SUPERFAMILY 1.75 HMM library and genome assignments server

Leech antihemostatic proteins superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Knottins (small inhibitors, toxins, lectins) [ 57015] (19)
Superfamily:   Leech antihemostatic proteins [ 57262] (2)
Families:   Huristasin-like [ 57263] (3)
  Hirudin-like [ 57270] (3)

Superfamily statistics
Genomes (126) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 708 662 12
Proteins 272 290 11

Functional annotation
General category Processes_IC
Detailed category Proteases

Function annotation of SCOP domain superfamilies

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentSecreted0Moderately InformativeDirect
DomainSignal0.00000009548Least InformativeDirect
Post-translational modificationProtease inhibitor0InformativeDirect
Post-translational modificationDisulfide bond0.00000001117Least InformativeDirect
Post-translational modificationGlycoprotein0.00000633Least InformativeDirect
Post-translational modificationSulfation0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR011061 SSF57262 Protein matches

Leeches, such as the medicinal leech Hirudo medicinalis, produce a variety of antihaemostatic proteins that act as proteinase inhibitors. These inhibitors are used to aid the leech in feeding upon its host by blocking blood coagulation [PubMed11563948, PubMed11257492]. Examples of these proteins include hirustasin (inhibitor of tissue kallikrein, trypsin, alpha-chymotrypsin, and granulocyte cathepsin G) [PubMed10368273], bdellastasin (inhibitor of trypsin, plasmin, and acrosin) [PubMed10512718], factor Xa inhibitor antistasin (inhibitor of blood coagulation factor Xa) [PubMed9311976], hirudin (thrombin inhibitor), decorsin (inhibitor of platelet aggregation) [PubMed8607116] and haemadin (thrombin inhibitor) [PubMed11851400].

InterPro database

PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a Leech antihemostatic proteins domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the Leech antihemostatic proteins superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · UniProtKB KeyWords (KW) · Internal database links ]