SUPERFAMILY 1.75 HMM library and genome assignments server


Bcl-2 inhibitors of programmed cell death superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Toxins' membrane translocation domains [ 56836] (5)
Superfamily:   Bcl-2 inhibitors of programmed cell death [ 56854]
Families:   Bcl-2 inhibitors of programmed cell death [ 56855] (10)


Superfamily statistics
Genomes (126) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 1,120 1,326 29
Proteins 1,113 1,321 29


Functional annotation
General category Processes_IC
Detailed category Cell cycle, Apoptosis

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process2.008e-122.199e-05Least InformativeDirect
Biological Process (BP)developmental process1.553e-112.449e-05Least InformativeDirect
Biological Process (BP)single-organism cellular process00Least InformativeDirect
Biological Process (BP)regulation of cellular process00Least InformativeDirect
Biological Process (BP)response to stimulus05.078e-14Least InformativeDirect
Biological Process (BP)localization1.407e-084.393e-05Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis02.956e-11Least InformativeDirect
Biological Process (BP)regulation of metabolic process0.16420.8054Least InformativeInherited
Biological Process (BP)reproduction00Moderately InformativeDirect
Biological Process (BP)immune system process8.15e-115.666e-07Moderately InformativeDirect
Biological Process (BP)organelle organization01.52e-09Moderately InformativeDirect
Biological Process (BP)signal transduction1.218e-106.837e-10Moderately InformativeDirect
Biological Process (BP)response to abiotic stimulus4.529e-061.159e-05Moderately InformativeDirect
Biological Process (BP)cell differentiation7.694e-153.205e-09Moderately InformativeDirect
Biological Process (BP)cellular response to stress4.259e-091.933e-10Moderately InformativeDirect
Biological Process (BP)regulation of programmed cell death00Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process2.821e-069.769e-06Moderately InformativeDirect
Biological Process (BP)regulation of catalytic activity3.351e-120Moderately InformativeDirect
Biological Process (BP)regulation of protein metabolic process9.889e-060.0001041Moderately InformativeDirect
Biological Process (BP)multi-organism process4.903e-081.657e-05Moderately InformativeDirect
Biological Process (BP)positive regulation of response to stimulus0.02240.0001458Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction3.085e-050.02852Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.56260.5118Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.95961Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.86090.9567Moderately InformativeInherited
Biological Process (BP)cellular localization0.006480.0672Moderately InformativeInherited
Biological Process (BP)tissue development0.25020.7781Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.0057790.04484Moderately InformativeInherited
Biological Process (BP)response to organic substance0.5770.7237Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization0.94940.6733Moderately InformativeInherited
Biological Process (BP)cellular component biogenesis11Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.0040840.07556Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.00019190.1246Moderately InformativeInherited
Biological Process (BP)organ development4.287e-060.01196Moderately InformativeInherited
Biological Process (BP)regulation of developmental process11Moderately InformativeInherited
Biological Process (BP)regulation of localization0.13570.2172Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.0012310.02734Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function0.00016510.00193Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process7.134e-050.001557Moderately InformativeInherited
Biological Process (BP)ion transport0.0038970.01163Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process15.204e-05Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.95061Moderately InformativeInherited
Biological Process (BP)homeostatic process0.67510.371Moderately InformativeInherited
Biological Process (BP)cell activation4.864e-083.818e-06InformativeDirect
Biological Process (BP)regulation of protein phosphorylation2.354e-107.362e-07InformativeDirect
Biological Process (BP)mitochondrion organization00InformativeDirect
Biological Process (BP)cell death00InformativeDirect
Biological Process (BP)response to organic cyclic compound3.37e-062.216e-05InformativeDirect
Biological Process (BP)response to nutrient levels0.00026825.087e-07InformativeDirect
Biological Process (BP)regulation of intracellular transport3.09e-098.186e-10InformativeDirect
Biological Process (BP)regulation of organelle organization2.766e-061.862e-05InformativeDirect
Biological Process (BP)intracellular signal transduction5.083e-082.083e-09InformativeDirect
Biological Process (BP)growth8.384e-080.0001088InformativeDirect
Biological Process (BP)regulation of ion transport5.019e-051.188e-05InformativeDirect
Biological Process (BP)regulation of cellular component biogenesis9.206e-060.0001077InformativeDirect
Biological Process (BP)single organism reproductive process2.196e-091.992e-05InformativeDirect
Biological Process (BP)hematopoietic or lymphoid organ development1.231e-061.302e-05InformativeDirect
Biological Process (BP)reproductive structure development02.285e-14InformativeDirect
Biological Process (BP)cellular process involved in reproduction4.625e-112.594e-09InformativeDirect
Biological Process (BP)positive regulation of cellular component organization4.137e-067.37e-05InformativeDirect
Biological Process (BP)positive regulation of hydrolase activity1.811e-092.344e-07InformativeDirect
Biological Process (BP)regulation of cell cycle2.673e-076.815e-06InformativeDirect
Biological Process (BP)regulation of peptidase activity00InformativeDirect
Biological Process (BP)cation homeostasis1.61e-153.504e-12InformativeDirect
Biological Process (BP)transmembrane transport1.137e-061.432e-07InformativeDirect
Biological Process (BP)epithelium development1.047e-093.862e-05InformativeDirect
Biological Process (BP)negative regulation of cell death1.734e-080InformativeDirect
Biological Process (BP)membrane organization00InformativeDirect
Biological Process (BP)regulation of apoptotic signaling pathway3.209e-107.409e-11InformativeDirect
Biological Process (BP)positive regulation of signal transduction0.0025970.02196InformativeInherited
Biological Process (BP)tissue morphogenesis8.077e-050.003445InformativeInherited
Biological Process (BP)cardiovascular system development0.037920.05671InformativeInherited
Biological Process (BP)protein localization to organelle0.029740.02877InformativeInherited
Biological Process (BP)cellular chemical homeostasis0.0012330.05242InformativeInherited
Biological Process (BP)cellular response to endogenous stimulus0.81851InformativeInherited
Biological Process (BP)response to organonitrogen compound0.0042930.009353InformativeInherited
Biological Process (BP)cellular response to nitrogen compound0.0026810.008832InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound0.23020.1843InformativeInherited
Biological Process (BP)response to hormone stimulus0.63970.6459InformativeInherited
Biological Process (BP)response to lipid0.53390.4764InformativeInherited
Biological Process (BP)protein complex assembly0.30340.1041InformativeInherited
Biological Process (BP)response to wounding0.58450.8333InformativeInherited
Biological Process (BP)sensory organ development6.622e-050.004121InformativeInherited
Biological Process (BP)organ morphogenesis0.0029450.1435InformativeInherited
Biological Process (BP)positive regulation of developmental process0.59360.757InformativeInherited
Biological Process (BP)positive regulation of transport0.18590.1743InformativeInherited
Biological Process (BP)embryo development ending in birth or egg hatching0.054530.03352InformativeInherited
Biological Process (BP)negative regulation of protein metabolic process0.0050510.0002202InformativeInherited
Biological Process (BP)cellular component morphogenesis0.002930.15InformativeInherited
Biological Process (BP)response to light stimulus11InformativeInherited
Biological Process (BP)response to DNA damage stimulus0.048410.07335InformativeInherited
Biological Process (BP)multicellular organismal reproductive process0.063990.5103InformativeInherited
Biological Process (BP)sexual reproduction0.10590.5479InformativeInherited
Biological Process (BP)anatomical structure formation involved in morphogenesis0.018810.1814InformativeInherited
Biological Process (BP)cell cycle process0.51890.9595InformativeInherited
Biological Process (BP)response to acid2.404e-092.959e-10Highly InformativeDirect
Biological Process (BP)angiogenesis6.715e-053.285e-05Highly InformativeDirect
Biological Process (BP)leukocyte homeostasis00Highly InformativeDirect
Biological Process (BP)mitochondrial transport00Highly InformativeDirect
Biological Process (BP)cellular calcium ion homeostasis00Highly InformativeDirect
Biological Process (BP)cellular membrane fusion3.296e-056.361e-08Highly InformativeDirect
Biological Process (BP)spermatogenesis05.809e-11Highly InformativeDirect
Biological Process (BP)cell proliferation01.002e-13Highly InformativeDirect
Biological Process (BP)gonad development00Highly InformativeDirect
Biological Process (BP)response to UV7.925e-131.171e-10Highly InformativeDirect
Biological Process (BP)fertilization1.223e-051.061e-06Highly InformativeDirect
Biological Process (BP)response to virus0.00010580.0002525Highly InformativeDirect
Biological Process (BP)response to toxic substance00Highly InformativeDirect
Biological Process (BP)response to ionizing radiation7.181e-137.006e-14Highly InformativeDirect
Biological Process (BP)regulation of autophagy1.863e-051.548e-07Highly InformativeDirect
Biological Process (BP)positive regulation of organelle organization1.765e-092.098e-09Highly InformativeDirect
Biological Process (BP)regulation of mitochondrion organization00Highly InformativeDirect
Biological Process (BP)positive regulation of peptidase activity1.61e-152.954e-12Highly InformativeDirect
Biological Process (BP)cellular process involved in reproduction in multicellular organism2.845e-058.675e-06Highly InformativeDirect
Biological Process (BP)ovulation cycle process00Highly InformativeDirect
Biological Process (BP)negative regulation of protein modification process0.00056090.0003473Highly InformativeDirect
Biological Process (BP)cell part morphogenesis1.61e-154.767e-08Highly InformativeDirect
Biological Process (BP)ion transmembrane transport4.862e-112.062e-08Highly InformativeDirect
Biological Process (BP)response to endoplasmic reticulum stress05.887e-14Highly InformativeDirect
Biological Process (BP)limb morphogenesis2.358e-141.892e-09Highly InformativeDirect
Biological Process (BP)B cell activation8.763e-052.729e-05Highly InformativeDirect
Biological Process (BP)negative regulation of phosphorylation0.00035030.0001988Highly InformativeDirect
Biological Process (BP)regulation of membrane potential01.431e-14Highly InformativeDirect
Biological Process (BP)positive regulation of programmed cell death2.506e-070.0001215Highly InformativeDirect
Biological Process (BP)regulation of protein complex assembly8.773e-072.175e-08Highly InformativeDirect
Biological Process (BP)positive regulation of ion transport0.0002767.79e-05Highly InformativeDirect
Biological Process (BP)response to alkaloid1.676e-096.243e-09Highly InformativeDirect
Biological Process (BP)regulation of neuron apoptotic process0.0009490.00023Highly InformativeDirect
Biological Process (BP)multi-organism cellular process4.039e-077.615e-06Highly InformativeDirect
Biological Process (BP)development of primary female sexual characteristics0.00038713.947e-06Highly InformativeDirect
Biological Process (BP)organelle fusion1.61e-150Highly InformativeDirect
Biological Process (BP)eye morphogenesis1.843e-055.578e-05Highly InformativeDirect
Biological Process (BP)response to axon injury4.519e-103.587e-10Highly InformativeDirect
Biological Process (BP)regulation of binding6.423e-081.73e-06Highly InformativeDirect
Biological Process (BP)protein homooligomerization2.193e-094.402e-09Highly InformativeDirect
Biological Process (BP)interaction with host3.152e-159.702e-12Highly InformativeDirect
Biological Process (BP)modification of morphology or physiology of other organism involved in symbiotic interaction05.608e-13Highly InformativeDirect
Biological Process (BP)regulation of calcium ion transport00Highly InformativeDirect
Biological Process (BP)epithelial tube morphogenesis1.61e-157.367e-10Highly InformativeDirect
Biological Process (BP)morphogenesis of a branching epithelium01.77e-12Highly InformativeDirect
Biological Process (BP)cellular response to radiation2.068e-054.125e-05Highly InformativeDirect
Biological Process (BP)establishment of protein localization to mitochondrion2.606e-082.768e-08Highly InformativeDirect
Biological Process (BP)regulation of cellular response to stress1.932e-077.003e-10Highly InformativeDirect
Biological Process (BP)extrinsic apoptotic signaling pathway00Highly InformativeDirect
Biological Process (BP)intrinsic apoptotic signaling pathway00Highly InformativeDirect
Biological Process (BP)regulation of ion homeostasis00Highly InformativeDirect
Biological Process (BP)regulation of cysteine-type endopeptidase activity00Highly InformativeDirect
Biological Process (BP)positive regulation of apoptotic signaling pathway9.263e-133.114e-14Highly InformativeDirect
Biological Process (BP)regulation of intrinsic apoptotic signaling pathway0.00070845.692e-06Highly InformativeDirect
Biological Process (BP)pattern specification process6.417e-060.005384Highly InformativeInherited
Biological Process (BP)development of primary male sexual characteristics0.039620.06615Highly InformativeInherited
Biological Process (BP)response to corticosteroid stimulus0.065230.01154Highly InformativeInherited
Biological Process (BP)post-embryonic organ development8.907e-060.00258Highly InformativeInherited
Biological Process (BP)post-embryonic development2.693e-050.001915Highly InformativeInherited
Biological Process (BP)positive regulation of intracellular transport0.0078880.002992Highly InformativeInherited
Biological Process (BP)cell division0.011660.06307Highly InformativeInherited
Molecular Function (MF)binding01.387e-12Least InformativeDirect
Molecular Function (MF)transporter activity4.988e-072.054e-06Moderately InformativeDirect
Molecular Function (MF)enzyme regulator activity0.021310.004392Moderately InformativeInherited
Molecular Function (MF)lipid binding1.463e-065.163e-07InformativeDirect
Molecular Function (MF)protein dimerization activity2.589e-150InformativeDirect
Molecular Function (MF)peptidase regulator activity0.00024427.599e-05InformativeDirect
Molecular Function (MF)cysteine-type endopeptidase regulator activity involved in apoptotic process2.677e-073.694e-08Highly InformativeDirect
Molecular Function (MF)protein heterodimerization activity6.738e-162.772e-10Highly InformativeDirect
Cellular Component (CC)membrane00Least InformativeDirect
Cellular Component (CC)cytoplasmic part7.817e-082.972e-15Least InformativeDirect
Cellular Component (CC)intracellular organelle part6.542e-142.267e-08Least InformativeDirect
Cellular Component (CC)protein complex1.77e-060.001409Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.007580.006774Least InformativeInherited
Cellular Component (CC)intracellular non-membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)endoplasmic reticulum2.171e-139.067e-12Moderately InformativeDirect
Cellular Component (CC)cytosol8.812e-087.2e-08Moderately InformativeDirect
Cellular Component (CC)endomembrane system7.077e-104.341e-08Moderately InformativeDirect
Cellular Component (CC)organelle membrane00Moderately InformativeDirect
Cellular Component (CC)intrinsic to membrane5.292e-072.49e-05Moderately InformativeDirect
Cellular Component (CC)organelle envelope00Moderately InformativeDirect
Cellular Component (CC)mitochondrial part00Moderately InformativeDirect
Cellular Component (CC)cytoskeleton0.010550.1633Moderately InformativeInherited
Cellular Component (CC)endoplasmic reticulum membrane3.546e-063.041e-06InformativeDirect
Cellular Component (CC)integral to membrane03.83e-14InformativeDirect
Cellular Component (CC)microtubule cytoskeleton0.00051890.01813InformativeInherited
Cellular Component (CC)mitochondrial outer membrane3.703e-078.232e-06Highly InformativeDirect
Cellular Component (CC)centrosome6.896e-075.363e-05Highly InformativeDirect
Cellular Component (CC)pore complex00Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 2.199e-05 Least Informative Direct
Biological Process (BP) developmental process 2.449e-05 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 0 Least Informative Direct
Biological Process (BP) response to stimulus 5.078e-14 Least Informative Direct
Biological Process (BP) localization 4.393e-05 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 2.956e-11 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.8054 Least Informative Inherited
Biological Process (BP) reproduction 0 Moderately Informative Direct
Biological Process (BP) immune system process 5.666e-07 Moderately Informative Direct
Biological Process (BP) organelle organization 1.52e-09 Moderately Informative Direct
Biological Process (BP) signal transduction 6.837e-10 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 1.159e-05 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 5.204e-05 Moderately Informative Direct
Biological Process (BP) cell differentiation 3.205e-09 Moderately Informative Direct
Biological Process (BP) cellular response to stress 1.933e-10 Moderately Informative Direct
Biological Process (BP) regulation of programmed cell death 0 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 9.769e-06 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 0.0001458 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.0001041 Moderately Informative Direct
Biological Process (BP) multi-organism process 1.657e-05 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.02852 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.5118 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.9567 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.0672 Moderately Informative Inherited
Biological Process (BP) tissue development 0.7781 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.04484 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.7237 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.6733 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.07556 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.1246 Moderately Informative Inherited
Biological Process (BP) organ development 0.01196 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.001557 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.2172 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.02734 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.00193 Moderately Informative Inherited
Biological Process (BP) ion transport 0.01163 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.371 Moderately Informative Inherited
Biological Process (BP) cell activation 3.818e-06 Informative Direct
Biological Process (BP) regulation of protein phosphorylation 7.362e-07 Informative Direct
Biological Process (BP) mitochondrion organization 0 Informative Direct
Biological Process (BP) cell death 0 Informative Direct
Biological Process (BP) response to organic cyclic compound 2.216e-05 Informative Direct
Biological Process (BP) response to nutrient levels 5.087e-07 Informative Direct
Biological Process (BP) regulation of intracellular transport 8.186e-10 Informative Direct
Biological Process (BP) regulation of organelle organization 1.862e-05 Informative Direct
Biological Process (BP) intracellular signal transduction 2.083e-09 Informative Direct
Biological Process (BP) growth 0.0001088 Informative Direct
Biological Process (BP) regulation of ion transport 1.188e-05 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.0001077 Informative Direct
Biological Process (BP) single organism reproductive process 1.992e-05 Informative Direct
Biological Process (BP) hematopoietic or lymphoid organ development 1.302e-05 Informative Direct
Biological Process (BP) reproductive structure development 2.285e-14 Informative Direct
Biological Process (BP) cellular process involved in reproduction 2.594e-09 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 7.37e-05 Informative Direct
Biological Process (BP) negative regulation of protein metabolic process 0.0002202 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 2.344e-07 Informative Direct
Biological Process (BP) regulation of cell cycle 6.815e-06 Informative Direct
Biological Process (BP) regulation of peptidase activity 0 Informative Direct
Biological Process (BP) cation homeostasis 3.504e-12 Informative Direct
Biological Process (BP) transmembrane transport 1.432e-07 Informative Direct
Biological Process (BP) epithelium development 3.862e-05 Informative Direct
Biological Process (BP) negative regulation of cell death 0 Informative Direct
Biological Process (BP) membrane organization 0 Informative Direct
Biological Process (BP) regulation of apoptotic signaling pathway 7.409e-11 Informative Direct
Biological Process (BP) positive regulation of signal transduction 0.02196 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.7336 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.5731 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.88 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.003445 Informative Inherited
Biological Process (BP) cardiovascular system development 0.05671 Informative Inherited
Biological Process (BP) protein localization to organelle 0.02877 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.05242 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 1 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.009353 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.008832 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.1843 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.6459 Informative Inherited
Biological Process (BP) response to lipid 0.4764 Informative Inherited
Biological Process (BP) protein complex assembly 0.1041 Informative Inherited
Biological Process (BP) response to wounding 0.8333 Informative Inherited
Biological Process (BP) sensory organ development 0.004121 Informative Inherited
Biological Process (BP) organ morphogenesis 0.1435 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.757 Informative Inherited
Biological Process (BP) positive regulation of transport 0.1743 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.03352 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.15 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.4142 Informative Inherited
Biological Process (BP) response to light stimulus 1 Informative Inherited
Biological Process (BP) response to DNA damage stimulus 0.07335 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.5103 Informative Inherited
Biological Process (BP) sexual reproduction 0.5479 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.1814 Informative Inherited
Biological Process (BP) cell cycle process 0.9595 Informative Inherited
Biological Process (BP) response to acid 2.959e-10 Highly Informative Direct
Biological Process (BP) angiogenesis 3.285e-05 Highly Informative Direct
Biological Process (BP) leukocyte homeostasis 0 Highly Informative Direct
Biological Process (BP) mitochondrial transport 0 Highly Informative Direct
Biological Process (BP) cellular calcium ion homeostasis 0 Highly Informative Direct
Biological Process (BP) cellular membrane fusion 6.361e-08 Highly Informative Direct
Biological Process (BP) spermatogenesis 5.809e-11 Highly Informative Direct
Biological Process (BP) cell proliferation 1.002e-13 Highly Informative Direct
Biological Process (BP) gonad development 0 Highly Informative Direct
Biological Process (BP) response to UV 1.171e-10 Highly Informative Direct
Biological Process (BP) fertilization 1.061e-06 Highly Informative Direct
Biological Process (BP) response to virus 0.0002525 Highly Informative Direct
Biological Process (BP) response to toxic substance 0 Highly Informative Direct
Biological Process (BP) response to ionizing radiation 7.006e-14 Highly Informative Direct
Biological Process (BP) regulation of autophagy 1.548e-07 Highly Informative Direct
Biological Process (BP) positive regulation of organelle organization 2.098e-09 Highly Informative Direct
Biological Process (BP) regulation of mitochondrion organization 0 Highly Informative Direct
Biological Process (BP) positive regulation of peptidase activity 2.954e-12 Highly Informative Direct
Biological Process (BP) cellular process involved in reproduction in multicellular organism 8.675e-06 Highly Informative Direct
Biological Process (BP) ovulation cycle process 0 Highly Informative Direct
Biological Process (BP) positive regulation of cellular catabolic process 2.625e-06 Highly Informative Direct
Biological Process (BP) negative regulation of protein modification process 0.0003473 Highly Informative Direct
Biological Process (BP) cell part morphogenesis 4.767e-08 Highly Informative Direct
Biological Process (BP) ion transmembrane transport 2.062e-08 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 5.887e-14 Highly Informative Direct
Biological Process (BP) limb morphogenesis 1.892e-09 Highly Informative Direct
Biological Process (BP) B cell activation 2.729e-05 Highly Informative Direct
Biological Process (BP) negative regulation of phosphorylation 0.0001988 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 1.431e-14 Highly Informative Direct
Biological Process (BP) positive regulation of programmed cell death 0.0001215 Highly Informative Direct
Biological Process (BP) regulation of protein complex assembly 2.175e-08 Highly Informative Direct
Biological Process (BP) positive regulation of ion transport 7.79e-05 Highly Informative Direct
Biological Process (BP) response to alkaloid 6.243e-09 Highly Informative Direct
Biological Process (BP) regulation of neuron apoptotic process 0.00023 Highly Informative Direct
Biological Process (BP) multi-organism cellular process 7.615e-06 Highly Informative Direct
Biological Process (BP) development of primary female sexual characteristics 3.947e-06 Highly Informative Direct
Biological Process (BP) organelle fusion 0 Highly Informative Direct
Biological Process (BP) eye morphogenesis 5.578e-05 Highly Informative Direct
Biological Process (BP) response to axon injury 3.587e-10 Highly Informative Direct
Biological Process (BP) regulation of binding 1.73e-06 Highly Informative Direct
Biological Process (BP) protein homooligomerization 4.402e-09 Highly Informative Direct
Biological Process (BP) interaction with host 9.702e-12 Highly Informative Direct
Biological Process (BP) modification of morphology or physiology of other organism involved in symbiotic interaction 5.608e-13 Highly Informative Direct
Biological Process (BP) regulation of calcium ion transport 0 Highly Informative Direct
Biological Process (BP) epithelial tube morphogenesis 7.367e-10 Highly Informative Direct
Biological Process (BP) morphogenesis of a branching epithelium 1.77e-12 Highly Informative Direct
Biological Process (BP) cellular response to radiation 4.125e-05 Highly Informative Direct
Biological Process (BP) establishment of protein localization to mitochondrion 2.768e-08 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 7.003e-10 Highly Informative Direct
Biological Process (BP) extrinsic apoptotic signaling pathway 0 Highly Informative Direct
Biological Process (BP) intrinsic apoptotic signaling pathway 0 Highly Informative Direct
Biological Process (BP) regulation of ion homeostasis 0 Highly Informative Direct
Biological Process (BP) regulation of cysteine-type endopeptidase activity 0 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic signaling pathway 0.0001342 Highly Informative Direct
Biological Process (BP) positive regulation of apoptotic signaling pathway 3.114e-14 Highly Informative Direct
Biological Process (BP) regulation of intrinsic apoptotic signaling pathway 5.692e-06 Highly Informative Direct
Biological Process (BP) pattern specification process 0.005384 Highly Informative Inherited
Biological Process (BP) development of primary male sexual characteristics 0.06615 Highly Informative Inherited
Biological Process (BP) response to corticosteroid stimulus 0.01154 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.00258 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.001915 Highly Informative Inherited
Biological Process (BP) positive regulation of response to external stimulus 0.03479 Highly Informative Inherited
Biological Process (BP) regulation of response to nutrient levels 1 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.002992 Highly Informative Inherited
Biological Process (BP) cell division 0.06307 Highly Informative Inherited
Molecular Function (MF) binding 1.387e-12 Least Informative Direct
Molecular Function (MF) transporter activity 2.054e-06 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0.004392 Moderately Informative Inherited
Molecular Function (MF) lipid binding 5.163e-07 Informative Direct
Molecular Function (MF) protein dimerization activity 0 Informative Direct
Molecular Function (MF) peptidase regulator activity 7.599e-05 Informative Direct
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 3.694e-08 Highly Informative Direct
Molecular Function (MF) protein heterodimerization activity 2.772e-10 Highly Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 2.972e-15 Least Informative Direct
Cellular Component (CC) intracellular organelle part 2.267e-08 Least Informative Direct
Cellular Component (CC) protein complex 0.001409 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.006774 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 9.067e-12 Moderately Informative Direct
Cellular Component (CC) cytosol 7.2e-08 Moderately Informative Direct
Cellular Component (CC) endomembrane system 4.341e-08 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 2.49e-05 Moderately Informative Direct
Cellular Component (CC) organelle envelope 0 Moderately Informative Direct
Cellular Component (CC) mitochondrial part 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.1633 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 3.041e-06 Informative Direct
Cellular Component (CC) integral to membrane 3.83e-14 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.01813 Informative Inherited
Cellular Component (CC) mitochondrial outer membrane 8.232e-06 Highly Informative Direct
Cellular Component (CC) centrosome 5.363e-05 Highly Informative Direct
Cellular Component (CC) pore complex 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.001027Least InformativeInherited
Disease Ontology (DO)immune system disease0.08606Least InformativeInherited
Disease Ontology (DO)nervous system disease0.5782Least InformativeInherited
Disease Ontology (DO)hematologic cancer0.001444Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.003164Moderately InformativeInherited
Disease Ontology (DO)cell type cancer0.01155Moderately InformativeInherited
Disease Ontology (DO)endocrine system disease0.03152Moderately InformativeInherited
Disease Ontology (DO)bacterial infectious disease0.09881Moderately InformativeInherited
Disease Ontology (DO)connective tissue cancer0.0001476InformativeDirect
Disease Ontology (DO)thyroid gland disease0.0008998InformativeDirect
Disease Ontology (DO)primary bacterial infectious disease0.002852InformativeInherited
Disease Ontology (DO)chronic leukemia0.01971InformativeInherited
Disease Ontology (DO)lymphoblastic leukemia0.04511InformativeInherited
Disease Ontology (DO)viral infectious disease0.08811InformativeInherited
Disease Ontology (DO)chronic lymphocytic leukemia3.326e-06Highly InformativeDirect
Disease Ontology (DO)Graves' disease0.000116Highly InformativeDirect
Disease Ontology (DO)tuberculosis0.0008763Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.01414Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.02246Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.1963Least InformativeInherited
Mammalian Phenotype (MP)abnormal leukopoiesis0.009214Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.01604Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.0549Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.06221Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell morphology0.06448Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal metencephalon morphology0.0003175InformativeDirect
Mammalian Phenotype (MP)abnormal mature B cell morphology0.001133InformativeInherited
Mammalian Phenotype (MP)abnormal lymphocyte cell number0.0157InformativeInherited
Mammalian Phenotype (MP)decreased hematopoietic cell number0.02457InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.07069InformativeInherited
Mammalian Phenotype (MP)abnormal immature B cell morphology0.0001912Highly InformativeDirect
Mammalian Phenotype (MP)abnormal autonomic nervous system morphology0.0006345Highly InformativeDirect
Mammalian Phenotype (MP)abnormal immune organ physiology0.01325Highly InformativeInherited
Mammalian Phenotype (MP)decreased B cell number0.09811Highly InformativeInherited

Document: MP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0Moderately InformativeDirect
Biological processHost-virus interaction3.528e-10Moderately InformativeDirect
Biological processDifferentiation0.0001614Moderately InformativeDirect
Biological processModulation of host cell apoptosis by virus0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus1.196e-07Least InformativeDirect
Cellular componentCytoplasm0.9342Least InformativeInherited
Cellular componentMitochondrion0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle7.414e-06Moderately InformativeDirect
Cellular componentCell junction1.549e-05Moderately InformativeDirect
Cellular componentEndoplasmic reticulum2.222e-05Moderately InformativeDirect
Cellular componentCytoskeleton0.0006234Moderately InformativeDirect
Cellular componentMitochondrion outer membrane4.129e-08InformativeDirect
Cellular componentSynapse2.253e-07InformativeDirect
DomainTransmembrane0Least InformativeDirect
Post-translational modificationDevelopmental protein0.0006052Moderately InformativeDirect
Post-translational modificationPhosphoprotein1.453e-05Least InformativeDirect
Post-translational modificationUbl conjugation9.749e-11Moderately InformativeDirect
Post-translational modificationIsopeptide bond0.0008954Moderately InformativeDirect

Document: KW annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 13 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Bcl-2 inhibitors of programmed cell death domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 13 hidden Markov models representing the Bcl-2 inhibitors of programmed cell death superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]