SUPERFAMILY 1.75 HMM library and genome assignments server


Bcl-2 inhibitors of programmed cell death superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Toxins' membrane translocation domains [ 56836] (5)
Superfamily:   Bcl-2 inhibitors of programmed cell death [ 56854]
Families:   Bcl-2 inhibitors of programmed cell death [ 56855] (10)


Superfamily statistics
Genomes (135) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,144 0 29
Proteins 1,136 0 29


Functional annotation
General category Processes_IC
Detailed category Cell cycle, Apoptosis

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process2.136e-121.857e-05Least InformativeDirect
Biological Process (BP)developmental process1.548e-112.001e-05Least InformativeDirect
Biological Process (BP)single-organism cellular process00Least InformativeDirect
Biological Process (BP)regulation of cellular process00Least InformativeDirect
Biological Process (BP)response to stimulus02.604e-14Least InformativeDirect
Biological Process (BP)localization1.236e-083.574e-05Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis02.251e-11Least InformativeDirect
Biological Process (BP)regulation of metabolic process0.14420.7904Least InformativeInherited
Biological Process (BP)reproduction00Moderately InformativeDirect
Biological Process (BP)immune system process1.575e-107.201e-07Moderately InformativeDirect
Biological Process (BP)organelle organization3.3e-152.39e-09Moderately InformativeDirect
Biological Process (BP)signal transduction7.392e-113.497e-10Moderately InformativeDirect
Biological Process (BP)response to abiotic stimulus5.158e-061.151e-05Moderately InformativeDirect
Biological Process (BP)cell differentiation3.516e-141.04e-08Moderately InformativeDirect
Biological Process (BP)cellular response to stress3.889e-092.107e-10Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process2.335e-061.146e-05Moderately InformativeDirect
Biological Process (BP)regulation of catalytic activity3.184e-120Moderately InformativeDirect
Biological Process (BP)regulation of protein metabolic process1.131e-050.0001372Moderately InformativeDirect
Biological Process (BP)multi-organism process4.315e-081.374e-05Moderately InformativeDirect
Biological Process (BP)positive regulation of response to stimulus0.021040.0001335Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction3.297e-050.02999Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.56710.5093Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.96061Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.87420.9579Moderately InformativeInherited
Biological Process (BP)cellular localization0.0087240.07686Moderately InformativeInherited
Biological Process (BP)tissue development0.25960.7902Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.0051510.04336Moderately InformativeInherited
Biological Process (BP)response to organic substance0.55990.7053Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization0.95350.6839Moderately InformativeInherited
Biological Process (BP)cellular component biogenesis11Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.0039570.07837Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.00027730.151Moderately InformativeInherited
Biological Process (BP)organ development6.242e-060.01459Moderately InformativeInherited
Biological Process (BP)regulation of developmental process11Moderately InformativeInherited
Biological Process (BP)regulation of localization0.15640.2442Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.00097380.03022Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process7.911e-050.00198Moderately InformativeInherited
Biological Process (BP)ion transport0.0037780.01225Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process16.224e-05Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.94871Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function0.0014590.01815Moderately InformativeInherited
Biological Process (BP)homeostatic process0.70850.3825Moderately InformativeInherited
Biological Process (BP)regulation of protein phosphorylation3.757e-109.414e-07InformativeDirect
Biological Process (BP)developmental process involved in reproduction2.548e-124.075e-14InformativeDirect
Biological Process (BP)mitochondrion organization00InformativeDirect
Biological Process (BP)programmed cell death00InformativeDirect
Biological Process (BP)response to organic cyclic compound3.781e-062.539e-05InformativeDirect
Biological Process (BP)cellular membrane organization00InformativeDirect
Biological Process (BP)cellular cation homeostasis05.554e-13InformativeDirect
Biological Process (BP)response to nutrient levels0.00034176.233e-07InformativeDirect
Biological Process (BP)regulation of intracellular transport1.609e-094.589e-10InformativeDirect
Biological Process (BP)regulation of organelle organization1.749e-062.097e-05InformativeDirect
Biological Process (BP)tube development1.093e-050.0001574InformativeDirect
Biological Process (BP)intracellular signal transduction4.786e-082.285e-09InformativeDirect
Biological Process (BP)growth8.277e-080.0001023InformativeDirect
Biological Process (BP)regulation of apoptotic process00InformativeDirect
Biological Process (BP)regulation of ion transport4.214e-051.333e-05InformativeDirect
Biological Process (BP)regulation of cellular component biogenesis6.877e-060.0001353InformativeDirect
Biological Process (BP)single organism reproductive process3.529e-092.663e-05InformativeDirect
Biological Process (BP)leukocyte activation7.375e-086.232e-07InformativeDirect
Biological Process (BP)hematopoietic or lymphoid organ development3.791e-062.897e-05InformativeDirect
Biological Process (BP)cellular process involved in reproduction5.462e-113.096e-09InformativeDirect
Biological Process (BP)positive regulation of cellular component organization2.734e-067.382e-05InformativeDirect
Biological Process (BP)positive regulation of hydrolase activity1.177e-060.0001608InformativeDirect
Biological Process (BP)regulation of peptidase activity00InformativeDirect
Biological Process (BP)metal ion homeostasis03.883e-13InformativeDirect
Biological Process (BP)transmembrane transport1.466e-062.323e-07InformativeDirect
Biological Process (BP)epithelium development1.817e-095.475e-05InformativeDirect
Biological Process (BP)negative regulation of cell death2.3e-080InformativeDirect
Biological Process (BP)reproductive system development00InformativeDirect
Biological Process (BP)positive regulation of signal transduction0.0021430.0221InformativeInherited
Biological Process (BP)tissue morphogenesis9.359e-050.003731InformativeInherited
Biological Process (BP)cardiovascular system development0.036940.05233InformativeInherited
Biological Process (BP)regulation of mitotic cell cycle0.69160.8085InformativeInherited
Biological Process (BP)regulation of cell cycle process0.95521InformativeInherited
Biological Process (BP)regulation of response to stress0.016320.001049InformativeInherited
Biological Process (BP)protein localization to organelle0.027860.02681InformativeInherited
Biological Process (BP)cellular response to endogenous stimulus0.82611InformativeInherited
Biological Process (BP)response to organonitrogen compound0.0039770.01024InformativeInherited
Biological Process (BP)cellular response to nitrogen compound0.0026480.009256InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound0.24750.1867InformativeInherited
Biological Process (BP)response to other organism0.041290.05407InformativeInherited
Biological Process (BP)response to hormone stimulus0.63330.637InformativeInherited
Biological Process (BP)response to lipid0.55440.4815InformativeInherited
Biological Process (BP)protein complex assembly0.29280.09867InformativeInherited
Biological Process (BP)response to wounding0.56170.8281InformativeInherited
Biological Process (BP)sensory organ development6.676e-050.00434InformativeInherited
Biological Process (BP)organ morphogenesis0.0030010.1588InformativeInherited
Biological Process (BP)positive regulation of developmental process0.57180.7625InformativeInherited
Biological Process (BP)positive regulation of transport0.20890.1912InformativeInherited
Biological Process (BP)embryo development ending in birth or egg hatching0.080270.04818InformativeInherited
Biological Process (BP)negative regulation of protein metabolic process0.0054340.0002572InformativeInherited
Biological Process (BP)cellular component morphogenesis0.0030230.1532InformativeInherited
Biological Process (BP)regulation of cellular catabolic process0.34430.000469InformativeInherited
Biological Process (BP)response to light stimulus11InformativeInherited
Biological Process (BP)response to DNA damage stimulus0.039450.06805InformativeInherited
Biological Process (BP)multicellular organismal reproductive process0.061750.5276InformativeInherited
Biological Process (BP)sexual reproduction0.10310.5619InformativeInherited
Biological Process (BP)anatomical structure formation involved in morphogenesis0.017680.1765InformativeInherited
Biological Process (BP)cell cycle process0.5110.949InformativeInherited
Biological Process (BP)response to acid2.028e-092.469e-10Highly InformativeDirect
Biological Process (BP)angiogenesis6.419e-052.958e-05Highly InformativeDirect
Biological Process (BP)leukocyte homeostasis00Highly InformativeDirect
Biological Process (BP)mitochondrial transport00Highly InformativeDirect
Biological Process (BP)cellular calcium ion homeostasis00Highly InformativeDirect
Biological Process (BP)cellular membrane fusion3.284e-058.292e-08Highly InformativeDirect
Biological Process (BP)mitochondrial membrane organization8.946e-099.275e-12Highly InformativeDirect
Biological Process (BP)spermatogenesis3.3e-158.053e-11Highly InformativeDirect
Biological Process (BP)gonad development00Highly InformativeDirect
Biological Process (BP)response to UV9.298e-131.126e-10Highly InformativeDirect
Biological Process (BP)fertilization9.37e-068.276e-07Highly InformativeDirect
Biological Process (BP)response to virus0.00016240.0002676Highly InformativeDirect
Biological Process (BP)response to toxic substance00Highly InformativeDirect
Biological Process (BP)response to ionizing radiation5.204e-137.918e-14Highly InformativeDirect
Biological Process (BP)regulation of autophagy2.099e-052.752e-07Highly InformativeDirect
Biological Process (BP)positive regulation of organelle organization9.669e-102.145e-09Highly InformativeDirect
Biological Process (BP)regulation of mitochondrion organization00Highly InformativeDirect
Biological Process (BP)positive regulation of peptidase activity03.722e-15Highly InformativeDirect
Biological Process (BP)cellular process involved in reproduction in multicellular organism3.779e-051.099e-05Highly InformativeDirect
Biological Process (BP)ovulation cycle process00Highly InformativeDirect
Biological Process (BP)negative regulation of protein modification process0.00076960.0004835Highly InformativeDirect
Biological Process (BP)positive regulation of homeostatic process3.01e-065.037e-07Highly InformativeDirect
Biological Process (BP)ion transmembrane transport6.454e-112.711e-08Highly InformativeDirect
Biological Process (BP)response to endoplasmic reticulum stress03.75e-14Highly InformativeDirect
Biological Process (BP)limb morphogenesis3.655e-142.411e-09Highly InformativeDirect
Biological Process (BP)modification of morphology or physiology of other organism2.048e-061.075e-05Highly InformativeDirect
Biological Process (BP)B cell activation8.133e-052.741e-05Highly InformativeDirect
Biological Process (BP)negative regulation of phosphorylation0.00048930.0002919Highly InformativeDirect
Biological Process (BP)regulation of membrane potential02.099e-14Highly InformativeDirect
Biological Process (BP)positive regulation of programmed cell death3.25e-070.0001604Highly InformativeDirect
Biological Process (BP)regulation of protein complex assembly8.363e-072.732e-08Highly InformativeDirect
Biological Process (BP)positive regulation of ion transport0.00019546.683e-05Highly InformativeDirect
Biological Process (BP)response to alkaloid1.686e-096.882e-09Highly InformativeDirect
Biological Process (BP)regulation of neuron apoptotic process0.00073950.0001588Highly InformativeDirect
Biological Process (BP)symbiosis, encompassing mutualism through parasitism4.157e-122.441e-09Highly InformativeDirect
Biological Process (BP)multi-organism cellular process3.72e-078.248e-06Highly InformativeDirect
Biological Process (BP)development of primary female sexual characteristics0.00033962.57e-06Highly InformativeDirect
Biological Process (BP)organelle fusion3.3e-150Highly InformativeDirect
Biological Process (BP)eye morphogenesis1.896e-055.093e-05Highly InformativeDirect
Biological Process (BP)response to axon injury5.04e-103.46e-10Highly InformativeDirect
Biological Process (BP)branching morphogenesis of an epithelial tube07.459e-13Highly InformativeDirect
Biological Process (BP)regulation of binding5.262e-082.444e-06Highly InformativeDirect
Biological Process (BP)protein homooligomerization2.929e-095.586e-09Highly InformativeDirect
Biological Process (BP)regulation of calcium ion transport00Highly InformativeDirect
Biological Process (BP)protein localization to mitochondrion6.27e-084.681e-08Highly InformativeDirect
Biological Process (BP)cellular response to radiation1.533e-054.151e-05Highly InformativeDirect
Biological Process (BP)regulation of cellular response to stress1.948e-077.918e-10Highly InformativeDirect
Biological Process (BP)extrinsic apoptotic signaling pathway00Highly InformativeDirect
Biological Process (BP)intrinsic apoptotic signaling pathway00Highly InformativeDirect
Biological Process (BP)cell-type specific apoptotic process1.522e-117.677e-09Highly InformativeDirect
Biological Process (BP)regulation of ion homeostasis00Highly InformativeDirect
Biological Process (BP)regulation of cysteine-type endopeptidase activity00Highly InformativeDirect
Biological Process (BP)positive regulation of apoptotic signaling pathway8.878e-133.591e-14Highly InformativeDirect
Biological Process (BP)regulation of intrinsic apoptotic signaling pathway0.00058637.069e-06Highly InformativeDirect
Biological Process (BP)pattern specification process6.041e-060.005102Highly InformativeInherited
Biological Process (BP)establishment of protein localization to organelle0.0014590.002359Highly InformativeInherited
Biological Process (BP)response to corticosteroid stimulus0.056140.01121Highly InformativeInherited
Biological Process (BP)post-embryonic organ development8.736e-060.003725Highly InformativeInherited
Biological Process (BP)post-embryonic development2.23e-050.002156Highly InformativeInherited
Biological Process (BP)positive regulation of intracellular transport0.0084880.002544Highly InformativeInherited
Biological Process (BP)cell division0.010480.05938Highly InformativeInherited
Molecular Function (MF)binding05.962e-13Least InformativeDirect
Molecular Function (MF)transporter activity5.561e-072.564e-06Moderately InformativeDirect
Molecular Function (MF)enzyme regulator activity0.02240.004495Moderately InformativeInherited
Molecular Function (MF)lipid binding1.905e-066.79e-07InformativeDirect
Molecular Function (MF)protein dimerization activity00InformativeDirect
Molecular Function (MF)peptidase regulator activity0.00030697.951e-05InformativeDirect
Molecular Function (MF)protein domain specific binding00Highly InformativeDirect
Molecular Function (MF)cysteine-type endopeptidase regulator activity involved in apoptotic process2.61e-073.292e-08Highly InformativeDirect
Molecular Function (MF)protein heterodimerization activity03.625e-11Highly InformativeDirect
Cellular Component (CC)membrane00Least InformativeDirect
Cellular Component (CC)cytoplasmic part2.961e-090Least InformativeDirect
Cellular Component (CC)intracellular organelle part1.954e-143.302e-08Least InformativeDirect
Cellular Component (CC)protein complex3.326e-060.001919Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.011070.01186Least InformativeInherited
Cellular Component (CC)intracellular non-membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)endoplasmic reticulum1.205e-123.176e-11Moderately InformativeDirect
Cellular Component (CC)cytosol2.129e-066.491e-07Moderately InformativeDirect
Cellular Component (CC)endomembrane system2.909e-091.648e-07Moderately InformativeDirect
Cellular Component (CC)organelle membrane00Moderately InformativeDirect
Cellular Component (CC)intrinsic to membrane6.823e-072.501e-05Moderately InformativeDirect
Cellular Component (CC)organelle envelope00Moderately InformativeDirect
Cellular Component (CC)mitochondrial part00Moderately InformativeDirect
Cellular Component (CC)cytoskeleton0.19950.2192Moderately InformativeInherited
Cellular Component (CC)endoplasmic reticulum membrane3.737e-063.23e-06InformativeDirect
Cellular Component (CC)integral to membrane07.862e-14InformativeDirect
Cellular Component (CC)microtubule cytoskeleton0.0010810.02709InformativeInherited
Cellular Component (CC)centrosome2.034e-059.817e-05Highly InformativeDirect
Cellular Component (CC)organelle outer membrane00Highly InformativeDirect
Cellular Component (CC)pore complex00Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 1.857e-05 Least Informative Direct
Biological Process (BP) developmental process 2.001e-05 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 0 Least Informative Direct
Biological Process (BP) response to stimulus 2.604e-14 Least Informative Direct
Biological Process (BP) localization 3.574e-05 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 2.251e-11 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.7904 Least Informative Inherited
Biological Process (BP) reproduction 0 Moderately Informative Direct
Biological Process (BP) immune system process 7.201e-07 Moderately Informative Direct
Biological Process (BP) organelle organization 2.39e-09 Moderately Informative Direct
Biological Process (BP) signal transduction 3.497e-10 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 1.151e-05 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 6.224e-05 Moderately Informative Direct
Biological Process (BP) cell differentiation 1.04e-08 Moderately Informative Direct
Biological Process (BP) cellular response to stress 2.107e-10 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 1.146e-05 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 0.0001335 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.0001372 Moderately Informative Direct
Biological Process (BP) multi-organism process 1.374e-05 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.02999 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.5093 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.9579 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.07686 Moderately Informative Inherited
Biological Process (BP) tissue development 0.7902 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.04336 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.7053 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.6839 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.07837 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.151 Moderately Informative Inherited
Biological Process (BP) organ development 0.01459 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.00198 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.2442 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.03022 Moderately Informative Inherited
Biological Process (BP) ion transport 0.01225 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.01815 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.3825 Moderately Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 9.414e-07 Informative Direct
Biological Process (BP) developmental process involved in reproduction 4.075e-14 Informative Direct
Biological Process (BP) mitochondrion organization 0 Informative Direct
Biological Process (BP) programmed cell death 0 Informative Direct
Biological Process (BP) response to organic cyclic compound 2.539e-05 Informative Direct
Biological Process (BP) cellular membrane organization 0 Informative Direct
Biological Process (BP) cellular cation homeostasis 5.554e-13 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0.000469 Informative Direct
Biological Process (BP) response to nutrient levels 6.233e-07 Informative Direct
Biological Process (BP) regulation of intracellular transport 4.589e-10 Informative Direct
Biological Process (BP) regulation of organelle organization 2.097e-05 Informative Direct
Biological Process (BP) tube development 0.0001574 Informative Direct
Biological Process (BP) intracellular signal transduction 2.285e-09 Informative Direct
Biological Process (BP) growth 0.0001023 Informative Direct
Biological Process (BP) regulation of apoptotic process 0 Informative Direct
Biological Process (BP) regulation of ion transport 1.333e-05 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.0001353 Informative Direct
Biological Process (BP) single organism reproductive process 2.663e-05 Informative Direct
Biological Process (BP) leukocyte activation 6.232e-07 Informative Direct
Biological Process (BP) hematopoietic or lymphoid organ development 2.897e-05 Informative Direct
Biological Process (BP) cellular process involved in reproduction 3.096e-09 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 7.382e-05 Informative Direct
Biological Process (BP) negative regulation of protein metabolic process 0.0002572 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.0001608 Informative Direct
Biological Process (BP) regulation of peptidase activity 0 Informative Direct
Biological Process (BP) metal ion homeostasis 3.883e-13 Informative Direct
Biological Process (BP) transmembrane transport 2.323e-07 Informative Direct
Biological Process (BP) epithelium development 5.475e-05 Informative Direct
Biological Process (BP) negative regulation of cell death 0 Informative Direct
Biological Process (BP) reproductive system development 0 Informative Direct
Biological Process (BP) positive regulation of signal transduction 0.0221 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.75 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.5897 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.891 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.003731 Informative Inherited
Biological Process (BP) cardiovascular system development 0.05233 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.8085 Informative Inherited
Biological Process (BP) regulation of cell cycle process 1 Informative Inherited
Biological Process (BP) regulation of response to stress 0.001049 Informative Inherited
Biological Process (BP) protein localization to organelle 0.02681 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 1 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.01024 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.009256 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.1867 Informative Inherited
Biological Process (BP) response to other organism 0.05407 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.637 Informative Inherited
Biological Process (BP) response to lipid 0.4815 Informative Inherited
Biological Process (BP) protein complex assembly 0.09867 Informative Inherited
Biological Process (BP) response to wounding 0.8281 Informative Inherited
Biological Process (BP) sensory organ development 0.00434 Informative Inherited
Biological Process (BP) organ morphogenesis 0.1588 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.7625 Informative Inherited
Biological Process (BP) positive regulation of transport 0.1912 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.04818 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.1532 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.4109 Informative Inherited
Biological Process (BP) response to light stimulus 1 Informative Inherited
Biological Process (BP) response to DNA damage stimulus 0.06805 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.5276 Informative Inherited
Biological Process (BP) sexual reproduction 0.5619 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.1765 Informative Inherited
Biological Process (BP) cell cycle process 0.949 Informative Inherited
Biological Process (BP) response to acid 2.469e-10 Highly Informative Direct
Biological Process (BP) angiogenesis 2.958e-05 Highly Informative Direct
Biological Process (BP) leukocyte homeostasis 0 Highly Informative Direct
Biological Process (BP) mitochondrial transport 0 Highly Informative Direct
Biological Process (BP) cellular calcium ion homeostasis 0 Highly Informative Direct
Biological Process (BP) cellular membrane fusion 8.292e-08 Highly Informative Direct
Biological Process (BP) mitochondrial membrane organization 9.275e-12 Highly Informative Direct
Biological Process (BP) spermatogenesis 8.053e-11 Highly Informative Direct
Biological Process (BP) gonad development 0 Highly Informative Direct
Biological Process (BP) response to UV 1.126e-10 Highly Informative Direct
Biological Process (BP) fertilization 8.276e-07 Highly Informative Direct
Biological Process (BP) response to virus 0.0002676 Highly Informative Direct
Biological Process (BP) response to toxic substance 0 Highly Informative Direct
Biological Process (BP) positive regulation of catabolic process 1.399e-05 Highly Informative Direct
Biological Process (BP) response to ionizing radiation 7.918e-14 Highly Informative Direct
Biological Process (BP) regulation of autophagy 2.752e-07 Highly Informative Direct
Biological Process (BP) positive regulation of organelle organization 2.145e-09 Highly Informative Direct
Biological Process (BP) regulation of mitochondrion organization 0 Highly Informative Direct
Biological Process (BP) positive regulation of peptidase activity 3.722e-15 Highly Informative Direct
Biological Process (BP) cellular process involved in reproduction in multicellular organism 1.099e-05 Highly Informative Direct
Biological Process (BP) ovulation cycle process 0 Highly Informative Direct
Biological Process (BP) negative regulation of protein modification process 0.0004835 Highly Informative Direct
Biological Process (BP) positive regulation of homeostatic process 5.037e-07 Highly Informative Direct
Biological Process (BP) ion transmembrane transport 2.711e-08 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 3.75e-14 Highly Informative Direct
Biological Process (BP) limb morphogenesis 2.411e-09 Highly Informative Direct
Biological Process (BP) modification of morphology or physiology of other organism 1.075e-05 Highly Informative Direct
Biological Process (BP) B cell activation 2.741e-05 Highly Informative Direct
Biological Process (BP) negative regulation of phosphorylation 0.0002919 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 2.099e-14 Highly Informative Direct
Biological Process (BP) positive regulation of programmed cell death 0.0001604 Highly Informative Direct
Biological Process (BP) regulation of protein complex assembly 2.732e-08 Highly Informative Direct
Biological Process (BP) positive regulation of ion transport 6.683e-05 Highly Informative Direct
Biological Process (BP) response to alkaloid 6.882e-09 Highly Informative Direct
Biological Process (BP) regulation of neuron apoptotic process 0.0001588 Highly Informative Direct
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 2.441e-09 Highly Informative Direct
Biological Process (BP) multi-organism cellular process 8.248e-06 Highly Informative Direct
Biological Process (BP) development of primary female sexual characteristics 2.57e-06 Highly Informative Direct
Biological Process (BP) organelle fusion 0 Highly Informative Direct
Biological Process (BP) eye morphogenesis 5.093e-05 Highly Informative Direct
Biological Process (BP) response to axon injury 3.46e-10 Highly Informative Direct
Biological Process (BP) branching morphogenesis of an epithelial tube 7.459e-13 Highly Informative Direct
Biological Process (BP) regulation of binding 2.444e-06 Highly Informative Direct
Biological Process (BP) protein homooligomerization 5.586e-09 Highly Informative Direct
Biological Process (BP) regulation of calcium ion transport 0 Highly Informative Direct
Biological Process (BP) protein localization to mitochondrion 4.681e-08 Highly Informative Direct
Biological Process (BP) cellular response to radiation 4.151e-05 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 7.918e-10 Highly Informative Direct
Biological Process (BP) extrinsic apoptotic signaling pathway 0 Highly Informative Direct
Biological Process (BP) intrinsic apoptotic signaling pathway 0 Highly Informative Direct
Biological Process (BP) cell-type specific apoptotic process 7.677e-09 Highly Informative Direct
Biological Process (BP) regulation of ion homeostasis 0 Highly Informative Direct
Biological Process (BP) regulation of cysteine-type endopeptidase activity 0 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic signaling pathway 0.0001043 Highly Informative Direct
Biological Process (BP) positive regulation of apoptotic signaling pathway 3.591e-14 Highly Informative Direct
Biological Process (BP) regulation of intrinsic apoptotic signaling pathway 7.069e-06 Highly Informative Direct
Biological Process (BP) pattern specification process 0.005102 Highly Informative Inherited
Biological Process (BP) establishment of protein localization to organelle 0.002359 Highly Informative Inherited
Biological Process (BP) response to corticosteroid stimulus 0.01121 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.003725 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.002156 Highly Informative Inherited
Biological Process (BP) positive regulation of response to external stimulus 0.03448 Highly Informative Inherited
Biological Process (BP) regulation of response to nutrient levels 1 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.002544 Highly Informative Inherited
Biological Process (BP) cell division 0.05938 Highly Informative Inherited
Molecular Function (MF) binding 5.962e-13 Least Informative Direct
Molecular Function (MF) transporter activity 2.564e-06 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0.004495 Moderately Informative Inherited
Molecular Function (MF) lipid binding 6.79e-07 Informative Direct
Molecular Function (MF) protein dimerization activity 0 Informative Direct
Molecular Function (MF) peptidase regulator activity 7.951e-05 Informative Direct
Molecular Function (MF) protein domain specific binding 0 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 3.292e-08 Highly Informative Direct
Molecular Function (MF) protein heterodimerization activity 3.625e-11 Highly Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 3.302e-08 Least Informative Direct
Cellular Component (CC) protein complex 0.001919 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.01186 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 3.176e-11 Moderately Informative Direct
Cellular Component (CC) cytosol 6.491e-07 Moderately Informative Direct
Cellular Component (CC) endomembrane system 1.648e-07 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 2.501e-05 Moderately Informative Direct
Cellular Component (CC) organelle envelope 0 Moderately Informative Direct
Cellular Component (CC) mitochondrial part 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.2192 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 3.23e-06 Informative Direct
Cellular Component (CC) integral to membrane 7.862e-14 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.02709 Informative Inherited
Cellular Component (CC) centrosome 9.817e-05 Highly Informative Direct
Cellular Component (CC) organelle outer membrane 0 Highly Informative Direct
Cellular Component (CC) pore complex 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.001026Least InformativeInherited
Disease Ontology (DO)immune system disease0.08598Least InformativeInherited
Disease Ontology (DO)nervous system disease0.5695Least InformativeInherited
Disease Ontology (DO)hematologic cancer0.001439Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.003154Moderately InformativeInherited
Disease Ontology (DO)cell type cancer0.01145Moderately InformativeInherited
Disease Ontology (DO)endocrine system disease0.03147Moderately InformativeInherited
Disease Ontology (DO)bacterial infectious disease0.09812Moderately InformativeInherited
Disease Ontology (DO)connective tissue cancer0.0001474InformativeDirect
Disease Ontology (DO)thyroid gland disease0.0008997InformativeDirect
Disease Ontology (DO)primary bacterial infectious disease0.002845InformativeInherited
Disease Ontology (DO)chronic leukemia0.01953InformativeInherited
Disease Ontology (DO)lymphoblastic leukemia0.04485InformativeInherited
Disease Ontology (DO)viral infectious disease0.08752InformativeInherited
Disease Ontology (DO)chronic lymphocytic leukemia3.327e-06Highly InformativeDirect
Disease Ontology (DO)Graves' disease0.000116Highly InformativeDirect
Disease Ontology (DO)tuberculosis0.0008762Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.01412Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.02245Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.2006Least InformativeInherited
Mammalian Phenotype (MP)abnormal leukopoiesis0.009128Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.01684Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lymphocyte morphology0.02749Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.06302Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell morphology0.06633Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal metencephalon morphology0.0003293InformativeDirect
Mammalian Phenotype (MP)abnormal mature B cell morphology0.00113InformativeInherited
Mammalian Phenotype (MP)decreased leukocyte cell number0.01405InformativeInherited
Mammalian Phenotype (MP)abnormal lymphocyte cell number0.01432InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.07016InformativeInherited
Mammalian Phenotype (MP)abnormal immature B cell morphology0.0001931Highly InformativeDirect
Mammalian Phenotype (MP)decreased mature B cell number0.0004229Highly InformativeDirect
Mammalian Phenotype (MP)abnormal autonomic nervous system morphology0.0005858Highly InformativeDirect
Mammalian Phenotype (MP)abnormal immune organ physiology0.01302Highly InformativeInherited

Document: MP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0Moderately InformativeDirect
Biological processHost-virus interaction3.464e-10Moderately InformativeDirect
Biological processDifferentiation0.0001679Moderately InformativeDirect
Biological processModulation of host cell apoptosis by virus0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus1.291e-07Least InformativeDirect
Cellular componentCytoplasm0.9431Least InformativeInherited
Cellular componentMitochondrion0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle8.003e-06Moderately InformativeDirect
Cellular componentCell junction1.649e-05Moderately InformativeDirect
Cellular componentEndoplasmic reticulum2.474e-05Moderately InformativeDirect
Cellular componentCytoskeleton0.0006338Moderately InformativeDirect
Cellular componentMitochondrion outer membrane4.251e-08InformativeDirect
Cellular componentSynapse2.571e-07InformativeDirect
DomainTransmembrane0Least InformativeDirect
Post-translational modificationDevelopmental protein0.0006041Moderately InformativeDirect
Post-translational modificationPhosphoprotein1.452e-05Least InformativeDirect
Post-translational modificationUbl conjugation1.045e-10Moderately InformativeDirect
Post-translational modificationIsopeptide bond0.0008931Moderately InformativeDirect

Document: KW annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 13 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Bcl-2 inhibitors of programmed cell death domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 13 hidden Markov models representing the Bcl-2 inhibitors of programmed cell death superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]