SUPERFAMILY 1.75 HMM library and genome assignments server

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EGF/Laminin superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Knottins (small inhibitors, toxins, lectins) [ 57015] (19)
Superfamily:   EGF/Laminin [ 57196] (7)
Families:   EGF-type module [ 57197] (22)
  Integrin beta EGF-like domains [ 69940]
  EGF-like domain of nidogen-1 [ 64541]
  Laminin-type module [ 57233]
  Follistatin (FS) module N-terminal domain, FS-N [ 57236] (2)
  Merozoite surface protein 1 (MSP-1) [ 57239]
  Cripto EGF-like domain-like [ 144100]


Superfamily statistics
Genomes (273) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 75,404 77,955 117
Proteins 23,667 26,553 88


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)developmental process00Least InformativeDirect
Biological Process (BP)multicellular organismal process00Least InformativeDirect
Biological Process (BP)single-organism developmental process00Moderately InformativeDirect
Cellular Component (CC)membrane00Least InformativeDirect
Cellular Component (CC)plasma membrane00Moderately InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism developmental process 0 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0 Moderately Informative Direct
Biological Process (BP) nervous system development 0.0000000003801 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.00000001622 Moderately Informative Direct
Biological Process (BP) signal transduction 0.00000008362 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 0.0000002349 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0.000001043 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.00004936 Moderately Informative Direct
Biological Process (BP) immune system process 0.00005347 Moderately Informative Direct
Biological Process (BP) reproduction 0.00009127 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.00009271 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 0.0001054 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.000808 Moderately Informative Direct
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.53 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.05075 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 0.5164 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.06031 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.002034 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.6706 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organ development 0.0114 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.1709 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.4188 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.4001 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.1571 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.04669 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.645 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 0.8659 Moderately Informative Inherited
Biological Process (BP) single-organism biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular component movement 0 Informative Direct
Biological Process (BP) regulation of cellular component movement 0 Informative Direct
Biological Process (BP) biological adhesion 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) cell projection organization 0 Informative Direct
Biological Process (BP) regulation of locomotion 0 Informative Direct
Biological Process (BP) localization of cell 0 Informative Direct
Biological Process (BP) negative regulation of developmental process 0 Informative Direct
Biological Process (BP) response to wounding 0 Informative Direct
Biological Process (BP) regulation of cell proliferation 0.00000000000001429 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.000000000000356 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 0.0000000000006015 Informative Direct
Biological Process (BP) cardiovascular system development 0.000000000001277 Informative Direct
Biological Process (BP) growth 0.00000000001724 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.00000000003737 Informative Direct
Biological Process (BP) organ morphogenesis 0.000000002425 Informative Direct
Biological Process (BP) positive regulation of protein modification process 0.000000002932 Informative Direct
Biological Process (BP) generation of neurons 0.00000002305 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.0000003768 Informative Direct
Biological Process (BP) regulation of body fluid levels 0.000001981 Informative Direct
Biological Process (BP) tissue morphogenesis 0.000002068 Informative Direct
Biological Process (BP) tube development 0.000004144 Informative Direct
Biological Process (BP) regulation of protein phosphorylation 0.000005479 Informative Direct
Biological Process (BP) positive regulation of developmental process 0.00001265 Informative Direct
Biological Process (BP) regulation of growth 0.00001742 Informative Direct
Biological Process (BP) regulation of peptidase activity 0.00001893 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.00003951 Informative Direct
Biological Process (BP) embryonic morphogenesis 0.00007705 Informative Direct
Biological Process (BP) negative regulation of signaling 0.0002183 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.0002378 Informative Direct
Biological Process (BP) defense response 0.0005967 Informative Direct
Biological Process (BP) monocarboxylic acid biosynthetic process 0.0006445 Informative Direct
Biological Process (BP) gland development 0.0006474 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0.000917 Informative Direct
Biological Process (BP) regulation of nervous system development 0.0009498 Informative Direct
Biological Process (BP) cellular membrane organization 0.0009607 Informative Direct
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.5565 Informative Inherited
Biological Process (BP) protein transport 0.003467 Informative Inherited
Biological Process (BP) regulation of cytokine production 1 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.8908 Informative Inherited
Biological Process (BP) muscle tissue development 0.3167 Informative Inherited
Biological Process (BP) muscle structure development 0.007254 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.6283 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) sensory organ development 0.1236 Informative Inherited
Biological Process (BP) embryonic organ development 0.002494 Informative Inherited
Biological Process (BP) epithelium development 0.5664 Informative Inherited
Biological Process (BP) protein oligomerization 0.002512 Informative Inherited
Biological Process (BP) synaptic transmission 1 Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 0.3386 Informative Inherited
Biological Process (BP) regulation of secretion 0.1705 Informative Inherited
Biological Process (BP) negative regulation of transport 0.2928 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.9394 Informative Inherited
Biological Process (BP) single-organism behavior 0.01914 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.2904 Informative Inherited
Biological Process (BP) positive regulation of transport 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.02029 Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.01582 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.002748 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.01169 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.3473 Informative Inherited
Biological Process (BP) regulation of cell development 0.1573 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.009093 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.5514 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 1 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.7911 Informative Inherited
Biological Process (BP) apoptotic process 0.2529 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.6584 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.04691 Informative Inherited
Biological Process (BP) response to cytokine stimulus 0.6431 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.01259 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.01912 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.08379 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.6132 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 0.1901 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.02267 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.1604 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.08014 Informative Inherited
Biological Process (BP) central nervous system development 0.2088 Informative Inherited
Biological Process (BP) phosphorylation 1 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.2102 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.1814 Informative Inherited
Biological Process (BP) lipid localization 1 Informative Inherited
Biological Process (BP) regulation of hormone levels 1 Informative Inherited
Biological Process (BP) response to light stimulus 0.939 Informative Inherited
Biological Process (BP) response to nutrient levels 0.2842 Informative Inherited
Biological Process (BP) multi-multicellular organism process 0.8934 Informative Inherited
Biological Process (BP) single organism reproductive process 0.1937 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) sexual reproduction 0.322 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.3479 Informative Inherited
Biological Process (BP) cytoplasmic transport 1 Informative Inherited
Biological Process (BP) protein localization to organelle 1 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 1 Informative Inherited
Biological Process (BP) blood circulation 1 Informative Inherited
Biological Process (BP) secretion by cell 0.2795 Informative Inherited
Biological Process (BP) immune response 0.7542 Informative Inherited
Biological Process (BP) immune effector process 0.842 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.002928 Informative Inherited
Biological Process (BP) chemotaxis 0 Highly Informative Direct
Biological Process (BP) cell adhesion 0 Highly Informative Direct
Biological Process (BP) fatty acid derivative biosynthetic process 0.000000000000001931 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 0.00000000000001604 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0.00000000000002112 Highly Informative Direct
Biological Process (BP) cell junction organization 0.00000000002096 Highly Informative Direct
Biological Process (BP) icosanoid metabolic process 0.00000000002438 Highly Informative Direct
Biological Process (BP) positive regulation of protein kinase activity 0.0000000002357 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.0000000004164 Highly Informative Direct
Biological Process (BP) unsaturated fatty acid metabolic process 0.0000000008078 Highly Informative Direct
Biological Process (BP) regulation of wound healing 0.000000000942 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 0.000000001846 Highly Informative Direct
Biological Process (BP) neuron projection development 0.00000002614 Highly Informative Direct
Biological Process (BP) cell part morphogenesis 0.00000004271 Highly Informative Direct
Biological Process (BP) pattern specification process 0.00000006796 Highly Informative Direct
Biological Process (BP) skeletal system development 0.00000006849 Highly Informative Direct
Biological Process (BP) regulation of mitosis 0.00000009209 Highly Informative Direct
Biological Process (BP) positive regulation of peptidyl-tyrosine phosphorylation 0.0000001208 Highly Informative Direct
Biological Process (BP) regulation of blood pressure 0.0000001517 Highly Informative Direct
Biological Process (BP) protein activation cascade 0.0000002586 Highly Informative Direct
Biological Process (BP) regulation of cell size 0.0000002719 Highly Informative Direct
Biological Process (BP) telencephalon development 0.0000003209 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0.0000004268 Highly Informative Direct
Biological Process (BP) regulation of striated muscle tissue development 0.0000005016 Highly Informative Direct
Biological Process (BP) regulation of behavior 0.00000129 Highly Informative Direct
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.000001403 Highly Informative Direct
Biological Process (BP) humoral immune response 0.000002105 Highly Informative Direct
Biological Process (BP) mammary gland epithelium development 0.000002254 Highly Informative Direct
Biological Process (BP) female gamete generation 0.000003326 Highly Informative Direct
Biological Process (BP) coagulation 0.000005704 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0.000007561 Highly Informative Direct
Biological Process (BP) regulation of protein kinase B signaling cascade 0.00001376 Highly Informative Direct
Biological Process (BP) sterol metabolic process 0.00002415 Highly Informative Direct
Biological Process (BP) female pregnancy 0.00003513 Highly Informative Direct
Biological Process (BP) regulation of coagulation 0.00005287 Highly Informative Direct
Biological Process (BP) hormone transport 0.00005718 Highly Informative Direct
Biological Process (BP) phagocytosis 0.0001056 Highly Informative Direct
Biological Process (BP) muscle organ development 0.0001168 Highly Informative Direct
Biological Process (BP) positive regulation of intracellular transport 0.000132 Highly Informative Direct
Biological Process (BP) detection of light stimulus 0.000178 Highly Informative Direct
Biological Process (BP) negative regulation of cell growth 0.0002407 Highly Informative Direct
Biological Process (BP) positive regulation of response to external stimulus 0.0002839 Highly Informative Direct
Biological Process (BP) developmental growth 0.0002958 Highly Informative Direct
Biological Process (BP) regulation of hemostasis 0.0002967 Highly Informative Direct
Biological Process (BP) muscle fiber development 0.000335 Highly Informative Direct
Biological Process (BP) leukocyte migration 0.0004119 Highly Informative Direct
Biological Process (BP) positive regulation of homeostatic process 0.0005256 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 0.0005652 Highly Informative Direct
Biological Process (BP) aminoglycan catabolic process 0.0006169 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.0006483 Highly Informative Direct
Biological Process (BP) respiratory system development 0.0007644 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.1471 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic process 0.4824 Highly Informative Inherited
Biological Process (BP) regulation of organ morphogenesis 0.9394 Highly Informative Inherited
Biological Process (BP) extracellular matrix organization 1 Highly Informative Inherited
Biological Process (BP) response to drug 0.003855 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.4457 Highly Informative Inherited
Biological Process (BP) carbohydrate homeostasis 0.06152 Highly Informative Inherited
Biological Process (BP) response to carbohydrate stimulus 0.1702 Highly Informative Inherited
Biological Process (BP) mesenchyme development 0.1538 Highly Informative Inherited
Biological Process (BP) cardiocyte differentiation 0.1149 Highly Informative Inherited
Biological Process (BP) retina development in camera-type eye 0.01116 Highly Informative Inherited
Biological Process (BP) connective tissue development 0.01788 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.1186 Highly Informative Inherited
Biological Process (BP) protein tetramerization 0.5888 Highly Informative Inherited
Biological Process (BP) sensory perception 1 Highly Informative Inherited
Biological Process (BP) regulation of endocytosis 0.3561 Highly Informative Inherited
Biological Process (BP) negative regulation of secretion 0.002154 Highly Informative Inherited
Biological Process (BP) regulation of cytokine secretion 0.1171 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.003371 Highly Informative Inherited
Biological Process (BP) positive regulation of neurogenesis 0.02115 Highly Informative Inherited
Biological Process (BP) post-embryonic development 1 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.01294 Highly Informative Inherited
Biological Process (BP) signal release 0.4791 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 0.009592 Highly Informative Inherited
Biological Process (BP) regulation of cell adhesion 0.001429 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cell activation 0.756 Highly Informative Inherited
Biological Process (BP) regulation of nitric oxide biosynthetic process 0.001025 Highly Informative Inherited
Biological Process (BP) cell fate commitment 0.02265 Highly Informative Inherited
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.6404 Highly Informative Inherited
Biological Process (BP) regulation of MAP kinase activity 0.005257 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 1 Highly Informative Inherited
Biological Process (BP) negative regulation of endopeptidase activity 0.03258 Highly Informative Inherited
Biological Process (BP) regulation of cysteine-type endopeptidase activity involved in apoptotic process 0.2554 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.5476 Highly Informative Inherited
Biological Process (BP) regulation of protein catabolic process 0.04417 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 1 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.8783 Highly Informative Inherited
Biological Process (BP) response to purine-containing compound 0.007352 Highly Informative Inherited
Biological Process (BP) negative regulation of protein transport 0.277 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.002221 Highly Informative Inherited
Biological Process (BP) regulation of nucleocytoplasmic transport 0.0943 Highly Informative Inherited
Biological Process (BP) regulation of protein localization to nucleus 0.09018 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular transport 0.01762 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 1 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 1 Highly Informative Inherited
Biological Process (BP) limb morphogenesis 0.3927 Highly Informative Inherited
Biological Process (BP) glycosaminoglycan metabolic process 0.03419 Highly Informative Inherited
Biological Process (BP) glial cell differentiation 0.001566 Highly Informative Inherited
Biological Process (BP) membrane fusion 1 Highly Informative Inherited
Biological Process (BP) multi-organism cellular process 0.6427 Highly Informative Inherited
Biological Process (BP) peptidyl-serine modification 0.0027 Highly Informative Inherited
Biological Process (BP) protein phosphorylation 1 Highly Informative Inherited
Biological Process (BP) regulation of angiogenesis 0.003484 Highly Informative Inherited
Biological Process (BP) organic hydroxy compound transport 0.00542 Highly Informative Inherited
Biological Process (BP) ear development 0.9197 Highly Informative Inherited
Biological Process (BP) epidermal cell differentiation 0.06763 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.547 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.6524 Highly Informative Inherited
Biological Process (BP) protein import 0.05194 Highly Informative Inherited
Biological Process (BP) nuclear import 0.06847 Highly Informative Inherited
Biological Process (BP) protein localization to nucleus 0.151 Highly Informative Inherited
Biological Process (BP) protein targeting to nucleus 0.408 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 0.01429 Highly Informative Inherited
Biological Process (BP) cardiac muscle tissue development 0.6668 Highly Informative Inherited
Biological Process (BP) exocytosis 0.9063 Highly Informative Inherited
Biological Process (BP) innate immune response 0.1093 Highly Informative Inherited
Biological Process (BP) neural tube development 0.616 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 1 Highly Informative Inherited
Biological Process (BP) epithelial tube formation 1 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) structural molecule activity 0.000000000000226 Moderately Informative Direct
Molecular Function (MF) anion binding 0.4946 Moderately Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.3301 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) cation binding 0.4748 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) receptor binding 0 Informative Direct
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.000000000000001557 Informative Direct
Molecular Function (MF) sulfur compound binding 0.000000000001039 Informative Direct
Molecular Function (MF) carboxylic acid binding 0.00003824 Informative Direct
Molecular Function (MF) tetrapyrrole binding 0.0001767 Informative Direct
Molecular Function (MF) peptidase regulator activity 0.0002334 Informative Direct
Molecular Function (MF) enzyme inhibitor activity 0.0005102 Informative Direct
Molecular Function (MF) protein dimerization activity 0.8322 Informative Inherited
Molecular Function (MF) molecular transducer activity 0.02003 Informative Inherited
Molecular Function (MF) enzyme activator activity 0.006014 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 0.7824 Informative Inherited
Molecular Function (MF) inorganic cation transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1 Informative Inherited
Molecular Function (MF) peptidase activity 0.008313 Informative Inherited
Molecular Function (MF) enzyme binding 1 Informative Inherited
Molecular Function (MF) lipid binding 0.001413 Informative Inherited
Molecular Function (MF) calcium ion binding 0 Highly Informative Direct
Molecular Function (MF) glycolipid binding 0.000000000000009694 Highly Informative Direct
Molecular Function (MF) heparin binding 0.00000000000007437 Highly Informative Direct
Molecular Function (MF) protein complex binding 0.00000000002471 Highly Informative Direct
Molecular Function (MF) serine hydrolase activity 0.0000039 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 0.000005452 Highly Informative Direct
Molecular Function (MF) endopeptidase activity 0.00007489 Highly Informative Direct
Molecular Function (MF) heme binding 0.0001217 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0.000225 Highly Informative Direct
Molecular Function (MF) protein heterodimerization activity 0.0005388 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on peroxide as acceptor 0.0007111 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase inhibitor activity 0.0009297 Highly Informative Direct
Molecular Function (MF) amino acid binding 0.3355 Highly Informative Inherited
Molecular Function (MF) protein kinase regulator activity 0.2353 Highly Informative Inherited
Molecular Function (MF) calcium ion transmembrane transporter activity 0.04726 Highly Informative Inherited
Molecular Function (MF) cation channel activity 0.5043 Highly Informative Inherited
Molecular Function (MF) ion gated channel activity 0.5621 Highly Informative Inherited
Molecular Function (MF) growth factor receptor binding 0.001738 Highly Informative Inherited
Molecular Function (MF) protein kinase activity 1 Highly Informative Inherited
Molecular Function (MF) antioxidant activity 0.01742 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.6096 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0.000000000000003092 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 0.2563 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.008365 Moderately Informative Inherited
Cellular Component (CC) extracellular membrane-bounded organelle 0 Informative Direct
Cellular Component (CC) extracellular matrix 0 Informative Direct
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) cell leading edge 0.00000006532 Informative Direct
Cellular Component (CC) cell junction 0.000002091 Informative Direct
Cellular Component (CC) Golgi apparatus 0.00002361 Informative Direct
Cellular Component (CC) endosome 0.0004584 Informative Direct
Cellular Component (CC) vacuolar part 0.005191 Informative Inherited
Cellular Component (CC) lytic vacuole 0.002855 Informative Inherited
Cellular Component (CC) secretory granule 0.02755 Informative Inherited
Cellular Component (CC) integral to membrane 0.4002 Informative Inherited
Cellular Component (CC) intrinsic to plasma membrane 0.05735 Informative Inherited
Cellular Component (CC) proteinaceous extracellular matrix 0 Highly Informative Direct
Cellular Component (CC) extracellular matrix part 0 Highly Informative Direct
Cellular Component (CC) receptor complex 0.00000000000001473 Highly Informative Direct
Cellular Component (CC) adherens junction 0.00000007267 Highly Informative Direct
Cellular Component (CC) sarcoplasmic reticulum 0.000004876 Highly Informative Direct
Cellular Component (CC) external side of plasma membrane 0.00001442 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.00005585 Highly Informative Direct
Cellular Component (CC) lysosome 0.0004092 Highly Informative Direct
Cellular Component (CC) cell projection membrane 0.001347 Highly Informative Inherited
Cellular Component (CC) ion channel complex 1 Highly Informative Inherited
Cellular Component (CC) membrane raft 0.2427 Highly Informative Inherited
Cellular Component (CC) integral to plasma membrane 0.001211 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

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EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases0.0002233Least InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Miscellaneous (requires further characterization)0InformativeDirect
Enzyme Commission (EC)Peroxidases0.000006591InformativeDirect
Enzyme Commission (EC)Coagulation factor IXa0.00000000002266Highly InformativeDirect
Enzyme Commission (EC)Complement subcomponent C1s0.0000000002421Highly InformativeDirect
Enzyme Commission (EC)Complement subcomponent C1r0.0000000002421Highly InformativeDirect
Enzyme Commission (EC)Protein C (activated)0.0000000146Highly InformativeDirect
Enzyme Commission (EC)Coagulation factor Xa0.00001257Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

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DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.3864Least InformativeInherited
Disease Ontology (DO)artery disease0.02165Moderately InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.05552Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.1511Moderately InformativeInherited
Disease Ontology (DO)skin disease0.6252Moderately InformativeInherited
Disease Ontology (DO)bullous pemphigoid0.0002354InformativeDirect
Disease Ontology (DO)atherosclerosis0.0004667InformativeDirect
Disease Ontology (DO)primary thrombocytopenia0.0004578Highly InformativeDirect
Disease Ontology (DO)vesiculobullous skin disease0.0005415Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

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HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the globe0.04096Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0.09857Moderately InformativeInherited
Phenotypic Abnormality (PA)Generalized abnormality of skin0.3458Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the urinary system0.4867Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper respiratory tract0.005708InformativeInherited
Phenotypic Abnormality (PA)Localized skin lesion0.349InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin morphology0.6817InformativeInherited
Phenotypic Abnormality (PA)Palmar hyperhidrosis0.000002959Highly InformativeDirect
Phenotypic Abnormality (PA)Milia0.0003833Highly InformativeDirect
Phenotypic Abnormality (PA)Laryngeal cyst0.0005207Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the anterior chamber0.0005416Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal blistering of the skin0.02558Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower urinary tract0.06321Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the nail0.2604Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

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MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.0000001893Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0.09008Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.14Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.362Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.5386Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.5981Least InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.00005749Moderately InformativeDirect
Mammalian Phenotype (MP)muscle phenotype0.00006366Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal blood vessel morphology0.0001081Moderately InformativeDirect
Mammalian Phenotype (MP)renal/urinary system phenotype0.0001585Moderately InformativeDirect
Mammalian Phenotype (MP)integument phenotype0.001691Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.006617Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.01165Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.01648Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.02357Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.5109Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.564Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell physiology0.6361Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.6585Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system physiology0.8931Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell-mediated immunity0.9801Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive immunity0.9905Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune cell physiology0.9954Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation0.000002527InformativeDirect
Mammalian Phenotype (MP)abnormal leukocyte migration0.0008905InformativeDirect
Mammalian Phenotype (MP)abnormal systemic artery morphology0.02628InformativeInherited
Mammalian Phenotype (MP)abnormal macrophage physiology0.1117InformativeInherited
Mammalian Phenotype (MP)abnormal angiogenesis0.1318InformativeInherited
Mammalian Phenotype (MP)abnormal brain development0.3185InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear sensory epithelium morphology0.5013InformativeInherited
Mammalian Phenotype (MP)abnormal female reproductive system physiology0.5154InformativeInherited
Mammalian Phenotype (MP)hemorrhage0.539InformativeInherited
Mammalian Phenotype (MP)abnormal hair cell morphology0.5959InformativeInherited
Mammalian Phenotype (MP)abnormal neuron number0.72InformativeInherited
Mammalian Phenotype (MP)abnormal membranous labyrinth morphology0.7689InformativeInherited
Mammalian Phenotype (MP)abnormal basement membrane morphology0.00000008932Highly InformativeDirect
Mammalian Phenotype (MP)dermal-epidermal separation0.00002081Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cardinal vein morphology0.0001151Highly InformativeDirect
Mammalian Phenotype (MP)absent sebaceous gland0.0003115Highly InformativeDirect
Mammalian Phenotype (MP)abnormal aorta tunica media morphology0.0004286Highly InformativeDirect
Mammalian Phenotype (MP)skin hemorrhage0.0006197Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pregnancy0.0007503Highly InformativeDirect
Mammalian Phenotype (MP)aneurysm0.0008261Highly InformativeDirect
Mammalian Phenotype (MP)decreased organ of Corti supporting cell number0.0009335Highly InformativeDirect
Mammalian Phenotype (MP)abnormal olfactory bulb development0.01799Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear hair cell number0.06085Highly InformativeInherited
Mammalian Phenotype (MP)increased sensory neuron number0.08755Highly InformativeInherited
Mammalian Phenotype (MP)abnormal dorsal root ganglion morphology0.3425Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear inner hair cell morphology0.9389Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

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WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.09377Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.5332Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.7574Least InformativeInherited
Worm Phenotype (WP)organ system development variant0.000000001406Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.00004904Moderately InformativeDirect
Worm Phenotype (WP)locomotion variant0.0004116Moderately InformativeDirect
Worm Phenotype (WP)larval lethal0.002104Moderately InformativeInherited
Worm Phenotype (WP)cell death variant0.1289Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.2636Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.5176Moderately InformativeInherited
Worm Phenotype (WP)gametogenesis variant0.6654Moderately InformativeInherited
Worm Phenotype (WP)muscle cell morphology variant0.000009269InformativeDirect
Worm Phenotype (WP)body length variant0.0001052InformativeDirect
Worm Phenotype (WP)anchor cell invasion variant0.0002273InformativeDirect
Worm Phenotype (WP)somatic gonad development variant0.0003895InformativeDirect
Worm Phenotype (WP)activity level variant0.0005193InformativeDirect
Worm Phenotype (WP)body wall muscle morphology variant0.001095InformativeInherited
Worm Phenotype (WP)protein metabolism variant0.001646InformativeInherited
Worm Phenotype (WP)VPC competence variant0.003412InformativeInherited
Worm Phenotype (WP)cell corpse number variant0.005543InformativeInherited
Worm Phenotype (WP)chemotaxis variant0.01059InformativeInherited
Worm Phenotype (WP)vulva development variant0.01957InformativeInherited
Worm Phenotype (WP)locomotor coordination variant0.06792InformativeInherited
Worm Phenotype (WP)copulation variant0.06917InformativeInherited
Worm Phenotype (WP)protein expression variant0.07409InformativeInherited
Worm Phenotype (WP)neuron development variant0.3556InformativeInherited
Worm Phenotype (WP)male behavior variant1InformativeInherited
Worm Phenotype (WP)muscle arm development defective0.000003587Highly InformativeDirect
Worm Phenotype (WP)protein degradation variant0.0002093Highly InformativeDirect
Worm Phenotype (WP)roller0.0002282Highly InformativeDirect
Worm Phenotype (WP)developmental morphology variant0.0003415Highly InformativeDirect
Worm Phenotype (WP)accumulated germline cell corpses0.0004667Highly InformativeDirect
Worm Phenotype (WP)loss of asymmetry ASE0.000484Highly InformativeDirect
Worm Phenotype (WP)negative chemotaxis variant0.0006188Highly InformativeDirect
Worm Phenotype (WP)male mating defective0.0006954Highly InformativeDirect
Worm Phenotype (WP)axon guidance variant0.0007544Highly InformativeDirect
Worm Phenotype (WP)germline proliferation variant0.01557Highly InformativeInherited
Worm Phenotype (WP)alimentary system morphology variant0.01712Highly InformativeInherited
Worm Phenotype (WP)level of protein expression variant0.01733Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

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FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0.6047Least InformativeInherited
Fly Phenotype (FP)lethal - all die before end of P-stage0.0004715Moderately InformativeDirect
Fly Phenotype (FP)lethal - all die before end of larval stage0.00001163InformativeDirect
Fly Phenotype (FP)lethal - all die before end of embryonic stage0.00000006951Highly InformativeDirect
Fly Phenotype (FP)some die during embryonic stage0.0000005411Highly InformativeDirect
Fly Phenotype (FP)planar polarity defective0.0008713Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

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FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0.01028Least InformativeInherited
Fly Anatomy (FA)adult0.02569Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.03253Least InformativeInherited
Fly Anatomy (FA)larva0.07145Least InformativeInherited
Fly Anatomy (FA)cell0.156Least InformativeInherited
Fly Anatomy (FA)anatomical group0.2424Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)acellular anatomical structure0.0002429Moderately InformativeDirect
Fly Anatomy (FA)appendage0.01706Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.0242Moderately InformativeInherited
Fly Anatomy (FA)external sensory organ0.03927Moderately InformativeInherited
Fly Anatomy (FA)adult thorax0.0465Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.05456Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.06297Moderately InformativeInherited
Fly Anatomy (FA)reproductive system0.09332Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.09603Moderately InformativeInherited
Fly Anatomy (FA)adult sense organ0.1028Moderately InformativeInherited
Fly Anatomy (FA)adult nervous system0.1422Moderately InformativeInherited
Fly Anatomy (FA)sensillum0.144Moderately InformativeInherited
Fly Anatomy (FA)neuron0.1453Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment0.1909Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.2116Moderately InformativeInherited
Fly Anatomy (FA)developing material anatomical entity0.3192Moderately InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument0.3805Moderately InformativeInherited
Fly Anatomy (FA)adult head0.503Moderately InformativeInherited
Fly Anatomy (FA)syncytium0.0004242InformativeDirect
Fly Anatomy (FA)primordium0.0005628InformativeDirect
Fly Anatomy (FA)wing blade0.000672InformativeDirect
Fly Anatomy (FA)alimentary canal0.0007157InformativeDirect
Fly Anatomy (FA)muscle cell0.0008316InformativeDirect
Fly Anatomy (FA)midgut0.0009494InformativeDirect
Fly Anatomy (FA)muscle system0.00141InformativeInherited
Fly Anatomy (FA)circulatory system0.001595InformativeInherited
Fly Anatomy (FA)ommatidium0.002773InformativeInherited
Fly Anatomy (FA)sensory organ cell0.00314InformativeInherited
Fly Anatomy (FA)embryonic/larval digestive system0.003635InformativeInherited
Fly Anatomy (FA)prepupa0.004236InformativeInherited
Fly Anatomy (FA)histaminergic neuron0.006558InformativeInherited
Fly Anatomy (FA)optic lobe neuron0.009058InformativeInherited
Fly Anatomy (FA)integumentary specialisation0.01798InformativeInherited
Fly Anatomy (FA)presumptive embryonic/larval digestive system0.02994InformativeInherited
Fly Anatomy (FA)larval abdominal segment0.0394InformativeInherited
Fly Anatomy (FA)cell component0.09099InformativeInherited
Fly Anatomy (FA)rhabdomeric photoreceptor cell0.2019InformativeInherited
Fly Anatomy (FA)extended germ band embryo0.2502InformativeInherited
Fly Anatomy (FA)dorsal closure embryo0.3081InformativeInherited
Fly Anatomy (FA)male reproductive system0.519InformativeInherited
Fly Anatomy (FA)hub cell0.00002581Highly InformativeDirect
Fly Anatomy (FA)ventral nervous system0.0002939Highly InformativeDirect
Fly Anatomy (FA)muscle attachment site0.003899Highly InformativeInherited
Fly Anatomy (FA)larval abdominal segment 30.1187Highly InformativeInherited
Fly Anatomy (FA)larval abdominal segment 60.16Highly InformativeInherited
Fly Anatomy (FA)embryonic/larval midgut0.1656Highly InformativeInherited
Fly Anatomy (FA)larval abdominal segment 70.1672Highly InformativeInherited
Fly Anatomy (FA)larval abdominal segment 50.1956Highly InformativeInherited
Fly Anatomy (FA)longitudinal muscle0.2139Highly InformativeInherited
Fly Anatomy (FA)larval abdominal segment 40.2266Highly InformativeInherited

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

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