SUPERFAMILY 1.75 HMM library and genome assignments server


Insulin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Insulin-like [ 56993]
Superfamily:   Insulin-like [ 56994]
Families:   Insulin-like [ 56995] (4)


Superfamily statistics
Genomes (131) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 924 1,683 48
Proteins 919 1,680 48


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process0.000000016280.00000000000009491Least InformativeDirect
Biological Process (BP)developmental process0.00000024230.0000000005799Least InformativeDirect
Biological Process (BP)response to stimulus0.000021660.0004141Least InformativeDirect
Biological Process (BP)regulation of cellular process0.10890.004757Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.24510.3399Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.014670.03006Least InformativeInherited
Biological Process (BP)localization0.0018030.661Least InformativeInherited
Biological Process (BP)single-organism cellular process0.14210.249Least InformativeInherited
Biological Process (BP)response to endogenous stimulus0.00000020490.00000004841Moderately InformativeDirect
Biological Process (BP)regulation of biosynthetic process0.00000000037680Moderately InformativeDirect
Biological Process (BP)positive regulation of metabolic process0.000000000033170Moderately InformativeDirect
Biological Process (BP)regulation of signal transduction0.00085880.00000006688Moderately InformativeDirect
Biological Process (BP)response to organic substance0.00000000034480.0000000183Moderately InformativeDirect
Biological Process (BP)cell differentiation0.000008240.000001204Moderately InformativeDirect
Biological Process (BP)positive regulation of molecular function0.000000039190.000008845Moderately InformativeDirect
Biological Process (BP)single-organism developmental process0.00023050.000003713Moderately InformativeDirect
Biological Process (BP)response to oxygen-containing compound0.0000000000092490.00000000000757Moderately InformativeDirect
Biological Process (BP)cellular response to chemical stimulus0.00027820.01543Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.0023570.001214Moderately InformativeInherited
Biological Process (BP)regulation of catalytic activity0.014660.4692Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process10.000000000000581Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.011130.9447Moderately InformativeInherited
Biological Process (BP)carbohydrate metabolic process0.000013770.01604Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.00089670.2371Moderately InformativeInherited
Biological Process (BP)tissue development0.016190.1005Moderately InformativeInherited
Biological Process (BP)organic substance transport0.00000029890.00417Moderately InformativeInherited
Biological Process (BP)organ development0.0053820.002467Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.035760.05436Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.03350.0009411Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.022150.1418Moderately InformativeInherited
Biological Process (BP)signal transduction0.025510.006447Moderately InformativeInherited
Biological Process (BP)regulation of protein phosphorylation0.000000000014660InformativeDirect
Biological Process (BP)enzyme linked receptor protein signaling pathway00.000000000115InformativeDirect
Biological Process (BP)response to hormone stimulus0.000045870.000000002166InformativeDirect
Biological Process (BP)response to organonitrogen compound0.0000011640.00000000111InformativeDirect
Biological Process (BP)programmed cell death0.000000037960.00000000001537InformativeDirect
Biological Process (BP)lipid catabolic process0.00000000094460.000001209InformativeDirect
Biological Process (BP)regulation of lipid metabolic process0.00000019410.00002253InformativeDirect
Biological Process (BP)hexose metabolic process0.0000000080230.00001466InformativeDirect
Biological Process (BP)regulation of apoptotic process0.00014570InformativeDirect
Biological Process (BP)muscle structure development0.00000024660.0003458InformativeDirect
Biological Process (BP)cellular response to nitrogen compound0.000000018970.00000000001314InformativeDirect
Biological Process (BP)cellular response to oxygen-containing compound0.000220.000001271InformativeDirect
Biological Process (BP)regulation of response to stress0.062191InformativeInherited
Biological Process (BP)cellular response to endogenous stimulus0.0068410.01601InformativeInherited
Biological Process (BP)muscle tissue development0.0000000000091090.009907InformativeInherited
Biological Process (BP)regulation of intracellular protein kinase cascade0.080080.5675InformativeInherited
Biological Process (BP)regulation of kinase activity0.036481InformativeInherited
Biological Process (BP)positive regulation of signal transduction0.03330.2818InformativeInherited
Biological Process (BP)positive regulation of protein modification process0.0000000000020650.3098InformativeInherited
Biological Process (BP)positive regulation of phosphate metabolic process0.000000000002010.03154InformativeInherited
Biological Process (BP)intracellular signal transduction0.003860.7557InformativeInherited
Biological Process (BP)anatomical structure formation involved in morphogenesis0.0010650.3643InformativeInherited
Biological Process (BP)MAPK cascade0.0000000000013980.0000001132Highly InformativeDirect
Biological Process (BP)ER-nucleus signaling pathway0.0000000034910.0001483Highly InformativeDirect
Biological Process (BP)transmembrane receptor protein tyrosine kinase signaling pathway00Highly InformativeDirect
Biological Process (BP)carbohydrate transport00.00000000001217Highly InformativeDirect
Biological Process (BP)stress-activated protein kinase signaling cascade0.00000000076430.000000002839Highly InformativeDirect
Biological Process (BP)response to endoplasmic reticulum stress0.0000000000065880.0000003983Highly InformativeDirect
Biological Process (BP)response to peptide hormone stimulus00.0000000374Highly InformativeDirect
Biological Process (BP)positive regulation of lipid metabolic process0.000000084630.000001726Highly InformativeDirect
Biological Process (BP)regulation of binding0.00000004710.000001283Highly InformativeDirect
Biological Process (BP)cellular response to biotic stimulus0.00000000035270.000003373Highly InformativeDirect
Biological Process (BP)regulation of cellular response to insulin stimulus0.00000000094950.000000008549Highly InformativeDirect
Biological Process (BP)cellular response to peptide0.000000092430.00000000002406Highly InformativeDirect
Biological Process (BP)intrinsic apoptotic signaling pathway0.0000046960.002048Highly InformativeInherited
Biological Process (BP)regulation of cellular response to stress0.00000062280.01059Highly InformativeInherited
Biological Process (BP)muscle organ development0.0000010430.01654Highly InformativeInherited
Biological Process (BP)regulation of MAP kinase activity0.0012090.7132Highly InformativeInherited
Biological Process (BP)positive regulation of MAPK cascade0.0000000000011870.4367Highly InformativeInherited
Biological Process (BP)positive regulation of protein kinase activity0.0032590.03851Highly InformativeInherited
Molecular Function (MF)binding0.00038990.000000000126Least InformativeDirect
Molecular Function (MF)receptor binding0.0000000034390InformativeDirect
Molecular Function (MF)protein complex binding0.0000000029590.0000000000458Highly InformativeDirect
Cellular Component (CC)cytoplasmic part0.00620.9382Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.34391Least InformativeInherited
Cellular Component (CC)vesicle0.00000000038160.000005999Moderately InformativeDirect
Cellular Component (CC)extracellular region part0.00064920.000000000004133Moderately InformativeDirect
Cellular Component (CC)ribonucleoprotein complex0.00000063940.002423Moderately InformativeInherited
Cellular Component (CC)secretory granule00.000000000000004676InformativeDirect
Cellular Component (CC)small nucleolar ribonucleoprotein complex0.0000000000000085030.000000000001618Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0.00000000000009491 Least Informative Direct
Biological Process (BP) developmental process 0.0000000005799 Least Informative Direct
Biological Process (BP) response to stimulus 0.0004141 Least Informative Direct
Biological Process (BP) biosynthetic process 0.4385 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.004757 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.3399 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.03006 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.647 Least Informative Inherited
Biological Process (BP) localization 0.661 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.249 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.2141 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.7745 Least Informative Inherited
Biological Process (BP) reproduction 0.00000000009521 Moderately Informative Direct
Biological Process (BP) sulfur compound metabolic process 0.000007878 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0.00000004841 Moderately Informative Direct
Biological Process (BP) regulation of biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.00000006688 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.0000000183 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0.000000000000581 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.000001204 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 0.000008845 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 0.000003713 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.0009411 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.00002216 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.00005368 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.00000000000757 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.01543 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.006447 Moderately Informative Inherited
Biological Process (BP) tissue development 0.1005 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.1418 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.9001 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.004348 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.01124 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.002213 Moderately Informative Inherited
Biological Process (BP) organ development 0.002467 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.006292 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.08714 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.001214 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.4692 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.9447 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.008332 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.9472 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.01604 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.2371 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.05436 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.00417 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.0002666 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.000000000115 Informative Direct
Biological Process (BP) response to hormone stimulus 0.000000002166 Informative Direct
Biological Process (BP) response to organonitrogen compound 0.00000000111 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.000001417 Informative Direct
Biological Process (BP) programmed cell death 0.00000000001537 Informative Direct
Biological Process (BP) lipid catabolic process 0.000001209 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 0.00002253 Informative Direct
Biological Process (BP) hexose metabolic process 0.00001466 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0.0000001642 Informative Direct
Biological Process (BP) regulation of organelle organization 0.0000000001801 Informative Direct
Biological Process (BP) growth 0.00000000383 Informative Direct
Biological Process (BP) regulation of apoptotic process 0 Informative Direct
Biological Process (BP) sulfur compound biosynthetic process 0.0000001425 Informative Direct
Biological Process (BP) gland development 0.000005073 Informative Direct
Biological Process (BP) positive regulation of transport 0.00000261 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.00000000001116 Informative Direct
Biological Process (BP) regulation of nervous system development 0.0001254 Informative Direct
Biological Process (BP) negative regulation of cell death 0 Informative Direct
Biological Process (BP) muscle structure development 0.0003458 Informative Direct
Biological Process (BP) reproductive system development 0.00001243 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 0.00000000001314 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.000001271 Informative Direct
Biological Process (BP) regulation of cell proliferation 0.02416 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.02098 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.01387 Informative Inherited
Biological Process (BP) organ morphogenesis 0.1362 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.004453 Informative Inherited
Biological Process (BP) epithelium development 0.7461 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.1339 Informative Inherited
Biological Process (BP) cardiovascular system development 0.2343 Informative Inherited
Biological Process (BP) tube development 0.04055 Informative Inherited
Biological Process (BP) sensory organ development 0.06746 Informative Inherited
Biological Process (BP) regulation of response to stress 1 Informative Inherited
Biological Process (BP) response to wounding 0.01837 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.0104 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.01601 Informative Inherited
Biological Process (BP) muscle tissue development 0.009907 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.2818 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.5675 Informative Inherited
Biological Process (BP) regulation of kinase activity 1 Informative Inherited
Biological Process (BP) positive regulation of protein modification process 0.3098 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.03154 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.7557 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.3643 Informative Inherited
Biological Process (BP) MAPK cascade 0.0000001132 Highly Informative Direct
Biological Process (BP) aminoglycan biosynthetic process 0.0000000000221 Highly Informative Direct
Biological Process (BP) ER-nucleus signaling pathway 0.0001483 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0 Highly Informative Direct
Biological Process (BP) carbohydrate transport 0.00000000001217 Highly Informative Direct
Biological Process (BP) glial cell differentiation 0.00000307 Highly Informative Direct
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of mitochondrion organization 0 Highly Informative Direct
Biological Process (BP) glycosaminoglycan metabolic process 0.0000000003226 Highly Informative Direct
Biological Process (BP) respiratory tube development 0.00002675 Highly Informative Direct
Biological Process (BP) stress-activated protein kinase signaling cascade 0.000000002839 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0.0000003983 Highly Informative Direct
Biological Process (BP) wound healing 0.0001103 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic process 0.000000001745 Highly Informative Direct
Biological Process (BP) response to peptide hormone stimulus 0.0000000374 Highly Informative Direct
Biological Process (BP) positive regulation of lipid metabolic process 0.000001726 Highly Informative Direct
Biological Process (BP) regulation of glucose import 0 Highly Informative Direct
Biological Process (BP) developmental growth 0.0000005523 Highly Informative Direct
Biological Process (BP) branching morphogenesis of an epithelial tube 0.00000002643 Highly Informative Direct
Biological Process (BP) inner ear development 0.0001162 Highly Informative Direct
Biological Process (BP) regulation of binding 0.000001283 Highly Informative Direct
Biological Process (BP) regulation of protein kinase B signaling cascade 0.00004872 Highly Informative Direct
Biological Process (BP) connective tissue development 0.00009088 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0.000003373 Highly Informative Direct
Biological Process (BP) extrinsic apoptotic signaling pathway 0.000005412 Highly Informative Direct
Biological Process (BP) regulation of cellular response to insulin stimulus 0.000000008549 Highly Informative Direct
Biological Process (BP) cellular response to peptide 0.00000000002406 Highly Informative Direct
Biological Process (BP) regulation of neural precursor cell proliferation 0.000002588 Highly Informative Direct
Biological Process (BP) regulation of ERK1 and ERK2 cascade 0.08607 Highly Informative Inherited
Biological Process (BP) intrinsic apoptotic signaling pathway 0.002048 Highly Informative Inherited
Biological Process (BP) respiratory system development 0.001339 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.01059 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.01654 Highly Informative Inherited
Biological Process (BP) regulation of MAP kinase activity 0.7132 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 0.4367 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 0.03851 Highly Informative Inherited
Molecular Function (MF) binding 0.000000000126 Least Informative Direct
Molecular Function (MF) receptor binding 0 Informative Direct
Molecular Function (MF) protein complex binding 0.0000000000458 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.9382 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) vesicle 0.000005999 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.000000000004133 Moderately Informative Direct
Cellular Component (CC) ribonucleoprotein complex 0.002423 Moderately Informative Inherited
Cellular Component (CC) secretory granule 0.000000000000004676 Informative Direct
Cellular Component (CC) small nucleolar ribonucleoprotein complex 0.000000000001618 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0Least InformativeDirect
Disease Ontology (DO)nervous system disease0.4305Least InformativeInherited
Disease Ontology (DO)cell type cancer0Moderately InformativeDirect
Disease Ontology (DO)artery disease0Moderately InformativeDirect
Disease Ontology (DO)disease of metabolism0.0004396Moderately InformativeDirect
Disease Ontology (DO)endocrine system disease0.0005818Moderately InformativeDirect
Disease Ontology (DO)lung disease0.006679Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.01739Moderately InformativeInherited
Disease Ontology (DO)syndrome0.01903Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.1148Moderately InformativeInherited
Disease Ontology (DO)hypertension0InformativeDirect
Disease Ontology (DO)overnutrition0.00003386InformativeDirect
Disease Ontology (DO)in situ carcinoma0.00009067InformativeDirect
Disease Ontology (DO)motor neuron disease0.0001251InformativeDirect
Disease Ontology (DO)endocrine gland cancer0.001858InformativeInherited
Disease Ontology (DO)liver disease0.005764InformativeInherited
Disease Ontology (DO)pancreas disease0.1199InformativeInherited
Disease Ontology (DO)hyperandrogenism0.0000001121Highly InformativeDirect
Disease Ontology (DO)polycystic ovary syndrome0.00000102Highly InformativeDirect
Disease Ontology (DO)interstitial lung disease0.0001097Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.04815Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body phenotype0.1996Least InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal skeleton morphology0.007952Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.1726Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal male germ cell morphology0.0009605InformativeDirect
Mammalian Phenotype (MP)abnormal bone mineral density0.00183InformativeInherited
Mammalian Phenotype (MP)abnormal prenatal growth/weight/body size0.0178InformativeInherited
Mammalian Phenotype (MP)abnormal circulating glucose level0.02163InformativeInherited
Mammalian Phenotype (MP)abnormal sex determination0.1013InformativeInherited
Mammalian Phenotype (MP)abnormal pancreas morphology0.1193InformativeInherited
Mammalian Phenotype (MP)decreased birth weight0.000001569Highly InformativeDirect
Mammalian Phenotype (MP)decreased fetal size0.0005703Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pancreatic islet morphology0.0007686Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.0002272Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.05851Least InformativeInherited
Worm Phenotype (WP)locomotion variant0.00001298Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.00009153Moderately InformativeDirect
Worm Phenotype (WP)lipid metabolism variant0.0003172InformativeDirect
Worm Phenotype (WP)body length variant0.0004554InformativeDirect
Worm Phenotype (WP)body width variant0.0006215InformativeDirect
Worm Phenotype (WP)dauer development variant0.0000000001519Highly InformativeDirect
Worm Phenotype (WP)dauer arrest variant0.0000000008647Highly InformativeDirect
Worm Phenotype (WP)small0.000002592Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)mating defective0.00009306Highly InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)alimentary system0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus DEvelopment stage (XDE)embryonic stage0Least InformativeDirect
Xenopus DEvelopment stage (XDE)NF stage0Least InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processGlucose metabolism0Highly InformativeDirect
Biological processOsteogenesis0Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
DomainSignal0Least InformativeDirect
Post-translational modificationGrowth factor0InformativeDirect
Post-translational modificationHormone0Highly InformativeDirect
Post-translational modificationMitogen0Highly InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues0Moderately InformativeDirect
Post-translational modificationPyrrolidone carboxylic acid0InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 11 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Insulin-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 11 hidden Markov models representing the Insulin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]