SUPERFAMILY 1.75 HMM library and genome assignments server


Growth factor receptor domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Knottins (small inhibitors, toxins, lectins) [ 57015] (19)
Superfamily:   Growth factor receptor domain [ 57184]
Families:   Growth factor receptor domain [ 57185] (8)


Superfamily statistics
Genomes (318) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 36,955 35,099 28
Proteins 17,287 16,797 21


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)developmental process1.307e-060Least InformativeDirect
Biological Process (BP)multicellular organismal process3.403e-060Least InformativeDirect
Biological Process (BP)localization0.0027033.443e-14Least InformativeInherited
Biological Process (BP)single-organism cellular process0.048740Least InformativeInherited
Biological Process (BP)regulation of cellular process0.0060770.02638Least InformativeInherited
Biological Process (BP)response to stimulus0.01240Least InformativeInherited
Biological Process (BP)single-organism developmental process3.722e-070Moderately InformativeDirect
Biological Process (BP)signal transduction0.00020Moderately InformativeDirect
Biological Process (BP)enzyme linked receptor protein signaling pathway4.895e-080InformativeDirect
Biological Process (BP)localization of cell3.714e-070InformativeDirect
Biological Process (BP)locomotion1.475e-060InformativeDirect
Biological Process (BP)cellular component movement8.465e-050InformativeDirect
Biological Process (BP)transmembrane receptor protein tyrosine kinase signaling pathway1.373e-083.083e-05Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) localization 3.443e-14 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.02638 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.002556 Least Informative Inherited
Biological Process (BP) single-organism developmental process 0 Moderately Informative Direct
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) nervous system development 1.529e-07 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 2.54e-09 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 2.78e-14 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 7.006e-14 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 1.867e-11 Moderately Informative Direct
Biological Process (BP) regulation of programmed cell death 5.364e-10 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 9.134e-10 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 1.966e-09 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 2.816e-07 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 1.202e-05 Moderately Informative Direct
Biological Process (BP) immune system process 2.716e-05 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.0009005 Moderately Informative Direct
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.04698 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.9535 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.3069 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.1999 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organ development 0.004965 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.005013 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.1867 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.9899 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.976 Moderately Informative Inherited
Biological Process (BP) macromolecule catabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.0194 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.6395 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.006362 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.6681 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.05724 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.6917 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.24 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.2314 Moderately Informative Inherited
Biological Process (BP) reproduction 0.0164 Moderately Informative Inherited
Biological Process (BP) tissue development 0.001822 Moderately Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0 Informative Direct
Biological Process (BP) localization of cell 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) cellular component movement 0 Informative Direct
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) biological adhesion 0 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0 Informative Direct
Biological Process (BP) cell projection organization 0 Informative Direct
Biological Process (BP) response to wounding 2.285e-14 Informative Direct
Biological Process (BP) cellular component morphogenesis 1.103e-10 Informative Direct
Biological Process (BP) negative regulation of developmental process 1.417e-10 Informative Direct
Biological Process (BP) growth 6.401e-10 Informative Direct
Biological Process (BP) positive regulation of developmental process 1.902e-09 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 5.765e-09 Informative Direct
Biological Process (BP) vesicle-mediated transport 2.014e-08 Informative Direct
Biological Process (BP) cardiovascular system development 4.172e-08 Informative Direct
Biological Process (BP) positive regulation of cell proliferation 2.988e-07 Informative Direct
Biological Process (BP) central nervous system development 1.418e-06 Informative Direct
Biological Process (BP) regulation of protein phosphorylation 2.136e-06 Informative Direct
Biological Process (BP) tissue morphogenesis 3.763e-06 Informative Direct
Biological Process (BP) positive regulation of protein metabolic process 1.879e-05 Informative Direct
Biological Process (BP) negative regulation of signaling 2.105e-05 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 6.153e-05 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 6.767e-05 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.0001277 Informative Direct
Biological Process (BP) generation of neurons 0.0002491 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.0002686 Informative Direct
Biological Process (BP) response to nutrient levels 0.0004779 Informative Direct
Biological Process (BP) gland development 0.0005694 Informative Direct
Biological Process (BP) organ morphogenesis 0.0006457 Informative Direct
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.2515 Informative Inherited
Biological Process (BP) membrane organization 0.2793 Informative Inherited
Biological Process (BP) protein transport 0.002481 Informative Inherited
Biological Process (BP) muscle tissue development 1 Informative Inherited
Biological Process (BP) muscle structure development 0.5453 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.1285 Informative Inherited
Biological Process (BP) regulation of growth 0.001731 Informative Inherited
Biological Process (BP) cell-cell signaling 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.2786 Informative Inherited
Biological Process (BP) protein complex assembly 0.002153 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 0.007792 Informative Inherited
Biological Process (BP) transmission of nerve impulse 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.1311 Informative Inherited
Biological Process (BP) regulation of secretion 0.1406 Informative Inherited
Biological Process (BP) sensory organ development 0.005034 Informative Inherited
Biological Process (BP) embryonic organ development 0.0211 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.06941 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) secretion by cell 0.01354 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.004298 Informative Inherited
Biological Process (BP) positive regulation of transport 0.3638 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.0931 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.7944 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of gene expression 0.4874 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.8559 Informative Inherited
Biological Process (BP) regulation of cell cycle 1 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.001245 Informative Inherited
Biological Process (BP) regulation of locomotion 0.001261 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.7522 Informative Inherited
Biological Process (BP) protein catabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.9147 Informative Inherited
Biological Process (BP) response to cytokine stimulus 0.3268 Informative Inherited
Biological Process (BP) defense response 0.04984 Informative Inherited
Biological Process (BP) immune response 0.5791 Informative Inherited
Biological Process (BP) immune effector process 0.7822 Informative Inherited
Biological Process (BP) secondary metabolic process 0.07881 Informative Inherited
Biological Process (BP) regulation of purine nucleotide metabolic process 0.001265 Informative Inherited
Biological Process (BP) regulation of nucleotide catabolic process 0.3167 Informative Inherited
Biological Process (BP) regulation of nucleoside metabolic process 0.001065 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.8386 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.6436 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.7042 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 1 Informative Inherited
Biological Process (BP) regulation of cytokine production 1 Informative Inherited
Biological Process (BP) response to lipid 0.447 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.5161 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.09582 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.2453 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.1486 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.4357 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.2801 Informative Inherited
Biological Process (BP) steroid metabolic process 0.001804 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.1359 Informative Inherited
Biological Process (BP) lipid localization 0.3993 Informative Inherited
Biological Process (BP) cell death 0.0641 Informative Inherited
Biological Process (BP) regulation of cell development 0.8849 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) regulation of peptidase activity 0.002777 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.2119 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.3826 Informative Inherited
Biological Process (BP) cytoplasmic transport 1 Informative Inherited
Biological Process (BP) protein localization to organelle 1 Informative Inherited
Biological Process (BP) pigment metabolic process 0.001484 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.01242 Informative Inherited
Biological Process (BP) blood circulation 1 Informative Inherited
Biological Process (BP) epithelium development 0.2016 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.003675 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.116 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.6289 Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 3.083e-05 Highly Informative Direct
Biological Process (BP) protein phosphorylation 0 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0 Highly Informative Direct
Biological Process (BP) chemotaxis 0 Highly Informative Direct
Biological Process (BP) peptidyl-tyrosine modification 0 Highly Informative Direct
Biological Process (BP) cell adhesion 0 Highly Informative Direct
Biological Process (BP) regulation of protein localization to nucleus 2.276e-08 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 4.155e-08 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 7.06e-08 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 9.868e-08 Highly Informative Direct
Biological Process (BP) cell part morphogenesis 1.399e-07 Highly Informative Direct
Biological Process (BP) negative regulation of sequence-specific DNA binding transcription factor activity 2.164e-07 Highly Informative Direct
Biological Process (BP) positive regulation of intracellular transport 3.429e-07 Highly Informative Direct
Biological Process (BP) regulation of cell size 5.006e-07 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 5.282e-07 Highly Informative Direct
Biological Process (BP) negative regulation of secretion 5.779e-07 Highly Informative Direct
Biological Process (BP) positive regulation of protein kinase B signaling cascade 6.78e-07 Highly Informative Direct
Biological Process (BP) plasma membrane organization 1.164e-06 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 3.234e-06 Highly Informative Direct
Biological Process (BP) positive regulation of cell differentiation 3.831e-06 Highly Informative Direct
Biological Process (BP) regulation of cell growth 4.384e-06 Highly Informative Direct
Biological Process (BP) regulation of nucleocytoplasmic transport 6.93e-06 Highly Informative Direct
Biological Process (BP) regulation of intracellular protein transport 8.577e-06 Highly Informative Direct
Biological Process (BP) phagocytosis 1.163e-05 Highly Informative Direct
Biological Process (BP) regulation of ERK1 and ERK2 cascade 1.187e-05 Highly Informative Direct
Biological Process (BP) hormone transport 1.328e-05 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 1.518e-05 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 1.56e-05 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 2.366e-05 Highly Informative Direct
Biological Process (BP) telencephalon development 3.21e-05 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular transport 4.733e-05 Highly Informative Direct
Biological Process (BP) positive regulation of protein transport 6.136e-05 Highly Informative Direct
Biological Process (BP) inner ear development 8.105e-05 Highly Informative Direct
Biological Process (BP) angiogenesis 8.222e-05 Highly Informative Direct
Biological Process (BP) organic hydroxy compound transport 0.0001132 Highly Informative Direct
Biological Process (BP) regulation of mononuclear cell proliferation 0.0001438 Highly Informative Direct
Biological Process (BP) neuron projection development 0.0001668 Highly Informative Direct
Biological Process (BP) pattern specification process 0.0001879 Highly Informative Direct
Biological Process (BP) sterol metabolic process 0.0002214 Highly Informative Direct
Biological Process (BP) multi-organism cellular process 0.0003242 Highly Informative Direct
Biological Process (BP) positive regulation of peptidyl-tyrosine phosphorylation 0.0004435 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0.0005298 Highly Informative Direct
Biological Process (BP) regulation of protein secretion 0.0005991 Highly Informative Direct
Biological Process (BP) regulation of actin cytoskeleton organization 0.0006515 Highly Informative Direct
Biological Process (BP) lipoprotein metabolic process 0.0009573 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.01626 Highly Informative Inherited
Biological Process (BP) stem cell development 0.2736 Highly Informative Inherited
Biological Process (BP) negative regulation of locomotion 0.009563 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular component movement 0.01618 Highly Informative Inherited
Biological Process (BP) regulation of angiogenesis 0.1356 Highly Informative Inherited
Biological Process (BP) cell fate commitment 0.209 Highly Informative Inherited
Biological Process (BP) muscle fiber development 0.001123 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.257 Highly Informative Inherited
Biological Process (BP) response to carbohydrate stimulus 0.006972 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 0.004909 Highly Informative Inherited
Biological Process (BP) developmental growth 0.002197 Highly Informative Inherited
Biological Process (BP) mammary gland epithelium development 0.003213 Highly Informative Inherited
Biological Process (BP) epithelial tube morphogenesis 0.9789 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.07211 Highly Informative Inherited
Biological Process (BP) protein tetramerization 0.001204 Highly Informative Inherited
Biological Process (BP) regulation of binding 0.6491 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.1751 Highly Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 0.0169 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.362 Highly Informative Inherited
Biological Process (BP) negative regulation of growth 0.08236 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.06106 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.4796 Highly Informative Inherited
Biological Process (BP) leukocyte migration 0.00306 Highly Informative Inherited
Biological Process (BP) regulation of synaptic transmission 0.001894 Highly Informative Inherited
Biological Process (BP) signal release 0.6836 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.3209 Highly Informative Inherited
Biological Process (BP) positive regulation of transcription, DNA-dependent 1 Highly Informative Inherited
Biological Process (BP) regulation of mitosis 0.08307 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 0.1382 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.1016 Highly Informative Inherited
Biological Process (BP) interaction with host 0.03134 Highly Informative Inherited
Biological Process (BP) cell proliferation 0.004415 Highly Informative Inherited
Biological Process (BP) regulation of cysteine-type endopeptidase activity 0.05647 Highly Informative Inherited
Biological Process (BP) negative regulation of endopeptidase activity 0.008105 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 1 Highly Informative Inherited
Biological Process (BP) wound healing 0.02058 Highly Informative Inherited
Biological Process (BP) regulation of protein catabolic process 0.3443 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 1 Highly Informative Inherited
Biological Process (BP) positive regulation of leukocyte proliferation 0.8989 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.3121 Highly Informative Inherited
Biological Process (BP) innate immune response 0.08115 Highly Informative Inherited
Biological Process (BP) negative regulation of protein transport 0.002799 Highly Informative Inherited
Biological Process (BP) response to peptide hormone stimulus 0.01634 Highly Informative Inherited
Biological Process (BP) cellular response to peptide 0.05323 Highly Informative Inherited
Biological Process (BP) positive regulation of GTPase activity 0.6607 Highly Informative Inherited
Biological Process (BP) positive regulation of cell activation 0.001698 Highly Informative Inherited
Biological Process (BP) regulation of Ras GTPase activity 0.004103 Highly Informative Inherited
Biological Process (BP) regulation of Rho protein signal transduction 0.005923 Highly Informative Inherited
Biological Process (BP) protein processing 0.001219 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.01659 Highly Informative Inherited
Biological Process (BP) epidermal cell differentiation 0.4254 Highly Informative Inherited
Biological Process (BP) nuclear import 0.01362 Highly Informative Inherited
Biological Process (BP) protein import 0.02238 Highly Informative Inherited
Biological Process (BP) protein localization to nucleus 0.03117 Highly Informative Inherited
Biological Process (BP) protein targeting to nucleus 0.3525 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 0.1273 Highly Informative Inherited
Biological Process (BP) regulation of blood pressure 0.001523 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 1.539e-05 Moderately Informative Direct
Molecular Function (MF) anion binding 0.1705 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) cation binding 1 Moderately Informative Inherited
Molecular Function (MF) structural molecule activity 0.005972 Moderately Informative Inherited
Molecular Function (MF) receptor binding 0 Informative Direct
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0 Informative Direct
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) sulfur compound binding 4.522e-12 Informative Direct
Molecular Function (MF) carbohydrate derivative binding 6.994e-11 Informative Direct
Molecular Function (MF) peptidase regulator activity 4.244e-07 Informative Direct
Molecular Function (MF) enzyme inhibitor activity 1.505e-05 Informative Direct
Molecular Function (MF) enzyme activator activity 6.715e-05 Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 0.1507 Informative Inherited
Molecular Function (MF) carboxylic acid binding 0.003034 Informative Inherited
Molecular Function (MF) amide binding 0.01497 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 0.02091 Informative Inherited
Molecular Function (MF) peptidase activity 0.03022 Informative Inherited
Molecular Function (MF) lipid binding 0.4077 Informative Inherited
Molecular Function (MF) enzyme binding 0.7803 Informative Inherited
Molecular Function (MF) protein kinase activity 0 Highly Informative Direct
Molecular Function (MF) heparin binding 2.136e-11 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 4.225e-11 Highly Informative Direct
Molecular Function (MF) protein kinase regulator activity 1.128e-09 Highly Informative Direct
Molecular Function (MF) calcium ion binding 4.989e-09 Highly Informative Direct
Molecular Function (MF) hormone binding 8.571e-06 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase inhibitor activity 4.944e-05 Highly Informative Direct
Molecular Function (MF) peptide binding 7.252e-05 Highly Informative Direct
Molecular Function (MF) phosphatase regulator activity 0.01366 Highly Informative Inherited
Molecular Function (MF) amino acid binding 0.002285 Highly Informative Inherited
Molecular Function (MF) ion channel activity 0.03008 Highly Informative Inherited
Molecular Function (MF) ion gated channel activity 0.00587 Highly Informative Inherited
Molecular Function (MF) growth factor receptor binding 0.4178 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) plasma membrane part 0 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) vesicle 4.181e-12 Moderately Informative Direct
Cellular Component (CC) cell projection 8.791e-09 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 1 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.02984 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 0.08013 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) endosome 0 Informative Direct
Cellular Component (CC) extracellular matrix 0 Informative Direct
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) Golgi apparatus 2.451e-07 Informative Direct
Cellular Component (CC) lytic vacuole 6.542e-05 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 0.0001508 Informative Direct
Cellular Component (CC) cell leading edge 0.0003956 Informative Direct
Cellular Component (CC) neuron projection 0.9465 Informative Inherited
Cellular Component (CC) synapse part 0.09177 Informative Inherited
Cellular Component (CC) intrinsic to plasma membrane 0.1103 Informative Inherited
Cellular Component (CC) integral to membrane 0.5102 Informative Inherited
Cellular Component (CC) proteinaceous extracellular matrix 0 Highly Informative Direct
Cellular Component (CC) extracellular matrix part 0 Highly Informative Direct
Cellular Component (CC) receptor complex 4.319e-08 Highly Informative Direct
Cellular Component (CC) endosomal part 2.539e-07 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 4.643e-06 Highly Informative Direct
Cellular Component (CC) lysosome 6.829e-06 Highly Informative Direct
Cellular Component (CC) integral to plasma membrane 2.36e-05 Highly Informative Direct
Cellular Component (CC) dendrite 0.000151 Highly Informative Direct
Cellular Component (CC) cell body 0.0003868 Highly Informative Direct
Cellular Component (CC) membrane raft 0.004295 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)8.291e-07Least InformativeDirect
Enzyme Commission (EC)Serine endopeptidases6.22e-06Moderately InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Furin0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

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DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.1126Least InformativeInherited
Disease Ontology (DO)immune system disease0.625Least InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.01342Moderately InformativeInherited
Disease Ontology (DO)cell type cancer0.01477Moderately InformativeInherited
Disease Ontology (DO)benign neoplasm0.08413Moderately InformativeInherited
Disease Ontology (DO)nervous system cancer0.1Moderately InformativeInherited
Disease Ontology (DO)malignant glioma0.0001158InformativeDirect
Disease Ontology (DO)large intestine cancer0.0004271InformativeDirect
Disease Ontology (DO)liver carcinoma0.0009135InformativeDirect
Disease Ontology (DO)organ system benign neoplasm0.0693InformativeInherited
Disease Ontology (DO)peripheral nervous system neoplasm0.4588InformativeInherited
Disease Ontology (DO)primary thrombocytopenia9.041e-06Highly InformativeDirect
Disease Ontology (DO)skin hemangioma9.671e-06Highly InformativeDirect
Disease Ontology (DO)neurofibroma1.535e-05Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

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HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the skeletal system0.2201Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digits0.01052Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hand0.0132Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.04333Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the systemic arterial tree0.3064InformativeInherited
Phenotypic Abnormality (PA)Arachnodactyly0.0004176Highly InformativeDirect
Phenotypic Abnormality (PA)Dilatation of the ascending aorta0.0006653Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

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MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype5.987e-06Least InformativeDirect
Mammalian Phenotype (MP)nervous system phenotype0.1063Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.13Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.7502Least InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology8.092e-06Moderately InformativeDirect
Mammalian Phenotype (MP)renal/urinary system phenotype1.332e-05Moderately InformativeDirect
Mammalian Phenotype (MP)muscle phenotype0.0002554Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal nervous system development0.0006012Moderately InformativeDirect
Mammalian Phenotype (MP)respiratory system phenotype0.002288Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.007777Moderately InformativeInherited
Mammalian Phenotype (MP)digestive/alimentary phenotype0.01596Moderately InformativeInherited
Mammalian Phenotype (MP)preweaning lethality0.08672Moderately InformativeInherited
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.09324Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.0938Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.1022Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.34Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.3454Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.4966Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.5646Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.6514Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lung morphology1.146e-06InformativeDirect
Mammalian Phenotype (MP)abnormal cranium morphology1.559e-05InformativeDirect
Mammalian Phenotype (MP)abnormal membranous labyrinth morphology0.0008072InformativeDirect
Mammalian Phenotype (MP)other phenotype0.0008422InformativeDirect
Mammalian Phenotype (MP)abnormal systemic artery morphology0.02272InformativeInherited
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.02757InformativeInherited
Mammalian Phenotype (MP)abnormal neuron number0.1196InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear sensory epithelium morphology0.3145InformativeInherited
Mammalian Phenotype (MP)abnormal brain development0.3452InformativeInherited
Mammalian Phenotype (MP)abnormal hair cell morphology0.4686InformativeInherited
Mammalian Phenotype (MP)abnormal kidney physiology0.598InformativeInherited
Mammalian Phenotype (MP)decreased cell proliferation0.7113InformativeInherited
Mammalian Phenotype (MP)abnormal intestine morphology0.7448InformativeInherited
Mammalian Phenotype (MP)abnormal aorta tunica media morphology2.943e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cardinal vein morphology0.0001081Highly InformativeDirect
Mammalian Phenotype (MP)decreased organ of Corti supporting cell number0.0002242Highly InformativeDirect
Mammalian Phenotype (MP)aneurysm0.000353Highly InformativeDirect
Mammalian Phenotype (MP)perinatal lethality0.0005798Highly InformativeDirect
Mammalian Phenotype (MP)absent sebaceous gland0.0006596Highly InformativeDirect
Mammalian Phenotype (MP)small kidney0.0007155Highly InformativeDirect
Mammalian Phenotype (MP)abnormal olfactory bulb development0.02063Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear hair cell number0.06149Highly InformativeInherited
Mammalian Phenotype (MP)increased sensory neuron number0.0676Highly InformativeInherited
Mammalian Phenotype (MP)abnormal respiratory system development0.08385Highly InformativeInherited
Mammalian Phenotype (MP)abnormal ureteric bud morphology0.08817Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear inner hair cell morphology0.7306Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

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WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)larval development variant0.4669Least InformativeInherited
Worm Phenotype (WP)organ system development variant3.679e-06Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant1.627e-05Moderately InformativeDirect
Worm Phenotype (WP)locomotion variant0.0006497Moderately InformativeDirect
Worm Phenotype (WP)larval lethal0.2271Moderately InformativeInherited
Worm Phenotype (WP)male morphology variant3.331e-05InformativeDirect
Worm Phenotype (WP)muscle cell morphology variant4.042e-05InformativeDirect
Worm Phenotype (WP)egg laying variant0.0001402InformativeDirect
Worm Phenotype (WP)body length variant0.0002221InformativeDirect
Worm Phenotype (WP)body width variant0.0003162InformativeDirect
Worm Phenotype (WP)activity level variant0.01925InformativeInherited
Worm Phenotype (WP)neuron development variant0.02399InformativeInherited
Worm Phenotype (WP)molt variant1.729e-07Highly InformativeDirect
Worm Phenotype (WP)myopodia present3.625e-07Highly InformativeDirect
Worm Phenotype (WP)loss of asymmetry ASE4.27e-06Highly InformativeDirect
Worm Phenotype (WP)paralyzed1.734e-05Highly InformativeDirect
Worm Phenotype (WP)muscle arm development defective2.228e-05Highly InformativeDirect
Worm Phenotype (WP)axon guidance variant5.658e-05Highly InformativeDirect
Worm Phenotype (WP)dauer arrest variant0.0005952Highly InformativeDirect
Worm Phenotype (WP)muscle system development variant0.005357Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)size defective8.591e-05InformativeDirect
Fly Phenotype (FP)cell polarity defective0.0001312InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

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FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system subdivision0.1027Least InformativeInherited
Fly Anatomy (FA)larva0.2047Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.208Least InformativeInherited
Fly Anatomy (FA)organ system0.2163Least InformativeInherited
Fly Anatomy (FA)anatomical group0.4037Least InformativeInherited
Fly Anatomy (FA)cell0.992Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.01545Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.06534Moderately InformativeInherited
Fly Anatomy (FA)portion of tissue0.06828Moderately InformativeInherited
Fly Anatomy (FA)neuron0.1006Moderately InformativeInherited
Fly Anatomy (FA)adult nervous system0.1365Moderately InformativeInherited
Fly Anatomy (FA)cell cluster organ0.1473Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.153Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.1968Moderately InformativeInherited
Fly Anatomy (FA)sense organ0.2739Moderately InformativeInherited
Fly Anatomy (FA)head0.3803Moderately InformativeInherited
Fly Anatomy (FA)reproductive system0.3932Moderately InformativeInherited
Fly Anatomy (FA)developing material anatomical entity0.5256Moderately InformativeInherited
Fly Anatomy (FA)integumentary specialisation0.0003797InformativeDirect
Fly Anatomy (FA)chemosensory system0.0007078InformativeDirect
Fly Anatomy (FA)tracheal system0.002307InformativeInherited
Fly Anatomy (FA)protocerebrum0.006619InformativeInherited
Fly Anatomy (FA)alimentary canal0.007015InformativeInherited
Fly Anatomy (FA)primordium0.01276InformativeInherited
Fly Anatomy (FA)eye photoreceptor cell0.04627InformativeInherited
Fly Anatomy (FA)circulatory system0.04863InformativeInherited
Fly Anatomy (FA)brain0.05594InformativeInherited
Fly Anatomy (FA)testis0.0718InformativeInherited
Fly Anatomy (FA)ganglion0.1019InformativeInherited
Fly Anatomy (FA)extended germ band embryo0.1076InformativeInherited
Fly Anatomy (FA)presumptive embryonic/larval digestive system0.119InformativeInherited
Fly Anatomy (FA)dorsal closure embryo0.1304InformativeInherited
Fly Anatomy (FA)pupa0.1736InformativeInherited
Fly Anatomy (FA)embryonic/larval central nervous system0.176InformativeInherited
Fly Anatomy (FA)synaptic neuropil domain0.1761InformativeInherited
Fly Anatomy (FA)somatic stem cell0.6362InformativeInherited
Fly Anatomy (FA)ventral nervous system1.067e-05Highly InformativeDirect
Fly Anatomy (FA)hub cell8.031e-05Highly InformativeDirect
Fly Anatomy (FA)adult heart0.0001416Highly InformativeDirect
Fly Anatomy (FA)adult gut0.0003362Highly InformativeDirect
Fly Anatomy (FA)photoreceptor cell R70.0004961Highly InformativeDirect
Fly Anatomy (FA)neuroblast of ventral nerve cord primordium0.002592Highly InformativeInherited
Fly Anatomy (FA)embryonic/larval neuron0.008645Highly InformativeInherited
Fly Anatomy (FA)hindgut0.009409Highly InformativeInherited
Fly Anatomy (FA)larval procephalic segment0.0144Highly InformativeInherited
Fly Anatomy (FA)embryonic/larval brain0.02658Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)portion of tissue0.07746Least InformativeInherited
Zebrafish Anatomy (ZA)multi-tissue structure0.148Least InformativeInherited
Zebrafish Anatomy (ZA)trunk0.3544Least InformativeInherited
Zebrafish Anatomy (ZA)head0.748Least InformativeInherited
Zebrafish Anatomy (ZA)suspensorium0.2855Moderately InformativeInherited
Zebrafish Anatomy (ZA)pharyngeal arch0.7385Moderately InformativeInherited
Zebrafish Anatomy (ZA)somite 20.0002136InformativeDirect
Zebrafish Anatomy (ZA)symplectic0.0003395InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

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XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)central nervous system0.2096Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.4285Least InformativeInherited
Xenopus ANatomical entity (XAN)portion of tissue0.451Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.7676Least InformativeInherited
Xenopus ANatomical entity (XAN)cell1Least InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.009683Moderately InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.1199Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.3332Moderately InformativeInherited
Xenopus ANatomical entity (XAN)surface structure0.9571Moderately InformativeInherited
Xenopus ANatomical entity (XAN)visual system1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)mesoderm1.125e-05InformativeDirect
Xenopus ANatomical entity (XAN)pharyngeal region6.29e-05InformativeDirect
Xenopus ANatomical entity (XAN)neural plate0.0002556InformativeDirect
Xenopus ANatomical entity (XAN)endoderm0.0002622InformativeDirect
Xenopus ANatomical entity (XAN)vestibuloauditory system0.0007092InformativeDirect
Xenopus ANatomical entity (XAN)spinal cord0.002062InformativeInherited
Xenopus ANatomical entity (XAN)tail0.5895InformativeInherited
Xenopus ANatomical entity (XAN)hypochord1.645e-05Highly InformativeDirect
Xenopus ANatomical entity (XAN)mesenchyme3.552e-05Highly InformativeDirect
Xenopus ANatomical entity (XAN)optic vesicle0.0002846Highly InformativeDirect
Xenopus ANatomical entity (XAN)chordoneural hinge0.0004303Highly InformativeDirect
Xenopus ANatomical entity (XAN)floor plate0.00045Highly InformativeDirect
Xenopus ANatomical entity (XAN)zygote0.0008982Highly InformativeDirect
Xenopus ANatomical entity (XAN)intermediate mesoderm0.0009939Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural plate border0.01356Highly InformativeInherited
Xenopus DEvelopment stage (XDE)embryonic stage6.359e-05Least InformativeDirect
Xenopus DEvelopment stage (XDE)NF stage0.0001504Least InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)3.118e-06Moderately InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Serine endopeptidases5.708e-07InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processDifferentiation0Moderately InformativeDirect
Biological processApoptosis7.948e-07Moderately InformativeDirect
Biological processLipid metabolism0.4877Moderately InformativeInherited
Biological processAngiogenesis0InformativeDirect
Biological processCell adhesion0InformativeDirect
Biological processEndocytosis0InformativeDirect
Biological processHemostasis0InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processWnt signaling pathway0InformativeDirect
Biological processSteroid metabolism1.06e-13InformativeDirect
Biological processSensory transduction3.763e-12InformativeDirect
Biological processLipid transport2.379e-11InformativeDirect
Biological processInnate immunity1.113e-06InformativeDirect
Biological processCytolysis9.502e-06InformativeDirect
Biological processBlood coagulation0Highly InformativeDirect
Biological processCholesterol metabolism0Highly InformativeDirect
Biological processGrowth regulation0Highly InformativeDirect
Biological processNotch signaling pathway0Highly InformativeDirect
Biological processComplement alternate pathway3.057e-07Highly InformativeDirect
Biological processDNA synthesis3.42e-06Highly InformativeDirect
Biological processComplement pathway0.0001107Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentEndosome6.167e-13Moderately InformativeDirect
Cellular componentGolgi apparatus0.0002661Moderately InformativeDirect
Cellular componentExtracellular matrix0InformativeDirect
Cellular componentLysosome3.859e-06InformativeDirect
Cellular componentCoated pit0Highly InformativeDirect
Coding sequence diversityPolymorphism1.662e-05Moderately InformativeDirect
DiseaseDisease mutation3.102e-05Least InformativeDirect
DiseaseDwarfism0.0009929Highly InformativeDirect
DomainRepeat0Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane2.263e-08Least InformativeDirect
DomainEGF-like domain0InformativeDirect
DomainANK repeat8.259e-05InformativeDirect
DomainLaminin EGF-like domain6.901e-08Highly InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionHeparin-binding0InformativeDirect
Molecular functionGrowth factor binding0Highly InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationActivator2.749e-09Moderately InformativeDirect
Post-translational modificationProtease4.116e-09Moderately InformativeDirect
Post-translational modificationGrowth factor0InformativeDirect
Post-translational modificationSerine protease0InformativeDirect
Post-translational modificationTyrosine-protein kinase0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues9.085e-16Moderately InformativeDirect
Post-translational modificationHydroxylation0InformativeDirect
Post-translational modificationGamma-carboxyglutamic acid1.45e-13Highly InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR009030 SSF57184 Protein matches
Abstract

The growth factor receptor domain is a cysteine-rich region that is found in a variety of eukaryotic proteins that are involved in the mechanism of signal transduction by receptor tyrosine kinases. Proteins containing the growth factor receptor domain include the insulin-like growth factor-binding proteins (IGFBP) [PubMed11447105], the type-1 insulin-like growth-factor receptor (IGF-1R) [PubMed9690478], and the receptor protein-tyrosine kinase Erbb-3 (ErbB3) [PubMed12154198]. The general structure of the growth factor receptor domain is a disulphide-bound fold containing a beta-hairpin with two adjacent disulphides.

IGFBPs control the distribution, function and activity of insulin-like growth factors (IGFs) IGF-I and IGF-II, which are key regulators of cell proliferation, differentiation and transformation. All IGFBPs share a common domain organization, where the highest conservation is found in the N-terminal Cys-rich IGF-binding domain. The N-terminal domain contains 10-12 conserved cysteine residues.

IGF-1R is a member of the tyrosine-kinase receptor superfamily that is involved in both normal growth and development and malignant transformation. The Cys-rich domain is flanked by two L-domains, and together they contribute to hormone binding and ligand specificity, even though they do not bind ligand directly. The Cys-rich region is composed of eight disulphide-bonded modules, seven of which form a rod-shaped domain.

ErbB3 is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. The extracellular region of ErbB3 is made up of two Cys-rich domains and two L-domains, arranged alternately. The two L-domains and the first Cys-rich domain are structurally homologous to those found in IGF-1R. The two Cys-rich domains are extended repeats of seven small disulphide-containing modules. A beta-hairpin loop extends from the first Cys-rich domain to contact the C-terminal portion of the second Cys-rich domain, creating a large pore structure.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 12 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Growth factor receptor domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 12 hidden Markov models representing the Growth factor receptor domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]