SUPERFAMILY 1.75 HMM library and genome assignments server


Bcl-2 inhibitors of programmed cell death superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Toxins' membrane translocation domains [ 56836] (5)
Superfamily:   Bcl-2 inhibitors of programmed cell death [ 56854]
Families:   Bcl-2 inhibitors of programmed cell death [ 56855] (10)


Superfamily statistics
Genomes (140) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,230 1,590 29
Proteins 1,222 1,582 29


Functional annotation
General category Processes_IC
Detailed category Cell cycle, Apoptosis

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process3.848e-124.013e-05Least InformativeDirect
Biological Process (BP)developmental process2.784e-114.128e-05Least InformativeDirect
Biological Process (BP)single-organism cellular process00Least InformativeDirect
Biological Process (BP)regulation of cellular process00Least InformativeDirect
Biological Process (BP)response to stimulus01.873e-13Least InformativeDirect
Biological Process (BP)localization1.949e-086.7e-05Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis09.59e-11Least InformativeDirect
Biological Process (BP)regulation of metabolic process0.13070.7869Least InformativeInherited
Biological Process (BP)reproduction00Moderately InformativeDirect
Biological Process (BP)immune system process2.01e-101.152e-06Moderately InformativeDirect
Biological Process (BP)organelle organization3.261e-152.518e-09Moderately InformativeDirect
Biological Process (BP)signal transduction5.256e-112.598e-10Moderately InformativeDirect
Biological Process (BP)response to abiotic stimulus5.43e-061.305e-05Moderately InformativeDirect
Biological Process (BP)cell differentiation8.783e-142.92e-08Moderately InformativeDirect
Biological Process (BP)cellular response to stress3.546e-092.315e-10Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process2.408e-061.634e-05Moderately InformativeDirect
Biological Process (BP)regulation of catalytic activity1.181e-120Moderately InformativeDirect
Biological Process (BP)regulation of protein metabolic process1.234e-050.0002302Moderately InformativeDirect
Biological Process (BP)multi-organism process1.206e-073.287e-05Moderately InformativeDirect
Biological Process (BP)regulation of biological quality7.371e-123.929e-10Moderately InformativeDirect
Biological Process (BP)positive regulation of response to stimulus0.020380.0001456Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction2.544e-050.02656Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.56850.5152Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.95321Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.87370.9602Moderately InformativeInherited
Biological Process (BP)cellular localization0.0087490.07963Moderately InformativeInherited
Biological Process (BP)tissue development0.26640.7969Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.0060620.05324Moderately InformativeInherited
Biological Process (BP)response to organic substance0.58910.7488Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization0.93720.6804Moderately InformativeInherited
Biological Process (BP)cellular component biogenesis11Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.004540.07966Moderately InformativeInherited
Biological Process (BP)organ development7.069e-060.01472Moderately InformativeInherited
Biological Process (BP)regulation of developmental process11Moderately InformativeInherited
Biological Process (BP)regulation of localization0.16450.2576Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.00084360.03149Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.00011040.002661Moderately InformativeInherited
Biological Process (BP)ion transport0.0035910.0117Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process10.0001052Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.95251Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function0.0011430.017Moderately InformativeInherited
Biological Process (BP)regulation of protein phosphorylation6.763e-101.727e-06InformativeDirect
Biological Process (BP)developmental process involved in reproduction3.054e-125.267e-14InformativeDirect
Biological Process (BP)apoptotic process00InformativeDirect
Biological Process (BP)mitochondrion organization00InformativeDirect
Biological Process (BP)response to organic cyclic compound2.766e-062.217e-05InformativeDirect
Biological Process (BP)cellular membrane organization00InformativeDirect
Biological Process (BP)response to nutrient levels0.00047071.364e-06InformativeDirect
Biological Process (BP)regulation of intracellular transport1.821e-095.011e-10InformativeDirect
Biological Process (BP)regulation of organelle organization1.429e-062.747e-05InformativeDirect
Biological Process (BP)tube development1.021e-050.0001463InformativeDirect
Biological Process (BP)intracellular signal transduction3.093e-081.117e-09InformativeDirect
Biological Process (BP)growth2.645e-060.0004479InformativeDirect
Biological Process (BP)regulation of ion transport3.476e-051.418e-05InformativeDirect
Biological Process (BP)regulation of cellular component biogenesis6.138e-060.000172InformativeDirect
Biological Process (BP)single organism reproductive process3.586e-092.818e-05InformativeDirect
Biological Process (BP)leukocyte activation6.905e-086.326e-07InformativeDirect
Biological Process (BP)hematopoietic or lymphoid organ development3.929e-063.036e-05InformativeDirect
Biological Process (BP)cellular process involved in reproduction5.372e-112.723e-09InformativeDirect
Biological Process (BP)positive regulation of cellular component organization3.316e-067.783e-05InformativeDirect
Biological Process (BP)protein oligomerization3.269e-082.265e-07InformativeDirect
Biological Process (BP)positive regulation of hydrolase activity4.167e-070.0001223InformativeDirect
Biological Process (BP)regulation of peptidase activity00InformativeDirect
Biological Process (BP)cation homeostasis1.253e-141.881e-11InformativeDirect
Biological Process (BP)transmembrane transport1.598e-062.197e-07InformativeDirect
Biological Process (BP)epithelium development2.743e-098.095e-05InformativeDirect
Biological Process (BP)negative regulation of cell death2.116e-080InformativeDirect
Biological Process (BP)reproductive system development00InformativeDirect
Biological Process (BP)regulation of apoptotic signaling pathway3.622e-105.884e-11InformativeDirect
Biological Process (BP)positive regulation of signal transduction0.0025490.02169InformativeInherited
Biological Process (BP)tissue morphogenesis9.625e-050.003822InformativeInherited
Biological Process (BP)cardiovascular system development0.037050.05115InformativeInherited
Biological Process (BP)regulation of mitotic cell cycle0.71250.8336InformativeInherited
Biological Process (BP)regulation of cell cycle process0.96681InformativeInherited
Biological Process (BP)protein localization to organelle0.026770.02525InformativeInherited
Biological Process (BP)cellular chemical homeostasis0.00066770.0405InformativeInherited
Biological Process (BP)cellular response to endogenous stimulus0.79540.9963InformativeInherited
Biological Process (BP)response to organonitrogen compound0.0033430.009112InformativeInherited
Biological Process (BP)cellular response to nitrogen compound0.002850.009245InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound0.25670.1889InformativeInherited
Biological Process (BP)response to hormone stimulus0.65090.6549InformativeInherited
Biological Process (BP)response to lipid0.56680.4838InformativeInherited
Biological Process (BP)response to wounding0.54120.8163InformativeInherited
Biological Process (BP)sensory organ development7.955e-050.004202InformativeInherited
Biological Process (BP)organ morphogenesis0.0036880.1549InformativeInherited
Biological Process (BP)positive regulation of developmental process0.54120.7372InformativeInherited
Biological Process (BP)positive regulation of transport0.22950.1926InformativeInherited
Biological Process (BP)embryo development ending in birth or egg hatching0.075750.04274InformativeInherited
Biological Process (BP)negative regulation of protein metabolic process0.0047240.0002215InformativeInherited
Biological Process (BP)cellular component morphogenesis0.0030370.1511InformativeInherited
Biological Process (BP)regulation of cellular catabolic process0.32340.0005032InformativeInherited
Biological Process (BP)response to light stimulus11InformativeInherited
Biological Process (BP)response to DNA damage stimulus0.037690.06224InformativeInherited
Biological Process (BP)multicellular organismal reproductive process0.058420.5234InformativeInherited
Biological Process (BP)sexual reproduction0.1070.5676InformativeInherited
Biological Process (BP)anatomical structure formation involved in morphogenesis0.020180.188InformativeInherited
Biological Process (BP)cell cycle process0.50820.9393InformativeInherited
Biological Process (BP)angiogenesis5.815e-052.87e-05Highly InformativeDirect
Biological Process (BP)leukocyte homeostasis00Highly InformativeDirect
Biological Process (BP)mitochondrial transport00Highly InformativeDirect
Biological Process (BP)cellular calcium ion homeostasis00Highly InformativeDirect
Biological Process (BP)mitochondrial membrane organization7.142e-091.142e-11Highly InformativeDirect
Biological Process (BP)spermatogenesis3.261e-151.532e-10Highly InformativeDirect
Biological Process (BP)gonad development00Highly InformativeDirect
Biological Process (BP)response to UV1.285e-121.663e-10Highly InformativeDirect
Biological Process (BP)fertilization1.564e-051.151e-06Highly InformativeDirect
Biological Process (BP)response to virus8.486e-050.0002046Highly InformativeDirect
Biological Process (BP)response to toxic substance00Highly InformativeDirect
Biological Process (BP)response to ionizing radiation5.647e-139.263e-14Highly InformativeDirect
Biological Process (BP)regulation of autophagy2.458e-053.563e-07Highly InformativeDirect
Biological Process (BP)positive regulation of organelle organization8.017e-102.384e-09Highly InformativeDirect
Biological Process (BP)regulation of mitochondrion organization00Highly InformativeDirect
Biological Process (BP)positive regulation of endopeptidase activity5.673e-114.597e-05Highly InformativeDirect
Biological Process (BP)cellular process involved in reproduction in multicellular organism4.5e-051.437e-05Highly InformativeDirect
Biological Process (BP)ovulation cycle process00Highly InformativeDirect
Biological Process (BP)negative regulation of protein modification process0.00066920.0004944Highly InformativeDirect
Biological Process (BP)positive regulation of homeostatic process2.542e-065.914e-07Highly InformativeDirect
Biological Process (BP)cell part morphogenesis9.5e-151.317e-07Highly InformativeDirect
Biological Process (BP)response to endoplasmic reticulum stress06.071e-14Highly InformativeDirect
Biological Process (BP)limb morphogenesis4.504e-143.277e-09Highly InformativeDirect
Biological Process (BP)B cell activation8.101e-053.014e-05Highly InformativeDirect
Biological Process (BP)negative regulation of phosphorylation0.00044520.0002771Highly InformativeDirect
Biological Process (BP)regulation of membrane potential02.119e-14Highly InformativeDirect
Biological Process (BP)positive regulation of programmed cell death1.874e-070.0001705Highly InformativeDirect
Biological Process (BP)response to amino acid stimulus9.759e-088.821e-08Highly InformativeDirect
Biological Process (BP)regulation of protein complex assembly7.339e-073.066e-08Highly InformativeDirect
Biological Process (BP)positive regulation of ion transport0.00020147.195e-05Highly InformativeDirect
Biological Process (BP)response to alkaloid1.52e-098.256e-09Highly InformativeDirect
Biological Process (BP)regulation of cysteine-type endopeptidase activity involved in apoptotic process5.283e-104.482e-11Highly InformativeDirect
Biological Process (BP)regulation of neuron apoptotic process0.00060820.0001649Highly InformativeDirect
Biological Process (BP)multi-organism cellular process3.324e-078.11e-06Highly InformativeDirect
Biological Process (BP)development of primary female sexual characteristics0.00029312.141e-06Highly InformativeDirect
Biological Process (BP)organelle fusion3.261e-150Highly InformativeDirect
Biological Process (BP)eye morphogenesis2.354e-054.886e-05Highly InformativeDirect
Biological Process (BP)response to axon injury5.961e-104.892e-10Highly InformativeDirect
Biological Process (BP)branching morphogenesis of an epithelial tube01.012e-12Highly InformativeDirect
Biological Process (BP)regulation of binding6.798e-083.451e-06Highly InformativeDirect
Biological Process (BP)protein homooligomerization4.569e-098.64e-09Highly InformativeDirect
Biological Process (BP)response to glucocorticoid stimulus1.961e-072.52e-07Highly InformativeDirect
Biological Process (BP)interaction with host1.332e-139.746e-11Highly InformativeDirect
Biological Process (BP)modification of morphology or physiology of other organism involved in symbiotic interaction01.634e-12Highly InformativeDirect
Biological Process (BP)regulation of calcium ion transport00Highly InformativeDirect
Biological Process (BP)protein localization to mitochondrion7.26e-086.178e-08Highly InformativeDirect
Biological Process (BP)cellular response to radiation1.323e-054.205e-05Highly InformativeDirect
Biological Process (BP)regulation of cellular response to stress2.464e-071.274e-09Highly InformativeDirect
Biological Process (BP)extrinsic apoptotic signaling pathway00Highly InformativeDirect
Biological Process (BP)intrinsic apoptotic signaling pathway00Highly InformativeDirect
Biological Process (BP)cell-type specific apoptotic process9.062e-128.828e-09Highly InformativeDirect
Biological Process (BP)regulation of ion homeostasis00Highly InformativeDirect
Biological Process (BP)positive regulation of apoptotic signaling pathway2.252e-123.126e-14Highly InformativeDirect
Biological Process (BP)regulation of intrinsic apoptotic signaling pathway0.0010392.861e-05Highly InformativeInherited
Biological Process (BP)pattern specification process6.825e-060.004817Highly InformativeInherited
Biological Process (BP)establishment of protein localization to organelle0.0012690.002238Highly InformativeInherited
Biological Process (BP)post-embryonic organ development1.135e-050.003622Highly InformativeInherited
Biological Process (BP)post-embryonic development2.719e-050.002343Highly InformativeInherited
Biological Process (BP)positive regulation of intracellular transport0.0081920.002503Highly InformativeInherited
Biological Process (BP)membrane fusion0.0028770.0002471Highly InformativeInherited
Biological Process (BP)cell division0.011130.05878Highly InformativeInherited
Molecular Function (MF)binding04.022e-12Least InformativeDirect
Molecular Function (MF)transporter activity1.08e-061.018e-05Moderately InformativeDirect
Molecular Function (MF)enzyme regulator activity0.028190.008634Moderately InformativeInherited
Molecular Function (MF)lipid binding1.965e-067.994e-07InformativeDirect
Molecular Function (MF)protein dimerization activity00InformativeDirect
Molecular Function (MF)peptidase regulator activity0.00035627.697e-05InformativeDirect
Molecular Function (MF)protein domain specific binding00Highly InformativeDirect
Molecular Function (MF)cysteine-type endopeptidase regulator activity involved in apoptotic process2.959e-073.082e-08Highly InformativeDirect
Molecular Function (MF)protein heterodimerization activity03.178e-11Highly InformativeDirect
Cellular Component (CC)membrane00Least InformativeDirect
Cellular Component (CC)cytoplasmic part3.891e-090Least InformativeDirect
Cellular Component (CC)intracellular organelle part1.608e-142.53e-08Least InformativeDirect
Cellular Component (CC)protein complex5.52e-060.003103Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.0095890.009542Least InformativeInherited
Cellular Component (CC)intracellular non-membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)endoplasmic reticulum1.615e-123.415e-11Moderately InformativeDirect
Cellular Component (CC)cytosol3.471e-061.2e-06Moderately InformativeDirect
Cellular Component (CC)endomembrane system4.739e-093.368e-07Moderately InformativeDirect
Cellular Component (CC)organelle membrane00Moderately InformativeDirect
Cellular Component (CC)intrinsic to membrane5.814e-072.028e-05Moderately InformativeDirect
Cellular Component (CC)organelle envelope00Moderately InformativeDirect
Cellular Component (CC)mitochondrial part00Moderately InformativeDirect
Cellular Component (CC)cytoskeleton0.2020.2501Moderately InformativeInherited
Cellular Component (CC)endoplasmic reticulum membrane4.449e-063.533e-06InformativeDirect
Cellular Component (CC)integral to membrane01.566e-13InformativeDirect
Cellular Component (CC)microtubule cytoskeleton0.0011850.03119InformativeInherited
Cellular Component (CC)centrosome2.162e-050.0001178Highly InformativeDirect
Cellular Component (CC)organelle outer membrane00Highly InformativeDirect
Cellular Component (CC)pore complex00Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 4.013e-05 Least Informative Direct
Biological Process (BP) developmental process 4.128e-05 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 0 Least Informative Direct
Biological Process (BP) response to stimulus 1.873e-13 Least Informative Direct
Biological Process (BP) localization 6.7e-05 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 9.59e-11 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.7869 Least Informative Inherited
Biological Process (BP) reproduction 0 Moderately Informative Direct
Biological Process (BP) immune system process 1.152e-06 Moderately Informative Direct
Biological Process (BP) organelle organization 2.518e-09 Moderately Informative Direct
Biological Process (BP) signal transduction 2.598e-10 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 1.305e-05 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0.0001052 Moderately Informative Direct
Biological Process (BP) cell differentiation 2.92e-08 Moderately Informative Direct
Biological Process (BP) cellular response to stress 2.315e-10 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 1.634e-05 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 0.0001456 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.0002302 Moderately Informative Direct
Biological Process (BP) multi-organism process 3.287e-05 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 3.929e-10 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.02656 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.5152 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.9602 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.07963 Moderately Informative Inherited
Biological Process (BP) tissue development 0.7969 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.05324 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.7488 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.6804 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.07966 Moderately Informative Inherited
Biological Process (BP) organ development 0.01472 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.002661 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.2576 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.03149 Moderately Informative Inherited
Biological Process (BP) ion transport 0.0117 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.017 Moderately Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 1.727e-06 Informative Direct
Biological Process (BP) developmental process involved in reproduction 5.267e-14 Informative Direct
Biological Process (BP) apoptotic process 0 Informative Direct
Biological Process (BP) mitochondrion organization 0 Informative Direct
Biological Process (BP) response to organic cyclic compound 2.217e-05 Informative Direct
Biological Process (BP) cellular membrane organization 0 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0.0005032 Informative Direct
Biological Process (BP) response to nutrient levels 1.364e-06 Informative Direct
Biological Process (BP) regulation of intracellular transport 5.011e-10 Informative Direct
Biological Process (BP) regulation of organelle organization 2.747e-05 Informative Direct
Biological Process (BP) tube development 0.0001463 Informative Direct
Biological Process (BP) intracellular signal transduction 1.117e-09 Informative Direct
Biological Process (BP) growth 0.0004479 Informative Direct
Biological Process (BP) regulation of ion transport 1.418e-05 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.000172 Informative Direct
Biological Process (BP) single organism reproductive process 2.818e-05 Informative Direct
Biological Process (BP) leukocyte activation 6.326e-07 Informative Direct
Biological Process (BP) hematopoietic or lymphoid organ development 3.036e-05 Informative Direct
Biological Process (BP) cellular process involved in reproduction 2.723e-09 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 7.783e-05 Informative Direct
Biological Process (BP) negative regulation of protein metabolic process 0.0002215 Informative Direct
Biological Process (BP) protein oligomerization 2.265e-07 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.0001223 Informative Direct
Biological Process (BP) regulation of peptidase activity 0 Informative Direct
Biological Process (BP) cation homeostasis 1.881e-11 Informative Direct
Biological Process (BP) transmembrane transport 2.197e-07 Informative Direct
Biological Process (BP) epithelium development 8.095e-05 Informative Direct
Biological Process (BP) negative regulation of cell death 0 Informative Direct
Biological Process (BP) reproductive system development 0 Informative Direct
Biological Process (BP) regulation of apoptotic signaling pathway 5.884e-11 Informative Direct
Biological Process (BP) positive regulation of signal transduction 0.02169 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.7739 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.6145 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.9071 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.003822 Informative Inherited
Biological Process (BP) cardiovascular system development 0.05115 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.8336 Informative Inherited
Biological Process (BP) regulation of cell cycle process 1 Informative Inherited
Biological Process (BP) protein localization to organelle 0.02525 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.0405 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.9963 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.009112 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.009245 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.1889 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.6549 Informative Inherited
Biological Process (BP) response to lipid 0.4838 Informative Inherited
Biological Process (BP) response to wounding 0.8163 Informative Inherited
Biological Process (BP) sensory organ development 0.004202 Informative Inherited
Biological Process (BP) organ morphogenesis 0.1549 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.7372 Informative Inherited
Biological Process (BP) positive regulation of transport 0.1926 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.04274 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.1511 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.4178 Informative Inherited
Biological Process (BP) response to light stimulus 1 Informative Inherited
Biological Process (BP) response to DNA damage stimulus 0.06224 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.5234 Informative Inherited
Biological Process (BP) sexual reproduction 0.5676 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.188 Informative Inherited
Biological Process (BP) cell cycle process 0.9393 Informative Inherited
Biological Process (BP) angiogenesis 2.87e-05 Highly Informative Direct
Biological Process (BP) leukocyte homeostasis 0 Highly Informative Direct
Biological Process (BP) mitochondrial transport 0 Highly Informative Direct
Biological Process (BP) cellular calcium ion homeostasis 0 Highly Informative Direct
Biological Process (BP) mitochondrial membrane organization 1.142e-11 Highly Informative Direct
Biological Process (BP) spermatogenesis 1.532e-10 Highly Informative Direct
Biological Process (BP) gonad development 0 Highly Informative Direct
Biological Process (BP) response to UV 1.663e-10 Highly Informative Direct
Biological Process (BP) fertilization 1.151e-06 Highly Informative Direct
Biological Process (BP) response to virus 0.0002046 Highly Informative Direct
Biological Process (BP) response to toxic substance 0 Highly Informative Direct
Biological Process (BP) positive regulation of catabolic process 2.191e-05 Highly Informative Direct
Biological Process (BP) response to ionizing radiation 9.263e-14 Highly Informative Direct
Biological Process (BP) regulation of autophagy 3.563e-07 Highly Informative Direct
Biological Process (BP) positive regulation of organelle organization 2.384e-09 Highly Informative Direct
Biological Process (BP) regulation of mitochondrion organization 0 Highly Informative Direct
Biological Process (BP) positive regulation of endopeptidase activity 4.597e-05 Highly Informative Direct
Biological Process (BP) cellular process involved in reproduction in multicellular organism 1.437e-05 Highly Informative Direct
Biological Process (BP) ovulation cycle process 0 Highly Informative Direct
Biological Process (BP) negative regulation of protein modification process 0.0004944 Highly Informative Direct
Biological Process (BP) positive regulation of homeostatic process 5.914e-07 Highly Informative Direct
Biological Process (BP) cell part morphogenesis 1.317e-07 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 6.071e-14 Highly Informative Direct
Biological Process (BP) limb morphogenesis 3.277e-09 Highly Informative Direct
Biological Process (BP) B cell activation 3.014e-05 Highly Informative Direct
Biological Process (BP) negative regulation of phosphorylation 0.0002771 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 2.119e-14 Highly Informative Direct
Biological Process (BP) positive regulation of programmed cell death 0.0001705 Highly Informative Direct
Biological Process (BP) response to amino acid stimulus 8.821e-08 Highly Informative Direct
Biological Process (BP) regulation of protein complex assembly 3.066e-08 Highly Informative Direct
Biological Process (BP) positive regulation of ion transport 7.195e-05 Highly Informative Direct
Biological Process (BP) response to alkaloid 8.256e-09 Highly Informative Direct
Biological Process (BP) regulation of cysteine-type endopeptidase activity involved in apoptotic process 4.482e-11 Highly Informative Direct
Biological Process (BP) regulation of neuron apoptotic process 0.0001649 Highly Informative Direct
Biological Process (BP) multi-organism cellular process 8.11e-06 Highly Informative Direct
Biological Process (BP) development of primary female sexual characteristics 2.141e-06 Highly Informative Direct
Biological Process (BP) organelle fusion 0 Highly Informative Direct
Biological Process (BP) eye morphogenesis 4.886e-05 Highly Informative Direct
Biological Process (BP) response to axon injury 4.892e-10 Highly Informative Direct
Biological Process (BP) branching morphogenesis of an epithelial tube 1.012e-12 Highly Informative Direct
Biological Process (BP) regulation of binding 3.451e-06 Highly Informative Direct
Biological Process (BP) protein homooligomerization 8.64e-09 Highly Informative Direct
Biological Process (BP) response to glucocorticoid stimulus 2.52e-07 Highly Informative Direct
Biological Process (BP) interaction with host 9.746e-11 Highly Informative Direct
Biological Process (BP) modification of morphology or physiology of other organism involved in symbiotic interaction 1.634e-12 Highly Informative Direct
Biological Process (BP) regulation of calcium ion transport 0 Highly Informative Direct
Biological Process (BP) membrane fusion 0.0002471 Highly Informative Direct
Biological Process (BP) protein localization to mitochondrion 6.178e-08 Highly Informative Direct
Biological Process (BP) cellular response to radiation 4.205e-05 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 1.274e-09 Highly Informative Direct
Biological Process (BP) extrinsic apoptotic signaling pathway 0 Highly Informative Direct
Biological Process (BP) intrinsic apoptotic signaling pathway 0 Highly Informative Direct
Biological Process (BP) cell-type specific apoptotic process 8.828e-09 Highly Informative Direct
Biological Process (BP) regulation of ion homeostasis 0 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic signaling pathway 0.000106 Highly Informative Direct
Biological Process (BP) positive regulation of apoptotic signaling pathway 3.126e-14 Highly Informative Direct
Biological Process (BP) regulation of intrinsic apoptotic signaling pathway 2.861e-05 Highly Informative Direct
Biological Process (BP) pattern specification process 0.004817 Highly Informative Inherited
Biological Process (BP) establishment of protein localization to organelle 0.002238 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.003622 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.002343 Highly Informative Inherited
Biological Process (BP) positive regulation of response to external stimulus 0.04103 Highly Informative Inherited
Biological Process (BP) regulation of response to nutrient levels 1 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.002503 Highly Informative Inherited
Biological Process (BP) cell division 0.05878 Highly Informative Inherited
Molecular Function (MF) binding 4.022e-12 Least Informative Direct
Molecular Function (MF) transporter activity 1.018e-05 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0.008634 Moderately Informative Inherited
Molecular Function (MF) lipid binding 7.994e-07 Informative Direct
Molecular Function (MF) protein dimerization activity 0 Informative Direct
Molecular Function (MF) peptidase regulator activity 7.697e-05 Informative Direct
Molecular Function (MF) protein domain specific binding 0 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 3.082e-08 Highly Informative Direct
Molecular Function (MF) protein heterodimerization activity 3.178e-11 Highly Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 2.53e-08 Least Informative Direct
Cellular Component (CC) protein complex 0.003103 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.009542 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 3.415e-11 Moderately Informative Direct
Cellular Component (CC) cytosol 1.2e-06 Moderately Informative Direct
Cellular Component (CC) endomembrane system 3.368e-07 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 2.028e-05 Moderately Informative Direct
Cellular Component (CC) organelle envelope 0 Moderately Informative Direct
Cellular Component (CC) mitochondrial part 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.2501 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 3.533e-06 Informative Direct
Cellular Component (CC) integral to membrane 1.566e-13 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.03119 Informative Inherited
Cellular Component (CC) centrosome 0.0001178 Highly Informative Direct
Cellular Component (CC) organelle outer membrane 0 Highly Informative Direct
Cellular Component (CC) pore complex 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.002131Least InformativeInherited
Disease Ontology (DO)hematologic cancer0.004355Moderately InformativeInherited
Disease Ontology (DO)connective tissue cancer0.00086InformativeDirect
Disease Ontology (DO)lymphoblastic leukemia0.08569InformativeInherited
Disease Ontology (DO)viral infectious disease0.1318InformativeInherited

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.005423Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.008853Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.1364Least InformativeInherited
Mammalian Phenotype (MP)abnormal leukopoiesis0.005426Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.009641Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.03611Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.04209Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.1709Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal metencephalon morphology0.0001935InformativeDirect
Mammalian Phenotype (MP)abnormal mature B cell morphology0.0007164InformativeDirect
Mammalian Phenotype (MP)decreased germ cell number0.001668InformativeInherited
Mammalian Phenotype (MP)decreased leukocyte cell number0.008739InformativeInherited
Mammalian Phenotype (MP)abnormal lymphocyte cell number0.009172InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.066InformativeInherited
Mammalian Phenotype (MP)abnormal gametes0.5051InformativeInherited
Mammalian Phenotype (MP)abnormal immature B cell morphology3.853e-05Highly InformativeDirect
Mammalian Phenotype (MP)decreased mature B cell number0.0002624Highly InformativeDirect
Mammalian Phenotype (MP)abnormal autonomic nervous system morphology0.0005668Highly InformativeDirect
Mammalian Phenotype (MP)abnormal immune organ physiology0.01328Highly InformativeInherited

Document: MP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0Moderately InformativeDirect
Biological processHost-virus interaction3.481e-10Moderately InformativeDirect
Biological processDifferentiation0.000174Moderately InformativeDirect
Biological processModulation of host cell apoptosis by virus0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus1.301e-07Least InformativeDirect
Cellular componentCytoplasm0.9415Least InformativeInherited
Cellular componentMitochondrion0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle8.2e-06Moderately InformativeDirect
Cellular componentCell junction1.648e-05Moderately InformativeDirect
Cellular componentEndoplasmic reticulum2.589e-05Moderately InformativeDirect
Cellular componentCytoskeleton0.0006389Moderately InformativeDirect
Cellular componentMitochondrion outer membrane4.737e-08InformativeDirect
Cellular componentSynapse2.578e-07InformativeDirect
DomainTransmembrane0Least InformativeDirect
Post-translational modificationDevelopmental protein0.0005953Moderately InformativeDirect
Post-translational modificationPhosphoprotein1.458e-05Least InformativeDirect
Post-translational modificationUbl conjugation1.272e-10Moderately InformativeDirect

Document: KW annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 13 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Bcl-2 inhibitors of programmed cell death domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 13 hidden Markov models representing the Bcl-2 inhibitors of programmed cell death superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]