SUPERFAMILY 1.75 HMM library and genome assignments server


Snake toxin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Snake toxin-like [ 57301]
Superfamily:   Snake toxin-like [ 57302] (3)
Families:   Snake venom toxins [ 57303] (27)
  Dendroaspin [ 57351]
  Extracellular domain of cell surface receptors [ 57354] (6)


Superfamily statistics
Genomes (126) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 3,535 4,632 76
Proteins 3,240 4,186 68


Functional annotation
General category Processes_EC
Detailed category Toxins/defense

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)localization0.53210.01324Least InformativeInherited
Biological Process (BP)developmental process0.19420Least InformativeInherited
Biological Process (BP)multicellular organismal process0.10170Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.61030.00272Least InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.002351Moderately InformativeInherited
Biological Process (BP)tissue development0.013631.222e-08Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.064648.102e-06Moderately InformativeInherited
Biological Process (BP)organic substance transport0.13940.5549Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.064260Moderately InformativeInherited
Biological Process (BP)multi-organism process4.007e-060.01658Moderately InformativeInherited
Biological Process (BP)organ development0.042069.803e-07Moderately InformativeInherited
Biological Process (BP)regulation of response to stimulus0.013020.01069Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.0015620.05385Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.0099590.3563Moderately InformativeInherited
Biological Process (BP)tissue morphogenesis0.00011989.404e-11InformativeDirect
Biological Process (BP)cardiovascular system development0.00022020InformativeDirect
Biological Process (BP)gland development0.00034470.0002923InformativeDirect
Biological Process (BP)growth0.017612.006e-06InformativeInherited
Biological Process (BP)regulation of immune effector process2.205e-070.09691InformativeInherited
Biological Process (BP)muscle tissue development0.0014750.9364InformativeInherited
Biological Process (BP)regulation of hormone levels0.0080660.06426InformativeInherited
Biological Process (BP)negative regulation of response to stimulus3.294e-050.01072InformativeInherited
Biological Process (BP)regulation of immune response0.013221InformativeInherited
Biological Process (BP)regulation of response to external stimulus0.00080560.3169InformativeInherited
Biological Process (BP)negative regulation of protein metabolic process9.831e-060.7432InformativeInherited
Biological Process (BP)regulation of response to stress0.011961InformativeInherited
Biological Process (BP)chordate embryonic development3.431e-060.7581InformativeInherited
Biological Process (BP)regulation of protein processing6.794e-110.0001863Highly InformativeDirect
Biological Process (BP)pathogenesis4.128e-095.751e-06Highly InformativeDirect
Biological Process (BP)hormone transport2.116e-067.077e-06Highly InformativeDirect
Biological Process (BP)endocrine system development2.747e-060.0001146Highly InformativeDirect
Biological Process (BP)organic hydroxy compound transport3.286e-052.186e-05Highly InformativeDirect
Biological Process (BP)regulation of inflammatory response2.29e-070.002653Highly InformativeInherited
Biological Process (BP)negative regulation of immune system process1.261e-060.05619Highly InformativeInherited
Cellular Component (CC)membrane0.09060Least InformativeInherited
Cellular Component (CC)plasma membrane0.00039350Moderately InformativeDirect
Cellular Component (CC)cell surface1.877e-120InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 9.333e-05 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 2.882e-12 Least Informative Direct
Biological Process (BP) response to stimulus 9.754e-15 Least Informative Direct
Biological Process (BP) protein metabolic process 4.32e-08 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 6.487e-05 Least Informative Direct
Biological Process (BP) localization 0.01324 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.5557 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.00272 Least Informative Inherited
Biological Process (BP) tissue development 1.222e-08 Moderately Informative Direct
Biological Process (BP) regulation of signaling 7.795e-06 Moderately Informative Direct
Biological Process (BP) organ development 9.803e-07 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 7.916e-05 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 0 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 8.102e-06 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 2.798e-14 Moderately Informative Direct
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) cell differentiation 0 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 4.008e-15 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 1.53e-14 Moderately Informative Direct
Biological Process (BP) response to organic substance 2.364e-12 Moderately Informative Direct
Biological Process (BP) reproduction 2.292e-10 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 4.818e-07 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.05795 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.05837 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 0.2207 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.3679 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.04682 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.5549 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.01658 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.2395 Moderately Informative Inherited
Biological Process (BP) system process 0.9776 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.004774 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.001286 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.5399 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 0.8305 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 0.6369 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.01069 Moderately Informative Inherited
Biological Process (BP) immune system process 0.02506 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.3563 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.1477 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.05385 Moderately Informative Inherited
Biological Process (BP) tissue morphogenesis 9.404e-11 Informative Direct
Biological Process (BP) cardiovascular system development 0 Informative Direct
Biological Process (BP) gland development 0.0002923 Informative Direct
Biological Process (BP) organ morphogenesis 4.764e-11 Informative Direct
Biological Process (BP) growth 2.006e-06 Informative Direct
Biological Process (BP) protein phosphorylation 0 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0 Informative Direct
Biological Process (BP) positive regulation of developmental process 1.559e-11 Informative Direct
Biological Process (BP) tube development 1.563e-10 Informative Direct
Biological Process (BP) locomotion 3.743e-10 Informative Direct
Biological Process (BP) regulation of growth 5.147e-10 Informative Direct
Biological Process (BP) embryonic morphogenesis 1.359e-09 Informative Direct
Biological Process (BP) single organism reproductive process 2.196e-09 Informative Direct
Biological Process (BP) cellular process involved in reproduction 1.255e-08 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 3.952e-08 Informative Direct
Biological Process (BP) sensory organ development 4.308e-08 Informative Direct
Biological Process (BP) positive regulation of phosphorus metabolic process 1.262e-07 Informative Direct
Biological Process (BP) localization of cell 3.563e-07 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 6.223e-06 Informative Direct
Biological Process (BP) negative regulation of developmental process 9.188e-06 Informative Direct
Biological Process (BP) response to wounding 2.076e-05 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 5.141e-05 Informative Direct
Biological Process (BP) cellular component movement 6.863e-05 Informative Direct
Biological Process (BP) developmental process involved in reproduction 0.0001061 Informative Direct
Biological Process (BP) cell activation 0.000184 Informative Direct
Biological Process (BP) positive regulation of protein metabolic process 0.0002623 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.0002863 Informative Direct
Biological Process (BP) multicellular organismal reproductive process 0.000828 Informative Direct
Biological Process (BP) negative regulation of signaling 0.04747 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.07558 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.001985 Informative Inherited
Biological Process (BP) epithelium development 0.7875 Informative Inherited
Biological Process (BP) regulation of secretion 0.03341 Informative Inherited
Biological Process (BP) synaptic transmission 0.001119 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.6729 Informative Inherited
Biological Process (BP) regulation of cell development 0.7958 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.4393 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.001278 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.1243 Informative Inherited
Biological Process (BP) sexual reproduction 0.001148 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.06326 Informative Inherited
Biological Process (BP) regulation of kinase activity 1 Informative Inherited
Biological Process (BP) response to organic nitrogen 1 Informative Inherited
Biological Process (BP) response to hormone stimulus 1 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.09691 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.00769 Informative Inherited
Biological Process (BP) regulation of locomotion 0.02289 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) generation of neurons 0.002662 Informative Inherited
Biological Process (BP) cell projection organization 0.2845 Informative Inherited
Biological Process (BP) muscle tissue development 0.9364 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.04062 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.02699 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.06426 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.8967 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 0.1635 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.01072 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.3169 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.7432 Informative Inherited
Biological Process (BP) regulation of response to stress 1 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.00391 Informative Inherited
Biological Process (BP) chordate embryonic development 0.7581 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.02466 Informative Inherited
Biological Process (BP) regulation of protein processing 0.0001863 Highly Informative Direct
Biological Process (BP) pathogenesis 5.751e-06 Highly Informative Direct
Biological Process (BP) hormone transport 7.077e-06 Highly Informative Direct
Biological Process (BP) endocrine system development 0.0001146 Highly Informative Direct
Biological Process (BP) organic hydroxy compound transport 2.186e-05 Highly Informative Direct
Biological Process (BP) pattern specification process 0 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 0 Highly Informative Direct
Biological Process (BP) stem cell development 0 Highly Informative Direct
Biological Process (BP) positive regulation of growth 1.185e-11 Highly Informative Direct
Biological Process (BP) germ cell development 1.558e-08 Highly Informative Direct
Biological Process (BP) lung development 6.173e-08 Highly Informative Direct
Biological Process (BP) regulation of insulin secretion 1.858e-06 Highly Informative Direct
Biological Process (BP) activation of protein kinase activity 2.759e-06 Highly Informative Direct
Biological Process (BP) positive regulation of cell differentiation 4.814e-06 Highly Informative Direct
Biological Process (BP) cell division 7.338e-06 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 1.448e-05 Highly Informative Direct
Biological Process (BP) angiogenesis 1.551e-05 Highly Informative Direct
Biological Process (BP) skeletal system development 1.992e-05 Highly Informative Direct
Biological Process (BP) regulation of multicellular organism growth 2.073e-05 Highly Informative Direct
Biological Process (BP) retina development in camera-type eye 2.712e-05 Highly Informative Direct
Biological Process (BP) myeloid leukocyte activation 5.772e-05 Highly Informative Direct
Biological Process (BP) response to insulin stimulus 6.877e-05 Highly Informative Direct
Biological Process (BP) negative regulation of secretion 7.998e-05 Highly Informative Direct
Biological Process (BP) regulation of lymphocyte activation 0.0001331 Highly Informative Direct
Biological Process (BP) gastrulation 0.0005269 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.0008685 Highly Informative Direct
Biological Process (BP) cell growth 0.005076 Highly Informative Inherited
Biological Process (BP) developmental growth 0.005249 Highly Informative Inherited
Biological Process (BP) negative regulation of signal transduction 0.2407 Highly Informative Inherited
Biological Process (BP) connective tissue development 0.006875 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.00861 Highly Informative Inherited
Biological Process (BP) cell fate commitment 0.04379 Highly Informative Inherited
Biological Process (BP) positive regulation of cell activation 0.01031 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.09853 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.01766 Highly Informative Inherited
Biological Process (BP) regulation of inflammatory response 0.002653 Highly Informative Inherited
Biological Process (BP) regulation of cell adhesion 0.001199 Highly Informative Inherited
Biological Process (BP) regulation of stem cell proliferation 0.01457 Highly Informative Inherited
Biological Process (BP) response to carbohydrate stimulus 0.01228 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.001211 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 0.4128 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.3829 Highly Informative Inherited
Biological Process (BP) regulation of organ morphogenesis 0.004403 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.05619 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.2171 Highly Informative Inherited
Biological Process (BP) morphogenesis of a branching epithelium 0.1051 Highly Informative Inherited
Biological Process (BP) epithelial tube morphogenesis 0.135 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.05502 Least Informative Inherited
Molecular Function (MF) protein binding 3.44e-06 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.0761 Moderately Informative Inherited
Molecular Function (MF) heterocyclic compound binding 1 Moderately Informative Inherited
Molecular Function (MF) organic cyclic compound binding 1 Moderately Informative Inherited
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) nucleotide binding 0.005047 Informative Inherited
Molecular Function (MF) protein kinase activity 0 Highly Informative Direct
Molecular Function (MF) protein complex binding 0 Highly Informative Direct
Molecular Function (MF) ATP binding 1.641e-05 Highly Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) protein complex 0.268 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 0.0001003 Moderately Informative Direct
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) intrinsic to plasma membrane 1.57e-09 Informative Direct
Cellular Component (CC) integral to membrane 0.8179 Informative Inherited
Cellular Component (CC) endosome 0.01526 Informative Inherited
Cellular Component (CC) receptor complex 0 Highly Informative Direct
Cellular Component (CC) integral to plasma membrane 7.61e-07 Highly Informative Direct
Cellular Component (CC) late endosome 7.98e-06 Highly Informative Direct
Cellular Component (CC) membrane raft 0.03115 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.06133Least InformativeInherited
Disease Ontology (DO)immune system disease0.2312Least InformativeInherited
Disease Ontology (DO)nervous system disease0.9113Least InformativeInherited
Disease Ontology (DO)lung disease0.0007961Moderately InformativeDirect
Disease Ontology (DO)nervous system cancer0.008042Moderately InformativeInherited
Disease Ontology (DO)sensory system disease0.02042Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.982Moderately InformativeInherited
Disease Ontology (DO)retinal cancer9.227e-05InformativeDirect
Disease Ontology (DO)rheumatic disease0.0004417InformativeDirect
Disease Ontology (DO)connective tissue disease0.0005878InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.01336Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.12Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.2092Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digits0.0003801Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the vasculature0.06559Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genital system0.1649Moderately InformativeInherited
Phenotypic Abnormality (PA)Generalized abnormality of skin0.4772Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the uterus0.0004663InformativeDirect
Phenotypic Abnormality (PA)Vascular skin abnormality0.0004837InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the pulmonary artery0.0001912Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)embryogenesis phenotype0.01042Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.567Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryonic tissue morphology0.0001423InformativeDirect
Mammalian Phenotype (MP)abnormal vertebrae morphology0.0002994InformativeDirect
Mammalian Phenotype (MP)abnormal extraembryonic tissue morphology0.004223InformativeInherited
Mammalian Phenotype (MP)abnormal developmental patterning0.138InformativeInherited
Mammalian Phenotype (MP)absent allantois1.711e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal primitive streak morphology2.522e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal embryonic epiblast morphology0.0003648Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.3694Least InformativeInherited
Worm Phenotype (WP)lipid metabolism variant0.0004889InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)lethal0Least InformativeDirect
Fly Phenotype (FP)wild-type5.632e-05InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0.08502Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.1283Least InformativeInherited
Fly Anatomy (FA)cell0.2141Least InformativeInherited
Fly Anatomy (FA)larva0.4384Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)anatomical group0.005705Moderately InformativeInherited
Fly Anatomy (FA)appendage0.00755Moderately InformativeInherited
Fly Anatomy (FA)adult thorax0.009629Moderately InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument0.01222Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.01332Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment0.0142Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.01962Moderately InformativeInherited
Fly Anatomy (FA)portion of tissue0.02273Moderately InformativeInherited
Fly Anatomy (FA)developing material anatomical entity0.0613Moderately InformativeInherited
Fly Anatomy (FA)gonad0.1199Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.4777Moderately InformativeInherited
Fly Anatomy (FA)germline stem cell0.000101InformativeDirect
Fly Anatomy (FA)tracheal system0.00176InformativeInherited
Fly Anatomy (FA)male germline cell0.002035InformativeInherited
Fly Anatomy (FA)testis0.005215InformativeInherited
Fly Anatomy (FA)wing blade0.006157InformativeInherited
Fly Anatomy (FA)ovariole0.05775InformativeInherited
Fly Anatomy (FA)male germline stem cell2.871e-06Highly InformativeDirect
Fly Anatomy (FA)female germline stem cell2.45e-05Highly InformativeDirect
Fly Anatomy (FA)epithelial furrow0.000275Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)portion of tissue0Least InformativeDirect
Zebrafish Anatomy (ZA)multi-tissue structure0Least InformativeDirect
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)surface structure0Moderately InformativeDirect
Zebrafish Anatomy (ZA)trunk0Moderately InformativeDirect
Zebrafish Anatomy (ZA)cardiovascular system0InformativeDirect
Zebrafish Anatomy (ZA)median fin fold0InformativeDirect
Zebrafish Anatomy (ZA)coelom0InformativeDirect
Zebrafish Anatomy (ZA)heart0Highly InformativeDirect
Zebrafish Anatomy (ZA)heart rudiment0Highly InformativeDirect
Zebrafish Anatomy (ZA)ventral fin fold0Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)head0Least InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis5.523e-06Moderately InformativeDirect
Biological processCytolysis0InformativeDirect
Biological processGrowth regulation1.006e-12Highly InformativeDirect
Cellular componentMembrane1Least InformativeInherited
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCell membrane4.638e-06Moderately InformativeDirect
Cellular componentCell junction0.5465Moderately InformativeInherited
Cellular componentGPI-anchor0InformativeDirect
Cellular componentTight junction5.961e-07Highly InformativeDirect
DomainSignal0Least InformativeDirect
Molecular functionManganese2.034e-14Moderately InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationKinase5.78e-06Moderately InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationToxin0InformativeDirect
Post-translational modificationNeurotoxin0Highly InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect

Document: KW annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 42 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Snake toxin-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 42 hidden Markov models representing the Snake toxin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]