SUPERFAMILY 1.75 HMM library and genome assignments server


BPTI-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   BPTI-like [ 57361]
Superfamily:   BPTI-like [ 57362] (3)
Families:   Small Kunitz-type inhibitors & BPTI-like toxins [ 57363] (12)
  Soft tick anticoagulant proteins [ 57386] (2)
  Tick tryptase inhibitor-like [ 161132]


Superfamily statistics
Genomes (155) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 6,091 9,169 59
Proteins 3,022 5,015 57


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of metabolic process9.704e-091.979e-06Least InformativeDirect
Biological Process (BP)response to stimulus0.067426.173e-06Least InformativeInherited
Biological Process (BP)regulation of catalytic activity1.986e-130Moderately InformativeDirect
Biological Process (BP)reproduction1.168e-071.41e-12Moderately InformativeDirect
Biological Process (BP)multi-organism process7.743e-077.341e-15Moderately InformativeDirect
Biological Process (BP)regulation of peptidase activity00InformativeDirect
Biological Process (BP)negative regulation of catalytic activity00.0002687InformativeDirect
Biological Process (BP)multi-organism behavior4.312e-100Highly InformativeDirect
Molecular Function (MF)enzyme regulator activity02.132e-13Moderately InformativeDirect
Molecular Function (MF)peptidase regulator activity00InformativeDirect
Molecular Function (MF)enzyme inhibitor activity02.627e-11InformativeDirect
Molecular Function (MF)serine-type endopeptidase inhibitor activity01.092e-05Highly InformativeDirect
Cellular Component (CC)extracellular region part00Moderately InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of metabolic process 1.979e-06 Least Informative Direct
Biological Process (BP) multicellular organismal process 3.113e-09 Least Informative Direct
Biological Process (BP) response to stimulus 6.173e-06 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 2.337e-06 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.004537 Least Informative Inherited
Biological Process (BP) developmental process 0.002402 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.1025 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.3019 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.3295 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.6601 Least Informative Inherited
Biological Process (BP) localization 0.645 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.7008 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.1159 Least Informative Inherited
Biological Process (BP) regulation of catalytic activity 0 Moderately Informative Direct
Biological Process (BP) reproduction 1.41e-12 Moderately Informative Direct
Biological Process (BP) multi-organism process 7.341e-15 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 2.126e-07 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 3.249e-07 Moderately Informative Direct
Biological Process (BP) system process 5.432e-07 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 1.01e-06 Moderately Informative Direct
Biological Process (BP) homeostatic process 5.721e-06 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 3.806e-05 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 0.0001359 Moderately Informative Direct
Biological Process (BP) organ development 0.9885 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.01519 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.3646 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.07718 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.02586 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.00105 Moderately Informative Inherited
Biological Process (BP) gene expression 0.002745 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.02576 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.4507 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.001713 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.0324 Moderately Informative Inherited
Biological Process (BP) tissue development 0.3179 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.048 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.02396 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.7183 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.2468 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.3356 Moderately Informative Inherited
Biological Process (BP) regulation of peptidase activity 0 Informative Direct
Biological Process (BP) negative regulation of catalytic activity 0.0002687 Informative Direct
Biological Process (BP) cellular chemical homeostasis 3.456e-14 Informative Direct
Biological Process (BP) cation homeostasis 4.772e-14 Informative Direct
Biological Process (BP) regulation of kinase activity 3.886e-13 Informative Direct
Biological Process (BP) regulation of protein phosphorylation 4.428e-11 Informative Direct
Biological Process (BP) regulation of mitotic cell cycle 3.277e-10 Informative Direct
Biological Process (BP) posttranscriptional regulation of gene expression 1.369e-09 Informative Direct
Biological Process (BP) response to light stimulus 3.155e-09 Informative Direct
Biological Process (BP) microtubule-based process 2.376e-07 Informative Direct
Biological Process (BP) RNA processing 5.591e-07 Informative Direct
Biological Process (BP) locomotion 1.157e-06 Informative Direct
Biological Process (BP) regulation of growth 1.513e-06 Informative Direct
Biological Process (BP) cell projection organization 2.415e-06 Informative Direct
Biological Process (BP) growth 2.853e-06 Informative Direct
Biological Process (BP) alcohol metabolic process 5.166e-06 Informative Direct
Biological Process (BP) cellular component movement 9.883e-06 Informative Direct
Biological Process (BP) generation of neurons 1.136e-05 Informative Direct
Biological Process (BP) phosphorylation 1.671e-05 Informative Direct
Biological Process (BP) single organism reproductive process 6.457e-05 Informative Direct
Biological Process (BP) cellular component morphogenesis 7.924e-05 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.0002007 Informative Direct
Biological Process (BP) muscle structure development 0.0002384 Informative Direct
Biological Process (BP) regulation of cell cycle process 1 Informative Inherited
Biological Process (BP) apoptotic process 0.003028 Informative Inherited
Biological Process (BP) muscle tissue development 0.02822 Informative Inherited
Biological Process (BP) synaptic transmission 0.4084 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.02686 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.03136 Informative Inherited
Biological Process (BP) regulation of cell development 0.04676 Informative Inherited
Biological Process (BP) single-organism behavior 0.5736 Informative Inherited
Biological Process (BP) central nervous system development 0.001456 Informative Inherited
Biological Process (BP) multi-organism behavior 0 Highly Informative Direct
Biological Process (BP) regulation of multicellular organism growth 0 Highly Informative Direct
Biological Process (BP) transition metal ion homeostasis 0 Highly Informative Direct
Biological Process (BP) regulation of translation 3.266e-13 Highly Informative Direct
Biological Process (BP) axon development 1.042e-11 Highly Informative Direct
Biological Process (BP) mRNA processing 1.654e-11 Highly Informative Direct
Biological Process (BP) cell growth 3.133e-11 Highly Informative Direct
Biological Process (BP) microtubule-based movement 3.466e-11 Highly Informative Direct
Biological Process (BP) chemotaxis 5.211e-11 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in neuron differentiation 5.731e-11 Highly Informative Direct
Biological Process (BP) sterol metabolic process 7.524e-11 Highly Informative Direct
Biological Process (BP) adult behavior 3.907e-10 Highly Informative Direct
Biological Process (BP) developmental maturation 6.731e-10 Highly Informative Direct
Biological Process (BP) muscle fiber development 3.359e-09 Highly Informative Direct
Biological Process (BP) developmental growth 1.361e-08 Highly Informative Direct
Biological Process (BP) cell-type specific apoptotic process 6.276e-08 Highly Informative Direct
Biological Process (BP) protein phosphorylation 1.068e-06 Highly Informative Direct
Biological Process (BP) regulation of binding 4.703e-05 Highly Informative Direct
Biological Process (BP) positive regulation of cell cycle process 6.573e-05 Highly Informative Direct
Biological Process (BP) neuromuscular process 9.258e-05 Highly Informative Direct
Biological Process (BP) cell projection morphogenesis 0.000175 Highly Informative Direct
Biological Process (BP) muscle organ development 0.0008123 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 0.00905 Highly Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 1 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.1062 Highly Informative Inherited
Biological Process (BP) learning or memory 0.2662 Highly Informative Inherited
Molecular Function (MF) binding 0.3027 Least Informative Inherited
Molecular Function (MF) enzyme regulator activity 2.132e-13 Moderately Informative Direct
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) peptidase regulator activity 0 Informative Direct
Molecular Function (MF) enzyme inhibitor activity 2.627e-11 Informative Direct
Molecular Function (MF) tetrapyrrole binding 5.596e-09 Informative Direct
Molecular Function (MF) DNA binding 0.0001174 Informative Direct
Molecular Function (MF) protein dimerization activity 0.0008736 Informative Direct
Molecular Function (MF) serine-type endopeptidase inhibitor activity 1.092e-05 Highly Informative Direct
Molecular Function (MF) heme binding 3.165e-12 Highly Informative Direct
Molecular Function (MF) protein complex binding 4.907e-08 Highly Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) membrane 0.001752 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 4.618e-05 Moderately Informative Direct
Cellular Component (CC) cell projection 0.0001632 Moderately Informative Direct
Cellular Component (CC) vesicle 0.0006329 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.001855 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.3754 Moderately Informative Inherited
Cellular Component (CC) extracellular matrix 0 Informative Direct
Cellular Component (CC) Golgi apparatus 2.285e-08 Informative Direct
Cellular Component (CC) neuron projection 1.852e-07 Informative Direct
Cellular Component (CC) integral to membrane 1.913e-05 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.05757 Informative Inherited
Cellular Component (CC) coated vesicle 0.01124 Informative Inherited
Cellular Component (CC) extracellular matrix part 2.472e-10 Highly Informative Direct
Cellular Component (CC) sarcolemma 4.756e-06 Highly Informative Direct
Cellular Component (CC) cilium part 6.894e-06 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.000198 Highly Informative Direct
Cellular Component (CC) spindle 0.0003897 Highly Informative Direct
Cellular Component (CC) transport vesicle 0.0006002 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details) Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the abdomen0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0Least InformativeDirect
Phenotypic Abnormality (PA)Abdominal symptom0InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)integument phenotype0.05416Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skin appearance0.0008102InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)pericellular component development variant0Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant0.4184Moderately InformativeInherited
Worm Phenotype (WP)basement membrane remodeling variant0InformativeDirect
Worm Phenotype (WP)somatic gonad development variant0.01106InformativeInherited

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)alimentary system0Least InformativeDirect
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)lung0InformativeDirect
Xenopus ANatomical entity (XAN)adipose tissue0Highly InformativeDirect
Xenopus ANatomical entity (XAN)pancreas0.0004859Highly InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis7.397e-05Moderately InformativeDirect
Biological processHemostasis3.514e-12InformativeDirect
Biological processCell adhesion6.325e-12InformativeDirect
Biological processEndocytosis1.071e-08InformativeDirect
Biological processNotch signaling pathway1.812e-13Highly InformativeDirect
Biological processBlood coagulation3.269e-12Highly InformativeDirect
Cellular componentMembrane1Least InformativeInherited
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentExtracellular matrix1InformativeInherited
Cellular componentCoated pit2.271e-12Highly InformativeDirect
Cellular componentBasement membrane0.0001374Highly InformativeDirect
DomainSignal0Least InformativeDirect
DomainCollagen9.259e-06Highly InformativeDirect
Molecular functionHeparin-binding1.322e-10InformativeDirect
Molecular functionCopper5.874e-08InformativeDirect
Molecular functionChromophore5.775e-06InformativeDirect
Post-translational modificationProtease inhibitor0InformativeDirect
Post-translational modificationToxin0InformativeDirect
Post-translational modificationMetalloenzyme inhibitor0Highly InformativeDirect
Post-translational modificationIon channel impairing toxin3.613e-10Highly InformativeDirect
Post-translational modificationNeurotoxin1Highly InformativeInherited
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationGlycoprotein1Least InformativeInherited
Post-translational modificationProteoglycan2.554e-08InformativeDirect
Post-translational modificationPyrrolidone carboxylic acid8.927e-08InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR002223 SSF57362 Protein matches
Abstract

The majority of the sequences having this domain belong to the MEROPS inhibitor family I2, clan IB; the Kunitz/bovine pancreatic trypsin inhibitor family, they inhibit proteases of the S1 family [PubMed14705960] and are restricted to the metazoa with a single exception: Amsacta moorei entomopoxvirus. They are short (~50 residue) alpha/beta proteins with few secondary structures. The fold is constrained by 3 disulphide bonds. The type example for this family is aprotinin (bovine pancreatic trypsin inhibitor) [PubMed1714504] (or basic protease inhibitor), but the family includes numerous other members [PubMed1703675, PubMed1593645, PubMed8159751, PubMed1304909], such as snake venom basic protease; mammalian inter-alpha-trypsin inhibitors; trypstatin, a rat mast cell inhibitor of trypsin; a domain found in an alternatively-spliced form of Alzheimer's amyloid beta-protein; domains at the C-termini of the alpha(1) and alpha(3) chains of type VII and type VI collagens; and tissue factor pathway inhibitor precursor.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 26 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a BPTI-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 26 hidden Markov models representing the BPTI-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]