SUPERFAMILY 1.75 HMM library and genome assignments server


Bcl-2 inhibitors of programmed cell death superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Toxins' membrane translocation domains [ 56836] (5)
Superfamily:   Bcl-2 inhibitors of programmed cell death [ 56854]
Families:   Bcl-2 inhibitors of programmed cell death [ 56855] (10)


Superfamily statistics
Genomes (140) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,230 1,590 29
Proteins 1,222 1,582 29


Functional annotation
General category Processes_IC
Detailed category Cell cycle, Apoptosis

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process3.664e-123.942e-05Least InformativeDirect
Biological Process (BP)developmental process2.615e-114.102e-05Least InformativeDirect
Biological Process (BP)single-organism cellular process00Least InformativeDirect
Biological Process (BP)regulation of cellular process00Least InformativeDirect
Biological Process (BP)response to stimulus01.669e-13Least InformativeDirect
Biological Process (BP)localization1.826e-086.117e-05Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis08.03e-11Least InformativeDirect
Biological Process (BP)regulation of metabolic process0.13450.7753Least InformativeInherited
Biological Process (BP)reproduction00Moderately InformativeDirect
Biological Process (BP)immune system process2.005e-101.147e-06Moderately InformativeDirect
Biological Process (BP)organelle organization3.258e-152.509e-09Moderately InformativeDirect
Biological Process (BP)signal transduction6.933e-113.224e-10Moderately InformativeDirect
Biological Process (BP)response to abiotic stimulus5.329e-061.275e-05Moderately InformativeDirect
Biological Process (BP)cell differentiation8.894e-142.848e-08Moderately InformativeDirect
Biological Process (BP)cellular response to stress3.597e-091.95e-10Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process2.021e-061.261e-05Moderately InformativeDirect
Biological Process (BP)regulation of catalytic activity1.919e-120Moderately InformativeDirect
Biological Process (BP)regulation of protein metabolic process1.103e-050.0002148Moderately InformativeDirect
Biological Process (BP)multi-organism process1.072e-072.841e-05Moderately InformativeDirect
Biological Process (BP)regulation of biological quality6.484e-123.351e-10Moderately InformativeDirect
Biological Process (BP)positive regulation of response to stimulus0.02060.0001511Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction2.48e-050.0282Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.5510.502Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.94861Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.87840.9643Moderately InformativeInherited
Biological Process (BP)cellular localization0.0087540.07849Moderately InformativeInherited
Biological Process (BP)tissue development0.26640.7944Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.0060110.05244Moderately InformativeInherited
Biological Process (BP)response to organic substance0.58230.7404Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization0.93930.6735Moderately InformativeInherited
Biological Process (BP)cellular component biogenesis11Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.0043650.07876Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.00026880.1527Moderately InformativeInherited
Biological Process (BP)organ development6.754e-060.01473Moderately InformativeInherited
Biological Process (BP)regulation of developmental process11Moderately InformativeInherited
Biological Process (BP)regulation of localization0.15540.252Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.00073720.03022Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process8.316e-050.002241Moderately InformativeInherited
Biological Process (BP)ion transport0.003620.01197Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process10.0001015Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.94461Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function0.0015930.02146Moderately InformativeInherited
Biological Process (BP)regulation of protein phosphorylation5.438e-101.549e-06InformativeDirect
Biological Process (BP)developmental process involved in reproduction3.046e-124.763e-14InformativeDirect
Biological Process (BP)apoptotic process00InformativeDirect
Biological Process (BP)mitochondrion organization00InformativeDirect
Biological Process (BP)response to organic cyclic compound3.015e-062.294e-05InformativeDirect
Biological Process (BP)cellular membrane organization00InformativeDirect
Biological Process (BP)response to nutrient levels0.00046061.244e-06InformativeDirect
Biological Process (BP)regulation of intracellular transport1.568e-095.82e-10InformativeDirect
Biological Process (BP)regulation of organelle organization1.627e-062.744e-05InformativeDirect
Biological Process (BP)tube development1.052e-050.0001476InformativeDirect
Biological Process (BP)intracellular signal transduction2.83e-089.875e-10InformativeDirect
Biological Process (BP)growth2.55e-060.0004365InformativeDirect
Biological Process (BP)regulation of apoptotic process00InformativeDirect
Biological Process (BP)regulation of ion transport3.402e-051.459e-05InformativeDirect
Biological Process (BP)regulation of cellular component biogenesis6.174e-060.0001702InformativeDirect
Biological Process (BP)single organism reproductive process3.567e-092.666e-05InformativeDirect
Biological Process (BP)leukocyte activation6.967e-086.351e-07InformativeDirect
Biological Process (BP)hematopoietic or lymphoid organ development3.937e-063.038e-05InformativeDirect
Biological Process (BP)cellular process involved in reproduction5.349e-112.681e-09InformativeDirect
Biological Process (BP)positive regulation of cellular component organization3.102e-067.662e-05InformativeDirect
Biological Process (BP)protein oligomerization3.201e-082.142e-07InformativeDirect
Biological Process (BP)positive regulation of hydrolase activity1.514e-060.0002146InformativeDirect
Biological Process (BP)regulation of peptidase activity00InformativeDirect
Biological Process (BP)cation homeostasis1.101e-141.603e-11InformativeDirect
Biological Process (BP)transmembrane transport1.668e-062.343e-07InformativeDirect
Biological Process (BP)epithelium development2.657e-097.826e-05InformativeDirect
Biological Process (BP)negative regulation of cell death3.12e-081.931e-15InformativeDirect
Biological Process (BP)reproductive system development00InformativeDirect
Biological Process (BP)positive regulation of signal transduction0.0024230.02201InformativeInherited
Biological Process (BP)tissue morphogenesis9.957e-050.00392InformativeInherited
Biological Process (BP)cardiovascular system development0.037670.05149InformativeInherited
Biological Process (BP)regulation of mitotic cell cycle0.72020.8351InformativeInherited
Biological Process (BP)regulation of cell cycle process0.96971InformativeInherited
Biological Process (BP)protein localization to organelle0.026510.0248InformativeInherited
Biological Process (BP)cellular chemical homeostasis0.00076170.04047InformativeInherited
Biological Process (BP)cellular response to endogenous stimulus0.79550.9929InformativeInherited
Biological Process (BP)response to organonitrogen compound0.003430.009364InformativeInherited
Biological Process (BP)cellular response to nitrogen compound0.0027360.00893InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound0.25030.1853InformativeInherited
Biological Process (BP)response to other organism0.042850.0537InformativeInherited
Biological Process (BP)response to hormone stimulus0.65350.6554InformativeInherited
Biological Process (BP)response to lipid0.54370.4756InformativeInherited
Biological Process (BP)response to wounding0.5440.8186InformativeInherited
Biological Process (BP)sensory organ development6.937e-050.004156InformativeInherited
Biological Process (BP)organ morphogenesis0.0033840.1544InformativeInherited
Biological Process (BP)positive regulation of developmental process0.54770.736InformativeInherited
Biological Process (BP)positive regulation of transport0.20590.1912InformativeInherited
Biological Process (BP)embryo development ending in birth or egg hatching0.075620.04348InformativeInherited
Biological Process (BP)negative regulation of protein metabolic process0.0050350.0002412InformativeInherited
Biological Process (BP)cellular component morphogenesis0.0028490.1527InformativeInherited
Biological Process (BP)regulation of cellular catabolic process0.35370.00055InformativeInherited
Biological Process (BP)response to light stimulus11InformativeInherited
Biological Process (BP)response to DNA damage stimulus0.038910.06596InformativeInherited
Biological Process (BP)multicellular organismal reproductive process0.060110.5232InformativeInherited
Biological Process (BP)sexual reproduction0.10290.5542InformativeInherited
Biological Process (BP)anatomical structure formation involved in morphogenesis0.019510.1833InformativeInherited
Biological Process (BP)cell cycle process0.51180.94InformativeInherited
Biological Process (BP)angiogenesis6.058e-052.926e-05Highly InformativeDirect
Biological Process (BP)leukocyte homeostasis00Highly InformativeDirect
Biological Process (BP)mitochondrial transport00Highly InformativeDirect
Biological Process (BP)cellular calcium ion homeostasis00Highly InformativeDirect
Biological Process (BP)mitochondrial membrane organization7.13e-099.788e-12Highly InformativeDirect
Biological Process (BP)spermatogenesis3.258e-151.398e-10Highly InformativeDirect
Biological Process (BP)gonad development00Highly InformativeDirect
Biological Process (BP)response to UV1.294e-121.66e-10Highly InformativeDirect
Biological Process (BP)fertilization1.101e-051.022e-06Highly InformativeDirect
Biological Process (BP)response to virus9.59e-050.0002097Highly InformativeDirect
Biological Process (BP)response to toxic substance00Highly InformativeDirect
Biological Process (BP)response to ionizing radiation4.944e-138.767e-14Highly InformativeDirect
Biological Process (BP)regulation of autophagy2.311e-052.458e-07Highly InformativeDirect
Biological Process (BP)positive regulation of organelle organization1.051e-092.682e-09Highly InformativeDirect
Biological Process (BP)regulation of mitochondrion organization00Highly InformativeDirect
Biological Process (BP)positive regulation of endopeptidase activity8.099e-115.607e-05Highly InformativeDirect
Biological Process (BP)cellular process involved in reproduction in multicellular organism3.878e-051.137e-05Highly InformativeDirect
Biological Process (BP)ovulation cycle process00Highly InformativeDirect
Biological Process (BP)negative regulation of protein modification process0.00068960.0004548Highly InformativeDirect
Biological Process (BP)positive regulation of homeostatic process2.503e-066.291e-07Highly InformativeDirect
Biological Process (BP)cell part morphogenesis6.381e-151.298e-07Highly InformativeDirect
Biological Process (BP)response to endoplasmic reticulum stress03.287e-14Highly InformativeDirect
Biological Process (BP)limb morphogenesis4.637e-143.27e-09Highly InformativeDirect
Biological Process (BP)modification of morphology or physiology of other organism4.983e-061.37e-05Highly InformativeDirect
Biological Process (BP)B cell activation8.092e-053.009e-05Highly InformativeDirect
Biological Process (BP)negative regulation of phosphorylation0.00045220.0002692Highly InformativeDirect
Biological Process (BP)regulation of membrane potential02.284e-14Highly InformativeDirect
Biological Process (BP)positive regulation of programmed cell death2.189e-070.0001689Highly InformativeDirect
Biological Process (BP)response to amino acid stimulus1.085e-079.62e-08Highly InformativeDirect
Biological Process (BP)regulation of protein complex assembly9.152e-073.099e-08Highly InformativeDirect
Biological Process (BP)positive regulation of ion transport0.00016987.029e-05Highly InformativeDirect
Biological Process (BP)response to alkaloid1.589e-098.687e-09Highly InformativeDirect
Biological Process (BP)regulation of cysteine-type endopeptidase activity involved in apoptotic process6.077e-103.947e-11Highly InformativeDirect
Biological Process (BP)regulation of neuron apoptotic process0.0006940.0001795Highly InformativeDirect
Biological Process (BP)symbiosis, encompassing mutualism through parasitism5.828e-119.021e-09Highly InformativeDirect
Biological Process (BP)multi-organism cellular process3.728e-078.059e-06Highly InformativeDirect
Biological Process (BP)development of primary female sexual characteristics0.00029252.183e-06Highly InformativeDirect
Biological Process (BP)organelle fusion3.258e-150Highly InformativeDirect
Biological Process (BP)eye morphogenesis1.795e-054.701e-05Highly InformativeDirect
Biological Process (BP)response to axon injury5.983e-104.59e-10Highly InformativeDirect
Biological Process (BP)branching morphogenesis of an epithelial tube01.028e-12Highly InformativeDirect
Biological Process (BP)regulation of binding5.345e-082.96e-06Highly InformativeDirect
Biological Process (BP)protein homooligomerization4.426e-098.236e-09Highly InformativeDirect
Biological Process (BP)response to glucocorticoid stimulus1.965e-072.495e-07Highly InformativeDirect
Biological Process (BP)regulation of calcium ion transport00Highly InformativeDirect
Biological Process (BP)protein localization to mitochondrion7.844e-086.074e-08Highly InformativeDirect
Biological Process (BP)cellular response to radiation1.278e-053.814e-05Highly InformativeDirect
Biological Process (BP)regulation of cellular response to stress1.62e-071.124e-09Highly InformativeDirect
Biological Process (BP)extrinsic apoptotic signaling pathway00Highly InformativeDirect
Biological Process (BP)intrinsic apoptotic signaling pathway00Highly InformativeDirect
Biological Process (BP)cell-type specific apoptotic process9.042e-126.684e-09Highly InformativeDirect
Biological Process (BP)regulation of ion homeostasis00Highly InformativeDirect
Biological Process (BP)positive regulation of apoptotic signaling pathway7.888e-132.782e-14Highly InformativeDirect
Biological Process (BP)regulation of intrinsic apoptotic signaling pathway0.00060552.042e-05Highly InformativeDirect
Biological Process (BP)pattern specification process6.986e-060.004894Highly InformativeInherited
Biological Process (BP)establishment of protein localization to organelle0.0012930.002298Highly InformativeInherited
Biological Process (BP)post-embryonic organ development1.089e-050.003647Highly InformativeInherited
Biological Process (BP)post-embryonic development2.719e-050.002367Highly InformativeInherited
Biological Process (BP)positive regulation of intracellular transport0.007630.002712Highly InformativeInherited
Biological Process (BP)membrane fusion0.0028720.0002264Highly InformativeInherited
Biological Process (BP)cell division0.01120.05932Highly InformativeInherited
Molecular Function (MF)binding01.731e-12Least InformativeDirect
Molecular Function (MF)transporter activity8.87e-073.977e-06Moderately InformativeDirect
Molecular Function (MF)enzyme regulator activity0.026260.005748Moderately InformativeInherited
Molecular Function (MF)lipid binding2.022e-067.747e-07InformativeDirect
Molecular Function (MF)protein dimerization activity00InformativeDirect
Molecular Function (MF)peptidase regulator activity0.00035867.824e-05InformativeDirect
Molecular Function (MF)protein domain specific binding00Highly InformativeDirect
Molecular Function (MF)cysteine-type endopeptidase regulator activity involved in apoptotic process2.977e-073.133e-08Highly InformativeDirect
Molecular Function (MF)protein heterodimerization activity03.303e-11Highly InformativeDirect
Cellular Component (CC)membrane00Least InformativeDirect
Cellular Component (CC)cytoplasmic part3.728e-090Least InformativeDirect
Cellular Component (CC)intracellular organelle part1.638e-142.563e-08Least InformativeDirect
Cellular Component (CC)protein complex5.523e-060.003164Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.0093860.009334Least InformativeInherited
Cellular Component (CC)intracellular non-membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)endoplasmic reticulum1.434e-123.367e-11Moderately InformativeDirect
Cellular Component (CC)cytosol3.157e-061.103e-06Moderately InformativeDirect
Cellular Component (CC)endomembrane system2.174e-091.412e-07Moderately InformativeDirect
Cellular Component (CC)organelle membrane00Moderately InformativeDirect
Cellular Component (CC)intrinsic to membrane6.205e-072.114e-05Moderately InformativeDirect
Cellular Component (CC)organelle envelope00Moderately InformativeDirect
Cellular Component (CC)mitochondrial part00Moderately InformativeDirect
Cellular Component (CC)cytoskeleton0.20180.2489Moderately InformativeInherited
Cellular Component (CC)endoplasmic reticulum membrane4.09e-063.333e-06InformativeDirect
Cellular Component (CC)integral to membrane01.592e-13InformativeDirect
Cellular Component (CC)microtubule cytoskeleton0.0012040.03142InformativeInherited
Cellular Component (CC)centrosome2.165e-050.0001177Highly InformativeDirect
Cellular Component (CC)organelle outer membrane00Highly InformativeDirect
Cellular Component (CC)pore complex00Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 3.942e-05 Least Informative Direct
Biological Process (BP) developmental process 4.102e-05 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 0 Least Informative Direct
Biological Process (BP) response to stimulus 1.669e-13 Least Informative Direct
Biological Process (BP) localization 6.117e-05 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 8.03e-11 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.7753 Least Informative Inherited
Biological Process (BP) reproduction 0 Moderately Informative Direct
Biological Process (BP) immune system process 1.147e-06 Moderately Informative Direct
Biological Process (BP) organelle organization 2.509e-09 Moderately Informative Direct
Biological Process (BP) signal transduction 3.224e-10 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 1.275e-05 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0.0001015 Moderately Informative Direct
Biological Process (BP) cell differentiation 2.848e-08 Moderately Informative Direct
Biological Process (BP) cellular response to stress 1.95e-10 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 1.261e-05 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 0.0001511 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.0002148 Moderately Informative Direct
Biological Process (BP) multi-organism process 2.841e-05 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 3.351e-10 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.0282 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.502 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.9643 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.07849 Moderately Informative Inherited
Biological Process (BP) tissue development 0.7944 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.05244 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.7404 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.6735 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.07876 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.1527 Moderately Informative Inherited
Biological Process (BP) organ development 0.01473 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.002241 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.252 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.03022 Moderately Informative Inherited
Biological Process (BP) ion transport 0.01197 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.02146 Moderately Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 1.549e-06 Informative Direct
Biological Process (BP) developmental process involved in reproduction 4.763e-14 Informative Direct
Biological Process (BP) apoptotic process 0 Informative Direct
Biological Process (BP) mitochondrion organization 0 Informative Direct
Biological Process (BP) response to organic cyclic compound 2.294e-05 Informative Direct
Biological Process (BP) cellular membrane organization 0 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0.00055 Informative Direct
Biological Process (BP) response to nutrient levels 1.244e-06 Informative Direct
Biological Process (BP) regulation of intracellular transport 5.82e-10 Informative Direct
Biological Process (BP) regulation of organelle organization 2.744e-05 Informative Direct
Biological Process (BP) tube development 0.0001476 Informative Direct
Biological Process (BP) intracellular signal transduction 9.875e-10 Informative Direct
Biological Process (BP) growth 0.0004365 Informative Direct
Biological Process (BP) regulation of apoptotic process 0 Informative Direct
Biological Process (BP) regulation of ion transport 1.459e-05 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.0001702 Informative Direct
Biological Process (BP) single organism reproductive process 2.666e-05 Informative Direct
Biological Process (BP) leukocyte activation 6.351e-07 Informative Direct
Biological Process (BP) hematopoietic or lymphoid organ development 3.038e-05 Informative Direct
Biological Process (BP) cellular process involved in reproduction 2.681e-09 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 7.662e-05 Informative Direct
Biological Process (BP) negative regulation of protein metabolic process 0.0002412 Informative Direct
Biological Process (BP) protein oligomerization 2.142e-07 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.0002146 Informative Direct
Biological Process (BP) regulation of peptidase activity 0 Informative Direct
Biological Process (BP) cation homeostasis 1.603e-11 Informative Direct
Biological Process (BP) transmembrane transport 2.343e-07 Informative Direct
Biological Process (BP) epithelium development 7.826e-05 Informative Direct
Biological Process (BP) negative regulation of cell death 1.931e-15 Informative Direct
Biological Process (BP) reproductive system development 0 Informative Direct
Biological Process (BP) positive regulation of signal transduction 0.02201 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.7598 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.5979 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.8988 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.00392 Informative Inherited
Biological Process (BP) cardiovascular system development 0.05149 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.8351 Informative Inherited
Biological Process (BP) regulation of cell cycle process 1 Informative Inherited
Biological Process (BP) protein localization to organelle 0.0248 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.04047 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.9929 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.009364 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.00893 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.1853 Informative Inherited
Biological Process (BP) response to other organism 0.0537 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.6554 Informative Inherited
Biological Process (BP) response to lipid 0.4756 Informative Inherited
Biological Process (BP) response to wounding 0.8186 Informative Inherited
Biological Process (BP) sensory organ development 0.004156 Informative Inherited
Biological Process (BP) organ morphogenesis 0.1544 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.736 Informative Inherited
Biological Process (BP) positive regulation of transport 0.1912 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.04348 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.1527 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.4203 Informative Inherited
Biological Process (BP) response to light stimulus 1 Informative Inherited
Biological Process (BP) response to DNA damage stimulus 0.06596 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.5232 Informative Inherited
Biological Process (BP) sexual reproduction 0.5542 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.1833 Informative Inherited
Biological Process (BP) cell cycle process 0.94 Informative Inherited
Biological Process (BP) angiogenesis 2.926e-05 Highly Informative Direct
Biological Process (BP) leukocyte homeostasis 0 Highly Informative Direct
Biological Process (BP) mitochondrial transport 0 Highly Informative Direct
Biological Process (BP) cellular calcium ion homeostasis 0 Highly Informative Direct
Biological Process (BP) mitochondrial membrane organization 9.788e-12 Highly Informative Direct
Biological Process (BP) spermatogenesis 1.398e-10 Highly Informative Direct
Biological Process (BP) gonad development 0 Highly Informative Direct
Biological Process (BP) response to UV 1.66e-10 Highly Informative Direct
Biological Process (BP) fertilization 1.022e-06 Highly Informative Direct
Biological Process (BP) response to virus 0.0002097 Highly Informative Direct
Biological Process (BP) response to toxic substance 0 Highly Informative Direct
Biological Process (BP) positive regulation of catabolic process 2.256e-05 Highly Informative Direct
Biological Process (BP) response to ionizing radiation 8.767e-14 Highly Informative Direct
Biological Process (BP) regulation of autophagy 2.458e-07 Highly Informative Direct
Biological Process (BP) positive regulation of organelle organization 2.682e-09 Highly Informative Direct
Biological Process (BP) regulation of mitochondrion organization 0 Highly Informative Direct
Biological Process (BP) positive regulation of endopeptidase activity 5.607e-05 Highly Informative Direct
Biological Process (BP) cellular process involved in reproduction in multicellular organism 1.137e-05 Highly Informative Direct
Biological Process (BP) ovulation cycle process 0 Highly Informative Direct
Biological Process (BP) negative regulation of protein modification process 0.0004548 Highly Informative Direct
Biological Process (BP) positive regulation of homeostatic process 6.291e-07 Highly Informative Direct
Biological Process (BP) cell part morphogenesis 1.298e-07 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 3.287e-14 Highly Informative Direct
Biological Process (BP) limb morphogenesis 3.27e-09 Highly Informative Direct
Biological Process (BP) modification of morphology or physiology of other organism 1.37e-05 Highly Informative Direct
Biological Process (BP) B cell activation 3.009e-05 Highly Informative Direct
Biological Process (BP) negative regulation of phosphorylation 0.0002692 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 2.284e-14 Highly Informative Direct
Biological Process (BP) positive regulation of programmed cell death 0.0001689 Highly Informative Direct
Biological Process (BP) response to amino acid stimulus 9.62e-08 Highly Informative Direct
Biological Process (BP) regulation of protein complex assembly 3.099e-08 Highly Informative Direct
Biological Process (BP) positive regulation of ion transport 7.029e-05 Highly Informative Direct
Biological Process (BP) response to alkaloid 8.687e-09 Highly Informative Direct
Biological Process (BP) regulation of cysteine-type endopeptidase activity involved in apoptotic process 3.947e-11 Highly Informative Direct
Biological Process (BP) regulation of neuron apoptotic process 0.0001795 Highly Informative Direct
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 9.021e-09 Highly Informative Direct
Biological Process (BP) multi-organism cellular process 8.059e-06 Highly Informative Direct
Biological Process (BP) development of primary female sexual characteristics 2.183e-06 Highly Informative Direct
Biological Process (BP) organelle fusion 0 Highly Informative Direct
Biological Process (BP) eye morphogenesis 4.701e-05 Highly Informative Direct
Biological Process (BP) response to axon injury 4.59e-10 Highly Informative Direct
Biological Process (BP) branching morphogenesis of an epithelial tube 1.028e-12 Highly Informative Direct
Biological Process (BP) regulation of binding 2.96e-06 Highly Informative Direct
Biological Process (BP) protein homooligomerization 8.236e-09 Highly Informative Direct
Biological Process (BP) response to glucocorticoid stimulus 2.495e-07 Highly Informative Direct
Biological Process (BP) regulation of calcium ion transport 0 Highly Informative Direct
Biological Process (BP) membrane fusion 0.0002264 Highly Informative Direct
Biological Process (BP) protein localization to mitochondrion 6.074e-08 Highly Informative Direct
Biological Process (BP) cellular response to radiation 3.814e-05 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 1.124e-09 Highly Informative Direct
Biological Process (BP) extrinsic apoptotic signaling pathway 0 Highly Informative Direct
Biological Process (BP) intrinsic apoptotic signaling pathway 0 Highly Informative Direct
Biological Process (BP) cell-type specific apoptotic process 6.684e-09 Highly Informative Direct
Biological Process (BP) regulation of ion homeostasis 0 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic signaling pathway 0.00011 Highly Informative Direct
Biological Process (BP) positive regulation of apoptotic signaling pathway 2.782e-14 Highly Informative Direct
Biological Process (BP) regulation of intrinsic apoptotic signaling pathway 2.042e-05 Highly Informative Direct
Biological Process (BP) pattern specification process 0.004894 Highly Informative Inherited
Biological Process (BP) establishment of protein localization to organelle 0.002298 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.003647 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.002367 Highly Informative Inherited
Biological Process (BP) positive regulation of response to external stimulus 0.0421 Highly Informative Inherited
Biological Process (BP) regulation of response to nutrient levels 1 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.002712 Highly Informative Inherited
Biological Process (BP) cell division 0.05932 Highly Informative Inherited
Molecular Function (MF) binding 1.731e-12 Least Informative Direct
Molecular Function (MF) transporter activity 3.977e-06 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0.005748 Moderately Informative Inherited
Molecular Function (MF) lipid binding 7.747e-07 Informative Direct
Molecular Function (MF) protein dimerization activity 0 Informative Direct
Molecular Function (MF) peptidase regulator activity 7.824e-05 Informative Direct
Molecular Function (MF) protein domain specific binding 0 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 3.133e-08 Highly Informative Direct
Molecular Function (MF) protein heterodimerization activity 3.303e-11 Highly Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 2.563e-08 Least Informative Direct
Cellular Component (CC) protein complex 0.003164 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.009334 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 3.367e-11 Moderately Informative Direct
Cellular Component (CC) cytosol 1.103e-06 Moderately Informative Direct
Cellular Component (CC) endomembrane system 1.412e-07 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 2.114e-05 Moderately Informative Direct
Cellular Component (CC) organelle envelope 0 Moderately Informative Direct
Cellular Component (CC) mitochondrial part 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.2489 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 3.333e-06 Informative Direct
Cellular Component (CC) integral to membrane 1.592e-13 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.03142 Informative Inherited
Cellular Component (CC) centrosome 0.0001177 Highly Informative Direct
Cellular Component (CC) organelle outer membrane 0 Highly Informative Direct
Cellular Component (CC) pore complex 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.002121Least InformativeInherited
Disease Ontology (DO)leukemia0.001873Moderately InformativeInherited
Disease Ontology (DO)chronic leukemia0.04311InformativeInherited
Disease Ontology (DO)lymphoblastic leukemia0.08496InformativeInherited
Disease Ontology (DO)viral infectious disease0.1316InformativeInherited
Disease Ontology (DO)chronic lymphocytic leukemia5.177e-05Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.01089Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.01667Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.07787Least InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.0008378Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal immune system organ morphology0.0009069Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal tumor incidence0.001307Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukopoiesis0.002852Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.004311Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lymphocyte morphology0.01014Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.02511Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell morphology0.06653Moderately InformativeInherited
Mammalian Phenotype (MP)renal/urinary system phenotype0.09154Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.1737Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune cell physiology0.1832Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell-mediated immunity0.1882Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive immunity0.1992Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell physiology0.8225Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal metencephalon morphology8.427e-05InformativeDirect
Mammalian Phenotype (MP)abnormal mature B cell morphology0.000431InformativeDirect
Mammalian Phenotype (MP)abnormal B cell physiology0.0005339InformativeDirect
Mammalian Phenotype (MP)abnormal internal female genitalia morphology0.0006204InformativeDirect
Mammalian Phenotype (MP)decreased germ cell number0.001032InformativeInherited
Mammalian Phenotype (MP)abnormal T cell morphology0.003029InformativeInherited
Mammalian Phenotype (MP)abnormal renal glomerulus morphology0.004345InformativeInherited
Mammalian Phenotype (MP)decreased leukocyte cell number0.004766InformativeInherited
Mammalian Phenotype (MP)abnormal lymphocyte cell number0.004986InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.06604InformativeInherited
Mammalian Phenotype (MP)abnormal lymph node morphology0.2224InformativeInherited
Mammalian Phenotype (MP)abnormal sex gland morphology0.3007InformativeInherited
Mammalian Phenotype (MP)abnormal lymph organ size0.3739InformativeInherited
Mammalian Phenotype (MP)abnormal gametes0.5154InformativeInherited
Mammalian Phenotype (MP)abnormal immature B cell morphology2.119e-05Highly InformativeDirect
Mammalian Phenotype (MP)decreased mature B cell number0.000155Highly InformativeDirect
Mammalian Phenotype (MP)abnormal autonomic nervous system morphology0.0005783Highly InformativeDirect
Mammalian Phenotype (MP)enlarged lymph nodes0.0008679Highly InformativeDirect
Mammalian Phenotype (MP)abnormal immune organ physiology0.00729Highly InformativeInherited

Document: MP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0Moderately InformativeDirect
Biological processHost-virus interaction3.447e-10Moderately InformativeDirect
Biological processDifferentiation0.0001673Moderately InformativeDirect
Biological processModulation of host cell apoptosis by virus0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus1.269e-07Least InformativeDirect
Cellular componentCytoplasm0.9418Least InformativeInherited
Cellular componentMitochondrion0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle7.959e-06Moderately InformativeDirect
Cellular componentCell junction1.64e-05Moderately InformativeDirect
Cellular componentEndoplasmic reticulum2.457e-05Moderately InformativeDirect
Cellular componentCytoskeleton0.000633Moderately InformativeDirect
Cellular componentMitochondrion outer membrane4.246e-08InformativeDirect
Cellular componentSynapse2.548e-07InformativeDirect
DomainTransmembrane0Least InformativeDirect
Post-translational modificationDevelopmental protein0.0005994Moderately InformativeDirect
Post-translational modificationPhosphoprotein1.427e-05Least InformativeDirect
Post-translational modificationUbl conjugation1.173e-10Moderately InformativeDirect
Post-translational modificationIsopeptide bond0.0009855Moderately InformativeDirect

Document: KW annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 13 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Bcl-2 inhibitors of programmed cell death domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 13 hidden Markov models representing the Bcl-2 inhibitors of programmed cell death superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]