SUPERFAMILY 1.75 HMM library and genome assignments server


EGF/Laminin superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Knottins (small inhibitors, toxins, lectins) [ 57015] (19)
Superfamily:   EGF/Laminin [ 57196] (7)
Families:   EGF-type module [ 57197] (22)
  Integrin beta EGF-like domains [ 69940]
  EGF-like domain of nidogen-1 [ 64541]
  Laminin-type module [ 57233]
  Follistatin (FS) module N-terminal domain, FS-N [ 57236] (2)
  Merozoite surface protein 1 (MSP-1) [ 57239]
  Cripto EGF-like domain-like [ 144100]


Superfamily statistics
Genomes (273) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 75,404 77,955 117
Proteins 23,667 26,553 88


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)developmental process00Least InformativeDirect
Biological Process (BP)multicellular organismal process00Least InformativeDirect
Cellular Component (CC)membrane00Least InformativeDirect
Cellular Component (CC)plasma membrane00Moderately InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0 Moderately Informative Direct
Biological Process (BP) nervous system development 3.23e-10 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 1.525e-08 Moderately Informative Direct
Biological Process (BP) signal transduction 1.175e-07 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 2.026e-07 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 5.845e-07 Moderately Informative Direct
Biological Process (BP) immune system process 4.078e-05 Moderately Informative Direct
Biological Process (BP) regulation of localization 4.341e-05 Moderately Informative Direct
Biological Process (BP) reproduction 6.96e-05 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 8.928e-05 Moderately Informative Direct
Biological Process (BP) cell differentiation 9.679e-05 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.0007371 Moderately Informative Direct
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.5145 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 0.4597 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.05314 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.001686 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.6416 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of programmed cell death 0.114 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organ development 0.01096 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.1404 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.3981 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.4005 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.1817 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.04771 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.5847 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 0.82 Moderately Informative Inherited
Biological Process (BP) single-organism biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular component movement 0 Informative Direct
Biological Process (BP) regulation of cellular component movement 0 Informative Direct
Biological Process (BP) biological adhesion 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) cell projection organization 0 Informative Direct
Biological Process (BP) regulation of locomotion 0 Informative Direct
Biological Process (BP) localization of cell 0 Informative Direct
Biological Process (BP) negative regulation of developmental process 0 Informative Direct
Biological Process (BP) response to wounding 0 Informative Direct
Biological Process (BP) cellular component morphogenesis 4.603e-13 Informative Direct
Biological Process (BP) cardiovascular system development 1.138e-12 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 2.938e-12 Informative Direct
Biological Process (BP) growth 5.758e-12 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 3.317e-11 Informative Direct
Biological Process (BP) organ morphogenesis 2.834e-09 Informative Direct
Biological Process (BP) positive regulation of protein modification process 1.632e-08 Informative Direct
Biological Process (BP) generation of neurons 2.441e-08 Informative Direct
Biological Process (BP) vesicle-mediated transport 2.198e-07 Informative Direct
Biological Process (BP) regulation of anatomical structure size 4.156e-07 Informative Direct
Biological Process (BP) positive regulation of cell proliferation 7.855e-07 Informative Direct
Biological Process (BP) tissue morphogenesis 1.444e-06 Informative Direct
Biological Process (BP) regulation of body fluid levels 2.108e-06 Informative Direct
Biological Process (BP) tube development 4.62e-06 Informative Direct
Biological Process (BP) regulation of protein phosphorylation 5.462e-06 Informative Direct
Biological Process (BP) regulation of growth 1.643e-05 Informative Direct
Biological Process (BP) regulation of peptidase activity 1.644e-05 Informative Direct
Biological Process (BP) positive regulation of developmental process 1.756e-05 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 4.066e-05 Informative Direct
Biological Process (BP) embryonic morphogenesis 8.884e-05 Informative Direct
Biological Process (BP) negative regulation of signaling 0.0002409 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.0002637 Informative Direct
Biological Process (BP) monocarboxylic acid biosynthetic process 0.0004637 Informative Direct
Biological Process (BP) defense response 0.000661 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0.0006953 Informative Direct
Biological Process (BP) gland development 0.0007183 Informative Direct
Biological Process (BP) cellular membrane organization 0.0009612 Informative Direct
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.5496 Informative Inherited
Biological Process (BP) protein transport 0.002788 Informative Inherited
Biological Process (BP) regulation of cytokine production 1 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.8787 Informative Inherited
Biological Process (BP) muscle tissue development 0.3169 Informative Inherited
Biological Process (BP) muscle structure development 0.007297 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) sensory organ development 0.1302 Informative Inherited
Biological Process (BP) embryonic organ development 0.002427 Informative Inherited
Biological Process (BP) epithelium development 0.5656 Informative Inherited
Biological Process (BP) protein complex assembly 0.1666 Informative Inherited
Biological Process (BP) synaptic transmission 1 Informative Inherited
Biological Process (BP) regulation of secretion 0.1645 Informative Inherited
Biological Process (BP) negative regulation of transport 0.2839 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.001064 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.9539 Informative Inherited
Biological Process (BP) single-organism behavior 0.01774 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.2808 Informative Inherited
Biological Process (BP) positive regulation of transport 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.02374 Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.01269 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.003597 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.01019 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.3436 Informative Inherited
Biological Process (BP) regulation of cell development 0.1635 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.008497 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.562 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 1 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.8042 Informative Inherited
Biological Process (BP) apoptotic process 0.2416 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.6814 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.04726 Informative Inherited
Biological Process (BP) response to cytokine stimulus 0.6309 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.02028 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.08758 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.6208 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 0.1913 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.02269 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.1605 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.07701 Informative Inherited
Biological Process (BP) central nervous system development 0.1924 Informative Inherited
Biological Process (BP) phosphorylation 1 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.1924 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.1631 Informative Inherited
Biological Process (BP) lipid localization 1 Informative Inherited
Biological Process (BP) regulation of hormone levels 1 Informative Inherited
Biological Process (BP) response to light stimulus 0.9381 Informative Inherited
Biological Process (BP) response to nutrient levels 0.2307 Informative Inherited
Biological Process (BP) multi-multicellular organism process 0.8989 Informative Inherited
Biological Process (BP) single organism reproductive process 0.2026 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) sexual reproduction 0.3337 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.3487 Informative Inherited
Biological Process (BP) cytoplasmic transport 1 Informative Inherited
Biological Process (BP) protein localization to organelle 1 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 1 Informative Inherited
Biological Process (BP) blood circulation 1 Informative Inherited
Biological Process (BP) secretion by cell 0.2747 Informative Inherited
Biological Process (BP) immune response 0.7722 Informative Inherited
Biological Process (BP) immune effector process 0.8504 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.003165 Informative Inherited
Biological Process (BP) chemotaxis 0 Highly Informative Direct
Biological Process (BP) cell adhesion 0 Highly Informative Direct
Biological Process (BP) fatty acid derivative biosynthetic process 1.944e-15 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 7.377e-15 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 4.131e-14 Highly Informative Direct
Biological Process (BP) icosanoid metabolic process 2.15e-11 Highly Informative Direct
Biological Process (BP) cell junction organization 2.39e-11 Highly Informative Direct
Biological Process (BP) positive regulation of protein kinase activity 8.902e-11 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 5.57e-10 Highly Informative Direct
Biological Process (BP) unsaturated fatty acid metabolic process 7.141e-10 Highly Informative Direct
Biological Process (BP) regulation of wound healing 8.848e-10 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 2.547e-09 Highly Informative Direct
Biological Process (BP) skeletal system development 7.842e-08 Highly Informative Direct
Biological Process (BP) pattern specification process 8e-08 Highly Informative Direct
Biological Process (BP) regulation of mitosis 8.191e-08 Highly Informative Direct
Biological Process (BP) positive regulation of peptidyl-tyrosine phosphorylation 1.165e-07 Highly Informative Direct
Biological Process (BP) regulation of blood pressure 1.646e-07 Highly Informative Direct
Biological Process (BP) protein activation cascade 2.738e-07 Highly Informative Direct
Biological Process (BP) regulation of cell size 3.278e-07 Highly Informative Direct
Biological Process (BP) telencephalon development 3.416e-07 Highly Informative Direct
Biological Process (BP) regulation of striated muscle tissue development 4.436e-07 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 4.778e-07 Highly Informative Direct
Biological Process (BP) regulation of behavior 1.507e-06 Highly Informative Direct
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 1.613e-06 Highly Informative Direct
Biological Process (BP) humoral immune response 2.087e-06 Highly Informative Direct
Biological Process (BP) mammary gland epithelium development 2.216e-06 Highly Informative Direct
Biological Process (BP) female gamete generation 3.557e-06 Highly Informative Direct
Biological Process (BP) coagulation 5.37e-06 Highly Informative Direct
Biological Process (BP) regulation of protein kinase B signaling cascade 1.424e-05 Highly Informative Direct
Biological Process (BP) sterol metabolic process 1.896e-05 Highly Informative Direct
Biological Process (BP) female pregnancy 3.509e-05 Highly Informative Direct
Biological Process (BP) hormone transport 5.038e-05 Highly Informative Direct
Biological Process (BP) regulation of coagulation 5.762e-05 Highly Informative Direct
Biological Process (BP) muscle organ development 7.477e-05 Highly Informative Direct
Biological Process (BP) phagocytosis 0.000109 Highly Informative Direct
Biological Process (BP) positive regulation of response to external stimulus 0.0001162 Highly Informative Direct
Biological Process (BP) positive regulation of intracellular transport 0.0001374 Highly Informative Direct
Biological Process (BP) detection of light stimulus 0.0001677 Highly Informative Direct
Biological Process (BP) negative regulation of cell growth 0.0002587 Highly Informative Direct
Biological Process (BP) developmental growth 0.0002651 Highly Informative Direct
Biological Process (BP) regulation of hemostasis 0.0003202 Highly Informative Direct
Biological Process (BP) muscle fiber development 0.0003345 Highly Informative Direct
Biological Process (BP) leukocyte migration 0.0003792 Highly Informative Direct
Biological Process (BP) positive regulation of homeostatic process 0.0005387 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.0005745 Highly Informative Direct
Biological Process (BP) aminoglycan catabolic process 0.000588 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 0.0008084 Highly Informative Direct
Biological Process (BP) respiratory system development 0.0008733 Highly Informative Direct
Biological Process (BP) regulation of nitric oxide biosynthetic process 0.0009823 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.1523 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic process 0.4732 Highly Informative Inherited
Biological Process (BP) regulation of organ morphogenesis 0.9458 Highly Informative Inherited
Biological Process (BP) cell projection morphogenesis 0.02306 Highly Informative Inherited
Biological Process (BP) extracellular matrix organization 1 Highly Informative Inherited
Biological Process (BP) response to drug 0.00391 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.4489 Highly Informative Inherited
Biological Process (BP) carbohydrate homeostasis 0.04501 Highly Informative Inherited
Biological Process (BP) response to carbohydrate stimulus 0.1743 Highly Informative Inherited
Biological Process (BP) mesenchyme development 0.1502 Highly Informative Inherited
Biological Process (BP) cardiocyte differentiation 0.1153 Highly Informative Inherited
Biological Process (BP) retina development in camera-type eye 0.01216 Highly Informative Inherited
Biological Process (BP) connective tissue development 0.0173 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.1083 Highly Informative Inherited
Biological Process (BP) protein tetramerization 0.5828 Highly Informative Inherited
Biological Process (BP) sensory perception 1 Highly Informative Inherited
Biological Process (BP) regulation of endocytosis 0.3483 Highly Informative Inherited
Biological Process (BP) negative regulation of secretion 0.002259 Highly Informative Inherited
Biological Process (BP) regulation of cytokine secretion 0.1177 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.003131 Highly Informative Inherited
Biological Process (BP) positive regulation of neurogenesis 0.02582 Highly Informative Inherited
Biological Process (BP) post-embryonic development 1 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.01433 Highly Informative Inherited
Biological Process (BP) signal release 0.4871 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 0.009885 Highly Informative Inherited
Biological Process (BP) regulation of cell adhesion 0.001432 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cell activation 0.7561 Highly Informative Inherited
Biological Process (BP) cell fate commitment 0.017 Highly Informative Inherited
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.5647 Highly Informative Inherited
Biological Process (BP) regulation of MAP kinase activity 0.005695 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 1 Highly Informative Inherited
Biological Process (BP) negative regulation of endopeptidase activity 0.03222 Highly Informative Inherited
Biological Process (BP) regulation of cysteine-type endopeptidase activity involved in apoptotic process 0.263 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.573 Highly Informative Inherited
Biological Process (BP) photoreceptor cell differentiation 1 Highly Informative Inherited
Biological Process (BP) regulation of protein catabolic process 0.04392 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 1 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.877 Highly Informative Inherited
Biological Process (BP) response to purine-containing compound 0.007435 Highly Informative Inherited
Biological Process (BP) negative regulation of protein transport 0.2804 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.002412 Highly Informative Inherited
Biological Process (BP) regulation of nucleocytoplasmic transport 0.1001 Highly Informative Inherited
Biological Process (BP) regulation of protein localization to nucleus 0.09655 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular transport 0.01844 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 1 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 1 Highly Informative Inherited
Biological Process (BP) limb morphogenesis 0.3958 Highly Informative Inherited
Biological Process (BP) glycosaminoglycan metabolic process 0.03077 Highly Informative Inherited
Biological Process (BP) membrane fusion 1 Highly Informative Inherited
Biological Process (BP) multi-organism cellular process 0.6451 Highly Informative Inherited
Biological Process (BP) peptidyl-serine modification 0.002661 Highly Informative Inherited
Biological Process (BP) protein phosphorylation 1 Highly Informative Inherited
Biological Process (BP) regulation of angiogenesis 0.003764 Highly Informative Inherited
Biological Process (BP) organic hydroxy compound transport 0.005085 Highly Informative Inherited
Biological Process (BP) ear development 0.9115 Highly Informative Inherited
Biological Process (BP) epidermal cell differentiation 0.07096 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in neuron differentiation 0.1523 Highly Informative Inherited
Biological Process (BP) axon development 0.002986 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.5451 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.6566 Highly Informative Inherited
Biological Process (BP) protein import 0.04826 Highly Informative Inherited
Biological Process (BP) nuclear import 0.06558 Highly Informative Inherited
Biological Process (BP) protein localization to nucleus 0.1455 Highly Informative Inherited
Biological Process (BP) protein targeting to nucleus 0.4097 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 0.01437 Highly Informative Inherited
Biological Process (BP) cardiac muscle tissue development 0.6757 Highly Informative Inherited
Biological Process (BP) exocytosis 0.9009 Highly Informative Inherited
Biological Process (BP) innate immune response 0.1169 Highly Informative Inherited
Biological Process (BP) neural tube development 0.6247 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 1 Highly Informative Inherited
Biological Process (BP) epithelial tube formation 1 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) structural molecule activity 1.693e-13 Moderately Informative Direct
Molecular Function (MF) anion binding 0.5313 Moderately Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.3077 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) cation binding 0.4409 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) receptor binding 0 Informative Direct
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) carbohydrate derivative binding 2.332e-15 Informative Direct
Molecular Function (MF) sulfur compound binding 9.434e-13 Informative Direct
Molecular Function (MF) carboxylic acid binding 3.5e-05 Informative Direct
Molecular Function (MF) tetrapyrrole binding 0.0001328 Informative Direct
Molecular Function (MF) peptidase regulator activity 0.0002131 Informative Direct
Molecular Function (MF) enzyme inhibitor activity 0.0004581 Informative Direct
Molecular Function (MF) protein dimerization activity 0.8396 Informative Inherited
Molecular Function (MF) molecular transducer activity 0.01774 Informative Inherited
Molecular Function (MF) enzyme activator activity 0.00517 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 0.7695 Informative Inherited
Molecular Function (MF) inorganic cation transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1 Informative Inherited
Molecular Function (MF) peptidase activity 0.007446 Informative Inherited
Molecular Function (MF) enzyme binding 1 Informative Inherited
Molecular Function (MF) lipid binding 0.001437 Informative Inherited
Molecular Function (MF) calcium ion binding 0 Highly Informative Direct
Molecular Function (MF) glycolipid binding 8.278e-15 Highly Informative Direct
Molecular Function (MF) heparin binding 9.122e-14 Highly Informative Direct
Molecular Function (MF) protein complex binding 2.346e-11 Highly Informative Direct
Molecular Function (MF) serine hydrolase activity 3.495e-06 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 5.145e-06 Highly Informative Direct
Molecular Function (MF) endopeptidase activity 6.792e-05 Highly Informative Direct
Molecular Function (MF) heme binding 8.837e-05 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0.0001717 Highly Informative Direct
Molecular Function (MF) protein heterodimerization activity 0.0005482 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on peroxide as acceptor 0.0005959 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase inhibitor activity 0.0009305 Highly Informative Direct
Molecular Function (MF) amino acid binding 0.342 Highly Informative Inherited
Molecular Function (MF) protein kinase regulator activity 0.2345 Highly Informative Inherited
Molecular Function (MF) calcium ion transmembrane transporter activity 0.04553 Highly Informative Inherited
Molecular Function (MF) cation channel activity 0.4949 Highly Informative Inherited
Molecular Function (MF) ion gated channel activity 0.5517 Highly Informative Inherited
Molecular Function (MF) growth factor receptor binding 0.001512 Highly Informative Inherited
Molecular Function (MF) protein kinase activity 1 Highly Informative Inherited
Molecular Function (MF) antioxidant activity 0.01518 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.5591 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) vesicle 1.61e-15 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 0.3036 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.007516 Moderately Informative Inherited
Cellular Component (CC) extracellular membrane-bounded organelle 0 Informative Direct
Cellular Component (CC) extracellular matrix 0 Informative Direct
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) cell leading edge 5.915e-08 Informative Direct
Cellular Component (CC) Golgi apparatus 2.117e-05 Informative Direct
Cellular Component (CC) endosome 0.0003546 Informative Direct
Cellular Component (CC) vacuolar part 0.004783 Informative Inherited
Cellular Component (CC) lytic vacuole 0.002711 Informative Inherited
Cellular Component (CC) secretory granule 0.02847 Informative Inherited
Cellular Component (CC) intrinsic to plasma membrane 0.05914 Informative Inherited
Cellular Component (CC) integral to membrane 0.4136 Informative Inherited
Cellular Component (CC) proteinaceous extracellular matrix 0 Highly Informative Direct
Cellular Component (CC) extracellular matrix part 0 Highly Informative Direct
Cellular Component (CC) receptor complex 1.207e-14 Highly Informative Direct
Cellular Component (CC) adherens junction 6.483e-08 Highly Informative Direct
Cellular Component (CC) cell-substrate junction 9.14e-07 Highly Informative Direct
Cellular Component (CC) sarcoplasmic reticulum 4.865e-06 Highly Informative Direct
Cellular Component (CC) external side of plasma membrane 1.564e-05 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 4.109e-05 Highly Informative Direct
Cellular Component (CC) lysosome 0.0003717 Highly Informative Direct
Cellular Component (CC) cell projection membrane 0.0008441 Highly Informative Direct
Cellular Component (CC) integral to plasma membrane 0.0009604 Highly Informative Direct
Cellular Component (CC) ion channel complex 1 Highly Informative Inherited
Cellular Component (CC) membrane raft 0.2387 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

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EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases0.0002233Least InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Miscellaneous (requires further characterization)0InformativeDirect
Enzyme Commission (EC)Peroxidases6.591e-06InformativeDirect
Enzyme Commission (EC)Coagulation factor IXa2.266e-11Highly InformativeDirect
Enzyme Commission (EC)Complement subcomponent C1s2.421e-10Highly InformativeDirect
Enzyme Commission (EC)Complement subcomponent C1r2.421e-10Highly InformativeDirect
Enzyme Commission (EC)Protein C (activated)1.46e-08Highly InformativeDirect
Enzyme Commission (EC)Coagulation factor Xa1.257e-05Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

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DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.3853Least InformativeInherited
Disease Ontology (DO)artery disease0.02172Moderately InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.05784Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.1534Moderately InformativeInherited
Disease Ontology (DO)skin disease0.6384Moderately InformativeInherited
Disease Ontology (DO)bullous pemphigoid0.0001871InformativeDirect
Disease Ontology (DO)primary thrombocytopenia0.0003502Highly InformativeDirect
Disease Ontology (DO)vesiculobullous skin disease0.0004055Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

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HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.09114Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the globe0.02536Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0.1114Moderately InformativeInherited
Phenotypic Abnormality (PA)Generalized abnormality of skin0.3746Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the urinary system0.5341Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper respiratory tract0.01054InformativeInherited
Phenotypic Abnormality (PA)Localized skin lesion0.3033InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin morphology0.5833InformativeInherited
Phenotypic Abnormality (PA)Palmar hyperhidrosis2.341e-06Highly InformativeDirect
Phenotypic Abnormality (PA)Milia0.0003741Highly InformativeDirect
Phenotypic Abnormality (PA)Laryngeal cyst0.000515Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the anterior chamber0.0005344Highly InformativeDirect
Phenotypic Abnormality (PA)Urinary bladder inflammation0.0008383Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal blistering of the skin0.02593Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the nail0.256Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

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MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype1.897e-07Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0.08892Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.1408Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.3913Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.5348Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.5988Least InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype5.892e-05Moderately InformativeDirect
Mammalian Phenotype (MP)muscle phenotype6.553e-05Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal blood vessel morphology9.898e-05Moderately InformativeDirect
Mammalian Phenotype (MP)renal/urinary system phenotype0.0001679Moderately InformativeDirect
Mammalian Phenotype (MP)integument phenotype0.00174Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.006319Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.01228Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.01615Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.02335Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.5045Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.5666Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell physiology0.634Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.66Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system physiology0.896Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell-mediated immunity0.9803Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive immunity0.9909Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune cell physiology0.9956Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation2.308e-06InformativeDirect
Mammalian Phenotype (MP)abnormal leukocyte migration0.0009082InformativeDirect
Mammalian Phenotype (MP)abnormal systemic artery morphology0.02697InformativeInherited
Mammalian Phenotype (MP)abnormal macrophage physiology0.1086InformativeInherited
Mammalian Phenotype (MP)abnormal angiogenesis0.1272InformativeInherited
Mammalian Phenotype (MP)abnormal brain development0.3214InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear sensory epithelium morphology0.4941InformativeInherited
Mammalian Phenotype (MP)abnormal female reproductive system physiology0.519InformativeInherited
Mammalian Phenotype (MP)hemorrhage0.5446InformativeInherited
Mammalian Phenotype (MP)abnormal hair cell morphology0.5809InformativeInherited
Mammalian Phenotype (MP)abnormal neuron number0.7209InformativeInherited
Mammalian Phenotype (MP)abnormal membranous labyrinth morphology0.7648InformativeInherited
Mammalian Phenotype (MP)abnormal basement membrane morphology9.132e-08Highly InformativeDirect
Mammalian Phenotype (MP)dermal-epidermal separation1.061e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cardinal vein morphology0.0001171Highly InformativeDirect
Mammalian Phenotype (MP)absent sebaceous gland0.0003095Highly InformativeDirect
Mammalian Phenotype (MP)abnormal aorta tunica media morphology0.0004346Highly InformativeDirect
Mammalian Phenotype (MP)skin hemorrhage0.0006207Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pregnancy0.0007639Highly InformativeDirect
Mammalian Phenotype (MP)aneurysm0.0008366Highly InformativeDirect
Mammalian Phenotype (MP)decreased organ of Corti supporting cell number0.0009406Highly InformativeDirect
Mammalian Phenotype (MP)abnormal olfactory bulb development0.01802Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear hair cell number0.06707Highly InformativeInherited
Mammalian Phenotype (MP)increased sensory neuron number0.08949Highly InformativeInherited
Mammalian Phenotype (MP)abnormal dorsal root ganglion morphology0.3571Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear inner hair cell morphology0.9306Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

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WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.09377Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.5332Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.7574Least InformativeInherited
Worm Phenotype (WP)organ system development variant1.406e-09Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant4.904e-05Moderately InformativeDirect
Worm Phenotype (WP)locomotion variant0.0004116Moderately InformativeDirect
Worm Phenotype (WP)larval lethal0.002104Moderately InformativeInherited
Worm Phenotype (WP)cell death variant0.1289Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.2636Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.5176Moderately InformativeInherited
Worm Phenotype (WP)gametogenesis variant0.6654Moderately InformativeInherited
Worm Phenotype (WP)muscle cell morphology variant9.269e-06InformativeDirect
Worm Phenotype (WP)body length variant0.0001052InformativeDirect
Worm Phenotype (WP)anchor cell invasion variant0.0002273InformativeDirect
Worm Phenotype (WP)somatic gonad development variant0.0003895InformativeDirect
Worm Phenotype (WP)activity level variant0.0005193InformativeDirect
Worm Phenotype (WP)body wall muscle morphology variant0.001095InformativeInherited
Worm Phenotype (WP)protein metabolism variant0.001646InformativeInherited
Worm Phenotype (WP)VPC competence variant0.003412InformativeInherited
Worm Phenotype (WP)cell corpse number variant0.005543InformativeInherited
Worm Phenotype (WP)chemotaxis variant0.01059InformativeInherited
Worm Phenotype (WP)vulva development variant0.01957InformativeInherited
Worm Phenotype (WP)locomotor coordination variant0.06792InformativeInherited
Worm Phenotype (WP)copulation variant0.06917InformativeInherited
Worm Phenotype (WP)protein expression variant0.07409InformativeInherited
Worm Phenotype (WP)neuron development variant0.3556InformativeInherited
Worm Phenotype (WP)male behavior variant1InformativeInherited
Worm Phenotype (WP)muscle arm development defective3.587e-06Highly InformativeDirect
Worm Phenotype (WP)protein degradation variant0.0002093Highly InformativeDirect
Worm Phenotype (WP)roller0.0002282Highly InformativeDirect
Worm Phenotype (WP)developmental morphology variant0.0003415Highly InformativeDirect
Worm Phenotype (WP)accumulated germline cell corpses0.0004667Highly InformativeDirect
Worm Phenotype (WP)loss of asymmetry ASE0.000484Highly InformativeDirect
Worm Phenotype (WP)negative chemotaxis variant0.0006188Highly InformativeDirect
Worm Phenotype (WP)male mating defective0.0006954Highly InformativeDirect
Worm Phenotype (WP)axon guidance variant0.0007544Highly InformativeDirect
Worm Phenotype (WP)germline proliferation variant0.01557Highly InformativeInherited
Worm Phenotype (WP)alimentary system morphology variant0.01712Highly InformativeInherited
Worm Phenotype (WP)level of protein expression variant0.01733Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

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FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0.6168Least InformativeInherited
Fly Phenotype (FP)lethal - all die before end of P-stage0.0004855Moderately InformativeDirect
Fly Phenotype (FP)lethal - all die before end of larval stage1.248e-05InformativeDirect
Fly Phenotype (FP)lethal - all die before end of embryonic stage7.186e-08Highly InformativeDirect
Fly Phenotype (FP)some die during embryonic stage5.628e-07Highly InformativeDirect
Fly Phenotype (FP)planar polarity defective0.0009437Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

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