SUPERFAMILY 1.75 HMM library and genome assignments server


EGF/Laminin superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Knottins (small inhibitors, toxins, lectins) [ 57015] (19)
Superfamily:   EGF/Laminin [ 57196] (7)
Families:   EGF-type module [ 57197] (22)
  Integrin beta EGF-like domains [ 69940]
  EGF-like domain of nidogen-1 [ 64541]
  Laminin-type module [ 57233]
  Follistatin (FS) module N-terminal domain, FS-N [ 57236] (2)
  Merozoite surface protein 1 (MSP-1) [ 57239]
  Cripto EGF-like domain-like [ 144100]


Superfamily statistics
Genomes (235) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 68,509 64,657 117
Proteins 21,215 21,997 88


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)developmental process00Least InformativeDirect
Biological Process (BP)multicellular organismal process00Least InformativeDirect
Biological Process (BP)single-organism developmental process00Moderately InformativeDirect
Cellular Component (CC)membrane00Least InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism developmental process 0 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0 Moderately Informative Direct
Biological Process (BP) nervous system development 1.547e-11 Moderately Informative Direct
Biological Process (BP) signal transduction 1.181e-09 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 7.607e-09 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 1.068e-07 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 1.296e-07 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 4.387e-07 Moderately Informative Direct
Biological Process (BP) immune system process 1.048e-05 Moderately Informative Direct
Biological Process (BP) reproduction 2.143e-05 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 6.24e-05 Moderately Informative Direct
Biological Process (BP) regulation of localization 9.038e-05 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.0002725 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0.0002784 Moderately Informative Direct
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.5903 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.2928 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 0.3824 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.02614 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of programmed cell death 0.1692 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organ development 0.004438 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.1506 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.5457 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.4452 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.2597 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecule catabolic process 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.03782 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.4936 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 0.7279 Moderately Informative Inherited
Biological Process (BP) single-organism biosynthetic process 0.9759 Moderately Informative Inherited
Biological Process (BP) cellular component movement 0 Informative Direct
Biological Process (BP) regulation of cellular component movement 0 Informative Direct
Biological Process (BP) biological adhesion 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) cell projection organization 0 Informative Direct
Biological Process (BP) regulation of locomotion 0 Informative Direct
Biological Process (BP) localization of cell 0 Informative Direct
Biological Process (BP) negative regulation of developmental process 0 Informative Direct
Biological Process (BP) response to wounding 0 Informative Direct
Biological Process (BP) growth 7.333e-15 Informative Direct
Biological Process (BP) cardiovascular system development 2.112e-14 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 4.88e-12 Informative Direct
Biological Process (BP) cellular component morphogenesis 1.006e-11 Informative Direct
Biological Process (BP) positive regulation of protein metabolic process 1.11e-10 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 4.988e-10 Informative Direct
Biological Process (BP) vesicle-mediated transport 1.613e-08 Informative Direct
Biological Process (BP) generation of neurons 5.708e-08 Informative Direct
Biological Process (BP) positive regulation of cell proliferation 5.758e-08 Informative Direct
Biological Process (BP) organ morphogenesis 2.284e-07 Informative Direct
Biological Process (BP) regulation of anatomical structure size 2.549e-07 Informative Direct
Biological Process (BP) tissue morphogenesis 9.21e-07 Informative Direct
Biological Process (BP) regulation of body fluid levels 1.103e-06 Informative Direct
Biological Process (BP) regulation of protein phosphorylation 5.084e-06 Informative Direct
Biological Process (BP) positive regulation of developmental process 5.231e-06 Informative Direct
Biological Process (BP) regulation of growth 6.664e-06 Informative Direct
Biological Process (BP) negative regulation of cell communication 2.364e-05 Informative Direct
Biological Process (BP) negative regulation of signaling 2.53e-05 Informative Direct
Biological Process (BP) regulation of peptidase activity 3.103e-05 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 7.48e-05 Informative Direct
Biological Process (BP) embryo development ending in birth or egg hatching 8.8e-05 Informative Direct
Biological Process (BP) gland development 0.0001086 Informative Direct
Biological Process (BP) embryonic morphogenesis 0.0001832 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0.0002031 Informative Direct
Biological Process (BP) monocarboxylic acid biosynthetic process 0.0002223 Informative Direct
Biological Process (BP) regulation of nervous system development 0.0003118 Informative Direct
Biological Process (BP) embryonic organ development 0.0003195 Informative Direct
Biological Process (BP) steroid metabolic process 0.0005965 Informative Direct
Biological Process (BP) defense response 0.0007628 Informative Direct
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.4406 Informative Inherited
Biological Process (BP) membrane organization 0.1648 Informative Inherited
Biological Process (BP) protein transport 0.001355 Informative Inherited
Biological Process (BP) regulation of cytokine production 1 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 1 Informative Inherited
Biological Process (BP) muscle tissue development 0.4818 Informative Inherited
Biological Process (BP) muscle structure development 0.006522 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.5109 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) sensory organ development 0.03098 Informative Inherited
Biological Process (BP) epithelium development 0.1458 Informative Inherited
Biological Process (BP) cell-cell signaling 0.0128 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.1469 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.3256 Informative Inherited
Biological Process (BP) protein complex assembly 0.1196 Informative Inherited
Biological Process (BP) regulation of secretion 0.1785 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.8344 Informative Inherited
Biological Process (BP) single-organism behavior 0.01717 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.125 Informative Inherited
Biological Process (BP) positive regulation of transport 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.07178 Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.008346 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.005044 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.9274 Informative Inherited
Biological Process (BP) regulation of cell cycle 1 Informative Inherited
Biological Process (BP) regulation of cell development 0.2392 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.02153 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.4452 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 1 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.8465 Informative Inherited
Biological Process (BP) cell death 1 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.5872 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.01182 Informative Inherited
Biological Process (BP) response to cytokine stimulus 0.5598 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.02569 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.03897 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.471 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 0.557 Informative Inherited
Biological Process (BP) transmission of nerve impulse 0.5811 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.0192 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.08887 Informative Inherited
Biological Process (BP) central nervous system development 0.05519 Informative Inherited
Biological Process (BP) phosphorylation 1 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.1404 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.1332 Informative Inherited
Biological Process (BP) lipid localization 0.9844 Informative Inherited
Biological Process (BP) regulation of hormone levels 1 Informative Inherited
Biological Process (BP) response to light stimulus 0.9402 Informative Inherited
Biological Process (BP) response to nutrient levels 0.1673 Informative Inherited
Biological Process (BP) single organism reproductive process 0.08123 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.2443 Informative Inherited
Biological Process (BP) sexual reproduction 0.2467 Informative Inherited
Biological Process (BP) cytoplasmic transport 1 Informative Inherited
Biological Process (BP) protein localization to organelle 1 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 1 Informative Inherited
Biological Process (BP) blood circulation 1 Informative Inherited
Biological Process (BP) secretion by cell 0.2027 Informative Inherited
Biological Process (BP) immune response 0.7781 Informative Inherited
Biological Process (BP) immune effector process 0.9493 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) chemotaxis 0 Highly Informative Direct
Biological Process (BP) cell adhesion 0 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 1.945e-13 Highly Informative Direct
Biological Process (BP) cell junction organization 6.065e-12 Highly Informative Direct
Biological Process (BP) fatty acid derivative metabolic process 1.068e-11 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 6.328e-11 Highly Informative Direct
Biological Process (BP) positive regulation of protein kinase activity 9.574e-11 Highly Informative Direct
Biological Process (BP) regulation of cell growth 1.394e-10 Highly Informative Direct
Biological Process (BP) unsaturated fatty acid metabolic process 3.895e-10 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 2.618e-09 Highly Informative Direct
Biological Process (BP) regulation of wound healing 2.629e-09 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 8.05e-09 Highly Informative Direct
Biological Process (BP) pattern specification process 8.06e-09 Highly Informative Direct
Biological Process (BP) positive regulation of cell differentiation 8.932e-09 Highly Informative Direct
Biological Process (BP) skeletal system development 1.537e-08 Highly Informative Direct
Biological Process (BP) regulation of mitosis 3.701e-08 Highly Informative Direct
Biological Process (BP) telencephalon development 1.008e-07 Highly Informative Direct
Biological Process (BP) regulation of blood pressure 1.188e-07 Highly Informative Direct
Biological Process (BP) positive regulation of peptidyl-tyrosine phosphorylation 1.314e-07 Highly Informative Direct
Biological Process (BP) cell part morphogenesis 3.211e-07 Highly Informative Direct
Biological Process (BP) positive regulation of protein kinase B signaling cascade 4.101e-07 Highly Informative Direct
Biological Process (BP) regulation of cell size 4.761e-07 Highly Informative Direct
Biological Process (BP) neuron projection development 6.488e-07 Highly Informative Direct
Biological Process (BP) protein activation cascade 7.754e-07 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 1.176e-06 Highly Informative Direct
Biological Process (BP) regulation of behavior 2.47e-06 Highly Informative Direct
Biological Process (BP) female gamete generation 2.576e-06 Highly Informative Direct
Biological Process (BP) mammary gland epithelium development 4.406e-06 Highly Informative Direct
Biological Process (BP) coagulation 4.93e-06 Highly Informative Direct
Biological Process (BP) sterol metabolic process 1.331e-05 Highly Informative Direct
Biological Process (BP) humoral immune response 2.17e-05 Highly Informative Direct
Biological Process (BP) positive regulation of response to external stimulus 2.689e-05 Highly Informative Direct
Biological Process (BP) hormone transport 3.087e-05 Highly Informative Direct
Biological Process (BP) positive regulation of intracellular transport 3.961e-05 Highly Informative Direct
Biological Process (BP) regulation of coagulation 4.44e-05 Highly Informative Direct
Biological Process (BP) female pregnancy 4.655e-05 Highly Informative Direct
Biological Process (BP) developmental growth 5.399e-05 Highly Informative Direct
Biological Process (BP) plasma membrane organization 5.428e-05 Highly Informative Direct
Biological Process (BP) phagocytosis 0.0001082 Highly Informative Direct
Biological Process (BP) detection of light stimulus 0.0001306 Highly Informative Direct
Biological Process (BP) positive regulation of protein transport 0.0001667 Highly Informative Direct
Biological Process (BP) glial cell differentiation 0.0002119 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0.0002346 Highly Informative Direct
Biological Process (BP) muscle organ development 0.0002433 Highly Informative Direct
Biological Process (BP) regulation of hemostasis 0.0002762 Highly Informative Direct
Biological Process (BP) regulation of intracellular protein transport 0.0003699 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0.0004298 Highly Informative Direct
Biological Process (BP) aminoglycan catabolic process 0.0004691 Highly Informative Direct
Biological Process (BP) regulation of nitric oxide biosynthetic process 0.0007315 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 0.0008257 Highly Informative Direct
Biological Process (BP) embryonic organ morphogenesis 0.0009424 Highly Informative Direct
Biological Process (BP) leukocyte migration 0.0009602 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.08922 Highly Informative Inherited
Biological Process (BP) regulation of organ morphogenesis 0.8514 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.002064 Highly Informative Inherited
Biological Process (BP) extracellular matrix organization 1 Highly Informative Inherited
Biological Process (BP) response to drug 0.1307 Highly Informative Inherited
Biological Process (BP) cell fate commitment 0.3556 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.9106 Highly Informative Inherited
Biological Process (BP) muscle fiber development 0.001038 Highly Informative Inherited
Biological Process (BP) response to carbohydrate stimulus 0.1453 Highly Informative Inherited
Biological Process (BP) carbohydrate homeostasis 0.03183 Highly Informative Inherited
Biological Process (BP) mesenchyme development 0.1298 Highly Informative Inherited
Biological Process (BP) cardiocyte differentiation 0.06728 Highly Informative Inherited
Biological Process (BP) retina development in camera-type eye 0.004828 Highly Informative Inherited
Biological Process (BP) connective tissue development 0.01986 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.05128 Highly Informative Inherited
Biological Process (BP) protein tetramerization 0.3838 Highly Informative Inherited
Biological Process (BP) sensory perception 1 Highly Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 0.2044 Highly Informative Inherited
Biological Process (BP) negative regulation of secretion 0.001656 Highly Informative Inherited
Biological Process (BP) regulation of protein secretion 0.06342 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.001834 Highly Informative Inherited
Biological Process (BP) post-embryonic development 1 Highly Informative Inherited
Biological Process (BP) negative regulation of growth 0.008149 Highly Informative Inherited
Biological Process (BP) signal release 0.4558 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 0.005535 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cell activation 0.6892 Highly Informative Inherited
Biological Process (BP) interaction with host 0.1139 Highly Informative Inherited
Biological Process (BP) regulation of MAP kinase activity 0.008002 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 0.9938 Highly Informative Inherited
Biological Process (BP) negative regulation of endopeptidase activity 0.05398 Highly Informative Inherited
Biological Process (BP) regulation of cysteine-type endopeptidase activity 0.9904 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.3597 Highly Informative Inherited
Biological Process (BP) photoreceptor cell differentiation 1 Highly Informative Inherited
Biological Process (BP) regulation of protein catabolic process 0.01126 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 1 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.8401 Highly Informative Inherited
Biological Process (BP) response to purine-containing compound 0.005724 Highly Informative Inherited
Biological Process (BP) negative regulation of protein transport 0.2721 Highly Informative Inherited
Biological Process (BP) regulation of nucleocytoplasmic transport 0.06008 Highly Informative Inherited
Biological Process (BP) regulation of protein localization to nucleus 0.01166 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular transport 0.01507 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 1 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 1 Highly Informative Inherited
Biological Process (BP) limb morphogenesis 0.0169 Highly Informative Inherited
Biological Process (BP) glycosaminoglycan metabolic process 0.02582 Highly Informative Inherited
Biological Process (BP) multi-organism cellular process 0.7324 Highly Informative Inherited
Biological Process (BP) peptidyl-serine modification 0.001795 Highly Informative Inherited
Biological Process (BP) protein phosphorylation 1 Highly Informative Inherited
Biological Process (BP) regulation of angiogenesis 0.01274 Highly Informative Inherited
Biological Process (BP) organic hydroxy compound transport 0.004106 Highly Informative Inherited
Biological Process (BP) inner ear development 0.1748 Highly Informative Inherited
Biological Process (BP) epidermal cell differentiation 0.05916 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 1 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.6107 Highly Informative Inherited
Biological Process (BP) protein import 0.04054 Highly Informative Inherited
Biological Process (BP) nuclear import 0.05851 Highly Informative Inherited
Biological Process (BP) protein localization to nucleus 0.1303 Highly Informative Inherited
Biological Process (BP) protein targeting to nucleus 0.4187 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 0.001493 Highly Informative Inherited
Biological Process (BP) cardiac muscle tissue development 0.97 Highly Informative Inherited
Biological Process (BP) exocytosis 0.9312 Highly Informative Inherited
Biological Process (BP) activation of immune response 0.4442 Highly Informative Inherited
Biological Process (BP) innate immune response 0.107 Highly Informative Inherited
Biological Process (BP) neural tube development 0.5121 Highly Informative Inherited
Biological Process (BP) tube formation 0.615 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 1 Highly Informative Inherited
Biological Process (BP) epithelial tube morphogenesis 0.01215 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) structural molecule activity 8.923e-15 Moderately Informative Direct
Molecular Function (MF) anion binding 0.4791 Moderately Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.3152 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) cation binding 0.4874 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0 Informative Direct
Molecular Function (MF) receptor binding 0 Informative Direct
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) sulfur compound binding 2.16e-13 Informative Direct
Molecular Function (MF) carboxylic acid binding 4.696e-05 Informative Direct
Molecular Function (MF) tetrapyrrole binding 9.076e-05 Informative Direct
Molecular Function (MF) peptidase regulator activity 0.0005057 Informative Direct
Molecular Function (MF) lipid binding 0.0007424 Informative Direct
Molecular Function (MF) enzyme inhibitor activity 0.0008279 Informative Direct
Molecular Function (MF) molecular transducer activity 0.01464 Informative Inherited
Molecular Function (MF) enzyme activator activity 0.003428 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 0.6861 Informative Inherited
Molecular Function (MF) inorganic cation transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1 Informative Inherited
Molecular Function (MF) peptidase activity 0.00327 Informative Inherited
Molecular Function (MF) enzyme binding 1 Informative Inherited
Molecular Function (MF) calcium ion binding 0 Highly Informative Direct
Molecular Function (MF) glycolipid binding 6.004e-15 Highly Informative Direct
Molecular Function (MF) heparin binding 9.163e-14 Highly Informative Direct
Molecular Function (MF) protein complex binding 1.985e-12 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 4.337e-06 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase inhibitor activity 9.863e-06 Highly Informative Direct
Molecular Function (MF) endopeptidase activity 2.464e-05 Highly Informative Direct
Molecular Function (MF) heme binding 5.938e-05 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0.0001021 Highly Informative Direct
Molecular Function (MF) peroxidase activity 0.0005369 Highly Informative Direct
Molecular Function (MF) amino acid binding 0.333 Highly Informative Inherited
Molecular Function (MF) protein kinase regulator activity 0.2384 Highly Informative Inherited
Molecular Function (MF) ion gated channel activity 0.4661 Highly Informative Inherited
Molecular Function (MF) ion channel activity 0.7554 Highly Informative Inherited
Molecular Function (MF) growth factor receptor binding 0.00189 Highly Informative Inherited
Molecular Function (MF) protein kinase activity 1 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.3498 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) plasma membrane part 0 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) cell projection 1.002e-12 Moderately Informative Direct
Cellular Component (CC) vesicle 1.709e-10 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 0.1847 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.002487 Moderately Informative Inherited
Cellular Component (CC) extracellular matrix 0 Informative Direct
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 4.413e-11 Informative Direct
Cellular Component (CC) cell leading edge 1.169e-07 Informative Direct
Cellular Component (CC) Golgi apparatus 1.859e-06 Informative Direct
Cellular Component (CC) endosome 0.0001554 Informative Direct
Cellular Component (CC) vacuolar part 0.003265 Informative Inherited
Cellular Component (CC) lytic vacuole 0.001459 Informative Inherited
Cellular Component (CC) secretory granule 0.05547 Informative Inherited
Cellular Component (CC) intrinsic to plasma membrane 0.06414 Informative Inherited
Cellular Component (CC) integral to membrane 0.1674 Informative Inherited
Cellular Component (CC) proteinaceous extracellular matrix 0 Highly Informative Direct
Cellular Component (CC) extracellular matrix part 0 Highly Informative Direct
Cellular Component (CC) receptor complex 2.972e-15 Highly Informative Direct
Cellular Component (CC) cell-substrate junction 1.546e-06 Highly Informative Direct
Cellular Component (CC) external side of plasma membrane 1.608e-06 Highly Informative Direct
Cellular Component (CC) vacuolar lumen 1.843e-06 Highly Informative Direct
Cellular Component (CC) sarcoplasmic reticulum 3.951e-06 Highly Informative Direct
Cellular Component (CC) adherens junction 3.959e-06 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 1.019e-05 Highly Informative Direct
Cellular Component (CC) lipid particle 0.0001484 Highly Informative Direct
Cellular Component (CC) integral to plasma membrane 0.0001788 Highly Informative Direct
Cellular Component (CC) neuromuscular junction 0.0001801 Highly Informative Direct
Cellular Component (CC) lysosome 0.0001836 Highly Informative Direct
Cellular Component (CC) ion channel complex 0.9991 Highly Informative Inherited
Cellular Component (CC) membrane raft 0.2499 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

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EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases0.0002233Least InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Miscellaneous (requires further characterization)0InformativeDirect
Enzyme Commission (EC)Peroxidases6.591e-06InformativeDirect
Enzyme Commission (EC)Coagulation factor IXa2.266e-11Highly InformativeDirect
Enzyme Commission (EC)Complement subcomponent C1s2.421e-10Highly InformativeDirect
Enzyme Commission (EC)Complement subcomponent C1r2.421e-10Highly InformativeDirect
Enzyme Commission (EC)Protein C (activated)1.46e-08Highly InformativeDirect
Enzyme Commission (EC)Coagulation factor Xa1.257e-05Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

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DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.3663Least InformativeInherited
Disease Ontology (DO)artery disease0.02177Moderately InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.05617Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.1539Moderately InformativeInherited
Disease Ontology (DO)skin disease0.6431Moderately InformativeInherited
Disease Ontology (DO)bullous pemphigoid0.0001824InformativeDirect
Disease Ontology (DO)primary thrombocytopenia0.0003435Highly InformativeDirect
Disease Ontology (DO)vesiculobullous skin disease0.0004027Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

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HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the globe0.0263Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the respiratory system0.2077Moderately InformativeInherited
Phenotypic Abnormality (PA)Generalized abnormality of skin0.3709Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper respiratory tract0.03631InformativeInherited
Phenotypic Abnormality (PA)Localized skin lesion0.308InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin morphology0.5736InformativeInherited
Phenotypic Abnormality (PA)Palmar hyperhidrosis2.439e-06Highly InformativeDirect
Phenotypic Abnormality (PA)Laryngeal cyst9.271e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Milia0.0003792Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the anterior chamber0.0005444Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal blistering of the skin0.0267Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the nail0.2567Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

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MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype2.746e-07Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0.1391Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.1545Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.5792Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.5906Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.6252Least InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype4.88e-05Moderately InformativeDirect
Mammalian Phenotype (MP)muscle phenotype5.143e-05Moderately InformativeDirect
Mammalian Phenotype (MP)renal/urinary system phenotype0.0001403Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal blood vessel morphology0.000183Moderately InformativeDirect
Mammalian Phenotype (MP)integument phenotype0.00165Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.01088Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.0309Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.03548Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.05804Moderately InformativeInherited
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.4471Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.5062Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.6046Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic system physiology0.8227Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system physiology0.8952Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell-mediated immunity0.9662Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive immunity0.9786Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune cell physiology0.9864Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation2.537e-06InformativeDirect
Mammalian Phenotype (MP)other phenotype1.058e-05InformativeDirect
Mammalian Phenotype (MP)abnormal leukocyte migration0.0009621InformativeDirect
Mammalian Phenotype (MP)abnormal systemic artery morphology0.02619InformativeInherited
Mammalian Phenotype (MP)abnormal macrophage physiology0.107InformativeInherited
Mammalian Phenotype (MP)abnormal brain development0.3329InformativeInherited
Mammalian Phenotype (MP)abnormal female reproductive system physiology0.4934InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear sensory epithelium morphology0.5341InformativeInherited
Mammalian Phenotype (MP)hemorrhage0.557InformativeInherited
Mammalian Phenotype (MP)abnormal hair cell morphology0.6441InformativeInherited
Mammalian Phenotype (MP)abnormal neuron number0.6544InformativeInherited
Mammalian Phenotype (MP)abnormal membranous labyrinth morphology0.804InformativeInherited
Mammalian Phenotype (MP)dermal-epidermal separation1.084e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cardinal vein morphology0.0001215Highly InformativeDirect
Mammalian Phenotype (MP)absent sebaceous gland0.0003272Highly InformativeDirect
Mammalian Phenotype (MP)abnormal aorta tunica media morphology0.0003907Highly InformativeDirect
Mammalian Phenotype (MP)skin hemorrhage0.0006568Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pregnancy0.0007714Highly InformativeDirect
Mammalian Phenotype (MP)aneurysm0.0007785Highly InformativeDirect
Mammalian Phenotype (MP)decreased organ of Corti supporting cell number0.0009639Highly InformativeDirect
Mammalian Phenotype (MP)abnormal olfactory bulb development0.01598Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear hair cell number0.03408Highly InformativeInherited
Mammalian Phenotype (MP)increased sensory neuron number0.08072Highly InformativeInherited
Mammalian Phenotype (MP)abnormal dorsal root ganglion morphology0.349Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear inner hair cell morphology0.8611Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

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WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.09377Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.5332Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.7574Least InformativeInherited
Worm Phenotype (WP)organ system development variant1.406e-09Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant4.904e-05Moderately InformativeDirect
Worm Phenotype (WP)locomotion variant0.0004116Moderately InformativeDirect
Worm Phenotype (WP)larval lethal0.002104Moderately InformativeInherited
Worm Phenotype (WP)cell death variant0.1289Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.2636Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.5176Moderately InformativeInherited
Worm Phenotype (WP)gametogenesis variant0.6654Moderately InformativeInherited
Worm Phenotype (WP)muscle cell morphology variant9.269e-06InformativeDirect
Worm Phenotype (WP)body length variant0.0001052InformativeDirect
Worm Phenotype (WP)anchor cell invasion variant0.0002273InformativeDirect
Worm Phenotype (WP)somatic gonad development variant0.0003895InformativeDirect
Worm Phenotype (WP)activity level variant0.0005193InformativeDirect
Worm Phenotype (WP)body wall muscle morphology variant0.001095InformativeInherited
Worm Phenotype (WP)protein metabolism variant0.001646InformativeInherited
Worm Phenotype (WP)VPC competence variant0.003412InformativeInherited
Worm Phenotype (WP)cell corpse number variant0.005543InformativeInherited
Worm Phenotype (WP)chemotaxis variant0.01059InformativeInherited
Worm Phenotype (WP)vulva development variant0.01957InformativeInherited
Worm Phenotype (WP)locomotor coordination variant0.06792InformativeInherited
Worm Phenotype (WP)copulation variant0.06917InformativeInherited
Worm Phenotype (WP)protein expression variant0.07409InformativeInherited
Worm Phenotype (WP)neuron development variant0.3556InformativeInherited
Worm Phenotype (WP)male behavior variant1InformativeInherited
Worm Phenotype (WP)muscle arm development defective3.587e-06Highly InformativeDirect
Worm Phenotype (WP)protein degradation variant0.0002093Highly InformativeDirect
Worm Phenotype (WP)roller0.0002282Highly InformativeDirect
Worm Phenotype (WP)developmental morphology variant0.0003415Highly InformativeDirect
Worm Phenotype (WP)accumulated germline cell corpses0.0004667Highly InformativeDirect
Worm Phenotype (WP)loss of asymmetry ASE0.000484Highly InformativeDirect
Worm Phenotype (WP)negative chemotaxis variant0.0006188Highly InformativeDirect
Worm Phenotype (WP)male mating defective0.0006954Highly InformativeDirect
Worm Phenotype (WP)axon guidance variant0.0007544Highly InformativeDirect
Worm Phenotype (WP)germline proliferation variant0.01557Highly InformativeInherited
Worm Phenotype (WP)alimentary system morphology variant0.01712Highly InformativeInherited
Worm Phenotype (WP)level of protein expression variant0.01733Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

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FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0.07073Least InformativeInherited
Fly Phenotype (FP)lethal - all die before end of P-stage0.001913Moderately InformativeInherited
Fly Phenotype (FP)lethal - all die before end of first instar larval stage6.677e-07InformativeDirect
Fly Phenotype (FP)planar polarity defective0.0003653InformativeDirect
Fly Phenotype (FP)increased cell number0.0008113InformativeDirect
Fly Phenotype (FP)lethal - all die before end of embryonic stage2.179e-07Highly InformativeDirect
Fly Phenotype (FP)some die during embryonic stage2.632e-06Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

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