SUPERFAMILY 1.75 HMM library and genome assignments server


EGF/Laminin superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Knottins (small inhibitors, toxins, lectins) [ 57015] (19)
Superfamily:   EGF/Laminin [ 57196] (7)
Families:   EGF-type module [ 57197] (22)
  Integrin beta EGF-like domains [ 69940]
  EGF-like domain of nidogen-1 [ 64541]
  Laminin-type module [ 57233]
  Follistatin (FS) module N-terminal domain, FS-N [ 57236] (2)
  Merozoite surface protein 1 (MSP-1) [ 57239]
  Cripto EGF-like domain-like [ 144100]


Superfamily statistics
Genomes (231) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 67,507 64,657 117
Proteins 20,889 21,997 88


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)developmental process00Least InformativeDirect
Biological Process (BP)multicellular organismal process00Least InformativeDirect
Biological Process (BP)single-organism developmental process00Moderately InformativeDirect
Cellular Component (CC)membrane00Least InformativeDirect
Cellular Component (CC)plasma membrane00Moderately InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism developmental process 0 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 1.53e-14 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 1.288e-12 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 7.346e-10 Moderately Informative Direct
Biological Process (BP) signal transduction 1.955e-09 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 1.306e-07 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 1.803e-07 Moderately Informative Direct
Biological Process (BP) nervous system development 6.421e-07 Moderately Informative Direct
Biological Process (BP) regulation of signaling 7.089e-07 Moderately Informative Direct
Biological Process (BP) cell differentiation 6.038e-06 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 6.427e-06 Moderately Informative Direct
Biological Process (BP) reproduction 1.908e-05 Moderately Informative Direct
Biological Process (BP) immune system process 0.0002341 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.0005772 Moderately Informative Direct
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.03178 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.04806 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 0.5577 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.118 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.446 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.6327 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.9857 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organ development 0.04873 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.05593 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.5223 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.2782 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.4848 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.5044 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.6025 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 0.8761 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular component movement 0 Informative Direct
Biological Process (BP) regulation of cell proliferation 0 Informative Direct
Biological Process (BP) biological adhesion 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) cell projection organization 0 Informative Direct
Biological Process (BP) positive regulation of phosphorus metabolic process 0 Informative Direct
Biological Process (BP) regulation of locomotion 0 Informative Direct
Biological Process (BP) localization of cell 0 Informative Direct
Biological Process (BP) response to wounding 0 Informative Direct
Biological Process (BP) negative regulation of developmental process 4.008e-15 Informative Direct
Biological Process (BP) positive regulation of protein metabolic process 2.073e-11 Informative Direct
Biological Process (BP) cellular component morphogenesis 1.482e-10 Informative Direct
Biological Process (BP) regulation of cellular component movement 1.695e-10 Informative Direct
Biological Process (BP) growth 1.949e-10 Informative Direct
Biological Process (BP) negative regulation of cell communication 1.153e-08 Informative Direct
Biological Process (BP) negative regulation of signaling 1.996e-08 Informative Direct
Biological Process (BP) response to external stimulus 4.509e-08 Informative Direct
Biological Process (BP) regulation of body fluid levels 5.654e-08 Informative Direct
Biological Process (BP) generation of neurons 8.462e-08 Informative Direct
Biological Process (BP) cardiovascular system development 9.253e-07 Informative Direct
Biological Process (BP) regulation of protein phosphorylation 2.595e-06 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 4.803e-06 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 3.247e-05 Informative Direct
Biological Process (BP) gland development 3.759e-05 Informative Direct
Biological Process (BP) positive regulation of catalytic activity 0.0001142 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.0002817 Informative Direct
Biological Process (BP) secretion 0.0002835 Informative Direct
Biological Process (BP) monocarboxylic acid biosynthetic process 0.000497 Informative Direct
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.4129 Informative Inherited
Biological Process (BP) cellular membrane organization 0.2709 Informative Inherited
Biological Process (BP) protein transport 0.00457 Informative Inherited
Biological Process (BP) regulation of cytokine production 1 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) sensory organ development 0.07573 Informative Inherited
Biological Process (BP) regulation of response to stress 1 Informative Inherited
Biological Process (BP) tube development 0.01212 Informative Inherited
Biological Process (BP) epithelium development 0.2198 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 1 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.1701 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.1683 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) synaptic transmission 1 Informative Inherited
Biological Process (BP) regulation of secretion 0.1931 Informative Inherited
Biological Process (BP) embryonic organ development 0.8454 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.1198 Informative Inherited
Biological Process (BP) positive regulation of transport 0.7968 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.09024 Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.01884 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.006755 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.6118 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.008782 Informative Inherited
Biological Process (BP) regulation of cell development 1 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.002718 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.6135 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 1 Informative Inherited
Biological Process (BP) negative regulation of molecular function 1 Informative Inherited
Biological Process (BP) apoptotic process 0.7787 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.5621 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.3078 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.02672 Informative Inherited
Biological Process (BP) response to cytokine stimulus 0.3149 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.01403 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.06023 Informative Inherited
Biological Process (BP) response to organic nitrogen 0.3964 Informative Inherited
Biological Process (BP) regulation of protein localization 0.9364 Informative Inherited
Biological Process (BP) regulation of growth 0.5897 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.9545 Informative Inherited
Biological Process (BP) central nervous system development 0.09391 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.7129 Informative Inherited
Biological Process (BP) multi-organism reproductive process 0.0932 Informative Inherited
Biological Process (BP) protein phosphorylation 0.7753 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.1241 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) steroid metabolic process 0.001163 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.03563 Informative Inherited
Biological Process (BP) lipid transport 0.04356 Informative Inherited
Biological Process (BP) muscle tissue development 0.1664 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.9074 Informative Inherited
Biological Process (BP) response to light stimulus 1 Informative Inherited
Biological Process (BP) single-organism behavior 0.4034 Informative Inherited
Biological Process (BP) single organism reproductive process 0.01331 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) organ morphogenesis 0.001989 Informative Inherited
Biological Process (BP) sexual reproduction 0.168 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.4716 Informative Inherited
Biological Process (BP) nucleocytoplasmic transport 0.6015 Informative Inherited
Biological Process (BP) cytoplasmic transport 1 Informative Inherited
Biological Process (BP) protein localization to organelle 1 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 1 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 1 Informative Inherited
Biological Process (BP) muscle structure development 0.003703 Informative Inherited
Biological Process (BP) blood circulation 1 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.02211 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.01766 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.02622 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.006326 Informative Inherited
Biological Process (BP) chordate embryonic development 0.5226 Informative Inherited
Biological Process (BP) chemotaxis 0 Highly Informative Direct
Biological Process (BP) cell adhesion 0 Highly Informative Direct
Biological Process (BP) icosanoid biosynthetic process 2.076e-15 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 1.019e-13 Highly Informative Direct
Biological Process (BP) unsaturated fatty acid metabolic process 7.893e-10 Highly Informative Direct
Biological Process (BP) regulation of blood pressure 2.882e-09 Highly Informative Direct
Biological Process (BP) regulation of peptidyl-tyrosine phosphorylation 1.216e-08 Highly Informative Direct
Biological Process (BP) plasma membrane organization 1.273e-07 Highly Informative Direct
Biological Process (BP) coagulation 3.707e-07 Highly Informative Direct
Biological Process (BP) positive regulation of protein kinase B signaling cascade 4.483e-07 Highly Informative Direct
Biological Process (BP) mammary gland epithelium development 5.067e-07 Highly Informative Direct
Biological Process (BP) regulation of angiogenesis 5.405e-07 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 8.984e-07 Highly Informative Direct
Biological Process (BP) female gamete generation 2.434e-06 Highly Informative Direct
Biological Process (BP) telencephalon development 2.585e-06 Highly Informative Direct
Biological Process (BP) axonogenesis 3.334e-06 Highly Informative Direct
Biological Process (BP) protein localization to membrane 3.829e-06 Highly Informative Direct
Biological Process (BP) negative regulation of signal transduction 9.743e-06 Highly Informative Direct
Biological Process (BP) positive regulation of intracellular transport 1.235e-05 Highly Informative Direct
Biological Process (BP) developmental growth 1.444e-05 Highly Informative Direct
Biological Process (BP) detection of visible light 2.197e-05 Highly Informative Direct
Biological Process (BP) sterol metabolic process 2.3e-05 Highly Informative Direct
Biological Process (BP) muscle organ development 3.469e-05 Highly Informative Direct
Biological Process (BP) positive regulation of protein transport 3.858e-05 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 4.363e-05 Highly Informative Direct
Biological Process (BP) hormone transport 5.217e-05 Highly Informative Direct
Biological Process (BP) regulation of blood coagulation 0.0001288 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 0.0001459 Highly Informative Direct
Biological Process (BP) phagocytosis 0.0001473 Highly Informative Direct
Biological Process (BP) regulation of interleukin-1 production 0.0001705 Highly Informative Direct
Biological Process (BP) glial cell differentiation 0.0001812 Highly Informative Direct
Biological Process (BP) skeletal system development 0.0001971 Highly Informative Direct
Biological Process (BP) leukocyte migration 0.0002007 Highly Informative Direct
Biological Process (BP) positive regulation of cell cycle process 0.0002931 Highly Informative Direct
Biological Process (BP) aminoglycan catabolic process 0.0005889 Highly Informative Direct
Biological Process (BP) protein activation cascade 0.0008216 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.000893 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.02946 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic process 0.2235 Highly Informative Inherited
Biological Process (BP) regulation of organ morphogenesis 0.4665 Highly Informative Inherited
Biological Process (BP) extracellular matrix organization 1 Highly Informative Inherited
Biological Process (BP) response to drug 0.09833 Highly Informative Inherited
Biological Process (BP) cell fate commitment 0.103 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.8282 Highly Informative Inherited
Biological Process (BP) response to carbohydrate stimulus 0.1056 Highly Informative Inherited
Biological Process (BP) cardiocyte differentiation 0.04557 Highly Informative Inherited
Biological Process (BP) retina development in camera-type eye 0.02536 Highly Informative Inherited
Biological Process (BP) connective tissue development 0.008066 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.01103 Highly Informative Inherited
Biological Process (BP) regulation of behavior 0.07195 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.9575 Highly Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 0.05818 Highly Informative Inherited
Biological Process (BP) negative regulation of secretion 0.001913 Highly Informative Inherited
Biological Process (BP) regulation of protein secretion 0.06603 Highly Informative Inherited
Biological Process (BP) post-embryonic development 1 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.3074 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 1 Highly Informative Inherited
Biological Process (BP) signal release 0.2527 Highly Informative Inherited
Biological Process (BP) regulation of Ras protein signal transduction 0.2476 Highly Informative Inherited
Biological Process (BP) positive regulation of cell differentiation 0.005416 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.7214 Highly Informative Inherited
Biological Process (BP) positive regulation of cell activation 0.3509 Highly Informative Inherited
Biological Process (BP) regulation of lymphocyte activation 0.6289 Highly Informative Inherited
Biological Process (BP) regulation of nitric oxide biosynthetic process 0.001213 Highly Informative Inherited
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.5084 Highly Informative Inherited
Biological Process (BP) regulation of MAP kinase activity 0.01443 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 0.9518 Highly Informative Inherited
Biological Process (BP) positive regulation of protein serine/threonine kinase activity 1 Highly Informative Inherited
Biological Process (BP) negative regulation of endopeptidase activity 0.0277 Highly Informative Inherited
Biological Process (BP) regulation of cysteine-type endopeptidase activity involved in apoptotic process 0.1784 Highly Informative Inherited
Biological Process (BP) limb morphogenesis 0.6074 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.07712 Highly Informative Inherited
Biological Process (BP) photoreceptor cell differentiation 0.9784 Highly Informative Inherited
Biological Process (BP) regulation of protein catabolic process 0.03247 Highly Informative Inherited
Biological Process (BP) gastrulation 0.04166 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.8156 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.7221 Highly Informative Inherited
Biological Process (BP) negative regulation of protein transport 0.2667 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.001097 Highly Informative Inherited
Biological Process (BP) regulation of nucleocytoplasmic transport 0.07665 Highly Informative Inherited
Biological Process (BP) regulation of protein localization to nucleus 0.01229 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular transport 0.017 Highly Informative Inherited
Biological Process (BP) activation of protein kinase activity 1 Highly Informative Inherited
Biological Process (BP) regulation of cell projection organization 0.0221 Highly Informative Inherited
Biological Process (BP) negative regulation of cell development 0.09843 Highly Informative Inherited
Biological Process (BP) negative regulation of cell growth 0.3127 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.6425 Highly Informative Inherited
Biological Process (BP) regulation of cellular component size 0.7641 Highly Informative Inherited
Biological Process (BP) regulation of neuron differentiation 1 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis 1 Highly Informative Inherited
Biological Process (BP) glycosaminoglycan metabolic process 0.04103 Highly Informative Inherited
Biological Process (BP) diencephalon development 0.1019 Highly Informative Inherited
Biological Process (BP) multi-organism cellular process 0.5351 Highly Informative Inherited
Biological Process (BP) peptidyl-serine modification 0.002918 Highly Informative Inherited
Biological Process (BP) organic hydroxy compound transport 0.004287 Highly Informative Inherited
Biological Process (BP) negative regulation of locomotion 0.0194 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular component movement 0.01833 Highly Informative Inherited
Biological Process (BP) inner ear development 0.2151 Highly Informative Inherited
Biological Process (BP) epidermis development 0.5658 Highly Informative Inherited
Biological Process (BP) sensory perception 1 Highly Informative Inherited
Biological Process (BP) multi-multicellular organism process 0.2922 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 1 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.002855 Highly Informative Inherited
Biological Process (BP) protein import 0.07396 Highly Informative Inherited
Biological Process (BP) nuclear import 0.09699 Highly Informative Inherited
Biological Process (BP) protein localization to nucleus 0.1817 Highly Informative Inherited
Biological Process (BP) protein targeting to nucleus 0.4596 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 0.2707 Highly Informative Inherited
Biological Process (BP) cardiac muscle tissue development 0.4086 Highly Informative Inherited
Biological Process (BP) regulation of inflammatory response 1 Highly Informative Inherited
Biological Process (BP) exocytosis 0.5906 Highly Informative Inherited
Biological Process (BP) epithelial tube morphogenesis 0.197 Highly Informative Inherited
Biological Process (BP) tube formation 0.5347 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 1 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) protein binding 0 Moderately Informative Direct
Molecular Function (MF) structural molecule activity 7.321e-14 Moderately Informative Direct
Molecular Function (MF) anion binding 0.9948 Moderately Informative Inherited
Molecular Function (MF) cation binding 0.08215 Moderately Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.5156 Moderately Informative Inherited
Molecular Function (MF) heterocyclic compound binding 1 Moderately Informative Inherited
Molecular Function (MF) organic cyclic compound binding 1 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) receptor binding 0 Informative Direct
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) carboxylic acid binding 3.781e-05 Informative Direct
Molecular Function (MF) lipid binding 0.0002265 Informative Direct
Molecular Function (MF) peptidase regulator activity 0.003388 Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 0.004676 Informative Inherited
Molecular Function (MF) molecular transducer activity 0.06997 Informative Inherited
Molecular Function (MF) enzyme activator activity 0.008312 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 0.8058 Informative Inherited
Molecular Function (MF) inorganic cation transmembrane transporter activity 0.9998 Informative Inherited
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1 Informative Inherited
Molecular Function (MF) peptidase activity 0.01848 Informative Inherited
Molecular Function (MF) calcium ion binding 0 Highly Informative Direct
Molecular Function (MF) glycolipid binding 1.467e-14 Highly Informative Direct
Molecular Function (MF) sulfur compound binding 8.409e-14 Highly Informative Direct
Molecular Function (MF) protein complex binding 5.334e-12 Highly Informative Direct
Molecular Function (MF) modified amino acid binding 9.778e-08 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 5.051e-06 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase inhibitor activity 1.714e-05 Highly Informative Direct
Molecular Function (MF) glycosaminoglycan binding 0.0001429 Highly Informative Direct
Molecular Function (MF) heme binding 0.0001496 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0.0002064 Highly Informative Direct
Molecular Function (MF) serine-type peptidase activity 0.0002544 Highly Informative Direct
Molecular Function (MF) endopeptidase activity 0.0004498 Highly Informative Direct
Molecular Function (MF) peroxidase activity 0.0006672 Highly Informative Direct
Molecular Function (MF) protein kinase regulator activity 0.2321 Highly Informative Inherited
Molecular Function (MF) ion gated channel activity 0.5621 Highly Informative Inherited
Molecular Function (MF) ion channel activity 0.873 Highly Informative Inherited
Molecular Function (MF) protein kinase activity 1 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) extracellular region 0 Moderately Informative Direct
Cellular Component (CC) cell projection 1.688e-07 Moderately Informative Direct
Cellular Component (CC) vesicle 0.0001001 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 0.08807 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.2586 Moderately Informative Inherited
Cellular Component (CC) extracellular matrix 0 Informative Direct
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) cell leading edge 3.236e-07 Informative Direct
Cellular Component (CC) neuron part 1.98e-05 Informative Direct
Cellular Component (CC) cell junction 4.687e-05 Informative Direct
Cellular Component (CC) Golgi apparatus 0.000185 Informative Direct
Cellular Component (CC) vacuole 0.9636 Informative Inherited
Cellular Component (CC) synapse 0.003506 Informative Inherited
Cellular Component (CC) secretory granule 0.01497 Informative Inherited
Cellular Component (CC) intrinsic to plasma membrane 0.005416 Informative Inherited
Cellular Component (CC) integral to membrane 0.175 Informative Inherited
Cellular Component (CC) proteinaceous extracellular matrix 0 Highly Informative Direct
Cellular Component (CC) extracellular matrix part 0 Highly Informative Direct
Cellular Component (CC) receptor complex 4.577e-08 Highly Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 1.06e-06 Highly Informative Direct
Cellular Component (CC) vacuolar lumen 3.981e-06 Highly Informative Direct
Cellular Component (CC) external side of plasma membrane 4.751e-06 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 1.94e-05 Highly Informative Direct
Cellular Component (CC) integral to plasma membrane 5.164e-05 Highly Informative Direct
Cellular Component (CC) cell-substrate junction 9.986e-05 Highly Informative Direct
Cellular Component (CC) adherens junction 0.0001187 Highly Informative Direct
Cellular Component (CC) lipid particle 0.0001863 Highly Informative Direct
Cellular Component (CC) neuromuscular junction 0.000187 Highly Informative Direct
Cellular Component (CC) cytoplasmic vesicle part 0.04677 Highly Informative Inherited
Cellular Component (CC) lysosome 0.08837 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

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EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases0.0002233Least InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Miscellaneous (requires further characterization)0InformativeDirect
Enzyme Commission (EC)Peroxidases6.591e-06InformativeDirect
Enzyme Commission (EC)Coagulation factor IXa2.266e-11Highly InformativeDirect
Enzyme Commission (EC)Complement subcomponent C1s2.421e-10Highly InformativeDirect
Enzyme Commission (EC)Complement subcomponent C1r2.421e-10Highly InformativeDirect
Enzyme Commission (EC)Protein C (activated)1.46e-08Highly InformativeDirect
Enzyme Commission (EC)Coagulation factor Xa1.257e-05Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

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DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.1072Least InformativeInherited
Disease Ontology (DO)immune system disease0.4481Least InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.0365Moderately InformativeInherited
Disease Ontology (DO)brain disease0.0755Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.1751Moderately InformativeInherited
Disease Ontology (DO)vascular disease0.6306Moderately InformativeInherited
Disease Ontology (DO)skin disease0.7527Moderately InformativeInherited
Disease Ontology (DO)bullous pemphigoid0.0001963InformativeDirect
Disease Ontology (DO)cerebrovascular disease0.04467InformativeInherited
Disease Ontology (DO)vesiculobullous skin disease0.0002554Highly InformativeDirect
Disease Ontology (DO)primary thrombocytopenia0.0003669Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

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HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the integument0.279Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the anterior segment of the eye0.005603Moderately InformativeInherited
Phenotypic Abnormality (PA)Generalized abnormality of skin0.4789Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0.5157Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper respiratory tract0.009127InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the nail0.1377InformativeInherited
Phenotypic Abnormality (PA)Localized skin lesion0.2179InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin morphology0.5149InformativeInherited
Phenotypic Abnormality (PA)Palmar hyperhidrosis1.941e-06Highly InformativeDirect
Phenotypic Abnormality (PA)Laryngeal cyst8.784e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Milia0.00039Highly InformativeDirect
Phenotypic Abnormality (PA)Fragile nails0.0004211Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the anterior chamber0.0005993Highly InformativeDirect
Phenotypic Abnormality (PA)Onycholysis0.0008737Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal blistering of the skin0.01636Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

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MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype8.682e-06Least InformativeDirect
Mammalian Phenotype (MP)nervous system phenotype0.1909Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.5062Least InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.0001957Moderately InformativeDirect
Mammalian Phenotype (MP)muscle phenotype0.0005147Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal blood vessel morphology0.0008008Moderately InformativeDirect
Mammalian Phenotype (MP)integument phenotype0.003457Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.03536Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.1995Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.6302Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation5.533e-06InformativeDirect
Mammalian Phenotype (MP)other phenotype5.62e-05InformativeDirect
Mammalian Phenotype (MP)abnormal cochlear sensory epithelium morphology0.256InformativeInherited
Mammalian Phenotype (MP)abnormal artery morphology0.2648InformativeInherited
Mammalian Phenotype (MP)abnormal hair cell morphology0.4024InformativeInherited
Mammalian Phenotype (MP)abnormal neuron number0.4703InformativeInherited
Mammalian Phenotype (MP)hemorrhage0.5629InformativeInherited
Mammalian Phenotype (MP)abnormal membranous labyrinth morphology0.8549InformativeInherited
Mammalian Phenotype (MP)abnormal aorta morphology2.11e-08Highly InformativeDirect
Mammalian Phenotype (MP)dermal-epidermal separation1.498e-05Highly InformativeDirect
Mammalian Phenotype (MP)skin hemorrhage0.0005792Highly InformativeDirect
Mammalian Phenotype (MP)decreased organ of Corti supporting cell number0.0008312Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cochlear hair cell number0.02458Highly InformativeInherited
Mammalian Phenotype (MP)increased sensory neuron number0.05385Highly InformativeInherited
Mammalian Phenotype (MP)abnormal dorsal root ganglion morphology0.368Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear inner hair cell morphology0.9099Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

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WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.09377Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.5332Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.7574Least InformativeInherited
Worm Phenotype (WP)organ system development variant1.406e-09Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant4.904e-05Moderately InformativeDirect
Worm Phenotype (WP)locomotion variant0.0004116Moderately InformativeDirect
Worm Phenotype (WP)larval lethal0.002104Moderately InformativeInherited
Worm Phenotype (WP)cell death variant0.1289Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.2636Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.5176Moderately InformativeInherited
Worm Phenotype (WP)gametogenesis variant0.6654Moderately InformativeInherited
Worm Phenotype (WP)muscle cell morphology variant9.269e-06InformativeDirect
Worm Phenotype (WP)body length variant0.0001052InformativeDirect
Worm Phenotype (WP)anchor cell invasion variant0.0002273InformativeDirect
Worm Phenotype (WP)somatic gonad development variant0.0003895InformativeDirect
Worm Phenotype (WP)activity level variant0.0005193InformativeDirect
Worm Phenotype (WP)body wall muscle morphology variant0.001095InformativeInherited
Worm Phenotype (WP)protein metabolism variant0.001646InformativeInherited
Worm Phenotype (WP)VPC competence variant0.003412InformativeInherited
Worm Phenotype (WP)cell corpse number variant0.005543InformativeInherited
Worm Phenotype (WP)chemotaxis variant0.01059InformativeInherited
Worm Phenotype (WP)vulva development variant0.01957InformativeInherited
Worm Phenotype (WP)locomotor coordination variant0.06792InformativeInherited
Worm Phenotype (WP)copulation variant0.06917InformativeInherited
Worm Phenotype (WP)protein expression variant0.07409InformativeInherited
Worm Phenotype (WP)neuron development variant0.3556InformativeInherited
Worm Phenotype (WP)male behavior variant1InformativeInherited
Worm Phenotype (WP)muscle arm development defective3.587e-06Highly InformativeDirect
Worm Phenotype (WP)protein degradation variant0.0002093Highly InformativeDirect
Worm Phenotype (WP)roller0.0002282Highly InformativeDirect
Worm Phenotype (WP)developmental morphology variant0.0003415Highly InformativeDirect
Worm Phenotype (WP)accumulated germline cell corpses0.0004667Highly InformativeDirect
Worm Phenotype (WP)loss of asymmetry ASE0.000484Highly InformativeDirect
Worm Phenotype (WP)negative chemotaxis variant0.0006188Highly InformativeDirect
Worm Phenotype (WP)male mating defective0.0006954Highly InformativeDirect
Worm Phenotype (WP)axon guidance variant0.0007544Highly InformativeDirect
Worm Phenotype (WP)germline proliferation variant0.01557Highly InformativeInherited
Worm Phenotype (WP)alimentary system morphology variant0.01712Highly InformativeInherited
Worm Phenotype (WP)level of protein expression variant0.01733Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

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FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)planar polarity defective0.0002538InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

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FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0.01536Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.04762Least InformativeInherited
Fly Anatomy (FA)cell0.1665Least InformativeInherited
Fly Anatomy (FA)larva0.2249Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)portion of tissue0.0005974Moderately InformativeDirect
Fly Anatomy (FA)gonad0.01524Moderately InformativeInherited
Fly Anatomy (FA)cell cluster organ0.02342Moderately InformativeInherited
Fly Anatomy (FA)anatomical group0.02481Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.02791Moderately InformativeInherited
Fly Anatomy (FA)appendage0.03397Moderately InformativeInherited
Fly Anatomy (FA)sense organ0.04461Moderately InformativeInherited
Fly Anatomy (FA)cuticle0.08787Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.09116Moderately InformativeInherited
Fly Anatomy (FA)neuron0.1073Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment0.1283Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.1323Moderately InformativeInherited
Fly Anatomy (FA)head0.1396Moderately InformativeInherited
Fly Anatomy (FA)adult thorax0.1401Moderately InformativeInherited
Fly Anatomy (FA)developing material anatomical entity0.3207Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.3257Moderately InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument0.7369Moderately InformativeInherited
Fly Anatomy (FA)primordium0.0006271InformativeDirect
Fly Anatomy (FA)wing blade0.0006331InformativeDirect
Fly Anatomy (FA)muscle system0.0009294InformativeDirect
Fly Anatomy (FA)syncytium0.001321InformativeInherited
Fly Anatomy (FA)muscle cell0.002115InformativeInherited
Fly Anatomy (FA)prepupa0.003913InformativeInherited
Fly Anatomy (FA)digestive system0.00637InformativeInherited
Fly Anatomy (FA)hemocyte0.01222InformativeInherited
Fly Anatomy (FA)integumentary specialisation0.01797InformativeInherited
Fly Anatomy (FA)presumptive embryonic/larval digestive system0.057InformativeInherited
Fly Anatomy (FA)cell component0.08201InformativeInherited
Fly Anatomy (FA)larval abdominal segment0.1202InformativeInherited
Fly Anatomy (FA)extended germ band embryo0.2002InformativeInherited
Fly Anatomy (FA)eye photoreceptor cell0.2092InformativeInherited
Fly Anatomy (FA)dorsal closure embryo0.2409InformativeInherited
Fly Anatomy (FA)testis0.5398InformativeInherited
Fly Anatomy (FA)hub cell3.887e-05Highly InformativeDirect
Fly Anatomy (FA)late extended germ band embryo0.000275Highly InformativeDirect
Fly Anatomy (FA)ventral nervous system0.0003122Highly InformativeDirect
Fly Anatomy (FA)adult heart0.0005621Highly InformativeDirect
Fly Anatomy (FA)head mesoderm derived embryonic hemocyte0.0008975Highly InformativeDirect
Fly Anatomy (FA)embryonic cardioblast0.0009149Highly InformativeDirect
Fly Anatomy (FA)muscle attachment site0.003721Highly InformativeInherited
Fly Anatomy (FA)embryonic/larval circulatory system0.009629Highly InformativeInherited
Fly Anatomy (FA)larval abdominal segment 30.02886Highly InformativeInherited
Fly Anatomy (FA)larval abdominal segment 60.05702Highly InformativeInherited
Fly Anatomy (FA)larval abdominal segment 70.06184Highly InformativeInherited
Fly Anatomy (FA)larval abdominal segment 50.07537Highly InformativeInherited
Fly Anatomy (FA)larval abdominal segment 40.09503Highly InformativeInherited
Fly Anatomy (FA)embryonic/larval midgut0.2101Highly InformativeInherited
Fly Anatomy (FA)longitudinal muscle0.2463Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

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ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)portion of tissue0.0006645Least InformativeDirect
Zebrafish Anatomy (ZA)multi-tissue structure0.05118Least InformativeInherited
Zebrafish Anatomy (ZA)head0.6812Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system0.8118Least InformativeInherited
Zebrafish Anatomy (ZA)cavitated compound organ1Least InformativeInherited
Zebrafish Anatomy (ZA)cranium0.001211Moderately InformativeInherited
Zebrafish Anatomy (ZA)anatomical cluster0.001414Moderately InformativeInherited
Zebrafish Anatomy (ZA)central nervous system0.3068Moderately InformativeInherited
Zebrafish Anatomy (ZA)anatomical surface0.0003293InformativeDirect
Zebrafish Anatomy (ZA)occipital region0.003855InformativeInherited
Zebrafish Anatomy (ZA)brain0.2724InformativeInherited
Zebrafish Anatomy (ZA)rhombomere 43.297e-05Highly InformativeDirect
Zebrafish Anatomy (ZA)notochord0.0008724Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

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XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)portion of tissue0.4094Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo1Least InformativeInherited
Xenopus ANatomical entity (XAN)central nervous system1Least InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.1797Moderately InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.8864Moderately InformativeInherited
Xenopus ANatomical entity (XAN)surface structure0.9829Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)spinal cord0.0126InformativeInherited
Xenopus ANatomical entity (XAN)tail1InformativeInherited
Xenopus ANatomical entity (XAN)axial mesoderm2.454e-05Highly InformativeDirect
Xenopus ANatomical entity (XAN)floor plate4.784e-05Highly InformativeDirect
Xenopus ANatomical entity (XAN)fin0.0197Highly InformativeInherited
Xenopus DEvelopment stage (XDE)embryonic stage1.717e-09Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

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