SUPERFAMILY 1.75 HMM library and genome assignments server


Insulin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Insulin-like [ 56993]
Superfamily:   Insulin-like [ 56994]
Families:   Insulin-like [ 56995] (4)


Superfamily statistics
Genomes (136) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 959 1,683 48
Proteins 954 1,680 48


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process2.117e-083.3e-13Least InformativeDirect
Biological Process (BP)developmental process3.115e-071.52e-09Least InformativeDirect
Biological Process (BP)response to stimulus3.173e-050.0009074Least InformativeDirect
Biological Process (BP)regulation of cellular process0.0990.004516Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.23590.3376Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.018680.04198Least InformativeInherited
Biological Process (BP)localization0.0020590.717Least InformativeInherited
Biological Process (BP)single-organism cellular process0.14030.2476Least InformativeInherited
Biological Process (BP)response to endogenous stimulus2.428e-077.542e-08Moderately InformativeDirect
Biological Process (BP)positive regulation of metabolic process5.756e-110Moderately InformativeDirect
Biological Process (BP)regulation of signal transduction0.00074685.002e-08Moderately InformativeDirect
Biological Process (BP)response to organic substance5.662e-104.863e-08Moderately InformativeDirect
Biological Process (BP)regulation of macromolecule biosynthetic process1.28e-104.918e-05Moderately InformativeDirect
Biological Process (BP)cell differentiation1.016e-052.206e-06Moderately InformativeDirect
Biological Process (BP)regulation of cellular biosynthetic process3.724e-100Moderately InformativeDirect
Biological Process (BP)positive regulation of molecular function3.741e-081.214e-05Moderately InformativeDirect
Biological Process (BP)response to oxygen-containing compound1.392e-111.832e-11Moderately InformativeDirect
Biological Process (BP)cellular response to chemical stimulus0.00026290.01666Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.0024970.001245Moderately InformativeInherited
Biological Process (BP)regulation of catalytic activity0.01220.4565Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process11.328e-12Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.010960.9481Moderately InformativeInherited
Biological Process (BP)carbohydrate metabolic process1.646e-050.01889Moderately InformativeInherited
Biological Process (BP)lipid metabolic process5.364e-050.03147Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.0011160.2697Moderately InformativeInherited
Biological Process (BP)tissue development0.01670.1036Moderately InformativeInherited
Biological Process (BP)organic substance transport3.442e-070.005031Moderately InformativeInherited
Biological Process (BP)organ development0.0056380.002499Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.036730.001213Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.035180.05677Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.023710.1439Moderately InformativeInherited
Biological Process (BP)signal transduction0.02410.005807Moderately InformativeInherited
Biological Process (BP)regulation of protein phosphorylation2.088e-110InformativeDirect
Biological Process (BP)apoptotic process2.208e-083.068e-12InformativeDirect
Biological Process (BP)enzyme linked receptor protein signaling pathway01.649e-10InformativeDirect
Biological Process (BP)response to hormone stimulus5.175e-052.665e-09InformativeDirect
Biological Process (BP)response to organonitrogen compound9.433e-078.616e-10InformativeDirect
Biological Process (BP)lipid catabolic process1.172e-091.595e-06InformativeDirect
Biological Process (BP)regulation of lipid metabolic process2.044e-072.407e-05InformativeDirect
Biological Process (BP)hexose metabolic process8.904e-091.728e-05InformativeDirect
Biological Process (BP)single-organism behavior0.00014679.733e-05InformativeDirect
Biological Process (BP)muscle structure development3.219e-070.0003793InformativeDirect
Biological Process (BP)cellular response to nitrogen compound2.112e-081.309e-11InformativeDirect
Biological Process (BP)cellular response to oxygen-containing compound0.0002381.322e-06InformativeDirect
Biological Process (BP)cellular response to endogenous stimulus0.005770.01324InformativeInherited
Biological Process (BP)muscle tissue development1.648e-110.0104InformativeInherited
Biological Process (BP)regulation of intracellular protein kinase cascade0.088150.6045InformativeInherited
Biological Process (BP)positive regulation of phosphate metabolic process3.14e-120.03725InformativeInherited
Biological Process (BP)positive regulation of protein metabolic process0.00094920.1965InformativeInherited
Biological Process (BP)regulation of kinase activity0.0291InformativeInherited
Biological Process (BP)positive regulation of signal transduction0.036250.2787InformativeInherited
Biological Process (BP)intracellular signal transduction0.0034940.7209InformativeInherited
Biological Process (BP)anatomical structure formation involved in morphogenesis0.0012030.3818InformativeInherited
Biological Process (BP)MAPK cascade1.827e-121.375e-07Highly InformativeDirect
Biological Process (BP)ER-nucleus signaling pathway2.894e-090.0001417Highly InformativeDirect
Biological Process (BP)transmembrane receptor protein tyrosine kinase signaling pathway00Highly InformativeDirect
Biological Process (BP)carbohydrate transport01.553e-11Highly InformativeDirect
Biological Process (BP)stress-activated protein kinase signaling cascade6.843e-103.161e-09Highly InformativeDirect
Biological Process (BP)response to endoplasmic reticulum stress6.832e-126.178e-07Highly InformativeDirect
Biological Process (BP)response to peptide hormone stimulus02.352e-08Highly InformativeDirect
Biological Process (BP)positive regulation of lipid metabolic process6.251e-081.354e-06Highly InformativeDirect
Biological Process (BP)regulation of peptidyl-tyrosine phosphorylation01.656e-05Highly InformativeDirect
Biological Process (BP)regulation of binding5.374e-081.585e-06Highly InformativeDirect
Biological Process (BP)cellular response to biotic stimulus5.446e-104.009e-06Highly InformativeDirect
Biological Process (BP)regulation of cellular response to insulin stimulus1.052e-091.171e-08Highly InformativeDirect
Biological Process (BP)cellular response to peptide9.027e-082.246e-11Highly InformativeDirect
Biological Process (BP)intrinsic apoptotic signaling pathway4.853e-060.002194Highly InformativeInherited
Biological Process (BP)regulation of cellular response to stress7.058e-070.01225Highly InformativeInherited
Biological Process (BP)muscle organ development1.493e-060.01934Highly InformativeInherited
Biological Process (BP)regulation of MAP kinase activity0.00099140.6702Highly InformativeInherited
Biological Process (BP)positive regulation of MAPK cascade2.06e-120.4608Highly InformativeInherited
Biological Process (BP)positive regulation of protein kinase activity0.0027210.0324Highly InformativeInherited
Molecular Function (MF)binding0.00056366.283e-10Least InformativeDirect
Molecular Function (MF)receptor binding3.215e-090InformativeDirect
Molecular Function (MF)protein complex binding3.157e-095.192e-11Highly InformativeDirect
Cellular Component (CC)cytoplasmic part0.0077020.9956Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.3371Least InformativeInherited
Cellular Component (CC)vesicle6.942e-101.299e-05Moderately InformativeDirect
Cellular Component (CC)extracellular region part0.00082341.262e-11Moderately InformativeDirect
Cellular Component (CC)ribonucleoprotein complex6.231e-070.00283Moderately InformativeInherited
Cellular Component (CC)extracellular space6.017e-054.78e-06InformativeDirect
Cellular Component (CC)secretory granule06.088e-15InformativeDirect
Cellular Component (CC)small nucleolar ribonucleoprotein complex8.226e-151.794e-12Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 3.3e-13 Least Informative Direct
Biological Process (BP) developmental process 1.52e-09 Least Informative Direct
Biological Process (BP) response to stimulus 0.0009074 Least Informative Direct
Biological Process (BP) biosynthetic process 0.4948 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.004516 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.3376 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.04198 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.707 Least Informative Inherited
Biological Process (BP) localization 0.717 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.2476 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.2458 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.8233 Least Informative Inherited
Biological Process (BP) reproduction 1.864e-10 Moderately Informative Direct
Biological Process (BP) sulfur compound metabolic process 1.161e-05 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 7.542e-08 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 5.002e-08 Moderately Informative Direct
Biological Process (BP) response to organic substance 4.863e-08 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 4.918e-05 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 1.328e-12 Moderately Informative Direct
Biological Process (BP) cell differentiation 2.206e-06 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 1.214e-05 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 2.927e-05 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 5.721e-05 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 1.832e-11 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.01666 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.005807 Moderately Informative Inherited
Biological Process (BP) tissue development 0.1036 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.1439 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.908 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.005646 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.01338 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.003038 Moderately Informative Inherited
Biological Process (BP) organ development 0.002499 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.00693 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.1165 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.001245 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.4565 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.9481 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.9534 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.01889 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.03147 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.2697 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.05677 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.001213 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.005031 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.000314 Informative Direct
Biological Process (BP) apoptotic process 3.068e-12 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 1.649e-10 Informative Direct
Biological Process (BP) response to hormone stimulus 2.665e-09 Informative Direct
Biological Process (BP) response to organonitrogen compound 8.616e-10 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1.514e-06 Informative Direct
Biological Process (BP) lipid catabolic process 1.595e-06 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 2.407e-05 Informative Direct
Biological Process (BP) hexose metabolic process 1.728e-05 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 1.728e-07 Informative Direct
Biological Process (BP) regulation of organelle organization 2.576e-10 Informative Direct
Biological Process (BP) growth 3.786e-08 Informative Direct
Biological Process (BP) sulfur compound biosynthetic process 2.129e-07 Informative Direct
Biological Process (BP) multi-multicellular organism process 0.0003158 Informative Direct
Biological Process (BP) single-organism behavior 9.733e-05 Informative Direct
Biological Process (BP) gland development 4.818e-06 Informative Direct
Biological Process (BP) positive regulation of transport 2.67e-06 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 1.036e-11 Informative Direct
Biological Process (BP) regulation of nervous system development 0.0001684 Informative Direct
Biological Process (BP) negative regulation of cell death 0 Informative Direct
Biological Process (BP) muscle structure development 0.0003793 Informative Direct
Biological Process (BP) reproductive system development 1.452e-05 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 1.309e-11 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 1.322e-06 Informative Direct
Biological Process (BP) regulation of apoptotic signaling pathway 6.638e-11 Informative Direct
Biological Process (BP) regulation of cell proliferation 0.02354 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.02361 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.01567 Informative Inherited
Biological Process (BP) organ morphogenesis 0.1328 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.00489 Informative Inherited
Biological Process (BP) epithelium development 0.7369 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.1356 Informative Inherited
Biological Process (BP) cardiovascular system development 0.2305 Informative Inherited
Biological Process (BP) tube development 0.03895 Informative Inherited
Biological Process (BP) sensory organ development 0.06607 Informative Inherited
Biological Process (BP) response to wounding 0.01762 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.01162 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.01324 Informative Inherited
Biological Process (BP) muscle tissue development 0.0104 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.2787 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.6045 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.03725 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 0.1965 Informative Inherited
Biological Process (BP) regulation of kinase activity 1 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.7209 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.3818 Informative Inherited
Biological Process (BP) MAPK cascade 1.375e-07 Highly Informative Direct
Biological Process (BP) aminoglycan biosynthetic process 3.502e-11 Highly Informative Direct
Biological Process (BP) ER-nucleus signaling pathway 0.0001417 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0 Highly Informative Direct
Biological Process (BP) carbohydrate transport 1.553e-11 Highly Informative Direct
Biological Process (BP) glial cell differentiation 3.988e-06 Highly Informative Direct
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of mitochondrion organization 0 Highly Informative Direct
Biological Process (BP) glycosaminoglycan metabolic process 5.315e-10 Highly Informative Direct
Biological Process (BP) respiratory tube development 2.521e-05 Highly Informative Direct
Biological Process (BP) stress-activated protein kinase signaling cascade 3.161e-09 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 6.178e-07 Highly Informative Direct
Biological Process (BP) wound healing 0.0001421 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic process 1.813e-09 Highly Informative Direct
Biological Process (BP) response to peptide hormone stimulus 2.352e-08 Highly Informative Direct
Biological Process (BP) ear development 0.0003461 Highly Informative Direct
Biological Process (BP) positive regulation of lipid metabolic process 1.354e-06 Highly Informative Direct
Biological Process (BP) regulation of glucose import 0 Highly Informative Direct
Biological Process (BP) developmental growth 4.217e-07 Highly Informative Direct
Biological Process (BP) branching morphogenesis of an epithelial tube 2.999e-08 Highly Informative Direct
Biological Process (BP) regulation of peptidyl-tyrosine phosphorylation 1.656e-05 Highly Informative Direct
Biological Process (BP) regulation of binding 1.585e-06 Highly Informative Direct
Biological Process (BP) regulation of protein kinase B signaling cascade 4.266e-05 Highly Informative Direct
Biological Process (BP) connective tissue development 0.0001009 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 4.009e-06 Highly Informative Direct
Biological Process (BP) extrinsic apoptotic signaling pathway 4.96e-06 Highly Informative Direct
Biological Process (BP) regulation of cellular response to insulin stimulus 1.171e-08 Highly Informative Direct
Biological Process (BP) cellular response to peptide 2.246e-11 Highly Informative Direct
Biological Process (BP) regulation of neural precursor cell proliferation 3.025e-06 Highly Informative Direct
Biological Process (BP) intrinsic apoptotic signaling pathway 0.002194 Highly Informative Inherited
Biological Process (BP) respiratory system development 0.001244 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.01225 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.01934 Highly Informative Inherited
Biological Process (BP) regulation of MAP kinase activity 0.6702 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 0.4608 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 0.0324 Highly Informative Inherited
Molecular Function (MF) binding 6.283e-10 Least Informative Direct
Molecular Function (MF) receptor binding 0 Informative Direct
Molecular Function (MF) protein complex binding 5.192e-11 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.9956 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) vesicle 1.299e-05 Moderately Informative Direct
Cellular Component (CC) extracellular region part 1.262e-11 Moderately Informative Direct
Cellular Component (CC) ribonucleoprotein complex 0.00283 Moderately Informative Inherited
Cellular Component (CC) extracellular space 4.78e-06 Informative Direct
Cellular Component (CC) secretory granule 6.088e-15 Informative Direct
Cellular Component (CC) small nucleolar ribonucleoprotein complex 1.794e-12 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0Least InformativeDirect
Disease Ontology (DO)nervous system disease0.243Least InformativeInherited
Disease Ontology (DO)cell type cancer0Moderately InformativeDirect
Disease Ontology (DO)artery disease0Moderately InformativeDirect
Disease Ontology (DO)endocrine system disease0.000149Moderately InformativeDirect
Disease Ontology (DO)disease of metabolism0.001825Moderately InformativeInherited
Disease Ontology (DO)syndrome0.005695Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.008521Moderately InformativeInherited
Disease Ontology (DO)hypertension0InformativeDirect
Disease Ontology (DO)overnutrition7.577e-06InformativeDirect
Disease Ontology (DO)in situ carcinoma3.527e-05InformativeDirect
Disease Ontology (DO)motor neuron disease4.867e-05InformativeDirect
Disease Ontology (DO)liver disease0.002624InformativeInherited
Disease Ontology (DO)pancreas disease0.1224InformativeInherited
Disease Ontology (DO)hyperandrogenism4.034e-08Highly InformativeDirect
Disease Ontology (DO)interstitial lung disease4.752e-05Highly InformativeDirect
Disease Ontology (DO)synucleinopathy5.319e-05Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.04876Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body phenotype0.1998Least InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal skeleton morphology0.008198Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.1709Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal male germ cell morphology0.0009429InformativeDirect
Mammalian Phenotype (MP)abnormal prenatal growth/weight/body size0.01807InformativeInherited
Mammalian Phenotype (MP)abnormal circulating glucose level0.02258InformativeInherited
Mammalian Phenotype (MP)abnormal sex determination0.1016InformativeInherited
Mammalian Phenotype (MP)abnormal pancreas morphology0.1268InformativeInherited
Mammalian Phenotype (MP)abnormal bone structure0.2322InformativeInherited
Mammalian Phenotype (MP)decreased birth weight1.508e-06Highly InformativeDirect
Mammalian Phenotype (MP)decreased fetal size0.0005501Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pancreatic islet morphology0.0008471Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.0002272Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.05851Least InformativeInherited
Worm Phenotype (WP)locomotion variant1.298e-05Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant9.153e-05Moderately InformativeDirect
Worm Phenotype (WP)lipid metabolism variant0.0003172InformativeDirect
Worm Phenotype (WP)body length variant0.0004554InformativeDirect
Worm Phenotype (WP)body width variant0.0006215InformativeDirect
Worm Phenotype (WP)dauer development variant1.519e-10Highly InformativeDirect
Worm Phenotype (WP)dauer arrest variant8.647e-10Highly InformativeDirect
Worm Phenotype (WP)small2.592e-06Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)mating defective0.0001282Highly InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)alimentary system0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus DEvelopment stage (XDE)embryonic stage0Least InformativeDirect
Xenopus DEvelopment stage (XDE)NF stage0Least InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processGlucose metabolism0Highly InformativeDirect
Biological processOsteogenesis0Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
DomainSignal0Least InformativeDirect
Post-translational modificationGrowth factor0InformativeDirect
Post-translational modificationHormone0Highly InformativeDirect
Post-translational modificationMitogen0Highly InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues0Moderately InformativeDirect
Post-translational modificationPyrrolidone carboxylic acid0InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 11 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Insulin-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 11 hidden Markov models representing the Insulin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]