SUPERFAMILY 1.75 HMM library and genome assignments server


Bcl-2 inhibitors of programmed cell death superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Toxins' membrane translocation domains [ 56836] (5)
Superfamily:   Bcl-2 inhibitors of programmed cell death [ 56854]
Families:   Bcl-2 inhibitors of programmed cell death [ 56855] (10)


Superfamily statistics
Genomes (140) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,230 1,590 29
Proteins 1,222 1,582 29


Functional annotation
General category Processes_IC
Detailed category Cell cycle, Apoptosis

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process1.001e-121.756e-05Least InformativeDirect
Biological Process (BP)developmental process6.683e-121.8e-05Least InformativeDirect
Biological Process (BP)single-organism cellular process00Least InformativeDirect
Biological Process (BP)regulation of cellular process00Least InformativeDirect
Biological Process (BP)response to stimulus01.644e-13Least InformativeDirect
Biological Process (BP)localization5.306e-092.43e-05Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis02.098e-11Least InformativeDirect
Biological Process (BP)regulation of metabolic process0.10830.7351Least InformativeInherited
Biological Process (BP)reproduction01.944e-15Moderately InformativeDirect
Biological Process (BP)immune system process2.399e-101.187e-06Moderately InformativeDirect
Biological Process (BP)organelle organization01.17e-09Moderately InformativeDirect
Biological Process (BP)signal transduction1.564e-106.946e-10Moderately InformativeDirect
Biological Process (BP)response to abiotic stimulus5.129e-061.153e-05Moderately InformativeDirect
Biological Process (BP)cell differentiation1.085e-133.024e-08Moderately InformativeDirect
Biological Process (BP)cellular response to stress3.438e-091.787e-10Moderately InformativeDirect
Biological Process (BP)regulation of programmed cell death00Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process3.428e-061.72e-05Moderately InformativeDirect
Biological Process (BP)regulation of catalytic activity8.688e-130Moderately InformativeDirect
Biological Process (BP)regulation of protein metabolic process1.119e-050.0002018Moderately InformativeDirect
Biological Process (BP)multi-organism process9.119e-082.38e-05Moderately InformativeDirect
Biological Process (BP)positive regulation of response to stimulus0.020830.0001441Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction3.186e-050.03063Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.56140.5019Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.95331Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.90580.9945Moderately InformativeInherited
Biological Process (BP)cellular localization0.010240.08532Moderately InformativeInherited
Biological Process (BP)tissue development0.19140.6911Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.0060890.051Moderately InformativeInherited
Biological Process (BP)response to organic substance0.58160.7338Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization0.87450.5559Moderately InformativeInherited
Biological Process (BP)cellular component biogenesis11Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.0026430.05979Moderately InformativeInherited
Biological Process (BP)organ development3.011e-050.02629Moderately InformativeInherited
Biological Process (BP)regulation of developmental process11Moderately InformativeInherited
Biological Process (BP)regulation of localization0.16570.2632Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.0010230.03353Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function0.0010660.01558Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.00012040.002802Moderately InformativeInherited
Biological Process (BP)ion transport0.0036130.01226Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process19.285e-05Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.95661Moderately InformativeInherited
Biological Process (BP)homeostatic process0.71010.3832Moderately InformativeInherited
Biological Process (BP)regulation of protein phosphorylation5.2e-101.403e-06InformativeDirect
Biological Process (BP)developmental process involved in reproduction8.863e-121.352e-13InformativeDirect
Biological Process (BP)apoptotic process00InformativeDirect
Biological Process (BP)mitochondrion organization00InformativeDirect
Biological Process (BP)response to organic cyclic compound3.312e-062.411e-05InformativeDirect
Biological Process (BP)cellular membrane organization00InformativeDirect
Biological Process (BP)cellular cation homeostasis01.049e-12InformativeDirect
Biological Process (BP)response to nutrient levels0.00040399.391e-07InformativeDirect
Biological Process (BP)regulation of intracellular transport1.642e-095.27e-10InformativeDirect
Biological Process (BP)regulation of organelle organization2.37e-062.63e-05InformativeDirect
Biological Process (BP)tube development1.482e-050.0001971InformativeDirect
Biological Process (BP)intracellular signal transduction4.69e-082.155e-09InformativeDirect
Biological Process (BP)growth2.272e-060.000385InformativeDirect
Biological Process (BP)regulation of ion transport3.959e-051.467e-05InformativeDirect
Biological Process (BP)regulation of cellular component biogenesis6.706e-060.0001528InformativeDirect
Biological Process (BP)single organism reproductive process5.021e-093.299e-05InformativeDirect
Biological Process (BP)leukocyte activation7.036e-086.314e-07InformativeDirect
Biological Process (BP)hematopoietic or lymphoid organ development5.709e-064.14e-05InformativeDirect
Biological Process (BP)cellular process involved in reproduction7.635e-113.866e-09InformativeDirect
Biological Process (BP)positive regulation of cellular component organization2.763e-067.41e-05InformativeDirect
Biological Process (BP)positive regulation of hydrolase activity5.874e-070.0001087InformativeDirect
Biological Process (BP)regulation of peptidase activity00InformativeDirect
Biological Process (BP)metal ion homeostasis07.233e-13InformativeDirect
Biological Process (BP)transmembrane transport2.033e-062.879e-07InformativeDirect
Biological Process (BP)epithelium development2.276e-101.705e-05InformativeDirect
Biological Process (BP)negative regulation of cell death5.606e-083.77e-15InformativeDirect
Biological Process (BP)reproductive system development00InformativeDirect
Biological Process (BP)regulation of apoptotic signaling pathway2.933e-106.174e-11InformativeDirect
Biological Process (BP)positive regulation of signal transduction0.0025630.02356InformativeInherited
Biological Process (BP)tissue morphogenesis2.834e-050.001441InformativeInherited
Biological Process (BP)cardiovascular system development0.03750.05106InformativeInherited
Biological Process (BP)regulation of mitotic cell cycle0.70610.8255InformativeInherited
Biological Process (BP)regulation of cell cycle process0.96181InformativeInherited
Biological Process (BP)protein localization to organelle0.02760.02522InformativeInherited
Biological Process (BP)cellular response to endogenous stimulus0.78910.9887InformativeInherited
Biological Process (BP)response to organonitrogen compound0.0035330.009572InformativeInherited
Biological Process (BP)cellular response to nitrogen compound0.0027640.009247InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound0.25060.1858InformativeInherited
Biological Process (BP)response to other organism0.041050.05427InformativeInherited
Biological Process (BP)response to hormone stimulus0.66360.6621InformativeInherited
Biological Process (BP)response to lipid0.54930.4755InformativeInherited
Biological Process (BP)protein complex assembly0.49810.213InformativeInherited
Biological Process (BP)response to wounding0.55810.8266InformativeInherited
Biological Process (BP)sensory organ development9.623e-050.00535InformativeInherited
Biological Process (BP)organ morphogenesis0.0044420.1802InformativeInherited
Biological Process (BP)positive regulation of developmental process0.55480.7485InformativeInherited
Biological Process (BP)positive regulation of transport0.20880.1943InformativeInherited
Biological Process (BP)embryo development ending in birth or egg hatching0.14740.09644InformativeInherited
Biological Process (BP)negative regulation of protein metabolic process0.0052630.0002605InformativeInherited
Biological Process (BP)cellular component morphogenesis0.0035350.1704InformativeInherited
Biological Process (BP)regulation of cellular catabolic process0.34310.0004833InformativeInherited
Biological Process (BP)response to light stimulus11InformativeInherited
Biological Process (BP)response to DNA damage stimulus0.04040.06826InformativeInherited
Biological Process (BP)multicellular organismal reproductive process0.05890.5238InformativeInherited
Biological Process (BP)sexual reproduction0.1070.5628InformativeInherited
Biological Process (BP)anatomical structure formation involved in morphogenesis0.023040.2059InformativeInherited
Biological Process (BP)cell cycle process0.53320.9537InformativeInherited
Biological Process (BP)response to acid1.86e-092.438e-10Highly InformativeDirect
Biological Process (BP)angiogenesis7.77e-053.457e-05Highly InformativeDirect
Biological Process (BP)leukocyte homeostasis00Highly InformativeDirect
Biological Process (BP)mitochondrial transport00Highly InformativeDirect
Biological Process (BP)cellular calcium ion homeostasis00Highly InformativeDirect
Biological Process (BP)mitochondrial membrane organization7.219e-098.982e-12Highly InformativeDirect
Biological Process (BP)spermatogenesis3.321e-151.328e-10Highly InformativeDirect
Biological Process (BP)gonad development00Highly InformativeDirect
Biological Process (BP)response to UV1.295e-121.62e-10Highly InformativeDirect
Biological Process (BP)fertilization1.074e-058.307e-07Highly InformativeDirect
Biological Process (BP)response to virus0.00013120.0002418Highly InformativeDirect
Biological Process (BP)response to toxic substance00Highly InformativeDirect
Biological Process (BP)response to ionizing radiation5.241e-139.131e-14Highly InformativeDirect
Biological Process (BP)regulation of autophagy2.369e-052.833e-07Highly InformativeDirect
Biological Process (BP)positive regulation of organelle organization9.229e-102.217e-09Highly InformativeDirect
Biological Process (BP)regulation of mitochondrion organization00Highly InformativeDirect
Biological Process (BP)positive regulation of endopeptidase activity4.007e-113.717e-05Highly InformativeDirect
Biological Process (BP)cellular process involved in reproduction in multicellular organism4.024e-051.168e-05Highly InformativeDirect
Biological Process (BP)ovulation cycle process00Highly InformativeDirect
Biological Process (BP)negative regulation of protein modification process0.00074370.0005073Highly InformativeDirect
Biological Process (BP)positive regulation of homeostatic process2.681e-066.445e-07Highly InformativeDirect
Biological Process (BP)ion transmembrane transport1.007e-103.194e-08Highly InformativeDirect
Biological Process (BP)response to endoplasmic reticulum stress03.801e-14Highly InformativeDirect
Biological Process (BP)limb morphogenesis4.86e-143.328e-09Highly InformativeDirect
Biological Process (BP)modification of morphology or physiology of other organism2.589e-061.103e-05Highly InformativeDirect
Biological Process (BP)B cell activation8.118e-052.862e-05Highly InformativeDirect
Biological Process (BP)negative regulation of phosphorylation0.00048250.0003133Highly InformativeDirect
Biological Process (BP)regulation of membrane potential02.125e-14Highly InformativeDirect
Biological Process (BP)positive regulation of programmed cell death3.957e-070.0002492Highly InformativeDirect
Biological Process (BP)regulation of protein complex assembly7.484e-072.861e-08Highly InformativeDirect
Biological Process (BP)positive regulation of ion transport0.00017837.229e-05Highly InformativeDirect
Biological Process (BP)response to alkaloid1.685e-098.804e-09Highly InformativeDirect
Biological Process (BP)regulation of cysteine-type endopeptidase activity involved in apoptotic process2.67e-101.517e-11Highly InformativeDirect
Biological Process (BP)regulation of neuron apoptotic process0.00085038.945e-05Highly InformativeDirect
Biological Process (BP)symbiosis, encompassing mutualism through parasitism2.365e-115.733e-09Highly InformativeDirect
Biological Process (BP)multi-organism cellular process4.204e-078.941e-06Highly InformativeDirect
Biological Process (BP)development of primary female sexual characteristics0.00029282.234e-06Highly InformativeDirect
Biological Process (BP)organelle fusion4.957e-150Highly InformativeDirect
Biological Process (BP)eye morphogenesis1.803e-055.013e-05Highly InformativeDirect
Biological Process (BP)response to axon injury6.312e-104.605e-10Highly InformativeDirect
Biological Process (BP)branching morphogenesis of an epithelial tube01.141e-12Highly InformativeDirect
Biological Process (BP)regulation of binding8.593e-084.329e-06Highly InformativeDirect
Biological Process (BP)protein homooligomerization4.376e-098.068e-09Highly InformativeDirect
Biological Process (BP)response to glucocorticoid stimulus2.043e-072.45e-07Highly InformativeDirect
Biological Process (BP)regulation of calcium ion transport00Highly InformativeDirect
Biological Process (BP)protein localization to mitochondrion7.619e-085.928e-08Highly InformativeDirect
Biological Process (BP)cellular response to radiation1.368e-054.063e-05Highly InformativeDirect
Biological Process (BP)regulation of cellular response to stress2.138e-071.166e-09Highly InformativeDirect
Biological Process (BP)extrinsic apoptotic signaling pathway00Highly InformativeDirect
Biological Process (BP)intrinsic apoptotic signaling pathway00Highly InformativeDirect
Biological Process (BP)cell-type specific apoptotic process1.587e-111.036e-08Highly InformativeDirect
Biological Process (BP)regulation of ion homeostasis00Highly InformativeDirect
Biological Process (BP)positive regulation of apoptotic signaling pathway8.491e-133.135e-14Highly InformativeDirect
Biological Process (BP)regulation of intrinsic apoptotic signaling pathway0.00052931.034e-05Highly InformativeDirect
Biological Process (BP)pattern specification process8.617e-060.006027Highly InformativeInherited
Biological Process (BP)establishment of protein localization to organelle0.0014130.002344Highly InformativeInherited
Biological Process (BP)post-embryonic organ development1.411e-050.004335Highly InformativeInherited
Biological Process (BP)post-embryonic development3.811e-050.002932Highly InformativeInherited
Biological Process (BP)positive regulation of intracellular transport0.0081950.002787Highly InformativeInherited
Biological Process (BP)membrane fusion0.0027830.0002158Highly InformativeInherited
Biological Process (BP)cell division0.012030.06328Highly InformativeInherited
Molecular Function (MF)binding01.498e-12Least InformativeDirect
Molecular Function (MF)transporter activity8.608e-073.849e-06Moderately InformativeDirect
Molecular Function (MF)enzyme regulator activity0.026120.005408Moderately InformativeInherited
Molecular Function (MF)lipid binding2.309e-067.84e-07InformativeDirect
Molecular Function (MF)protein dimerization activity00InformativeDirect
Molecular Function (MF)peptidase regulator activity0.00036847.978e-05InformativeDirect
Molecular Function (MF)protein domain specific binding00Highly InformativeDirect
Molecular Function (MF)cysteine-type endopeptidase regulator activity involved in apoptotic process3.074e-073.237e-08Highly InformativeDirect
Molecular Function (MF)protein heterodimerization activity03.395e-11Highly InformativeDirect
Cellular Component (CC)membrane00Least InformativeDirect
Cellular Component (CC)cytoplasmic part2.465e-090Least InformativeDirect
Cellular Component (CC)intracellular organelle part5.611e-145.57e-08Least InformativeDirect
Cellular Component (CC)protein complex5.803e-060.003105Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.0082530.008818Least InformativeInherited
Cellular Component (CC)intracellular non-membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)endoplasmic reticulum2.32e-124.542e-11Moderately InformativeDirect
Cellular Component (CC)cytosol5.451e-061.678e-06Moderately InformativeDirect
Cellular Component (CC)endomembrane system3.069e-091.75e-07Moderately InformativeDirect
Cellular Component (CC)organelle membrane00Moderately InformativeDirect
Cellular Component (CC)intrinsic to membrane6.852e-072.557e-05Moderately InformativeDirect
Cellular Component (CC)organelle envelope00Moderately InformativeDirect
Cellular Component (CC)mitochondrial part00Moderately InformativeDirect
Cellular Component (CC)cytoskeleton0.20110.2481Moderately InformativeInherited
Cellular Component (CC)endoplasmic reticulum membrane4.926e-063.386e-06InformativeDirect
Cellular Component (CC)integral to membrane02.189e-13InformativeDirect
Cellular Component (CC)microtubule cytoskeleton0.0012940.03158InformativeInherited
Cellular Component (CC)centrosome2.142e-050.0001209Highly InformativeDirect
Cellular Component (CC)organelle outer membrane00Highly InformativeDirect
Cellular Component (CC)pore complex00Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 1.756e-05 Least Informative Direct
Biological Process (BP) developmental process 1.8e-05 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 0 Least Informative Direct
Biological Process (BP) response to stimulus 1.644e-13 Least Informative Direct
Biological Process (BP) localization 2.43e-05 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 2.098e-11 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.7351 Least Informative Inherited
Biological Process (BP) reproduction 1.944e-15 Moderately Informative Direct
Biological Process (BP) immune system process 1.187e-06 Moderately Informative Direct
Biological Process (BP) organelle organization 1.17e-09 Moderately Informative Direct
Biological Process (BP) signal transduction 6.946e-10 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 1.153e-05 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 9.285e-05 Moderately Informative Direct
Biological Process (BP) cell differentiation 3.024e-08 Moderately Informative Direct
Biological Process (BP) cellular response to stress 1.787e-10 Moderately Informative Direct
Biological Process (BP) regulation of programmed cell death 0 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 1.72e-05 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 0.0001441 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.0002018 Moderately Informative Direct
Biological Process (BP) multi-organism process 2.38e-05 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.03063 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.5019 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.9945 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.08532 Moderately Informative Inherited
Biological Process (BP) tissue development 0.6911 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.051 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.7338 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.5559 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.05979 Moderately Informative Inherited
Biological Process (BP) organ development 0.02629 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.002802 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.2632 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.03353 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.01558 Moderately Informative Inherited
Biological Process (BP) ion transport 0.01226 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.3832 Moderately Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 1.403e-06 Informative Direct
Biological Process (BP) developmental process involved in reproduction 1.352e-13 Informative Direct
Biological Process (BP) apoptotic process 0 Informative Direct
Biological Process (BP) mitochondrion organization 0 Informative Direct
Biological Process (BP) response to organic cyclic compound 2.411e-05 Informative Direct
Biological Process (BP) cellular membrane organization 0 Informative Direct
Biological Process (BP) cellular cation homeostasis 1.049e-12 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0.0004833 Informative Direct
Biological Process (BP) response to nutrient levels 9.391e-07 Informative Direct
Biological Process (BP) regulation of intracellular transport 5.27e-10 Informative Direct
Biological Process (BP) regulation of organelle organization 2.63e-05 Informative Direct
Biological Process (BP) tube development 0.0001971 Informative Direct
Biological Process (BP) intracellular signal transduction 2.155e-09 Informative Direct
Biological Process (BP) growth 0.000385 Informative Direct
Biological Process (BP) regulation of ion transport 1.467e-05 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.0001528 Informative Direct
Biological Process (BP) single organism reproductive process 3.299e-05 Informative Direct
Biological Process (BP) leukocyte activation 6.314e-07 Informative Direct
Biological Process (BP) hematopoietic or lymphoid organ development 4.14e-05 Informative Direct
Biological Process (BP) cellular process involved in reproduction 3.866e-09 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 7.41e-05 Informative Direct
Biological Process (BP) negative regulation of protein metabolic process 0.0002605 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.0001087 Informative Direct
Biological Process (BP) regulation of peptidase activity 0 Informative Direct
Biological Process (BP) metal ion homeostasis 7.233e-13 Informative Direct
Biological Process (BP) transmembrane transport 2.879e-07 Informative Direct
Biological Process (BP) epithelium development 1.705e-05 Informative Direct
Biological Process (BP) negative regulation of cell death 3.77e-15 Informative Direct
Biological Process (BP) reproductive system development 0 Informative Direct
Biological Process (BP) regulation of apoptotic signaling pathway 6.174e-11 Informative Direct
Biological Process (BP) positive regulation of signal transduction 0.02356 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.7659 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.604 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.8996 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.001441 Informative Inherited
Biological Process (BP) cardiovascular system development 0.05106 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.8255 Informative Inherited
Biological Process (BP) regulation of cell cycle process 1 Informative Inherited
Biological Process (BP) protein localization to organelle 0.02522 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.9887 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.009572 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.009247 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.1858 Informative Inherited
Biological Process (BP) response to other organism 0.05427 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.6621 Informative Inherited
Biological Process (BP) response to lipid 0.4755 Informative Inherited
Biological Process (BP) protein complex assembly 0.213 Informative Inherited
Biological Process (BP) response to wounding 0.8266 Informative Inherited
Biological Process (BP) sensory organ development 0.00535 Informative Inherited
Biological Process (BP) organ morphogenesis 0.1802 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.7485 Informative Inherited
Biological Process (BP) positive regulation of transport 0.1943 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.09644 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.1704 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.4064 Informative Inherited
Biological Process (BP) response to light stimulus 1 Informative Inherited
Biological Process (BP) response to DNA damage stimulus 0.06826 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.5238 Informative Inherited
Biological Process (BP) sexual reproduction 0.5628 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.2059 Informative Inherited
Biological Process (BP) cell cycle process 0.9537 Informative Inherited
Biological Process (BP) response to acid 2.438e-10 Highly Informative Direct
Biological Process (BP) angiogenesis 3.457e-05 Highly Informative Direct
Biological Process (BP) leukocyte homeostasis 0 Highly Informative Direct
Biological Process (BP) mitochondrial transport 0 Highly Informative Direct
Biological Process (BP) cellular calcium ion homeostasis 0 Highly Informative Direct
Biological Process (BP) mitochondrial membrane organization 8.982e-12 Highly Informative Direct
Biological Process (BP) spermatogenesis 1.328e-10 Highly Informative Direct
Biological Process (BP) gonad development 0 Highly Informative Direct
Biological Process (BP) response to UV 1.62e-10 Highly Informative Direct
Biological Process (BP) fertilization 8.307e-07 Highly Informative Direct
Biological Process (BP) response to virus 0.0002418 Highly Informative Direct
Biological Process (BP) response to toxic substance 0 Highly Informative Direct
Biological Process (BP) positive regulation of catabolic process 1.525e-05 Highly Informative Direct
Biological Process (BP) response to ionizing radiation 9.131e-14 Highly Informative Direct
Biological Process (BP) regulation of autophagy 2.833e-07 Highly Informative Direct
Biological Process (BP) positive regulation of organelle organization 2.217e-09 Highly Informative Direct
Biological Process (BP) regulation of mitochondrion organization 0 Highly Informative Direct
Biological Process (BP) positive regulation of endopeptidase activity 3.717e-05 Highly Informative Direct
Biological Process (BP) cellular process involved in reproduction in multicellular organism 1.168e-05 Highly Informative Direct
Biological Process (BP) ovulation cycle process 0 Highly Informative Direct
Biological Process (BP) negative regulation of protein modification process 0.0005073 Highly Informative Direct
Biological Process (BP) positive regulation of homeostatic process 6.445e-07 Highly Informative Direct
Biological Process (BP) ion transmembrane transport 3.194e-08 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 3.801e-14 Highly Informative Direct
Biological Process (BP) limb morphogenesis 3.328e-09 Highly Informative Direct
Biological Process (BP) modification of morphology or physiology of other organism 1.103e-05 Highly Informative Direct
Biological Process (BP) B cell activation 2.862e-05 Highly Informative Direct
Biological Process (BP) negative regulation of phosphorylation 0.0003133 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 2.125e-14 Highly Informative Direct
Biological Process (BP) positive regulation of programmed cell death 0.0002492 Highly Informative Direct
Biological Process (BP) regulation of protein complex assembly 2.861e-08 Highly Informative Direct
Biological Process (BP) positive regulation of ion transport 7.229e-05 Highly Informative Direct
Biological Process (BP) response to alkaloid 8.804e-09 Highly Informative Direct
Biological Process (BP) regulation of cysteine-type endopeptidase activity involved in apoptotic process 1.517e-11 Highly Informative Direct
Biological Process (BP) regulation of neuron apoptotic process 8.945e-05 Highly Informative Direct
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 5.733e-09 Highly Informative Direct
Biological Process (BP) multi-organism cellular process 8.941e-06 Highly Informative Direct
Biological Process (BP) development of primary female sexual characteristics 2.234e-06 Highly Informative Direct
Biological Process (BP) organelle fusion 0 Highly Informative Direct
Biological Process (BP) eye morphogenesis 5.013e-05 Highly Informative Direct
Biological Process (BP) response to axon injury 4.605e-10 Highly Informative Direct
Biological Process (BP) branching morphogenesis of an epithelial tube 1.141e-12 Highly Informative Direct
Biological Process (BP) regulation of binding 4.329e-06 Highly Informative Direct
Biological Process (BP) protein homooligomerization 8.068e-09 Highly Informative Direct
Biological Process (BP) response to glucocorticoid stimulus 2.45e-07 Highly Informative Direct
Biological Process (BP) regulation of calcium ion transport 0 Highly Informative Direct
Biological Process (BP) membrane fusion 0.0002158 Highly Informative Direct
Biological Process (BP) protein localization to mitochondrion 5.928e-08 Highly Informative Direct
Biological Process (BP) cellular response to radiation 4.063e-05 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 1.166e-09 Highly Informative Direct
Biological Process (BP) extrinsic apoptotic signaling pathway 0 Highly Informative Direct
Biological Process (BP) intrinsic apoptotic signaling pathway 0 Highly Informative Direct
Biological Process (BP) cell-type specific apoptotic process 1.036e-08 Highly Informative Direct
Biological Process (BP) regulation of ion homeostasis 0 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic signaling pathway 0.0001044 Highly Informative Direct
Biological Process (BP) positive regulation of apoptotic signaling pathway 3.135e-14 Highly Informative Direct
Biological Process (BP) regulation of intrinsic apoptotic signaling pathway 1.034e-05 Highly Informative Direct
Biological Process (BP) pattern specification process 0.006027 Highly Informative Inherited
Biological Process (BP) establishment of protein localization to organelle 0.002344 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.004335 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.002932 Highly Informative Inherited
Biological Process (BP) positive regulation of response to external stimulus 0.03329 Highly Informative Inherited
Biological Process (BP) regulation of response to nutrient levels 1 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.002787 Highly Informative Inherited
Biological Process (BP) cell division 0.06328 Highly Informative Inherited
Molecular Function (MF) binding 1.498e-12 Least Informative Direct
Molecular Function (MF) transporter activity 3.849e-06 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0.005408 Moderately Informative Inherited
Molecular Function (MF) lipid binding 7.84e-07 Informative Direct
Molecular Function (MF) protein dimerization activity 0 Informative Direct
Molecular Function (MF) peptidase regulator activity 7.978e-05 Informative Direct
Molecular Function (MF) protein domain specific binding 0 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 3.237e-08 Highly Informative Direct
Molecular Function (MF) protein heterodimerization activity 3.395e-11 Highly Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 5.57e-08 Least Informative Direct
Cellular Component (CC) protein complex 0.003105 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.008818 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 4.542e-11 Moderately Informative Direct
Cellular Component (CC) cytosol 1.678e-06 Moderately Informative Direct
Cellular Component (CC) endomembrane system 1.75e-07 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 2.557e-05 Moderately Informative Direct
Cellular Component (CC) organelle envelope 0 Moderately Informative Direct
Cellular Component (CC) mitochondrial part 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.2481 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 3.386e-06 Informative Direct
Cellular Component (CC) integral to membrane 2.189e-13 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.03158 Informative Inherited
Cellular Component (CC) centrosome 0.0001209 Highly Informative Direct
Cellular Component (CC) organelle outer membrane 0 Highly Informative Direct
Cellular Component (CC) pore complex 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.001042Least InformativeInherited
Disease Ontology (DO)immune system disease0.09284Least InformativeInherited
Disease Ontology (DO)nervous system disease0.489Least InformativeInherited
Disease Ontology (DO)hematologic cancer0.001456Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.00311Moderately InformativeInherited
Disease Ontology (DO)musculoskeletal system cancer0.009509Moderately InformativeInherited
Disease Ontology (DO)cell type cancer0.01147Moderately InformativeInherited
Disease Ontology (DO)endocrine system disease0.03366Moderately InformativeInherited
Disease Ontology (DO)bacterial infectious disease0.09546Moderately InformativeInherited
Disease Ontology (DO)connective tissue cancer0.0001522InformativeDirect
Disease Ontology (DO)thyroid gland disease0.0009145InformativeDirect
Disease Ontology (DO)primary bacterial infectious disease0.002699InformativeInherited
Disease Ontology (DO)chronic leukemia0.01921InformativeInherited
Disease Ontology (DO)lymphoblastic leukemia0.04341InformativeInherited
Disease Ontology (DO)viral infectious disease0.08981InformativeInherited
Disease Ontology (DO)chronic lymphocytic leukemia2.966e-06Highly InformativeDirect
Disease Ontology (DO)Graves' disease0.0001182Highly InformativeDirect
Disease Ontology (DO)tuberculosis0.0007906Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.01083Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.01656Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.07792Least InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.0008402Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal immune system organ morphology0.0009194Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal tumor incidence0.001286Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukopoiesis0.002916Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.004308Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lymphocyte morphology0.0101Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.02532Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell morphology0.06661Moderately InformativeInherited
Mammalian Phenotype (MP)renal/urinary system phenotype0.09221Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.173Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune cell physiology0.1833Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell-mediated immunity0.1884Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive immunity0.1996Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell physiology0.8291Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal metencephalon morphology8.438e-05InformativeDirect
Mammalian Phenotype (MP)abnormal mature B cell morphology0.0004357InformativeDirect
Mammalian Phenotype (MP)abnormal internal female genitalia morphology0.000618InformativeDirect
Mammalian Phenotype (MP)decreased germ cell number0.001027InformativeInherited
Mammalian Phenotype (MP)abnormal T cell morphology0.003027InformativeInherited
Mammalian Phenotype (MP)abnormal renal glomerulus morphology0.004319InformativeInherited
Mammalian Phenotype (MP)decreased leukocyte cell number0.004796InformativeInherited
Mammalian Phenotype (MP)abnormal lymphocyte cell number0.004967InformativeInherited
Mammalian Phenotype (MP)abnormal lymph node morphology0.2219InformativeInherited
Mammalian Phenotype (MP)abnormal sex gland morphology0.3007InformativeInherited
Mammalian Phenotype (MP)abnormal lymph organ size0.3733InformativeInherited
Mammalian Phenotype (MP)abnormal gametes0.5103InformativeInherited
Mammalian Phenotype (MP)abnormal immature B cell morphology6.635e-05Highly InformativeDirect
Mammalian Phenotype (MP)decreased mature B cell number0.0001538Highly InformativeDirect
Mammalian Phenotype (MP)abnormal autonomic nervous system morphology0.0005821Highly InformativeDirect
Mammalian Phenotype (MP)enlarged lymph nodes0.0008733Highly InformativeDirect
Mammalian Phenotype (MP)abnormal immune organ physiology0.007377Highly InformativeInherited

Document: MP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0Moderately InformativeDirect
Biological processHost-virus interaction3.447e-10Moderately InformativeDirect
Biological processDifferentiation0.0001673Moderately InformativeDirect
Biological processModulation of host cell apoptosis by virus0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus1.269e-07Least InformativeDirect
Cellular componentCytoplasm0.9418Least InformativeInherited
Cellular componentMitochondrion0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle7.959e-06Moderately InformativeDirect
Cellular componentCell junction1.64e-05Moderately InformativeDirect
Cellular componentEndoplasmic reticulum2.457e-05Moderately InformativeDirect
Cellular componentCytoskeleton0.000633Moderately InformativeDirect
Cellular componentMitochondrion outer membrane4.246e-08InformativeDirect
Cellular componentSynapse2.548e-07InformativeDirect
DomainTransmembrane0Least InformativeDirect
Post-translational modificationDevelopmental protein0.0005994Moderately InformativeDirect
Post-translational modificationPhosphoprotein1.427e-05Least InformativeDirect
Post-translational modificationUbl conjugation1.173e-10Moderately InformativeDirect
Post-translational modificationIsopeptide bond0.0009855Moderately InformativeDirect

Document: KW annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 13 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Bcl-2 inhibitors of programmed cell death domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 13 hidden Markov models representing the Bcl-2 inhibitors of programmed cell death superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]