SUPERFAMILY 1.75 HMM library and genome assignments server


Insulin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Insulin-like [ 56993]
Superfamily:   Insulin-like [ 56994]
Families:   Insulin-like [ 56995] (4)


Superfamily statistics
Genomes (131) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 924 0 48
Proteins 919 0 48


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process1.628e-089.491e-14Least InformativeDirect
Biological Process (BP)developmental process2.423e-075.799e-10Least InformativeDirect
Biological Process (BP)response to stimulus2.166e-050.0004141Least InformativeDirect
Biological Process (BP)regulation of cellular process0.10890.004757Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.24510.3399Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.014670.03006Least InformativeInherited
Biological Process (BP)localization0.0018030.661Least InformativeInherited
Biological Process (BP)single-organism cellular process0.14210.249Least InformativeInherited
Biological Process (BP)response to endogenous stimulus2.049e-074.841e-08Moderately InformativeDirect
Biological Process (BP)regulation of biosynthetic process3.768e-100Moderately InformativeDirect
Biological Process (BP)positive regulation of metabolic process3.317e-110Moderately InformativeDirect
Biological Process (BP)regulation of signal transduction0.00085886.688e-08Moderately InformativeDirect
Biological Process (BP)response to organic substance3.448e-101.83e-08Moderately InformativeDirect
Biological Process (BP)cell differentiation8.24e-061.204e-06Moderately InformativeDirect
Biological Process (BP)positive regulation of molecular function3.919e-088.845e-06Moderately InformativeDirect
Biological Process (BP)single-organism developmental process0.00023053.713e-06Moderately InformativeDirect
Biological Process (BP)response to oxygen-containing compound9.249e-127.57e-12Moderately InformativeDirect
Biological Process (BP)cellular response to chemical stimulus0.00027820.01543Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.0023570.001214Moderately InformativeInherited
Biological Process (BP)regulation of catalytic activity0.014660.4692Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process15.81e-13Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.011130.9447Moderately InformativeInherited
Biological Process (BP)carbohydrate metabolic process1.377e-050.01604Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.00089670.2371Moderately InformativeInherited
Biological Process (BP)tissue development0.016190.1005Moderately InformativeInherited
Biological Process (BP)organic substance transport2.989e-070.00417Moderately InformativeInherited
Biological Process (BP)organ development0.0053820.002467Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.035760.05436Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.03350.0009411Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.022150.1418Moderately InformativeInherited
Biological Process (BP)signal transduction0.025510.006447Moderately InformativeInherited
Biological Process (BP)regulation of protein phosphorylation1.466e-110InformativeDirect
Biological Process (BP)enzyme linked receptor protein signaling pathway01.15e-10InformativeDirect
Biological Process (BP)response to hormone stimulus4.587e-052.166e-09InformativeDirect
Biological Process (BP)response to organonitrogen compound1.164e-061.11e-09InformativeDirect
Biological Process (BP)programmed cell death3.796e-081.537e-11InformativeDirect
Biological Process (BP)lipid catabolic process9.446e-101.209e-06InformativeDirect
Biological Process (BP)regulation of lipid metabolic process1.941e-072.253e-05InformativeDirect
Biological Process (BP)hexose metabolic process8.023e-091.466e-05InformativeDirect
Biological Process (BP)regulation of apoptotic process0.00014570InformativeDirect
Biological Process (BP)muscle structure development2.466e-070.0003458InformativeDirect
Biological Process (BP)cellular response to nitrogen compound1.897e-081.314e-11InformativeDirect
Biological Process (BP)cellular response to oxygen-containing compound0.000221.271e-06InformativeDirect
Biological Process (BP)regulation of response to stress0.062191InformativeInherited
Biological Process (BP)cellular response to endogenous stimulus0.0068410.01601InformativeInherited
Biological Process (BP)muscle tissue development9.109e-120.009907InformativeInherited
Biological Process (BP)regulation of intracellular protein kinase cascade0.080080.5675InformativeInherited
Biological Process (BP)regulation of kinase activity0.036481InformativeInherited
Biological Process (BP)positive regulation of signal transduction0.03330.2818InformativeInherited
Biological Process (BP)positive regulation of protein modification process2.065e-120.3098InformativeInherited
Biological Process (BP)positive regulation of phosphate metabolic process2.01e-120.03154InformativeInherited
Biological Process (BP)intracellular signal transduction0.003860.7557InformativeInherited
Biological Process (BP)anatomical structure formation involved in morphogenesis0.0010650.3643InformativeInherited
Biological Process (BP)MAPK cascade1.398e-121.132e-07Highly InformativeDirect
Biological Process (BP)ER-nucleus signaling pathway3.491e-090.0001483Highly InformativeDirect
Biological Process (BP)transmembrane receptor protein tyrosine kinase signaling pathway00Highly InformativeDirect
Biological Process (BP)carbohydrate transport01.217e-11Highly InformativeDirect
Biological Process (BP)stress-activated protein kinase signaling cascade7.643e-102.839e-09Highly InformativeDirect
Biological Process (BP)response to endoplasmic reticulum stress6.588e-123.983e-07Highly InformativeDirect
Biological Process (BP)response to peptide hormone stimulus03.74e-08Highly InformativeDirect
Biological Process (BP)positive regulation of lipid metabolic process8.463e-081.726e-06Highly InformativeDirect
Biological Process (BP)regulation of binding4.71e-081.283e-06Highly InformativeDirect
Biological Process (BP)cellular response to biotic stimulus3.527e-103.373e-06Highly InformativeDirect
Biological Process (BP)regulation of cellular response to insulin stimulus9.495e-108.549e-09Highly InformativeDirect
Biological Process (BP)cellular response to peptide9.243e-082.406e-11Highly InformativeDirect
Biological Process (BP)intrinsic apoptotic signaling pathway4.696e-060.002048Highly InformativeInherited
Biological Process (BP)regulation of cellular response to stress6.228e-070.01059Highly InformativeInherited
Biological Process (BP)muscle organ development1.043e-060.01654Highly InformativeInherited
Biological Process (BP)regulation of MAP kinase activity0.0012090.7132Highly InformativeInherited
Biological Process (BP)positive regulation of MAPK cascade1.187e-120.4367Highly InformativeInherited
Biological Process (BP)positive regulation of protein kinase activity0.0032590.03851Highly InformativeInherited
Molecular Function (MF)binding0.00038991.26e-10Least InformativeDirect
Molecular Function (MF)receptor binding3.439e-090InformativeDirect
Molecular Function (MF)protein complex binding2.959e-094.58e-11Highly InformativeDirect
Cellular Component (CC)cytoplasmic part0.00620.9382Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.34391Least InformativeInherited
Cellular Component (CC)vesicle3.816e-105.999e-06Moderately InformativeDirect
Cellular Component (CC)extracellular region part0.00064924.133e-12Moderately InformativeDirect
Cellular Component (CC)ribonucleoprotein complex6.394e-070.002423Moderately InformativeInherited
Cellular Component (CC)secretory granule04.676e-15InformativeDirect
Cellular Component (CC)small nucleolar ribonucleoprotein complex8.503e-151.618e-12Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 9.491e-14 Least Informative Direct
Biological Process (BP) developmental process 5.799e-10 Least Informative Direct
Biological Process (BP) response to stimulus 0.0004141 Least Informative Direct
Biological Process (BP) biosynthetic process 0.4385 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.004757 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.3399 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.03006 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.647 Least Informative Inherited
Biological Process (BP) localization 0.661 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.249 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.2141 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.7745 Least Informative Inherited
Biological Process (BP) reproduction 9.521e-11 Moderately Informative Direct
Biological Process (BP) sulfur compound metabolic process 7.878e-06 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 4.841e-08 Moderately Informative Direct
Biological Process (BP) regulation of biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 6.688e-08 Moderately Informative Direct
Biological Process (BP) response to organic substance 1.83e-08 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 5.81e-13 Moderately Informative Direct
Biological Process (BP) cell differentiation 1.204e-06 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 8.845e-06 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 3.713e-06 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.0009411 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 2.216e-05 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 5.368e-05 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 7.57e-12 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.01543 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.006447 Moderately Informative Inherited
Biological Process (BP) tissue development 0.1005 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.1418 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.9001 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.004348 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.01124 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.002213 Moderately Informative Inherited
Biological Process (BP) organ development 0.002467 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.006292 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.08714 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.001214 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.4692 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.9447 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.008332 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.9472 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.01604 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.2371 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.05436 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.00417 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.0002666 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 1.15e-10 Informative Direct
Biological Process (BP) response to hormone stimulus 2.166e-09 Informative Direct
Biological Process (BP) response to organonitrogen compound 1.11e-09 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1.417e-06 Informative Direct
Biological Process (BP) programmed cell death 1.537e-11 Informative Direct
Biological Process (BP) lipid catabolic process 1.209e-06 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 2.253e-05 Informative Direct
Biological Process (BP) hexose metabolic process 1.466e-05 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 1.642e-07 Informative Direct
Biological Process (BP) regulation of organelle organization 1.801e-10 Informative Direct
Biological Process (BP) growth 3.83e-09 Informative Direct
Biological Process (BP) regulation of apoptotic process 0 Informative Direct
Biological Process (BP) sulfur compound biosynthetic process 1.425e-07 Informative Direct
Biological Process (BP) gland development 5.073e-06 Informative Direct
Biological Process (BP) positive regulation of transport 2.61e-06 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 1.116e-11 Informative Direct
Biological Process (BP) regulation of nervous system development 0.0001254 Informative Direct
Biological Process (BP) negative regulation of cell death 0 Informative Direct
Biological Process (BP) muscle structure development 0.0003458 Informative Direct
Biological Process (BP) reproductive system development 1.243e-05 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 1.314e-11 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 1.271e-06 Informative Direct
Biological Process (BP) regulation of cell proliferation 0.02416 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.02098 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.01387 Informative Inherited
Biological Process (BP) organ morphogenesis 0.1362 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.004453 Informative Inherited
Biological Process (BP) epithelium development 0.7461 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.1339 Informative Inherited
Biological Process (BP) cardiovascular system development 0.2343 Informative Inherited
Biological Process (BP) tube development 0.04055 Informative Inherited
Biological Process (BP) sensory organ development 0.06746 Informative Inherited
Biological Process (BP) regulation of response to stress 1 Informative Inherited
Biological Process (BP) response to wounding 0.01837 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.0104 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.01601 Informative Inherited
Biological Process (BP) muscle tissue development 0.009907 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.2818 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.5675 Informative Inherited
Biological Process (BP) regulation of kinase activity 1 Informative Inherited
Biological Process (BP) positive regulation of protein modification process 0.3098 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.03154 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.7557 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.3643 Informative Inherited
Biological Process (BP) MAPK cascade 1.132e-07 Highly Informative Direct
Biological Process (BP) aminoglycan biosynthetic process 2.21e-11 Highly Informative Direct
Biological Process (BP) ER-nucleus signaling pathway 0.0001483 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0 Highly Informative Direct
Biological Process (BP) carbohydrate transport 1.217e-11 Highly Informative Direct
Biological Process (BP) glial cell differentiation 3.07e-06 Highly Informative Direct
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of mitochondrion organization 0 Highly Informative Direct
Biological Process (BP) glycosaminoglycan metabolic process 3.226e-10 Highly Informative Direct
Biological Process (BP) respiratory tube development 2.675e-05 Highly Informative Direct
Biological Process (BP) stress-activated protein kinase signaling cascade 2.839e-09 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 3.983e-07 Highly Informative Direct
Biological Process (BP) wound healing 0.0001103 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic process 1.745e-09 Highly Informative Direct
Biological Process (BP) response to peptide hormone stimulus 3.74e-08 Highly Informative Direct
Biological Process (BP) positive regulation of lipid metabolic process 1.726e-06 Highly Informative Direct
Biological Process (BP) regulation of glucose import 0 Highly Informative Direct
Biological Process (BP) developmental growth 5.523e-07 Highly Informative Direct
Biological Process (BP) branching morphogenesis of an epithelial tube 2.643e-08 Highly Informative Direct
Biological Process (BP) inner ear development 0.0001162 Highly Informative Direct
Biological Process (BP) regulation of binding 1.283e-06 Highly Informative Direct
Biological Process (BP) regulation of protein kinase B signaling cascade 4.872e-05 Highly Informative Direct
Biological Process (BP) connective tissue development 9.088e-05 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 3.373e-06 Highly Informative Direct
Biological Process (BP) extrinsic apoptotic signaling pathway 5.412e-06 Highly Informative Direct
Biological Process (BP) regulation of cellular response to insulin stimulus 8.549e-09 Highly Informative Direct
Biological Process (BP) cellular response to peptide 2.406e-11 Highly Informative Direct
Biological Process (BP) regulation of neural precursor cell proliferation 2.588e-06 Highly Informative Direct
Biological Process (BP) regulation of ERK1 and ERK2 cascade 0.08607 Highly Informative Inherited
Biological Process (BP) intrinsic apoptotic signaling pathway 0.002048 Highly Informative Inherited
Biological Process (BP) respiratory system development 0.001339 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.01059 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.01654 Highly Informative Inherited
Biological Process (BP) regulation of MAP kinase activity 0.7132 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 0.4367 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 0.03851 Highly Informative Inherited
Molecular Function (MF) binding 1.26e-10 Least Informative Direct
Molecular Function (MF) receptor binding 0 Informative Direct
Molecular Function (MF) protein complex binding 4.58e-11 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.9382 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) vesicle 5.999e-06 Moderately Informative Direct
Cellular Component (CC) extracellular region part 4.133e-12 Moderately Informative Direct
Cellular Component (CC) ribonucleoprotein complex 0.002423 Moderately Informative Inherited
Cellular Component (CC) secretory granule 4.676e-15 Informative Direct
Cellular Component (CC) small nucleolar ribonucleoprotein complex 1.618e-12 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0Least InformativeDirect
Disease Ontology (DO)nervous system disease0.4305Least InformativeInherited
Disease Ontology (DO)cell type cancer0Moderately InformativeDirect
Disease Ontology (DO)artery disease0Moderately InformativeDirect
Disease Ontology (DO)disease of metabolism0.0004396Moderately InformativeDirect
Disease Ontology (DO)endocrine system disease0.0005818Moderately InformativeDirect
Disease Ontology (DO)lung disease0.006679Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.01739Moderately InformativeInherited
Disease Ontology (DO)syndrome0.01903Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.1148Moderately InformativeInherited
Disease Ontology (DO)hypertension0InformativeDirect
Disease Ontology (DO)overnutrition3.386e-05InformativeDirect
Disease Ontology (DO)in situ carcinoma9.067e-05InformativeDirect
Disease Ontology (DO)motor neuron disease0.0001251InformativeDirect
Disease Ontology (DO)endocrine gland cancer0.001858InformativeInherited
Disease Ontology (DO)liver disease0.005764InformativeInherited
Disease Ontology (DO)pancreas disease0.1199InformativeInherited
Disease Ontology (DO)hyperandrogenism1.121e-07Highly InformativeDirect
Disease Ontology (DO)polycystic ovary syndrome1.02e-06Highly InformativeDirect
Disease Ontology (DO)interstitial lung disease0.0001097Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.04815Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body phenotype0.1996Least InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal skeleton morphology0.007952Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.1726Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal male germ cell morphology0.0009605InformativeDirect
Mammalian Phenotype (MP)abnormal bone mineral density0.00183InformativeInherited
Mammalian Phenotype (MP)abnormal prenatal growth/weight/body size0.0178InformativeInherited
Mammalian Phenotype (MP)abnormal circulating glucose level0.02163InformativeInherited
Mammalian Phenotype (MP)abnormal sex determination0.1013InformativeInherited
Mammalian Phenotype (MP)abnormal pancreas morphology0.1193InformativeInherited
Mammalian Phenotype (MP)decreased birth weight1.569e-06Highly InformativeDirect
Mammalian Phenotype (MP)decreased fetal size0.0005703Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pancreatic islet morphology0.0007686Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.0002272Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.05851Least InformativeInherited
Worm Phenotype (WP)locomotion variant1.298e-05Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant9.153e-05Moderately InformativeDirect
Worm Phenotype (WP)lipid metabolism variant0.0003172InformativeDirect
Worm Phenotype (WP)body length variant0.0004554InformativeDirect
Worm Phenotype (WP)body width variant0.0006215InformativeDirect
Worm Phenotype (WP)dauer development variant1.519e-10Highly InformativeDirect
Worm Phenotype (WP)dauer arrest variant8.647e-10Highly InformativeDirect
Worm Phenotype (WP)small2.592e-06Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)mating defective9.306e-05Highly InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)alimentary system0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus DEvelopment stage (XDE)embryonic stage0Least InformativeDirect
Xenopus DEvelopment stage (XDE)NF stage0Least InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processGlucose metabolism0Highly InformativeDirect
Biological processOsteogenesis0Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
DomainSignal0Least InformativeDirect
Post-translational modificationGrowth factor0InformativeDirect
Post-translational modificationHormone0Highly InformativeDirect
Post-translational modificationMitogen0Highly InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues0Moderately InformativeDirect
Post-translational modificationPyrrolidone carboxylic acid0InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 11 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Insulin-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 11 hidden Markov models representing the Insulin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]