SUPERFAMILY 1.75 HMM library and genome assignments server

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Bcl-2 inhibitors of programmed cell death superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Toxins' membrane translocation domains [ 56836] (5)
Superfamily:   Bcl-2 inhibitors of programmed cell death [ 56854]
Families:   Bcl-2 inhibitors of programmed cell death [ 56855] (10)


Superfamily statistics
Genomes (140) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,230 1,590 29
Proteins 1,222 1,582 29


Functional annotation
General category Processes_IC
Detailed category Cell cycle, Apoptosis

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process0.0000000000038480.00004013Least InformativeDirect
Biological Process (BP)developmental process0.000000000027840.00004128Least InformativeDirect
Biological Process (BP)single-organism cellular process00Least InformativeDirect
Biological Process (BP)regulation of cellular process00Least InformativeDirect
Biological Process (BP)response to stimulus00.0000000000001873Least InformativeDirect
Biological Process (BP)localization0.000000019490.000067Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis00.0000000000959Least InformativeDirect
Biological Process (BP)regulation of metabolic process0.13070.7869Least InformativeInherited
Biological Process (BP)reproduction00Moderately InformativeDirect
Biological Process (BP)immune system process0.0000000002010.000001152Moderately InformativeDirect
Biological Process (BP)organelle organization0.0000000000000032610.000000002518Moderately InformativeDirect
Biological Process (BP)signal transduction0.000000000052560.0000000002598Moderately InformativeDirect
Biological Process (BP)response to abiotic stimulus0.000005430.00001305Moderately InformativeDirect
Biological Process (BP)cell differentiation0.000000000000087830.0000000292Moderately InformativeDirect
Biological Process (BP)cellular response to stress0.0000000035460.0000000002315Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process0.0000024080.00001634Moderately InformativeDirect
Biological Process (BP)regulation of catalytic activity0.0000000000011810Moderately InformativeDirect
Biological Process (BP)regulation of protein metabolic process0.000012340.0002302Moderately InformativeDirect
Biological Process (BP)multi-organism process0.00000012060.00003287Moderately InformativeDirect
Biological Process (BP)regulation of biological quality0.0000000000073710.0000000003929Moderately InformativeDirect
Biological Process (BP)positive regulation of response to stimulus0.020380.0001456Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.000025440.02656Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.56850.5152Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.95321Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.87370.9602Moderately InformativeInherited
Biological Process (BP)cellular localization0.0087490.07963Moderately InformativeInherited
Biological Process (BP)tissue development0.26640.7969Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.0060620.05324Moderately InformativeInherited
Biological Process (BP)response to organic substance0.58910.7488Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization0.93720.6804Moderately InformativeInherited
Biological Process (BP)cellular component biogenesis11Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.004540.07966Moderately InformativeInherited
Biological Process (BP)organ development0.0000070690.01472Moderately InformativeInherited
Biological Process (BP)regulation of developmental process11Moderately InformativeInherited
Biological Process (BP)regulation of localization0.16450.2576Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.00084360.03149Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.00011040.002661Moderately InformativeInherited
Biological Process (BP)ion transport0.0035910.0117Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process10.0001052Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.95251Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function0.0011430.017Moderately InformativeInherited
Biological Process (BP)regulation of protein phosphorylation0.00000000067630.000001727InformativeDirect
Biological Process (BP)developmental process involved in reproduction0.0000000000030540.00000000000005267InformativeDirect
Biological Process (BP)apoptotic process00InformativeDirect
Biological Process (BP)mitochondrion organization00InformativeDirect
Biological Process (BP)response to organic cyclic compound0.0000027660.00002217InformativeDirect
Biological Process (BP)cellular membrane organization00InformativeDirect
Biological Process (BP)response to nutrient levels0.00047070.000001364InformativeDirect
Biological Process (BP)regulation of intracellular transport0.0000000018210.0000000005011InformativeDirect
Biological Process (BP)regulation of organelle organization0.0000014290.00002747InformativeDirect
Biological Process (BP)tube development0.000010210.0001463InformativeDirect
Biological Process (BP)intracellular signal transduction0.000000030930.000000001117InformativeDirect
Biological Process (BP)growth0.0000026450.0004479InformativeDirect
Biological Process (BP)regulation of ion transport0.000034760.00001418InformativeDirect
Biological Process (BP)regulation of cellular component biogenesis0.0000061380.000172InformativeDirect
Biological Process (BP)single organism reproductive process0.0000000035860.00002818InformativeDirect
Biological Process (BP)leukocyte activation0.000000069050.0000006326InformativeDirect
Biological Process (BP)hematopoietic or lymphoid organ development0.0000039290.00003036InformativeDirect
Biological Process (BP)cellular process involved in reproduction0.000000000053720.000000002723InformativeDirect
Biological Process (BP)positive regulation of cellular component organization0.0000033160.00007783InformativeDirect
Biological Process (BP)protein oligomerization0.000000032690.0000002265InformativeDirect
Biological Process (BP)positive regulation of hydrolase activity0.00000041670.0001223InformativeDirect
Biological Process (BP)regulation of peptidase activity00InformativeDirect
Biological Process (BP)cation homeostasis0.000000000000012530.00000000001881InformativeDirect
Biological Process (BP)transmembrane transport0.0000015980.0000002197InformativeDirect
Biological Process (BP)epithelium development0.0000000027430.00008095InformativeDirect
Biological Process (BP)negative regulation of cell death0.000000021160InformativeDirect
Biological Process (BP)reproductive system development00InformativeDirect
Biological Process (BP)regulation of apoptotic signaling pathway0.00000000036220.00000000005884InformativeDirect
Biological Process (BP)positive regulation of signal transduction0.0025490.02169InformativeInherited
Biological Process (BP)tissue morphogenesis0.000096250.003822InformativeInherited
Biological Process (BP)cardiovascular system development0.037050.05115InformativeInherited
Biological Process (BP)regulation of mitotic cell cycle0.71250.8336InformativeInherited
Biological Process (BP)regulation of cell cycle process0.96681InformativeInherited
Biological Process (BP)protein localization to organelle0.026770.02525InformativeInherited
Biological Process (BP)cellular chemical homeostasis0.00066770.0405InformativeInherited
Biological Process (BP)cellular response to endogenous stimulus0.79540.9963InformativeInherited
Biological Process (BP)response to organonitrogen compound0.0033430.009112InformativeInherited
Biological Process (BP)cellular response to nitrogen compound0.002850.009245InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound0.25670.1889InformativeInherited
Biological Process (BP)response to hormone stimulus0.65090.6549InformativeInherited
Biological Process (BP)response to lipid0.56680.4838InformativeInherited
Biological Process (BP)response to wounding0.54120.8163InformativeInherited
Biological Process (BP)sensory organ development0.000079550.004202InformativeInherited
Biological Process (BP)organ morphogenesis0.0036880.1549InformativeInherited
Biological Process (BP)positive regulation of developmental process0.54120.7372InformativeInherited
Biological Process (BP)positive regulation of transport0.22950.1926InformativeInherited
Biological Process (BP)embryo development ending in birth or egg hatching0.075750.04274InformativeInherited
Biological Process (BP)negative regulation of protein metabolic process0.0047240.0002215InformativeInherited
Biological Process (BP)cellular component morphogenesis0.0030370.1511InformativeInherited
Biological Process (BP)regulation of cellular catabolic process0.32340.0005032InformativeInherited
Biological Process (BP)response to light stimulus11InformativeInherited
Biological Process (BP)response to DNA damage stimulus0.037690.06224InformativeInherited
Biological Process (BP)multicellular organismal reproductive process0.058420.5234InformativeInherited
Biological Process (BP)sexual reproduction0.1070.5676InformativeInherited
Biological Process (BP)anatomical structure formation involved in morphogenesis0.020180.188InformativeInherited
Biological Process (BP)cell cycle process0.50820.9393InformativeInherited
Biological Process (BP)angiogenesis0.000058150.0000287Highly InformativeDirect
Biological Process (BP)leukocyte homeostasis00Highly InformativeDirect
Biological Process (BP)mitochondrial transport00Highly InformativeDirect
Biological Process (BP)cellular calcium ion homeostasis00Highly InformativeDirect
Biological Process (BP)mitochondrial membrane organization0.0000000071420.00000000001142Highly InformativeDirect
Biological Process (BP)spermatogenesis0.0000000000000032610.0000000001532Highly InformativeDirect
Biological Process (BP)gonad development00Highly InformativeDirect
Biological Process (BP)response to UV0.0000000000012850.0000000001663Highly InformativeDirect
Biological Process (BP)fertilization0.000015640.000001151Highly InformativeDirect
Biological Process (BP)response to virus0.000084860.0002046Highly InformativeDirect
Biological Process (BP)response to toxic substance00Highly InformativeDirect
Biological Process (BP)response to ionizing radiation0.00000000000056470.00000000000009263Highly InformativeDirect
Biological Process (BP)regulation of autophagy0.000024580.0000003563Highly InformativeDirect
Biological Process (BP)positive regulation of organelle organization0.00000000080170.000000002384Highly InformativeDirect
Biological Process (BP)regulation of mitochondrion organization00Highly InformativeDirect
Biological Process (BP)positive regulation of endopeptidase activity0.000000000056730.00004597Highly InformativeDirect
Biological Process (BP)cellular process involved in reproduction in multicellular organism0.0000450.00001437Highly InformativeDirect
Biological Process (BP)ovulation cycle process00Highly InformativeDirect
Biological Process (BP)negative regulation of protein modification process0.00066920.0004944Highly InformativeDirect
Biological Process (BP)positive regulation of homeostatic process0.0000025420.0000005914Highly InformativeDirect
Biological Process (BP)cell part morphogenesis0.00000000000000950.0000001317Highly InformativeDirect
Biological Process (BP)response to endoplasmic reticulum stress00.00000000000006071Highly InformativeDirect
Biological Process (BP)limb morphogenesis0.000000000000045040.000000003277Highly InformativeDirect
Biological Process (BP)B cell activation0.000081010.00003014Highly InformativeDirect
Biological Process (BP)negative regulation of phosphorylation0.00044520.0002771Highly InformativeDirect
Biological Process (BP)regulation of membrane potential00.00000000000002119Highly InformativeDirect
Biological Process (BP)positive regulation of programmed cell death0.00000018740.0001705Highly InformativeDirect
Biological Process (BP)response to amino acid stimulus0.000000097590.00000008821Highly InformativeDirect
Biological Process (BP)regulation of protein complex assembly0.00000073390.00000003066Highly InformativeDirect
Biological Process (BP)positive regulation of ion transport0.00020140.00007195Highly InformativeDirect
Biological Process (BP)response to alkaloid0.000000001520.000000008256Highly InformativeDirect
Biological Process (BP)regulation of cysteine-type endopeptidase activity involved in apoptotic process0.00000000052830.00000000004482Highly InformativeDirect
Biological Process (BP)regulation of neuron apoptotic process0.00060820.0001649Highly InformativeDirect
Biological Process (BP)multi-organism cellular process0.00000033240.00000811Highly InformativeDirect
Biological Process (BP)development of primary female sexual characteristics0.00029310.000002141Highly InformativeDirect
Biological Process (BP)organelle fusion0.0000000000000032610Highly InformativeDirect
Biological Process (BP)eye morphogenesis0.000023540.00004886Highly InformativeDirect
Biological Process (BP)response to axon injury0.00000000059610.0000000004892Highly InformativeDirect
Biological Process (BP)branching morphogenesis of an epithelial tube00.000000000001012Highly InformativeDirect
Biological Process (BP)regulation of binding0.000000067980.000003451Highly InformativeDirect
Biological Process (BP)protein homooligomerization0.0000000045690.00000000864Highly InformativeDirect
Biological Process (BP)response to glucocorticoid stimulus0.00000019610.000000252Highly InformativeDirect
Biological Process (BP)interaction with host0.00000000000013320.00000000009746Highly InformativeDirect
Biological Process (BP)modification of morphology or physiology of other organism involved in symbiotic interaction00.000000000001634Highly InformativeDirect
Biological Process (BP)regulation of calcium ion transport00Highly InformativeDirect
Biological Process (BP)protein localization to mitochondrion0.00000007260.00000006178Highly InformativeDirect
Biological Process (BP)cellular response to radiation0.000013230.00004205Highly InformativeDirect
Biological Process (BP)regulation of cellular response to stress0.00000024640.000000001274Highly InformativeDirect
Biological Process (BP)extrinsic apoptotic signaling pathway00Highly InformativeDirect
Biological Process (BP)intrinsic apoptotic signaling pathway00Highly InformativeDirect
Biological Process (BP)cell-type specific apoptotic process0.0000000000090620.000000008828Highly InformativeDirect
Biological Process (BP)regulation of ion homeostasis00Highly InformativeDirect
Biological Process (BP)positive regulation of apoptotic signaling pathway0.0000000000022520.00000000000003126Highly InformativeDirect
Biological Process (BP)regulation of intrinsic apoptotic signaling pathway0.0010390.00002861Highly InformativeInherited
Biological Process (BP)pattern specification process0.0000068250.004817Highly InformativeInherited
Biological Process (BP)establishment of protein localization to organelle0.0012690.002238Highly InformativeInherited
Biological Process (BP)post-embryonic organ development0.000011350.003622Highly InformativeInherited
Biological Process (BP)post-embryonic development0.000027190.002343Highly InformativeInherited
Biological Process (BP)positive regulation of intracellular transport0.0081920.002503Highly InformativeInherited
Biological Process (BP)membrane fusion0.0028770.0002471Highly InformativeInherited
Biological Process (BP)cell division0.011130.05878Highly InformativeInherited
Molecular Function (MF)binding00.000000000004022Least InformativeDirect
Molecular Function (MF)transporter activity0.000001080.00001018Moderately InformativeDirect
Molecular Function (MF)enzyme regulator activity0.028190.008634Moderately InformativeInherited
Molecular Function (MF)lipid binding0.0000019650.0000007994InformativeDirect
Molecular Function (MF)protein dimerization activity00InformativeDirect
Molecular Function (MF)peptidase regulator activity0.00035620.00007697InformativeDirect
Molecular Function (MF)protein domain specific binding00Highly InformativeDirect
Molecular Function (MF)cysteine-type endopeptidase regulator activity involved in apoptotic process0.00000029590.00000003082Highly InformativeDirect
Molecular Function (MF)protein heterodimerization activity00.00000000003178Highly InformativeDirect
Cellular Component (CC)membrane00Least InformativeDirect
Cellular Component (CC)cytoplasmic part0.0000000038910Least InformativeDirect
Cellular Component (CC)intracellular organelle part0.000000000000016080.0000000253Least InformativeDirect
Cellular Component (CC)protein complex0.000005520.003103Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.0095890.009542Least InformativeInherited
Cellular Component (CC)intracellular non-membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)endoplasmic reticulum0.0000000000016150.00000000003415Moderately InformativeDirect
Cellular Component (CC)cytosol0.0000034710.0000012Moderately InformativeDirect
Cellular Component (CC)endomembrane system0.0000000047390.0000003368Moderately InformativeDirect
Cellular Component (CC)organelle membrane00Moderately InformativeDirect
Cellular Component (CC)intrinsic to membrane0.00000058140.00002028Moderately InformativeDirect
Cellular Component (CC)organelle envelope00Moderately InformativeDirect
Cellular Component (CC)mitochondrial part00Moderately InformativeDirect
Cellular Component (CC)cytoskeleton0.2020.2501Moderately InformativeInherited
Cellular Component (CC)endoplasmic reticulum membrane0.0000044490.000003533InformativeDirect
Cellular Component (CC)integral to membrane00.0000000000001566InformativeDirect
Cellular Component (CC)microtubule cytoskeleton0.0011850.03119InformativeInherited
Cellular Component (CC)centrosome0.000021620.0001178Highly InformativeDirect
Cellular Component (CC)organelle outer membrane00Highly InformativeDirect
Cellular Component (CC)pore complex00Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0.00004013 Least Informative Direct
Biological Process (BP) developmental process 0.00004128 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0.0000000000001873 Least Informative Direct
Biological Process (BP) localization 0.000067 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.0000000000959 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.7869 Least Informative Inherited
Biological Process (BP) reproduction 0 Moderately Informative Direct
Biological Process (BP) immune system process 0.000001152 Moderately Informative Direct
Biological Process (BP) organelle organization 0.000000002518 Moderately Informative Direct
Biological Process (BP) signal transduction 0.0000000002598 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.00001305 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0.0001052 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.0000000292 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.0000000002315 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.00001634 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 0.0001456 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.0002302 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.00003287 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.0000000003929 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.02656 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.5152 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.9602 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.07963 Moderately Informative Inherited
Biological Process (BP) tissue development 0.7969 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.05324 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.7488 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.6804 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.07966 Moderately Informative Inherited
Biological Process (BP) organ development 0.01472 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.002661 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.2576 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.03149 Moderately Informative Inherited
Biological Process (BP) ion transport 0.0117 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.017 Moderately Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.000001727 Informative Direct
Biological Process (BP) developmental process involved in reproduction 0.00000000000005267 Informative Direct
Biological Process (BP) apoptotic process 0 Informative Direct
Biological Process (BP) mitochondrion organization 0 Informative Direct
Biological Process (BP) response to organic cyclic compound 0.00002217 Informative Direct
Biological Process (BP) cellular membrane organization 0 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0.0005032 Informative Direct
Biological Process (BP) response to nutrient levels 0.000001364 Informative Direct
Biological Process (BP) regulation of intracellular transport 0.0000000005011 Informative Direct
Biological Process (BP) regulation of organelle organization 0.00002747 Informative Direct
Biological Process (BP) tube development 0.0001463 Informative Direct
Biological Process (BP) intracellular signal transduction 0.000000001117 Informative Direct
Biological Process (BP) growth 0.0004479 Informative Direct
Biological Process (BP) regulation of ion transport 0.00001418 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.000172 Informative Direct
Biological Process (BP) single organism reproductive process 0.00002818 Informative Direct
Biological Process (BP) leukocyte activation 0.0000006326 Informative Direct
Biological Process (BP) hematopoietic or lymphoid organ development 0.00003036 Informative Direct
Biological Process (BP) cellular process involved in reproduction 0.000000002723 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.00007783 Informative Direct
Biological Process (BP) negative regulation of protein metabolic process 0.0002215 Informative Direct
Biological Process (BP) protein oligomerization 0.0000002265 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.0001223 Informative Direct
Biological Process (BP) regulation of peptidase activity 0 Informative Direct
Biological Process (BP) cation homeostasis 0.00000000001881 Informative Direct
Biological Process (BP) transmembrane transport 0.0000002197 Informative Direct
Biological Process (BP) epithelium development 0.00008095 Informative Direct
Biological Process (BP) negative regulation of cell death 0 Informative Direct
Biological Process (BP) reproductive system development 0 Informative Direct
Biological Process (BP) regulation of apoptotic signaling pathway 0.00000000005884 Informative Direct
Biological Process (BP) positive regulation of signal transduction 0.02169 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.7739 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.6145 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.9071 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.003822 Informative Inherited
Biological Process (BP) cardiovascular system development 0.05115 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.8336 Informative Inherited
Biological Process (BP) regulation of cell cycle process 1 Informative Inherited
Biological Process (BP) protein localization to organelle 0.02525 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.0405 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.9963 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.009112 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.009245 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.1889 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.6549 Informative Inherited
Biological Process (BP) response to lipid 0.4838 Informative Inherited
Biological Process (BP) response to wounding 0.8163 Informative Inherited
Biological Process (BP) sensory organ development 0.004202 Informative Inherited
Biological Process (BP) organ morphogenesis 0.1549 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.7372 Informative Inherited
Biological Process (BP) positive regulation of transport 0.1926 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.04274 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.1511 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.4178 Informative Inherited
Biological Process (BP) response to light stimulus 1 Informative Inherited
Biological Process (BP) response to DNA damage stimulus 0.06224 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.5234 Informative Inherited
Biological Process (BP) sexual reproduction 0.5676 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.188 Informative Inherited
Biological Process (BP) cell cycle process 0.9393 Informative Inherited
Biological Process (BP) angiogenesis 0.0000287 Highly Informative Direct
Biological Process (BP) leukocyte homeostasis 0 Highly Informative Direct
Biological Process (BP) mitochondrial transport 0 Highly Informative Direct
Biological Process (BP) cellular calcium ion homeostasis 0 Highly Informative Direct
Biological Process (BP) mitochondrial membrane organization 0.00000000001142 Highly Informative Direct
Biological Process (BP) spermatogenesis 0.0000000001532 Highly Informative Direct
Biological Process (BP) gonad development 0 Highly Informative Direct
Biological Process (BP) response to UV 0.0000000001663 Highly Informative Direct
Biological Process (BP) fertilization 0.000001151 Highly Informative Direct
Biological Process (BP) response to virus 0.0002046 Highly Informative Direct
Biological Process (BP) response to toxic substance 0 Highly Informative Direct
Biological Process (BP) positive regulation of catabolic process 0.00002191 Highly Informative Direct
Biological Process (BP) response to ionizing radiation 0.00000000000009263 Highly Informative Direct
Biological Process (BP) regulation of autophagy 0.0000003563 Highly Informative Direct
Biological Process (BP) positive regulation of organelle organization 0.000000002384 Highly Informative Direct
Biological Process (BP) regulation of mitochondrion organization 0 Highly Informative Direct
Biological Process (BP) positive regulation of endopeptidase activity 0.00004597 Highly Informative Direct
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.00001437 Highly Informative Direct
Biological Process (BP) ovulation cycle process 0 Highly Informative Direct
Biological Process (BP) negative regulation of protein modification process 0.0004944 Highly Informative Direct
Biological Process (BP) positive regulation of homeostatic process 0.0000005914 Highly Informative Direct
Biological Process (BP) cell part morphogenesis 0.0000001317 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0.00000000000006071 Highly Informative Direct
Biological Process (BP) limb morphogenesis 0.000000003277 Highly Informative Direct
Biological Process (BP) B cell activation 0.00003014 Highly Informative Direct
Biological Process (BP) negative regulation of phosphorylation 0.0002771 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 0.00000000000002119 Highly Informative Direct
Biological Process (BP) positive regulation of programmed cell death 0.0001705 Highly Informative Direct
Biological Process (BP) response to amino acid stimulus 0.00000008821 Highly Informative Direct
Biological Process (BP) regulation of protein complex assembly 0.00000003066 Highly Informative Direct
Biological Process (BP) positive regulation of ion transport 0.00007195 Highly Informative Direct
Biological Process (BP) response to alkaloid 0.000000008256 Highly Informative Direct
Biological Process (BP) regulation of cysteine-type endopeptidase activity involved in apoptotic process 0.00000000004482 Highly Informative Direct
Biological Process (BP) regulation of neuron apoptotic process 0.0001649 Highly Informative Direct
Biological Process (BP) multi-organism cellular process 0.00000811 Highly Informative Direct
Biological Process (BP) development of primary female sexual characteristics 0.000002141 Highly Informative Direct
Biological Process (BP) organelle fusion 0 Highly Informative Direct
Biological Process (BP) eye morphogenesis 0.00004886 Highly Informative Direct
Biological Process (BP) response to axon injury 0.0000000004892 Highly Informative Direct
Biological Process (BP) branching morphogenesis of an epithelial tube 0.000000000001012 Highly Informative Direct
Biological Process (BP) regulation of binding 0.000003451 Highly Informative Direct
Biological Process (BP) protein homooligomerization 0.00000000864 Highly Informative Direct
Biological Process (BP) response to glucocorticoid stimulus 0.000000252 Highly Informative Direct
Biological Process (BP) interaction with host 0.00000000009746 Highly Informative Direct
Biological Process (BP) modification of morphology or physiology of other organism involved in symbiotic interaction 0.000000000001634 Highly Informative Direct
Biological Process (BP) regulation of calcium ion transport 0 Highly Informative Direct
Biological Process (BP) membrane fusion 0.0002471 Highly Informative Direct
Biological Process (BP) protein localization to mitochondrion 0.00000006178 Highly Informative Direct
Biological Process (BP) cellular response to radiation 0.00004205 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.000000001274 Highly Informative Direct
Biological Process (BP) extrinsic apoptotic signaling pathway 0 Highly Informative Direct
Biological Process (BP) intrinsic apoptotic signaling pathway 0 Highly Informative Direct
Biological Process (BP) cell-type specific apoptotic process 0.000000008828 Highly Informative Direct
Biological Process (BP) regulation of ion homeostasis 0 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic signaling pathway 0.000106 Highly Informative Direct
Biological Process (BP) positive regulation of apoptotic signaling pathway 0.00000000000003126 Highly Informative Direct
Biological Process (BP) regulation of intrinsic apoptotic signaling pathway 0.00002861 Highly Informative Direct
Biological Process (BP) pattern specification process 0.004817 Highly Informative Inherited
Biological Process (BP) establishment of protein localization to organelle 0.002238 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.003622 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.002343 Highly Informative Inherited
Biological Process (BP) positive regulation of response to external stimulus 0.04103 Highly Informative Inherited
Biological Process (BP) regulation of response to nutrient levels 1 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.002503 Highly Informative Inherited
Biological Process (BP) cell division 0.05878 Highly Informative Inherited
Molecular Function (MF) binding 0.000000000004022 Least Informative Direct
Molecular Function (MF) transporter activity 0.00001018 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0.008634 Moderately Informative Inherited
Molecular Function (MF) lipid binding 0.0000007994 Informative Direct
Molecular Function (MF) protein dimerization activity 0 Informative Direct
Molecular Function (MF) peptidase regulator activity 0.00007697 Informative Direct
Molecular Function (MF) protein domain specific binding 0 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 0.00000003082 Highly Informative Direct
Molecular Function (MF) protein heterodimerization activity 0.00000000003178 Highly Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.0000000253 Least Informative Direct
Cellular Component (CC) protein complex 0.003103 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.009542 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.00000000003415 Moderately Informative Direct
Cellular Component (CC) cytosol 0.0000012 Moderately Informative Direct
Cellular Component (CC) endomembrane system 0.0000003368 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 0.00002028 Moderately Informative Direct
Cellular Component (CC) organelle envelope 0 Moderately Informative Direct
Cellular Component (CC) mitochondrial part 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.2501 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 0.000003533 Informative Direct
Cellular Component (CC) integral to membrane 0.0000000000001566 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.03119 Informative Inherited
Cellular Component (CC) centrosome 0.0001178 Highly Informative Direct
Cellular Component (CC) organelle outer membrane 0 Highly Informative Direct
Cellular Component (CC) pore complex 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.002131Least InformativeInherited
Disease Ontology (DO)hematologic cancer0.004355Moderately InformativeInherited
Disease Ontology (DO)connective tissue cancer0.00086InformativeDirect
Disease Ontology (DO)lymphoblastic leukemia0.08569InformativeInherited
Disease Ontology (DO)viral infectious disease0.1318InformativeInherited

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.005423Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.008853Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.1364Least InformativeInherited
Mammalian Phenotype (MP)abnormal leukopoiesis0.005426Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.009641Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.03611Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.04209Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.1709Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal metencephalon morphology0.0001935InformativeDirect
Mammalian Phenotype (MP)abnormal mature B cell morphology0.0007164InformativeDirect
Mammalian Phenotype (MP)decreased germ cell number0.001668InformativeInherited
Mammalian Phenotype (MP)decreased leukocyte cell number0.008739InformativeInherited
Mammalian Phenotype (MP)abnormal lymphocyte cell number0.009172InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.066InformativeInherited
Mammalian Phenotype (MP)abnormal gametes0.5051InformativeInherited
Mammalian Phenotype (MP)abnormal immature B cell morphology0.00003853Highly InformativeDirect
Mammalian Phenotype (MP)decreased mature B cell number0.0002624Highly InformativeDirect
Mammalian Phenotype (MP)abnormal autonomic nervous system morphology0.0005668Highly InformativeDirect
Mammalian Phenotype (MP)abnormal immune organ physiology0.01328Highly InformativeInherited

Document: MP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0Moderately InformativeDirect
Biological processHost-virus interaction0.0000000003481Moderately InformativeDirect
Biological processDifferentiation0.000174Moderately InformativeDirect
Biological processModulation of host cell apoptosis by virus0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus0.0000001301Least InformativeDirect
Cellular componentCytoplasm0.9415Least InformativeInherited
Cellular componentMitochondrion0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.0000082Moderately InformativeDirect
Cellular componentCell junction0.00001648Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.00002589Moderately InformativeDirect
Cellular componentCytoskeleton0.0006389Moderately InformativeDirect
Cellular componentMitochondrion outer membrane0.00000004737InformativeDirect
Cellular componentSynapse0.0000002578InformativeDirect
DomainTransmembrane0Least InformativeDirect
Post-translational modificationDevelopmental protein0.0005953Moderately InformativeDirect
Post-translational modificationPhosphoprotein0.00001458Least InformativeDirect
Post-translational modificationUbl conjugation0.0000000001272Moderately InformativeDirect

Document: KW annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 13 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Bcl-2 inhibitors of programmed cell death domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 13 hidden Markov models representing the Bcl-2 inhibitors of programmed cell death superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]