SUPERFAMILY 1.75 HMM library and genome assignments server


Snake toxin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Snake toxin-like [ 57301]
Superfamily:   Snake toxin-like [ 57302] (3)
Families:   Snake venom toxins [ 57303] (27)
  Dendroaspin [ 57351]
  Extracellular domain of cell surface receptors [ 57354] (6)


Superfamily statistics
Genomes (140) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 3,973 5,624 76
Proteins 3,634 5,116 68


Functional annotation
General category Processes_EC
Detailed category Toxins/defense

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process1.508e-080.0003234Least InformativeDirect
Biological Process (BP)regulation of metabolic process10.05405Least InformativeInherited
Biological Process (BP)localization0.47270.0103Least InformativeInherited
Biological Process (BP)developmental process0.038770Least InformativeInherited
Biological Process (BP)multicellular organismal process0.016870Least InformativeInherited
Biological Process (BP)multi-organism process3.307e-060.0003756Moderately InformativeDirect
Biological Process (BP)negative regulation of metabolic process0.010571Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.00017530.07206Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.0018670.2902Moderately InformativeInherited
Biological Process (BP)organ development0.15477.726e-07Moderately InformativeInherited
Biological Process (BP)tissue development0.0067331.956e-10Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.22770.0005521Moderately InformativeInherited
Biological Process (BP)organic substance transport0.12440.4947Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.35460.1763Moderately InformativeInherited
Biological Process (BP)cardiovascular system development0.00021892.971e-14InformativeDirect
Biological Process (BP)tissue morphogenesis0.00049163.945e-09InformativeDirect
Biological Process (BP)gland development0.00050720.0004687InformativeDirect
Biological Process (BP)growth0.013741.223e-06InformativeInherited
Biological Process (BP)regulation of immune effector process8.523e-090.2996InformativeInherited
Biological Process (BP)muscle tissue development0.0048620.9392InformativeInherited
Biological Process (BP)regulation of hormone levels0.0064070.07669InformativeInherited
Biological Process (BP)negative regulation of response to stimulus0.029490.1328InformativeInherited
Biological Process (BP)regulation of immune response0.23950.8332InformativeInherited
Biological Process (BP)regulation of defense response1.226e-060.1686InformativeInherited
Biological Process (BP)regulation of response to external stimulus0.033010.3825InformativeInherited
Biological Process (BP)negative regulation of protein metabolic process0.001240.8364InformativeInherited
Biological Process (BP)embryo development ending in birth or egg hatching6.207e-060.006023InformativeInherited
Biological Process (BP)regulation of acute inflammatory response2.238e-131.231e-08Highly InformativeDirect
Biological Process (BP)regulation of humoral immune response3.263e-132.715e-05Highly InformativeDirect
Biological Process (BP)regulation of protein processing1.241e-126.408e-05Highly InformativeDirect
Biological Process (BP)pathogenesis2.151e-094.315e-05Highly InformativeDirect
Biological Process (BP)endocrine system development1.443e-060.0001211Highly InformativeDirect
Biological Process (BP)hormone transport1.818e-065.611e-06Highly InformativeDirect
Biological Process (BP)negative regulation of immune system process9.489e-060.0003502Highly InformativeDirect
Biological Process (BP)organic hydroxy compound transport3.73e-052.095e-05Highly InformativeDirect
Cellular Component (CC)membrane0.018790Least InformativeInherited
Cellular Component (CC)plasma membrane5.727e-050Moderately InformativeDirect
Cellular Component (CC)cell surface2.166e-120InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 0.0003234 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 1.118e-13 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) protein metabolic process 3.162e-09 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 1.035e-05 Least Informative Direct
Biological Process (BP) localization 0.0103 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.2341 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.05405 Least Informative Inherited
Biological Process (BP) multi-organism process 0.0003756 Moderately Informative Direct
Biological Process (BP) tissue development 1.956e-10 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0 Moderately Informative Direct
Biological Process (BP) reproduction 9.888e-12 Moderately Informative Direct
Biological Process (BP) organ development 7.726e-07 Moderately Informative Direct
Biological Process (BP) cell differentiation 0 Moderately Informative Direct
Biological Process (BP) response to organic substance 4.043e-12 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.0005521 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 1.091e-14 Moderately Informative Direct
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 3.77e-15 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 3.927e-09 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 4.506e-06 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.4296 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.1763 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.1952 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.05308 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.1405 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.7466 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.4947 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.01781 Moderately Informative Inherited
Biological Process (BP) system process 0.9741 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.01693 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.002374 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.8185 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 0.6063 Moderately Informative Inherited
Biological Process (BP) immune system process 0.01623 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.2902 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.2695 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.07206 Moderately Informative Inherited
Biological Process (BP) cardiovascular system development 2.971e-14 Informative Direct
Biological Process (BP) tissue morphogenesis 3.945e-09 Informative Direct
Biological Process (BP) gland development 0.0004687 Informative Direct
Biological Process (BP) growth 1.223e-06 Informative Direct
Biological Process (BP) organ morphogenesis 5.113e-09 Informative Direct
Biological Process (BP) developmental process involved in reproduction 0.0001309 Informative Direct
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0 Informative Direct
Biological Process (BP) positive regulation of developmental process 1.258e-13 Informative Direct
Biological Process (BP) regulation of growth 5.333e-13 Informative Direct
Biological Process (BP) tube development 1.684e-10 Informative Direct
Biological Process (BP) positive regulation of protein modification process 2.31e-10 Informative Direct
Biological Process (BP) locomotion 2.916e-10 Informative Direct
Biological Process (BP) regulation of protein phosphorylation 1.067e-08 Informative Direct
Biological Process (BP) cellular process involved in reproduction 1.351e-08 Informative Direct
Biological Process (BP) single organism reproductive process 1.476e-08 Informative Direct
Biological Process (BP) embryonic morphogenesis 3.465e-08 Informative Direct
Biological Process (BP) sensory organ development 3.095e-07 Informative Direct
Biological Process (BP) localization of cell 3.787e-07 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 4.575e-07 Informative Direct
Biological Process (BP) cellular component movement 5.096e-06 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 6.407e-06 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 6.967e-06 Informative Direct
Biological Process (BP) lipid localization 1.34e-05 Informative Direct
Biological Process (BP) response to wounding 2.122e-05 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 3.143e-05 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 3.494e-05 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 8.587e-05 Informative Direct
Biological Process (BP) negative regulation of developmental process 0.0001959 Informative Direct
Biological Process (BP) generation of neurons 0.0003554 Informative Direct
Biological Process (BP) apoptotic process 0.0007735 Informative Direct
Biological Process (BP) negative regulation of signaling 0.3072 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.4174 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.004849 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) regulation of secretion 0.02536 Informative Inherited
Biological Process (BP) negative regulation of transport 0.05812 Informative Inherited
Biological Process (BP) defense response 0.08484 Informative Inherited
Biological Process (BP) response to other organism 1 Informative Inherited
Biological Process (BP) synaptic transmission 0.006089 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.0485 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.6252 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.324 Informative Inherited
Biological Process (BP) leukocyte activation 0.1579 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.002557 Informative Inherited
Biological Process (BP) sexual reproduction 0.002937 Informative Inherited
Biological Process (BP) regulation of kinase activity 1 Informative Inherited
Biological Process (BP) response to organonitrogen compound 1 Informative Inherited
Biological Process (BP) response to hormone stimulus 1 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.2996 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.01352 Informative Inherited
Biological Process (BP) regulation of locomotion 0.0359 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) cell projection organization 0.304 Informative Inherited
Biological Process (BP) muscle tissue development 0.9392 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.119 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.07669 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.7957 Informative Inherited
Biological Process (BP) regulation of cell development 0.8032 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 0.1765 Informative Inherited
Biological Process (BP) protein complex assembly 0.1918 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.1328 Informative Inherited
Biological Process (BP) regulation of immune response 0.8332 Informative Inherited
Biological Process (BP) regulation of defense response 0.1686 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.3825 Informative Inherited
Biological Process (BP) positive regulation of cell proliferation 0.1786 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.8364 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.006023 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.03999 Informative Inherited
Biological Process (BP) regulation of acute inflammatory response 1.231e-08 Highly Informative Direct
Biological Process (BP) regulation of humoral immune response 2.715e-05 Highly Informative Direct
Biological Process (BP) regulation of protein processing 6.408e-05 Highly Informative Direct
Biological Process (BP) pathogenesis 4.315e-05 Highly Informative Direct
Biological Process (BP) endocrine system development 0.0001211 Highly Informative Direct
Biological Process (BP) hormone transport 5.611e-06 Highly Informative Direct
Biological Process (BP) negative regulation of immune system process 0.0003502 Highly Informative Direct
Biological Process (BP) organic hydroxy compound transport 2.095e-05 Highly Informative Direct
Biological Process (BP) protein phosphorylation 0 Highly Informative Direct
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0 Highly Informative Direct
Biological Process (BP) regulation of striated muscle tissue development 0 Highly Informative Direct
Biological Process (BP) pattern specification process 0 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 0 Highly Informative Direct
Biological Process (BP) positive regulation of growth 0 Highly Informative Direct
Biological Process (BP) stem cell development 7.906e-13 Highly Informative Direct
Biological Process (BP) respiratory system development 1.261e-10 Highly Informative Direct
Biological Process (BP) skeletal system development 2.095e-08 Highly Informative Direct
Biological Process (BP) mesenchyme development 5.246e-08 Highly Informative Direct
Biological Process (BP) respiratory tube development 2.728e-07 Highly Informative Direct
Biological Process (BP) cell division 3.758e-06 Highly Informative Direct
Biological Process (BP) cellular process involved in reproduction in multicellular organism 5.765e-06 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 1.706e-05 Highly Informative Direct
Biological Process (BP) connective tissue development 1.954e-05 Highly Informative Direct
Biological Process (BP) regulation of multicellular organism growth 2.054e-05 Highly Informative Direct
Biological Process (BP) regulation of T cell activation 2.186e-05 Highly Informative Direct
Biological Process (BP) angiogenesis 3.106e-05 Highly Informative Direct
Biological Process (BP) myeloid leukocyte activation 4.67e-05 Highly Informative Direct
Biological Process (BP) regulation of peptide transport 5.384e-05 Highly Informative Direct
Biological Process (BP) negative regulation of secretion 6.29e-05 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 8.85e-05 Highly Informative Direct
Biological Process (BP) retina development in camera-type eye 0.0001058 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0.0004866 Highly Informative Direct
Biological Process (BP) cell-type specific apoptotic process 0.002581 Highly Informative Inherited
Biological Process (BP) cell growth 0.009995 Highly Informative Inherited
Biological Process (BP) developmental growth 0.0139 Highly Informative Inherited
Biological Process (BP) renal system development 0.0121 Highly Informative Inherited
Biological Process (BP) defense response to bacterium 0.03492 Highly Informative Inherited
Biological Process (BP) cell projection morphogenesis 0.6483 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.02267 Highly Informative Inherited
Biological Process (BP) cell fate commitment 0.01831 Highly Informative Inherited
Biological Process (BP) regulation of hormone secretion 0.009619 Highly Informative Inherited
Biological Process (BP) regulation of innate immune response 0.1608 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.001677 Highly Informative Inherited
Biological Process (BP) positive regulation of cell activation 0.01539 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.1081 Highly Informative Inherited
Biological Process (BP) response to peptide hormone stimulus 0.008561 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 0.7895 Highly Informative Inherited
Biological Process (BP) regulation of cell adhesion 0.002652 Highly Informative Inherited
Biological Process (BP) response to carbohydrate stimulus 0.01224 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.003307 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in neuron differentiation 0.03399 Highly Informative Inherited
Biological Process (BP) chemotaxis 0.5272 Highly Informative Inherited
Biological Process (BP) axon development 0.7168 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 0.3617 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.4133 Highly Informative Inherited
Biological Process (BP) regulation of organ morphogenesis 0.01313 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.2004 Highly Informative Inherited
Biological Process (BP) branching morphogenesis of an epithelial tube 0.06254 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.001363 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.05117 Moderately Informative Inherited
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.0001192 Informative Direct
Molecular Function (MF) purine ribonucleoside binding 0.0001828 Informative Direct
Molecular Function (MF) nucleotide binding 0.002544 Informative Inherited
Molecular Function (MF) protein kinase activity 0 Highly Informative Direct
Molecular Function (MF) protein complex binding 0 Highly Informative Direct
Molecular Function (MF) ATP binding 4.72e-06 Highly Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) protein complex 0.1964 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 0.0004846 Moderately Informative Direct
Cellular Component (CC) cell projection 0.2044 Moderately Informative Inherited
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) intrinsic to plasma membrane 4.944e-09 Informative Direct
Cellular Component (CC) endosome 2.941e-06 Informative Direct
Cellular Component (CC) integral to membrane 0.7549 Informative Inherited
Cellular Component (CC) integral to plasma membrane 2.734e-06 Highly Informative Direct
Cellular Component (CC) receptor complex 0 Highly Informative Direct
Cellular Component (CC) membrane raft 0.06407 Highly Informative Inherited
Cellular Component (CC) late endosome 0.03745 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.1555Least InformativeInherited
Disease Ontology (DO)lung disease0.001103Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.9207Moderately InformativeInherited
Disease Ontology (DO)rheumatic disease0.004423InformativeInherited
Disease Ontology (DO)collagen disease0.1024InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.1339Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdomen0.3875Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.02668Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genital system0.1795Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.2024Moderately InformativeInherited
Phenotypic Abnormality (PA)Generalized abnormality of skin0.4582Moderately InformativeInherited
Phenotypic Abnormality (PA)Vascular skin abnormality0.0001963InformativeDirect
Phenotypic Abnormality (PA)Hernia0.01913InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal wall0.02254InformativeInherited
Phenotypic Abnormality (PA)Abnormality of female internal genitalia0.02346InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the pulmonary artery0.0001041Highly InformativeDirect
Phenotypic Abnormality (PA)Inguinal hernia0.0009242Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.01144Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.01824Least InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.001127Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal tumor incidence0.005615Moderately InformativeInherited
Mammalian Phenotype (MP)muscle phenotype0.007365Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.06037Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.06907Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.2383Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.2996Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.4032Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.4156Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.6429Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryogenesis/ development1Moderately InformativeInherited
Mammalian Phenotype (MP)increased malignant tumor incidence0.000564InformativeDirect
Mammalian Phenotype (MP)abnormal angiogenesis0.0006366InformativeDirect
Mammalian Phenotype (MP)abnormal preimplantation embryo development0.00544InformativeInherited
Mammalian Phenotype (MP)increased apoptosis0.0982InformativeInherited
Mammalian Phenotype (MP)abnormal developmental patterning0.1536InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial development0.1803InformativeInherited
Mammalian Phenotype (MP)abnormal sex determination0.4975InformativeInherited
Mammalian Phenotype (MP)abnormal embryonic epiblast morphology6.906e-07Highly InformativeDirect
Mammalian Phenotype (MP)abnormal primitive streak morphology2.266e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mesoderm development8.252e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pharyngeal arch artery morphology0.0003618Highly InformativeDirect
Mammalian Phenotype (MP)abnormal secondary sex determination0.0007757Highly InformativeDirect
Mammalian Phenotype (MP)abnormal embryonic-extraembryonic boundary morphology0.0008765Highly InformativeDirect
Mammalian Phenotype (MP)dilated cardiomyopathy0.0009934Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.3694Least InformativeInherited
Worm Phenotype (WP)lipid metabolism variant0.0004889InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect
Fly Phenotype (FP)lethal - all die before end of P-stage0Moderately InformativeDirect
Fly Phenotype (FP)wild-type5.677e-05InformativeDirect
Fly Phenotype (FP)size defective0.0003944InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0.07845Least InformativeInherited
Fly Anatomy (FA)anatomical group0.09298Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.1238Least InformativeInherited
Fly Anatomy (FA)cell0.2199Least InformativeInherited
Fly Anatomy (FA)larva0.4522Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)appendage0.00642Moderately InformativeInherited
Fly Anatomy (FA)adult thorax0.008007Moderately InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument0.01014Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.01075Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment0.01245Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.01735Moderately InformativeInherited
Fly Anatomy (FA)developing material anatomical entity0.053Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.06166Moderately InformativeInherited
Fly Anatomy (FA)reproductive system0.1908Moderately InformativeInherited
Fly Anatomy (FA)epithelium0.4982Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.5252Moderately InformativeInherited
Fly Anatomy (FA)germline stem cell9.325e-05InformativeDirect
Fly Anatomy (FA)cell component0.0006474InformativeDirect
Fly Anatomy (FA)tracheal system0.001372InformativeInherited
Fly Anatomy (FA)male germline cell0.002189InformativeInherited
Fly Anatomy (FA)wing blade0.005003InformativeInherited
Fly Anatomy (FA)male reproductive system0.005887InformativeInherited
Fly Anatomy (FA)ovariole0.05263InformativeInherited
Fly Anatomy (FA)male germline stem cell2.372e-06Highly InformativeDirect
Fly Anatomy (FA)female germline stem cell2.43e-05Highly InformativeDirect
Fly Anatomy (FA)epithelial furrow0.0002833Highly InformativeDirect
Fly Anatomy (FA)neuromuscular junction0.002659Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)trunk0Least InformativeDirect
Zebrafish Anatomy (ZA)portion of tissue0Least InformativeDirect
Zebrafish Anatomy (ZA)multi-tissue structure0Least InformativeDirect
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)surface structure0Moderately InformativeDirect
Zebrafish Anatomy (ZA)anatomical space0Moderately InformativeDirect
Zebrafish Anatomy (ZA)heart rudiment6.766e-06InformativeDirect
Zebrafish Anatomy (ZA)ventral fin fold3.798e-05InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)anatomical direction0.000858InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis1.224e-05Moderately InformativeDirect
Biological processCytolysis0InformativeDirect
Biological processGrowth regulation8.216e-12Highly InformativeDirect
Cellular componentMembrane1Least InformativeInherited
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCell membrane6.232e-07Moderately InformativeDirect
Cellular componentCell junction0.6765Moderately InformativeInherited
Cellular componentGPI-anchor0InformativeDirect
Cellular componentTight junction9.977e-07Highly InformativeDirect
DiseaseDisease mutation0.000374Least InformativeDirect
DomainSignal0Least InformativeDirect
Molecular functionManganese6.429e-13Moderately InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationKinase2.181e-05Moderately InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationToxin0InformativeDirect
Post-translational modificationNeurotoxin0Highly InformativeDirect
Post-translational modificationIon channel impairing toxin6.121e-08Highly InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect

Document: KW annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 42 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Snake toxin-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 42 hidden Markov models representing the Snake toxin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]