SUPERFAMILY 1.75 HMM library and genome assignments server


Insulin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Insulin-like [ 56993]
Superfamily:   Insulin-like [ 56994]
Families:   Insulin-like [ 56995] (4)


Superfamily statistics
Genomes (122) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 883 1,498 48
Proteins 879 1,495 48


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process7.202e-099.231e-14Least InformativeDirect
Biological Process (BP)developmental process1.331e-076.334e-10Least InformativeDirect
Biological Process (BP)regulation of cellular process2.311e-110Least InformativeDirect
Biological Process (BP)response to stimulus7.888e-050.00117Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.18240.2946Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.013980.03825Least InformativeInherited
Biological Process (BP)localization0.0014050.6745Least InformativeInherited
Biological Process (BP)single-organism cellular process0.1370.2347Least InformativeInherited
Biological Process (BP)response to endogenous stimulus4.454e-082.659e-08Moderately InformativeDirect
Biological Process (BP)positive regulation of metabolic process2.575e-110Moderately InformativeDirect
Biological Process (BP)regulation of signal transduction1.604e-153.834e-09Moderately InformativeDirect
Biological Process (BP)response to organic substance2.696e-103.204e-08Moderately InformativeDirect
Biological Process (BP)regulation of macromolecule biosynthetic process7.55e-117.254e-05Moderately InformativeDirect
Biological Process (BP)cell differentiation5.816e-061.143e-06Moderately InformativeDirect
Biological Process (BP)regulation of cellular biosynthetic process2.216e-100Moderately InformativeDirect
Biological Process (BP)regulation of programmed cell death0.00020110Moderately InformativeDirect
Biological Process (BP)positive regulation of molecular function1.743e-084.085e-06Moderately InformativeDirect
Biological Process (BP)single-organism developmental process0.00022123.414e-06Moderately InformativeDirect
Biological Process (BP)response to oxygen-containing compound6.803e-121.322e-11Moderately InformativeDirect
Biological Process (BP)cellular response to chemical stimulus0.00026640.01536Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.0021170.001089Moderately InformativeInherited
Biological Process (BP)regulation of catalytic activity0.014720.4784Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process19.913e-13Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.0047120.9055Moderately InformativeInherited
Biological Process (BP)carbohydrate metabolic process1.268e-050.01852Moderately InformativeInherited
Biological Process (BP)tissue development0.014570.0946Moderately InformativeInherited
Biological Process (BP)organic substance transport2.408e-070.00482Moderately InformativeInherited
Biological Process (BP)organ development0.0045960.001976Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.021910.0468Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.032810.0007577Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.021370.1362Moderately InformativeInherited
Biological Process (BP)signal transduction0.028040.008004Moderately InformativeInherited
Biological Process (BP)regulation of protein phosphorylation1.166e-110InformativeDirect
Biological Process (BP)enzyme linked receptor protein signaling pathway01.394e-10InformativeDirect
Biological Process (BP)cell death2.133e-063.032e-09InformativeDirect
Biological Process (BP)response to hormone stimulus4.692e-052.442e-09InformativeDirect
Biological Process (BP)response to organonitrogen compound1.22e-069.093e-10InformativeDirect
Biological Process (BP)lipid catabolic process9.29e-101.502e-06InformativeDirect
Biological Process (BP)regulation of lipid metabolic process1.628e-072.269e-05InformativeDirect
Biological Process (BP)hexose metabolic process7.676e-091.814e-05InformativeDirect
Biological Process (BP)muscle structure development2.451e-070.0003176InformativeDirect
Biological Process (BP)cellular response to nitrogen compound2.027e-081.169e-11InformativeDirect
Biological Process (BP)cellular response to oxygen-containing compound0.00019471.288e-06InformativeDirect
Biological Process (BP)cellular response to endogenous stimulus0.0067920.01553InformativeInherited
Biological Process (BP)muscle tissue development7.773e-120.01InformativeInherited
Biological Process (BP)regulation of intracellular protein kinase cascade0.086840.5717InformativeInherited
Biological Process (BP)regulation of kinase activity0.037871InformativeInherited
Biological Process (BP)positive regulation of signal transduction0.036490.2785InformativeInherited
Biological Process (BP)positive regulation of phosphate metabolic process1.892e-120.03396InformativeInherited
Biological Process (BP)positive regulation of protein metabolic process0.0010180.19InformativeInherited
Biological Process (BP)intracellular signal transduction0.0039130.7545InformativeInherited
Biological Process (BP)anatomical structure formation involved in morphogenesis0.0010980.3714InformativeInherited
Biological Process (BP)MAPK cascade1.454e-121.632e-07Highly InformativeDirect
Biological Process (BP)ER-nucleus signaling pathway3.75e-090.0001601Highly InformativeDirect
Biological Process (BP)transmembrane receptor protein tyrosine kinase signaling pathway00Highly InformativeDirect
Biological Process (BP)carbohydrate transport01.565e-11Highly InformativeDirect
Biological Process (BP)stress-activated protein kinase signaling cascade8.456e-104.082e-09Highly InformativeDirect
Biological Process (BP)response to endoplasmic reticulum stress6.255e-125.345e-07Highly InformativeDirect
Biological Process (BP)response to peptide hormone stimulus03.04e-08Highly InformativeDirect
Biological Process (BP)positive regulation of lipid metabolic process9.751e-082.029e-06Highly InformativeDirect
Biological Process (BP)regulation of binding5.169e-081.025e-06Highly InformativeDirect
Biological Process (BP)cellular response to biotic stimulus3.287e-103.478e-06Highly InformativeDirect
Biological Process (BP)regulation of cellular response to insulin stimulus2.575e-109.023e-09Highly InformativeDirect
Biological Process (BP)cellular response to peptide1.345e-073.186e-11Highly InformativeDirect
Biological Process (BP)intrinsic apoptotic signaling pathway4.635e-060.00199Highly InformativeInherited
Biological Process (BP)regulation of cellular response to stress6.248e-070.01031Highly InformativeInherited
Biological Process (BP)muscle organ development1.114e-060.01739Highly InformativeInherited
Biological Process (BP)regulation of MAP kinase activity0.0014050.7291Highly InformativeInherited
Biological Process (BP)positive regulation of MAPK cascade1.042e-120.4392Highly InformativeInherited
Biological Process (BP)positive regulation of protein kinase activity0.0032430.03909Highly InformativeInherited
Molecular Function (MF)binding0.00029089.448e-10Least InformativeDirect
Molecular Function (MF)receptor binding3.267e-090InformativeDirect
Molecular Function (MF)protein complex binding2.667e-093.094e-11Highly InformativeDirect
Cellular Component (CC)cytoplasmic part0.0046520.9508Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.37031Least InformativeInherited
Cellular Component (CC)vesicle3.001e-111.528e-06Moderately InformativeDirect
Cellular Component (CC)extracellular region part0.00025846.064e-12Moderately InformativeDirect
Cellular Component (CC)ribonucleoprotein complex7.91e-070.002788Moderately InformativeInherited
Cellular Component (CC)extracellular space4.594e-050InformativeDirect
Cellular Component (CC)secretory granule05.824e-15InformativeDirect
Cellular Component (CC)small nucleolar ribonucleoprotein complex5.276e-151.658e-12Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 9.231e-14 Least Informative Direct
Biological Process (BP) developmental process 6.334e-10 Least Informative Direct
Biological Process (BP) regulation of cellular process 0 Least Informative Direct
Biological Process (BP) biosynthetic process 0.4715 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.2946 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.03825 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.6931 Least Informative Inherited
Biological Process (BP) response to stimulus 0.00117 Least Informative Inherited
Biological Process (BP) localization 0.6745 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.2347 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.2309 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.8101 Least Informative Inherited
Biological Process (BP) reproduction 1.165e-10 Moderately Informative Direct
Biological Process (BP) sulfur compound metabolic process 1.056e-05 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 2.659e-08 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 3.834e-09 Moderately Informative Direct
Biological Process (BP) response to organic substance 3.204e-08 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 7.254e-05 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 9.913e-13 Moderately Informative Direct
Biological Process (BP) cell differentiation 1.143e-06 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of programmed cell death 0 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 4.085e-06 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 3.414e-06 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.0007577 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 1.08e-05 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 3.252e-05 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 1.322e-11 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.01536 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.008004 Moderately Informative Inherited
Biological Process (BP) tissue development 0.0946 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.1362 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.8559 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.005123 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.01231 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.002616 Moderately Informative Inherited
Biological Process (BP) organ development 0.001976 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.004161 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.09113 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.001089 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.4784 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.9055 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.008179 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.9089 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.01852 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.0468 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.00482 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.0002181 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 1.394e-10 Informative Direct
Biological Process (BP) cell death 3.032e-09 Informative Direct
Biological Process (BP) response to hormone stimulus 2.442e-09 Informative Direct
Biological Process (BP) response to organonitrogen compound 9.093e-10 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1.136e-06 Informative Direct
Biological Process (BP) lipid catabolic process 1.502e-06 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 2.269e-05 Informative Direct
Biological Process (BP) hexose metabolic process 1.814e-05 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 1.289e-07 Informative Direct
Biological Process (BP) regulation of organelle organization 1.57e-10 Informative Direct
Biological Process (BP) growth 3.991e-09 Informative Direct
Biological Process (BP) sulfur compound biosynthetic process 1.847e-07 Informative Direct
Biological Process (BP) reproductive structure development 2.949e-06 Informative Direct
Biological Process (BP) gland development 5.986e-06 Informative Direct
Biological Process (BP) positive regulation of transport 1.793e-06 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 4.581e-12 Informative Direct
Biological Process (BP) regulation of nervous system development 0.0001279 Informative Direct
Biological Process (BP) negative regulation of cell death 0 Informative Direct
Biological Process (BP) muscle structure development 0.0003176 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 1.169e-11 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 1.288e-06 Informative Direct
Biological Process (BP) regulation of apoptotic signaling pathway 7.619e-11 Informative Direct
Biological Process (BP) positive regulation of cell proliferation 0.00665 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.01872 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.01025 Informative Inherited
Biological Process (BP) organ morphogenesis 0.1218 Informative Inherited
Biological Process (BP) epithelium development 0.7317 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.1265 Informative Inherited
Biological Process (BP) cardiovascular system development 0.2494 Informative Inherited
Biological Process (BP) sensory organ development 0.06489 Informative Inherited
Biological Process (BP) response to wounding 0.01157 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.01768 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.01553 Informative Inherited
Biological Process (BP) muscle tissue development 0.01 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.2785 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.5717 Informative Inherited
Biological Process (BP) regulation of kinase activity 1 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.03396 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 0.19 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.7545 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.3714 Informative Inherited
Biological Process (BP) MAPK cascade 1.632e-07 Highly Informative Direct
Biological Process (BP) aminoglycan biosynthetic process 2.57e-11 Highly Informative Direct
Biological Process (BP) ER-nucleus signaling pathway 0.0001601 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0 Highly Informative Direct
Biological Process (BP) carbohydrate transport 1.565e-11 Highly Informative Direct
Biological Process (BP) glial cell differentiation 2.564e-06 Highly Informative Direct
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of mitochondrion organization 0 Highly Informative Direct
Biological Process (BP) glycosaminoglycan metabolic process 4.244e-10 Highly Informative Direct
Biological Process (BP) lung development 2.271e-05 Highly Informative Direct
Biological Process (BP) stress-activated protein kinase signaling cascade 4.082e-09 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 5.345e-07 Highly Informative Direct
Biological Process (BP) wound healing 0.0001224 Highly Informative Direct
Biological Process (BP) response to peptide hormone stimulus 3.04e-08 Highly Informative Direct
Biological Process (BP) positive regulation of lipid metabolic process 2.029e-06 Highly Informative Direct
Biological Process (BP) positive regulation of glucose import 0 Highly Informative Direct
Biological Process (BP) developmental growth 4.714e-07 Highly Informative Direct
Biological Process (BP) branching morphogenesis of an epithelial tube 3.035e-08 Highly Informative Direct
Biological Process (BP) inner ear development 0.0001137 Highly Informative Direct
Biological Process (BP) regulation of binding 1.025e-06 Highly Informative Direct
Biological Process (BP) regulation of protein kinase B signaling cascade 4.047e-05 Highly Informative Direct
Biological Process (BP) connective tissue development 9.338e-05 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 3.478e-06 Highly Informative Direct
Biological Process (BP) extrinsic apoptotic signaling pathway 5.644e-06 Highly Informative Direct
Biological Process (BP) regulation of cellular response to insulin stimulus 9.023e-09 Highly Informative Direct
Biological Process (BP) cellular response to peptide 3.186e-11 Highly Informative Direct
Biological Process (BP) regulation of neural precursor cell proliferation 9.796e-07 Highly Informative Direct
Biological Process (BP) regulation of ERK1 and ERK2 cascade 0.07855 Highly Informative Inherited
Biological Process (BP) intrinsic apoptotic signaling pathway 0.00199 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.01031 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.01739 Highly Informative Inherited
Biological Process (BP) regulation of MAP kinase activity 0.7291 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 0.4392 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 0.03909 Highly Informative Inherited
Molecular Function (MF) binding 9.448e-10 Least Informative Direct
Molecular Function (MF) receptor binding 0 Informative Direct
Molecular Function (MF) protein complex binding 3.094e-11 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.9508 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) vesicle 1.528e-06 Moderately Informative Direct
Cellular Component (CC) extracellular region part 6.064e-12 Moderately Informative Direct
Cellular Component (CC) ribonucleoprotein complex 0.002788 Moderately Informative Inherited
Cellular Component (CC) extracellular space 0 Informative Direct
Cellular Component (CC) secretory granule 5.824e-15 Informative Direct
Cellular Component (CC) small nucleolar ribonucleoprotein complex 1.658e-12 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0Least InformativeDirect
Disease Ontology (DO)nervous system disease0.4372Least InformativeInherited
Disease Ontology (DO)cell type cancer0Moderately InformativeDirect
Disease Ontology (DO)artery disease0Moderately InformativeDirect
Disease Ontology (DO)disease of metabolism0.0004398Moderately InformativeDirect
Disease Ontology (DO)endocrine system disease0.000578Moderately InformativeDirect
Disease Ontology (DO)lung disease0.006726Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.01751Moderately InformativeInherited
Disease Ontology (DO)syndrome0.01918Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.1153Moderately InformativeInherited
Disease Ontology (DO)hypertension0InformativeDirect
Disease Ontology (DO)overnutrition3.386e-05InformativeDirect
Disease Ontology (DO)in situ carcinoma9.055e-05InformativeDirect
Disease Ontology (DO)motor neuron disease0.0001252InformativeDirect
Disease Ontology (DO)endocrine gland cancer0.00186InformativeInherited
Disease Ontology (DO)liver disease0.00579InformativeInherited
Disease Ontology (DO)pancreas disease0.1208InformativeInherited
Disease Ontology (DO)hyperandrogenism1.122e-07Highly InformativeDirect
Disease Ontology (DO)polycystic ovary syndrome1.021e-06Highly InformativeDirect
Disease Ontology (DO)interstitial lung disease0.0001096Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.04679Least InformativeInherited
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal skeleton morphology0.007674Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.1705Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal male germ cell morphology0.0009386InformativeDirect
Mammalian Phenotype (MP)abnormal prenatal growth/weight/body size0.02148InformativeInherited
Mammalian Phenotype (MP)abnormal circulating glucose level0.02151InformativeInherited
Mammalian Phenotype (MP)abnormal sex determination0.0992InformativeInherited
Mammalian Phenotype (MP)abnormal bone structure0.2395InformativeInherited
Mammalian Phenotype (MP)decreased birth weight1.63e-06Highly InformativeDirect
Mammalian Phenotype (MP)decreased fetal size0.0005686Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pancreatic islet morphology0.0006973Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.0002272Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.05851Least InformativeInherited
Worm Phenotype (WP)locomotion variant1.298e-05Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant9.153e-05Moderately InformativeDirect
Worm Phenotype (WP)lipid metabolism variant0.0003172InformativeDirect
Worm Phenotype (WP)body length variant0.0004554InformativeDirect
Worm Phenotype (WP)body width variant0.0006215InformativeDirect
Worm Phenotype (WP)dauer development variant1.519e-10Highly InformativeDirect
Worm Phenotype (WP)dauer arrest variant8.647e-10Highly InformativeDirect
Worm Phenotype (WP)small2.592e-06Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)mating defective9.081e-05InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)alimentary system0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)liver and biliary system0InformativeDirect
Xenopus DEvelopment stage (XDE)embryonic stage0Least InformativeDirect
Xenopus DEvelopment stage (XDE)NF stage0Least InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processGlucose metabolism0Highly InformativeDirect
Biological processOsteogenesis0Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
DomainSignal0Least InformativeDirect
Post-translational modificationGrowth factor0InformativeDirect
Post-translational modificationHormone0Highly InformativeDirect
Post-translational modificationMitogen0Highly InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues0Moderately InformativeDirect
Post-translational modificationPyrrolidone carboxylic acid0InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 11 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Insulin-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 11 hidden Markov models representing the Insulin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]