SUPERFAMILY 1.75 HMM library and genome assignments server


Plant inhibitors of proteinases and amylases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Knottins (small inhibitors, toxins, lectins) [ 57015] (19)
Superfamily:   Plant inhibitors of proteinases and amylases [ 57027]
Families:   Plant inhibitors of proteinases and amylases [ 57028] (3)


Superfamily statistics
Genomes (3) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 7 72 18
Proteins 7 51 18


Functional annotation
General category Processes_EC
Detailed category Toxins/defense

Document:
Function annotation of SCOP domain superfamilies

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentSecreted0Moderately InformativeDirect
DomainKnottin0Highly InformativeDirect
Post-translational modificationProtease inhibitor0InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR011052 SSF57027 Protein matches
Abstract

This family includes inhibitors of proteinases and amylases, such as trypsin inhibitors [PubMed12198301], carboxypeptidase A inhibitors [PubMed12557184], and alpha-amylase inhibitors (AAI) [PubMed11298757]. The proteins display a knottins-like (small inhibitors, toxins, lectins) disulphide-bound fold, containing a beta-hairpin with two adjacent disulphides.

More information about this protein can be found at Protein of the Month: alpha-Amylase.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 12 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Plant inhibitors of proteinases and amylases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 12 hidden Markov models representing the Plant inhibitors of proteinases and amylases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · UniProtKB KeyWords (KW) · Internal database links ]