SUPERFAMILY 1.75 HMM library and genome assignments server

HAD-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   HAD-like [ 56783]
Superfamily:   HAD-like [ 56784] (25)
Families:   Probable phosphatase YrbI [ 69467]
  HAD-related [ 56785] (2)
  beta-Phosphoglucomutase-like [ 75173] (9)
  YihX-like [ 56789] (2)
  Phosphonoacetaldehyde hydrolase-like [ 56792] (2)
  Phosphoserine phosphatase [ 64511]
  5'(3')-deoxyribonucleotidase (dNT-2) [ 82382]
  Homoserine kinase ThrH [ 102304]
  Class B acid phosphatase, AphA [ 102307]
  Hypothetical protein MW1667 (SA1546) [ 102310]
  phosphatase domain of polynucleotide kinase [ 82385] (2)
  Predicted hydrolases Cof [ 82388] (11)
  NagD-like [ 102317] (6)
  Meta-cation ATPase, catalytic domain P [ 81656] (2)
  Trehalose-phosphatase [ 110506]
  NLI interacting factor-like phosphatase [ 110509]
  Magnesium-dependent phosphatase-1, Mdp1 [ 117509]
  Hypothetical protein VC0232 [ 117512]
  Histidinol phosphatase-like [ 142177] (3)
  MtnX-like [ 142180]
  Pyrimidine 5'-nucleotidase (UMPH-1) [ 142183]
  Enolase-phosphatase E1 [ 142186] (2)
  5' nucleotidase-like [ 142191]
  AF1437-like [ 159537]
  BT0820-like [ 159540]


Superfamily statistics
Genomes (3,234) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 90,519 405,420 77
Proteins 89,981 404,734 77


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)positive regulation of biological process11Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis11Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)regulation of metabolic process11Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)heterocycle metabolic process11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process11Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)protein metabolic process0.70721Least InformativeInherited
Biological Process (BP)carbohydrate metabolic process0.000049230.0003866Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)sulfur compound metabolic process0.86141Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process0.7240.6025Moderately InformativeInherited
Biological Process (BP)cellular catabolic process11Moderately InformativeInherited
Biological Process (BP)cofactor metabolic process11Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.82041Moderately InformativeInherited
Biological Process (BP)small molecule biosynthetic process0.0055180.2316Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.95851Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.51691Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.036280.001448Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process0.027070.000007779Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process0.9260.01969Moderately InformativeInherited
Biological Process (BP)single-organism catabolic process0.85250.3028Moderately InformativeInherited
Biological Process (BP)nucleobase-containing small molecule metabolic process0.17310.002861Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process11Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process0.57091Moderately InformativeInherited
Biological Process (BP)lipid metabolic process0.75030.008099Moderately InformativeInherited
Biological Process (BP)cellular amino acid metabolic process0.084890.2756Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.00089880.4177Moderately InformativeInherited
Biological Process (BP)carbohydrate biosynthetic process0.0000014190.0000000002076InformativeDirect
Biological Process (BP)dephosphorylation00InformativeDirect
Biological Process (BP)regulation of lipid metabolic process0.00000027360.000000524InformativeDirect
Biological Process (BP)cellular metabolic compound salvage0.00029870.00001853InformativeDirect
Biological Process (BP)single-organism membrane organization0.00032610InformativeDirect
Biological Process (BP)regulation of mitotic cell cycle0.0008850.5384InformativeInherited
Biological Process (BP)regulation of cell cycle process0.0016270.8366InformativeInherited
Biological Process (BP)sulfur compound biosynthetic process0.012940.06448InformativeInherited
Biological Process (BP)aspartate family amino acid metabolic process0.0028420.1135InformativeInherited
Biological Process (BP)alpha-amino acid biosynthetic process0.0076560.01292InformativeInherited
Biological Process (BP)positive regulation of cellular biosynthetic process0.013381InformativeInherited
Biological Process (BP)nucleobase-containing compound catabolic process0.36250.008104InformativeInherited
Biological Process (BP)organophosphate catabolic process0.0015610.000002058InformativeInherited
Biological Process (BP)carbohydrate derivative catabolic process0.26860.0001976InformativeInherited
Biological Process (BP)liposaccharide metabolic process0.0043830.012InformativeInherited
Biological Process (BP)cellular carbohydrate metabolic process0.0011590.00005839InformativeInherited
Biological Process (BP)polysaccharide metabolic process0.029410.1864InformativeInherited
Biological Process (BP)sulfur amino acid metabolic process0.00085260.01127InformativeInherited
Biological Process (BP)protein dephosphorylation0.00089890.00000000005684Highly InformativeDirect
Biological Process (BP)nucleus organization0.000000000012370.00000001976Highly InformativeDirect
Biological Process (BP)lipopolysaccharide metabolic process0.000018870.0001426Highly InformativeDirect
Biological Process (BP)amino acid salvage0.000000034110.00000001794Highly InformativeDirect
Biological Process (BP)positive regulation of lipid metabolic process0.000000000051770.00001723Highly InformativeDirect
Biological Process (BP)L-methionine biosynthetic process0.000000027130.000000008616Highly InformativeDirect
Biological Process (BP)negative regulation of mitotic cell cycle phase transition0.0023180.1693Highly InformativeInherited
Biological Process (BP)regulation of G1/S transition of mitotic cell cycle0.00018080.00345Highly InformativeInherited
Biological Process (BP)deoxyribonucleotide metabolic process0.0021190.02559Highly InformativeInherited
Biological Process (BP)cellular polysaccharide biosynthetic process0.0009260.004315Highly InformativeInherited
Biological Process (BP)serine family amino acid metabolic process0.0022970.0004991Highly InformativeInherited
Molecular Function (MF)hydrolase activity00Least InformativeDirect
Molecular Function (MF)binding0.000022340.8775Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds00Moderately InformativeDirect
Molecular Function (MF)cation binding00Moderately InformativeDirect
Molecular Function (MF)isomerase activity0.056111Moderately InformativeInherited
Molecular Function (MF)magnesium ion binding00InformativeDirect
Molecular Function (MF)phosphatase activity00InformativeDirect
Molecular Function (MF)intramolecular transferase activity0.00000000023390.000002233Highly InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle10.02323Least InformativeInherited
Cellular Component (CC)intracellular organelle part10.5617Least InformativeInherited
Cellular Component (CC)cytoplasmic part10.0000000003161Least InformativeInherited
Cellular Component (CC)protein complex11Least InformativeInherited
Cellular Component (CC)membrane10Least InformativeInherited
Cellular Component (CC)organelle envelope0.072850.001485Moderately InformativeInherited
Cellular Component (CC)nuclear part0.37551Moderately InformativeInherited
Cellular Component (CC)membrane region0.01690.000001077Moderately InformativeInherited
Cellular Component (CC)endoplasmic reticulum0.038850Moderately InformativeInherited
Cellular Component (CC)bounding membrane of organelle0.056390.001386Moderately InformativeInherited
Cellular Component (CC)endoplasmic reticulum membrane0.000024490.000000005842InformativeDirect
Cellular Component (CC)nuclear envelope0.0000020750.002606InformativeInherited
Cellular Component (CC)protein serine/threonine phosphatase complex0.00000000000055840.00000002764Highly InformativeDirect
Cellular Component (CC)nuclear membrane0.000000000079710.0000003292Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) positive regulation of biological process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.0003866 Moderately Informative Direct
Biological Process (BP) ion transport 0 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.000007779 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.9088 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.6025 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cofactor metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) single-organism organelle organization 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.2316 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.001672 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.829 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.01969 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.001448 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.008099 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.02842 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.2756 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.4177 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.002861 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.3028 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.7836 Moderately Informative Inherited
Biological Process (BP) mitochondrion organization 0.00009927 Informative Direct
Biological Process (BP) blood circulation 0.0001479 Informative Direct
Biological Process (BP) lipid localization 0.00000000000002753 Informative Direct
Biological Process (BP) carbohydrate biosynthetic process 0.0000000002076 Informative Direct
Biological Process (BP) dephosphorylation 0 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 0.000000524 Informative Direct
Biological Process (BP) metal ion transport 0.00000001696 Informative Direct
Biological Process (BP) ion transmembrane transport 0 Informative Direct
Biological Process (BP) cellular metabolic compound salvage 0.00001853 Informative Direct
Biological Process (BP) regulation of ion transport 0.0000007346 Informative Direct
Biological Process (BP) regulation of system process 0.000000000001824 Informative Direct
Biological Process (BP) cellular carbohydrate metabolic process 0.00005839 Informative Direct
Biological Process (BP) single-organism membrane organization 0 Informative Direct
Biological Process (BP) organophosphate catabolic process 0.000002058 Informative Direct
Biological Process (BP) cation homeostasis 0.0003772 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0.0001976 Informative Direct
Biological Process (BP) regulation of mitotic cell cycle 0.5384 Informative Inherited
Biological Process (BP) response to inorganic substance 0.01314 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.8366 Informative Inherited
Biological Process (BP) single-organism intracellular transport 1 Informative Inherited
Biological Process (BP) apoptotic process 0.9599 Informative Inherited
Biological Process (BP) muscle system process 0.5179 Informative Inherited
Biological Process (BP) monovalent inorganic cation transport 1 Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 0.06448 Informative Inherited
Biological Process (BP) aspartate family amino acid metabolic process 0.1135 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) cell projection organization 1 Informative Inherited
Biological Process (BP) organ morphogenesis 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 1 Informative Inherited
Biological Process (BP) embryonic organ development 0.6891 Informative Inherited
Biological Process (BP) purine ribonucleotide metabolic process 0.8653 Informative Inherited
Biological Process (BP) nucleoside monophosphate metabolic process 0.001174 Informative Inherited
Biological Process (BP) nucleoside triphosphate metabolic process 0.4979 Informative Inherited
Biological Process (BP) purine ribonucleoside metabolic process 0.004163 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.07912 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 1 Informative Inherited
Biological Process (BP) cytoskeleton organization 1 Informative Inherited
Biological Process (BP) actin filament-based process 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.6844 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.2986 Informative Inherited
Biological Process (BP) membrane lipid metabolic process 0.633 Informative Inherited
Biological Process (BP) liposaccharide metabolic process 0.012 Informative Inherited
Biological Process (BP) biological adhesion 1 Informative Inherited
Biological Process (BP) response to nutrient levels 0.5374 Informative Inherited
Biological Process (BP) cellular response to external stimulus 0.1171 Informative Inherited
Biological Process (BP) anion transport 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) polysaccharide metabolic process 0.1864 Informative Inherited
Biological Process (BP) neurological system process 0.9086 Informative Inherited
Biological Process (BP) response to light stimulus 0.2931 Informative Inherited
Biological Process (BP) single-organism behavior 0.9007 Informative Inherited
Biological Process (BP) gland development 0.9546 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.006972 Informative Inherited
Biological Process (BP) alpha-amino acid biosynthetic process 0.01292 Informative Inherited
Biological Process (BP) sulfur amino acid metabolic process 0.01127 Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 0.008104 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.03179 Informative Inherited
Biological Process (BP) organic hydroxy compound biosynthetic process 0.02212 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) embryonic morphogenesis 1 Informative Inherited
Biological Process (BP) sensory organ development 1 Informative Inherited
Biological Process (BP) synaptic transmission 1 Informative Inherited
Biological Process (BP) protein dephosphorylation 0.00000000005684 Highly Informative Direct
Biological Process (BP) sodium ion transport 0.0002728 Highly Informative Direct
Biological Process (BP) ER-nucleus signaling pathway 0.000678 Highly Informative Direct
Biological Process (BP) nucleus organization 0.00000001976 Highly Informative Direct
Biological Process (BP) mitochondrial membrane organization 0.00000000009391 Highly Informative Direct
Biological Process (BP) body fluid secretion 0.00001911 Highly Informative Direct
Biological Process (BP) locomotory behavior 0.00001067 Highly Informative Direct
Biological Process (BP) lipopolysaccharide metabolic process 0.0001426 Highly Informative Direct
Biological Process (BP) serine family amino acid metabolic process 0.0004991 Highly Informative Direct
Biological Process (BP) oligosaccharide metabolic process 0.000000116 Highly Informative Direct
Biological Process (BP) organophosphate ester transport 0.0000000000004808 Highly Informative Direct
Biological Process (BP) negative regulation of hormone metabolic process 0.000001072 Highly Informative Direct
Biological Process (BP) secretion by tissue 0.00001163 Highly Informative Direct
Biological Process (BP) amino acid salvage 0.00000001794 Highly Informative Direct
Biological Process (BP) positive regulation of lipid metabolic process 0.00001723 Highly Informative Direct
Biological Process (BP) negative regulation of lipid biosynthetic process 0.00003737 Highly Informative Direct
Biological Process (BP) L-methionine biosynthetic process 0.000000008616 Highly Informative Direct
Biological Process (BP) regulation of muscle system process 0.000000000006968 Highly Informative Direct
Biological Process (BP) response to transition metal nanoparticle 0.00000001052 Highly Informative Direct
Biological Process (BP) negative regulation of mitotic cell cycle phase transition 0.1693 Highly Informative Inherited
Biological Process (BP) regulation of G1/S transition of mitotic cell cycle 0.00345 Highly Informative Inherited
Biological Process (BP) mitochondrial transport 0.01075 Highly Informative Inherited
Biological Process (BP) regulation of membrane permeability 0.002741 Highly Informative Inherited
Biological Process (BP) extrinsic apoptotic signaling pathway 0.01296 Highly Informative Inherited
Biological Process (BP) ear development 0.0713 Highly Informative Inherited
Biological Process (BP) epidermis development 0.004275 Highly Informative Inherited
Biological Process (BP) transition metal ion homeostasis 0.8772 Highly Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 0.02557 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.3126 Highly Informative Inherited
Biological Process (BP) sensory perception 0.4048 Highly Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0.001963 Highly Informative Inherited
Biological Process (BP) calcium ion transport 0.02126 Highly Informative Inherited
Biological Process (BP) regulation of steroid biosynthetic process 0.8212 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.2702 Highly Informative Inherited
Biological Process (BP) glycolipid biosynthetic process 0.1018 Highly Informative Inherited
Biological Process (BP) cell adhesion 1 Highly Informative Inherited
Biological Process (BP) response to toxic substance 0.009326 Highly Informative Inherited
Biological Process (BP) deoxyribonucleotide metabolic process 0.02559 Highly Informative Inherited
Biological Process (BP) cellular polysaccharide biosynthetic process 0.004315 Highly Informative Inherited
Biological Process (BP) learning or memory 0.1461 Highly Informative Inherited
Biological Process (BP) transition metal ion transport 0.2268 Highly Informative Inherited
Biological Process (BP) nucleoside monophosphate catabolic process 0.009241 Highly Informative Inherited
Biological Process (BP) purine nucleoside triphosphate catabolic process 0.3146 Highly Informative Inherited
Biological Process (BP) purine ribonucleotide catabolic process 0.498 Highly Informative Inherited
Biological Process (BP) ribonucleoside triphosphate catabolic process 0.2711 Highly Informative Inherited
Biological Process (BP) purine ribonucleoside catabolic process 0.3021 Highly Informative Inherited
Biological Process (BP) alditol metabolic process 0.1277 Highly Informative Inherited
Biological Process (BP) polyol biosynthetic process 0.001039 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.7293 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.9648 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 1 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.1312 Highly Informative Inherited
Biological Process (BP) regulation of neurotransmitter levels 1 Highly Informative Inherited
Biological Process (BP) neurotransmitter transport 1 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) binding 0.8775 Least Informative Inherited
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) cation binding 0 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.0003623 Moderately Informative Direct
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) isomerase activity 1 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 0.001981 Moderately Informative Inherited
Molecular Function (MF) nucleotide binding 0.00001405 Informative Direct
Molecular Function (MF) magnesium ion binding 0 Informative Direct
Molecular Function (MF) phosphatase activity 0 Informative Direct
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 0 Informative Direct
Molecular Function (MF) active transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) purine ribonucleoside binding 0.000000005587 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.000000001355 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0.0000000000008626 Informative Direct
Molecular Function (MF) enzyme binding 0.4558 Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 0.1822 Informative Inherited
Molecular Function (MF) monovalent inorganic cation transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.03707 Informative Inherited
Molecular Function (MF) ATP binding 0.00000000000001871 Highly Informative Direct
Molecular Function (MF) UDP-glycosyltransferase activity 0.0001609 Highly Informative Direct
Molecular Function (MF) calcium ion transmembrane transporter activity 0.000323 Highly Informative Direct
Molecular Function (MF) intramolecular transferase activity 0.000002233 Highly Informative Direct
Molecular Function (MF) ATPase activity, coupled to transmembrane movement of ions 0 Highly Informative Direct
Molecular Function (MF) transition metal ion transmembrane transporter activity 0.0001108 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring hexosyl groups 0.002536 Highly Informative Inherited
Molecular Function (MF) protein domain specific binding 0.1877 Highly Informative Inherited
Molecular Function (MF) hydrogen ion transmembrane transporter activity 0.2726 Highly Informative Inherited
Molecular Function (MF) phosphoprotein phosphatase activity 1 Highly Informative Inherited
Molecular Function (MF) lipid transporter activity 0.00191 Highly Informative Inherited
Molecular Function (MF) sodium ion transmembrane transporter activity 0.04352 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.0000000003161 Least Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.02323 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.5617 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0 Moderately Informative Direct
Cellular Component (CC) membrane region 0.000001077 Moderately Informative Direct
Cellular Component (CC) intrinsic component of membrane 0.1958 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) plasma membrane part 0.1209 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 0.001386 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 0.001485 Moderately Informative Inherited
Cellular Component (CC) mitochondrial part 1 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 0.000000005842 Informative Direct
Cellular Component (CC) Golgi apparatus 0.00000000006705 Informative Direct
Cellular Component (CC) vacuolar part 0.0001222 Informative Direct
Cellular Component (CC) integral component of membrane 0.04908 Informative Inherited
Cellular Component (CC) transporter complex 0.0154 Informative Inherited
Cellular Component (CC) nuclear envelope 0.002606 Informative Inherited
Cellular Component (CC) contractile fiber part 0.01226 Informative Inherited
Cellular Component (CC) intrinsic component of plasma membrane 1 Informative Inherited
Cellular Component (CC) mitochondrial membrane part 0.1646 Informative Inherited
Cellular Component (CC) trans-Golgi network 0.000000004783 Highly Informative Direct
Cellular Component (CC) protein serine/threonine phosphatase complex 0.00000002764 Highly Informative Direct
Cellular Component (CC) sarcoplasmic reticulum 0.0000000003087 Highly Informative Direct
Cellular Component (CC) sarcomere 0.0007756 Highly Informative Direct
Cellular Component (CC) nuclear membrane 0.0000003292 Highly Informative Direct
Cellular Component (CC) sarcolemma 0.00007507 Highly Informative Direct
Cellular Component (CC) integral component of plasma membrane 0.8344 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases1Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Hydro-lyases0.0001661Moderately InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides; catalyzing transmembran0InformativeDirect
Enzyme Commission (EC)Phosphotransferases (phosphomutases)0.00005104InformativeDirect
Enzyme Commission (EC)Potassium-transporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Proton-exporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Phospholipid-translocating ATPase0Highly InformativeDirect
Enzyme Commission (EC)Sodium/potassium-exchanging ATPase0Highly InformativeDirect
Enzyme Commission (EC)Inorganic diphosphatase0Highly InformativeDirect
Enzyme Commission (EC)Calcium-transporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Copper-exporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Histidinol-phosphatase0Highly InformativeDirect
Enzyme Commission (EC)Cu(+) exporting ATPase0.0000000000001039Highly InformativeDirect
Enzyme Commission (EC)Cadmium-exporting ATPase0.000000000006865Highly InformativeDirect
Enzyme Commission (EC)Hydrogen/potassium-exchanging ATPase0.0000000004443Highly InformativeDirect
Enzyme Commission (EC)Zinc-exporting ATPase0.000000007143Highly InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.002368Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.08705Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.1511Least InformativeInherited
Worm Phenotype (WP)chemical response variant0.1597Moderately InformativeInherited
Worm Phenotype (WP)nicotine response variant0.02052InformativeInherited
Worm Phenotype (WP)lipid metabolism variant0.08308InformativeInherited
Worm Phenotype (WP)cell membrane morphology variant0.00000001197Highly InformativeDirect
Worm Phenotype (WP)nicotine hypersensitive0.000001923Highly InformativeDirect
Worm Phenotype (WP)lipid composition variant0.00003424Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)sporangium0.00000009694Least InformativeDirect
Plant ANatomical entity (PAN)whole plant0.002097Least InformativeInherited
Plant ANatomical entity (PAN)portion of meristem tissue0.02505Least InformativeInherited
Plant ANatomical entity (PAN)microsporophyll0.1446Least InformativeInherited
Plant ANatomical entity (PAN)shoot axis0.1922Least InformativeInherited
Plant ANatomical entity (PAN)gamete0.00001662InformativeDirect
Plant ANatomical entity (PAN)pollen tube cell0.0004188InformativeDirect
Plant ANatomical entity (PAN)primordium0.002516InformativeInherited
Plant ANatomical entity (PAN)portion of ground tissue0.006588InformativeInherited
Plant ANatomical entity (PAN)parenchyma cell0.000002926Highly InformativeDirect
Plant ANatomical entity (PAN)vegetative shoot apex0.00002743Highly InformativeDirect
Plant ANatomical entity (PAN)phyllome primordium0.00003442Highly InformativeDirect
Plant ANatomical entity (PAN)mesophyll1Highly InformativeInherited
Plant structure DEvelopment stage (PDE)pollen development stage0.0000799Moderately InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.00000000000000991Moderately InformativeDirect
Enzyme Commission (EC)Carbon-oxygen lyases0.2018Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Hexosyltransferases0.0375InformativeInherited
Enzyme Commission (EC)Intramolecular transferases (mutases)0.4825InformativeInherited
Enzyme Commission (EC)In phosphorous-containing anhydrides1InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides; catalyzing transmembrane movement of substances0Highly InformativeDirect
Enzyme Commission (EC)Phosphotransferases (phosphomutases)0.00005729Highly InformativeDirect
Enzyme Commission (EC)Acting on ether bonds1Highly InformativeInherited

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)alimentary tract and metabolism0.03254Least InformativeInherited
Drugbank ATC_code (DB)nervous system0.07218Least InformativeInherited
Drugbank ATC_code (DB)other analgesics and antipyretics0.001144Moderately InformativeInherited
Drugbank ATC_code (DB)drugs for acid related disorders0.00005079InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Biological processProtein transport1Moderately InformativeInherited
Biological processLipid transport0.0000000000177InformativeDirect
Biological processCalcium transport0Highly InformativeDirect
Biological processMethionine biosynthesis0Highly InformativeDirect
Biological processPotassium transport0Highly InformativeDirect
Biological processNucleotide metabolism7.057e-16Highly InformativeDirect
Biological processSodium transport0.00000000005253Highly InformativeDirect
Biological processTranslocation0.0000000004858Highly InformativeDirect
Biological processLipopolysaccharide biosynthesis0.000001648Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus0.0003848Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentGolgi apparatus0.000000000002131Moderately InformativeDirect
Cellular componentCell membrane0.0001294Moderately InformativeDirect
Cellular componentPeriplasm0.0003962InformativeDirect
Cellular componentSarcoplasmic reticulum0Highly InformativeDirect
Coding sequence diversityAlternative splicing0.0000000003159Least InformativeDirect
DiseaseDisease mutation0.00003916Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionNucleotide-binding0.000000005188Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Molecular functionATP-binding0.0000000000009963Moderately InformativeDirect
Molecular functionCalmodulin-binding0InformativeDirect
Molecular functionCopper0InformativeDirect
Molecular functionPotassium0InformativeDirect
Molecular functionSodium0InformativeDirect
Molecular functionCadmium0Highly InformativeDirect
Molecular functionSchiff base0Highly InformativeDirect
Molecular functionChloride0.000000000005446Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationProtein phosphatase0.000000006532InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationNitration0.00007594InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)amino-acid metabolism0Least InformativeDirect
UniPathway (UP)carbohydrate metabolism0.2069Least InformativeInherited
UniPathway (UP)biopolymer metabolism1Least InformativeInherited
UniPathway (UP)lipid metabolism1Least InformativeInherited
UniPathway (UP)proteinogenic amino-acid biosynthesis0Moderately InformativeDirect
UniPathway (UP)glycan metabolism0Moderately InformativeDirect
UniPathway (UP)organic acid metabolism0Moderately InformativeDirect
UniPathway (UP)nucleotide metabolism0.0004232Moderately InformativeDirect
UniPathway (UP)carbohydrate biosynthesis0.0236Moderately InformativeInherited
UniPathway (UP)biopolymer biosynthesis0.1234Moderately InformativeInherited
UniPathway (UP)membrane lipid metabolism0.1643Moderately InformativeInherited
UniPathway (UP)amine and polyamine metabolism0.4585Moderately InformativeInherited
UniPathway (UP)lipid biosynthesis1Moderately InformativeInherited
UniPathway (UP)cellular component biogenesis1Moderately InformativeInherited
UniPathway (UP)nucleotide-sugar biosynthesis0InformativeDirect
UniPathway (UP)organic acid biosynthesis0InformativeDirect
UniPathway (UP)L-methionine biosynthesis0InformativeDirect
UniPathway (UP)amino-sugar metabolism0.0003077InformativeDirect
UniPathway (UP)lipopolysaccharide biosynthesis0.022InformativeInherited
UniPathway (UP)phospholipid metabolism0.5996InformativeInherited
UniPathway (UP)amine and polyamine biosynthesis1InformativeInherited
UniPathway (UP)trehalose metabolism0Highly InformativeDirect
UniPathway (UP)L-methionine biosynthesis via salvage pathway0Highly InformativeDirect
UniPathway (UP)LPS core biosynthesis0.000000000000378Highly InformativeDirect
UniPathway (UP)sucrose biosynthesis0.0000000000004149Highly InformativeDirect
UniPathway (UP)GDP-alpha-D-mannose biosynthesis0.000000000000598Highly InformativeDirect
UniPathway (UP)Lipooligosaccharide metabolism0.0000000005606Highly InformativeDirect
UniPathway (UP)amino-sugar biosynthesis0.0000002697Highly InformativeDirect
UniPathway (UP)L-serine biosynthesis0.000002994Highly InformativeDirect
UniPathway (UP)phosphatidylglycerol biosynthesis0.000005547Highly InformativeDirect
UniPathway (UP)ADP-L-glycero-beta-D-manno-heptose biosynthesis0.0005019Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Fly Anatomy (FA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 63 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a HAD-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 63 hidden Markov models representing the HAD-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Fly Anatomy (FA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]