SUPERFAMILY 1.75 HMM library and genome assignments server


Insulin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Insulin-like [ 56993]
Superfamily:   Insulin-like [ 56994]
Families:   Insulin-like [ 56995] (4)


Superfamily statistics
Genomes (136) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 959 1,683 48
Proteins 954 1,680 48


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process2.014e-082.301e-13Least InformativeDirect
Biological Process (BP)developmental process2.927e-071.178e-09Least InformativeDirect
Biological Process (BP)response to stimulus2.671e-050.000666Least InformativeDirect
Biological Process (BP)regulation of cellular process0.098280.004579Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.23590.3298Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.015840.03541Least InformativeInherited
Biological Process (BP)localization0.0019350.6921Least InformativeInherited
Biological Process (BP)single-organism cellular process0.14350.2515Least InformativeInherited
Biological Process (BP)response to endogenous stimulus2.449e-076.898e-08Moderately InformativeDirect
Biological Process (BP)regulation of biosynthetic process4.264e-100Moderately InformativeDirect
Biological Process (BP)positive regulation of metabolic process3.911e-110Moderately InformativeDirect
Biological Process (BP)regulation of signal transduction0.00084257.04e-08Moderately InformativeDirect
Biological Process (BP)response to organic substance4.533e-103.395e-08Moderately InformativeDirect
Biological Process (BP)cell differentiation9.926e-061.913e-06Moderately InformativeDirect
Biological Process (BP)regulation of programmed cell death0.00023450Moderately InformativeDirect
Biological Process (BP)positive regulation of molecular function4.108e-081.113e-05Moderately InformativeDirect
Biological Process (BP)response to oxygen-containing compound1.105e-111.207e-11Moderately InformativeDirect
Biological Process (BP)cellular response to chemical stimulus0.00026380.01531Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.0023370.001184Moderately InformativeInherited
Biological Process (BP)regulation of catalytic activity0.013530.4601Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process18.818e-13Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.010860.9393Moderately InformativeInherited
Biological Process (BP)carbohydrate metabolic process1.432e-050.01751Moderately InformativeInherited
Biological Process (BP)tissue development0.01680.103Moderately InformativeInherited
Biological Process (BP)organic substance transport3.212e-070.00468Moderately InformativeInherited
Biological Process (BP)organ development0.00550.00247Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.035580.05644Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.03330.000972Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.02330.1443Moderately InformativeInherited
Biological Process (BP)signal transduction0.02550.006662Moderately InformativeInherited
Biological Process (BP)regulation of protein phosphorylation1.54e-110InformativeDirect
Biological Process (BP)apoptotic process2.191e-082.526e-12InformativeDirect
Biological Process (BP)enzyme linked receptor protein signaling pathway01.542e-10InformativeDirect
Biological Process (BP)response to hormone stimulus5.639e-052.932e-09InformativeDirect
Biological Process (BP)response to organonitrogen compound1.012e-069.624e-10InformativeDirect
Biological Process (BP)lipid catabolic process1.011e-091.398e-06InformativeDirect
Biological Process (BP)regulation of lipid metabolic process2.258e-072.442e-05InformativeDirect
Biological Process (BP)hexose metabolic process7.947e-091.609e-05InformativeDirect
Biological Process (BP)single-organism behavior0.00013138.113e-05InformativeDirect
Biological Process (BP)muscle structure development2.968e-070.000369InformativeDirect
Biological Process (BP)cellular response to nitrogen compound2.028e-081.318e-11InformativeDirect
Biological Process (BP)cellular response to oxygen-containing compound0.00022611.253e-06InformativeDirect
Biological Process (BP)cellular response to endogenous stimulus0.0055710.01232InformativeInherited
Biological Process (BP)muscle tissue development1.393e-110.01009InformativeInherited
Biological Process (BP)regulation of intracellular protein kinase cascade0.087520.5879InformativeInherited
Biological Process (BP)regulation of kinase activity0.035751InformativeInherited
Biological Process (BP)positive regulation of signal transduction0.036320.2925InformativeInherited
Biological Process (BP)positive regulation of protein modification process2.201e-120.3087InformativeInherited
Biological Process (BP)positive regulation of phosphate metabolic process2.144e-120.03118InformativeInherited
Biological Process (BP)intracellular signal transduction0.0038350.7526InformativeInherited
Biological Process (BP)anatomical structure formation involved in morphogenesis0.0011250.3746InformativeInherited
Biological Process (BP)MAPK cascade1.65e-121.394e-07Highly InformativeDirect
Biological Process (BP)ER-nucleus signaling pathway2.989e-090.00014Highly InformativeDirect
Biological Process (BP)transmembrane receptor protein tyrosine kinase signaling pathway00Highly InformativeDirect
Biological Process (BP)carbohydrate transport01.46e-11Highly InformativeDirect
Biological Process (BP)stress-activated protein kinase signaling cascade7.483e-103.273e-09Highly InformativeDirect
Biological Process (BP)response to endoplasmic reticulum stress6.7e-124.606e-07Highly InformativeDirect
Biological Process (BP)response to peptide hormone stimulus02.164e-08Highly InformativeDirect
Biological Process (BP)positive regulation of lipid metabolic process7.947e-081.642e-06Highly InformativeDirect
Biological Process (BP)regulation of binding4.928e-081.494e-06Highly InformativeDirect
Biological Process (BP)cellular response to biotic stimulus3.939e-103.758e-06Highly InformativeDirect
Biological Process (BP)regulation of cellular response to insulin stimulus9.112e-108.161e-09Highly InformativeDirect
Biological Process (BP)cellular response to peptide8.828e-082.264e-11Highly InformativeDirect
Biological Process (BP)intrinsic apoptotic signaling pathway4.571e-060.001978Highly InformativeInherited
Biological Process (BP)regulation of cellular response to stress5.879e-070.01118Highly InformativeInherited
Biological Process (BP)muscle organ development1.326e-060.01709Highly InformativeInherited
Biological Process (BP)regulation of MAP kinase activity0.0010090.6788Highly InformativeInherited
Biological Process (BP)positive regulation of MAPK cascade2.011e-120.4737Highly InformativeInherited
Biological Process (BP)positive regulation of protein kinase activity0.0032390.03882Highly InformativeInherited
Molecular Function (MF)binding0.00045273.112e-10Least InformativeDirect
Molecular Function (MF)receptor binding3.268e-090InformativeDirect
Molecular Function (MF)protein complex binding3.435e-094.995e-11Highly InformativeDirect
Cellular Component (CC)cytoplasmic part0.0073070.9806Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.33381Least InformativeInherited
Cellular Component (CC)vesicle6.564e-101.149e-05Moderately InformativeDirect
Cellular Component (CC)extracellular region part0.00079391.043e-11Moderately InformativeDirect
Cellular Component (CC)ribonucleoprotein complex6.129e-070.002684Moderately InformativeInherited
Cellular Component (CC)extracellular space5.747e-054.684e-06InformativeDirect
Cellular Component (CC)secretory granule06.169e-15InformativeDirect
Cellular Component (CC)small nucleolar ribonucleoprotein complex8.424e-151.841e-12Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 2.301e-13 Least Informative Direct
Biological Process (BP) developmental process 1.178e-09 Least Informative Direct
Biological Process (BP) response to stimulus 0.000666 Least Informative Direct
Biological Process (BP) biosynthetic process 0.4639 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.004579 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.3298 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.03541 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.6791 Least Informative Inherited
Biological Process (BP) localization 0.6921 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.2515 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.2333 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.8046 Least Informative Inherited
Biological Process (BP) reproduction 1.542e-10 Moderately Informative Direct
Biological Process (BP) sulfur compound metabolic process 9.244e-06 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 6.898e-08 Moderately Informative Direct
Biological Process (BP) regulation of biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 7.04e-08 Moderately Informative Direct
Biological Process (BP) response to organic substance 3.395e-08 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 8.818e-13 Moderately Informative Direct
Biological Process (BP) cell differentiation 1.913e-06 Moderately Informative Direct
Biological Process (BP) regulation of programmed cell death 0 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 1.113e-05 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.000972 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 2.167e-05 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 5.282e-05 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 1.207e-11 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.01531 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.006662 Moderately Informative Inherited
Biological Process (BP) tissue development 0.103 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.1443 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.8982 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.004845 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.01226 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.002516 Moderately Informative Inherited
Biological Process (BP) organ development 0.00247 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.006452 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.1001 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.001184 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.4601 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.9393 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.008358 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.9475 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.01751 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.05644 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.00468 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.0002735 Informative Direct
Biological Process (BP) apoptotic process 2.526e-12 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 1.542e-10 Informative Direct
Biological Process (BP) response to hormone stimulus 2.932e-09 Informative Direct
Biological Process (BP) response to organonitrogen compound 9.624e-10 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1.454e-06 Informative Direct
Biological Process (BP) lipid catabolic process 1.398e-06 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 2.442e-05 Informative Direct
Biological Process (BP) hexose metabolic process 1.609e-05 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 1.712e-07 Informative Direct
Biological Process (BP) regulation of organelle organization 1.967e-10 Informative Direct
Biological Process (BP) growth 2.639e-08 Informative Direct
Biological Process (BP) sulfur compound biosynthetic process 1.642e-07 Informative Direct
Biological Process (BP) multi-multicellular organism process 0.000322 Informative Direct
Biological Process (BP) single-organism behavior 8.113e-05 Informative Direct
Biological Process (BP) gland development 4.725e-06 Informative Direct
Biological Process (BP) positive regulation of transport 2.756e-06 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 9.582e-12 Informative Direct
Biological Process (BP) regulation of nervous system development 0.0001518 Informative Direct
Biological Process (BP) negative regulation of cell death 0 Informative Direct
Biological Process (BP) muscle structure development 0.000369 Informative Direct
Biological Process (BP) reproductive system development 1.425e-05 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 1.318e-11 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 1.253e-06 Informative Direct
Biological Process (BP) regulation of apoptotic signaling pathway 5.353e-11 Informative Direct
Biological Process (BP) positive regulation of cell proliferation 0.006649 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.02271 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.01488 Informative Inherited
Biological Process (BP) organ morphogenesis 0.1337 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.004786 Informative Inherited
Biological Process (BP) epithelium development 0.7328 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.1327 Informative Inherited
Biological Process (BP) cardiovascular system development 0.2302 Informative Inherited
Biological Process (BP) tube development 0.0397 Informative Inherited
Biological Process (BP) sensory organ development 0.06674 Informative Inherited
Biological Process (BP) response to wounding 0.01829 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.01104 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.01232 Informative Inherited
Biological Process (BP) muscle tissue development 0.01009 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.2925 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.5879 Informative Inherited
Biological Process (BP) regulation of kinase activity 1 Informative Inherited
Biological Process (BP) positive regulation of protein modification process 0.3087 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.03118 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.7526 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.3746 Informative Inherited
Biological Process (BP) MAPK cascade 1.394e-07 Highly Informative Direct
Biological Process (BP) aminoglycan biosynthetic process 2.244e-11 Highly Informative Direct
Biological Process (BP) ER-nucleus signaling pathway 0.00014 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0 Highly Informative Direct
Biological Process (BP) carbohydrate transport 1.46e-11 Highly Informative Direct
Biological Process (BP) glial cell differentiation 4.298e-06 Highly Informative Direct
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of mitochondrion organization 0 Highly Informative Direct
Biological Process (BP) glycosaminoglycan metabolic process 3.71e-10 Highly Informative Direct
Biological Process (BP) respiratory tube development 2.581e-05 Highly Informative Direct
Biological Process (BP) stress-activated protein kinase signaling cascade 3.273e-09 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 4.606e-07 Highly Informative Direct
Biological Process (BP) wound healing 0.000126 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic process 1.718e-09 Highly Informative Direct
Biological Process (BP) response to peptide hormone stimulus 2.164e-08 Highly Informative Direct
Biological Process (BP) ear development 0.0003354 Highly Informative Direct
Biological Process (BP) positive regulation of lipid metabolic process 1.642e-06 Highly Informative Direct
Biological Process (BP) regulation of glucose import 0 Highly Informative Direct
Biological Process (BP) developmental growth 4.732e-07 Highly Informative Direct
Biological Process (BP) branching morphogenesis of an epithelial tube 3.024e-08 Highly Informative Direct
Biological Process (BP) regulation of binding 1.494e-06 Highly Informative Direct
Biological Process (BP) regulation of protein kinase B signaling cascade 4.081e-05 Highly Informative Direct
Biological Process (BP) connective tissue development 9.619e-05 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 3.758e-06 Highly Informative Direct
Biological Process (BP) extrinsic apoptotic signaling pathway 5.024e-06 Highly Informative Direct
Biological Process (BP) regulation of cellular response to insulin stimulus 8.161e-09 Highly Informative Direct
Biological Process (BP) cellular response to peptide 2.264e-11 Highly Informative Direct
Biological Process (BP) regulation of neural precursor cell proliferation 2.714e-06 Highly Informative Direct
Biological Process (BP) intrinsic apoptotic signaling pathway 0.001978 Highly Informative Inherited
Biological Process (BP) respiratory system development 0.001292 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.01118 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.01709 Highly Informative Inherited
Biological Process (BP) regulation of MAP kinase activity 0.6788 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 0.4737 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 0.03882 Highly Informative Inherited
Molecular Function (MF) binding 3.112e-10 Least Informative Direct
Molecular Function (MF) receptor binding 0 Informative Direct
Molecular Function (MF) protein complex binding 4.995e-11 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.9806 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) vesicle 1.149e-05 Moderately Informative Direct
Cellular Component (CC) extracellular region part 1.043e-11 Moderately Informative Direct
Cellular Component (CC) ribonucleoprotein complex 0.002684 Moderately Informative Inherited
Cellular Component (CC) extracellular space 4.684e-06 Informative Direct
Cellular Component (CC) secretory granule 6.169e-15 Informative Direct
Cellular Component (CC) small nucleolar ribonucleoprotein complex 1.841e-12 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0Least InformativeDirect
Disease Ontology (DO)nervous system disease0.3704Least InformativeInherited
Disease Ontology (DO)cell type cancer0Moderately InformativeDirect
Disease Ontology (DO)artery disease0Moderately InformativeDirect
Disease Ontology (DO)disease of metabolism0.0004325Moderately InformativeDirect
Disease Ontology (DO)endocrine system disease0.0006336Moderately InformativeDirect
Disease Ontology (DO)lung disease0.006707Moderately InformativeInherited
Disease Ontology (DO)syndrome0.01885Moderately InformativeInherited
Disease Ontology (DO)central nervous system disease0.02388Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.1191Moderately InformativeInherited
Disease Ontology (DO)hypertension0InformativeDirect
Disease Ontology (DO)overnutrition3.436e-05InformativeDirect
Disease Ontology (DO)in situ carcinoma9.194e-05InformativeDirect
Disease Ontology (DO)motor neuron disease0.0001252InformativeDirect
Disease Ontology (DO)endocrine gland cancer0.001885InformativeInherited
Disease Ontology (DO)liver disease0.005729InformativeInherited
Disease Ontology (DO)pancreas disease0.1205InformativeInherited
Disease Ontology (DO)hyperandrogenism1.144e-07Highly InformativeDirect
Disease Ontology (DO)polycystic ovary syndrome9.762e-07Highly InformativeDirect
Disease Ontology (DO)interstitial lung disease0.0001143Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.04785Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body phenotype0.1995Least InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal skeleton morphology0.007838Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.173Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal male germ cell morphology0.000971InformativeDirect
Mammalian Phenotype (MP)abnormal bone mineral density0.001826InformativeInherited
Mammalian Phenotype (MP)abnormal prenatal growth/weight/body size0.01795InformativeInherited
Mammalian Phenotype (MP)abnormal circulating glucose level0.02177InformativeInherited
Mammalian Phenotype (MP)abnormal sex determination0.1006InformativeInherited
Mammalian Phenotype (MP)abnormal pancreas morphology0.1185InformativeInherited
Mammalian Phenotype (MP)decreased birth weight1.533e-06Highly InformativeDirect
Mammalian Phenotype (MP)decreased fetal size0.0005616Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pancreatic islet morphology0.0007551Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.0002272Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.05851Least InformativeInherited
Worm Phenotype (WP)locomotion variant1.298e-05Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant9.153e-05Moderately InformativeDirect
Worm Phenotype (WP)lipid metabolism variant0.0003172InformativeDirect
Worm Phenotype (WP)body length variant0.0004554InformativeDirect
Worm Phenotype (WP)body width variant0.0006215InformativeDirect
Worm Phenotype (WP)dauer development variant1.519e-10Highly InformativeDirect
Worm Phenotype (WP)dauer arrest variant8.647e-10Highly InformativeDirect
Worm Phenotype (WP)small2.592e-06Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)mating defective0.00011Highly InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)alimentary system0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus DEvelopment stage (XDE)embryonic stage0Least InformativeDirect
Xenopus DEvelopment stage (XDE)NF stage0Least InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processGlucose metabolism0Highly InformativeDirect
Biological processOsteogenesis0Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
DomainSignal0Least InformativeDirect
Post-translational modificationGrowth factor0InformativeDirect
Post-translational modificationHormone0Highly InformativeDirect
Post-translational modificationMitogen0Highly InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues0Moderately InformativeDirect
Post-translational modificationPyrrolidone carboxylic acid0InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 11 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Insulin-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 11 hidden Markov models representing the Insulin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]