SUPERFAMILY 1.75 HMM library and genome assignments server


HAD-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   HAD-like [ 56783]
Superfamily:   HAD-like [ 56784] (25)
Families:   Probable phosphatase YrbI [ 69467]
  HAD-related [ 56785] (2)
  beta-Phosphoglucomutase-like [ 75173] (9)
  YihX-like [ 56789] (2)
  Phosphonoacetaldehyde hydrolase-like [ 56792] (2)
  Phosphoserine phosphatase [ 64511]
  5'(3')-deoxyribonucleotidase (dNT-2) [ 82382]
  Homoserine kinase ThrH [ 102304]
  Class B acid phosphatase, AphA [ 102307]
  Hypothetical protein MW1667 (SA1546) [ 102310]
  phosphatase domain of polynucleotide kinase [ 82385] (2)
  Predicted hydrolases Cof [ 82388] (11)
  NagD-like [ 102317] (6)
  Meta-cation ATPase, catalytic domain P [ 81656] (2)
  Trehalose-phosphatase [ 110506]
  NLI interacting factor-like phosphatase [ 110509]
  Magnesium-dependent phosphatase-1, Mdp1 [ 117509]
  Hypothetical protein VC0232 [ 117512]
  Histidinol phosphatase-like [ 142177] (3)
  MtnX-like [ 142180]
  Pyrimidine 5'-nucleotidase (UMPH-1) [ 142183]
  Enolase-phosphatase E1 [ 142186] (2)
  5' nucleotidase-like [ 142191]
  AF1437-like [ 159537]
  BT0820-like [ 159540]


Superfamily statistics
Genomes (2,480) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 72,194 181,565 77
Proteins 71,783 181,101 77


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biosynthetic process0.90810.2952Least InformativeInherited
Biological Process (BP)single-organism metabolic process10.002724Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)regulation of metabolic process11Least InformativeInherited
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)heterocycle metabolic process11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process11Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.99431Least InformativeInherited
Biological Process (BP)protein metabolic process11Least InformativeInherited
Biological Process (BP)carbohydrate metabolic process0.00068258.724e-05Moderately InformativeDirect
Biological Process (BP)cellular amino acid metabolic process0.00016310.0001014Moderately InformativeDirect
Biological Process (BP)small molecule biosynthetic process9.772e-060.000383Moderately InformativeDirect
Biological Process (BP)organonitrogen compound biosynthetic process0.051770.02695Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.22321Moderately InformativeInherited
Biological Process (BP)regulation of cellular metabolic process11Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.74651Moderately InformativeInherited
Biological Process (BP)regulation of biosynthetic process0.44851Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process0.61721Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process00.006316Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process0.96840.0001984Moderately InformativeInherited
Biological Process (BP)cellular catabolic process11Moderately InformativeInherited
Biological Process (BP)nucleobase-containing small molecule metabolic process0.10534.115e-07Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process11Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process0.015741.862e-08Moderately InformativeInherited
Biological Process (BP)cellular lipid metabolic process10.5272Moderately InformativeInherited
Biological Process (BP)lipid biosynthetic process0.30920.2611Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process0.80231Moderately InformativeInherited
Biological Process (BP)organelle organization0.44820.4592Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.0055110.6647Moderately InformativeInherited
Biological Process (BP)cellular membrane organization0.00014316.291e-14InformativeDirect
Biological Process (BP)carbohydrate biosynthetic process0.00038988.879e-08InformativeDirect
Biological Process (BP)dephosphorylation00InformativeDirect
Biological Process (BP)regulation of lipid metabolic process1.232e-074.647e-08InformativeDirect
Biological Process (BP)cellular metabolic compound salvage0.00055553.331e-05InformativeDirect
Biological Process (BP)alpha-amino acid biosynthetic process2.48e-061.474e-05InformativeDirect
Biological Process (BP)aspartate family amino acid metabolic process0.057790.2539InformativeInherited
Biological Process (BP)sulfur compound biosynthetic process0.024730.06803InformativeInherited
Biological Process (BP)sulfur amino acid metabolic process0.035810.1499InformativeInherited
Biological Process (BP)amine biosynthetic process0.00033130.003147InformativeInherited
Biological Process (BP)positive regulation of cellular biosynthetic process0.0068071InformativeInherited
Biological Process (BP)nucleobase-containing compound catabolic process0.260.0003667InformativeInherited
Biological Process (BP)organophosphate catabolic process0.053332.327e-06InformativeInherited
Biological Process (BP)carbohydrate derivative catabolic process0.094233.923e-05InformativeInherited
Biological Process (BP)cellular carbohydrate metabolic process0.001522.442e-08InformativeInherited
Biological Process (BP)polysaccharide metabolic process0.053480.1783InformativeInherited
Biological Process (BP)protein dephosphorylation2.156e-060Highly InformativeDirect
Biological Process (BP)nucleus organization2.658e-113.668e-09Highly InformativeDirect
Biological Process (BP)serine family amino acid metabolic process5.447e-107.835e-15Highly InformativeDirect
Biological Process (BP)lipopolysaccharide biosynthetic process3.643e-050.0001839Highly InformativeDirect
Biological Process (BP)amino acid salvage1.279e-052.01e-06Highly InformativeDirect
Biological Process (BP)positive regulation of lipid metabolic process4.956e-114.507e-06Highly InformativeDirect
Biological Process (BP)L-methionine biosynthetic process1.073e-082.729e-09Highly InformativeDirect
Biological Process (BP)nucleotide catabolic process0.22060.02103Highly InformativeInherited
Biological Process (BP)deoxyribonucleotide metabolic process0.0044020.04553Highly InformativeInherited
Molecular Function (MF)hydrolase activity00Least InformativeDirect
Molecular Function (MF)binding3.069e-070.5428Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds00Moderately InformativeDirect
Molecular Function (MF)cation binding00Moderately InformativeDirect
Molecular Function (MF)isomerase activity0.31561Moderately InformativeInherited
Molecular Function (MF)phosphoric ester hydrolase activity00InformativeDirect
Molecular Function (MF)magnesium ion binding00Highly InformativeDirect
Molecular Function (MF)intramolecular transferase activity2.717e-097.357e-06Highly InformativeDirect
Cellular Component (CC)cytoplasmic part11.509e-08Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle10.01398Least InformativeInherited
Cellular Component (CC)intracellular organelle part11Least InformativeInherited
Cellular Component (CC)membrane10Least InformativeInherited
Cellular Component (CC)protein complex11Least InformativeInherited
Cellular Component (CC)endomembrane system0.018942.884e-12Moderately InformativeInherited
Cellular Component (CC)organelle envelope0.085230.001608Moderately InformativeInherited
Cellular Component (CC)nuclear part0.41911Moderately InformativeInherited
Cellular Component (CC)endoplasmic reticulum0.029780Moderately InformativeInherited
Cellular Component (CC)organelle membrane0.41641.335e-08Moderately InformativeInherited
Cellular Component (CC)nuclear envelope8.086e-075.741e-06InformativeDirect
Cellular Component (CC)endoplasmic reticulum membrane1.446e-057.715e-07InformativeDirect
Cellular Component (CC)protein serine/threonine phosphatase complex3.864e-132.03e-08Highly InformativeDirect
Cellular Component (CC)nuclear membrane4.932e-121.311e-08Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) biosynthetic process 0.2952 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.002724 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 8.724e-05 Moderately Informative Direct
Biological Process (BP) cellular amino acid metabolic process 0.0001014 Moderately Informative Direct
Biological Process (BP) ion transport 0 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0.0001984 Moderately Informative Direct
Biological Process (BP) homeostatic process 8.282e-10 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 0.000383 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 4.115e-07 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 1.862e-08 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 0.02695 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.933 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.8026 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 0.2611 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.006316 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 0.5272 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.4592 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.07761 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.6647 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) lipid transport 1.116e-05 Informative Direct
Biological Process (BP) cellular membrane organization 6.291e-14 Informative Direct
Biological Process (BP) carbohydrate biosynthetic process 8.879e-08 Informative Direct
Biological Process (BP) dephosphorylation 0 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 4.647e-08 Informative Direct
Biological Process (BP) metal ion transport 0.0001297 Informative Direct
Biological Process (BP) cellular cation homeostasis 1.472e-12 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 0.0003667 Informative Direct
Biological Process (BP) cellular metabolic compound salvage 3.331e-05 Informative Direct
Biological Process (BP) regulation of ion transport 5.803e-05 Informative Direct
Biological Process (BP) regulation of system process 1.086e-08 Informative Direct
Biological Process (BP) cellular carbohydrate metabolic process 2.442e-08 Informative Direct
Biological Process (BP) organophosphate catabolic process 2.327e-06 Informative Direct
Biological Process (BP) transmembrane transport 0 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 3.923e-05 Informative Direct
Biological Process (BP) alpha-amino acid biosynthetic process 1.474e-05 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.2018 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 1 Informative Inherited
Biological Process (BP) aspartate family amino acid metabolic process 0.2539 Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 0.06803 Informative Inherited
Biological Process (BP) sulfur amino acid metabolic process 0.1499 Informative Inherited
Biological Process (BP) amine biosynthetic process 0.003147 Informative Inherited
Biological Process (BP) sensory organ development 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.02479 Informative Inherited
Biological Process (BP) anion transport 1 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) single-organism behavior 0.06074 Informative Inherited
Biological Process (BP) secretion 1 Informative Inherited
Biological Process (BP) metal ion homeostasis 1 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 1 Informative Inherited
Biological Process (BP) negative regulation of cellular metabolic process 1 Informative Inherited
Biological Process (BP) cytoskeleton organization 1 Informative Inherited
Biological Process (BP) actin filament-based process 0.8197 Informative Inherited
Biological Process (BP) cell projection organization 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.7489 Informative Inherited
Biological Process (BP) cellular component movement 1 Informative Inherited
Biological Process (BP) locomotion 1 Informative Inherited
Biological Process (BP) localization of cell 1 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) membrane lipid metabolic process 0.5807 Informative Inherited
Biological Process (BP) biological adhesion 1 Informative Inherited
Biological Process (BP) response to external stimulus 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) response to inorganic substance 0.006946 Informative Inherited
Biological Process (BP) response to other organism 1 Informative Inherited
Biological Process (BP) polysaccharide metabolic process 0.1783 Informative Inherited
Biological Process (BP) response to light stimulus 0.4159 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 1 Informative Inherited
Biological Process (BP) gland development 0.6978 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.005367 Informative Inherited
Biological Process (BP) ribonucleoside metabolic process 1 Informative Inherited
Biological Process (BP) purine nucleoside metabolic process 0.3788 Informative Inherited
Biological Process (BP) purine nucleotide metabolic process 0.407 Informative Inherited
Biological Process (BP) ribose phosphate metabolic process 0.888 Informative Inherited
Biological Process (BP) nucleoside triphosphate metabolic process 0.3361 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.07909 Informative Inherited
Biological Process (BP) synaptic transmission 1 Informative Inherited
Biological Process (BP) regulation of sodium ion transport 0.0006987 Highly Informative Direct
Biological Process (BP) protein dephosphorylation 0 Highly Informative Direct
Biological Process (BP) regulation of muscle contraction 0 Highly Informative Direct
Biological Process (BP) response to osmotic stress 0.0004234 Highly Informative Direct
Biological Process (BP) ER-nucleus signaling pathway 0.000419 Highly Informative Direct
Biological Process (BP) nucleus organization 3.668e-09 Highly Informative Direct
Biological Process (BP) lactation 4.486e-06 Highly Informative Direct
Biological Process (BP) locomotory behavior 4.613e-05 Highly Informative Direct
Biological Process (BP) serine family amino acid metabolic process 7.835e-15 Highly Informative Direct
Biological Process (BP) lipopolysaccharide biosynthetic process 0.0001839 Highly Informative Direct
Biological Process (BP) purine ribonucleoside triphosphate metabolic process 6.27e-05 Highly Informative Direct
Biological Process (BP) oligosaccharide metabolic process 1.078e-06 Highly Informative Direct
Biological Process (BP) organophosphate ester transport 1.84e-13 Highly Informative Direct
Biological Process (BP) ion transmembrane transport 2.344e-05 Highly Informative Direct
Biological Process (BP) amino acid salvage 2.01e-06 Highly Informative Direct
Biological Process (BP) positive regulation of lipid metabolic process 4.507e-06 Highly Informative Direct
Biological Process (BP) negative regulation of lipid biosynthetic process 8.602e-06 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 6.561e-06 Highly Informative Direct
Biological Process (BP) L-methionine biosynthetic process 2.729e-09 Highly Informative Direct
Biological Process (BP) regulation of steroid biosynthetic process 0.8149 Highly Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 0.001764 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.1121 Highly Informative Inherited
Biological Process (BP) inner ear development 0.2785 Highly Informative Inherited
Biological Process (BP) calcium ion transport 0.06337 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.05794 Highly Informative Inherited
Biological Process (BP) membrane lipid biosynthetic process 0.1666 Highly Informative Inherited
Biological Process (BP) cell adhesion 1 Highly Informative Inherited
Biological Process (BP) cellular response to starvation 0.03294 Highly Informative Inherited
Biological Process (BP) response to toxic substance 0.002511 Highly Informative Inherited
Biological Process (BP) deoxyribonucleotide metabolic process 0.04553 Highly Informative Inherited
Biological Process (BP) learning or memory 0.4622 Highly Informative Inherited
Biological Process (BP) transition metal ion transport 0.1845 Highly Informative Inherited
Biological Process (BP) nucleotide catabolic process 0.02103 Highly Informative Inherited
Biological Process (BP) nucleoside triphosphate catabolic process 1 Highly Informative Inherited
Biological Process (BP) purine ribonucleoside catabolic process 0.4752 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.6791 Highly Informative Inherited
Biological Process (BP) regulation of neurotransmitter levels 0.9079 Highly Informative Inherited
Biological Process (BP) neurotransmitter transport 1 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.5428 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) cation binding 0 Moderately Informative Direct
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) organic cyclic compound binding 1 Moderately Informative Inherited
Molecular Function (MF) heterocyclic compound binding 1 Moderately Informative Inherited
Molecular Function (MF) isomerase activity 1 Moderately Informative Inherited
Molecular Function (MF) protein binding 1 Moderately Informative Inherited
Molecular Function (MF) nucleotide binding 7.532e-07 Informative Direct
Molecular Function (MF) active transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 1.194e-09 Informative Direct
Molecular Function (MF) phosphoric ester hydrolase activity 0 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 2.539e-12 Informative Direct
Molecular Function (MF) enzyme binding 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.01651 Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 0.3868 Informative Inherited
Molecular Function (MF) magnesium ion binding 0 Highly Informative Direct
Molecular Function (MF) lipid transporter activity 0.0001082 Highly Informative Direct
Molecular Function (MF) ATP binding 0 Highly Informative Direct
Molecular Function (MF) UDP-glycosyltransferase activity 8.971e-05 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring hexosyl groups 0.0009898 Highly Informative Direct
Molecular Function (MF) intramolecular transferase activity 7.357e-06 Highly Informative Direct
Molecular Function (MF) ATPase activity, coupled to transmembrane movement of ions 0 Highly Informative Direct
Molecular Function (MF) transition metal ion transmembrane transporter activity 6.82e-05 Highly Informative Direct
Molecular Function (MF) hydrogen ion transmembrane transporter activity 0.3199 Highly Informative Inherited
Molecular Function (MF) phosphoprotein phosphatase activity 1 Highly Informative Inherited
Molecular Function (MF) sodium ion transmembrane transporter activity 0.07473 Highly Informative Inherited
Molecular Function (MF) transcription factor binding 0.629 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1.509e-08 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.01398 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 4.913e-10 Moderately Informative Direct
Cellular Component (CC) endomembrane system 2.884e-12 Moderately Informative Direct
Cellular Component (CC) organelle membrane 1.335e-08 Moderately Informative Direct
Cellular Component (CC) organelle envelope 0.001608 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 0.2143 Moderately Informative Inherited
Cellular Component (CC) mitochondrial part 1 Moderately Informative Inherited
Cellular Component (CC) nuclear envelope 5.741e-06 Informative Direct
Cellular Component (CC) endoplasmic reticulum membrane 7.715e-07 Informative Direct
Cellular Component (CC) Golgi apparatus 1.657e-08 Informative Direct
Cellular Component (CC) vacuole 0.005293 Informative Inherited
Cellular Component (CC) neuron part 0.9034 Informative Inherited
Cellular Component (CC) contractile fiber part 0.01036 Informative Inherited
Cellular Component (CC) integral to membrane 0.003312 Informative Inherited
Cellular Component (CC) intrinsic to plasma membrane 1 Informative Inherited
Cellular Component (CC) mitochondrial membrane part 0.2694 Informative Inherited
Cellular Component (CC) trans-Golgi network 8.086e-10 Highly Informative Direct
Cellular Component (CC) protein serine/threonine phosphatase complex 2.03e-08 Highly Informative Direct
Cellular Component (CC) basolateral plasma membrane 5.478e-05 Highly Informative Direct
Cellular Component (CC) sarcoplasmic reticulum 2.889e-11 Highly Informative Direct
Cellular Component (CC) sarcomere 0.0009744 Highly Informative Direct
Cellular Component (CC) nuclear membrane 1.311e-08 Highly Informative Direct
Cellular Component (CC) cell body 0.004989 Highly Informative Inherited
Cellular Component (CC) integral to plasma membrane 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases1Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Hydro-lyases0.0001661Moderately InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides; catalyzing transmembran0InformativeDirect
Enzyme Commission (EC)Phosphotransferases (phosphomutases)5.104e-05InformativeDirect
Enzyme Commission (EC)Potassium-transporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Proton-exporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Phospholipid-translocating ATPase0Highly InformativeDirect
Enzyme Commission (EC)Sodium/potassium-exchanging ATPase0Highly InformativeDirect
Enzyme Commission (EC)Inorganic diphosphatase0Highly InformativeDirect
Enzyme Commission (EC)Calcium-transporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Copper-exporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Histidinol-phosphatase0Highly InformativeDirect
Enzyme Commission (EC)Cu(+) exporting ATPase1.039e-13Highly InformativeDirect
Enzyme Commission (EC)Cadmium-exporting ATPase6.865e-12Highly InformativeDirect
Enzyme Commission (EC)Hydrogen/potassium-exchanging ATPase4.443e-10Highly InformativeDirect
Enzyme Commission (EC)Zinc-exporting ATPase7.143e-09Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.3524Least InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.4313Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal ion homeostasis0.000435InformativeDirect
Mammalian Phenotype (MP)abnormal coat appearance0.1858InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.002368Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.08705Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.1511Least InformativeInherited
Worm Phenotype (WP)chemical response variant0.1597Moderately InformativeInherited
Worm Phenotype (WP)nicotine response variant0.02052InformativeInherited
Worm Phenotype (WP)lipid metabolism variant0.08308InformativeInherited
Worm Phenotype (WP)cell membrane morphology variant1.197e-08Highly InformativeDirect
Worm Phenotype (WP)nicotine hypersensitive1.923e-06Highly InformativeDirect
Worm Phenotype (WP)lipid composition variant3.424e-05Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)head0Least InformativeDirect

Document: ZA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)plant cell4.143e-09Least InformativeDirect
Plant ANatomical entity (PAN)sporangium7.534e-06Least InformativeDirect
Plant ANatomical entity (PAN)microgametophyte1.632e-05Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0.1372Least InformativeInherited
Plant ANatomical entity (PAN)shoot apex0.4354Least InformativeInherited
Plant ANatomical entity (PAN)portion of meristem tissue0.8529Least InformativeInherited
Plant ANatomical entity (PAN)guard cell0.0006201Moderately InformativeDirect
Plant ANatomical entity (PAN)primordium0.002349InformativeInherited
Plant ANatomical entity (PAN)portion of ground tissue0.01367InformativeInherited
Plant ANatomical entity (PAN)parenchyma cell4.217e-06Highly InformativeDirect
Plant ANatomical entity (PAN)vegetative shoot apex2.592e-05Highly InformativeDirect
Plant ANatomical entity (PAN)phyllome primordium3.252e-05Highly InformativeDirect
Plant structure DEvelopment stage (PDE)pollen development stage9.404e-05Moderately InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides4.77e-16Moderately InformativeDirect
Enzyme Commission (EC)Carbon-oxygen lyases0.1415Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Hexosyltransferases0.04131InformativeInherited
Enzyme Commission (EC)Intramolecular transferases (mutases)0.4521InformativeInherited
Enzyme Commission (EC)In phosphorous-containing anhydrides1InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides; catalyzing transmembrane movement of substances0Highly InformativeDirect
Enzyme Commission (EC)Phosphotransferases (phosphomutases)5.868e-05Highly InformativeDirect
Enzyme Commission (EC)Acting on ether bonds1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Biological processProtein transport1Moderately InformativeInherited
Biological processMethionine biosynthesis0Highly InformativeDirect
Biological processPotassium transport0Highly InformativeDirect
Biological processNucleotide metabolism4.622e-16Highly InformativeDirect
Biological processSodium transport4.672e-11Highly InformativeDirect
Biological processTranslocation2.726e-10Highly InformativeDirect
Biological processLipopolysaccharide biosynthesis2.476e-07Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus4.066e-05Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentGolgi apparatus2.008e-07Moderately InformativeDirect
Cellular componentPeriplasm0.0002479InformativeDirect
Cellular componentSarcoplasmic reticulum0Highly InformativeDirect
Coding sequence diversityAlternative splicing5.046e-10Least InformativeDirect
DiseaseDisease mutation0.0001747Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionNucleotide-binding5.382e-09Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Molecular functionCalmodulin-binding0InformativeDirect
Molecular functionCopper0InformativeDirect
Molecular functionPotassium0InformativeDirect
Molecular functionSodium0InformativeDirect
Molecular functionCadmium0Highly InformativeDirect
Molecular functionCalcium transport0Highly InformativeDirect
Molecular functionSchiff base0Highly InformativeDirect
Molecular functionChloride3.208e-12Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationProtein phosphatase4.258e-08InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationNitration6.845e-06Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)amino-acid metabolism0Least InformativeDirect
UniPathway (UP)carbohydrate metabolism0.2046Least InformativeInherited
UniPathway (UP)biopolymer metabolism1Least InformativeInherited
UniPathway (UP)lipid metabolism1Least InformativeInherited
UniPathway (UP)proteinogenic amino-acid biosynthesis0Moderately InformativeDirect
UniPathway (UP)glycan metabolism0Moderately InformativeDirect
UniPathway (UP)organic acid metabolism0Moderately InformativeDirect
UniPathway (UP)nucleotide metabolism0.0006027Moderately InformativeDirect
UniPathway (UP)carbohydrate biosynthesis0.02127Moderately InformativeInherited
UniPathway (UP)biopolymer biosynthesis0.1083Moderately InformativeInherited
UniPathway (UP)membrane lipid metabolism0.121Moderately InformativeInherited
UniPathway (UP)amine and polyamine metabolism0.4446Moderately InformativeInherited
UniPathway (UP)lipid biosynthesis1Moderately InformativeInherited
UniPathway (UP)cellular component biogenesis1Moderately InformativeInherited
UniPathway (UP)nucleotide-sugar biosynthesis0InformativeDirect
UniPathway (UP)organic acid biosynthesis0InformativeDirect
UniPathway (UP)L-methionine biosynthesis0InformativeDirect
UniPathway (UP)amino-sugar metabolism0.0002867InformativeDirect
UniPathway (UP)lipopolysaccharide biosynthesis0.01885InformativeInherited
UniPathway (UP)amine and polyamine biosynthesis0.9997InformativeInherited
UniPathway (UP)trehalose metabolism0Highly InformativeDirect
UniPathway (UP)L-methionine biosynthesis via salvage pathway0Highly InformativeDirect
UniPathway (UP)sucrose biosynthesis2.35e-13Highly InformativeDirect
UniPathway (UP)LPS core biosynthesis3.228e-13Highly InformativeDirect
UniPathway (UP)GDP-alpha-D-mannose biosynthesis9.186e-13Highly InformativeDirect
UniPathway (UP)Lipooligosaccharide metabolism5.24e-10Highly InformativeDirect
UniPathway (UP)amino-sugar biosynthesis2.722e-07Highly InformativeDirect
UniPathway (UP)L-serine biosynthesis4.162e-05Highly InformativeDirect
UniPathway (UP)LPS oligosaccharide biosynthesis0.001694Highly InformativeInherited

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 63 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a HAD-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 63 hidden Markov models representing the HAD-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]