SUPERFAMILY 1.75 HMM library and genome assignments server


Growth factor receptor domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Knottins (small inhibitors, toxins, lectins) [ 57015] (19)
Superfamily:   Growth factor receptor domain [ 57184]
Families:   Growth factor receptor domain [ 57185] (8)


Superfamily statistics
Genomes (347) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 38,065 0 28
Proteins 17,971 0 21


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)developmental process1.163e-060Least InformativeDirect
Biological Process (BP)multicellular organismal process3.049e-060Least InformativeDirect
Biological Process (BP)localization0.0025366.012e-14Least InformativeInherited
Biological Process (BP)single-organism cellular process0.050090Least InformativeInherited
Biological Process (BP)regulation of cellular process0.0057090.04675Least InformativeInherited
Biological Process (BP)response to stimulus0.011730Least InformativeInherited
Biological Process (BP)single-organism developmental process3.258e-070Moderately InformativeDirect
Biological Process (BP)signal transduction0.00017830Moderately InformativeDirect
Biological Process (BP)enzyme linked receptor protein signaling pathway4.149e-080InformativeDirect
Biological Process (BP)localization of cell3.648e-070InformativeDirect
Biological Process (BP)locomotion1.508e-060InformativeDirect
Biological Process (BP)cellular component movement9.332e-050InformativeDirect
Biological Process (BP)transmembrane receptor protein tyrosine kinase signaling pathway1.132e-082.155e-05Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) localization 6.012e-14 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.04675 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.002105 Least Informative Inherited
Biological Process (BP) single-organism developmental process 0 Moderately Informative Direct
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) nervous system development 9.343e-06 Moderately Informative Direct
Biological Process (BP) organ development 0.0007563 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 3.171e-11 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 7.281e-15 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 1.077e-14 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 3.068e-11 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 1.92e-09 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 3.183e-09 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 3.026e-07 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 4.477e-06 Moderately Informative Direct
Biological Process (BP) immune system process 0.0001146 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.0003965 Moderately Informative Direct
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.03375 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.8754 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.1072 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.3238 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.01316 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.1782 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.04531 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.6451 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.006415 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.566 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.3539 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.6087 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.2934 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.3225 Moderately Informative Inherited
Biological Process (BP) reproduction 0.01172 Moderately Informative Inherited
Biological Process (BP) tissue development 0.006378 Moderately Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0 Informative Direct
Biological Process (BP) localization of cell 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) cellular component movement 0 Informative Direct
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) biological adhesion 0 Informative Direct
Biological Process (BP) cell projection organization 0 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0 Informative Direct
Biological Process (BP) response to wounding 3.095e-14 Informative Direct
Biological Process (BP) regulation of cell proliferation 1.505e-13 Informative Direct
Biological Process (BP) regulation of apoptotic process 3.486e-11 Informative Direct
Biological Process (BP) negative regulation of developmental process 7.951e-11 Informative Direct
Biological Process (BP) cellular component morphogenesis 1.598e-09 Informative Direct
Biological Process (BP) growth 1.68e-09 Informative Direct
Biological Process (BP) positive regulation of developmental process 2.332e-09 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 4.593e-09 Informative Direct
Biological Process (BP) vesicle-mediated transport 1.064e-07 Informative Direct
Biological Process (BP) cardiovascular system development 3.83e-07 Informative Direct
Biological Process (BP) programmed cell death 7.616e-07 Informative Direct
Biological Process (BP) regulation of protein phosphorylation 1.193e-06 Informative Direct
Biological Process (BP) organ morphogenesis 3.099e-06 Informative Direct
Biological Process (BP) central nervous system development 3.255e-06 Informative Direct
Biological Process (BP) tube development 1.651e-05 Informative Direct
Biological Process (BP) tissue morphogenesis 2.022e-05 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 3.571e-05 Informative Direct
Biological Process (BP) negative regulation of signaling 6.94e-05 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0.0001452 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.0001642 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.0003795 Informative Direct
Biological Process (BP) generation of neurons 0.0004797 Informative Direct
Biological Process (BP) response to nutrient levels 0.0005517 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.0007043 Informative Direct
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.2581 Informative Inherited
Biological Process (BP) cellular membrane organization 0.08119 Informative Inherited
Biological Process (BP) protein transport 0.002327 Informative Inherited
Biological Process (BP) muscle structure development 0.6411 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.07738 Informative Inherited
Biological Process (BP) regulation of growth 0.002672 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.2663 Informative Inherited
Biological Process (BP) protein complex assembly 0.002599 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 0.007066 Informative Inherited
Biological Process (BP) transmission of nerve impulse 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.1476 Informative Inherited
Biological Process (BP) regulation of secretion 0.135 Informative Inherited
Biological Process (BP) sensory organ development 0.018 Informative Inherited
Biological Process (BP) embryonic organ development 0.04994 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.142 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) secretion by cell 0.02307 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.002826 Informative Inherited
Biological Process (BP) positive regulation of transport 0.4521 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.06803 Informative Inherited
Biological Process (BP) regulation of response to stress 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.8033 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of gene expression 0.4943 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.86 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.01978 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.6642 Informative Inherited
Biological Process (BP) cell-cell signaling 0.3156 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.001737 Informative Inherited
Biological Process (BP) regulation of locomotion 0.001855 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.8344 Informative Inherited
Biological Process (BP) protein catabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.9226 Informative Inherited
Biological Process (BP) response to cytokine stimulus 0.3589 Informative Inherited
Biological Process (BP) defense response 0.03968 Informative Inherited
Biological Process (BP) immune response 0.6654 Informative Inherited
Biological Process (BP) immune effector process 0.7141 Informative Inherited
Biological Process (BP) secondary metabolic process 0.0779 Informative Inherited
Biological Process (BP) regulation of nucleoside metabolic process 0.001207 Informative Inherited
Biological Process (BP) regulation of purine nucleotide metabolic process 0.001297 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.6871 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.5735 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.6795 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 1 Informative Inherited
Biological Process (BP) regulation of cytokine production 1 Informative Inherited
Biological Process (BP) response to lipid 0.4069 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.6807 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.05152 Informative Inherited
Biological Process (BP) positive regulation of protein modification process 0.1167 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.2142 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.1626 Informative Inherited
Biological Process (BP) gland development 0.001228 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.5749 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.2399 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.1317 Informative Inherited
Biological Process (BP) lipid localization 0.3919 Informative Inherited
Biological Process (BP) regulation of cell development 0.8642 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) regulation of peptidase activity 0.002964 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.2215 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.4143 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) cytoplasmic transport 1 Informative Inherited
Biological Process (BP) protein localization to organelle 1 Informative Inherited
Biological Process (BP) pigment metabolic process 0.001447 Informative Inherited
Biological Process (BP) muscle tissue development 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.009887 Informative Inherited
Biological Process (BP) blood circulation 1 Informative Inherited
Biological Process (BP) epithelium development 0.3233 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.006051 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.229 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.6384 Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 2.155e-05 Highly Informative Direct
Biological Process (BP) protein phosphorylation 0 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0 Highly Informative Direct
Biological Process (BP) chemotaxis 0 Highly Informative Direct
Biological Process (BP) peptidyl-tyrosine modification 0 Highly Informative Direct
Biological Process (BP) cell adhesion 0 Highly Informative Direct
Biological Process (BP) regulation of Rho GTPase activity 1.015e-10 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 8.154e-09 Highly Informative Direct
Biological Process (BP) regulation of protein localization to nucleus 2.681e-08 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 2.767e-08 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 9.835e-08 Highly Informative Direct
Biological Process (BP) negative regulation of sequence-specific DNA binding transcription factor activity 2.303e-07 Highly Informative Direct
Biological Process (BP) positive regulation of intracellular transport 2.44e-07 Highly Informative Direct
Biological Process (BP) negative regulation of secretion 4.891e-07 Highly Informative Direct
Biological Process (BP) cell projection morphogenesis 5.021e-07 Highly Informative Direct
Biological Process (BP) regulation of cell size 7.902e-07 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 9.416e-07 Highly Informative Direct
Biological Process (BP) plasma membrane organization 2.002e-06 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 4.801e-06 Highly Informative Direct
Biological Process (BP) regulation of cell growth 5.195e-06 Highly Informative Direct
Biological Process (BP) regulation of ERK1 and ERK2 cascade 6.351e-06 Highly Informative Direct
Biological Process (BP) regulation of nucleocytoplasmic transport 6.42e-06 Highly Informative Direct
Biological Process (BP) regulation of intracellular protein transport 7.082e-06 Highly Informative Direct
Biological Process (BP) positive regulation of cell differentiation 7.239e-06 Highly Informative Direct
Biological Process (BP) phagocytosis 1.127e-05 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 1.522e-05 Highly Informative Direct
Biological Process (BP) hormone transport 1.592e-05 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 2.505e-05 Highly Informative Direct
Biological Process (BP) regulation of cytokine secretion 2.55e-05 Highly Informative Direct
Biological Process (BP) respiratory system development 3.608e-05 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular transport 3.82e-05 Highly Informative Direct
Biological Process (BP) telencephalon development 7.567e-05 Highly Informative Direct
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 8.111e-05 Highly Informative Direct
Biological Process (BP) organic hydroxy compound transport 0.0001028 Highly Informative Direct
Biological Process (BP) regulation of protein kinase B signaling cascade 0.0001317 Highly Informative Direct
Biological Process (BP) angiogenesis 0.0001719 Highly Informative Direct
Biological Process (BP) regulation of mononuclear cell proliferation 0.0001776 Highly Informative Direct
Biological Process (BP) inner ear development 0.0002074 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0.0002114 Highly Informative Direct
Biological Process (BP) sterol metabolic process 0.0002116 Highly Informative Direct
Biological Process (BP) regulation of striated muscle tissue development 0.0002875 Highly Informative Direct
Biological Process (BP) pattern specification process 0.0004309 Highly Informative Direct
Biological Process (BP) cell fate commitment 0.000441 Highly Informative Direct
Biological Process (BP) glial cell differentiation 0.0004943 Highly Informative Direct
Biological Process (BP) multi-organism cellular process 0.0006351 Highly Informative Direct
Biological Process (BP) regulation of actin cytoskeleton organization 0.0007737 Highly Informative Direct
Biological Process (BP) positive regulation of peptidyl-tyrosine phosphorylation 0.0008632 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0.0009804 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.01731 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic process 0.2019 Highly Informative Inherited
Biological Process (BP) stem cell development 0.2921 Highly Informative Inherited
Biological Process (BP) negative regulation of locomotion 0.008631 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular component movement 0.01454 Highly Informative Inherited
Biological Process (BP) regulation of angiogenesis 0.1441 Highly Informative Inherited
Biological Process (BP) muscle fiber development 0.001161 Highly Informative Inherited
Biological Process (BP) response to carbohydrate stimulus 0.008258 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 0.01479 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in neuron differentiation 0.003009 Highly Informative Inherited
Biological Process (BP) developmental growth 0.007194 Highly Informative Inherited
Biological Process (BP) mammary gland epithelium development 0.002277 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.04659 Highly Informative Inherited
Biological Process (BP) protein tetramerization 0.001278 Highly Informative Inherited
Biological Process (BP) regulation of binding 0.6868 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.1645 Highly Informative Inherited
Biological Process (BP) regulation of endocytosis 0.03118 Highly Informative Inherited
Biological Process (BP) post-embryonic development 1 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.4362 Highly Informative Inherited
Biological Process (BP) negative regulation of growth 0.08975 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.1753 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.7915 Highly Informative Inherited
Biological Process (BP) leukocyte migration 0.002285 Highly Informative Inherited
Biological Process (BP) regulation of synaptic transmission 0.002406 Highly Informative Inherited
Biological Process (BP) signal release 0.714 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.3661 Highly Informative Inherited
Biological Process (BP) positive regulation of transcription, DNA-dependent 1 Highly Informative Inherited
Biological Process (BP) regulation of mitosis 0.0419 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 0.07719 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.1049 Highly Informative Inherited
Biological Process (BP) regulation of cysteine-type endopeptidase activity 0.04646 Highly Informative Inherited
Biological Process (BP) negative regulation of endopeptidase activity 0.009518 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 1 Highly Informative Inherited
Biological Process (BP) wound healing 0.02218 Highly Informative Inherited
Biological Process (BP) regulation of protein catabolic process 0.4436 Highly Informative Inherited
Biological Process (BP) lipoprotein metabolic process 0.001021 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 1 Highly Informative Inherited
Biological Process (BP) positive regulation of leukocyte proliferation 0.9234 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.3035 Highly Informative Inherited
Biological Process (BP) innate immune response 0.1184 Highly Informative Inherited
Biological Process (BP) negative regulation of protein transport 0.002022 Highly Informative Inherited
Biological Process (BP) response to peptide hormone stimulus 0.01484 Highly Informative Inherited
Biological Process (BP) cellular response to peptide 0.03279 Highly Informative Inherited
Biological Process (BP) positive regulation of Ras GTPase activity 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cell activation 0.001678 Highly Informative Inherited
Biological Process (BP) protein processing 0.001245 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.02011 Highly Informative Inherited
Biological Process (BP) epidermal cell differentiation 0.5125 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.9588 Highly Informative Inherited
Biological Process (BP) axon development 0.04398 Highly Informative Inherited
Biological Process (BP) nuclear import 0.01222 Highly Informative Inherited
Biological Process (BP) protein import 0.02047 Highly Informative Inherited
Biological Process (BP) protein localization to nucleus 0.02971 Highly Informative Inherited
Biological Process (BP) protein targeting to nucleus 0.3426 Highly Informative Inherited
Biological Process (BP) cardiac muscle tissue development 1 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.3126 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 0.3497 Highly Informative Inherited
Biological Process (BP) regulation of blood pressure 0.001452 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 1.343e-05 Moderately Informative Direct
Molecular Function (MF) anion binding 0.163 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) cation binding 1 Moderately Informative Inherited
Molecular Function (MF) structural molecule activity 0.007717 Moderately Informative Inherited
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) receptor binding 0 Informative Direct
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) sulfur compound binding 7.425e-12 Informative Direct
Molecular Function (MF) carbohydrate derivative binding 9.99e-11 Informative Direct
Molecular Function (MF) peptidase regulator activity 4.722e-07 Informative Direct
Molecular Function (MF) enzyme inhibitor activity 1.802e-05 Informative Direct
Molecular Function (MF) enzyme activator activity 6.174e-05 Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 0.1666 Informative Inherited
Molecular Function (MF) carboxylic acid binding 0.002451 Informative Inherited
Molecular Function (MF) amide binding 0.02153 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 0.0246 Informative Inherited
Molecular Function (MF) peptidase activity 0.03595 Informative Inherited
Molecular Function (MF) lipid binding 0.4195 Informative Inherited
Molecular Function (MF) enzyme binding 0.8628 Informative Inherited
Molecular Function (MF) protein kinase activity 0 Highly Informative Direct
Molecular Function (MF) heparin binding 2.271e-11 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 3.218e-11 Highly Informative Direct
Molecular Function (MF) protein kinase regulator activity 1.253e-09 Highly Informative Direct
Molecular Function (MF) calcium ion binding 6.493e-09 Highly Informative Direct
Molecular Function (MF) hormone binding 1.819e-05 Highly Informative Direct
Molecular Function (MF) calcium ion transmembrane transporter activity 1.939e-05 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase inhibitor activity 3.409e-05 Highly Informative Direct
Molecular Function (MF) peptide binding 0.0001183 Highly Informative Direct
Molecular Function (MF) protein complex binding 0.0006112 Highly Informative Direct
Molecular Function (MF) phosphatase regulator activity 0.01279 Highly Informative Inherited
Molecular Function (MF) amino acid binding 0.002389 Highly Informative Inherited
Molecular Function (MF) cation channel activity 0.005149 Highly Informative Inherited
Molecular Function (MF) ion gated channel activity 0.007359 Highly Informative Inherited
Molecular Function (MF) growth factor receptor binding 0.3952 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) cell projection 6.255e-09 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.06498 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 0.03257 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) endosome 0 Informative Direct
Cellular Component (CC) extracellular matrix 0 Informative Direct
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 4.461e-12 Informative Direct
Cellular Component (CC) Golgi apparatus 4.219e-07 Informative Direct
Cellular Component (CC) lytic vacuole 8.492e-05 Informative Direct
Cellular Component (CC) cell leading edge 0.000379 Informative Direct
Cellular Component (CC) neuron projection 0.9725 Informative Inherited
Cellular Component (CC) intrinsic to plasma membrane 0.09614 Informative Inherited
Cellular Component (CC) integral to membrane 0.945 Informative Inherited
Cellular Component (CC) proteinaceous extracellular matrix 0 Highly Informative Direct
Cellular Component (CC) extracellular matrix part 0 Highly Informative Direct
Cellular Component (CC) receptor complex 5.387e-08 Highly Informative Direct
Cellular Component (CC) endosomal part 2.853e-07 Highly Informative Direct
Cellular Component (CC) lysosome 9.478e-06 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 1.577e-05 Highly Informative Direct
Cellular Component (CC) dendrite 0.0001587 Highly Informative Direct
Cellular Component (CC) cell body 0.0004712 Highly Informative Direct
Cellular Component (CC) integral to plasma membrane 0.000658 Highly Informative Direct
Cellular Component (CC) membrane raft 0.002874 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

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EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)8.291e-07Least InformativeDirect
Enzyme Commission (EC)Serine endopeptidases6.22e-06Moderately InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Furin0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

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DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.1112Least InformativeInherited
Disease Ontology (DO)immune system disease0.6236Least InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.01333Moderately InformativeInherited
Disease Ontology (DO)cell type cancer0.01462Moderately InformativeInherited
Disease Ontology (DO)benign neoplasm0.08349Moderately InformativeInherited
Disease Ontology (DO)nervous system cancer0.09938Moderately InformativeInherited
Disease Ontology (DO)malignant glioma0.0001159InformativeDirect
Disease Ontology (DO)colorectal cancer0.0004264InformativeDirect
Disease Ontology (DO)liver carcinoma0.0009114InformativeDirect
Disease Ontology (DO)organ system benign neoplasm0.06889InformativeInherited
Disease Ontology (DO)peripheral nervous system neoplasm0.4555InformativeInherited
Disease Ontology (DO)primary thrombocytopenia9.043e-06Highly InformativeDirect
Disease Ontology (DO)skin hemangioma9.688e-06Highly InformativeDirect
Disease Ontology (DO)neurofibroma1.538e-05Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

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HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.1714Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digit0.001798Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hand0.01228Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.04314Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the systemic arterial tree0.3063InformativeInherited
Phenotypic Abnormality (PA)Arachnodactyly0.0004153Highly InformativeDirect
Phenotypic Abnormality (PA)Dilatation of the ascending aorta0.0006612Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

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MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype2.451e-06Least InformativeDirect
Mammalian Phenotype (MP)nervous system phenotype0.1134Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.1311Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.3788Least InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology9.314e-07Moderately InformativeDirect
Mammalian Phenotype (MP)renal/urinary system phenotype4.553e-06Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal nervous system development0.0001459Moderately InformativeDirect
Mammalian Phenotype (MP)muscle phenotype0.0002577Moderately InformativeDirect
Mammalian Phenotype (MP)respiratory system phenotype0.002367Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.006887Moderately InformativeInherited
Mammalian Phenotype (MP)digestive/alimentary phenotype0.0169Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.061Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.06802Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.07077Moderately InformativeInherited
Mammalian Phenotype (MP)preweaning lethality0.08433Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.1795Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.4722Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.5552Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.6394Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.8001Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lung morphology1.211e-06InformativeDirect
Mammalian Phenotype (MP)abnormal cranium morphology1.915e-05InformativeDirect
Mammalian Phenotype (MP)abnormal membranous labyrinth morphology0.0008048InformativeDirect
Mammalian Phenotype (MP)abnormal systemic artery morphology0.02InformativeInherited
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.02686InformativeInherited
Mammalian Phenotype (MP)abnormal neuron number0.1147InformativeInherited
Mammalian Phenotype (MP)abnormal skeletal muscle morphology0.1914InformativeInherited
Mammalian Phenotype (MP)abnormal angiogenesis0.2345InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear sensory epithelium morphology0.3205InformativeInherited
Mammalian Phenotype (MP)abnormal brain development0.3946InformativeInherited
Mammalian Phenotype (MP)abnormal hair cell morphology0.4714InformativeInherited
Mammalian Phenotype (MP)abnormal kidney physiology0.5199InformativeInherited
Mammalian Phenotype (MP)decreased cell proliferation0.5779InformativeInherited
Mammalian Phenotype (MP)abnormal intestine morphology0.7495InformativeInherited
Mammalian Phenotype (MP)abnormal aorta tunica media morphology2.792e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cardinal vein morphology0.0001034Highly InformativeDirect
Mammalian Phenotype (MP)decreased organ of Corti supporting cell number0.0002179Highly InformativeDirect
Mammalian Phenotype (MP)aneurysm0.0004083Highly InformativeDirect
Mammalian Phenotype (MP)perinatal lethality0.0005356Highly InformativeDirect
Mammalian Phenotype (MP)absent sebaceous gland0.000627Highly InformativeDirect
Mammalian Phenotype (MP)small kidney0.0006541Highly InformativeDirect
Mammalian Phenotype (MP)abnormal olfactory bulb development0.01947Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear hair cell number0.05822Highly InformativeInherited
Mammalian Phenotype (MP)increased sensory neuron number0.0769Highly InformativeInherited
Mammalian Phenotype (MP)abnormal respiratory system development0.08215Highly InformativeInherited
Mammalian Phenotype (MP)abnormal ureteric bud morphology0.08883Highly InformativeInherited
Mammalian Phenotype (MP)abnormal diaphragm morphology0.5075Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear inner hair cell morphology0.7257Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

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WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)larval development variant0.4669Least InformativeInherited
Worm Phenotype (WP)organ system development variant3.679e-06Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant1.627e-05Moderately InformativeDirect
Worm Phenotype (WP)locomotion variant0.0006497Moderately InformativeDirect
Worm Phenotype (WP)larval lethal0.2271Moderately InformativeInherited
Worm Phenotype (WP)male morphology variant3.331e-05InformativeDirect
Worm Phenotype (WP)muscle cell morphology variant4.042e-05InformativeDirect
Worm Phenotype (WP)egg laying variant0.0001402InformativeDirect
Worm Phenotype (WP)body length variant0.0002221InformativeDirect
Worm Phenotype (WP)body width variant0.0003162InformativeDirect
Worm Phenotype (WP)activity level variant0.01925InformativeInherited
Worm Phenotype (WP)neuron development variant0.02399InformativeInherited
Worm Phenotype (WP)molt variant1.729e-07Highly InformativeDirect
Worm Phenotype (WP)myopodia present3.625e-07Highly InformativeDirect
Worm Phenotype (WP)loss of asymmetry ASE4.27e-06Highly InformativeDirect
Worm Phenotype (WP)paralyzed1.734e-05Highly InformativeDirect
Worm Phenotype (WP)muscle arm development defective2.228e-05Highly InformativeDirect
Worm Phenotype (WP)axon guidance variant5.658e-05Highly InformativeDirect
Worm Phenotype (WP)dauer arrest variant0.0005952Highly InformativeDirect
Worm Phenotype (WP)muscle system development variant0.005357Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

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FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)size defective8.601e-05InformativeDirect
Fly Phenotype (FP)cell polarity defective0.0001433InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

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FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system subdivision0.1059Least InformativeInherited
Fly Anatomy (FA)larva0.1992Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.2069Least InformativeInherited
Fly Anatomy (FA)organ system0.2197Least InformativeInherited
Fly Anatomy (FA)anatomical group0.4136Least InformativeInherited
Fly Anatomy (FA)cell0.999Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.01476Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.0645Moderately InformativeInherited
Fly Anatomy (FA)portion of tissue0.0669Moderately InformativeInherited
Fly Anatomy (FA)neuron0.1167Moderately InformativeInherited
Fly Anatomy (FA)adult nervous system0.1379Moderately InformativeInherited
Fly Anatomy (FA)cell cluster organ0.1474Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.1568Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.208Moderately InformativeInherited
Fly Anatomy (FA)sense organ0.2739Moderately InformativeInherited
Fly Anatomy (FA)head0.3793Moderately InformativeInherited
Fly Anatomy (FA)reproductive system0.388Moderately InformativeInherited
Fly Anatomy (FA)developing material anatomical entity0.5262Moderately InformativeInherited
Fly Anatomy (FA)integumentary specialisation0.0003824InformativeDirect
Fly Anatomy (FA)chemosensory system0.0008213InformativeDirect
Fly Anatomy (FA)tract neuropil0.0009727InformativeDirect
Fly Anatomy (FA)neuron projection bundle0.0009843InformativeDirect
Fly Anatomy (FA)tracheal system0.002286InformativeInherited
Fly Anatomy (FA)protocerebrum0.006478InformativeInherited
Fly Anatomy (FA)alimentary canal0.007782InformativeInherited
Fly Anatomy (FA)primordium0.01306InformativeInherited
Fly Anatomy (FA)embryonic/larval nervous system0.01678InformativeInherited
Fly Anatomy (FA)larval segment0.02096InformativeInherited
Fly Anatomy (FA)eye photoreceptor cell0.03857InformativeInherited
Fly Anatomy (FA)interneuron0.04164InformativeInherited
Fly Anatomy (FA)circulatory system0.04974InformativeInherited
Fly Anatomy (FA)testis0.07187InformativeInherited
Fly Anatomy (FA)extended germ band embryo0.1107InformativeInherited
Fly Anatomy (FA)presumptive embryonic/larval digestive system0.1237InformativeInherited
Fly Anatomy (FA)dorsal closure embryo0.1343InformativeInherited
Fly Anatomy (FA)synaptic neuropil domain0.1806InformativeInherited
Fly Anatomy (FA)pupa0.1808InformativeInherited
Fly Anatomy (FA)somatic stem cell0.643InformativeInherited
Fly Anatomy (FA)ventral nervous system7.872e-06Highly InformativeDirect
Fly Anatomy (FA)hub cell6.218e-05Highly InformativeDirect
Fly Anatomy (FA)adult heart0.0001439Highly InformativeDirect
Fly Anatomy (FA)photoreceptor cell R70.0004992Highly InformativeDirect
Fly Anatomy (FA)peptidergic neuron0.001952Highly InformativeInherited
Fly Anatomy (FA)neuroblast of ventral nerve cord primordium0.002585Highly InformativeInherited
Fly Anatomy (FA)embryonic/larval neuron0.007813Highly InformativeInherited
Fly Anatomy (FA)hindgut0.00953Highly InformativeInherited
Fly Anatomy (FA)larval procephalic segment0.01453Highly InformativeInherited
Fly Anatomy (FA)embryonic/larval brain0.02694Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

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ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)portion of tissue0.08556Least InformativeInherited
Zebrafish Anatomy (ZA)multi-tissue structure0.1539Least InformativeInherited
Zebrafish Anatomy (ZA)trunk0.3545Least InformativeInherited
Zebrafish Anatomy (ZA)head0.7279Least InformativeInherited
Zebrafish Anatomy (ZA)suspensorium0.3022Moderately InformativeInherited
Zebrafish Anatomy (ZA)pharyngeal arch0.7687Moderately InformativeInherited
Zebrafish Anatomy (ZA)symplectic0.0003332InformativeDirect
Zebrafish Anatomy (ZA)somite 20.0004209InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

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XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)central nervous system0.2135Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.4286Least InformativeInherited
Xenopus ANatomical entity (XAN)portion of tissue0.4557Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.7734Least InformativeInherited
Xenopus ANatomical entity (XAN)cell1Least InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.01137Moderately InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.1302Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.3382Moderately InformativeInherited
Xenopus ANatomical entity (XAN)surface structure0.9578Moderately InformativeInherited
Xenopus ANatomical entity (XAN)visual system1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)mesoderm1.537e-05InformativeDirect
Xenopus ANatomical entity (XAN)mesenchyme4.946e-05InformativeDirect
Xenopus ANatomical entity (XAN)pharyngeal region9.806e-05InformativeDirect
Xenopus ANatomical entity (XAN)endoderm0.0002969InformativeDirect
Xenopus ANatomical entity (XAN)neural plate0.0003503InformativeDirect
Xenopus ANatomical entity (XAN)spinal cord0.002986InformativeInherited
Xenopus ANatomical entity (XAN)tail0.5911InformativeInherited
Xenopus ANatomical entity (XAN)hypochord1.643e-05Highly InformativeDirect
Xenopus ANatomical entity (XAN)optic vesicle0.0004269Highly InformativeDirect
Xenopus ANatomical entity (XAN)chordoneural hinge0.0004292Highly InformativeDirect
Xenopus ANatomical entity (XAN)floor plate0.0006584Highly InformativeDirect
Xenopus ANatomical entity (XAN)zygote0.001118Highly InformativeInherited
Xenopus ANatomical entity (XAN)neural plate border0.01584Highly InformativeInherited
Xenopus DEvelopment stage (XDE)embryonic stage6.38e-05Least InformativeDirect
Xenopus DEvelopment stage (XDE)NF stage0.0001534Least InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

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EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)3.155e-06Moderately InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Serine endopeptidases5.746e-07InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

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KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processDifferentiation0Moderately InformativeDirect
Biological processApoptosis8.397e-07Moderately InformativeDirect
Biological processLipid metabolism0.49Moderately InformativeInherited
Biological processAngiogenesis0InformativeDirect
Biological processCell adhesion0InformativeDirect
Biological processEndocytosis0InformativeDirect
Biological processHemostasis0InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processWnt signaling pathway0InformativeDirect
Biological processSensory transduction4.907e-14InformativeDirect
Biological processSteroid metabolism1.158e-13InformativeDirect
Biological processLipid transport7.163e-11InformativeDirect
Biological processInnate immunity1.35e-06InformativeDirect
Biological processCytolysis1.074e-05InformativeDirect
Biological processBlood coagulation0Highly InformativeDirect
Biological processCholesterol metabolism0Highly InformativeDirect
Biological processGrowth regulation0Highly InformativeDirect
Biological processNotch signaling pathway0Highly InformativeDirect
Biological processComplement alternate pathway2.606e-07Highly InformativeDirect
Biological processDNA synthesis3.466e-06Highly InformativeDirect
Biological processComplement pathway9.506e-05Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentEndosome8.852e-14Moderately InformativeDirect
Cellular componentGolgi apparatus9.404e-05Moderately InformativeDirect
Cellular componentExtracellular matrix0InformativeDirect
Cellular componentLysosome3.771e-06InformativeDirect
Cellular componentCoated pit0Highly InformativeDirect
Coding sequence diversityPolymorphism1.188e-05Moderately InformativeDirect
DiseaseDisease mutation1.498e-06Least InformativeDirect
DiseaseDwarfism0.000898Highly InformativeDirect
DomainRepeat0Least Infor