280.0000000000006009Moderately InformativeDirect
Biological Process (BP)multi-organism process0.00000048110.000000000000001922Moderately InformativeDirect
Biological Process (BP)regulation of peptidase activity00InformativeDirect
Biological Process (BP)negative regulation of catalytic activity00.0002642InformativeDirect
Biological Process (BP)multi-organism behavior0.00000000064860Highly InformativeDirect
Molecular Function (MF)enzyme regulator activity00.0000000000001183Moderately InformativeDirect
Molecular Function (MF)peptidase regulator activity00InformativeDirect
Molecular Function (MF)enzyme inhibitor activity00.00000000002638InformativeDirect
Molecular Function (MF)serine-type endopeptidase inhibitor activity00.00001145Highly InformativeDirect
Cellular Component (CC)extracellular region part00Moderately InformativeDirect
Cellular Component (CC)host cell part00.000000001628Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of metabolic process 0.0000009187 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.0000000009687 Least Informative Direct
Biological Process (BP) response to stimulus 0.000002045 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.0000009222 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.002199 Least Informative Inherited
Biological Process (BP) developmental process 0.00137 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.07848 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.28 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.5909 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.9949 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.2552 Least Informative Inherited
Biological Process (BP) localization 0.5909 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.6271 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.0965 Least Informative Inherited
Biological Process (BP) regulation of catalytic activity 0 Moderately Informative Direct
Biological Process (BP) reproduction 0.0000000000006009 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.000000000000001922 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0.0000002059 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.0000002157 Moderately Informative Direct
Biological Process (BP) system process 0.0000005284 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.0000006527 Moderately Informative Direct
Biological Process (BP) homeostatic process 0.000005665 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.00002224 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 0.0001014 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0.0007842 Moderately Informative Direct
Biological Process (BP) organ development 0.9879 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.0285 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.3086 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.07707 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.01914 Moderately Informative Inherited
Biological Process (BP) gene expression 0.002075 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.02538 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.4734 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.001743 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.06753 Moderately Informative Inherited
Biological Process (BP) tissue development 0.3126 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.03878 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.02008 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.7161 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of peptidase activity 0 Informative Direct
Biological Process (BP) negative regulation of catalytic activity 0.0002642 Informative Direct
Biological Process (BP) metal ion homeostasis 0 Informative Direct
Biological Process (BP) cellular cation homeostasis 0.000000000000001922 Informative Direct
Biological Process (BP) regulation of kinase activity 0.0000000000002528 Informative Direct
Biological Process (BP) regulation of protein phosphorylation 0.00000000002771 Informative Direct
Biological Process (BP) transmission of nerve impulse 0.00000000005676 Informative Direct
Biological Process (BP) regulation of mitotic cell cycle 0.0000000001805 Informative Direct
Biological Process (BP) posttranscriptional regulation of gene expression 0.0000000008157 Informative Direct
Biological Process (BP) response to light stimulus 0.000000002091 Informative Direct
Biological Process (BP) microtubule-based process 0.0000002102 Informative Direct
Biological Process (BP) RNA processing 0.0000003787 Informative Direct
Biological Process (BP) growth 0.0000004187 Informative Direct
Biological Process (BP) locomotion 0.0000007591 Informative Direct
Biological Process (BP) regulation of growth 0.000001461 Informative Direct
Biological Process (BP) cell projection organization 0.000002357 Informative Direct
Biological Process (BP) alcohol metabolic process 0.000003792 Informative Direct
Biological Process (BP) generation of neurons 0.000007409 Informative Direct
Biological Process (BP) cellular component movement 0.00001029 Informative Direct
Biological Process (BP) phosphorylation 0.00001318 Informative Direct
Biological Process (BP) cell-cell signaling 0.00001459 Informative Direct
Biological Process (BP) single organism reproductive process 0.00006365 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.00007732 Informative Direct
Biological Process (BP) mitotic cell cycle 0.0001416 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.0001455 Informative Direct
Biological Process (BP) muscle structure development 0.0002243 Informative Direct
Biological Process (BP) regulation of cell cycle process 1 Informative Inherited
Biological Process (BP) programmed cell death 0.005761 Informative Inherited
Biological Process (BP) cell cycle process 0.04841 Informative Inherited
Biological Process (BP) muscle tissue development 0.0279 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.02264 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.02682 Informative Inherited
Biological Process (BP) regulation of cell development 0.04016 Informative Inherited
Biological Process (BP) single-organism behavior 0.5594 Informative Inherited
Biological Process (BP) central nervous system development 0.00143 Informative Inherited
Biological Process (BP) multi-organism behavior 0 Highly Informative Direct
Biological Process (BP) cellular transition metal ion homeostasis 0 Highly Informative Direct
Biological Process (BP) regulation of multicellular organism growth 0 Highly Informative Direct
Biological Process (BP) regulation of translation 0.0000000000002006 Highly Informative Direct
Biological Process (BP) axon development 0.000000000006692 Highly Informative Direct
Biological Process (BP) mRNA processing 0.00000000001257 Highly Informative Direct
Biological Process (BP) cell growth 0.00000000003267 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in neuron differentiation 0.00000000003485 Highly Informative Direct
Biological Process (BP) chemotaxis 0.00000000003507 Highly Informative Direct
Biological Process (BP) microtubule-based movement 0.0000000000377 Highly Informative Direct
Biological Process (BP) sterol metabolic process 0.00000000005042 Highly Informative Direct
Biological Process (BP) interphase 0.0000000002393 Highly Informative Direct
Biological Process (BP) developmental maturation 0.000000000358 Highly Informative Direct
Biological Process (BP) adult behavior 0.0000000004248 Highly Informative Direct
Biological Process (BP) muscle fiber development 0.000000002452 Highly Informative Direct
Biological Process (BP) developmental growth 0.000000008874 Highly Informative Direct
Biological Process (BP) cell-type specific apoptotic process 0.00000005175 Highly Informative Direct
Biological Process (BP) protein phosphorylation 0.0000008435 Highly Informative Direct
Biological Process (BP) regulation of binding 0.00003742 Highly Informative Direct
Biological Process (BP) positive regulation of cell cycle process 0.00005214 Highly Informative Direct
Biological Process (BP) neuromuscular process 0.00007656 Highly Informative Direct
Biological Process (BP) cell projection morphogenesis 0.0001718 Highly Informative Direct
Biological Process (BP) muscle organ development 0.000783 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 0.007748 Highly Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 1 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.1092 Highly Informative Inherited
Biological Process (BP) learning or memory 0.2526 Highly Informative Inherited
Molecular Function (MF) binding 0.2169 Least Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.0000000000001183 Moderately Informative Direct
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) peptidase regulator activity 0 Informative Direct
Molecular Function (MF) enzyme inhibitor activity 0.00000000002638 Informative Direct
Molecular Function (MF) tetrapyrrole binding 0.000000004967 Informative Direct
Molecular Function (MF) DNA binding 0.00007138 Informative Direct
Molecular Function (MF) protein dimerization activity 0.0008988 Informative Direct
Molecular Function (MF) serine-type endopeptidase inhibitor activity 0.00001145 Highly Informative Direct
Molecular Function (MF) heme binding 0.000000000001845 Highly Informative Direct
Molecular Function (MF) protein complex binding 0.00000004572 Highly Informative Direct
Cellular Component (CC) membrane 0.0004092 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.9424 Least Informative Inherited
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 0.00003567 Moderately Informative Direct
Cellular Component (CC) cell projection 0.0001086 Moderately Informative Direct
Cellular Component (CC) vesicle 0.0003302 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.0006985 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.3455 Moderately Informative Inherited
Cellular Component (CC) extracellular matrix 0 Informative Direct
Cellular Component (CC) Golgi apparatus 0.0000000169 Informative Direct
Cellular Component (CC) neuron projection 0.000000118 Informative Direct
Cellular Component (CC) integral to membrane 0.00001473 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.0517 Informative Inherited
Cellular Component (CC) coated vesicle 0.01118 Informative Inherited
Cellular Component (CC) host cell part 0.000000001628 Highly Informative Direct
Cellular Component (CC) extracellular matrix part 0.0000000001456 Highly Informative Direct
Cellular Component (CC) cilium part 0.000005754 Highly Informative Direct
Cellular Component (CC) sarcolemma 0.000005917 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.0001621 Highly Informative Direct
Cellular Component (CC) spindle 0.000332 Highly Informative Direct
Cellular Component (CC) transport vesicle 0.0006031 Highly Informative Direct
Cellular Component (CC) neuromuscular junction 0.0006131 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details) Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the abdomen0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0Least InformativeDirect
Phenotypic Abnormality (PA)Abdominal symptom0InformativeDirect
Phenotypic Abnormality (PA)Feeding difficulties in infancy0.0009614Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)integument phenotype0.05481Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skin appearance0.0008177InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)pericellular component development variant0Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant0.4184Moderately InformativeInherited
Worm Phenotype (WP)basement membrane remodeling variant0InformativeDirect
Worm Phenotype (WP)somatic gonad development variant0.01106InformativeInherited

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)alimentary system0Least InformativeDirect
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)lung0InformativeDirect
Xenopus ANatomical entity (XAN)adipose tissue0Highly InformativeDirect
Xenopus ANatomical entity (XAN)pancreas0.0004849Highly InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0.00006625Moderately InformativeDirect
Biological processHemostasis0.000000000003089InformativeDirect
Biological processCell adhesion0.000000000005103InformativeDirect
Biological processEndocytosis0.000000009459InformativeDirect
Biological processNotch signaling pathway0.0000000000001593Highly InformativeDirect
Biological processBlood coagulation0.000000000002875Highly InformativeDirect
Cellular componentMembrane1Least InformativeInherited
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentExtracellular matrix1InformativeInherited
Cellular componentCoated pit0.000000000001998Highly InformativeDirect
Cellular componentBasement membrane0.0001374Highly InformativeDirect
DomainSignal0Least InformativeDirect
DomainCollagen0.000008892Highly InformativeDirect
Molecular functionHeparin-binding0.0000000001164InformativeDirect
Molecular functionCopper0.00000004989InformativeDirect
Molecular functionChromophore0.000005143InformativeDirect
Post-translational modificationProtease inhibitor0InformativeDirect
Post-translational modificationToxin0InformativeDirect
Post-translational modificationMetalloenzyme inhibitor0Highly InformativeDirect
Post-translational modificationIon channel impairing toxin0.000000001062Highly InformativeDirect
Post-translational modificationNeurotoxin1Highly InformativeInherited
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationGlycoprotein1Least InformativeInherited
Post-translational modificationProteoglycan0.00000002546InformativeDirect
Post-translational modificationPyrrolidone carboxylic acid0.00000007352InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR002223 SSF57362 Protein matches
Abstract

The majority of the sequences having this domain belong to the MEROPS inhibitor family I2, clan IB; the Kunitz/bovine pancreatic trypsin inhibitor family, they inhibit proteases of the S1 family [PubMed14705960] and are restricted to the metazoa with a single exception: Amsacta moorei entomopoxvirus. They are short (~50 residue) alpha/beta proteins with few secondary structures. The fold is constrained by 3 disulphide bonds. The type example for this family is aprotinin (bovine pancreatic trypsin inhibitor) [PubMed1714504] (or basic protease inhibitor), but the family includes numerous other members [PubMed1703675, PubMed1593645, PubMed8159751, PubMed1304909], such as snake venom basic protease; mammalian inter-alpha-trypsin inhibitors; trypstatin, a rat mast cell inhibitor of trypsin; a domain found in an alternatively-spliced form of Alzheimer's amyloid beta-protein; domains at the C-termini of the alpha(1) and alpha(3) chains of type VII and type VI collagens; and tissue factor pathway inhibitor precursor.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 26 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a BPTI-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 26 hidden Markov models representing the BPTI-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]