SUPERFAMILY 1.75 HMM library and genome assignments server


Bcl-2 inhibitors of programmed cell death superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Toxins' membrane translocation domains [ 56836] (5)
Superfamily:   Bcl-2 inhibitors of programmed cell death [ 56854]
Families:   Bcl-2 inhibitors of programmed cell death [ 56855] (10)


Superfamily statistics
Genomes (126) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 1,120 1,326 29
Proteins 1,113 1,321 29


Functional annotation
General category Processes_IC
Detailed category Cell cycle, Apoptosis

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process1.876e-122.154e-05Least InformativeDirect
Biological Process (BP)developmental process1.472e-112.406e-05Least InformativeDirect
Biological Process (BP)single-organism cellular process00Least InformativeDirect
Biological Process (BP)regulation of cellular process00Least InformativeDirect
Biological Process (BP)response to stimulus04.918e-14Least InformativeDirect
Biological Process (BP)localization1.366e-084.384e-05Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis02.828e-11Least InformativeDirect
Biological Process (BP)regulation of metabolic process0.16730.8066Least InformativeInherited
Biological Process (BP)reproduction00Moderately InformativeDirect
Biological Process (BP)immune system process8.037e-115.572e-07Moderately InformativeDirect
Biological Process (BP)organelle organization01.473e-09Moderately InformativeDirect
Biological Process (BP)signal transduction1.29e-106.462e-10Moderately InformativeDirect
Biological Process (BP)response to abiotic stimulus4.687e-061.178e-05Moderately InformativeDirect
Biological Process (BP)cell differentiation7.659e-153.071e-09Moderately InformativeDirect
Biological Process (BP)cellular response to stress3.814e-091.925e-10Moderately InformativeDirect
Biological Process (BP)regulation of programmed cell death00Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process2.881e-069.583e-06Moderately InformativeDirect
Biological Process (BP)regulation of catalytic activity3.316e-120Moderately InformativeDirect
Biological Process (BP)regulation of protein metabolic process9.609e-060.0001037Moderately InformativeDirect
Biological Process (BP)multi-organism process4.919e-081.631e-05Moderately InformativeDirect
Biological Process (BP)positive regulation of response to stimulus0.023090.000145Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction3.436e-050.02819Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.56280.5194Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.95731Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.8580.9554Moderately InformativeInherited
Biological Process (BP)cellular localization0.0062430.06781Moderately InformativeInherited
Biological Process (BP)tissue development0.23730.7748Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.0056340.04497Moderately InformativeInherited
Biological Process (BP)response to organic substance0.5690.73Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization0.94870.6694Moderately InformativeInherited
Biological Process (BP)cellular component biogenesis11Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.0037060.07494Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.0001850.1251Moderately InformativeInherited
Biological Process (BP)organ development4.042e-060.01207Moderately InformativeInherited
Biological Process (BP)regulation of developmental process11Moderately InformativeInherited
Biological Process (BP)regulation of localization0.13230.2138Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.0011580.02654Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function0.00017370.001903Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process7.381e-050.001533Moderately InformativeInherited
Biological Process (BP)ion transport0.0039290.01145Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process15.246e-05Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.94771Moderately InformativeInherited
Biological Process (BP)homeostatic process0.67520.3755Moderately InformativeInherited
Biological Process (BP)cell activation4.742e-083.913e-06InformativeDirect
Biological Process (BP)regulation of protein phosphorylation2.38e-107.33e-07InformativeDirect
Biological Process (BP)mitochondrion organization00InformativeDirect
Biological Process (BP)cell death00InformativeDirect
Biological Process (BP)response to organic cyclic compound3.671e-062.204e-05InformativeDirect
Biological Process (BP)response to nutrient levels0.00026945.099e-07InformativeDirect
Biological Process (BP)regulation of intracellular transport3.576e-098.55e-10InformativeDirect
Biological Process (BP)regulation of organelle organization2.781e-061.89e-05InformativeDirect
Biological Process (BP)intracellular signal transduction5.231e-082.319e-09InformativeDirect
Biological Process (BP)growth8.461e-080.0001081InformativeDirect
Biological Process (BP)regulation of ion transport4.197e-051.142e-05InformativeDirect
Biological Process (BP)regulation of cellular component biogenesis9.055e-060.0001048InformativeDirect
Biological Process (BP)single organism reproductive process1.857e-091.883e-05InformativeDirect
Biological Process (BP)hematopoietic or lymphoid organ development1.282e-061.326e-05InformativeDirect
Biological Process (BP)reproductive structure development02.113e-14InformativeDirect
Biological Process (BP)cellular process involved in reproduction4.403e-112.433e-09InformativeDirect
Biological Process (BP)positive regulation of cellular component organization3.43e-067.296e-05InformativeDirect
Biological Process (BP)positive regulation of hydrolase activity2.008e-092.264e-07InformativeDirect
Biological Process (BP)regulation of cell cycle2.823e-076.907e-06InformativeDirect
Biological Process (BP)regulation of peptidase activity00InformativeDirect
Biological Process (BP)cation homeostasis1.604e-153.509e-12InformativeDirect
Biological Process (BP)transmembrane transport1.165e-061.499e-07InformativeDirect
Biological Process (BP)epithelium development8.019e-103.703e-05InformativeDirect
Biological Process (BP)negative regulation of cell death1.763e-080InformativeDirect
Biological Process (BP)membrane organization00InformativeDirect
Biological Process (BP)regulation of apoptotic signaling pathway3.198e-107.015e-11InformativeDirect
Biological Process (BP)positive regulation of signal transduction0.0025920.02172InformativeInherited
Biological Process (BP)tissue morphogenesis5.846e-050.003359InformativeInherited
Biological Process (BP)cardiovascular system development0.039210.05738InformativeInherited
Biological Process (BP)protein localization to organelle0.028510.02852InformativeInherited
Biological Process (BP)cellular chemical homeostasis0.0012320.05348InformativeInherited
Biological Process (BP)cellular response to endogenous stimulus0.82581InformativeInherited
Biological Process (BP)response to organonitrogen compound0.0041660.009329InformativeInherited
Biological Process (BP)cellular response to nitrogen compound0.0027820.008854InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound0.23530.1868InformativeInherited
Biological Process (BP)response to hormone stimulus0.63890.6454InformativeInherited
Biological Process (BP)response to lipid0.54210.478InformativeInherited
Biological Process (BP)protein complex assembly0.30050.1035InformativeInherited
Biological Process (BP)response to wounding0.57440.8328InformativeInherited
Biological Process (BP)sensory organ development6.362e-050.004101InformativeInherited
Biological Process (BP)organ morphogenesis0.0026240.1425InformativeInherited
Biological Process (BP)positive regulation of developmental process0.59750.7592InformativeInherited
Biological Process (BP)positive regulation of transport0.17250.1685InformativeInherited
Biological Process (BP)embryo development ending in birth or egg hatching0.054470.03384InformativeInherited
Biological Process (BP)negative regulation of protein metabolic process0.0048150.0002156InformativeInherited
Biological Process (BP)cellular component morphogenesis0.0028230.1504InformativeInherited
Biological Process (BP)response to light stimulus11InformativeInherited
Biological Process (BP)response to DNA damage stimulus0.051260.07492InformativeInherited
Biological Process (BP)multicellular organismal reproductive process0.059630.5025InformativeInherited
Biological Process (BP)sexual reproduction0.099260.5402InformativeInherited
Biological Process (BP)anatomical structure formation involved in morphogenesis0.018390.1812InformativeInherited
Biological Process (BP)cell cycle process0.52090.961InformativeInherited
Biological Process (BP)response to acid2.487e-093.061e-10Highly InformativeDirect
Biological Process (BP)angiogenesis6.891e-053.326e-05Highly InformativeDirect
Biological Process (BP)leukocyte homeostasis00Highly InformativeDirect
Biological Process (BP)mitochondrial transport00Highly InformativeDirect
Biological Process (BP)cellular calcium ion homeostasis00Highly InformativeDirect
Biological Process (BP)cellular membrane fusion4.126e-057.093e-08Highly InformativeDirect
Biological Process (BP)spermatogenesis04.821e-11Highly InformativeDirect
Biological Process (BP)cell proliferation09.859e-14Highly InformativeDirect
Biological Process (BP)gonad development00Highly InformativeDirect
Biological Process (BP)response to UV7.984e-131.179e-10Highly InformativeDirect
Biological Process (BP)fertilization1.352e-051.119e-06Highly InformativeDirect
Biological Process (BP)response to virus0.00010670.0002497Highly InformativeDirect
Biological Process (BP)response to toxic substance00Highly InformativeDirect
Biological Process (BP)response to ionizing radiation7.155e-137.17e-14Highly InformativeDirect
Biological Process (BP)regulation of autophagy1.75e-051.53e-07Highly InformativeDirect
Biological Process (BP)positive regulation of organelle organization1.88e-092.16e-09Highly InformativeDirect
Biological Process (BP)regulation of mitochondrion organization00Highly InformativeDirect
Biological Process (BP)positive regulation of peptidase activity1.604e-153.443e-12Highly InformativeDirect
Biological Process (BP)cellular process involved in reproduction in multicellular organism2.741e-058.508e-06Highly InformativeDirect
Biological Process (BP)ovulation cycle process00Highly InformativeDirect
Biological Process (BP)negative regulation of protein modification process0.00059020.0003517Highly InformativeDirect
Biological Process (BP)cell part morphogenesis1.604e-154.771e-08Highly InformativeDirect
Biological Process (BP)ion transmembrane transport4.919e-112.171e-08Highly InformativeDirect
Biological Process (BP)response to endoplasmic reticulum stress05.724e-14Highly InformativeDirect
Biological Process (BP)limb morphogenesis2.348e-141.932e-09Highly InformativeDirect
Biological Process (BP)B cell activation8.744e-052.73e-05Highly InformativeDirect
Biological Process (BP)negative regulation of phosphorylation0.000350.0001964Highly InformativeDirect
Biological Process (BP)regulation of membrane potential01.43e-14Highly InformativeDirect
Biological Process (BP)positive regulation of programmed cell death2.678e-070.0001271Highly InformativeDirect
Biological Process (BP)regulation of protein complex assembly9.549e-072.237e-08Highly InformativeDirect
Biological Process (BP)positive regulation of ion transport0.00028347.62e-05Highly InformativeDirect
Biological Process (BP)response to alkaloid1.84e-096.359e-09Highly InformativeDirect
Biological Process (BP)regulation of neuron apoptotic process0.00099230.0002429Highly InformativeDirect
Biological Process (BP)multi-organism cellular process4.08e-077.644e-06Highly InformativeDirect
Biological Process (BP)development of primary female sexual characteristics0.00052035.561e-06Highly InformativeDirect
Biological Process (BP)organelle fusion3.14e-150Highly InformativeDirect
Biological Process (BP)eye morphogenesis1.701e-055.419e-05Highly InformativeDirect
Biological Process (BP)response to axon injury4.543e-103.605e-10Highly InformativeDirect
Biological Process (BP)branching morphogenesis of an epithelial tube05.39e-13Highly InformativeDirect
Biological Process (BP)regulation of binding6.476e-081.682e-06Highly InformativeDirect
Biological Process (BP)protein homooligomerization1.955e-094.103e-09Highly InformativeDirect
Biological Process (BP)interaction with host3.14e-159.625e-12Highly InformativeDirect
Biological Process (BP)modification of morphology or physiology of other organism involved in symbiotic interaction05.635e-13Highly InformativeDirect
Biological Process (BP)regulation of calcium ion transport00Highly InformativeDirect
Biological Process (BP)cellular response to radiation2.064e-054.158e-05Highly InformativeDirect
Biological Process (BP)establishment of protein localization to mitochondrion2.621e-082.782e-08Highly InformativeDirect
Biological Process (BP)regulation of cellular response to stress2.003e-077.272e-10Highly InformativeDirect
Biological Process (BP)extrinsic apoptotic signaling pathway00Highly InformativeDirect
Biological Process (BP)intrinsic apoptotic signaling pathway00Highly InformativeDirect
Biological Process (BP)regulation of ion homeostasis00Highly InformativeDirect
Biological Process (BP)regulation of cysteine-type endopeptidase activity00Highly InformativeDirect
Biological Process (BP)positive regulation of apoptotic signaling pathway9.238e-133.442e-14Highly InformativeDirect
Biological Process (BP)regulation of intrinsic apoptotic signaling pathway0.00070776.205e-06Highly InformativeDirect
Biological Process (BP)pattern specification process6.536e-060.005423Highly InformativeInherited
Biological Process (BP)development of primary male sexual characteristics0.032820.0556Highly InformativeInherited
Biological Process (BP)response to corticosteroid stimulus0.065170.01154Highly InformativeInherited
Biological Process (BP)post-embryonic organ development9.14e-060.002597Highly InformativeInherited
Biological Process (BP)post-embryonic development2.751e-050.001949Highly InformativeInherited
Biological Process (BP)positive regulation of intracellular transport0.0087470.0029Highly InformativeInherited
Biological Process (BP)cell division0.011750.06341Highly InformativeInherited
Molecular Function (MF)binding01.266e-12Least InformativeDirect
Molecular Function (MF)transporter activity5.049e-072.033e-06Moderately InformativeDirect
Molecular Function (MF)enzyme regulator activity0.021470.00439Moderately InformativeInherited
Molecular Function (MF)lipid binding1.555e-064.963e-07InformativeDirect
Molecular Function (MF)protein dimerization activity2.58e-150InformativeDirect
Molecular Function (MF)peptidase regulator activity0.00024097.464e-05InformativeDirect
Molecular Function (MF)cysteine-type endopeptidase regulator activity involved in apoptotic process2.692e-073.716e-08Highly InformativeDirect
Molecular Function (MF)protein heterodimerization activity6.726e-162.607e-10Highly InformativeDirect
Cellular Component (CC)membrane00Least InformativeDirect
Cellular Component (CC)cytoplasmic part7.817e-082.969e-15Least InformativeDirect
Cellular Component (CC)intracellular organelle part6.638e-142.229e-08Least InformativeDirect
Cellular Component (CC)protein complex1.776e-060.001384Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.0074310.006732Least InformativeInherited
Cellular Component (CC)intracellular non-membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)endoplasmic reticulum1.931e-138.898e-12Moderately InformativeDirect
Cellular Component (CC)cytosol9.011e-086.967e-08Moderately InformativeDirect
Cellular Component (CC)endomembrane system6.191e-104.254e-08Moderately InformativeDirect
Cellular Component (CC)organelle membrane00Moderately InformativeDirect
Cellular Component (CC)intrinsic to membrane5.604e-072.542e-05Moderately InformativeDirect
Cellular Component (CC)organelle envelope00Moderately InformativeDirect
Cellular Component (CC)mitochondrial part00Moderately InformativeDirect
Cellular Component (CC)cytoskeleton0.01060.163Moderately InformativeInherited
Cellular Component (CC)endoplasmic reticulum membrane2.733e-063.006e-06InformativeDirect
Cellular Component (CC)integral to membrane03.698e-14InformativeDirect
Cellular Component (CC)microtubule cytoskeleton0.00052020.01806InformativeInherited
Cellular Component (CC)mitochondrial outer membrane3.702e-079.178e-06Highly InformativeDirect
Cellular Component (CC)centrosome6.931e-075.171e-05Highly InformativeDirect
Cellular Component (CC)pore complex00Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 2.154e-05 Least Informative Direct
Biological Process (BP) developmental process 2.406e-05 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 0 Least Informative Direct
Biological Process (BP) response to stimulus 4.918e-14 Least Informative Direct
Biological Process (BP) localization 4.384e-05 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 2.828e-11 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.8066 Least Informative Inherited
Biological Process (BP) reproduction 0 Moderately Informative Direct
Biological Process (BP) immune system process 5.572e-07 Moderately Informative Direct
Biological Process (BP) organelle organization 1.473e-09 Moderately Informative Direct
Biological Process (BP) signal transduction 6.462e-10 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 1.178e-05 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 5.246e-05 Moderately Informative Direct
Biological Process (BP) cell differentiation 3.071e-09 Moderately Informative Direct
Biological Process (BP) cellular response to stress 1.925e-10 Moderately Informative Direct
Biological Process (BP) regulation of programmed cell death 0 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 9.583e-06 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 0.000145 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.0001037 Moderately Informative Direct
Biological Process (BP) multi-organism process 1.631e-05 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.02819 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.5194 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.9554 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.06781 Moderately Informative Inherited
Biological Process (BP) tissue development 0.7748 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.04497 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.73 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.6694 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.07494 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.1251 Moderately Informative Inherited
Biological Process (BP) organ development 0.01207 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.001533 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.2138 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.02654 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.001903 Moderately Informative Inherited
Biological Process (BP) ion transport 0.01145 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.3755 Moderately Informative Inherited
Biological Process (BP) cell activation 3.913e-06 Informative Direct
Biological Process (BP) regulation of protein phosphorylation 7.33e-07 Informative Direct
Biological Process (BP) mitochondrion organization 0 Informative Direct
Biological Process (BP) cell death 0 Informative Direct
Biological Process (BP) response to organic cyclic compound 2.204e-05 Informative Direct
Biological Process (BP) response to nutrient levels 5.099e-07 Informative Direct
Biological Process (BP) regulation of intracellular transport 8.55e-10 Informative Direct
Biological Process (BP) regulation of organelle organization 1.89e-05 Informative Direct
Biological Process (BP) intracellular signal transduction 2.319e-09 Informative Direct
Biological Process (BP) growth 0.0001081 Informative Direct
Biological Process (BP) regulation of ion transport 1.142e-05 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.0001048 Informative Direct
Biological Process (BP) single organism reproductive process 1.883e-05 Informative Direct
Biological Process (BP) hematopoietic or lymphoid organ development 1.326e-05 Informative Direct
Biological Process (BP) reproductive structure development 2.113e-14 Informative Direct
Biological Process (BP) cellular process involved in reproduction 2.433e-09 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 7.296e-05 Informative Direct
Biological Process (BP) negative regulation of protein metabolic process 0.0002156 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 2.264e-07 Informative Direct
Biological Process (BP) regulation of cell cycle 6.907e-06 Informative Direct
Biological Process (BP) regulation of peptidase activity 0 Informative Direct
Biological Process (BP) cation homeostasis 3.509e-12 Informative Direct
Biological Process (BP) transmembrane transport 1.499e-07 Informative Direct
Biological Process (BP) epithelium development 3.703e-05 Informative Direct
Biological Process (BP) negative regulation of cell death 0 Informative Direct
Biological Process (BP) membrane organization 0 Informative Direct
Biological Process (BP) regulation of apoptotic signaling pathway 7.015e-11 Informative Direct
Biological Process (BP) positive regulation of signal transduction 0.02172 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.7251 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.5658 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.875 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.003359 Informative Inherited
Biological Process (BP) cardiovascular system development 0.05738 Informative Inherited
Biological Process (BP) protein localization to organelle 0.02852 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.05348 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 1 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.009329 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.008854 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.1868 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.6454 Informative Inherited
Biological Process (BP) response to lipid 0.478 Informative Inherited
Biological Process (BP) protein complex assembly 0.1035 Informative Inherited
Biological Process (BP) response to wounding 0.8328 Informative Inherited
Biological Process (BP) sensory organ development 0.004101 Informative Inherited
Biological Process (BP) organ morphogenesis 0.1425 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.7592 Informative Inherited
Biological Process (BP) positive regulation of transport 0.1685 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.03384 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.1504 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.4151 Informative Inherited
Biological Process (BP) response to light stimulus 1 Informative Inherited
Biological Process (BP) response to DNA damage stimulus 0.07492 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.5025 Informative Inherited
Biological Process (BP) sexual reproduction 0.5402 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.1812 Informative Inherited
Biological Process (BP) cell cycle process 0.961 Informative Inherited
Biological Process (BP) response to acid 3.061e-10 Highly Informative Direct
Biological Process (BP) angiogenesis 3.326e-05 Highly Informative Direct
Biological Process (BP) leukocyte homeostasis 0 Highly Informative Direct
Biological Process (BP) mitochondrial transport 0 Highly Informative Direct
Biological Process (BP) cellular calcium ion homeostasis 0 Highly Informative Direct
Biological Process (BP) cellular membrane fusion 7.093e-08 Highly Informative Direct
Biological Process (BP) spermatogenesis 4.821e-11 Highly Informative Direct
Biological Process (BP) cell proliferation 9.859e-14 Highly Informative Direct
Biological Process (BP) gonad development 0 Highly Informative Direct
Biological Process (BP) response to UV 1.179e-10 Highly Informative Direct
Biological Process (BP) fertilization 1.119e-06 Highly Informative Direct
Biological Process (BP) response to virus 0.0002497 Highly Informative Direct
Biological Process (BP) response to toxic substance 0 Highly Informative Direct
Biological Process (BP) response to ionizing radiation 7.17e-14 Highly Informative Direct
Biological Process (BP) regulation of autophagy 1.53e-07 Highly Informative Direct
Biological Process (BP) positive regulation of organelle organization 2.16e-09 Highly Informative Direct
Biological Process (BP) regulation of mitochondrion organization 0 Highly Informative Direct
Biological Process (BP) positive regulation of peptidase activity 3.443e-12 Highly Informative Direct
Biological Process (BP) cellular process involved in reproduction in multicellular organism 8.508e-06 Highly Informative Direct
Biological Process (BP) ovulation cycle process 0 Highly Informative Direct
Biological Process (BP) positive regulation of cellular catabolic process 2.442e-06 Highly Informative Direct
Biological Process (BP) negative regulation of protein modification process 0.0003517 Highly Informative Direct
Biological Process (BP) cell part morphogenesis 4.771e-08 Highly Informative Direct
Biological Process (BP) ion transmembrane transport 2.171e-08 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 5.724e-14 Highly Informative Direct
Biological Process (BP) limb morphogenesis 1.932e-09 Highly Informative Direct
Biological Process (BP) B cell activation 2.73e-05 Highly Informative Direct
Biological Process (BP) negative regulation of phosphorylation 0.0001964 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 1.43e-14 Highly Informative Direct
Biological Process (BP) positive regulation of programmed cell death 0.0001271 Highly Informative Direct
Biological Process (BP) regulation of protein complex assembly 2.237e-08 Highly Informative Direct
Biological Process (BP) positive regulation of ion transport 7.62e-05 Highly Informative Direct
Biological Process (BP) response to alkaloid 6.359e-09 Highly Informative Direct
Biological Process (BP) regulation of neuron apoptotic process 0.0002429 Highly Informative Direct
Biological Process (BP) multi-organism cellular process 7.644e-06 Highly Informative Direct
Biological Process (BP) development of primary female sexual characteristics 5.561e-06 Highly Informative Direct
Biological Process (BP) organelle fusion 0 Highly Informative Direct
Biological Process (BP) eye morphogenesis 5.419e-05 Highly Informative Direct
Biological Process (BP) response to axon injury 3.605e-10 Highly Informative Direct
Biological Process (BP) branching morphogenesis of an epithelial tube 5.39e-13 Highly Informative Direct
Biological Process (BP) regulation of binding 1.682e-06 Highly Informative Direct
Biological Process (BP) protein homooligomerization 4.103e-09 Highly Informative Direct
Biological Process (BP) interaction with host 9.625e-12 Highly Informative Direct
Biological Process (BP) modification of morphology or physiology of other organism involved in symbiotic interaction 5.635e-13 Highly Informative Direct
Biological Process (BP) regulation of calcium ion transport 0 Highly Informative Direct
Biological Process (BP) cellular response to radiation 4.158e-05 Highly Informative Direct
Biological Process (BP) establishment of protein localization to mitochondrion 2.782e-08 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 7.272e-10 Highly Informative Direct
Biological Process (BP) extrinsic apoptotic signaling pathway 0 Highly Informative Direct
Biological Process (BP) intrinsic apoptotic signaling pathway 0 Highly Informative Direct
Biological Process (BP) regulation of ion homeostasis 0 Highly Informative Direct
Biological Process (BP) regulation of cysteine-type endopeptidase activity 0 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic signaling pathway 0.000128 Highly Informative Direct
Biological Process (BP) positive regulation of apoptotic signaling pathway 3.442e-14 Highly Informative Direct
Biological Process (BP) regulation of intrinsic apoptotic signaling pathway 6.205e-06 Highly Informative Direct
Biological Process (BP) pattern specification process 0.005423 Highly Informative Inherited
Biological Process (BP) development of primary male sexual characteristics 0.0556 Highly Informative Inherited
Biological Process (BP) response to corticosteroid stimulus 0.01154 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.002597 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.001949 Highly Informative Inherited
Biological Process (BP) positive regulation of response to external stimulus 0.0348 Highly Informative Inherited
Biological Process (BP) regulation of response to nutrient levels 1 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.0029 Highly Informative Inherited
Biological Process (BP) cell division 0.06341 Highly Informative Inherited
Molecular Function (MF) binding 1.266e-12 Least Informative Direct
Molecular Function (MF) transporter activity 2.033e-06 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0.00439 Moderately Informative Inherited
Molecular Function (MF) lipid binding 4.963e-07 Informative Direct
Molecular Function (MF) protein dimerization activity 0 Informative Direct
Molecular Function (MF) peptidase regulator activity 7.464e-05 Informative Direct
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 3.716e-08 Highly Informative Direct
Molecular Function (MF) protein heterodimerization activity 2.607e-10 Highly Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 2.969e-15 Least Informative Direct
Cellular Component (CC) intracellular organelle part 2.229e-08 Least Informative Direct
Cellular Component (CC) protein complex 0.001384 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.006732 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 8.898e-12 Moderately Informative Direct
Cellular Component (CC) cytosol 6.967e-08 Moderately Informative Direct
Cellular Component (CC) endomembrane system 4.254e-08 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 2.542e-05 Moderately Informative Direct
Cellular Component (CC) organelle envelope 0 Moderately Informative Direct
Cellular Component (CC) mitochondrial part 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.163 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 3.006e-06 Informative Direct
Cellular Component (CC) integral to membrane 3.698e-14 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.01806 Informative Inherited
Cellular Component (CC) mitochondrial outer membrane 9.178e-06 Highly Informative Direct
Cellular Component (CC) centrosome 5.171e-05 Highly Informative Direct
Cellular Component (CC) pore complex 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.001025Least InformativeInherited
Disease Ontology (DO)immune system disease0.08595Least InformativeInherited
Disease Ontology (DO)nervous system disease0.5778Least InformativeInherited
Disease Ontology (DO)hematologic cancer0.001441Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.003162Moderately InformativeInherited
Disease Ontology (DO)cell type cancer0.01157Moderately InformativeInherited
Disease Ontology (DO)endocrine system disease0.0315Moderately InformativeInherited
Disease Ontology (DO)bacterial infectious disease0.09884Moderately InformativeInherited
Disease Ontology (DO)connective tissue cancer0.0001475InformativeDirect
Disease Ontology (DO)thyroid gland disease0.0008986InformativeDirect
Disease Ontology (DO)primary bacterial infectious disease0.002848InformativeInherited
Disease Ontology (DO)chronic leukemia0.01969InformativeInherited
Disease Ontology (DO)lymphoblastic leukemia0.04508InformativeInherited
Disease Ontology (DO)viral infectious disease0.08817InformativeInherited
Disease Ontology (DO)chronic lymphocytic leukemia3.323e-06Highly InformativeDirect
Disease Ontology (DO)Graves' disease0.0001159Highly InformativeDirect
Disease Ontology (DO)tuberculosis0.0008751Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.01392Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.0222Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.197Least InformativeInherited
Mammalian Phenotype (MP)abnormal leukopoiesis0.009098Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.016Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.05441Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.06181Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell morphology0.06392Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal metencephalon morphology0.0003188InformativeDirect
Mammalian Phenotype (MP)abnormal mature B cell morphology0.001122InformativeInherited
Mammalian Phenotype (MP)abnormal lymphocyte cell number0.01556InformativeInherited
Mammalian Phenotype (MP)decreased hematopoietic cell number0.0244InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.06983InformativeInherited
Mammalian Phenotype (MP)abnormal immature B cell morphology0.0001873Highly InformativeDirect
Mammalian Phenotype (MP)abnormal autonomic nervous system morphology0.0006328Highly InformativeDirect
Mammalian Phenotype (MP)abnormal immune organ physiology0.01307Highly InformativeInherited
Mammalian Phenotype (MP)decreased B cell number0.09761Highly InformativeInherited

Document: MP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0Moderately InformativeDirect
Biological processHost-virus interaction3.528e-10Moderately InformativeDirect
Biological processDifferentiation0.0001614Moderately InformativeDirect
Biological processModulation of host cell apoptosis by virus0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus1.196e-07Least InformativeDirect
Cellular componentCytoplasm0.9342Least InformativeInherited
Cellular componentMitochondrion0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle7.414e-06Moderately InformativeDirect
Cellular componentCell junction1.549e-05Moderately InformativeDirect
Cellular componentEndoplasmic reticulum2.222e-05Moderately InformativeDirect
Cellular componentCytoskeleton0.0006234Moderately InformativeDirect
Cellular componentMitochondrion outer membrane4.129e-08InformativeDirect
Cellular componentSynapse2.253e-07InformativeDirect
DomainTransmembrane0Least InformativeDirect
Post-translational modificationDevelopmental protein0.0006052Moderately InformativeDirect
Post-translational modificationPhosphoprotein1.453e-05Least InformativeDirect
Post-translational modificationUbl conjugation9.749e-11Moderately InformativeDirect
Post-translational modificationIsopeptide bond0.0008954Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 13 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Bcl-2 inhibitors of programmed cell death domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 13 hidden Markov models representing the Bcl-2 inhibitors of programmed cell death superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]