SUPERFAMILY 1.75 HMM library and genome assignments server

Insulin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Insulin-like [ 56993]
Superfamily:   Insulin-like [ 56994]
Families:   Insulin-like [ 56995] (4)


Superfamily statistics
Genomes (136) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 959 1,683 48
Proteins 954 1,680 48


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)developmental process0.00000031720.000000001485Least InformativeDirect
Biological Process (BP)response to stimulus0.000030310.0009063Least InformativeDirect
Biological Process (BP)regulation of metabolic process0.28330.4308Least InformativeInherited
Biological Process (BP)regulation of cellular process0.13890.006572Least InformativeInherited
Biological Process (BP)localization0.0025170.753Least InformativeInherited
Biological Process (BP)positive regulation of biological process0.19040.01216Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.40920.9288Least InformativeInherited
Biological Process (BP)single-organism cellular process0.62440.902Least InformativeInherited
Biological Process (BP)response to endogenous stimulus0.00000026370.0000000777Moderately InformativeDirect
Biological Process (BP)positive regulation of metabolic process0.0000000013020.000000000001077Moderately InformativeDirect
Biological Process (BP)regulation of signal transduction0.00086680.00000007283Moderately InformativeDirect
Biological Process (BP)response to organic substance0.00000000059370.0000000507Moderately InformativeDirect
Biological Process (BP)regulation of macromolecule biosynthetic process0.00000000012970.00001747Moderately InformativeDirect
Biological Process (BP)cell differentiation0.000011170.000002621Moderately InformativeDirect
Biological Process (BP)regulation of cellular biosynthetic process0.00000000037590Moderately InformativeDirect
Biological Process (BP)positive regulation of molecular function0.000000040250.00001396Moderately InformativeDirect
Biological Process (BP)response to oxygen-containing compound0.000000000013840.00000000001945Moderately InformativeDirect
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.0031640.9125Moderately InformativeInherited
Biological Process (BP)regulation of catalytic activity0.0097190.4225Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.053980.004228Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.0054060.00005214Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.0077940.004586Moderately InformativeInherited
Biological Process (BP)carbohydrate metabolic process0.000017480.01946Moderately InformativeInherited
Biological Process (BP)lipid metabolic process0.000053340.03141Moderately InformativeInherited
Biological Process (BP)single-organism catabolic process0.00018230.06389Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.0011280.273Moderately InformativeInherited
Biological Process (BP)organic substance transport0.00000036050.005153Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.00027370.01668Moderately InformativeInherited
Biological Process (BP)signal transduction0.020790.005764Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.039290.07949Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.011070.9564Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.00021160.3019Moderately InformativeInherited
Biological Process (BP)regulation of phosphorus metabolic process0.0014920.0007765Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.023460.1434Moderately InformativeInherited
Biological Process (BP)regulation of protein phosphorylation0.000000000021880InformativeDirect
Biological Process (BP)apoptotic process0.00000002190.000000000003005InformativeDirect
Biological Process (BP)enzyme linked receptor protein signaling pathway00.000000000159InformativeDirect
Biological Process (BP)response to organonitrogen compound0.00000086420.0000000008213InformativeDirect
Biological Process (BP)lipid catabolic process0.0000000011640.000001591InformativeDirect
Biological Process (BP)regulation of lipid metabolic process0.000000092570.00001701InformativeDirect
Biological Process (BP)hexose metabolic process0.0000000026310.000006867InformativeDirect
Biological Process (BP)cellular response to hormone stimulus0.0000062260.00000003748InformativeDirect
Biological Process (BP)regulation of apoptotic process0.00016880InformativeDirect
Biological Process (BP)regulation of MAPK cascade0.00022160.0003414InformativeDirect
Biological Process (BP)regulation of transferase activity0.00000000013520.000000173InformativeDirect
Biological Process (BP)muscle structure development0.00000030650.0001275InformativeDirect
Biological Process (BP)cellular response to nitrogen compound0.000000019620.00000000001267InformativeDirect
Biological Process (BP)cellular response to oxygen-containing compound0.00023350.000001357InformativeDirect
Biological Process (BP)positive regulation of phosphate metabolic process0.00000000029980.7274InformativeInherited
Biological Process (BP)positive regulation of cellular protein metabolic process0.00014110.1132InformativeInherited
Biological Process (BP)negative regulation of cell death0.17860InformativeInherited
Biological Process (BP)positive regulation of intracellular signal transduction0.010070.002841InformativeInherited
Biological Process (BP)intracellular signal transduction0.0043940.8166InformativeInherited
Biological Process (BP)anatomical structure formation involved in morphogenesis0.0011850.3867InformativeInherited
Biological Process (BP)phosphorylation0.000000080570.007456InformativeInherited
Biological Process (BP)MAPK cascade0.0000000000018110.0000188Highly InformativeDirect
Biological Process (BP)glucose metabolic process0.00000000060190.000002186Highly InformativeDirect
Biological Process (BP)ER-nucleus signaling pathway0.0000000029190.0001394Highly InformativeDirect
Biological Process (BP)transmembrane receptor protein tyrosine kinase signaling pathway00Highly InformativeDirect
Biological Process (BP)carbohydrate transport00.00000000001516Highly InformativeDirect
Biological Process (BP)stress-activated protein kinase signaling cascade0.00000000016710.000000003109Highly InformativeDirect
Biological Process (BP)response to endoplasmic reticulum stress0.0000000000071380.0000006344Highly InformativeDirect
Biological Process (BP)response to peptide hormone00.00000002296Highly InformativeDirect
Biological Process (BP)positive regulation of lipid metabolic process0.0000000068570.0000002459Highly InformativeDirect
Biological Process (BP)regulation of peptidyl-tyrosine phosphorylation00.00002957Highly InformativeDirect
Biological Process (BP)regulation of binding0.000000082850.000002176Highly InformativeDirect
Biological Process (BP)cellular response to biotic stimulus0.00000000053790.000004385Highly InformativeDirect
Biological Process (BP)regulation of cellular response to insulin stimulus0.00000000092350.00000001085Highly InformativeDirect
Biological Process (BP)cellular response to peptide0.000000081730.00000000002117Highly InformativeDirect
Biological Process (BP)intrinsic apoptotic signaling pathway0.000003950.001538Highly InformativeInherited
Biological Process (BP)regulation of cellular response to stress0.00000074370.01331Highly InformativeInherited
Biological Process (BP)positive regulation of MAPK cascade0.00037790.1858Highly InformativeInherited
Biological Process (BP)regulation of protein serine/threonine kinase activity0.057410.01771Highly InformativeInherited
Biological Process (BP)positive regulation of protein kinase activity0.0028370.03332Highly InformativeInherited
Molecular Function (MF)binding0.00059790.0000000008403Least InformativeDirect
Molecular Function (MF)receptor binding0.0000000031330InformativeDirect
Molecular Function (MF)protein complex binding0.0000012180.000001725InformativeDirect
Cellular Component (CC)cytoplasmic part0.0073730.9956Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.28371Least InformativeInherited
Cellular Component (CC)vesicle0.0000000006940.00001422Moderately InformativeDirect
Cellular Component (CC)extracellular region part0.00080670.00000000001296Moderately InformativeDirect
Cellular Component (CC)ribonucleoprotein complex0.00000064020.002824Moderately InformativeInherited
Cellular Component (CC)extracellular space0.000059340.000004587InformativeDirect
Cellular Component (CC)secretory granule00.000000000000006018InformativeDirect
Cellular Component (CC)small nucleolar ribonucleoprotein complex0.0000000000000081390.000000000001761Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0.0000000007788 Least Informative Direct
Biological Process (BP) developmental process 0.000000001485 Least Informative Direct
Biological Process (BP) response to stimulus 0.0009063 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.4308 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.006572 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.2589 Least Informative Inherited
Biological Process (BP) positive regulation of biological process 0.01216 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.8269 Least Informative Inherited
Biological Process (BP) localization 0.753 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.902 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.7262 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.9288 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.4945 Least Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.00003476 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0.0000000777 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0.000000000001077 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.00000007283 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.0000000507 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0.00001747 Moderately Informative Direct
Biological Process (BP) reproductive process 0.00000000001092 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.000002621 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 0.00001396 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.00005214 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.000112 Moderately Informative Direct
Biological Process (BP) regulation of phosphorus metabolic process 0.0007765 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.00000000001945 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.004228 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.4225 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.5076 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.1434 Moderately Informative Inherited
Biological Process (BP) tissue development 0.7512 Moderately Informative Inherited
Biological Process (BP) organ development 0.2411 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.04362 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.9274 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.004586 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.9087 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.8635 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.01946 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.03141 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.06389 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.273 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.005153 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.07949 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.008147 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.01352 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.007073 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.01668 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.005764 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.9564 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.3019 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.9125 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.003067 Moderately Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.0003349 Informative Direct
Biological Process (BP) apoptotic process 0.000000000003005 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.000000000159 Informative Direct
Biological Process (BP) response to organonitrogen compound 0.0000000008213 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.0000009433 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.000000000008942 Informative Direct
Biological Process (BP) lipid catabolic process 0.000001591 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 0.00001701 Informative Direct
Biological Process (BP) hexose metabolic process 0.000006867 Informative Direct
Biological Process (BP) negative regulation of signaling 0.000000000003463 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0.00000001278 Informative Direct
Biological Process (BP) cellular response to hormone stimulus 0.00000003748 Informative Direct
Biological Process (BP) regulation of organelle organization 0.0000000009075 Informative Direct
Biological Process (BP) growth 0.00000003595 Informative Direct
Biological Process (BP) regulation of apoptotic process 0 Informative Direct
Biological Process (BP) regulation of MAPK cascade 0.0003414 Informative Direct
Biological Process (BP) sulfur compound biosynthetic process 0.0000004921 Informative Direct
Biological Process (BP) single organism reproductive process 0.000005197 Informative Direct
Biological Process (BP) multi-multicellular organism process 0.0001516 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.000000000004816 Informative Direct
Biological Process (BP) reproductive structure development 0.00001744 Informative Direct
Biological Process (BP) gland development 0.00004714 Informative Direct
Biological Process (BP) positive regulation of transport 0.000002177 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.00000000002107 Informative Direct
Biological Process (BP) regulation of transferase activity 0.000000173 Informative Direct
Biological Process (BP) regulation of nervous system development 0.0001721 Informative Direct
Biological Process (BP) negative regulation of cell death 0 Informative Direct
Biological Process (BP) muscle structure development 0.0001275 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 0.00000000001267 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.000001357 Informative Direct
Biological Process (BP) organ morphogenesis 0.1014 Informative Inherited
Biological Process (BP) epithelium development 0.0562 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.1091 Informative Inherited
Biological Process (BP) cardiovascular system development 0.1027 Informative Inherited
Biological Process (BP) positive regulation of intracellular signal transduction 0.002841 Informative Inherited
Biological Process (BP) sensory organ development 0.05184 Informative Inherited
Biological Process (BP) tube development 0.1023 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.7274 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 0.1132 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.04276 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.03561 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.02293 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.8166 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.3867 Informative Inherited
Biological Process (BP) phosphorylation 0.007456 Informative Inherited
Biological Process (BP) MAPK cascade 0.0000188 Highly Informative Direct
Biological Process (BP) glucose metabolic process 0.000002186 Highly Informative Direct
Biological Process (BP) aminoglycan biosynthetic process 0.00000000003429 Highly Informative Direct
Biological Process (BP) ER-nucleus signaling pathway 0.0001394 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0 Highly Informative Direct
Biological Process (BP) carbohydrate transport 0.00000000001516 Highly Informative Direct
Biological Process (BP) glial cell differentiation 0.000003762 Highly Informative Direct
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of mitochondrion organization 0 Highly Informative Direct
Biological Process (BP) glycosaminoglycan metabolic process 0.000000000541 Highly Informative Direct
Biological Process (BP) respiratory tube development 0.00001911 Highly Informative Direct
Biological Process (BP) stress-activated protein kinase signaling cascade 0.000000003109 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0.0000006344 Highly Informative Direct
Biological Process (BP) wound healing 0.0001405 Highly Informative Direct
Biological Process (BP) response to peptide hormone 0.00000002296 Highly Informative Direct
Biological Process (BP) ear development 0.0003408 Highly Informative Direct
Biological Process (BP) positive regulation of lipid metabolic process 0.0000002459 Highly Informative Direct
Biological Process (BP) regulation of glucose import 0 Highly Informative Direct
Biological Process (BP) developmental growth 0.0000002412 Highly Informative Direct
Biological Process (BP) branching morphogenesis of an epithelial tube 0.00000002958 Highly Informative Direct
Biological Process (BP) regulation of peptidyl-tyrosine phosphorylation 0.00002957 Highly Informative Direct
Biological Process (BP) regulation of binding 0.000002176 Highly Informative Direct
Biological Process (BP) respiratory system development 0.0003425 Highly Informative Direct
Biological Process (BP) connective tissue development 0.000002695 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0.000004385 Highly Informative Direct
Biological Process (BP) extrinsic apoptotic signaling pathway 0.000005209 Highly Informative Direct
Biological Process (BP) regulation of cellular response to insulin stimulus 0.00000001085 Highly Informative Direct
Biological Process (BP) cellular response to peptide 0.00000000002117 Highly Informative Direct
Biological Process (BP) regulation of neural precursor cell proliferation 0.000002948 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic signaling pathway 0.000000000000003707 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular signal transduction 0.5614 Highly Informative Inherited
Biological Process (BP) intrinsic apoptotic signaling pathway 0.001538 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.01331 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 0.1858 Highly Informative Inherited
Biological Process (BP) regulation of protein serine/threonine kinase activity 0.01771 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 0.03332 Highly Informative Inherited
Molecular Function (MF) binding 0.0000000008403 Least Informative Direct
Molecular Function (MF) receptor binding 0 Informative Direct
Molecular Function (MF) protein complex binding 0.000001725 Informative Direct
Cellular Component (CC) cytoplasmic part 0.9956 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) vesicle 0.00001422 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.00000000001296 Moderately Informative Direct
Cellular Component (CC) ribonucleoprotein complex 0.002824 Moderately Informative Inherited
Cellular Component (CC) extracellular space 0.000004587 Informative Direct
Cellular Component (CC) secretory granule 0.000000000000006018 Informative Direct
Cellular Component (CC) small nucleolar ribonucleoprotein complex 0.000000000001761 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0Least InformativeDirect
Disease Ontology (DO)nervous system disease0.243Least InformativeInherited
Disease Ontology (DO)cell type cancer0Moderately InformativeDirect
Disease Ontology (DO)artery disease0Moderately InformativeDirect
Disease Ontology (DO)endocrine system disease0.000149Moderately InformativeDirect
Disease Ontology (DO)disease of metabolism0.001825Moderately InformativeInherited
Disease Ontology (DO)syndrome0.005695Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.008521Moderately InformativeInherited
Disease Ontology (DO)hypertension0InformativeDirect
Disease Ontology (DO)overnutrition0.000007577InformativeDirect
Disease Ontology (DO)in situ carcinoma0.00003527InformativeDirect
Disease Ontology (DO)motor neuron disease0.00004867InformativeDirect
Disease Ontology (DO)liver disease0.002624InformativeInherited
Disease Ontology (DO)pancreas disease0.1224InformativeInherited
Disease Ontology (DO)hyperandrogenism0.00000004034Highly InformativeDirect
Disease Ontology (DO)interstitial lung disease0.00004752Highly InformativeDirect
Disease Ontology (DO)synucleinopathy0.00005319Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.04876Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body phenotype0.1998Least InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal skeleton morphology0.008198Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.1709Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal male germ cell morphology0.0009429InformativeDirect
Mammalian Phenotype (MP)abnormal prenatal growth/weight/body size0.01807InformativeInherited
Mammalian Phenotype (MP)abnormal circulating glucose level0.02258InformativeInherited
Mammalian Phenotype (MP)abnormal sex determination0.1016InformativeInherited
Mammalian Phenotype (MP)abnormal pancreas morphology0.1268InformativeInherited
Mammalian Phenotype (MP)abnormal bone structure0.2322InformativeInherited
Mammalian Phenotype (MP)decreased birth weight0.000001508Highly InformativeDirect
Mammalian Phenotype (MP)decreased fetal size0.0005501Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pancreatic islet morphology0.0008471Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.0002272Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.05851Least InformativeInherited
Worm Phenotype (WP)locomotion variant0.00001298Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.00009153Moderately InformativeDirect
Worm Phenotype (WP)lipid metabolism variant0.0003172InformativeDirect
Worm Phenotype (WP)body length variant0.0004554InformativeDirect
Worm Phenotype (WP)body width variant0.0006215InformativeDirect
Worm Phenotype (WP)dauer development variant0.0000000001519Highly InformativeDirect
Worm Phenotype (WP)dauer arrest variant0.0000000008647Highly InformativeDirect
Worm Phenotype (WP)small0.000002592Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)mating defective0.0001282Highly InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)alimentary system0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus DEvelopment stage (XDE)embryonic stage0Least InformativeDirect
Xenopus DEvelopment stage (XDE)NF stage0Least InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processGlucose metabolism0Highly InformativeDirect
Biological processOsteogenesis0Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
DomainSignal0Least InformativeDirect
Post-translational modificationGrowth factor0InformativeDirect
Post-translational modificationHormone0Highly InformativeDirect
Post-translational modificationMitogen0Highly InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues0Moderately InformativeDirect
Post-translational modificationPyrrolidone carboxylic acid0InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 11 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Insulin-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 11 hidden Markov models representing the Insulin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]