SUPERFAMILY 1.75 HMM library and genome assignments server


Granulin repeat superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Knottins (small inhibitors, toxins, lectins) [ 57015] (19)
Superfamily:   Granulin repeat [ 57277]
Families:   Granulin repeat [ 57278] (2)


Superfamily statistics
Genomes (159) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,244 1,407 4
Proteins 538 532 4


Functional annotation
General category General
Detailed category General

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) developmental process 2.226e-09 Least Informative Direct
Biological Process (BP) multicellular organismal process 1.613e-08 Least Informative Direct
Biological Process (BP) regulation of cellular process 2.818e-07 Least Informative Direct
Biological Process (BP) reproduction 0 Moderately Informative Direct
Biological Process (BP) multi-organism process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 2.276e-07 Moderately Informative Direct
Biological Process (BP) embryo development ending in birth or egg hatching 0 Informative Direct
Biological Process (BP) multi-multicellular organism process 0 Informative Direct
Biological Process (BP) single organism reproductive process 1.944e-15 Informative Direct
Biological Process (BP) positive regulation of cell proliferation 4.131e-14 Informative Direct
Biological Process (BP) positive regulation of epithelial cell proliferation 0 Highly Informative Direct
Biological Process (BP) female pregnancy 3.087e-07 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 5.431e-09 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.0001497 Least Informative Direct
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) extracellular space 1.708e-05 Informative Direct

Document: GO annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0Least InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentSecreted8.498e-11Moderately InformativeDirect
DomainSignal7.779e-09Least InformativeDirect
Post-translational modificationHydrolase0.02854Least InformativeInherited
Post-translational modificationProtease8.283e-07Moderately InformativeDirect
Post-translational modificationThiol protease2.912e-11InformativeDirect
Post-translational modificationCytokine0Highly InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationZymogen2.065e-05InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Granulin repeat domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the Granulin repeat superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]