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Insulin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Insulin-like [ 56993]
Superfamily:   Insulin-like [ 56994]
Families:   Insulin-like [ 56995] (4)

Superfamily statistics
Genomes (120) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 876 1,498 48
Proteins 872 1,495 48

 Functional annotation
General category Regulation
Detailed category Signal transduction

Document: Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process1.441e-081.182e-12Least InformativeDirect
Biological Process (BP)developmental process2.151e-073.905e-09Least InformativeDirect
Biological Process (BP)regulation of cellular process2.044e-110Least InformativeDirect
Biological Process (BP)single-organism cellular process0.033380.003859Least InformativeInherited
Biological Process (BP)response to stimulus0.00016450.003286Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.13450.1831Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.017260.03574Least InformativeInherited
Biological Process (BP)localization0.0023030.771Least InformativeInherited
Biological Process (BP)protein metabolic process0.0008140.008907Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.0042080.1826Least InformativeInherited
Biological Process (BP)response to endogenous stimulus3.723e-081.958e-08Moderately InformativeDirect
Biological Process (BP)regulation of biosynthetic process3.403e-100Moderately InformativeDirect
Biological Process (BP)positive regulation of metabolic process2.102e-110Moderately InformativeDirect
Biological Process (BP)response to organic substance3.199e-106.589e-08Moderately InformativeDirect
Biological Process (BP)regulation of cell communication7.88e-070Moderately InformativeDirect
Biological Process (BP)regulation of signaling1.042e-070Moderately InformativeDirect
Biological Process (BP)cell differentiation6.245e-063.029e-06Moderately InformativeDirect
Biological Process (BP)regulation of response to stimulus2.092e-054.008e-15Moderately InformativeDirect
Biological Process (BP)response to oxygen-containing compound7.93e-122.387e-11Moderately InformativeDirect
Biological Process (BP)cellular response to chemical stimulus0.00014770.00765Moderately InformativeInherited
Biological Process (BP)regulation of cellular metabolic process0.040220.06246Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.0037670.8869Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.42325.841e-05Moderately InformativeInherited
Biological Process (BP)carbohydrate metabolic process1.47e-050.01277Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.00093340.2411Moderately InformativeInherited
Biological Process (BP)tissue development0.011650.0916Moderately InformativeInherited
Biological Process (BP)organic substance transport3.394e-070.007935Moderately InformativeInherited
Biological Process (BP)organ development0.0043430.002075Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.00041220.004648Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.030570.0003194Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.025320.09602Moderately InformativeInherited
Biological Process (BP)regulation of molecular function0.0076890.2291Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.003240.00102Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.096650.7567Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.0006480.3844Moderately InformativeInherited
Biological Process (BP)signal transduction0.031190.006808Moderately InformativeInherited
Biological Process (BP)regulation of protein phosphorylation7.964e-120InformativeDirect
Biological Process (BP)enzyme linked receptor protein signaling pathway05.433e-10InformativeDirect
Biological Process (BP)response to hormone stimulus5.97e-055.62e-09InformativeDirect
Biological Process (BP)response to organic nitrogen1.236e-066.292e-10InformativeDirect
Biological Process (BP)lipid catabolic process1.137e-092.832e-06InformativeDirect
Biological Process (BP)regulation of lipid metabolic process2.11e-071.649e-05InformativeDirect
Biological Process (BP)hexose metabolic process1.132e-082.37e-05InformativeDirect
Biological Process (BP)regulation of organelle organization0.00016788.812e-09InformativeDirect
Biological Process (BP)regulation of apoptotic process1.639e-120InformativeDirect
Biological Process (BP)muscle structure development3.265e-070.0004256InformativeDirect
Biological Process (BP)cellular response to nitrogen compound2.379e-087.048e-12InformativeDirect
Biological Process (BP)cellular response to oxygen-containing compound0.00016314.824e-07InformativeDirect
Biological Process (BP)regulation of response to stress0.050851InformativeInherited
Biological Process (BP)cellular response to endogenous stimulus0.0055820.01075InformativeInherited
Biological Process (BP)muscle tissue development9.608e-120.01277InformativeInherited
Biological Process (BP)regulation of intracellular protein kinase cascade0.20480.8729InformativeInherited
Biological Process (BP)regulation of kinase activity0.048661InformativeInherited
Biological Process (BP)positive regulation of phosphorus metabolic process7.745e-050.01764InformativeInherited
Biological Process (BP)protein phosphorylation1.019e-070.008324InformativeInherited
Biological Process (BP)intracellular signal transduction0.0044980.7744InformativeInherited
Biological Process (BP)anatomical structure formation involved in morphogenesis0.00078120.4178InformativeInherited
Biological Process (BP)positive regulation of catalytic activity2.244e-090.004319InformativeInherited
Biological Process (BP)positive regulation of signal transduction0.025960.2277InformativeInherited
Biological Process (BP)positive regulation of protein metabolic process0.0005020.1755InformativeInherited
Biological Process (BP)MAPK cascade2.819e-123.482e-07Highly InformativeDirect
Biological Process (BP)ER-nucleus signaling pathway2.35e-090.000153Highly InformativeDirect
Biological Process (BP)transmembrane receptor protein tyrosine kinase signaling pathway00Highly InformativeDirect
Biological Process (BP)carbohydrate transport02.429e-11Highly InformativeDirect
Biological Process (BP)stress-activated protein kinase signaling cascade3.28e-107.197e-09Highly InformativeDirect
Biological Process (BP)response to endoplasmic reticulum stress5.981e-125.902e-07Highly InformativeDirect
Biological Process (BP)positive regulation of lipid metabolic process1.607e-071.157e-06Highly InformativeDirect
Biological Process (BP)regulation of binding2.911e-073.964e-06Highly InformativeDirect
Biological Process (BP)cellular response to biotic stimulus2.887e-098.35e-05Highly InformativeDirect
Biological Process (BP)cellular response to peptide hormone stimulus2.547e-055.339e-08Highly InformativeDirect
Biological Process (BP)regulation of cellular response to stress5.934e-060.02283Highly InformativeInherited
Biological Process (BP)muscle organ development1.711e-060.02063Highly InformativeInherited
Biological Process (BP)response to insulin stimulus0.022480.004128Highly InformativeInherited
Biological Process (BP)regulation of MAP kinase activity0.0020250.8039Highly InformativeInherited
Biological Process (BP)positive regulation of MAPK cascade5.992e-130.4061Highly InformativeInherited
Biological Process (BP)positive regulation of protein serine/threonine kinase activity0.010680.0009832Highly InformativeInherited
Biological Process (BP)activation of protein kinase activity3.879e-140.2715Highly InformativeInherited
Molecular Function (MF)binding0.0062343.052e-08Least InformativeInherited
Molecular Function (MF)protein binding0.0001531.884e-13Moderately InformativeDirect
Molecular Function (MF)receptor binding1.544e-100InformativeDirect
Molecular Function (MF)protein complex binding3.589e-102.752e-11Highly InformativeDirect
Cellular Component (CC)cytoplasmic part0.0094781Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.43581Least InformativeInherited
Cellular Component (CC)extracellular region2.271e-070Moderately InformativeDirect
Cellular Component (CC)vesicle6.054e-138.428e-08Moderately InformativeDirect
Cellular Component (CC)ribonucleoprotein complex6.491e-070.00504Moderately InformativeInherited
Cellular Component (CC)extracellular space0.00038214.667e-15InformativeDirect
Cellular Component (CC)secretory granule01.207e-14InformativeDirect
Cellular Component (CC)small nucleolar ribonucleoprotein complex1.123e-144.284e-12Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 1.182e-12 Least Informative Direct
Biological Process (BP) developmental process 3.905e-09 Least Informative Direct
Biological Process (BP) regulation of cellular process 0 Least Informative Direct
Biological Process (BP) biosynthetic process 0.5329 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.003859 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.1831 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.03574 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.7256 Least Informative Inherited
Biological Process (BP) response to stimulus 0.003286 Least Informative Inherited
Biological Process (BP) localization 0.771 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.008907 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.1826 Least Informative Inherited
Biological Process (BP) reproduction 4.171e-10 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 1.958e-08 Moderately Informative Direct
Biological Process (BP) regulation of biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0 Moderately Informative Direct
Biological Process (BP) response to organic substance 6.589e-08 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0 Moderately Informative Direct
Biological Process (BP) cell differentiation 3.029e-06 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.0003194 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 1.749e-05 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 4.008e-15 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 5.841e-05 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 2.387e-11 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.00765 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 0.06246 Moderately Informative Inherited
Biological Process (BP) tissue development 0.0916 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.09602 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.755 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.003427 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.01454 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.003838 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.004648 Moderately Informative Inherited
Biological Process (BP) organ development 0.002075 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.00124 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.1062 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.8869 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.02311 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.8304 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.01277 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.2411 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.007935 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 0.8076 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.00102 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.2291 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.7567 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.3844 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.006808 Moderately Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.0001097 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 5.433e-10 Informative Direct
Biological Process (BP) response to hormone stimulus 5.62e-09 Informative Direct
Biological Process (BP) response to organic nitrogen 6.292e-10 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1.654e-06 Informative Direct
Biological Process (BP) lipid catabolic process 2.832e-06 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 1.649e-05 Informative Direct
Biological Process (BP) hexose metabolic process 2.37e-05 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 1.993e-07 Informative Direct
Biological Process (BP) regulation of organelle organization 8.812e-09 Informative Direct
Biological Process (BP) growth 8.339e-09 Informative Direct
Biological Process (BP) regulation of apoptotic process 0 Informative Direct
Biological Process (BP) sulfur compound biosynthetic process 2.978e-07 Informative Direct
Biological Process (BP) gland development 8.737e-06 Informative Direct
Biological Process (BP) positive regulation of transport 1.546e-06 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0 Informative Direct
Biological Process (BP) regulation of nervous system development 9.836e-05 Informative Direct
Biological Process (BP) negative regulation of cell death 0 Informative Direct
Biological Process (BP) muscle structure development 0.0004256 Informative Direct
Biological Process (BP) reproductive system development 1.278e-05 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 7.048e-12 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 4.824e-07 Informative Direct
Biological Process (BP) regulation of cell proliferation 0.02299 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.07306 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.03943 Informative Inherited
Biological Process (BP) organ morphogenesis 0.1573 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.00332 Informative Inherited
Biological Process (BP) epithelium development 0.7342 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.1517 Informative Inherited
Biological Process (BP) cardiovascular system development 0.2453 Informative Inherited
Biological Process (BP) tube development 0.06537 Informative Inherited
Biological Process (BP) sensory organ development 0.07655 Informative Inherited
Biological Process (BP) regulation of response to stress 1 Informative Inherited
Biological Process (BP) response to wounding 0.01279 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.06659 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.01075 Informative Inherited
Biological Process (BP) muscle tissue development 0.01277 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.8729 Informative Inherited
Biological Process (BP) positive regulation of phosphorus metabolic process 0.01764 Informative Inherited
Biological Process (BP) regulation of kinase activity 1 Informative Inherited
Biological Process (BP) protein phosphorylation 0.008324 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.7744 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.4178 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 0.1755 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.004319 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.2277 Informative Inherited
Biological Process (BP) MAPK cascade 3.482e-07 Highly Informative Direct
Biological Process (BP) aminoglycan biosynthetic process 5.314e-11 Highly Informative Direct
Biological Process (BP) ER-nucleus signaling pathway 0.000153 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0 Highly Informative Direct
Biological Process (BP) carbohydrate transport 2.429e-11 Highly Informative Direct
Biological Process (BP) glial cell differentiation 3.157e-06 Highly Informative Direct
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of mitochondrion organization 0 Highly Informative Direct
Biological Process (BP) glycosaminoglycan metabolic process 1.086e-09 Highly Informative Direct
Biological Process (BP) lung development 2.36e-05 Highly Informative Direct
Biological Process (BP) stress-activated protein kinase signaling cascade 7.197e-09 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 5.902e-07 Highly Informative Direct
Biological Process (BP) wound healing 0.0001828 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic process 4.919e-05 Highly Informative Direct
Biological Process (BP) multi-multicellular organism process 0.0003247 Highly Informative Direct
Biological Process (BP) positive regulation of lipid metabolic process 1.157e-06 Highly Informative Direct
Biological Process (BP) developmental growth 3.951e-07 Highly Informative Direct
Biological Process (BP) inner ear development 0.0001866 Highly Informative Direct
Biological Process (BP) regulation of binding 3.964e-06 Highly Informative Direct
Biological Process (BP) positive regulation of protein kinase B signaling cascade 1.981e-05 Highly Informative Direct
Biological Process (BP) epithelial tube morphogenesis 6.308e-06 Highly Informative Direct
Biological Process (BP) morphogenesis of a branching epithelium 1.366e-07 Highly Informative Direct
Biological Process (BP) connective tissue development 0.0001108 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 8.35e-05 Highly Informative Direct
Biological Process (BP) cellular response to peptide hormone stimulus 5.339e-08 Highly Informative Direct
Biological Process (BP) positive regulation of protein serine/threonine kinase activity 0.0009832 Highly Informative Direct
Biological Process (BP) regulation of neural precursor cell proliferation 6.927e-07 Highly Informative Direct
Biological Process (BP) regulation of apoptotic signaling pathway 0 Highly Informative Direct
Biological Process (BP) regulation of ERK1 and ERK2 cascade 0.04852 Highly Informative Inherited
Biological Process (BP) negative regulation of signal transduction 0.9901 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.02283 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.02063 Highly Informative Inherited
Biological Process (BP) response to insulin stimulus 0.004128 Highly Informative Inherited
Biological Process (BP) regulation of MAP kinase activity 0.8039 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 0.4061 Highly Informative Inherited
Biological Process (BP) activation of protein kinase activity 0.2715 Highly Informative Inherited
Molecular Function (MF) binding 3.052e-08 Least Informative Direct
Molecular Function (MF) protein binding 1.884e-13 Moderately Informative Direct
Molecular Function (MF) receptor binding 0 Informative Direct
Molecular Function (MF) protein complex binding 2.752e-11 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) extracellular region 0 Moderately Informative Direct
Cellular Component (CC) vesicle 8.428e-08 Moderately Informative Direct
Cellular Component (CC) ribonucleoprotein complex 0.00504 Moderately Informative Inherited
Cellular Component (CC) extracellular space 4.667e-15 Informative Direct
Cellular Component (CC) secretory granule 1.207e-14 Informative Direct
Cellular Component (CC) small nucleolar ribonucleoprotein complex 4.284e-12 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0Least InformativeDirect
Disease Ontology (DO)nervous system disease0.5018Least InformativeInherited
Disease Ontology (DO)cell type cancer0Moderately InformativeDirect
Disease Ontology (DO)vascular disease0Moderately InformativeDirect
Disease Ontology (DO)disease of metabolism0.0004885Moderately InformativeDirect
Disease Ontology (DO)endocrine system disease0.000529Moderately InformativeDirect
Disease Ontology (DO)lung disease0.007032Moderately InformativeInherited
Disease Ontology (DO)brain disease0.01145Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.01787Moderately InformativeInherited
Disease Ontology (DO)syndrome0.019Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.1177Moderately InformativeInherited
Disease Ontology (DO)hypertension0InformativeDirect
Disease Ontology (DO)carcinoma0InformativeDirect
Disease Ontology (DO)overnutrition3.988e-05InformativeDirect
Disease Ontology (DO)in situ carcinoma9.863e-05InformativeDirect
Disease Ontology (DO)motor neuron disease0.0001326InformativeDirect
Disease Ontology (DO)endocrine gland cancer0.001978InformativeInherited
Disease Ontology (DO)liver disease0.005946InformativeInherited
Disease Ontology (DO)pancreas disease0.1361InformativeInherited
Disease Ontology (DO)interstitial lung disease0.0001164Highly InformativeDirect
Disease Ontology (DO)liver cirrhosis0.0002175Highly InformativeDirect
Disease Ontology (DO)gonadal disease0.001228Highly InformativeInherited

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.02332Least InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology1.505e-05Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal skeleton morphology0.01176Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal circulating glucose level0.04702InformativeInherited
Mammalian Phenotype (MP)abnormal prenatal growth/weight/body size0.06584InformativeInherited
Mammalian Phenotype (MP)abnormal bone structure0.2097InformativeInherited
Mammalian Phenotype (MP)decreased birth weight2.828e-06Highly InformativeDirect
Mammalian Phenotype (MP)abnormal endocrine pancreas morphology0.001217Highly InformativeInherited
Mammalian Phenotype (MP)abnormal prenatal body size0.4504Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.0002272Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.05851Least InformativeInherited
Worm Phenotype (WP)locomotion variant1.298e-05Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant9.153e-05Moderately InformativeDirect
Worm Phenotype (WP)lipid metabolism variant0.0003172InformativeDirect
Worm Phenotype (WP)body length variant0.0004554InformativeDirect
Worm Phenotype (WP)body width variant0.0006215InformativeDirect
Worm Phenotype (WP)dauer development variant1.519e-10Highly InformativeDirect
Worm Phenotype (WP)dauer arrest variant8.647e-10Highly InformativeDirect
Worm Phenotype (WP)small2.592e-06Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)mating defective5.695e-05InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)alimentary system0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)liver and biliary system0InformativeDirect
Xenopus DEvelopment stage (XDE)embryonic stage0Least InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processGlucose metabolism0Highly InformativeDirect
Biological processOsteogenesis0Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
DomainSignal0Least InformativeDirect
Post-translational modificationGrowth factor0InformativeDirect
Post-translational modificationHormone0Highly InformativeDirect
Post-translational modificationMitogen0Highly InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues0Moderately InformativeDirect
Post-translational modificationPyrrolidone carboxylic acid0InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 11 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Insulin-like domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 11 hidden Markov models representing the Insulin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


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Please cite: Gough, J., Karplus, K., Hughey, R. and Chothia, C. (2001). "Assignment of Homology to Genome Sequences using a Library of Hidden Markov Models that Represent all Proteins of Known Structure." J. Mol. Biol., 313(4), 903-919.

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© Copyright 2013 The SUPERFAMILY authors and Julian Gough.