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BPTI-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   BPTI-like [ 57361]
Superfamily:   BPTI-like [ 57362] (3)
Families:   Small Kunitz-type inhibitors & BPTI-like toxins [ 57363] (12)
  Soft tick anticoagulant proteins [ 57386] (2)
  Tick tryptase inhibitor-like [ 161132]


Superfamily statistics
Genomes (155) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 6,091 9,169 59
Proteins 3,022 5,015 57


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of metabolic process0.000000010120.000001756Least InformativeDirect
Biological Process (BP)response to stimulus0.067940.000005138Least InformativeInherited
Biological Process (BP)regulation of catalytic activity0.00000000000020970Moderately InformativeDirect
Biological Process (BP)reproduction0.00000011760.000000000001148Moderately InformativeDirect
Biological Process (BP)multi-organism process0.00000079060.000000000000007318Moderately InformativeDirect
Biological Process (BP)regulation of peptidase activity00InformativeDirect
Biological Process (BP)negative regulation of catalytic activity00.0002444InformativeDirect
Biological Process (BP)multi-organism behavior0.00000000038350Highly InformativeDirect
Molecular Function (MF)enzyme regulator activity00.0000000000001928Moderately InformativeDirect
Molecular Function (MF)peptidase regulator activity00InformativeDirect
Molecular Function (MF)enzyme inhibitor activity00.00000000002514InformativeDirect
Molecular Function (MF)serine-type endopeptidase inhibitor activity00.00001093Highly InformativeDirect
Cellular Component (CC)extracellular region part00Moderately InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of metabolic process 0.000001756 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.000000002266 Least Informative Direct
Biological Process (BP) response to stimulus 0.000005138 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.000001952 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.003881 Least Informative Inherited
Biological Process (BP) developmental process 0.002099 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.09713 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.3186 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.6469 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.2922 Least Informative Inherited
Biological Process (BP) localization 0.6444 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.6931 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.1112 Least Informative Inherited
Biological Process (BP) regulation of catalytic activity 0 Moderately Informative Direct
Biological Process (BP) reproduction 0.000000000001148 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.000000000000007318 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.00000024 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0.0000003253 Moderately Informative Direct
Biological Process (BP) system process 0.0000005442 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.0000009801 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.00003596 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 0.0001408 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0.0009828 Moderately Informative Direct
Biological Process (BP) organ development 0.9888 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.01501 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.3593 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.07666 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.02405 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.004078 Moderately Informative Inherited
Biological Process (BP) gene expression 0.002577 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.02591 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.4508 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.001765 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.03221 Moderately Informative Inherited
Biological Process (BP) tissue development 0.3167 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.04696 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.02293 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.7125 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.2424 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.3295 Moderately Informative Inherited
Biological Process (BP) regulation of peptidase activity 0 Informative Direct
Biological Process (BP) negative regulation of catalytic activity 0.0002444 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0.00000000000003117 Informative Direct
Biological Process (BP) cation homeostasis 0.00000000000006699 Informative Direct
Biological Process (BP) regulation of kinase activity 0.0000000000003677 Informative Direct
Biological Process (BP) regulation of protein phosphorylation 0.00000000004584 Informative Direct
Biological Process (BP) regulation of mitotic cell cycle 0.0000000002988 Informative Direct
Biological Process (BP) posttranscriptional regulation of gene expression 0.000000001251 Informative Direct
Biological Process (BP) response to light stimulus 0.000000002938 Informative Direct
Biological Process (BP) microtubule-based process 0.00000022 Informative Direct
Biological Process (BP) RNA processing 0.0000005163 Informative Direct
Biological Process (BP) locomotion 0.000001051 Informative Direct
Biological Process (BP) regulation of growth 0.000001486 Informative Direct
Biological Process (BP) cell projection organization 0.000002324 Informative Direct
Biological Process (BP) growth 0.000002881 Informative Direct
Biological Process (BP) alcohol metabolic process 0.000005013 Informative Direct
Biological Process (BP) cellular component movement 0.000009732 Informative Direct
Biological Process (BP) generation of neurons 0.00001003 Informative Direct
Biological Process (BP) phosphorylation 0.00001527 Informative Direct
Biological Process (BP) single organism reproductive process 0.00006375 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.00007684 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.0001925 Informative Direct
Biological Process (BP) muscle structure development 0.0002382 Informative Direct
Biological Process (BP) regulation of cell cycle process 1 Informative Inherited
Biological Process (BP) apoptotic process 0.002989 Informative Inherited
Biological Process (BP) muscle tissue development 0.02827 Informative Inherited
Biological Process (BP) synaptic transmission 0.4104 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.02547 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.03027 Informative Inherited
Biological Process (BP) regulation of cell development 0.04466 Informative Inherited
Biological Process (BP) single-organism behavior 0.5882 Informative Inherited
Biological Process (BP) central nervous system development 0.00154 Informative Inherited
Biological Process (BP) multi-organism behavior 0 Highly Informative Direct
Biological Process (BP) regulation of multicellular organism growth 0 Highly Informative Direct
Biological Process (BP) transition metal ion homeostasis 0 Highly Informative Direct
Biological Process (BP) regulation of translation 0.0000000000002967 Highly Informative Direct
Biological Process (BP) mRNA processing 0.00000000001523 Highly Informative Direct
Biological Process (BP) cell growth 0.00000000003157 Highly Informative Direct
Biological Process (BP) microtubule-based movement 0.00000000003303 Highly Informative Direct
Biological Process (BP) chemotaxis 0.00000000004521 Highly Informative Direct
Biological Process (BP) sterol metabolic process 0.00000000007043 Highly Informative Direct
Biological Process (BP) adult behavior 0.0000000003884 Highly Informative Direct
Biological Process (BP) developmental maturation 0.0000000006363 Highly Informative Direct
Biological Process (BP) neuron projection development 0.000000001315 Highly Informative Direct
Biological Process (BP) muscle fiber development 0.000000003165 Highly Informative Direct
Biological Process (BP) developmental growth 0.00000001384 Highly Informative Direct
Biological Process (BP) cell-type specific apoptotic process 0.0000000599 Highly Informative Direct
Biological Process (BP) protein phosphorylation 0.0000009661 Highly Informative Direct
Biological Process (BP) regulation of binding 0.00004409 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0.00005637 Highly Informative Direct
Biological Process (BP) positive regulation of cell cycle process 0.00006342 Highly Informative Direct
Biological Process (BP) neuromuscular process 0.00009175 Highly Informative Direct
Biological Process (BP) cell part morphogenesis 0.0006664 Highly Informative Direct
Biological Process (BP) muscle organ development 0.0009073 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 0.008657 Highly Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 1 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.1242 Highly Informative Inherited
Biological Process (BP) learning or memory 0.2399 Highly Informative Inherited
Molecular Function (MF) binding 0.2872 Least Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.0000000000001928 Moderately Informative Direct
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) peptidase regulator activity 0 Informative Direct
Molecular Function (MF) enzyme inhibitor activity 0.00000000002514 Informative Direct
Molecular Function (MF) tetrapyrrole binding 0.000000005949 Informative Direct
Molecular Function (MF) DNA binding 0.0001087 Informative Direct
Molecular Function (MF) protein dimerization activity 0.0008726 Informative Direct
Molecular Function (MF) serine-type endopeptidase inhibitor activity 0.00001093 Highly Informative Direct
Molecular Function (MF) heme binding 0.000000000003189 Highly Informative Direct
Molecular Function (MF) protein complex binding 0.00000004904 Highly Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) membrane 0.001468 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.9945 Least Informative Inherited
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 0.00004226 Moderately Informative Direct
Cellular Component (CC) cell projection 0.0001616 Moderately Informative Direct
Cellular Component (CC) vesicle 0.0006035 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.001683 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.3692 Moderately Informative Inherited
Cellular Component (CC) extracellular matrix 0 Informative Direct
Cellular Component (CC) Golgi apparatus 0.00000002007 Informative Direct
Cellular Component (CC) neuron projection 0.0000001849 Informative Direct
Cellular Component (CC) integral to membrane 0.00001749 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.05563 Informative Inherited
Cellular Component (CC) coated vesicle 0.01171 Informative Inherited
Cellular Component (CC) extracellular matrix part 0.0000000002258 Highly Informative Direct
Cellular Component (CC) sarcolemma 0.000004832 Highly Informative Direct
Cellular Component (CC) cilium part 0.00000662 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.0002034 Highly Informative Direct
Cellular Component (CC) spindle 0.0003756 Highly Informative Direct
Cellular Component (CC) transport vesicle 0.000586 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details) Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the abdomen0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0Least InformativeDirect
Phenotypic Abnormality (PA)Abdominal symptom0InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)integument phenotype0.05416Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skin appearance0.0008102InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)pericellular component development variant0Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant0.4184Moderately InformativeInherited
Worm Phenotype (WP)basement membrane remodeling variant0InformativeDirect
Worm Phenotype (WP)somatic gonad development variant0.01106InformativeInherited

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)alimentary system0Least InformativeDirect
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)lung0InformativeDirect
Xenopus ANatomical entity (XAN)adipose tissue0Highly InformativeDirect
Xenopus ANatomical entity (XAN)pancreas0.0004859Highly InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0.00007397Moderately InformativeDirect
Biological processHemostasis0.000000000003514InformativeDirect
Biological processCell adhesion0.000000000006325InformativeDirect
Biological processEndocytosis0.00000001071InformativeDirect
Biological processNotch signaling pathway0.0000000000001812Highly InformativeDirect
Biological processBlood coagulation0.000000000003269Highly InformativeDirect
Cellular componentMembrane1Least InformativeInherited
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentExtracellular matrix1InformativeInherited
Cellular componentCoated pit0.000000000002271Highly InformativeDirect
Cellular componentBasement membrane0.0001374Highly InformativeDirect
DomainSignal0Least InformativeDirect
DomainCollagen0.000009259Highly InformativeDirect
Molecular functionHeparin-binding0.0000000001322InformativeDirect
Molecular functionCopper0.00000005874InformativeDirect
Molecular functionChromophore0.000005775InformativeDirect
Post-translational modificationProtease inhibitor0InformativeDirect
Post-translational modificationToxin0InformativeDirect
Post-translational modificationMetalloenzyme inhibitor0Highly InformativeDirect
Post-translational modificationIon channel impairing toxin0.0000000003613Highly InformativeDirect
Post-translational modificationNeurotoxin1Highly InformativeInherited
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationGlycoprotein1Least InformativeInherited
Post-translational modificationProteoglycan0.00000002554InformativeDirect
Post-translational modificationPyrrolidone carboxylic acid0.00000008927InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR002223 SSF57362 Protein matches
Abstract

The majority of the sequences having this domain belong to the MEROPS inhibitor family I2, clan IB; the Kunitz/bovine pancreatic trypsin inhibitor family, they inhibit proteases of the S1 family [PubMed14705960] and are restricted to the metazoa with a single exception: Amsacta moorei entomopoxvirus. They are short (~50 residue) alpha/beta proteins with few secondary structures. The fold is constrained by 3 disulphide bonds. The type example for this family is aprotinin (bovine pancreatic trypsin inhibitor) [PubMed1714504] (or basic protease inhibitor), but the family includes numerous other members [PubMed1703675, PubMed1593645, PubMed8159751, PubMed1304909], such as snake venom basic protease; mammalian inter-alpha-trypsin inhibitors; trypstatin, a rat mast cell inhibitor of trypsin; a domain found in an alternatively-spliced form of Alzheimer's amyloid beta-protein; domains at the C-termini of the alpha(1) and alpha(3) chains of type VII and type VI collagens; and tissue factor pathway inhibitor precursor.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 26 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a BPTI-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 26 hidden Markov models representing the BPTI-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]