SUPERFAMILY 1.75 HMM library and genome assignments server

Elafin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Knottins (small inhibitors, toxins, lectins) [ 57015] (19)
Superfamily:   Elafin-like [ 57256]
Families:   Elafin-like [ 57257] (2)


Superfamily statistics
Genomes (133) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 2,433 2,087 2
Proteins 1,318 1,432 2


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of metabolic process0.020420.1747Least InformativeInherited
Biological Process (BP)response to stimulus0.33820.2041Least InformativeInherited
Biological Process (BP)regulation of catalytic activity0.0006590.0009096Moderately InformativeDirect
Biological Process (BP)response to external stimulus0.0025340.0007027Moderately InformativeInherited
Biological Process (BP)multi-organism process0.010920.001216Moderately InformativeInherited
Biological Process (BP)response to bacterium0.000033920.000000249InformativeDirect
Molecular Function (MF)enzyme regulator activity0.00026440.000001608Moderately InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of metabolic process 0.1747 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.3305 Least Informative Inherited
Biological Process (BP) response to stimulus 0.2041 Least Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.0009096 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0.0007027 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.000147 Moderately Informative Direct
Biological Process (BP) defense response 0.0003773 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0.004159 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.001717 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.0211 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.001216 Moderately Informative Inherited
Biological Process (BP) response to bacterium 0.000000249 Informative Direct
Biological Process (BP) negative regulation of protein processing 0.0000000000009109 Informative Direct
Biological Process (BP) regulation of peptidase activity 0.000000000004133 Informative Direct
Biological Process (BP) negative regulation of cellular protein metabolic process 0.000000008725 Informative Direct
Biological Process (BP) negative regulation of catalytic activity 0.00001221 Informative Direct
Biological Process (BP) defense response to other organism 0.0006642 Informative Direct
Biological Process (BP) regulation of binding 0.002946 Highly Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.000001608 Moderately Informative Direct
Molecular Function (MF) peptidase regulator activity 0.0000148 Informative Direct
Molecular Function (MF) enzyme inhibitor activity 0.0002317 Informative Direct
Cellular Component (CC) extracellular region part 0.000001863 Moderately Informative Direct
Cellular Component (CC) extracellular matrix 0.00001128 Informative Direct

Document: GO annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect

Document: WP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentSecreted0Moderately InformativeDirect
DomainSignal0Least InformativeDirect
Post-translational modificationProtease inhibitor0InformativeDirect
Post-translational modificationToxin0InformativeDirect
Post-translational modificationAntimicrobial0InformativeDirect
Post-translational modificationMetalloenzyme inhibitor0.000000000000002638Highly InformativeDirect
Post-translational modificationAntibiotic0.00000000005736Highly InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008197 SSF57256 Protein matches
Abstract

Whey acidic protein (WAP) is a major component of the whey fraction of milk, which contains a significant number of different proteins. WAP proteins share limited sequence identity, except for their conserved cysteine-rich regions, known as 4-disulphide core (4-DSC) domains, and the positional conservation of specific residues [PubMed12751894]. Several non-milk proteins also contain 4-DSC patterns, such as certain serine protease inhibitors. WAP itself appears to have a protease-inhibitor function, as seen with its inhibitory effect on the progression of cancer cells [PubMed17215074].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Worm Phenotype (WP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Elafin-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Elafin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Worm Phenotype (WP) · UniProtKB KeyWords (KW) · Internal database links ]