SUPERFAMILY 1.75 HMM library and genome assignments server


Snake toxin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Snake toxin-like [ 57301]
Superfamily:   Snake toxin-like [ 57302] (3)
Families:   Snake venom toxins [ 57303] (27)
  Dendroaspin [ 57351]
  Extracellular domain of cell surface receptors [ 57354] (6)


Superfamily statistics
Genomes (128) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 3,585 4,632 76
Proteins 3,288 4,186 68


Functional annotation
General category Processes_EC
Detailed category Toxins/defense

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process1.247e-070.000403Least InformativeDirect
Biological Process (BP)regulation of metabolic process10.03913Least InformativeInherited
Biological Process (BP)localization0.4010.004587Least InformativeInherited
Biological Process (BP)developmental process0.13740Least InformativeInherited
Biological Process (BP)multicellular organismal process0.060360Least InformativeInherited
Biological Process (BP)multi-organism process1.236e-060.0001675Moderately InformativeDirect
Biological Process (BP)negative regulation of metabolic process0.0048451Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.00012250.03971Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.0013860.2871Moderately InformativeInherited
Biological Process (BP)tissue development0.016961.5e-08Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.060072.574e-05Moderately InformativeInherited
Biological Process (BP)organic substance transport0.11030.4459Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.35190.07235Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.047887.333e-15Moderately InformativeInherited
Biological Process (BP)organ development0.043858.549e-07Moderately InformativeInherited
Biological Process (BP)tissue morphogenesis0.00014951.426e-10InformativeDirect
Biological Process (BP)cardiovascular system development0.00021870InformativeDirect
Biological Process (BP)gland development0.00025330.0001906InformativeDirect
Biological Process (BP)growth0.0036277.467e-08InformativeInherited
Biological Process (BP)regulation of immune effector process5.138e-090.2874InformativeInherited
Biological Process (BP)muscle tissue development0.0011190.8876InformativeInherited
Biological Process (BP)regulation of hormone levels0.0071020.07686InformativeInherited
Biological Process (BP)negative regulation of response to stimulus0.021570.09848InformativeInherited
Biological Process (BP)regulation of immune response0.25480.7517InformativeInherited
Biological Process (BP)regulation of defense response7.527e-070.01556InformativeInherited
Biological Process (BP)regulation of response to external stimulus0.032760.297InformativeInherited
Biological Process (BP)negative regulation of protein metabolic process0.0011970.8093InformativeInherited
Biological Process (BP)embryo development ending in birth or egg hatching4.892e-060.007984InformativeInherited
Biological Process (BP)regulation of humoral immune response2.618e-132.464e-05Highly InformativeDirect
Biological Process (BP)regulation of protein processing3.761e-134.604e-05Highly InformativeDirect
Biological Process (BP)pathogenesis2.713e-095.555e-05Highly InformativeDirect
Biological Process (BP)hormone transport1.634e-064.303e-06Highly InformativeDirect
Biological Process (BP)endocrine system development1.672e-067.732e-05Highly InformativeDirect
Biological Process (BP)negative regulation of immune system process3.597e-060.0002537Highly InformativeDirect
Biological Process (BP)organic hydroxy compound transport3.172e-051.831e-05Highly InformativeDirect
Biological Process (BP)regulation of inflammatory response5.345e-090.0558Highly InformativeInherited
Cellular Component (CC)membrane0.021010Least InformativeInherited
Cellular Component (CC)plasma membrane part3.54e-050Moderately InformativeDirect
Cellular Component (CC)cell surface7.95e-130InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 0.000403 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 5.923e-13 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) protein metabolic process 2.107e-09 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 7.001e-06 Least Informative Direct
Biological Process (BP) localization 0.004587 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.1858 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.03913 Least Informative Inherited
Biological Process (BP) multi-organism process 0.0001675 Moderately Informative Direct
Biological Process (BP) tissue development 1.5e-08 Moderately Informative Direct
Biological Process (BP) organ development 8.549e-07 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 7.333e-15 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 2.574e-05 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 4.102e-14 Moderately Informative Direct
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) cell differentiation 0 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 5.586e-15 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 7.333e-15 Moderately Informative Direct
Biological Process (BP) response to organic substance 9.408e-12 Moderately Informative Direct
Biological Process (BP) reproduction 3.384e-11 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 1.386e-08 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 6.731e-07 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.5143 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.07235 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.1461 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.04521 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.8778 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.1417 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.7193 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.8954 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.4459 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.02239 Moderately Informative Inherited
Biological Process (BP) system process 0.9894 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.01256 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.007911 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.773 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.06054 Moderately Informative Inherited
Biological Process (BP) immune system process 0.007834 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.2871 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.2132 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.03971 Moderately Informative Inherited
Biological Process (BP) tissue morphogenesis 1.426e-10 Informative Direct
Biological Process (BP) cardiovascular system development 0 Informative Direct
Biological Process (BP) gland development 0.0001906 Informative Direct
Biological Process (BP) growth 7.467e-08 Informative Direct
Biological Process (BP) organ morphogenesis 4.057e-11 Informative Direct
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0 Informative Direct
Biological Process (BP) positive regulation of developmental process 3.098e-13 Informative Direct
Biological Process (BP) regulation of growth 1.702e-12 Informative Direct
Biological Process (BP) locomotion 7.155e-11 Informative Direct
Biological Process (BP) regulation of protein phosphorylation 8.802e-10 Informative Direct
Biological Process (BP) embryonic morphogenesis 1.743e-09 Informative Direct
Biological Process (BP) single organism reproductive process 6.278e-09 Informative Direct
Biological Process (BP) cellular process involved in reproduction 1.331e-08 Informative Direct
Biological Process (BP) sensory organ development 2.012e-08 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 1.849e-07 Informative Direct
Biological Process (BP) localization of cell 3.126e-07 Informative Direct
Biological Process (BP) cellular component movement 6.487e-07 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 4.064e-06 Informative Direct
Biological Process (BP) lipid localization 1.049e-05 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 1.326e-05 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 2.09e-05 Informative Direct
Biological Process (BP) response to wounding 2.293e-05 Informative Direct
Biological Process (BP) negative regulation of developmental process 6.603e-05 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 6.692e-05 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 0.0001209 Informative Direct
Biological Process (BP) cell activation 0.000219 Informative Direct
Biological Process (BP) generation of neurons 0.0004847 Informative Direct
Biological Process (BP) positive regulation of protein metabolic process 0.000501 Informative Direct
Biological Process (BP) cell death 0.1388 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.2461 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.3405 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.003971 Informative Inherited
Biological Process (BP) epithelium development 0.7901 Informative Inherited
Biological Process (BP) regulation of secretion 0.02597 Informative Inherited
Biological Process (BP) defense response 0.07947 Informative Inherited
Biological Process (BP) response to bacterium 0.3288 Informative Inherited
Biological Process (BP) transmission of nerve impulse 0.3465 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.05922 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.6097 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.142 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.001708 Informative Inherited
Biological Process (BP) sexual reproduction 0.002394 Informative Inherited
Biological Process (BP) regulation of kinase activity 1 Informative Inherited
Biological Process (BP) response to organonitrogen compound 1 Informative Inherited
Biological Process (BP) response to hormone stimulus 1 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.2874 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.01148 Informative Inherited
Biological Process (BP) regulation of locomotion 0.03157 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) cell projection organization 0.2967 Informative Inherited
Biological Process (BP) muscle tissue development 0.8876 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.1509 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.07686 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.7849 Informative Inherited
Biological Process (BP) regulation of cell development 0.8546 Informative Inherited
Biological Process (BP) cell-cell signaling 0.8265 Informative Inherited
Biological Process (BP) protein complex assembly 0.1787 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 0.1902 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.09848 Informative Inherited
Biological Process (BP) regulation of immune response 0.7517 Informative Inherited
Biological Process (BP) regulation of defense response 0.01556 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.297 Informative Inherited
Biological Process (BP) positive regulation of cell proliferation 0.1448 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.8093 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.007984 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.02428 Informative Inherited
Biological Process (BP) regulation of humoral immune response 2.464e-05 Highly Informative Direct
Biological Process (BP) regulation of protein processing 4.604e-05 Highly Informative Direct
Biological Process (BP) pathogenesis 5.555e-05 Highly Informative Direct
Biological Process (BP) hormone transport 4.303e-06 Highly Informative Direct
Biological Process (BP) endocrine system development 7.732e-05 Highly Informative Direct
Biological Process (BP) negative regulation of immune system process 0.0002537 Highly Informative Direct
Biological Process (BP) organic hydroxy compound transport 1.831e-05 Highly Informative Direct
Biological Process (BP) protein phosphorylation 0 Highly Informative Direct
Biological Process (BP) pattern specification process 0 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 0 Highly Informative Direct
Biological Process (BP) stem cell development 0 Highly Informative Direct
Biological Process (BP) positive regulation of growth 1.431e-14 Highly Informative Direct
Biological Process (BP) mesenchyme development 1.036e-08 Highly Informative Direct
Biological Process (BP) lung development 7.204e-08 Highly Informative Direct
Biological Process (BP) cell division 1.831e-06 Highly Informative Direct
Biological Process (BP) cellular process involved in reproduction in multicellular organism 9.606e-06 Highly Informative Direct
Biological Process (BP) angiogenesis 1.271e-05 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 1.535e-05 Highly Informative Direct
Biological Process (BP) regulation of T cell activation 1.77e-05 Highly Informative Direct
Biological Process (BP) positive regulation of cell differentiation 2.036e-05 Highly Informative Direct
Biological Process (BP) regulation of multicellular organism growth 2.055e-05 Highly Informative Direct
Biological Process (BP) myeloid leukocyte activation 4.092e-05 Highly Informative Direct
Biological Process (BP) retina development in camera-type eye 4.257e-05 Highly Informative Direct
Biological Process (BP) regulation of peptide transport 5.437e-05 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 6.125e-05 Highly Informative Direct
Biological Process (BP) negative regulation of secretion 7.138e-05 Highly Informative Direct
Biological Process (BP) skeletal system development 9.109e-05 Highly Informative Direct
Biological Process (BP) neuron projection development 0.0006165 Highly Informative Direct
Biological Process (BP) post-embryonic organ development 0.0006831 Highly Informative Direct
Biological Process (BP) developmental growth 0.00597 Highly Informative Inherited
Biological Process (BP) cell growth 0.005997 Highly Informative Inherited
Biological Process (BP) renal system development 0.00646 Highly Informative Inherited
Biological Process (BP) connective tissue development 0.01516 Highly Informative Inherited
Biological Process (BP) defense response to bacterium 0.03488 Highly Informative Inherited
Biological Process (BP) cell part morphogenesis 0.9077 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.005601 Highly Informative Inherited
Biological Process (BP) cell fate commitment 0.02857 Highly Informative Inherited
Biological Process (BP) regulation of hormone secretion 0.008093 Highly Informative Inherited
Biological Process (BP) regulation of innate immune response 0.1657 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.001083 Highly Informative Inherited
Biological Process (BP) positive regulation of cell activation 0.01565 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.09846 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.001087 Highly Informative Inherited
Biological Process (BP) response to peptide hormone stimulus 0.009849 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 0.8801 Highly Informative Inherited
Biological Process (BP) regulation of inflammatory response 0.0558 Highly Informative Inherited
Biological Process (BP) regulation of cell adhesion 0.002104 Highly Informative Inherited
Biological Process (BP) response to carbohydrate stimulus 0.01042 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.4251 Highly Informative Inherited
Biological Process (BP) chemotaxis 0.4785 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 0.3622 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.3088 Highly Informative Inherited
Biological Process (BP) regulation of organ morphogenesis 0.009127 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.2151 Highly Informative Inherited
Biological Process (BP) morphogenesis of a branching epithelium 0.118 Highly Informative Inherited
Biological Process (BP) epithelial tube morphogenesis 0.1724 Highly Informative Inherited
Molecular Function (MF) binding 0.0006477 Least Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.03824 Moderately Informative Inherited
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 6.49e-05 Informative Direct
Molecular Function (MF) purine ribonucleoside binding 0.000102 Informative Direct
Molecular Function (MF) nucleotide binding 0.001637 Informative Inherited
Molecular Function (MF) protein kinase activity 0 Highly Informative Direct
Molecular Function (MF) protein complex binding 0 Highly Informative Direct
Molecular Function (MF) ATP binding 2.377e-06 Highly Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) protein complex 0.2036 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) plasma membrane part 0 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 2.176e-05 Moderately Informative Direct
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) intrinsic to plasma membrane 7.924e-09 Informative Direct
Cellular Component (CC) endosome 1.051e-05 Informative Direct
Cellular Component (CC) integral to membrane 0.7706 Informative Inherited
Cellular Component (CC) receptor complex 0 Highly Informative Direct
Cellular Component (CC) integral to plasma membrane 3.678e-06 Highly Informative Direct
Cellular Component (CC) early endosome 0.0003693 Highly Informative Direct
Cellular Component (CC) membrane raft 0.0406 Highly Informative Inherited
Cellular Component (CC) late endosome 0.02154 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.1429Least InformativeInherited
Disease Ontology (DO)lung disease0.00111Moderately InformativeInherited
Disease Ontology (DO)musculoskeletal system disease0.2612Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.9258Moderately InformativeInherited
Disease Ontology (DO)connective tissue disease0.0008099InformativeDirect
Disease Ontology (DO)rheumatic disease0.004194InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the abdomen0.3875Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.02771Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal genital system morphology0.06034Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.2028Moderately InformativeInherited
Phenotypic Abnormality (PA)Generalized abnormality of skin0.4557Moderately InformativeInherited
Phenotypic Abnormality (PA)Vascular skin abnormality0.0002028InformativeDirect
Phenotypic Abnormality (PA)Hernia0.01977InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal wall0.02314InformativeInherited
Phenotypic Abnormality (PA)Abnormality of female internal genitalia0.1426InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the pulmonary artery0.0001142Highly InformativeDirect
Phenotypic Abnormality (PA)Inguinal hernia0.0009525Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.008251Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.01756Least InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.001136Moderately InformativeInherited
Mammalian Phenotype (MP)muscle phenotype0.007247Moderately InformativeInherited
Mammalian Phenotype (MP)tumorigenesis0.009415Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.02905Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.05973Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.2173Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.3076Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.417Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.5972Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryogenesis/ development1Moderately InformativeInherited
Mammalian Phenotype (MP)increased malignant tumor incidence0.0005391InformativeDirect
Mammalian Phenotype (MP)abnormal preimplantation embryo development0.005435InformativeInherited
Mammalian Phenotype (MP)increased apoptosis0.09954InformativeInherited
Mammalian Phenotype (MP)abnormal developmental patterning0.1558InformativeInherited
Mammalian Phenotype (MP)abnormal sex determination0.4952InformativeInherited
Mammalian Phenotype (MP)abnormal embryonic epiblast morphology6.617e-07Highly InformativeDirect
Mammalian Phenotype (MP)abnormal primitive streak morphology2.297e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mesoderm development7.269e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal branchial arch artery morphology0.0003776Highly InformativeDirect
Mammalian Phenotype (MP)abnormal secondary sex determination0.0008169Highly InformativeDirect
Mammalian Phenotype (MP)abnormal embryonic-extraembryonic boundary morphology0.0009233Highly InformativeDirect
Mammalian Phenotype (MP)cardiomyopathy0.01287Highly InformativeInherited
Mammalian Phenotype (MP)dilated heart0.2497Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.3694Least InformativeInherited
Worm Phenotype (WP)lipid metabolism variant0.0004889InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect
Fly Phenotype (FP)lethal - all die before end of P-stage0Moderately InformativeDirect
Fly Phenotype (FP)wild-type7.783e-05InformativeDirect
Fly Phenotype (FP)size defective9.78e-05InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0.08611Least InformativeInherited
Fly Anatomy (FA)anatomical group0.09945Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.1308Least InformativeInherited
Fly Anatomy (FA)cell0.2233Least InformativeInherited
Fly Anatomy (FA)larva0.4609Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)appendage0.007706Moderately InformativeInherited
Fly Anatomy (FA)adult thorax0.009462Moderately InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument0.01248Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.01309Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment0.01457Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.02012Moderately InformativeInherited
Fly Anatomy (FA)portion of tissue0.02198Moderately InformativeInherited
Fly Anatomy (FA)developing material anatomical entity0.05595Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.05973Moderately InformativeInherited
Fly Anatomy (FA)reproductive system0.2091Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.5223Moderately InformativeInherited
Fly Anatomy (FA)germline stem cell0.0001026InformativeDirect
Fly Anatomy (FA)cell component0.0002588InformativeDirect
Fly Anatomy (FA)tracheal system0.001454InformativeInherited
Fly Anatomy (FA)male germline cell0.002328InformativeInherited
Fly Anatomy (FA)testis0.005545InformativeInherited
Fly Anatomy (FA)wing blade0.006033InformativeInherited
Fly Anatomy (FA)male germline stem cell2.573e-06Highly InformativeDirect
Fly Anatomy (FA)female germline stem cell2.644e-05Highly InformativeDirect
Fly Anatomy (FA)epithelial furrow0.000271Highly InformativeDirect
Fly Anatomy (FA)neuromuscular junction0.002523Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)trunk0Least InformativeDirect
Zebrafish Anatomy (ZA)portion of tissue0Least InformativeDirect
Zebrafish Anatomy (ZA)multi-tissue structure0Least InformativeDirect
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)anatomical space0Moderately InformativeDirect
Zebrafish Anatomy (ZA)heart rudiment6.955e-06InformativeDirect
Zebrafish Anatomy (ZA)ventral fin fold3.903e-05InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

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XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)anatomical direction0.0006976InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

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EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

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KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis1.167e-05Moderately InformativeDirect
Biological processCytolysis0InformativeDirect
Biological processGrowth regulation2.697e-12Highly InformativeDirect
Cellular componentMembrane1Least InformativeInherited
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCell membrane7.023e-07Moderately InformativeDirect
Cellular componentCell junction0.6584Moderately InformativeInherited
Cellular componentGPI-anchor0InformativeDirect
Cellular componentTight junction9.982e-07Highly InformativeDirect
DiseaseDisease mutation0.0003019Least InformativeDirect
DomainSignal0Least InformativeDirect
Molecular functionManganese4.81e-13Moderately InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationKinase1.953e-05Moderately InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationToxin0InformativeDirect
Post-translational modificationNeurotoxin0Highly InformativeDirect
Post-translational modificationIon channel impairing toxin4.212e-08Highly InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect

Document: KW annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 42 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Snake toxin-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 42 hidden Markov models representing the Snake toxin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]