SUPERFAMILY 1.75 HMM library and genome assignments server

Scorpion toxin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Knottins (small inhibitors, toxins, lectins) [ 57015] (19)
Superfamily:   Scorpion toxin-like [ 57095] (5)
Families:   Long-chain scorpion toxins [ 57096] (4)
  Short-chain scorpion toxins [ 57116] (34)
  Defensin MGD-1 [ 57160]
  Insect defensins [ 57163] (5)
  Plant defensins [ 57170] (8)

Superfamily statistics
Genomes (99) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 699 2,054 99
Proteins 694 2,050 99

Functional annotation
General category Processes_EC
Detailed category Toxins/defense

Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus00Least InformativeDirect
Biological Process (BP)multi-organism process00Moderately InformativeDirect
Biological Process (BP)defense response00InformativeDirect
Biological Process (BP)response to bacterium11InformativeInherited
Biological Process (BP)response to fungus2.926e-140Highly InformativeDirect
Biological Process (BP)pathogenesis2.75e-065.851e-07Highly InformativeDirect
Biological Process (BP)defense response to bacterium0.66130.2395Highly InformativeInherited
Molecular Function (MF)channel regulator activity00Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) multi-organism process 0 Moderately Informative Direct
Biological Process (BP) defense response 0 Informative Direct
Biological Process (BP) response to bacterium 1 Informative Inherited
Biological Process (BP) response to fungus 0 Highly Informative Direct
Biological Process (BP) pathogenesis 5.851e-07 Highly Informative Direct
Biological Process (BP) defense response to bacterium 0.2395 Highly Informative Inherited
Molecular Function (MF) channel regulator activity 0 Highly Informative Direct
Cellular Component (CC) extracellular region part 0.02516 Moderately Informative Inherited
Cellular Component (CC) extracellular space 0.00025 Informative Direct

Document: GO annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processInnate immunity0InformativeDirect
Biological processPlant defense0InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Coding sequence diversityRNA editing2.236e-10Moderately InformativeDirect
DomainSignal0Least InformativeDirect
DomainKnottin0Highly InformativeDirect
Post-translational modificationToxin0InformativeDirect
Post-translational modificationAntimicrobial0InformativeDirect
Post-translational modificationNeurotoxin0Highly InformativeDirect
Post-translational modificationIon channel impairing toxin0Highly InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationPyrrolidone carboxylic acid1.354e-15InformativeDirect
Post-translational modificationAmidation0Highly InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 74 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a Scorpion toxin-like domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 74 hidden Markov models representing the Scorpion toxin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]