SUPERFAMILY 1.75 HMM library and genome assignments server


Snake toxin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Snake toxin-like [ 57301]
Superfamily:   Snake toxin-like [ 57302] (3)
Families:   Snake venom toxins [ 57303] (27)
  Dendroaspin [ 57351]
  Extracellular domain of cell surface receptors [ 57354] (6)


Superfamily statistics
Genomes (136) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 3,693 5,624 76
Proteins 3,391 5,116 68


Functional annotation
General category Processes_EC
Detailed category Toxins/defense

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process6.182e-080.0003774Least InformativeDirect
Biological Process (BP)regulation of metabolic process10.06787Least InformativeInherited
Biological Process (BP)localization0.43510.00698Least InformativeInherited
Biological Process (BP)developmental process0.030520Least InformativeInherited
Biological Process (BP)multicellular organismal process0.032320Least InformativeInherited
Biological Process (BP)multi-organism process1.783e-060.0002242Moderately InformativeDirect
Biological Process (BP)negative regulation of metabolic process0.0048541Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.00015950.06263Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.0016670.3052Moderately InformativeInherited
Biological Process (BP)organ development0.15337.733e-07Moderately InformativeInherited
Biological Process (BP)tissue development0.0065021.69e-10Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.2220.0005194Moderately InformativeInherited
Biological Process (BP)organic substance transport0.12170.4717Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.35750.0642Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.020860Moderately InformativeInherited
Biological Process (BP)cardiovascular system development0.00021653.424e-14InformativeDirect
Biological Process (BP)tissue morphogenesis0.0004714.173e-09InformativeDirect
Biological Process (BP)gland development0.00052170.0005061InformativeDirect
Biological Process (BP)growth0.0041661.158e-07InformativeInherited
Biological Process (BP)regulation of immune effector process7.711e-090.3018InformativeInherited
Biological Process (BP)muscle tissue development0.0042740.9357InformativeInherited
Biological Process (BP)regulation of hormone levels0.0066730.07953InformativeInherited
Biological Process (BP)negative regulation of response to stimulus0.021620.1149InformativeInherited
Biological Process (BP)regulation of immune response0.23940.752InformativeInherited
Biological Process (BP)regulation of response to external stimulus0.033770.3166InformativeInherited
Biological Process (BP)regulation of response to stress0.27550.9939InformativeInherited
Biological Process (BP)negative regulation of protein metabolic process0.0012730.8025InformativeInherited
Biological Process (BP)embryo development ending in birth or egg hatching5.785e-060.007624InformativeInherited
Biological Process (BP)regulation of acute inflammatory response1.692e-131.045e-08Highly InformativeDirect
Biological Process (BP)regulation of humoral immune response3.032e-132.702e-05Highly InformativeDirect
Biological Process (BP)regulation of protein processing9.913e-135.678e-05Highly InformativeDirect
Biological Process (BP)pathogenesis2.506e-094.41e-05Highly InformativeDirect
Biological Process (BP)endocrine system development1.507e-060.0001257Highly InformativeDirect
Biological Process (BP)hormone transport1.889e-065.191e-06Highly InformativeDirect
Biological Process (BP)negative regulation of immune system process3.325e-060.000256Highly InformativeDirect
Biological Process (BP)organic hydroxy compound transport3.601e-051.899e-05Highly InformativeDirect
Cellular Component (CC)membrane0.010190Least InformativeInherited
Cellular Component (CC)plasma membrane2.218e-050Moderately InformativeDirect
Cellular Component (CC)cell surface1.755e-120InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 0.0003774 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 2.434e-14 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) protein metabolic process 1.69e-09 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 5.985e-06 Least Informative Direct
Biological Process (BP) localization 0.00698 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.1751 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.06787 Least Informative Inherited
Biological Process (BP) multi-organism process 0.0002242 Moderately Informative Direct
Biological Process (BP) tissue development 1.69e-10 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 0 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0 Moderately Informative Direct
Biological Process (BP) reproduction 3.959e-12 Moderately Informative Direct
Biological Process (BP) organ development 7.733e-07 Moderately Informative Direct
Biological Process (BP) cell differentiation 0 Moderately Informative Direct
Biological Process (BP) response to organic substance 2.571e-12 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.0005194 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 5.546e-15 Moderately Informative Direct
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 3.722e-15 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 2.822e-09 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 3.241e-06 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.4198 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.0642 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.1804 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.04323 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.1712 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.7458 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.4717 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.01609 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.01797 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.00241 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.8123 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 0.541 Moderately Informative Inherited
Biological Process (BP) immune system process 0.01257 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.3052 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.3299 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.06263 Moderately Informative Inherited
Biological Process (BP) cardiovascular system development 3.424e-14 Informative Direct
Biological Process (BP) tissue morphogenesis 4.173e-09 Informative Direct
Biological Process (BP) gland development 0.0005061 Informative Direct
Biological Process (BP) growth 1.158e-07 Informative Direct
Biological Process (BP) organ morphogenesis 5.687e-09 Informative Direct
Biological Process (BP) developmental process involved in reproduction 0.0002631 Informative Direct
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0 Informative Direct
Biological Process (BP) positive regulation of developmental process 9.175e-14 Informative Direct
Biological Process (BP) regulation of growth 4.041e-13 Informative Direct
Biological Process (BP) locomotion 1.599e-10 Informative Direct
Biological Process (BP) positive regulation of protein modification process 1.675e-10 Informative Direct
Biological Process (BP) tube development 1.869e-10 Informative Direct
Biological Process (BP) regulation of protein phosphorylation 7.717e-09 Informative Direct
Biological Process (BP) single organism reproductive process 1.119e-08 Informative Direct
Biological Process (BP) cellular process involved in reproduction 1.358e-08 Informative Direct
Biological Process (BP) embryonic morphogenesis 2.972e-08 Informative Direct
Biological Process (BP) sensory organ development 3.246e-07 Informative Direct
Biological Process (BP) localization of cell 3.702e-07 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 4.344e-07 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 4.727e-06 Informative Direct
Biological Process (BP) cellular component movement 5.277e-06 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 7.116e-06 Informative Direct
Biological Process (BP) lipid localization 1.17e-05 Informative Direct
Biological Process (BP) response to wounding 2.143e-05 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 2.782e-05 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 6.879e-05 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 7.277e-05 Informative Direct
Biological Process (BP) negative regulation of developmental process 0.0001185 Informative Direct
Biological Process (BP) generation of neurons 0.0002628 Informative Direct
Biological Process (BP) programmed cell death 0.001995 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.2764 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.3777 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.004454 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) regulation of secretion 0.02514 Informative Inherited
Biological Process (BP) defense response 0.08308 Informative Inherited
Biological Process (BP) response to other organism 1 Informative Inherited
Biological Process (BP) transmission of nerve impulse 0.2828 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.05445 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.6094 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.3201 Informative Inherited
Biological Process (BP) leukocyte activation 0.1573 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.002623 Informative Inherited
Biological Process (BP) sexual reproduction 0.002918 Informative Inherited
Biological Process (BP) regulation of kinase activity 1 Informative Inherited
Biological Process (BP) response to organonitrogen compound 1 Informative Inherited
Biological Process (BP) response to hormone stimulus 1 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.3018 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.01238 Informative Inherited
Biological Process (BP) regulation of locomotion 0.03336 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) cell projection organization 0.2986 Informative Inherited
Biological Process (BP) muscle tissue development 0.9357 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.1131 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.04967 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.07953 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.7862 Informative Inherited
Biological Process (BP) regulation of cell development 0.8076 Informative Inherited
Biological Process (BP) cell-cell signaling 0.653 Informative Inherited
Biological Process (BP) protein complex assembly 0.1693 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 0.1929 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.1149 Informative Inherited
Biological Process (BP) regulation of immune response 0.752 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.3166 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.8025 Informative Inherited
Biological Process (BP) regulation of response to stress 0.9939 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.007624 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.0391 Informative Inherited
Biological Process (BP) regulation of acute inflammatory response 1.045e-08 Highly Informative Direct
Biological Process (BP) regulation of humoral immune response 2.702e-05 Highly Informative Direct
Biological Process (BP) regulation of protein processing 5.678e-05 Highly Informative Direct
Biological Process (BP) pathogenesis 4.41e-05 Highly Informative Direct
Biological Process (BP) endocrine system development 0.0001257 Highly Informative Direct
Biological Process (BP) hormone transport 5.191e-06 Highly Informative Direct
Biological Process (BP) negative regulation of immune system process 0.000256 Highly Informative Direct
Biological Process (BP) organic hydroxy compound transport 1.899e-05 Highly Informative Direct
Biological Process (BP) protein phosphorylation 0 Highly Informative Direct
Biological Process (BP) regulation of striated muscle tissue development 0 Highly Informative Direct
Biological Process (BP) pattern specification process 0 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 0 Highly Informative Direct
Biological Process (BP) positive regulation of growth 0 Highly Informative Direct
Biological Process (BP) stem cell development 5.711e-13 Highly Informative Direct
Biological Process (BP) respiratory system development 1.421e-10 Highly Informative Direct
Biological Process (BP) skeletal system development 1.889e-08 Highly Informative Direct
Biological Process (BP) mesenchyme development 4.922e-08 Highly Informative Direct
Biological Process (BP) respiratory tube development 2.912e-07 Highly Informative Direct
Biological Process (BP) cell division 3.539e-06 Highly Informative Direct
Biological Process (BP) cellular process involved in reproduction in multicellular organism 5.403e-06 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 1.538e-05 Highly Informative Direct
Biological Process (BP) connective tissue development 1.755e-05 Highly Informative Direct
Biological Process (BP) regulation of T cell activation 1.913e-05 Highly Informative Direct
Biological Process (BP) regulation of multicellular organism growth 2.109e-05 Highly Informative Direct
Biological Process (BP) positive regulation of cell differentiation 2.795e-05 Highly Informative Direct
Biological Process (BP) angiogenesis 3.361e-05 Highly Informative Direct
Biological Process (BP) myeloid leukocyte activation 4.807e-05 Highly Informative Direct
Biological Process (BP) regulation of peptide transport 5.724e-05 Highly Informative Direct
Biological Process (BP) negative regulation of secretion 6.596e-05 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 6.933e-05 Highly Informative Direct
Biological Process (BP) retina development in camera-type eye 0.0001105 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0.0007366 Highly Informative Direct
Biological Process (BP) cell-type specific apoptotic process 0.002618 Highly Informative Inherited
Biological Process (BP) cell growth 0.01009 Highly Informative Inherited
Biological Process (BP) developmental growth 0.01545 Highly Informative Inherited
Biological Process (BP) renal system development 0.01235 Highly Informative Inherited
Biological Process (BP) defense response to bacterium 0.03398 Highly Informative Inherited
Biological Process (BP) cell projection morphogenesis 0.647 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.01879 Highly Informative Inherited
Biological Process (BP) cell fate commitment 0.01971 Highly Informative Inherited
Biological Process (BP) regulation of hormone secretion 0.01028 Highly Informative Inherited
Biological Process (BP) regulation of innate immune response 0.1629 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.001352 Highly Informative Inherited
Biological Process (BP) positive regulation of cell activation 0.01614 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.1111 Highly Informative Inherited
Biological Process (BP) response to peptide hormone stimulus 0.01035 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 0.7881 Highly Informative Inherited
Biological Process (BP) regulation of cell adhesion 0.002159 Highly Informative Inherited
Biological Process (BP) response to carbohydrate stimulus 0.01302 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.003441 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in neuron differentiation 0.03374 Highly Informative Inherited
Biological Process (BP) chemotaxis 0.5428 Highly Informative Inherited
Biological Process (BP) axon development 0.7256 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 0.3759 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.3984 Highly Informative Inherited
Biological Process (BP) regulation of organ morphogenesis 0.01333 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.2031 Highly Informative Inherited
Biological Process (BP) branching morphogenesis of an epithelial tube 0.06279 Highly Informative Inherited
Molecular Function (MF) binding 0.0006095 Least Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.04543 Moderately Informative Inherited
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.000101 Informative Direct
Molecular Function (MF) purine ribonucleoside binding 0.0001545 Informative Direct
Molecular Function (MF) nucleotide binding 0.002194 Informative Inherited
Molecular Function (MF) protein kinase activity 0 Highly Informative Direct
Molecular Function (MF) protein complex binding 0 Highly Informative Direct
Molecular Function (MF) ATP binding 3.875e-06 Highly Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) protein complex 0.1667 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 0.0004711 Moderately Informative Direct
Cellular Component (CC) cell projection 0.2092 Moderately Informative Inherited
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) intrinsic to plasma membrane 4.208e-09 Informative Direct
Cellular Component (CC) endosome 2.304e-06 Informative Direct
Cellular Component (CC) integral to membrane 0.7476 Informative Inherited
Cellular Component (CC) integral to plasma membrane 2.253e-06 Highly Informative Direct
Cellular Component (CC) receptor complex 0 Highly Informative Direct
Cellular Component (CC) early endosome 0.0001593 Highly Informative Direct
Cellular Component (CC) membrane raft 0.06521 Highly Informative Inherited
Cellular Component (CC) late endosome 0.03714 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.1427Least InformativeInherited
Disease Ontology (DO)lung disease0.001108Moderately InformativeInherited
Disease Ontology (DO)musculoskeletal system disease0.2604Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.9193Moderately InformativeInherited
Disease Ontology (DO)connective tissue disease0.0008094InformativeDirect
Disease Ontology (DO)rheumatic disease0.00418InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the abdomen0.3879Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.02761Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal genital system morphology0.06026Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.2026Moderately InformativeInherited
Phenotypic Abnormality (PA)Generalized abnormality of skin0.4562Moderately InformativeInherited
Phenotypic Abnormality (PA)Vascular skin abnormality0.0002025InformativeDirect
Phenotypic Abnormality (PA)Hernia0.01966InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal wall0.02298InformativeInherited
Phenotypic Abnormality (PA)Abnormality of female internal genitalia0.02489InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the pulmonary artery0.000114Highly InformativeDirect
Phenotypic Abnormality (PA)Inguinal hernia0.0009468Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.01136Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.01837Least InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.001154Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal tumor incidence0.005692Moderately InformativeInherited
Mammalian Phenotype (MP)muscle phenotype0.007323Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.06006Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.06911Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.2382Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.2951Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.4015Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.4136Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryogenesis/ development1Moderately InformativeInherited
Mammalian Phenotype (MP)increased malignant tumor incidence0.0005769InformativeDirect
Mammalian Phenotype (MP)abnormal angiogenesis0.0006528InformativeDirect
Mammalian Phenotype (MP)abnormal preimplantation embryo development0.005376InformativeInherited
Mammalian Phenotype (MP)increased apoptosis0.09871InformativeInherited
Mammalian Phenotype (MP)abnormal developmental patterning0.156InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial development0.1809InformativeInherited
Mammalian Phenotype (MP)abnormal sex determination0.4995InformativeInherited
Mammalian Phenotype (MP)abnormal embryonic epiblast morphology7.082e-07Highly InformativeDirect
Mammalian Phenotype (MP)abnormal primitive streak morphology2.313e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mesoderm development8.431e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pharyngeal arch artery morphology0.0003661Highly InformativeDirect
Mammalian Phenotype (MP)abnormal secondary sex determination0.0007901Highly InformativeDirect
Mammalian Phenotype (MP)abnormal embryonic-extraembryonic boundary morphology0.0008966Highly InformativeDirect
Mammalian Phenotype (MP)dilated cardiomyopathy0.0009631Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.3694Least InformativeInherited
Worm Phenotype (WP)lipid metabolism variant0.0004889InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect
Fly Phenotype (FP)lethal - all die before end of P-stage0Moderately InformativeDirect
Fly Phenotype (FP)wild-type6.889e-05InformativeDirect
Fly Phenotype (FP)size defective0.0004173InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0.08508Least InformativeInherited
Fly Anatomy (FA)anatomical group0.1023Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.1341Least InformativeInherited
Fly Anatomy (FA)cell0.2325Least InformativeInherited
Fly Anatomy (FA)larva0.4559Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)appendage0.007913Moderately InformativeInherited
Fly Anatomy (FA)adult thorax0.009732Moderately InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument0.01252Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.01323Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment0.01501Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.02044Moderately InformativeInherited
Fly Anatomy (FA)portion of tissue0.02184Moderately InformativeInherited
Fly Anatomy (FA)developing material anatomical entity0.05644Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.06242Moderately InformativeInherited
Fly Anatomy (FA)reproductive system0.2087Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.5256Moderately InformativeInherited
Fly Anatomy (FA)germline stem cell0.0001096InformativeDirect
Fly Anatomy (FA)cell component0.0005482InformativeDirect
Fly Anatomy (FA)tracheal system0.001437InformativeInherited
Fly Anatomy (FA)male germline cell0.002318InformativeInherited
Fly Anatomy (FA)testis0.005453InformativeInherited
Fly Anatomy (FA)wing blade0.005776InformativeInherited
Fly Anatomy (FA)ovariole0.05807InformativeInherited
Fly Anatomy (FA)male germline stem cell2.572e-06Highly InformativeDirect
Fly Anatomy (FA)female germline stem cell2.918e-05Highly InformativeDirect
Fly Anatomy (FA)epithelial furrow0.0002596Highly InformativeDirect
Fly Anatomy (FA)neuromuscular junction0.002312Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)trunk0Least InformativeDirect
Zebrafish Anatomy (ZA)portion of tissue0Least InformativeDirect
Zebrafish Anatomy (ZA)multi-tissue structure0Least InformativeDirect
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)surface structure0Moderately InformativeDirect
Zebrafish Anatomy (ZA)anatomical space0Moderately InformativeDirect
Zebrafish Anatomy (ZA)heart rudiment6.448e-06InformativeDirect
Zebrafish Anatomy (ZA)ventral fin fold3.745e-05InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)embryo0.05256Least InformativeInherited
Xenopus ANatomical entity (XAN)visual system0.05604Moderately InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.09292Moderately InformativeInherited
Xenopus ANatomical entity (XAN)anatomical direction0.0008487InformativeDirect
Xenopus ANatomical entity (XAN)optic vesicle0.000958Highly InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis1.222e-05Moderately InformativeDirect
Biological processCytolysis0InformativeDirect
Biological processGrowth regulation8.207e-12Highly InformativeDirect
Cellular componentMembrane1Least InformativeInherited
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCell membrane5.46e-07Moderately InformativeDirect
Cellular componentCell junction0.6758Moderately InformativeInherited
Cellular componentGPI-anchor0InformativeDirect
Cellular componentTight junction9.975e-07Highly InformativeDirect
DiseaseDisease mutation0.0003741Least InformativeDirect
DomainSignal0Least InformativeDirect
Molecular functionManganese6.091e-13Moderately InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationKinase2.1e-05Moderately InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationToxin0InformativeDirect
Post-translational modificationNeurotoxin0Highly InformativeDirect
Post-translational modificationIon channel impairing toxin1.185e-07Highly InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect

Document: KW annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 42 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Snake toxin-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 42 hidden Markov models representing the Snake toxin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]