SUPERFAMILY 1.75 HMM library and genome assignments server

Bcl-2 inhibitors of programmed cell death superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Toxins' membrane translocation domains [ 56836] (5)
Superfamily:   Bcl-2 inhibitors of programmed cell death [ 56854]
Families:   Bcl-2 inhibitors of programmed cell death [ 56855] (10)


Superfamily statistics
Genomes (140) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,230 1,590 29
Proteins 1,222 1,582 29


Functional annotation
General category Processes_IC
Detailed category Cell cycle, Apoptosis

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)protein metabolic process0.00000000000074110.00000004814Least InformativeDirect
Biological Process (BP)multicellular organismal process0.000000000001620.00001445Least InformativeDirect
Biological Process (BP)developmental process0.000000000029150.00004081Least InformativeDirect
Biological Process (BP)single-organism cellular process0.000000000067510.000000000003739Least InformativeDirect
Biological Process (BP)positive regulation of biological process0.00051220.0009236Least InformativeDirect
Biological Process (BP)regulation of cellular process00Least InformativeDirect
Biological Process (BP)response to stimulus00.0000000000001834Least InformativeDirect
Biological Process (BP)localization0.000000039050.00009965Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis00.0000000002018Least InformativeDirect
Biological Process (BP)regulation of metabolic process0.20280.8969Least InformativeInherited
Biological Process (BP)immune system process0.00000000018820.000001125Moderately InformativeDirect
Biological Process (BP)signal transduction0.000000000022540.0000000002504Moderately InformativeDirect
Biological Process (BP)response to abiotic stimulus0.0000054680.0000136Moderately InformativeDirect
Biological Process (BP)positive regulation of metabolic process0.00023640.0007137Moderately InformativeDirect
Biological Process (BP)gene expression0.000000000008850.00000000005129Moderately InformativeDirect
Biological Process (BP)regulation of gene expression00Moderately InformativeDirect
Biological Process (BP)reproductive process00Moderately InformativeDirect
Biological Process (BP)cell differentiation0.00000000000011840.00000003664Moderately InformativeDirect
Biological Process (BP)cellular response to stress0.000000003840.0000000002906Moderately InformativeDirect
Biological Process (BP)positive regulation of cellular process0.000077530.0004531Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process0.0000012390.000002104Moderately InformativeDirect
Biological Process (BP)regulation of catalytic activity0.00000000000036690Moderately InformativeDirect
Biological Process (BP)regulation of protein metabolic process0.00000000000065090Moderately InformativeDirect
Biological Process (BP)multi-organism process0.0000000000024970.0000003485Moderately InformativeDirect
Biological Process (BP)regulation of biological quality0.00000010990.0000009239Moderately InformativeDirect
Biological Process (BP)single-organism organelle organization00.0000000000000742Moderately InformativeDirect
Biological Process (BP)positive regulation of response to stimulus0.010610.00002183Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.000033820.02438Moderately InformativeInherited
Biological Process (BP)response to organic substance0.61690.7617Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.57770.5266Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.95991Moderately InformativeInherited
Biological Process (BP)cellular localization0.0028470.0253Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.83910.9219Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.0044430.07938Moderately InformativeInherited
Biological Process (BP)response to external stimulus0.046030.06085Moderately InformativeInherited
Biological Process (BP)cellular component biogenesis11Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization11Moderately InformativeInherited
Biological Process (BP)organ development0.0000052680.01203Moderately InformativeInherited
Biological Process (BP)regulation of developmental process11Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.0065150.05404Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.78471Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function0.0012160.01962Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.0017050.04839Moderately InformativeInherited
Biological Process (BP)regulation of localization0.18020.2813Moderately InformativeInherited
Biological Process (BP)ion transport0.040290.06323Moderately InformativeInherited
Biological Process (BP)nervous system development0.69630.9784Moderately InformativeInherited
Biological Process (BP)regulation of phosphorus metabolic process0.91110.9168Moderately InformativeInherited
Biological Process (BP)tissue development0.12730.6431Moderately InformativeInherited
Biological Process (BP)regulation of protein phosphorylation0.00000000071730.000001911InformativeDirect
Biological Process (BP)apoptotic process00InformativeDirect
Biological Process (BP)mitochondrion organization00InformativeDirect
Biological Process (BP)cell proliferation00.000000000000009016InformativeDirect
Biological Process (BP)positive regulation of gene expression0.00000018150.000008697InformativeDirect
Biological Process (BP)positive regulation of cell death00InformativeDirect
Biological Process (BP)response to organic cyclic compound0.0000026910.00002276InformativeDirect
Biological Process (BP)cellular process involved in reproduction in multicellular organism0.000000000041970.0000000004898InformativeDirect
Biological Process (BP)response to nutrient levels0.00053090.000001706InformativeDirect
Biological Process (BP)positive regulation of cellular protein metabolic process0.0000000000039510.0000000001728InformativeDirect
Biological Process (BP)regulation of intracellular transport0.0000000017680.000000000451InformativeDirect
Biological Process (BP)regulation of organelle organization0.0000025730.00007036InformativeDirect
Biological Process (BP)ion transmembrane transport0.000000024260.000003239InformativeDirect
Biological Process (BP)tube development0.000051130.0009185InformativeDirect
Biological Process (BP)intracellular signal transduction0.000000085520.000000007915InformativeDirect
Biological Process (BP)growth0.0000025480.0004346InformativeDirect
Biological Process (BP)regulation of apoptotic process00InformativeDirect
Biological Process (BP)regulation of ion transport0.000033690.00001676InformativeDirect
Biological Process (BP)regulation of cellular component biogenesis0.0000084110.000236InformativeDirect
Biological Process (BP)single organism reproductive process00.000000000004754InformativeDirect
Biological Process (BP)single-organism membrane organization00InformativeDirect
Biological Process (BP)leukocyte activation0.000000068730.0000006102InformativeDirect
Biological Process (BP)hematopoietic or lymphoid organ development0.00000053960.000007996InformativeDirect
Biological Process (BP)reproductive structure development00.0000000000004894InformativeDirect
Biological Process (BP)multicellular organismal homeostasis0.000067470.000001601InformativeDirect
Biological Process (BP)positive regulation of cellular component organization0.0000095630.000284InformativeDirect
Biological Process (BP)protein oligomerization0.000000033380.0000002285InformativeDirect
Biological Process (BP)positive regulation of hydrolase activity0.00000056470.0001548InformativeDirect
Biological Process (BP)protein maturation00InformativeDirect
Biological Process (BP)regulation of peptidase activity00InformativeDirect
Biological Process (BP)cation homeostasis0.0000000000000063590.00000000001408InformativeDirect
Biological Process (BP)epithelium development0.00000000016030.00004473InformativeDirect
Biological Process (BP)negative regulation of cell death0.0000000012230InformativeDirect
Biological Process (BP)positive regulation of intracellular signal transduction0.0043950.0002096InformativeInherited
Biological Process (BP)tissue morphogenesis0.000017810.001332InformativeInherited
Biological Process (BP)regulation of mitotic cell cycle0.84020.9604InformativeInherited
Biological Process (BP)regulation of cell cycle process0.96391InformativeInherited
Biological Process (BP)cellular chemical homeostasis0.00049260.03354InformativeInherited
Biological Process (BP)cellular response to nitrogen compound0.0027040.009188InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound0.25520.1903InformativeInherited
Biological Process (BP)protein localization to organelle0.028680.02472InformativeInherited
Biological Process (BP)response to lipid0.5650.4869InformativeInherited
Biological Process (BP)anatomical structure homeostasis0.014050.002435InformativeInherited
Biological Process (BP)organ morphogenesis0.00083120.07392InformativeInherited
Biological Process (BP)sensory organ development0.000014690.001503InformativeInherited
Biological Process (BP)cardiovascular system development0.038610.05257InformativeInherited
Biological Process (BP)single-organism intracellular transport0.00050040.002155InformativeInherited
Biological Process (BP)response to organonitrogen compound0.0031030.008959InformativeInherited
Biological Process (BP)response to acid chemical0.12920.09782InformativeInherited
Biological Process (BP)embryo development ending in birth or egg hatching0.082910.04292InformativeInherited
Biological Process (BP)cellular component morphogenesis0.0040560.1672InformativeInherited
Biological Process (BP)positive regulation of transport0.01590.01569InformativeInherited
Biological Process (BP)multicellular organismal reproductive process0.026170.374InformativeInherited
Biological Process (BP)positive regulation of developmental process0.64380.9063InformativeInherited
Biological Process (BP)regulation of cell development0.0000098550.00489InformativeInherited
Biological Process (BP)response to light stimulus11InformativeInherited
Biological Process (BP)central nervous system development0.0012720.004356InformativeInherited
Biological Process (BP)sexual reproduction0.067990.7724InformativeInherited
Biological Process (BP)negative regulation of cellular protein metabolic process0.34770.003529InformativeInherited
Biological Process (BP)anatomical structure formation involved in morphogenesis0.019940.1912InformativeInherited
Biological Process (BP)cell division0.043330.403InformativeInherited
Biological Process (BP)organelle fission0.0025470.02661InformativeInherited
Biological Process (BP)cell cycle process0.26420.8481InformativeInherited
Biological Process (BP)cytokinesis0.0000023470.00006402Highly InformativeDirect
Biological Process (BP)angiogenesis0.000012160.000009043Highly InformativeDirect
Biological Process (BP)leukocyte homeostasis00Highly InformativeDirect
Biological Process (BP)negative regulation of protein phosphorylation0.00039910.0001752Highly InformativeDirect
Biological Process (BP)mitochondrial transport00Highly InformativeDirect
Biological Process (BP)cellular calcium ion homeostasis00Highly InformativeDirect
Biological Process (BP)mitochondrial membrane organization0.0000000000000032510Highly InformativeDirect
Biological Process (BP)germ cell development0.0000045590.0001359Highly InformativeDirect
Biological Process (BP)spermatogenesis0.0000000000000032510.0000000001539Highly InformativeDirect
Biological Process (BP)gonad development00Highly InformativeDirect
Biological Process (BP)response to UV0.0000000000015890.000000000206Highly InformativeDirect
Biological Process (BP)fertilization0.000061330.00002777Highly InformativeDirect
Biological Process (BP)response to virus0.000087660.0002096Highly InformativeDirect
Biological Process (BP)response to toxic substance00Highly InformativeDirect
Biological Process (BP)response to ionizing radiation0.00000000000058690.00000000000011Highly InformativeDirect
Biological Process (BP)positive regulation of organelle organization0.0000000048680.00000003123Highly InformativeDirect
Biological Process (BP)regulation of mitochondrion organization00Highly InformativeDirect
Biological Process (BP)positive regulation of endopeptidase activity0.000000000056410.00004681Highly InformativeDirect
Biological Process (BP)ovulation cycle process00Highly InformativeDirect
Biological Process (BP)zymogen activation00Highly InformativeDirect
Biological Process (BP)positive regulation of intracellular transport0.000018760.000001362Highly InformativeDirect
Biological Process (BP)negative regulation of homeostatic process0.000011080.000003654Highly InformativeDirect
Biological Process (BP)positive regulation of homeostatic process0.0000056290.00001688Highly InformativeDirect
Biological Process (BP)response to endoplasmic reticulum stress00.00000000000006627Highly InformativeDirect
Biological Process (BP)limb morphogenesis0.00000000000001550.0000000003259Highly InformativeDirect
Biological Process (BP)B cell activation0.000080520.00003053Highly InformativeDirect
Biological Process (BP)regulation of membrane potential00Highly InformativeDirect
Biological Process (BP)response to amino acid0.000000096190.00000008396Highly InformativeDirect
Biological Process (BP)regulation of protein complex assembly0.00000039120.00000002083Highly InformativeDirect
Biological Process (BP)response to alkaloid0.0000000015540.000000008056Highly InformativeDirect
Biological Process (BP)regulation of cysteine-type endopeptidase activity involved in apoptotic process0.00000000052590.00000000004365Highly InformativeDirect
Biological Process (BP)regulation of neuron apoptotic process0.0006030.00002741Highly InformativeDirect
Biological Process (BP)positive regulation of cellular component biogenesis0.000000031730.000001068Highly InformativeDirect
Biological Process (BP)organelle fusion0.000000000000012480Highly InformativeDirect
Biological Process (BP)eye morphogenesis0.000023410.0000489Highly InformativeDirect
Biological Process (BP)response to axon injury0.00000000058990.0000000004638Highly InformativeDirect
Biological Process (BP)branching morphogenesis of an epithelial tube00.0000000000009801Highly InformativeDirect
Biological Process (BP)regulation of binding0.00000015560.0000058Highly InformativeDirect
Biological Process (BP)protein homooligomerization0.0000000045380.000000008498Highly InformativeDirect
Biological Process (BP)response to glucocorticoid0.00000021850.0000002753Highly InformativeDirect
Biological Process (BP)regulation of calcium ion transport00Highly InformativeDirect
Biological Process (BP)membrane fusion0.00012630.00001174Highly InformativeDirect
Biological Process (BP)mitochondrion morphogenesis0.000000012760.0000000000001561Highly InformativeDirect
Biological Process (BP)protein localization to mitochondrion0.000000071810.00000006111Highly InformativeDirect
Biological Process (BP)cellular response to acid chemical0.0001910.00008747Highly InformativeDirect
Biological Process (BP)cellular response to radiation0.000020330.00006708Highly InformativeDirect
Biological Process (BP)regulation of cellular response to stress0.00000027250.0000000002745Highly InformativeDirect
Biological Process (BP)regulation of membrane permeability00Highly InformativeDirect
Biological Process (BP)extrinsic apoptotic signaling pathway00Highly InformativeDirect
Biological Process (BP)intrinsic apoptotic signaling pathway00Highly InformativeDirect
Biological Process (BP)cell-type specific apoptotic process0.0000000000090280.0000000139Highly InformativeDirect
Biological Process (BP)positive regulation of neuron death0.00041740.000009323Highly InformativeDirect
Biological Process (BP)regulation of ion homeostasis00Highly InformativeDirect
Biological Process (BP)positive regulation of apoptotic signaling pathway0.00000000070390.0000000000003216Highly InformativeDirect
Biological Process (BP)regulation of intrinsic apoptotic signaling pathway00Highly InformativeDirect
Biological Process (BP)pattern specification process0.0000093920.006546Highly InformativeInherited
Biological Process (BP)post-embryonic organ development0.0000029110.001575Highly InformativeInherited
Biological Process (BP)post-embryonic development0.000037310.00328Highly InformativeInherited
Biological Process (BP)positive regulation of ion transport0.0060010.002361Highly InformativeInherited
Biological Process (BP)development of primary female sexual characteristics0.060860.004488Highly InformativeInherited
Molecular Function (MF)binding00.000000000005275Least InformativeDirect
Molecular Function (MF)transporter activity0.0000010940.00001015Moderately InformativeDirect
Molecular Function (MF)enzyme regulator activity0.018150.002825Moderately InformativeInherited
Molecular Function (MF)lipid binding0.0000019690.0000007929InformativeDirect
Molecular Function (MF)protein dimerization activity00InformativeDirect
Molecular Function (MF)peptidase regulator activity0.00035790.0002612InformativeDirect
Molecular Function (MF)protein domain specific binding00Highly InformativeDirect
Molecular Function (MF)cysteine-type endopeptidase regulator activity involved in apoptotic process0.00000029720.0000001067Highly InformativeDirect
Molecular Function (MF)protein heterodimerization activity00.00000000003387Highly InformativeDirect
Cellular Component (CC)membrane00Least InformativeDirect
Cellular Component (CC)cytoplasmic part0.0000000044820Least InformativeDirect
Cellular Component (CC)intracellular organelle part0.000000000000018630.0000000155Least InformativeDirect
Cellular Component (CC)protein complex0.0000052270.00289Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.0038380.003063Least InformativeInherited
Cellular Component (CC)non-membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)endoplasmic reticulum0.0000000000022950.00000000005055Moderately InformativeDirect
Cellular Component (CC)cytosol0.0000034030.000001275Moderately InformativeDirect
Cellular Component (CC)intrinsic component of membrane0.0000010280.00001759Moderately InformativeDirect
Cellular Component (CC)organelle envelope00Moderately InformativeDirect
Cellular Component (CC)mitochondrial part00Moderately InformativeDirect
Cellular Component (CC)cytoskeleton0.17470.2732Moderately InformativeInherited
Cellular Component (CC)membrane region0.00014730.005182Moderately InformativeInherited
Cellular Component (CC)bounding membrane of organelle0.0013970.04672Moderately InformativeInherited
Cellular Component (CC)endoplasmic reticulum membrane0.000003960.000002631InformativeDirect
Cellular Component (CC)integral component of membrane0.00000018670.000003511InformativeDirect
Cellular Component (CC)microtubule cytoskeleton0.0011980.03236InformativeInherited
Cellular Component (CC)microtubule organizing center0.000010470.0006429Highly InformativeDirect
Cellular Component (CC)organelle outer membrane00Highly InformativeDirect
Cellular Component (CC)pore complex00Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0.00000004814 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.00001445 Least Informative Direct
Biological Process (BP) developmental process 0.00004081 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.000000000003739 Least Informative Direct
Biological Process (BP) positive regulation of biological process 0.0009236 Least Informative Direct
Biological Process (BP) regulation of cellular process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0.0000000000001834 Least Informative Direct
Biological Process (BP) localization 0.00009965 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.0000000002018 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.8969 Least Informative Inherited
Biological Process (BP) immune system process 0.000001125 Moderately Informative Direct
Biological Process (BP) signal transduction 0.0000000002504 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.0000136 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0.0007137 Moderately Informative Direct
Biological Process (BP) gene expression 0.00000000005129 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0 Moderately Informative Direct
Biological Process (BP) reproductive process 0 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.00000003664 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.0000000002906 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.0004531 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.000002104 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 0.00002183 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.0000003485 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.0000009239 Moderately Informative Direct
Biological Process (BP) single-organism organelle organization 0.0000000000000742 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.02438 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.7617 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.5266 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.0253 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.9219 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.07938 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.06085 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) organ development 0.01203 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.05404 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.01962 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.04839 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.2813 Moderately Informative Inherited
Biological Process (BP) ion transport 0.06323 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.9784 Moderately Informative Inherited
Biological Process (BP) regulation of phosphorus metabolic process 0.9168 Moderately Informative Inherited
Biological Process (BP) tissue development 0.6431 Moderately Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.000001911 Informative Direct
Biological Process (BP) apoptotic process 0 Informative Direct
Biological Process (BP) mitochondrion organization 0 Informative Direct
Biological Process (BP) cell proliferation 0.000000000000009016 Informative Direct
Biological Process (BP) positive regulation of gene expression 0.000008697 Informative Direct
Biological Process (BP) positive regulation of cell death 0 Informative Direct
Biological Process (BP) response to organic cyclic compound 0.00002276 Informative Direct
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.0000000004898 Informative Direct
Biological Process (BP) response to nutrient levels 0.000001706 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 0.0000000001728 Informative Direct
Biological Process (BP) regulation of intracellular transport 0.000000000451 Informative Direct
Biological Process (BP) regulation of organelle organization 0.00007036 Informative Direct
Biological Process (BP) ion transmembrane transport 0.000003239 Informative Direct
Biological Process (BP) tube development 0.0009185 Informative Direct
Biological Process (BP) intracellular signal transduction 0.000000007915 Informative Direct
Biological Process (BP) growth 0.0004346 Informative Direct
Biological Process (BP) regulation of apoptotic process 0 Informative Direct
Biological Process (BP) regulation of ion transport 0.00001676 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.000236 Informative Direct
Biological Process (BP) single organism reproductive process 0.000000000004754 Informative Direct
Biological Process (BP) single-organism membrane organization 0 Informative Direct
Biological Process (BP) leukocyte activation 0.0000006102 Informative Direct
Biological Process (BP) hematopoietic or lymphoid organ development 0.000007996 Informative Direct
Biological Process (BP) reproductive structure development 0.0000000000004894 Informative Direct
Biological Process (BP) multicellular organismal homeostasis 0.000001601 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.000284 Informative Direct
Biological Process (BP) protein oligomerization 0.0000002285 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.0001548 Informative Direct
Biological Process (BP) protein maturation 0 Informative Direct
Biological Process (BP) regulation of peptidase activity 0 Informative Direct
Biological Process (BP) cation homeostasis 0.00000000001408 Informative Direct
Biological Process (BP) epithelium development 0.00004473 Informative Direct
Biological Process (BP) negative regulation of cell death 0 Informative Direct
Biological Process (BP) positive regulation of intracellular signal transduction 0.0002096 Informative Direct
Biological Process (BP) tissue morphogenesis 0.001332 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.9604 Informative Inherited
Biological Process (BP) regulation of cell cycle process 1 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.03354 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.009188 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.1903 Informative Inherited
Biological Process (BP) protein localization to organelle 0.02472 Informative Inherited
Biological Process (BP) response to lipid 0.4869 Informative Inherited
Biological Process (BP) anatomical structure homeostasis 0.002435 Informative Inherited
Biological Process (BP) organ morphogenesis 0.07392 Informative Inherited
Biological Process (BP) sensory organ development 0.001503 Informative Inherited
Biological Process (BP) cardiovascular system development 0.05257 Informative Inherited
Biological Process (BP) single-organism intracellular transport 0.002155 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.008959 Informative Inherited
Biological Process (BP) response to acid chemical 0.09782 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.04292 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.1672 Informative Inherited
Biological Process (BP) positive regulation of transport 0.01569 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.7134 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.374 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 0.08642 Informative Inherited
Biological Process (BP) positive regulation of catabolic process 0.328 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.9063 Informative Inherited
Biological Process (BP) regulation of cell development 0.00489 Informative Inherited
Biological Process (BP) response to light stimulus 1 Informative Inherited
Biological Process (BP) central nervous system development 0.004356 Informative Inherited
Biological Process (BP) sexual reproduction 0.7724 Informative Inherited
Biological Process (BP) negative regulation of cellular protein metabolic process 0.003529 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.1912 Informative Inherited
Biological Process (BP) cell division 0.403 Informative Inherited
Biological Process (BP) organelle fission 0.02661 Informative Inherited
Biological Process (BP) cell cycle process 0.8481 Informative Inherited
Biological Process (BP) cytokinesis 0.00006402 Highly Informative Direct
Biological Process (BP) angiogenesis 0.000009043 Highly Informative Direct
Biological Process (BP) leukocyte homeostasis 0 Highly Informative Direct
Biological Process (BP) negative regulation of protein phosphorylation 0.0001752 Highly Informative Direct
Biological Process (BP) mitochondrial transport 0 Highly Informative Direct
Biological Process (BP) cellular calcium ion homeostasis 0 Highly Informative Direct
Biological Process (BP) mitochondrial membrane organization 0 Highly Informative Direct
Biological Process (BP) germ cell development 0.0001359 Highly Informative Direct
Biological Process (BP) spermatogenesis 0.0000000001539 Highly Informative Direct
Biological Process (BP) gonad development 0 Highly Informative Direct
Biological Process (BP) response to UV 0.000000000206 Highly Informative Direct
Biological Process (BP) fertilization 0.00002777 Highly Informative Direct
Biological Process (BP) response to virus 0.0002096 Highly Informative Direct
Biological Process (BP) response to toxic substance 0 Highly Informative Direct
Biological Process (BP) response to ionizing radiation 0.00000000000011 Highly Informative Direct
Biological Process (BP) regulation of autophagy 0.000001654 Highly Informative Direct
Biological Process (BP) positive regulation of organelle organization 0.00000003123 Highly Informative Direct
Biological Process (BP) regulation of mitochondrion organization 0 Highly Informative Direct
Biological Process (BP) positive regulation of endopeptidase activity 0.00004681 Highly Informative Direct
Biological Process (BP) ovulation cycle process 0 Highly Informative Direct
Biological Process (BP) zymogen activation 0 Highly Informative Direct
Biological Process (BP) positive regulation of intracellular transport 0.000001362 Highly Informative Direct
Biological Process (BP) negative regulation of homeostatic process 0.000003654 Highly Informative Direct
Biological Process (BP) positive regulation of homeostatic process 0.00001688 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0.00000000000006627 Highly Informative Direct
Biological Process (BP) limb morphogenesis 0.0000000003259 Highly Informative Direct
Biological Process (BP) B cell activation 0.00003053 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 0 Highly Informative Direct
Biological Process (BP) response to amino acid 0.00000008396 Highly Informative Direct
Biological Process (BP) regulation of protein complex assembly 0.00000002083 Highly Informative Direct
Biological Process (BP) response to alkaloid 0.000000008056 Highly Informative Direct
Biological Process (BP) regulation of cysteine-type endopeptidase activity involved in apoptotic process 0.00000000004365 Highly Informative Direct
Biological Process (BP) regulation of neuron apoptotic process 0.00002741 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0.000001068 Highly Informative Direct
Biological Process (BP) organelle fusion 0 Highly Informative Direct
Biological Process (BP) eye morphogenesis 0.0000489 Highly Informative Direct
Biological Process (BP) response to axon injury 0.0000000004638 Highly Informative Direct
Biological Process (BP) branching morphogenesis of an epithelial tube 0.0000000000009801 Highly Informative Direct
Biological Process (BP) regulation of binding 0.0000058 Highly Informative Direct
Biological Process (BP) protein homooligomerization 0.000000008498 Highly Informative Direct
Biological Process (BP) response to glucocorticoid 0.0000002753 Highly Informative Direct
Biological Process (BP) regulation of calcium ion transport 0 Highly Informative Direct
Biological Process (BP) membrane fusion 0.00001174 Highly Informative Direct
Biological Process (BP) mitochondrion morphogenesis 0.0000000000001561 Highly Informative Direct
Biological Process (BP) protein localization to mitochondrion 0.00000006111 Highly Informative Direct
Biological Process (BP) cellular response to acid chemical 0.00008747 Highly Informative Direct
Biological Process (BP) cellular response to radiation 0.00006708 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.0000000002745 Highly Informative Direct
Biological Process (BP) regulation of membrane permeability 0 Highly Informative Direct
Biological Process (BP) extrinsic apoptotic signaling pathway 0 Highly Informative Direct
Biological Process (BP) intrinsic apoptotic signaling pathway 0 Highly Informative Direct
Biological Process (BP) cell-type specific apoptotic process 0.0000000139 Highly Informative Direct
Biological Process (BP) positive regulation of neuron death 0.000009323 Highly Informative Direct
Biological Process (BP) regulation of ion homeostasis 0 Highly Informative Direct
Biological Process (BP) positive regulation of apoptotic signaling pathway 0.0000000000003216 Highly Informative Direct
Biological Process (BP) regulation of intrinsic apoptotic signaling pathway 0 Highly Informative Direct
Biological Process (BP) pattern specification process 0.006546 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.001575 Highly Informative Inherited
Biological Process (BP) positive regulation of response to external stimulus 0.09712 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.00328 Highly Informative Inherited
Biological Process (BP) regulation of response to nutrient levels 1 Highly Informative Inherited
Biological Process (BP) positive regulation of ion transport 0.002361 Highly Informative Inherited
Biological Process (BP) development of primary female sexual characteristics 0.004488 Highly Informative Inherited
Molecular Function (MF) binding 0.000000000005275 Least Informative Direct
Molecular Function (MF) transporter activity 0.00001015 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0.002825 Moderately Informative Inherited
Molecular Function (MF) lipid binding 0.0000007929 Informative Direct
Molecular Function (MF) protein dimerization activity 0 Informative Direct
Molecular Function (MF) peptidase regulator activity 0.0002612 Informative Direct
Molecular Function (MF) protein domain specific binding 0 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 0.0000001067 Highly Informative Direct
Molecular Function (MF) protein heterodimerization activity 0.00000000003387 Highly Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.0000000155 Least Informative Direct
Cellular Component (CC) protein complex 0.00289 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.003063 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.00000000005055 Moderately Informative Direct
Cellular Component (CC) cytosol 0.000001275 Moderately Informative Direct
Cellular Component (CC) intrinsic component of membrane 0.00001759 Moderately Informative Direct
Cellular Component (CC) organelle envelope 0 Moderately Informative Direct
Cellular Component (CC) mitochondrial part 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.2732 Moderately Informative Inherited
Cellular Component (CC) membrane region 0.005182 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 0.04672 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 0.000002631 Informative Direct
Cellular Component (CC) integral component of membrane 0.000003511 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.03236 Informative Inherited
Cellular Component (CC) microtubule organizing center 0.0006429 Highly Informative Direct
Cellular Component (CC) organelle outer membrane 0 Highly Informative Direct
Cellular Component (CC) pore complex 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.002131Least InformativeInherited
Disease Ontology (DO)hematologic cancer0.004355Moderately InformativeInherited
Disease Ontology (DO)connective tissue cancer0.00086InformativeDirect
Disease Ontology (DO)lymphoblastic leukemia0.08569InformativeInherited
Disease Ontology (DO)viral infectious disease0.1318InformativeInherited

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.005423Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.008853Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.1364Least InformativeInherited
Mammalian Phenotype (MP)abnormal leukopoiesis0.005426Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.009641Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.03611Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.04209Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.1709Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal metencephalon morphology0.0001935InformativeDirect
Mammalian Phenotype (MP)abnormal mature B cell morphology0.0007164InformativeDirect
Mammalian Phenotype (MP)decreased germ cell number0.001668InformativeInherited
Mammalian Phenotype (MP)decreased leukocyte cell number0.008739InformativeInherited
Mammalian Phenotype (MP)abnormal lymphocyte cell number0.009172InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.066InformativeInherited
Mammalian Phenotype (MP)abnormal gametes0.5051InformativeInherited
Mammalian Phenotype (MP)abnormal immature B cell morphology0.00003853Highly InformativeDirect
Mammalian Phenotype (MP)decreased mature B cell number0.0002624Highly InformativeDirect
Mammalian Phenotype (MP)abnormal autonomic nervous system morphology0.0005668Highly InformativeDirect
Mammalian Phenotype (MP)abnormal immune organ physiology0.01328Highly InformativeInherited

Document: MP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0Moderately InformativeDirect
Biological processHost-virus interaction0.0000000003481Moderately InformativeDirect
Biological processDifferentiation0.000174Moderately InformativeDirect
Biological processModulation of host cell apoptosis by virus0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus0.0000001301Least InformativeDirect
Cellular componentCytoplasm0.9415Least InformativeInherited
Cellular componentMitochondrion0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.0000082Moderately InformativeDirect
Cellular componentCell junction0.00001648Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.00002589Moderately InformativeDirect
Cellular componentCytoskeleton0.0006389Moderately InformativeDirect
Cellular componentMitochondrion outer membrane0.00000004737InformativeDirect
Cellular componentSynapse0.0000002578InformativeDirect
DomainTransmembrane0Least InformativeDirect
Post-translational modificationDevelopmental protein0.0005953Moderately InformativeDirect
Post-translational modificationPhosphoprotein0.00001458Least InformativeDirect
Post-translational modificationUbl conjugation0.0000000001272Moderately InformativeDirect

Document: KW annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 13 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Bcl-2 inhibitors of programmed cell death domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 13 hidden Markov models representing the Bcl-2 inhibitors of programmed cell death superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]