SUPERFAMILY 1.75 HMM library and genome assignments server

Snake toxin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Snake toxin-like [ 57301]
Superfamily:   Snake toxin-like [ 57302] (3)
Families:   Snake venom toxins [ 57303] (27)
  Dendroaspin [ 57351]
  Extracellular domain of cell surface receptors [ 57354] (6)


Superfamily statistics
Genomes (140) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 3,973 5,624 76
Proteins 3,634 5,116 68


Functional annotation
General category Processes_EC
Detailed category Toxins/defense

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process0.000000032110.0004324Least InformativeDirect
Biological Process (BP)regulation of metabolic process10.2104Least InformativeInherited
Biological Process (BP)developmental process0.040370Least InformativeInherited
Biological Process (BP)localization0.51610.01789Least InformativeInherited
Biological Process (BP)single-organism cellular process0.82270.000000046Least InformativeInherited
Biological Process (BP)multicellular organismal process0.014210Least InformativeInherited
Biological Process (BP)multi-organism process0.00000077110.00000000009209Moderately InformativeDirect
Biological Process (BP)anatomical structure morphogenesis0.22910.0005383Moderately InformativeInherited
Biological Process (BP)tissue development0.037620.00000000001333Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.66880.0856Moderately InformativeInherited
Biological Process (BP)cellular localization0.12611Moderately InformativeInherited
Biological Process (BP)organic substance transport0.12960.5139Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.28930.135Moderately InformativeInherited
Biological Process (BP)organ development0.14890.00001203Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.00079160.1543Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.065621Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.0059160.02318Moderately InformativeInherited
Biological Process (BP)organic hydroxy compound transport0.000061550.00005305InformativeDirect
Biological Process (BP)tissue morphogenesis0.00021480.0000000006436InformativeDirect
Biological Process (BP)cardiovascular system development0.00022280.00000000000005988InformativeDirect
Biological Process (BP)negative regulation of response to stimulus0.020540.09145InformativeInherited
Biological Process (BP)secretion by cell0.00039890.1209InformativeInherited
Biological Process (BP)regulation of immune response0.28890.8739InformativeInherited
Biological Process (BP)regulation of immune effector process0.000000010060.3043InformativeInherited
Biological Process (BP)growth0.014890.0000000009932InformativeInherited
Biological Process (BP)regulation of response to external stimulus0.06880.7654InformativeInherited
Biological Process (BP)regulation of hormone levels0.014610.1486InformativeInherited
Biological Process (BP)negative regulation of immune system process0.00011450.01075InformativeInherited
Biological Process (BP)negative regulation of protein processing0.2150.09825InformativeInherited
Biological Process (BP)regulation of response to wounding0.000000050470.02635InformativeInherited
Biological Process (BP)regulation of defense response0.0000015170.1433InformativeInherited
Biological Process (BP)embryo development ending in birth or egg hatching0.0000069640.00557InformativeInherited
Biological Process (BP)in utero embryonic development0.00000040770.00003804Highly InformativeDirect
Biological Process (BP)regulation of acute inflammatory response0.00000000000022510.00000001275Highly InformativeDirect
Biological Process (BP)regulation of humoral immune response0.00000000000032920.00002358Highly InformativeDirect
Biological Process (BP)hormone transport0.0000018340.000006052Highly InformativeDirect
Biological Process (BP)endocrine system development0.0000014630.0001312Highly InformativeDirect
Biological Process (BP)negative regulation of immune response0.000044490.000001143Highly InformativeDirect
Biological Process (BP)signal release0.000016170.1567Highly InformativeInherited
Biological Process (BP)negative regulation of immune effector process0.00014690.02755Highly InformativeInherited
Cellular Component (CC)membrane0.023230Least InformativeInherited
Cellular Component (CC)plasma membrane part0.0000094650Moderately InformativeDirect
Cellular Component (CC)cell surface0.0000000000064670InformativeDirect
Cellular Component (CC)side of membrane0.0000030490.0004372InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0.000000006746 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.00001531 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.000000046 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.0004324 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.3194 Least Informative Inherited
Biological Process (BP) localization 0.01789 Least Informative Inherited
Biological Process (BP) positive regulation of biological process 0.154 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.2104 Least Informative Inherited
Biological Process (BP) cellular protein modification process 0 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0.00000000000005988 Moderately Informative Direct
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.0005383 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0 Moderately Informative Direct
Biological Process (BP) tissue development 0.00000000001333 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.0000000000008913 Moderately Informative Direct
Biological Process (BP) reproductive process 0.000000000000007248 Moderately Informative Direct
Biological Process (BP) cell differentiation 0 Moderately Informative Direct
Biological Process (BP) organ development 0.00001203 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.00000002023 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.00000000007905 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.00000000009209 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.0001025 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.5507 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.02594 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.8442 Moderately Informative Inherited
Biological Process (BP) immune system process 0.01732 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.008625 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.06589 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.04742 Moderately Informative Inherited
Biological Process (BP) defense response 0.06363 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.2843 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.215 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.0856 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.5139 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.969 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.5025 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.5912 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.135 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.7941 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.02318 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.9756 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.1543 Moderately Informative Inherited
Biological Process (BP) regulation of phosphorus metabolic process 0.2164 Moderately Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.00000001982 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.0000006904 Informative Direct
Biological Process (BP) apoptotic process 0.0008581 Informative Direct
Biological Process (BP) cellular component movement 0.0000002372 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0 Informative Direct
Biological Process (BP) sensory organ development 0.00000005577 Informative Direct
Biological Process (BP) organ morphogenesis 0.0000000005092 Informative Direct
Biological Process (BP) lipid localization 0.00001619 Informative Direct
Biological Process (BP) organic hydroxy compound transport 0.00005305 Informative Direct
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.00000000005596 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 0.000001536 Informative Direct
Biological Process (BP) tube development 0.00000002202 Informative Direct
Biological Process (BP) growth 0.0000000009932 Informative Direct
Biological Process (BP) regulation of growth 0.00000001023 Informative Direct
Biological Process (BP) locomotion 0.0000000003427 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.00009461 Informative Direct
Biological Process (BP) single organism reproductive process 0.000000002803 Informative Direct
Biological Process (BP) embryonic morphogenesis 0.000000002771 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.0001036 Informative Direct
Biological Process (BP) generation of neurons 0.0004133 Informative Direct
Biological Process (BP) tissue morphogenesis 0.0000000006436 Informative Direct
Biological Process (BP) positive regulation of developmental process 0.0000000000004052 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.00000988 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0 Informative Direct
Biological Process (BP) localization of cell 0.0000002661 Informative Direct
Biological Process (BP) cardiovascular system development 0.00000000000005988 Informative Direct
Biological Process (BP) hematopoietic or lymphoid organ development 0.2311 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.09145 Informative Inherited
Biological Process (BP) gland development 0.001323 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.00557 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.8101 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.01651 Informative Inherited
Biological Process (BP) response to bacterium 0.327 Informative Inherited
Biological Process (BP) defense response to other organism 0.004918 Informative Inherited
Biological Process (BP) synaptic transmission 0.3967 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.04113 Informative Inherited
Biological Process (BP) secretion by cell 0.1209 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.02478 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.0117 Informative Inherited
Biological Process (BP) negative regulation of transport 0.1226 Informative Inherited
Biological Process (BP) regulation of secretion 0.02761 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.3504 Informative Inherited
Biological Process (BP) regulation of cell activation 0.08302 Informative Inherited
Biological Process (BP) regulation of immune response 0.8739 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.3043 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.07176 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.02603 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.001391 Informative Inherited
Biological Process (BP) response to organonitrogen compound 1 Informative Inherited
Biological Process (BP) regulation of transferase activity 0.1623 Informative Inherited
Biological Process (BP) sexual reproduction 0.03094 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.7654 Informative Inherited
Biological Process (BP) regulation of locomotion 0.044 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.001321 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) cell division 0.001807 Informative Inherited
Biological Process (BP) cell projection organization 0.1395 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.001324 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.1486 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 0.1597 Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.01075 Informative Inherited
Biological Process (BP) epithelium development 0.7658 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.003201 Informative Inherited
Biological Process (BP) response to nutrient levels 0.005296 Informative Inherited
Biological Process (BP) negative regulation of protein processing 0.09825 Informative Inherited
Biological Process (BP) regulation of defense response 0.1433 Informative Inherited
Biological Process (BP) regulation of response to wounding 0.02635 Informative Inherited
Biological Process (BP) leukocyte activation 0.1564 Informative Inherited
Biological Process (BP) skeletal system development 0.00000000003822 Highly Informative Direct
Biological Process (BP) angiogenesis 0.00001042 Highly Informative Direct
Biological Process (BP) in utero embryonic development 0.00003804 Highly Informative Direct
Biological Process (BP) myeloid leukocyte activation 0.00004965 Highly Informative Direct
Biological Process (BP) regulation of acute inflammatory response 0.00000001275 Highly Informative Direct
Biological Process (BP) regulation of humoral immune response 0.00002358 Highly Informative Direct
Biological Process (BP) protein phosphorylation 0 Highly Informative Direct
Biological Process (BP) germ cell development 0.0002099 Highly Informative Direct
Biological Process (BP) pattern specification process 0 Highly Informative Direct
Biological Process (BP) hormone transport 0.000006052 Highly Informative Direct
Biological Process (BP) cell growth 0.000002076 Highly Informative Direct
Biological Process (BP) respiratory tube development 0.0000001023 Highly Informative Direct
Biological Process (BP) neuron projection development 0.0003295 Highly Informative Direct
Biological Process (BP) endocrine system development 0.0001312 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0.00000004577 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 0.0008338 Highly Informative Direct
Biological Process (BP) positive regulation of growth 0 Highly Informative Direct
Biological Process (BP) developmental growth 0.00002618 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0.0001172 Highly Informative Direct
Biological Process (BP) stem cell development 0.00000000001679 Highly Informative Direct
Biological Process (BP) negative regulation of immune response 0.000001143 Highly Informative Direct
Biological Process (BP) regulation of T cell activation 0.00002475 Highly Informative Direct
Biological Process (BP) maintenance of location 0.0001738 Highly Informative Direct
Biological Process (BP) retina development in camera-type eye 0.00009971 Highly Informative Direct
Biological Process (BP) mesenchyme development 0.0000001508 Highly Informative Direct
Biological Process (BP) respiratory system development 0.0000000001668 Highly Informative Direct
Biological Process (BP) connective tissue development 0.0000001052 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 0 Highly Informative Direct
Biological Process (BP) regulation of peptide transport 0.0001897 Highly Informative Direct
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.00002301 Highly Informative Direct
Biological Process (BP) cell-type specific apoptotic process 0.002949 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 0.06027 Highly Informative Inherited
Biological Process (BP) negative regulation of secretion by cell 0.003111 Highly Informative Inherited
Biological Process (BP) defense response to bacterium 0.08399 Highly Informative Inherited
Biological Process (BP) cell projection morphogenesis 0.6461 Highly Informative Inherited
Biological Process (BP) signal release 0.1567 Highly Informative Inherited
Biological Process (BP) cell fate commitment 0.01706 Highly Informative Inherited
Biological Process (BP) regulation of hormone secretion 0.02076 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.1045 Highly Informative Inherited
Biological Process (BP) positive regulation of cell activation 0.01154 Highly Informative Inherited
Biological Process (BP) response to carbohydrate 0.01881 Highly Informative Inherited
Biological Process (BP) response to peptide hormone 0.008785 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 0.7528 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.09392 Highly Informative Inherited
Biological Process (BP) regulation of cell adhesion 0.003589 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.02565 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.001499 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.9524 Highly Informative Inherited
Biological Process (BP) chemotaxis 0.6107 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 0.3454 Highly Informative Inherited
Biological Process (BP) columnar/cuboidal epithelial cell differentiation 0.01665 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.4134 Highly Informative Inherited
Biological Process (BP) regulation of organ morphogenesis 0.01254 Highly Informative Inherited
Biological Process (BP) negative regulation of immune effector process 0.02755 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.1967 Highly Informative Inherited
Biological Process (BP) branching morphogenesis of an epithelial tube 0.06086 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.002674 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.05806 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.02016 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 0.09432 Moderately Informative Inherited
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0 Informative Direct
Molecular Function (MF) protein complex binding 0.000000001535 Informative Direct
Molecular Function (MF) purine ribonucleoside binding 0.0001868 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.000122 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) nucleotide binding 0.00284 Informative Inherited
Molecular Function (MF) protein kinase activity 0 Highly Informative Direct
Molecular Function (MF) transmembrane signaling receptor activity 0.0004971 Highly Informative Direct
Molecular Function (MF) ATP binding 0.000004912 Highly Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) protein complex 0.1999 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intrinsic component of membrane 0.0002908 Moderately Informative Direct
Cellular Component (CC) plasma membrane part 0 Moderately Informative Direct
Cellular Component (CC) transferase complex 0.000000008468 Moderately Informative Direct
Cellular Component (CC) cell projection 0.08538 Moderately Informative Inherited
Cellular Component (CC) membrane region 0.9054 Moderately Informative Inherited
Cellular Component (CC) endosome 0.000003678 Informative Direct
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) intrinsic component of plasma membrane 0.000000001081 Informative Direct
Cellular Component (CC) side of membrane 0.0004372 Informative Direct
Cellular Component (CC) integral component of membrane 0.00137 Informative Inherited
Cellular Component (CC) plasma membrane region 0.1294 Informative Inherited
Cellular Component (CC) integral component of plasma membrane 0.00000005845 Highly Informative Direct
Cellular Component (CC) receptor complex 0 Highly Informative Direct
Cellular Component (CC) late endosome 0.03949 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.1449Least InformativeInherited
Disease Ontology (DO)obstructive lung disease0.0001758Moderately InformativeDirect
Disease Ontology (DO)connective tissue disease0.0441Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.9224Moderately InformativeInherited
Disease Ontology (DO)rheumatic disease0.005129InformativeInherited
Disease Ontology (DO)collagen disease0.005723InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the abdomen0.3866Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.02571Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal genital system morphology0.06Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.2015Moderately InformativeInherited
Phenotypic Abnormality (PA)Generalized abnormality of skin0.4575Moderately InformativeInherited
Phenotypic Abnormality (PA)Vascular skin abnormality0.0001909InformativeDirect
Phenotypic Abnormality (PA)Hernia0.01922InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal wall0.02214InformativeInherited
Phenotypic Abnormality (PA)Abnormality of female internal genitalia0.02532InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the pulmonary artery0.0001018Highly InformativeDirect
Phenotypic Abnormality (PA)Inguinal hernia0.0009215Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.008352Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.01056Least InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.000437Moderately InformativeDirect
Mammalian Phenotype (MP)tumorigenesis0.01316Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.04675Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.1557Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.3487Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.3627Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.3798Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.6122Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryogenesis/ development1Moderately InformativeInherited
Mammalian Phenotype (MP)increased malignant tumor incidence0.0008415InformativeDirect
Mammalian Phenotype (MP)abnormal extraembryonic tissue morphology0.001622InformativeInherited
Mammalian Phenotype (MP)abnormal systemic artery morphology0.07964InformativeInherited
Mammalian Phenotype (MP)increased apoptosis0.08974InformativeInherited
Mammalian Phenotype (MP)abnormal developmental patterning0.09097InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial development0.1857InformativeInherited
Mammalian Phenotype (MP)abnormal angiogenesis0.2065InformativeInherited
Mammalian Phenotype (MP)abnormal sex determination0.3337InformativeInherited
Mammalian Phenotype (MP)abnormal embryonic epiblast morphology0.00000002265Highly InformativeDirect
Mammalian Phenotype (MP)abnormal primitive streak morphology0.000001628Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mesoderm development0.000007021Highly InformativeDirect
Mammalian Phenotype (MP)abnormal embryonic-extraembryonic boundary morphology0.00007871Highly InformativeDirect
Mammalian Phenotype (MP)abnormal aortic arch morphology0.0002715Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pharyngeal arch artery morphology0.000485Highly InformativeDirect
Mammalian Phenotype (MP)abnormal secondary sex determination0.0009187Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.3694Least InformativeInherited
Worm Phenotype (WP)lipid metabolism variant0.0004889InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect
Fly Phenotype (FP)lethal - all die before end of P-stage0Moderately InformativeDirect
Fly Phenotype (FP)wild-type0.00005464InformativeDirect
Fly Phenotype (FP)size defective0.0003901InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0.07846Least InformativeInherited
Fly Anatomy (FA)anatomical group0.0899Least InformativeInherited
Fly Anatomy (FA)adult0.09409Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.1215Least InformativeInherited
Fly Anatomy (FA)cell0.2144Least InformativeInherited
Fly Anatomy (FA)larva0.4491Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)appendage0.006605Moderately InformativeInherited
Fly Anatomy (FA)adult thorax0.008226Moderately InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument0.01027Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.01086Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment0.01261Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.01781Moderately InformativeInherited
Fly Anatomy (FA)developing material anatomical entity0.05168Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.05919Moderately InformativeInherited
Fly Anatomy (FA)reproductive system0.1874Moderately InformativeInherited
Fly Anatomy (FA)epithelium0.497Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.5201Moderately InformativeInherited
Fly Anatomy (FA)germline stem cell0.00009312InformativeDirect
Fly Anatomy (FA)cell component0.0004569InformativeDirect
Fly Anatomy (FA)tracheal system0.001365InformativeInherited
Fly Anatomy (FA)male germline cell0.002105InformativeInherited
Fly Anatomy (FA)wing blade0.004949InformativeInherited
Fly Anatomy (FA)male reproductive system0.005713InformativeInherited
Fly Anatomy (FA)ovariole0.05191InformativeInherited
Fly Anatomy (FA)male germline stem cell0.000002364Highly InformativeDirect
Fly Anatomy (FA)female germline stem cell0.00002427Highly InformativeDirect
Fly Anatomy (FA)epithelial furrow0.0002835Highly InformativeDirect
Fly Anatomy (FA)neuromuscular junction0.003007Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)trunk0Least InformativeDirect
Zebrafish Anatomy (ZA)portion of tissue0Least InformativeDirect
Zebrafish Anatomy (ZA)multi-tissue structure0Least InformativeDirect
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)anatomical space0Moderately InformativeDirect
Zebrafish Anatomy (ZA)heart rudiment0.000006463InformativeDirect
Zebrafish Anatomy (ZA)ventral fin fold0.00003737InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)anatomical direction0.0009105InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0.00001224Moderately InformativeDirect
Biological processCytolysis0InformativeDirect
Biological processGrowth regulation0.000000000008132Highly InformativeDirect
Cellular componentMembrane1Least InformativeInherited
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCell membrane0.0000007048Moderately InformativeDirect
Cellular componentCell junction0.6773Moderately InformativeInherited
Cellular componentGPI-anchor0InformativeDirect
Cellular componentTight junction0.0000009954Highly InformativeDirect
DiseaseDisease mutation0.000398Least InformativeDirect
DomainSignal0Least InformativeDirect
Molecular functionManganese0.0000000000007775Moderately InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationKinase0.00002207Moderately InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationToxin0InformativeDirect
Post-translational modificationNeurotoxin0Highly InformativeDirect
Post-translational modificationIon channel impairing toxin0.00000006085Highly InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect

Document: KW annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 42 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Snake toxin-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 42 hidden Markov models representing the Snake toxin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]