SUPERFAMILY 1.75 HMM library and genome assignments server


Snake toxin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Snake toxin-like [ 57301]
Superfamily:   Snake toxin-like [ 57302] (3)
Families:   Snake venom toxins [ 57303] (27)
  Dendroaspin [ 57351]
  Extracellular domain of cell surface receptors [ 57354] (6)


Superfamily statistics
Genomes (140) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 3,973 5,624 76
Proteins 3,634 5,116 68


Functional annotation
General category Processes_EC
Detailed category Toxins/defense

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process2.123e-080.0003149Least InformativeDirect
Biological Process (BP)regulation of metabolic process10.05711Least InformativeInherited
Biological Process (BP)localization0.48270.01294Least InformativeInherited
Biological Process (BP)developmental process0.040060Least InformativeInherited
Biological Process (BP)multicellular organismal process0.017390Least InformativeInherited
Biological Process (BP)multi-organism process4.482e-060.0006074Moderately InformativeDirect
Biological Process (BP)negative regulation of metabolic process0.011090.8399Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.0002040.07496Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.0021840.01143Moderately InformativeInherited
Biological Process (BP)organ development0.15697.917e-07Moderately InformativeInherited
Biological Process (BP)tissue development0.0066762.006e-10Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.22990.0005443Moderately InformativeInherited
Biological Process (BP)organic substance transport0.12750.5093Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.33710.1549Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.85710.3993Moderately InformativeInherited
Biological Process (BP)negative regulation of immune system process1.135e-050.0006514InformativeDirect
Biological Process (BP)cardiovascular system development0.00021652.963e-14InformativeDirect
Biological Process (BP)tissue morphogenesis0.00047754.466e-09InformativeDirect
Biological Process (BP)gland development0.00048850.0004791InformativeDirect
Biological Process (BP)growth0.015141.08e-09InformativeInherited
Biological Process (BP)regulation of immune effector process9.752e-090.2931InformativeInherited
Biological Process (BP)muscle tissue development0.005240.9454InformativeInherited
Biological Process (BP)regulation of hormone levels0.0059240.07351InformativeInherited
Biological Process (BP)negative regulation of response to stimulus0.031930.1379InformativeInherited
Biological Process (BP)regulation of immune response0.23930.8261InformativeInherited
Biological Process (BP)regulation of defense response1.531e-060.1631InformativeInherited
Biological Process (BP)regulation of response to external stimulus0.033140.396InformativeInherited
Biological Process (BP)negative regulation of protein metabolic process0.001140.8115InformativeInherited
Biological Process (BP)embryo development ending in birth or egg hatching6.566e-060.00551InformativeInherited
Biological Process (BP)regulation of acute inflammatory response2.261e-131.292e-08Highly InformativeDirect
Biological Process (BP)regulation of humoral immune response3.322e-132.416e-05Highly InformativeDirect
Biological Process (BP)regulation of protein processing1.263e-125.953e-05Highly InformativeDirect
Biological Process (BP)pathogenesis3.782e-099.576e-05Highly InformativeDirect
Biological Process (BP)endocrine system development1.428e-060.0001139Highly InformativeDirect
Biological Process (BP)hormone transport1.846e-066.347e-06Highly InformativeDirect
Biological Process (BP)negative regulation of immune response2.3e-062.562e-08Highly InformativeDirect
Biological Process (BP)organic hydroxy compound transport3.791e-052.218e-05Highly InformativeDirect
Biological Process (BP)negative regulation of immune effector process3.19e-050.03384Highly InformativeInherited
Cellular Component (CC)membrane0.023180Least InformativeInherited
Cellular Component (CC)plasma membrane6.825e-050Moderately InformativeDirect
Cellular Component (CC)cell surface1.971e-120InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 0.0003149 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 9.892e-14 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) protein metabolic process 4.602e-09 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 1.449e-05 Least Informative Direct
Biological Process (BP) localization 0.01294 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.2676 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.05711 Least Informative Inherited
Biological Process (BP) multi-organism process 0.0006074 Moderately Informative Direct
Biological Process (BP) tissue development 2.006e-10 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0 Moderately Informative Direct
Biological Process (BP) reproduction 1.319e-11 Moderately Informative Direct
Biological Process (BP) organ development 7.917e-07 Moderately Informative Direct
Biological Process (BP) cell differentiation 0 Moderately Informative Direct
Biological Process (BP) response to organic substance 7.337e-13 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.0005443 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 1.435e-14 Moderately Informative Direct
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 9.148e-15 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 5.03e-09 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 6.264e-06 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 7.263e-05 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0.8399 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.4311 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.1549 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.2047 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.06392 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.039 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.7271 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.9333 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.5093 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.01895 Moderately Informative Inherited
Biological Process (BP) system process 0.9794 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.3993 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.01764 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.8277 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.05797 Moderately Informative Inherited
Biological Process (BP) immune system process 0.01754 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.01143 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.2956 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.07496 Moderately Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.0006514 Informative Direct
Biological Process (BP) cardiovascular system development 2.963e-14 Informative Direct
Biological Process (BP) tissue morphogenesis 4.466e-09 Informative Direct
Biological Process (BP) gland development 0.0004791 Informative Direct
Biological Process (BP) growth 1.08e-09 Informative Direct
Biological Process (BP) organ morphogenesis 4.866e-09 Informative Direct
Biological Process (BP) developmental process involved in reproduction 0.0001361 Informative Direct
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0 Informative Direct
Biological Process (BP) positive regulation of developmental process 9.575e-14 Informative Direct
Biological Process (BP) regulation of growth 5.907e-13 Informative Direct
Biological Process (BP) tube development 1.52e-10 Informative Direct
Biological Process (BP) locomotion 3.501e-10 Informative Direct
Biological Process (BP) cellular process involved in reproduction 1.185e-08 Informative Direct
Biological Process (BP) single organism reproductive process 1.481e-08 Informative Direct
Biological Process (BP) regulation of protein phosphorylation 1.698e-08 Informative Direct
Biological Process (BP) embryonic morphogenesis 2.972e-08 Informative Direct
Biological Process (BP) sensory organ development 2.939e-07 Informative Direct
Biological Process (BP) localization of cell 3.646e-07 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 6.057e-07 Informative Direct
Biological Process (BP) cellular component movement 4.536e-06 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 6.788e-06 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 6.795e-06 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 9.746e-06 Informative Direct
Biological Process (BP) lipid localization 1.482e-05 Informative Direct
Biological Process (BP) response to wounding 1.931e-05 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 4.164e-05 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 9.596e-05 Informative Direct
Biological Process (BP) generation of neurons 0.0003951 Informative Direct
Biological Process (BP) negative regulation of developmental process 0.0004696 Informative Direct
Biological Process (BP) apoptotic process 0.0008612 Informative Direct
Biological Process (BP) negative regulation of signaling 0.3162 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.4258 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.004328 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) regulation of secretion 0.02777 Informative Inherited
Biological Process (BP) negative regulation of transport 0.08282 Informative Inherited
Biological Process (BP) defense response 0.08119 Informative Inherited
Biological Process (BP) response to bacterium 0.3253 Informative Inherited
Biological Process (BP) synaptic transmission 0.006378 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.0484 Informative Inherited
Biological Process (BP) regulation of cell activation 0.07205 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.6083 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.3254 Informative Inherited
Biological Process (BP) leukocyte activation 0.1582 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.002549 Informative Inherited
Biological Process (BP) sexual reproduction 0.00304 Informative Inherited
Biological Process (BP) regulation of kinase activity 1 Informative Inherited
Biological Process (BP) response to organonitrogen compound 1 Informative Inherited
Biological Process (BP) response to hormone stimulus 1 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.2931 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.0129 Informative Inherited
Biological Process (BP) regulation of locomotion 0.03489 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) cell projection organization 0.2976 Informative Inherited
Biological Process (BP) muscle tissue development 0.9454 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.1114 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.02995 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.07351 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.7828 Informative Inherited
Biological Process (BP) regulation of cell development 0.8178 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 0.1736 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.1379 Informative Inherited
Biological Process (BP) regulation of immune response 0.8261 Informative Inherited
Biological Process (BP) regulation of defense response 0.1631 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.396 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.8115 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 0.001719 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.00551 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.03814 Informative Inherited
Biological Process (BP) regulation of acute inflammatory response 1.292e-08 Highly Informative Direct
Biological Process (BP) regulation of humoral immune response 2.416e-05 Highly Informative Direct
Biological Process (BP) regulation of protein processing 5.953e-05 Highly Informative Direct
Biological Process (BP) pathogenesis 9.576e-05 Highly Informative Direct
Biological Process (BP) endocrine system development 0.0001139 Highly Informative Direct
Biological Process (BP) hormone transport 6.347e-06 Highly Informative Direct
Biological Process (BP) negative regulation of immune response 2.562e-08 Highly Informative Direct
Biological Process (BP) organic hydroxy compound transport 2.218e-05 Highly Informative Direct
Biological Process (BP) protein phosphorylation 0 Highly Informative Direct
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0 Highly Informative Direct
Biological Process (BP) regulation of striated muscle tissue development 0 Highly Informative Direct
Biological Process (BP) pattern specification process 0 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 0 Highly Informative Direct
Biological Process (BP) positive regulation of growth 0 Highly Informative Direct
Biological Process (BP) regulation of striated muscle cell differentiation 0 Highly Informative Direct
Biological Process (BP) stem cell development 1.781e-11 Highly Informative Direct
Biological Process (BP) skeletal system development 2.395e-11 Highly Informative Direct
Biological Process (BP) respiratory system development 1.11e-10 Highly Informative Direct
Biological Process (BP) connective tissue development 5.358e-08 Highly Informative Direct
Biological Process (BP) mesenchyme development 5.383e-08 Highly Informative Direct
Biological Process (BP) respiratory tube development 2.605e-07 Highly Informative Direct
Biological Process (BP) cell division 3.417e-06 Highly Informative Direct
Biological Process (BP) cellular process involved in reproduction in multicellular organism 7.222e-06 Highly Informative Direct
Biological Process (BP) cell growth 8.647e-06 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 1.769e-05 Highly Informative Direct
Biological Process (BP) regulation of multicellular organism growth 1.818e-05 Highly Informative Direct
Biological Process (BP) regulation of T cell activation 2.366e-05 Highly Informative Direct
Biological Process (BP) angiogenesis 3.216e-05 Highly Informative Direct
Biological Process (BP) myeloid leukocyte activation 4.839e-05 Highly Informative Direct
Biological Process (BP) negative regulation of secretion 5.653e-05 Highly Informative Direct
Biological Process (BP) regulation of peptide transport 6.719e-05 Highly Informative Direct
Biological Process (BP) developmental growth 8.733e-05 Highly Informative Direct
Biological Process (BP) retina development in camera-type eye 0.0001031 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 0.0002195 Highly Informative Direct
Biological Process (BP) neuron projection development 0.0003169 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0.0004363 Highly Informative Direct
Biological Process (BP) cell-type specific apoptotic process 0.002697 Highly Informative Inherited
Biological Process (BP) renal system development 0.01197 Highly Informative Inherited
Biological Process (BP) defense response to bacterium 0.03634 Highly Informative Inherited
Biological Process (BP) cell part morphogenesis 0.859 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.02272 Highly Informative Inherited
Biological Process (BP) cell fate commitment 0.01641 Highly Informative Inherited
Biological Process (BP) regulation of hormone secretion 0.01134 Highly Informative Inherited
Biological Process (BP) regulation of innate immune response 0.1564 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.001613 Highly Informative Inherited
Biological Process (BP) positive regulation of cell activation 0.01437 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.1022 Highly Informative Inherited
Biological Process (BP) response to peptide hormone stimulus 0.008835 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 0.7453 Highly Informative Inherited
Biological Process (BP) regulation of cell adhesion 0.002721 Highly Informative Inherited
Biological Process (BP) response to carbohydrate stimulus 0.01858 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.003293 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.9477 Highly Informative Inherited
Biological Process (BP) chemotaxis 0.6121 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 0.3478 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.4161 Highly Informative Inherited
Biological Process (BP) regulation of organ morphogenesis 0.01167 Highly Informative Inherited
Biological Process (BP) negative regulation of immune effector process 0.03384 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.1968 Highly Informative Inherited
Biological Process (BP) branching morphogenesis of an epithelial tube 0.06015 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.002275 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.05805 Moderately Informative Inherited
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.0001216 Informative Direct
Molecular Function (MF) purine ribonucleoside binding 0.0001867 Informative Direct
Molecular Function (MF) nucleotide binding 0.002849 Informative Inherited
Molecular Function (MF) protein kinase activity 0 Highly Informative Direct
Molecular Function (MF) protein complex binding 0 Highly Informative Direct
Molecular Function (MF) ATP binding 4.91e-06 Highly Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) protein complex 0.2092 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 0.0003534 Moderately Informative Direct
Cellular Component (CC) cell projection 0.2262 Moderately Informative Inherited
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) intrinsic to plasma membrane 4.508e-09 Informative Direct
Cellular Component (CC) endosome 3.607e-06 Informative Direct
Cellular Component (CC) integral to membrane 0.7514 Informative Inherited
Cellular Component (CC) integral to plasma membrane 3.374e-06 Highly Informative Direct
Cellular Component (CC) receptor complex 0 Highly Informative Direct
Cellular Component (CC) late endosome 0.03866 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.1449Least InformativeInherited
Disease Ontology (DO)obstructive lung disease0.0001758Moderately InformativeDirect
Disease Ontology (DO)connective tissue disease0.0441Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.9224Moderately InformativeInherited
Disease Ontology (DO)rheumatic disease0.005129InformativeInherited
Disease Ontology (DO)collagen disease0.005723InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the abdomen0.3866Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.02571Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal genital system morphology0.06Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.2015Moderately InformativeInherited
Phenotypic Abnormality (PA)Generalized abnormality of skin0.4575Moderately InformativeInherited
Phenotypic Abnormality (PA)Vascular skin abnormality0.0001909InformativeDirect
Phenotypic Abnormality (PA)Hernia0.01922InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal wall0.02214InformativeInherited
Phenotypic Abnormality (PA)Abnormality of female internal genitalia0.02532InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the pulmonary artery0.0001018Highly InformativeDirect
Phenotypic Abnormality (PA)Inguinal hernia0.0009215Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.008352Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.01056Least InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.000437Moderately InformativeDirect
Mammalian Phenotype (MP)tumorigenesis0.01316Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.04675Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.1557Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.3487Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.3627Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.3798Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.6122Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryogenesis/ development1Moderately InformativeInherited
Mammalian Phenotype (MP)increased malignant tumor incidence0.0008415InformativeDirect
Mammalian Phenotype (MP)abnormal extraembryonic tissue morphology0.001622InformativeInherited
Mammalian Phenotype (MP)abnormal systemic artery morphology0.07964InformativeInherited
Mammalian Phenotype (MP)increased apoptosis0.08974InformativeInherited
Mammalian Phenotype (MP)abnormal developmental patterning0.09097InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial development0.1857InformativeInherited
Mammalian Phenotype (MP)abnormal angiogenesis0.2065InformativeInherited
Mammalian Phenotype (MP)abnormal sex determination0.3337InformativeInherited
Mammalian Phenotype (MP)abnormal embryonic epiblast morphology2.265e-08Highly InformativeDirect
Mammalian Phenotype (MP)abnormal primitive streak morphology1.628e-06Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mesoderm development7.021e-06Highly InformativeDirect
Mammalian Phenotype (MP)abnormal embryonic-extraembryonic boundary morphology7.871e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal aortic arch morphology0.0002715Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pharyngeal arch artery morphology0.000485Highly InformativeDirect
Mammalian Phenotype (MP)abnormal secondary sex determination0.0009187Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.3694Least InformativeInherited
Worm Phenotype (WP)lipid metabolism variant0.0004889InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect
Fly Phenotype (FP)lethal - all die before end of P-stage0Moderately InformativeDirect
Fly Phenotype (FP)wild-type5.464e-05InformativeDirect
Fly Phenotype (FP)size defective0.0003901InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0.07846Least InformativeInherited
Fly Anatomy (FA)anatomical group0.0899Least InformativeInherited
Fly Anatomy (FA)adult0.09409Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.1215Least InformativeInherited
Fly Anatomy (FA)cell0.2144Least InformativeInherited
Fly Anatomy (FA)larva0.4491Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)appendage0.006605Moderately InformativeInherited
Fly Anatomy (FA)adult thorax0.008226Moderately InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument0.01027Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.01086Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment0.01261Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.01781Moderately InformativeInherited
Fly Anatomy (FA)developing material anatomical entity0.05168Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.05919Moderately InformativeInherited
Fly Anatomy (FA)reproductive system0.1874Moderately InformativeInherited
Fly Anatomy (FA)epithelium0.497Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.5201Moderately InformativeInherited
Fly Anatomy (FA)germline stem cell9.312e-05InformativeDirect
Fly Anatomy (FA)cell component0.0004569InformativeDirect
Fly Anatomy (FA)tracheal system0.001365InformativeInherited
Fly Anatomy (FA)male germline cell0.002105InformativeInherited
Fly Anatomy (FA)wing blade0.004949InformativeInherited
Fly Anatomy (FA)male reproductive system0.005713InformativeInherited
Fly Anatomy (FA)ovariole0.05191InformativeInherited
Fly Anatomy (FA)male germline stem cell2.364e-06Highly InformativeDirect
Fly Anatomy (FA)female germline stem cell2.427e-05Highly InformativeDirect
Fly Anatomy (FA)epithelial furrow0.0002835Highly InformativeDirect
Fly Anatomy (FA)neuromuscular junction0.003007Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)trunk0Least InformativeDirect
Zebrafish Anatomy (ZA)portion of tissue0Least InformativeDirect
Zebrafish Anatomy (ZA)multi-tissue structure0Least InformativeDirect
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)anatomical space0Moderately InformativeDirect
Zebrafish Anatomy (ZA)heart rudiment6.463e-06InformativeDirect
Zebrafish Anatomy (ZA)ventral fin fold3.737e-05InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)anatomical direction0.0009105InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis1.224e-05Moderately InformativeDirect
Biological processCytolysis0InformativeDirect
Biological processGrowth regulation8.132e-12Highly InformativeDirect
Cellular componentMembrane1Least InformativeInherited
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCell membrane7.048e-07Moderately InformativeDirect
Cellular componentCell junction0.6773Moderately InformativeInherited
Cellular componentGPI-anchor0InformativeDirect
Cellular componentTight junction9.954e-07Highly InformativeDirect
DiseaseDisease mutation0.000398Least InformativeDirect
DomainSignal0Least InformativeDirect
Molecular functionManganese7.775e-13Moderately InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationKinase2.207e-05Moderately InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationToxin0InformativeDirect
Post-translational modificationNeurotoxin0Highly InformativeDirect
Post-translational modificationIon channel impairing toxin6.085e-08Highly InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect

Document: KW annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 42 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Snake toxin-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 42 hidden Markov models representing the Snake toxin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]