SUPERFAMILY 1.75 HMM library and genome assignments server

Aerolisin/ETX pore-forming domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Aerolisin/ETX pore-forming domain [ 56972]
Superfamily:   Aerolisin/ETX pore-forming domain [ 56973] (2)
Families:   (Pro)aerolysin, pore-forming lobe [ 56974]
  ETX/MTX2 [ 111375]

Superfamily statistics
Genomes (164) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 490 1,139 4
Proteins 490 1,139 4

Functional annotation
General category Other
Detailed category Unknown function

Function annotation of SCOP domain superfamilies

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCytolysis0InformativeDirect
Cellular componentMembrane0.002425Least InformativeInherited
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentHost membrane8.763e-11InformativeDirect
DomainSignal3.975e-06Least InformativeDirect
DomainTransmembrane0.06139Least InformativeInherited
DomainTransmembrane beta strand5.521e-12InformativeDirect
Post-translational modificationToxin0InformativeDirect
Post-translational modificationDisulfide bond2.896e-12Least InformativeDirect

Document: KW annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a Aerolisin/ETX pore-forming domain domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Aerolisin/ETX pore-forming domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

Jump to [ Top of page · SCOP classification · Functional annotation · UniProtKB KeyWords (KW) · Internal database links ]