SUPERFAMILY 1.75 HMM library and genome assignments server


Insulin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Insulin-like [ 56993]
Superfamily:   Insulin-like [ 56994]
Families:   Insulin-like [ 56995] (4)


Superfamily statistics
Genomes (136) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 959 1,683 48
Proteins 954 1,680 48


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process2.064e-083.203e-13Least InformativeDirect
Biological Process (BP)developmental process3.027e-071.506e-09Least InformativeDirect
Biological Process (BP)response to stimulus3.073e-050.0008687Least InformativeDirect
Biological Process (BP)regulation of cellular process0.097020.004403Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.23840.3293Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.01850.04248Least InformativeInherited
Biological Process (BP)localization0.002020.7086Least InformativeInherited
Biological Process (BP)single-organism cellular process0.14020.2445Least InformativeInherited
Biological Process (BP)response to endogenous stimulus2.402e-077.322e-08Moderately InformativeDirect
Biological Process (BP)positive regulation of metabolic process4.727e-110Moderately InformativeDirect
Biological Process (BP)regulation of signal transduction0.00073615.777e-08Moderately InformativeDirect
Biological Process (BP)response to organic substance5.229e-104.407e-08Moderately InformativeDirect
Biological Process (BP)regulation of macromolecule biosynthetic process1.188e-105.4e-05Moderately InformativeDirect
Biological Process (BP)cell differentiation1.017e-052.161e-06Moderately InformativeDirect
Biological Process (BP)regulation of cellular biosynthetic process3.436e-100Moderately InformativeDirect
Biological Process (BP)positive regulation of molecular function4.456e-081.362e-05Moderately InformativeDirect
Biological Process (BP)single-organism developmental process0.00022633.811e-06Moderately InformativeDirect
Biological Process (BP)response to oxygen-containing compound1.205e-111.545e-11Moderately InformativeDirect
Biological Process (BP)cellular response to chemical stimulus0.00025390.01575Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.0023240.001234Moderately InformativeInherited
Biological Process (BP)regulation of catalytic activity0.013340.4715Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process11.238e-12Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.010970.9421Moderately InformativeInherited
Biological Process (BP)carbohydrate metabolic process1.635e-050.01877Moderately InformativeInherited
Biological Process (BP)tissue development0.016680.1025Moderately InformativeInherited
Biological Process (BP)organic substance transport3.464e-070.005015Moderately InformativeInherited
Biological Process (BP)organ development0.0055410.0025Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.03540.05778Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.033990.001047Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.023210.1424Moderately InformativeInherited
Biological Process (BP)signal transduction0.025230.00627Moderately InformativeInherited
Biological Process (BP)regulation of protein phosphorylation1.764e-110InformativeDirect
Biological Process (BP)apoptotic process2.215e-083.052e-12InformativeDirect
Biological Process (BP)enzyme linked receptor protein signaling pathway01.508e-10InformativeDirect
Biological Process (BP)response to hormone stimulus5.256e-052.695e-09InformativeDirect
Biological Process (BP)response to organonitrogen compound9.733e-079.149e-10InformativeDirect
Biological Process (BP)lipid catabolic process1.175e-091.573e-06InformativeDirect
Biological Process (BP)regulation of lipid metabolic process2.122e-072.554e-05InformativeDirect
Biological Process (BP)hexose metabolic process8.932e-091.727e-05InformativeDirect
Biological Process (BP)regulation of apoptotic process0.0001660InformativeDirect
Biological Process (BP)single-organism behavior0.00013969.248e-05InformativeDirect
Biological Process (BP)muscle structure development2.976e-070.0003685InformativeDirect
Biological Process (BP)cellular response to nitrogen compound1.975e-081.19e-11InformativeDirect
Biological Process (BP)cellular response to oxygen-containing compound0.00022471.237e-06InformativeDirect
Biological Process (BP)cellular response to endogenous stimulus0.0057840.01285InformativeInherited
Biological Process (BP)muscle tissue development1.428e-110.01008InformativeInherited
Biological Process (BP)regulation of intracellular protein kinase cascade0.087090.5887InformativeInherited
Biological Process (BP)regulation of kinase activity0.033071InformativeInherited
Biological Process (BP)positive regulation of signal transduction0.035360.2813InformativeInherited
Biological Process (BP)positive regulation of protein modification process2.587e-120.3224InformativeInherited
Biological Process (BP)positive regulation of phosphate metabolic process2.523e-120.03452InformativeInherited
Biological Process (BP)intracellular signal transduction0.0034170.7146InformativeInherited
Biological Process (BP)anatomical structure formation involved in morphogenesis0.0011660.3749InformativeInherited
Biological Process (BP)MAPK cascade1.698e-121.464e-07Highly InformativeDirect
Biological Process (BP)ER-nucleus signaling pathway2.886e-090.0001424Highly InformativeDirect
Biological Process (BP)transmembrane receptor protein tyrosine kinase signaling pathway00Highly InformativeDirect
Biological Process (BP)carbohydrate transport01.142e-11Highly InformativeDirect
Biological Process (BP)stress-activated protein kinase signaling cascade7.005e-103.47e-09Highly InformativeDirect
Biological Process (BP)response to endoplasmic reticulum stress6.864e-124.922e-07Highly InformativeDirect
Biological Process (BP)response to peptide hormone stimulus02.118e-08Highly InformativeDirect
Biological Process (BP)positive regulation of lipid metabolic process7.197e-081.506e-06Highly InformativeDirect
Biological Process (BP)regulation of binding4.731e-081.442e-06Highly InformativeDirect
Biological Process (BP)cellular response to biotic stimulus3.716e-103.691e-06Highly InformativeDirect
Biological Process (BP)regulation of cellular response to insulin stimulus8.672e-107.949e-09Highly InformativeDirect
Biological Process (BP)cellular response to peptide8.651e-082.101e-11Highly InformativeDirect
Biological Process (BP)intrinsic apoptotic signaling pathway4.923e-060.002273Highly InformativeInherited
Biological Process (BP)regulation of cellular response to stress5.584e-070.01179Highly InformativeInherited
Biological Process (BP)muscle organ development1.322e-060.01868Highly InformativeInherited
Biological Process (BP)regulation of MAP kinase activity0.0010070.6679Highly InformativeInherited
Biological Process (BP)positive regulation of MAPK cascade2.071e-120.4787Highly InformativeInherited
Biological Process (BP)positive regulation of protein kinase activity0.0029430.0346Highly InformativeInherited
Molecular Function (MF)binding0.00055485.51e-10Least InformativeDirect
Molecular Function (MF)receptor binding3.073e-090InformativeDirect
Molecular Function (MF)protein complex binding3.236e-095.112e-11Highly InformativeDirect
Cellular Component (CC)cytoplasmic part0.0076060.9924Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.33531Least InformativeInherited
Cellular Component (CC)vesicle6.983e-101.29e-05Moderately InformativeDirect
Cellular Component (CC)extracellular region part0.00081931.237e-11Moderately InformativeDirect
Cellular Component (CC)ribonucleoprotein complex6.33e-070.002908Moderately InformativeInherited
Cellular Component (CC)extracellular space5.948e-054.672e-06InformativeDirect
Cellular Component (CC)secretory granule06.075e-15InformativeDirect
Cellular Component (CC)small nucleolar ribonucleoprotein complex8.396e-151.938e-12Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 3.203e-13 Least Informative Direct
Biological Process (BP) developmental process 1.506e-09 Least Informative Direct
Biological Process (BP) response to stimulus 0.0008687 Least Informative Direct
Biological Process (BP) biosynthetic process 0.4925 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.004403 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.3293 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.04248 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.7049 Least Informative Inherited
Biological Process (BP) localization 0.7086 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.2445 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.2428 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.8214 Least Informative Inherited
Biological Process (BP) reproduction 1.798e-10 Moderately Informative Direct
Biological Process (BP) sulfur compound metabolic process 1.15e-05 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 7.322e-08 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 5.777e-08 Moderately Informative Direct
Biological Process (BP) response to organic substance 4.407e-08 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 5.4e-05 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 1.238e-12 Moderately Informative Direct
Biological Process (BP) cell differentiation 2.161e-06 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 1.362e-05 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 3.811e-06 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 2.389e-05 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 5.374e-05 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 1.545e-11 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.01575 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.00627 Moderately Informative Inherited
Biological Process (BP) tissue development 0.1025 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.1424 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.8997 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.005541 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.01331 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.002986 Moderately Informative Inherited
Biological Process (BP) organ development 0.0025 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.006663 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.111 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.001234 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.4715 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.9421 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.946 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.01877 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.05778 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.001047 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.005015 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.0002836 Informative Direct
Biological Process (BP) apoptotic process 3.052e-12 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 1.508e-10 Informative Direct
Biological Process (BP) response to hormone stimulus 2.695e-09 Informative Direct
Biological Process (BP) response to organonitrogen compound 9.149e-10 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1.467e-06 Informative Direct
Biological Process (BP) lipid catabolic process 1.573e-06 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 2.554e-05 Informative Direct
Biological Process (BP) hexose metabolic process 1.727e-05 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 1.73e-07 Informative Direct
Biological Process (BP) regulation of organelle organization 2.572e-10 Informative Direct
Biological Process (BP) growth 3.64e-08 Informative Direct
Biological Process (BP) regulation of apoptotic process 0 Informative Direct
Biological Process (BP) sulfur compound biosynthetic process 2.073e-07 Informative Direct
Biological Process (BP) multi-multicellular organism process 0.0003154 Informative Direct
Biological Process (BP) single-organism behavior 9.248e-05 Informative Direct
Biological Process (BP) gland development 4.503e-06 Informative Direct
Biological Process (BP) positive regulation of transport 2.611e-06 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 9.53e-12 Informative Direct
Biological Process (BP) regulation of nervous system development 0.0001591 Informative Direct
Biological Process (BP) negative regulation of cell death 0 Informative Direct
Biological Process (BP) muscle structure development 0.0003685 Informative Direct
Biological Process (BP) reproductive system development 1.456e-05 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 1.19e-11 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 1.237e-06 Informative Direct
Biological Process (BP) regulation of cell proliferation 0.0233 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.02204 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.01445 Informative Inherited
Biological Process (BP) organ morphogenesis 0.1323 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.004698 Informative Inherited
Biological Process (BP) epithelium development 0.7329 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.1374 Informative Inherited
Biological Process (BP) cardiovascular system development 0.2316 Informative Inherited
Biological Process (BP) tube development 0.03913 Informative Inherited
Biological Process (BP) sensory organ development 0.06558 Informative Inherited
Biological Process (BP) response to wounding 0.01778 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.011 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.01285 Informative Inherited
Biological Process (BP) muscle tissue development 0.01008 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.2813 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.5887 Informative Inherited
Biological Process (BP) regulation of kinase activity 1 Informative Inherited
Biological Process (BP) positive regulation of protein modification process 0.3224 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.03452 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.7146 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.3749 Informative Inherited
Biological Process (BP) MAPK cascade 1.464e-07 Highly Informative Direct
Biological Process (BP) aminoglycan biosynthetic process 2.839e-11 Highly Informative Direct
Biological Process (BP) ER-nucleus signaling pathway 0.0001424 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0 Highly Informative Direct
Biological Process (BP) carbohydrate transport 1.142e-11 Highly Informative Direct
Biological Process (BP) glial cell differentiation 4.065e-06 Highly Informative Direct
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of mitochondrion organization 0 Highly Informative Direct
Biological Process (BP) glycosaminoglycan metabolic process 4.453e-10 Highly Informative Direct
Biological Process (BP) respiratory tube development 2.562e-05 Highly Informative Direct
Biological Process (BP) stress-activated protein kinase signaling cascade 3.47e-09 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 4.922e-07 Highly Informative Direct
Biological Process (BP) wound healing 0.0001384 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic process 1.856e-09 Highly Informative Direct
Biological Process (BP) response to peptide hormone stimulus 2.118e-08 Highly Informative Direct
Biological Process (BP) ear development 0.0003463 Highly Informative Direct
Biological Process (BP) positive regulation of lipid metabolic process 1.506e-06 Highly Informative Direct
Biological Process (BP) regulation of glucose import 0 Highly Informative Direct
Biological Process (BP) developmental growth 4.964e-07 Highly Informative Direct
Biological Process (BP) branching morphogenesis of an epithelial tube 3.037e-08 Highly Informative Direct
Biological Process (BP) regulation of binding 1.442e-06 Highly Informative Direct
Biological Process (BP) regulation of protein kinase B signaling cascade 4.002e-05 Highly Informative Direct
Biological Process (BP) connective tissue development 9.819e-05 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 3.691e-06 Highly Informative Direct
Biological Process (BP) extrinsic apoptotic signaling pathway 4.983e-06 Highly Informative Direct
Biological Process (BP) regulation of cellular response to insulin stimulus 7.949e-09 Highly Informative Direct
Biological Process (BP) cellular response to peptide 2.101e-11 Highly Informative Direct
Biological Process (BP) regulation of neural precursor cell proliferation 2.147e-06 Highly Informative Direct
Biological Process (BP) intrinsic apoptotic signaling pathway 0.002273 Highly Informative Inherited
Biological Process (BP) respiratory system development 0.001242 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.01179 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.01868 Highly Informative Inherited
Biological Process (BP) regulation of MAP kinase activity 0.6679 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 0.4787 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 0.0346 Highly Informative Inherited
Molecular Function (MF) binding 5.51e-10 Least Informative Direct
Molecular Function (MF) receptor binding 0 Informative Direct
Molecular Function (MF) protein complex binding 5.112e-11 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.9924 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) vesicle 1.29e-05 Moderately Informative Direct
Cellular Component (CC) extracellular region part 1.237e-11 Moderately Informative Direct
Cellular Component (CC) ribonucleoprotein complex 0.002908 Moderately Informative Inherited
Cellular Component (CC) extracellular space 4.672e-06 Informative Direct
Cellular Component (CC) secretory granule 6.075e-15 Informative Direct
Cellular Component (CC) small nucleolar ribonucleoprotein complex 1.938e-12 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0Least InformativeDirect
Disease Ontology (DO)nervous system disease0.2612Least InformativeInherited
Disease Ontology (DO)cell type cancer0Moderately InformativeDirect
Disease Ontology (DO)artery disease0Moderately InformativeDirect
Disease Ontology (DO)endocrine system disease0.0001473Moderately InformativeDirect
Disease Ontology (DO)disease of metabolism0.001831Moderately InformativeInherited
Disease Ontology (DO)lung disease0.003073Moderately InformativeInherited
Disease Ontology (DO)syndrome0.005719Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.008517Moderately InformativeInherited
Disease Ontology (DO)hypertension0InformativeDirect
Disease Ontology (DO)overnutrition7.551e-06InformativeDirect
Disease Ontology (DO)in situ carcinoma3.545e-05InformativeDirect
Disease Ontology (DO)motor neuron disease4.882e-05InformativeDirect
Disease Ontology (DO)liver disease0.00264InformativeInherited
Disease Ontology (DO)pancreas disease0.1221InformativeInherited
Disease Ontology (DO)hyperandrogenism4.027e-08Highly InformativeDirect
Disease Ontology (DO)interstitial lung disease4.778e-05Highly InformativeDirect
Disease Ontology (DO)synucleinopathy5.35e-05Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.04805Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body phenotype0.1985Least InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal skeleton morphology0.007724Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.1737Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal male germ cell morphology0.0009701InformativeDirect
Mammalian Phenotype (MP)abnormal bone mineral density0.001817InformativeInherited
Mammalian Phenotype (MP)abnormal prenatal growth/weight/body size0.01791InformativeInherited
Mammalian Phenotype (MP)abnormal circulating glucose level0.02169InformativeInherited
Mammalian Phenotype (MP)abnormal sex determination0.09916InformativeInherited
Mammalian Phenotype (MP)abnormal pancreas morphology0.1224InformativeInherited
Mammalian Phenotype (MP)decreased birth weight1.6e-06Highly InformativeDirect
Mammalian Phenotype (MP)decreased fetal size0.0005577Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pancreatic islet morphology0.000806Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.0002272Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.05851Least InformativeInherited
Worm Phenotype (WP)locomotion variant1.298e-05Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant9.153e-05Moderately InformativeDirect
Worm Phenotype (WP)lipid metabolism variant0.0003172InformativeDirect
Worm Phenotype (WP)body length variant0.0004554InformativeDirect
Worm Phenotype (WP)body width variant0.0006215InformativeDirect
Worm Phenotype (WP)dauer development variant1.519e-10Highly InformativeDirect
Worm Phenotype (WP)dauer arrest variant8.647e-10Highly InformativeDirect
Worm Phenotype (WP)small2.592e-06Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)mating defective0.0001283Highly InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)alimentary system0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus DEvelopment stage (XDE)embryonic stage0Least InformativeDirect
Xenopus DEvelopment stage (XDE)NF stage0Least InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processGlucose metabolism0Highly InformativeDirect
Biological processOsteogenesis0Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
DomainSignal0Least InformativeDirect
Post-translational modificationGrowth factor0InformativeDirect
Post-translational modificationHormone0Highly InformativeDirect
Post-translational modificationMitogen0Highly InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues0Moderately InformativeDirect
Post-translational modificationPyrrolidone carboxylic acid0InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 11 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Insulin-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 11 hidden Markov models representing the Insulin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]