SUPERFAMILY 1.75 HMM library and genome assignments server

EGF/Laminin superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Knottins (small inhibitors, toxins, lectins) [ 57015] (19)
Superfamily:   EGF/Laminin [ 57196] (7)
Families:   EGF-type module [ 57197] (22)
  Integrin beta EGF-like domains [ 69940]
  EGF-like domain of nidogen-1 [ 64541]
  Laminin-type module [ 57233]
  Follistatin (FS) module N-terminal domain, FS-N [ 57236] (2)
  Merozoite surface protein 1 (MSP-1) [ 57239]
  Cripto EGF-like domain-like [ 144100]


Superfamily statistics
Genomes (274) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 75,414 77,955 117
Proteins 23,674 26,553 88


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process00Least InformativeDirect
Biological Process (BP)developmental process00Least InformativeDirect
Cellular Component (CC)membrane00Least InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.00000000000187 Least Informative Direct
Biological Process (BP) positive regulation of biological process 0.0002444 Least Informative Direct
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0 Moderately Informative Direct
Biological Process (BP) nervous system development 0.0000000001765 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 0.00000002942 Moderately Informative Direct
Biological Process (BP) signal transduction 0.0000001572 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.000000254 Moderately Informative Direct
Biological Process (BP) regulation of phosphorus metabolic process 0.00003234 Moderately Informative Direct
Biological Process (BP) immune system process 0.00005676 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.00006129 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.00007128 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 0.00008573 Moderately Informative Direct
Biological Process (BP) defense response 0.0002035 Moderately Informative Direct
Biological Process (BP) reproductive process 0.0002907 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.0006406 Moderately Informative Direct
Biological Process (BP) organic substance transport 0.336 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.85 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.5067 Moderately Informative Inherited
Biological Process (BP) organ development 0.04309 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.283 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.9637 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.1509 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.001007 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.03439 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.711 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.2815 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.2428 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.2314 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.1332 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.03203 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.2753 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) cell projection organization 0 Informative Direct
Biological Process (BP) regulation of cell proliferation 0 Informative Direct
Biological Process (BP) biological adhesion 0 Informative Direct
Biological Process (BP) localization of cell 0 Informative Direct
Biological Process (BP) regulation of locomotion 0 Informative Direct
Biological Process (BP) negative regulation of developmental process 0 Informative Direct
Biological Process (BP) cellular component movement 0 Informative Direct
Biological Process (BP) regulation of cellular component movement 0 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 0.00000000000006627 Informative Direct
Biological Process (BP) cardiovascular system development 0.0000000000004517 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.000000000003225 Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.000000000009832 Informative Direct
Biological Process (BP) organ morphogenesis 0.00000000001712 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.00000000008405 Informative Direct
Biological Process (BP) growth 0.0000000003186 Informative Direct
Biological Process (BP) regulation of protein phosphorylation 0.00000001367 Informative Direct
Biological Process (BP) regulation of transferase activity 0.00000002078 Informative Direct
Biological Process (BP) generation of neurons 0.00000002904 Informative Direct
Biological Process (BP) tissue morphogenesis 0.00000007221 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.0000001527 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.0000002322 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.0000004838 Informative Direct
Biological Process (BP) regulation of body fluid levels 0.000002287 Informative Direct
Biological Process (BP) embryonic morphogenesis 0.000002743 Informative Direct
Biological Process (BP) positive regulation of developmental process 0.000005659 Informative Direct
Biological Process (BP) regulation of growth 0.00000947 Informative Direct
Biological Process (BP) regulation of response to wounding 0.00002036 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.00003892 Informative Direct
Biological Process (BP) tube development 0.00004654 Informative Direct
Biological Process (BP) single-organism cellular localization 0.0001055 Informative Direct
Biological Process (BP) regulation of peptidase activity 0.0001091 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 0.0001642 Informative Direct
Biological Process (BP) negative regulation of signaling 0.0002661 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.0004073 Informative Direct
Biological Process (BP) embryonic organ development 0.0005163 Informative Direct
Biological Process (BP) monocarboxylic acid biosynthetic process 0.0006535 Informative Direct
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.3219 Informative Inherited
Biological Process (BP) regulation of protein localization 0.7195 Informative Inherited
Biological Process (BP) apoptotic process 0.1762 Informative Inherited
Biological Process (BP) negative regulation of transport 0.3104 Informative Inherited
Biological Process (BP) regulation of secretion 0.1832 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.8216 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.01158 Informative Inherited
Biological Process (BP) protein transport 0.6967 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 1 Informative Inherited
Biological Process (BP) response to oxidative stress 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) response to inorganic substance 1 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.6113 Informative Inherited
Biological Process (BP) cellular response to external stimulus 1 Informative Inherited
Biological Process (BP) response to nutrient levels 0.3394 Informative Inherited
Biological Process (BP) sensory organ development 0.03914 Informative Inherited
Biological Process (BP) gland development 0.004991 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.0172 Informative Inherited
Biological Process (BP) positive regulation of intracellular signal transduction 0.3562 Informative Inherited
Biological Process (BP) protein oligomerization 0.001837 Informative Inherited
Biological Process (BP) neurological system process 1 Informative Inherited
Biological Process (BP) synaptic transmission 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.001018 Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 0.3987 Informative Inherited
Biological Process (BP) regulation of cell development 0.1414 Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.01934 Informative Inherited
Biological Process (BP) secretion by cell 0.08871 Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.01593 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.02512 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.333 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) regulation of MAPK cascade 0.9194 Informative Inherited
Biological Process (BP) negative regulation of protein processing 0.08293 Informative Inherited
Biological Process (BP) negative regulation of cellular protein metabolic process 0.4291 Informative Inherited
Biological Process (BP) response to cytokine 0.6458 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.08304 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.6023 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.4269 Informative Inherited
Biological Process (BP) regulation of cell activation 1 Informative Inherited
Biological Process (BP) regulation of cytokine production 1 Informative Inherited
Biological Process (BP) positive regulation of transport 1 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.2675 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.03249 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.0349 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.1724 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.2332 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.09621 Informative Inherited
Biological Process (BP) central nervous system development 0.215 Informative Inherited
Biological Process (BP) phosphorylation 1 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.2257 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.2077 Informative Inherited
Biological Process (BP) organic hydroxy compound transport 0.01339 Informative Inherited
Biological Process (BP) lipid localization 1 Informative Inherited
Biological Process (BP) epithelium development 0.03747 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.00272 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.004334 Informative Inherited
Biological Process (BP) regulation of hormone levels 1 Informative Inherited
Biological Process (BP) response to light stimulus 0.8832 Informative Inherited
Biological Process (BP) single-organism behavior 0.006566 Informative Inherited
Biological Process (BP) multi-multicellular organism process 0.9023 Informative Inherited
Biological Process (BP) muscle structure development 0.08748 Informative Inherited
Biological Process (BP) sexual reproduction 0.1916 Informative Inherited
Biological Process (BP) single organism reproductive process 0.1766 Informative Inherited
Biological Process (BP) single-organism intracellular transport 0.2325 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) protein localization to organelle 1 Informative Inherited
Biological Process (BP) cytoplasmic transport 1 Informative Inherited
Biological Process (BP) immune response 0.7141 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 1 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 1 Informative Inherited
Biological Process (BP) blood circulation 1 Informative Inherited
Biological Process (BP) single-organism membrane organization 0.006745 Informative Inherited
Biological Process (BP) immune effector process 0.8472 Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0 Highly Informative Direct
Biological Process (BP) cell recognition 0 Highly Informative Direct
Biological Process (BP) chemotaxis 0 Highly Informative Direct
Biological Process (BP) fatty acid derivative biosynthetic process 0.000000000000001913 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 0.00000000000001752 Highly Informative Direct
Biological Process (BP) cell junction organization 0.000000000000194 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.000000000001689 Highly Informative Direct
Biological Process (BP) icosanoid metabolic process 0.00000000002362 Highly Informative Direct
Biological Process (BP) positive regulation of protein kinase activity 0.0000000001864 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 0.0000000003315 Highly Informative Direct
Biological Process (BP) positive regulation of mitotic cell cycle 0.0000000004828 Highly Informative Direct
Biological Process (BP) unsaturated fatty acid metabolic process 0.000000000818 Highly Informative Direct
Biological Process (BP) protein activation cascade 0.000000001652 Highly Informative Direct
Biological Process (BP) regulation of peptidyl-tyrosine phosphorylation 0.00000001129 Highly Informative Direct
Biological Process (BP) neuron projection development 0.00000001396 Highly Informative Direct
Biological Process (BP) skeletal system development 0.00000004992 Highly Informative Direct
Biological Process (BP) regulation of blood pressure 0.00000007101 Highly Informative Direct
Biological Process (BP) regulation of chemotaxis 0.00000007283 Highly Informative Direct
Biological Process (BP) plasma membrane organization 0.0000003384 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0.0000003453 Highly Informative Direct
Biological Process (BP) pattern specification process 0.0000004666 Highly Informative Direct
Biological Process (BP) regulation of cell size 0.0000007492 Highly Informative Direct
Biological Process (BP) telencephalon development 0.000001034 Highly Informative Direct
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.000001442 Highly Informative Direct
Biological Process (BP) humoral immune response 0.000002002 Highly Informative Direct
Biological Process (BP) female gamete generation 0.000003537 Highly Informative Direct
Biological Process (BP) positive regulation of behavior 0.000004372 Highly Informative Direct
Biological Process (BP) coagulation 0.000007197 Highly Informative Direct
Biological Process (BP) regulation of wound healing 0.00000822 Highly Informative Direct
Biological Process (BP) mammary gland epithelium development 0.00001329 Highly Informative Direct
Biological Process (BP) regulation of nuclear division 0.00001571 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0.00002123 Highly Informative Direct
Biological Process (BP) sterol metabolic process 0.00002332 Highly Informative Direct
Biological Process (BP) negative regulation of nervous system development 0.00003389 Highly Informative Direct
Biological Process (BP) sterol transport 0.0000353 Highly Informative Direct
Biological Process (BP) hormone transport 0.0000566 Highly Informative Direct
Biological Process (BP) phagocytosis 0.00008409 Highly Informative Direct
Biological Process (BP) detection of light stimulus 0.00014 Highly Informative Direct
Biological Process (BP) developmental growth 0.0001751 Highly Informative Direct
Biological Process (BP) inflammatory response 0.0001942 Highly Informative Direct
Biological Process (BP) positive regulation of cell division 0.0001985 Highly Informative Direct
Biological Process (BP) negative regulation of cell growth 0.0002002 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 0.000216 Highly Informative Direct
Biological Process (BP) positive regulation of intracellular transport 0.0002309 Highly Informative Direct
Biological Process (BP) protein localization to membrane 0.0002429 Highly Informative Direct
Biological Process (BP) negative regulation of protein catabolic process 0.0003575 Highly Informative Direct
Biological Process (BP) leukocyte migration 0.000426 Highly Informative Direct
Biological Process (BP) positive regulation of response to external stimulus 0.000526 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.0006352 Highly Informative Direct
Biological Process (BP) respiratory system development 0.0006462 Highly Informative Direct
Biological Process (BP) aminoglycan catabolic process 0.0006951 Highly Informative Direct
Biological Process (BP) female pregnancy 0.000719 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0.0008564 Highly Informative Direct
Biological Process (BP) muscle organ development 0.0009066 Highly Informative Direct
Biological Process (BP) angiogenesis 0.0009341 Highly Informative Direct
Biological Process (BP) regulation of organ morphogenesis 0.9291 Highly Informative Inherited
Biological Process (BP) negative regulation of endopeptidase activity 0.03203 Highly Informative Inherited
Biological Process (BP) cell adhesion 0.7433 Highly Informative Inherited
Biological Process (BP) extracellular matrix organization 1 Highly Informative Inherited
Biological Process (BP) response to drug 0.003902 Highly Informative Inherited
Biological Process (BP) cellular response to reactive oxygen species 0.1804 Highly Informative Inherited
Biological Process (BP) maintenance of location 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 1 Highly Informative Inherited
Biological Process (BP) response to carbohydrate 0.2044 Highly Informative Inherited
Biological Process (BP) cardiocyte differentiation 0.1258 Highly Informative Inherited
Biological Process (BP) retina development in camera-type eye 0.01318 Highly Informative Inherited
Biological Process (BP) protein tetramerization 0.595 Highly Informative Inherited
Biological Process (BP) sensory perception 1 Highly Informative Inherited
Biological Process (BP) positive regulation of neurogenesis 0.6752 Highly Informative Inherited
Biological Process (BP) regulation of endocytosis 0.2986 Highly Informative Inherited
Biological Process (BP) negative regulation of secretion by cell 0.06342 Highly Informative Inherited
Biological Process (BP) negative regulation of cytokine production 1 Highly Informative Inherited
Biological Process (BP) regulation of cytokine secretion 0.1271 Highly Informative Inherited
Biological Process (BP) negative regulation of protein transport 0.2705 Highly Informative Inherited
Biological Process (BP) glycosaminoglycan metabolic process 0.03881 Highly Informative Inherited
Biological Process (BP) signal release 1 Highly Informative Inherited
Biological Process (BP) multi-organism cellular process 0.7269 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.2096 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 0.006866 Highly Informative Inherited
Biological Process (BP) regulation of cell adhesion 0.001752 Highly Informative Inherited
Biological Process (BP) positive regulation of homeostatic process 0.009611 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cell activation 0.6932 Highly Informative Inherited
Biological Process (BP) regulation of nitric oxide biosynthetic process 0.001057 Highly Informative Inherited
Biological Process (BP) membrane fusion 1 Highly Informative Inherited
Biological Process (BP) regulation of protein serine/threonine kinase activity 1 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 1 Highly Informative Inherited
Biological Process (BP) regulation of cysteine-type endopeptidase activity involved in apoptotic process 0.2591 Highly Informative Inherited
Biological Process (BP) ensheathment of neurons 0.002186 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.5623 Highly Informative Inherited
Biological Process (BP) regulation of protein targeting 0.7443 Highly Informative Inherited
Biological Process (BP) cell projection morphogenesis 0.02197 Highly Informative Inherited
Biological Process (BP) response to purine-containing compound 0.008314 Highly Informative Inherited
Biological Process (BP) regulation of nucleocytoplasmic transport 0.07923 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular transport 0.02621 Highly Informative Inherited
Biological Process (BP) regulation of protein localization to nucleus 0.0729 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 1 Highly Informative Inherited
Biological Process (BP) limb morphogenesis 0.0492 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.001739 Highly Informative Inherited
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.6702 Highly Informative Inherited
Biological Process (BP) peptidyl-serine modification 0.002933 Highly Informative Inherited
Biological Process (BP) protein phosphorylation 1 Highly Informative Inherited
Biological Process (BP) mesenchyme development 0.03203 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.01285 Highly Informative Inherited
Biological Process (BP) neural tube development 0.5885 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 1 Highly Informative Inherited
Biological Process (BP) cell fate commitment 0.02735 Highly Informative Inherited
Biological Process (BP) ear development 0.9159 Highly Informative Inherited
Biological Process (BP) epidermis development 1 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.3424 Highly Informative Inherited
Biological Process (BP) post-embryonic development 1 Highly Informative Inherited
Biological Process (BP) germ cell development 1 Highly Informative Inherited
Biological Process (BP) columnar/cuboidal epithelial cell differentiation 1 Highly Informative Inherited
Biological Process (BP) epithelial cell development 1 Highly Informative Inherited
Biological Process (BP) protein import 0.05288 Highly Informative Inherited
Biological Process (BP) single-organism nuclear import 0.1054 Highly Informative Inherited
Biological Process (BP) protein targeting to nucleus 0.3828 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 1 Highly Informative Inherited
Biological Process (BP) connective tissue development 0.02599 Highly Informative Inherited
Biological Process (BP) cardiac muscle tissue development 0.1683 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 0.0134 Highly Informative Inherited
Biological Process (BP) exocytosis 0.9163 Highly Informative Inherited
Biological Process (BP) innate immune response 0.167 Highly Informative Inherited
Biological Process (BP) epithelial tube formation 1 Highly Informative Inherited
Biological Process (BP) carbohydrate homeostasis 0.05969 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) structural molecule activity 0.0000000000002188 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.00000001988 Moderately Informative Direct
Molecular Function (MF) small molecule binding 1 Moderately Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.08553 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.5009 Moderately Informative Inherited
Molecular Function (MF) cation binding 0.4722 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) receptor binding 0 Informative Direct
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) sulfur compound binding 0.000000000005329 Informative Direct
Molecular Function (MF) protein complex binding 0.00003247 Informative Direct
Molecular Function (MF) carboxylic acid binding 0.00004129 Informative Direct
Molecular Function (MF) tetrapyrrole binding 0.0001844 Informative Direct
Molecular Function (MF) peptidase regulator activity 0.0005734 Informative Direct
Molecular Function (MF) protein dimerization activity 0.8376 Informative Inherited
Molecular Function (MF) lipid binding 0.001536 Informative Inherited
Molecular Function (MF) molecular transducer activity 0.01427 Informative Inherited
Molecular Function (MF) enzyme activator activity 0.01988 Informative Inherited
Molecular Function (MF) peptidase activity 0.009426 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 0.7844 Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 0.001002 Informative Inherited
Molecular Function (MF) enzyme binding 1 Informative Inherited
Molecular Function (MF) calcium ion binding 0 Highly Informative Direct
Molecular Function (MF) cell adhesion molecule binding 0 Highly Informative Direct
Molecular Function (MF) glycolipid binding 0.00000000000001506 Highly Informative Direct
Molecular Function (MF) heparin binding 0.00000000000006482 Highly Informative Direct
Molecular Function (MF) serine hydrolase activity 0.000004515 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 0.00001734 Highly Informative Direct
Molecular Function (MF) endopeptidase activity 0.00008455 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0.00009096 Highly Informative Direct
Molecular Function (MF) heme binding 0.0001271 Highly Informative Direct
Molecular Function (MF) protein heterodimerization activity 0.0005471 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase inhibitor activity 0.0009404 Highly Informative Direct
Molecular Function (MF) amino acid binding 0.3391 Highly Informative Inherited
Molecular Function (MF) transmembrane signaling receptor activity 0.08997 Highly Informative Inherited
Molecular Function (MF) protein kinase regulator activity 0.24 Highly Informative Inherited
Molecular Function (MF) calcium ion transmembrane transporter activity 0.0464 Highly Informative Inherited
Molecular Function (MF) cation channel activity 0.507 Highly Informative Inherited
Molecular Function (MF) gated channel activity 0.5795 Highly Informative Inherited
Molecular Function (MF) growth factor receptor binding 0.001607 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on peroxide as acceptor 0.001065 Highly Informative Inherited
Molecular Function (MF) antioxidant activity 0.02072 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) protein complex 0.5765 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) plasma membrane part 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) intrinsic component of membrane 0.2877 Moderately Informative Inherited
Cellular Component (CC) membrane region 0.3526 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.008926 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) extracellular membrane-bounded organelle 0 Informative Direct
Cellular Component (CC) extracellular matrix 0 Informative Direct
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) side of membrane 0.00000000001327 Informative Direct
Cellular Component (CC) lipid particle 0.0000000001471 Informative Direct
Cellular Component (CC) cell leading edge 0.00000006556 Informative Direct
Cellular Component (CC) cell junction 0.000001893 Informative Direct
Cellular Component (CC) Golgi apparatus 0.0001859 Informative Direct
Cellular Component (CC) synapse 0.0002357 Informative Direct
Cellular Component (CC) endosome 0.0004972 Informative Direct
Cellular Component (CC) vacuolar part 0.004341 Informative Inherited
Cellular Component (CC) transporter complex 0.7025 Informative Inherited
Cellular Component (CC) secretory granule 0.0244 Informative Inherited
Cellular Component (CC) plasma membrane region 0.003173 Informative Inherited
Cellular Component (CC) integral component of membrane 0.2496 Informative Inherited
Cellular Component (CC) intrinsic component of plasma membrane 0.03163 Informative Inherited
Cellular Component (CC) lytic vacuole 0.003151 Informative Inherited
Cellular Component (CC) extracellular matrix part 0 Highly Informative Direct
Cellular Component (CC) proteinaceous extracellular matrix 0 Highly Informative Direct
Cellular Component (CC) receptor complex 0.00000000000002997 Highly Informative Direct
Cellular Component (CC) external side of plasma membrane 0.0000000001108 Highly Informative Direct
Cellular Component (CC) adherens junction 0.00000007048 Highly Informative Direct
Cellular Component (CC) sarcoplasmic reticulum 0.000005392 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.00002448 Highly Informative Direct
Cellular Component (CC) cell projection membrane 0.0009064 Highly Informative Direct
Cellular Component (CC) ion channel complex 1 Highly Informative Inherited
Cellular Component (CC) integral component of plasma membrane 0.1325 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

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EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases0.0002233Least InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Miscellaneous (requires further characterization)0InformativeDirect
Enzyme Commission (EC)Peroxidases0.000006591InformativeDirect
Enzyme Commission (EC)Coagulation factor IXa0.00000000002266Highly InformativeDirect
Enzyme Commission (EC)Complement subcomponent C1s0.0000000002421Highly InformativeDirect
Enzyme Commission (EC)Complement subcomponent C1r0.0000000002421Highly InformativeDirect
Enzyme Commission (EC)Protein C (activated)0.0000000146Highly InformativeDirect
Enzyme Commission (EC)Coagulation factor Xa0.00001257Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

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DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.3995Least InformativeInherited
Disease Ontology (DO)artery disease0.0217Moderately InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.05486Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.1517Moderately InformativeInherited
Disease Ontology (DO)skin disease0.6265Moderately InformativeInherited
Disease Ontology (DO)bullous pemphigoid0.0002353InformativeDirect
Disease Ontology (DO)atherosclerosis0.0004707InformativeDirect
Disease Ontology (DO)primary thrombocytopenia0.0004567Highly InformativeDirect
Disease Ontology (DO)vesiculobullous skin disease0.000537Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

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HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the globe0.04025Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0.09838Moderately InformativeInherited
Phenotypic Abnormality (PA)Generalized abnormality of skin0.3456Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the urinary system0.4904Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper respiratory tract0.005676InformativeInherited
Phenotypic Abnormality (PA)Localized skin lesion0.3489InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin morphology0.6815InformativeInherited
Phenotypic Abnormality (PA)Palmar hyperhidrosis0.000002908Highly InformativeDirect
Phenotypic Abnormality (PA)Milia0.0003796Highly InformativeDirect
Phenotypic Abnormality (PA)Laryngeal cyst0.0005155Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the anterior chamber0.0005429Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal blistering of the skin0.02553Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower urinary tract0.06309Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the nail0.2605Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

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MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.000000359Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0.1045Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.1301Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.2501Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.5683Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.5906Least InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.00009033Moderately InformativeDirect
Mammalian Phenotype (MP)muscle phenotype0.00009269Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal blood vessel morphology0.0001159Moderately InformativeDirect
Mammalian Phenotype (MP)renal/urinary system phenotype0.0001778Moderately InformativeDirect
Mammalian Phenotype (MP)integument phenotype0.002137Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.01075Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.01765Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.01876Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.02125Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.4315Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.5326Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell physiology0.6445Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.6726Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system physiology0.8941Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell-mediated immunity0.9792Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive immunity0.9897Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune cell physiology0.9946Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation0.00000264InformativeDirect
Mammalian Phenotype (MP)fibrosis0.00006176InformativeDirect
Mammalian Phenotype (MP)abnormal leukocyte migration0.0008992InformativeDirect
Mammalian Phenotype (MP)abnormal systemic artery morphology0.03307InformativeInherited
Mammalian Phenotype (MP)abnormal macrophage physiology0.116InformativeInherited
Mammalian Phenotype (MP)abnormal angiogenesis0.1271InformativeInherited
Mammalian Phenotype (MP)abnormal brain development0.2567InformativeInherited
Mammalian Phenotype (MP)abnormal female reproductive system physiology0.5084InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear sensory epithelium morphology0.52InformativeInherited
Mammalian Phenotype (MP)abnormal telencephalon morphology0.5298InformativeInherited
Mammalian Phenotype (MP)hemorrhage0.5405InformativeInherited
Mammalian Phenotype (MP)abnormal hair cell morphology0.6047InformativeInherited
Mammalian Phenotype (MP)abnormal membranous labyrinth morphology0.7467InformativeInherited
Mammalian Phenotype (MP)abnormal neuron number0.7698InformativeInherited
Mammalian Phenotype (MP)abnormal basement membrane morphology0.00000005074Highly InformativeDirect
Mammalian Phenotype (MP)dermal-epidermal separation0.00002161Highly InformativeDirect
Mammalian Phenotype (MP)abnormal aorta tunica media morphology0.0005114Highly InformativeDirect
Mammalian Phenotype (MP)skin hemorrhage0.0006141Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pregnancy0.0007564Highly InformativeDirect
Mammalian Phenotype (MP)decreased organ of Corti supporting cell number0.000966Highly InformativeDirect
Mammalian Phenotype (MP)abnormal sebaceous gland morphology0.00928Highly InformativeInherited
Mammalian Phenotype (MP)increased sensory neuron number0.009781Highly InformativeInherited
Mammalian Phenotype (MP)abnormal olfactory bulb development0.02024Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear hair cell number0.0614Highly InformativeInherited
Mammalian Phenotype (MP)abnormal dorsal root ganglion morphology0.3494Highly InformativeInherited
Mammalian Phenotype (MP)abnormal vein morphology0.3802Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear inner hair cell morphology0.9388Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

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WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.09377Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.5332Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.7574Least InformativeInherited
Worm Phenotype (WP)organ system development variant0.000000001406Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.00004904Moderately InformativeDirect
Worm Phenotype (WP)locomotion variant0.0004116Moderately InformativeDirect
Worm Phenotype (WP)larval lethal0.002104Moderately InformativeInherited
Worm Phenotype (WP)cell death variant0.1289Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.2636Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.5176Moderately InformativeInherited
Worm Phenotype (WP)gametogenesis variant0.6654Moderately InformativeInherited
Worm Phenotype (WP)muscle cell morphology variant0.000009269InformativeDirect
Worm Phenotype (WP)body length variant0.0001052InformativeDirect
Worm Phenotype (WP)anchor cell invasion variant0.0002273InformativeDirect
Worm Phenotype (WP)somatic gonad development variant0.0003895InformativeDirect
Worm Phenotype (WP)activity level variant0.0005193InformativeDirect
Worm Phenotype (WP)body wall muscle morphology variant0.001095InformativeInherited
Worm Phenotype (WP)protein metabolism variant0.001646InformativeInherited
Worm Phenotype (WP)VPC competence variant0.003412InformativeInherited
Worm Phenotype (WP)cell corpse number variant0.005543InformativeInherited
Worm Phenotype (WP)chemotaxis variant0.01059InformativeInherited
Worm Phenotype (WP)vulva development variant0.01957InformativeInherited
Worm Phenotype (WP)locomotor coordination variant0.06792InformativeInherited
Worm Phenotype (WP)copulation variant0.06917InformativeInherited
Worm Phenotype (WP)protein expression variant0.07409InformativeInherited
Worm Phenotype (WP)neuron development variant0.3556InformativeInherited
Worm Phenotype (WP)male behavior variant1InformativeInherited
Worm Phenotype (WP)muscle arm development defective0.000003587Highly InformativeDirect
Worm Phenotype (WP)protein degradation variant0.0002093Highly InformativeDirect
Worm Phenotype (WP)roller0.0002282Highly InformativeDirect
Worm Phenotype (WP)developmental morphology variant0.0003415Highly InformativeDirect
Worm Phenotype (WP)accumulated germline cell corpses0.0004667Highly InformativeDirect
Worm Phenotype (WP)loss of asymmetry ASE0.000484Highly InformativeDirect
Worm Phenotype (WP)negative chemotaxis variant0.0006188Highly InformativeDirect
Worm Phenotype (WP)male mating defective0.0006954Highly InformativeDirect
Worm Phenotype (WP)axon guidance variant0.0007544Highly InformativeDirect
Worm Phenotype (WP)germline proliferation variant0.01557Highly InformativeInherited
Worm Phenotype (WP)alimentary system morphology variant0.01712Highly InformativeInherited
Worm Phenotype (WP)level of protein expression variant0.01733Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

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FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0.605Least InformativeInherited
Fly Phenotype (FP)lethal - all die before end of P-stage0.0004759Moderately InformativeDirect
Fly Phenotype (FP)lethal - all die before end of larval stage0.00001158InformativeDirect
Fly Phenotype (FP)lethal - all die before end of embryonic stage0.00000006919Highly InformativeDirect
Fly Phenotype (FP)some die during embryonic stage0.0000005362Highly InformativeDirect
Fly Phenotype (FP)planar polarity defective0.0008696Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

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