SUPERFAMILY 1.75 HMM library and genome assignments server


HAD-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   HAD-like [ 56783]
Superfamily:   HAD-like [ 56784] (25)
Families:   Probable phosphatase YrbI [ 69467]
  HAD-related [ 56785] (2)
  beta-Phosphoglucomutase-like [ 75173] (9)
  YihX-like [ 56789] (2)
  Phosphonoacetaldehyde hydrolase-like [ 56792] (2)
  Phosphoserine phosphatase [ 64511]
  5'(3')-deoxyribonucleotidase (dNT-2) [ 82382]
  Homoserine kinase ThrH [ 102304]
  Class B acid phosphatase, AphA [ 102307]
  Hypothetical protein MW1667 (SA1546) [ 102310]
  phosphatase domain of polynucleotide kinase [ 82385] (2)
  Predicted hydrolases Cof [ 82388] (11)
  NagD-like [ 102317] (6)
  Meta-cation ATPase, catalytic domain P [ 81656] (2)
  Trehalose-phosphatase [ 110506]
  NLI interacting factor-like phosphatase [ 110509]
  Magnesium-dependent phosphatase-1, Mdp1 [ 117509]
  Hypothetical protein VC0232 [ 117512]
  Histidinol phosphatase-like [ 142177] (3)
  MtnX-like [ 142180]
  Pyrimidine 5'-nucleotidase (UMPH-1) [ 142183]
  Enolase-phosphatase E1 [ 142186] (2)
  5' nucleotidase-like [ 142191]
  AF1437-like [ 159537]
  BT0820-like [ 159540]


Superfamily statistics
Genomes (3,192) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 85,626 181,565 77
Proteins 85,177 181,101 77


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of metabolic process11Least InformativeInherited
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)heterocycle metabolic process11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process11Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis11Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)single-organism metabolic process10.9978Least InformativeInherited
Biological Process (BP)protein metabolic process0.78171Least InformativeInherited
Biological Process (BP)carbohydrate metabolic process3.469e-050.0003007Moderately InformativeDirect
Biological Process (BP)positive regulation of metabolic process0.31981Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.76791Moderately InformativeInherited
Biological Process (BP)cellular catabolic process11Moderately InformativeInherited
Biological Process (BP)cofactor metabolic process11Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process0.83950.008483Moderately InformativeInherited
Biological Process (BP)cellular amino acid metabolic process0.094180.2281Moderately InformativeInherited
Biological Process (BP)single-organism biosynthetic process0.0025290.02368Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process0.70070.5705Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.48991Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.033220.001221Moderately InformativeInherited
Biological Process (BP)nucleobase-containing small molecule metabolic process0.09740.0001605Moderately InformativeInherited
Biological Process (BP)organic cyclic compound catabolic process0.67280.02403Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process0.013984.258e-06Moderately InformativeInherited
Biological Process (BP)cellular lipid metabolic process10.8741Moderately InformativeInherited
Biological Process (BP)lipid biosynthetic process0.062250.06238Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process0.5341Moderately InformativeInherited
Biological Process (BP)organelle organization0.53890.82Moderately InformativeInherited
Biological Process (BP)sulfur compound metabolic process0.72790.9328Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.0017090.3723Moderately InformativeInherited
Biological Process (BP)carbohydrate biosynthetic process1.903e-064.365e-10InformativeDirect
Biological Process (BP)dephosphorylation00InformativeDirect
Biological Process (BP)regulation of lipid metabolic process1.699e-072.724e-07InformativeDirect
Biological Process (BP)cellular metabolic compound salvage0.00022971.388e-05InformativeDirect
Biological Process (BP)organophosphate catabolic process0.00097938.703e-07InformativeDirect
Biological Process (BP)membrane organization4.627e-050InformativeDirect
Biological Process (BP)sulfur compound biosynthetic process0.0086520.02932InformativeInherited
Biological Process (BP)alpha-amino acid biosynthetic process0.007140.01271InformativeInherited
Biological Process (BP)sulfur amino acid metabolic process0.00082820.009493InformativeInherited
Biological Process (BP)positive regulation of cellular biosynthetic process0.008711InformativeInherited
Biological Process (BP)nucleobase-containing compound catabolic process0.33550.005829InformativeInherited
Biological Process (BP)carbohydrate derivative catabolic process0.26020.0009966InformativeInherited
Biological Process (BP)cellular carbohydrate metabolic process0.0010290.0001063InformativeInherited
Biological Process (BP)polysaccharide metabolic process0.030260.1578InformativeInherited
Biological Process (BP)aspartate family amino acid metabolic process0.0021520.1044InformativeInherited
Biological Process (BP)protein dephosphorylation0.00073811.168e-11Highly InformativeDirect
Biological Process (BP)nucleus organization1.128e-115.67e-09Highly InformativeDirect
Biological Process (BP)lipopolysaccharide metabolic process6.804e-060.0001384Highly InformativeDirect
Biological Process (BP)amino acid salvage8.068e-094.994e-09Highly InformativeDirect
Biological Process (BP)positive regulation of lipid metabolic process6.297e-111.742e-05Highly InformativeDirect
Biological Process (BP)L-methionine biosynthetic process1.239e-083.367e-09Highly InformativeDirect
Biological Process (BP)deoxyribonucleotide metabolic process0.0019440.02171Highly InformativeInherited
Biological Process (BP)cellular polysaccharide biosynthetic process0.0010320.003522Highly InformativeInherited
Biological Process (BP)serine family amino acid metabolic process0.0015280.0004406Highly InformativeInherited
Molecular Function (MF)hydrolase activity00Least InformativeDirect
Molecular Function (MF)binding4.548e-060.6618Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds00Moderately InformativeDirect
Molecular Function (MF)cation binding00Moderately InformativeDirect
Molecular Function (MF)isomerase activity0.097581Moderately InformativeInherited
Molecular Function (MF)magnesium ion binding00InformativeDirect
Molecular Function (MF)phosphatase activity00InformativeDirect
Molecular Function (MF)intramolecular transferase activity1.888e-098.764e-06Highly InformativeDirect
Cellular Component (CC)cytoplasmic part14.674e-08Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle10.08095Least InformativeInherited
Cellular Component (CC)intracellular organelle part11Least InformativeInherited
Cellular Component (CC)membrane10Least InformativeInherited
Cellular Component (CC)protein complex11Least InformativeInherited
Cellular Component (CC)organelle membrane0.49611.908e-09Moderately InformativeInherited
Cellular Component (CC)organelle envelope0.064590.0002704Moderately InformativeInherited
Cellular Component (CC)nuclear part0.32791Moderately InformativeInherited
Cellular Component (CC)endomembrane system0.012975.839e-15Moderately InformativeInherited
Cellular Component (CC)endoplasmic reticulum0.029790Moderately InformativeInherited
Cellular Component (CC)nuclear envelope7.644e-074.283e-06InformativeDirect
Cellular Component (CC)endoplasmic reticulum membrane1.787e-052.197e-07InformativeDirect
Cellular Component (CC)protein serine/threonine phosphatase complex4.024e-131.251e-08Highly InformativeDirect
Cellular Component (CC)nuclear membrane2.592e-121.452e-09Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.9978 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.0003007 Moderately Informative Direct
Biological Process (BP) ion transport 0 Moderately Informative Direct
Biological Process (BP) homeostatic process 3.027e-12 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.0001605 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 4.258e-06 Moderately Informative Direct
Biological Process (BP) cellular localization 0.8777 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.82 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) cofactor metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 0.8741 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.008483 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.2281 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.5705 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 0.06238 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.9882 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound catabolic process 0.02403 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.001221 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.1035 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.03209 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.9328 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.3723 Moderately Informative Inherited
Biological Process (BP) single-organism biosynthetic process 0.02368 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.08853 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) mitochondrion organization 5.607e-05 Informative Direct
Biological Process (BP) nucleoside monophosphate metabolic process 0.0004546 Informative Direct
Biological Process (BP) lipid localization 1.964e-12 Informative Direct
Biological Process (BP) carbohydrate biosynthetic process 4.365e-10 Informative Direct
Biological Process (BP) dephosphorylation 0 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 2.724e-07 Informative Direct
Biological Process (BP) metal ion transport 6.032e-10 Informative Direct
Biological Process (BP) cellular metabolic compound salvage 1.388e-05 Informative Direct
Biological Process (BP) regulation of ion transport 1.982e-05 Informative Direct
Biological Process (BP) regulation of system process 1.104e-07 Informative Direct
Biological Process (BP) cellular carbohydrate metabolic process 0.0001063 Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 0.000637 Informative Direct
Biological Process (BP) organophosphate catabolic process 8.703e-07 Informative Direct
Biological Process (BP) cation homeostasis 0.000457 Informative Direct
Biological Process (BP) cellular chemical homeostasis 9.23e-14 Informative Direct
Biological Process (BP) transmembrane transport 0 Informative Direct
Biological Process (BP) membrane organization 0 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0.0009966 Informative Direct
Biological Process (BP) glycosyl compound catabolic process 0.0008168 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.6525 Informative Inherited
Biological Process (BP) cell death 1 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 1 Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 0.02932 Informative Inherited
Biological Process (BP) alpha-amino acid biosynthetic process 0.01271 Informative Inherited
Biological Process (BP) sulfur amino acid metabolic process 0.009493 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) sensory organ development 1 Informative Inherited
Biological Process (BP) nucleoside triphosphate metabolic process 0.363 Informative Inherited
Biological Process (BP) purine ribonucleotide metabolic process 0.8096 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.04333 Informative Inherited
Biological Process (BP) anion transport 1 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) single-organism behavior 0.04145 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 1 Informative Inherited
Biological Process (BP) cytoskeleton organization 1 Informative Inherited
Biological Process (BP) actin filament-based process 0.9411 Informative Inherited
Biological Process (BP) cell projection organization 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.9424 Informative Inherited
Biological Process (BP) cellular component movement 1 Informative Inherited
Biological Process (BP) locomotion 1 Informative Inherited
Biological Process (BP) localization of cell 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) membrane lipid metabolic process 0.591 Informative Inherited
Biological Process (BP) biological adhesion 1 Informative Inherited
Biological Process (BP) response to nutrient levels 0.3605 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) response to inorganic substance 0.05468 Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 0.005829 Informative Inherited
Biological Process (BP) polysaccharide metabolic process 0.1578 Informative Inherited
Biological Process (BP) response to light stimulus 0.3321 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 1 Informative Inherited
Biological Process (BP) gland development 0.7093 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.007992 Informative Inherited
Biological Process (BP) glycerolipid metabolic process 0.0184 Informative Inherited
Biological Process (BP) aspartate family amino acid metabolic process 0.1044 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.2407 Informative Inherited
Biological Process (BP) organic hydroxy compound biosynthetic process 0.004901 Informative Inherited
Biological Process (BP) cell-cell signaling 1 Informative Inherited
Biological Process (BP) transmission of nerve impulse 1 Informative Inherited
Biological Process (BP) regulation of sodium ion transport 0.0001729 Highly Informative Direct
Biological Process (BP) protein dephosphorylation 1.168e-11 Highly Informative Direct
Biological Process (BP) regulation of muscle contraction 0 Highly Informative Direct
Biological Process (BP) response to osmotic stress 0.0002955 Highly Informative Direct
Biological Process (BP) ER-nucleus signaling pathway 0.000646 Highly Informative Direct
Biological Process (BP) nucleus organization 5.67e-09 Highly Informative Direct
Biological Process (BP) lactation 3.662e-06 Highly Informative Direct
Biological Process (BP) locomotory behavior 8.607e-06 Highly Informative Direct
Biological Process (BP) lipopolysaccharide metabolic process 0.0001384 Highly Informative Direct
Biological Process (BP) serine family amino acid metabolic process 0.0004406 Highly Informative Direct
Biological Process (BP) oligosaccharide metabolic process 3.938e-06 Highly Informative Direct
Biological Process (BP) organophosphate ester transport 4.194e-13 Highly Informative Direct
Biological Process (BP) negative regulation of hormone metabolic process 7.693e-07 Highly Informative Direct
Biological Process (BP) ion transmembrane transport 0 Highly Informative Direct
Biological Process (BP) amino acid salvage 4.994e-09 Highly Informative Direct
Biological Process (BP) positive regulation of lipid metabolic process 1.742e-05 Highly Informative Direct
Biological Process (BP) ATP metabolic process 0.0001722 Highly Informative Direct
Biological Process (BP) negative regulation of lipid biosynthetic process 2.09e-05 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 1.145e-05 Highly Informative Direct
Biological Process (BP) L-methionine biosynthetic process 3.367e-09 Highly Informative Direct
Biological Process (BP) mitochondrial transport 0.4478 Highly Informative Inherited
Biological Process (BP) extrinsic apoptotic signaling pathway 0.01204 Highly Informative Inherited
Biological Process (BP) regulation of steroid biosynthetic process 0.8487 Highly Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 0.01142 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.2001 Highly Informative Inherited
Biological Process (BP) inner ear development 0.254 Highly Informative Inherited
Biological Process (BP) monovalent inorganic cation transport 1 Highly Informative Inherited
Biological Process (BP) calcium ion transport 0.068 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.1084 Highly Informative Inherited
Biological Process (BP) transition metal ion homeostasis 0.6381 Highly Informative Inherited
Biological Process (BP) glycolipid biosynthetic process 0.09225 Highly Informative Inherited
Biological Process (BP) cell adhesion 1 Highly Informative Inherited
Biological Process (BP) cellular response to starvation 0.05604 Highly Informative Inherited
Biological Process (BP) response to toxic substance 0.005201 Highly Informative Inherited
Biological Process (BP) deoxyribonucleotide metabolic process 0.02171 Highly Informative Inherited
Biological Process (BP) cellular polysaccharide biosynthetic process 0.003522 Highly Informative Inherited
Biological Process (BP) transition metal ion transport 0.2443 Highly Informative Inherited
Biological Process (BP) acylglycerol metabolic process 0.05141 Highly Informative Inherited
Biological Process (BP) polyol metabolic process 0.7334 Highly Informative Inherited
Biological Process (BP) alcohol biosynthetic process 0.0463 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.6805 Highly Informative Inherited
Biological Process (BP) regulation of neurotransmitter levels 0.9364 Highly Informative Inherited
Biological Process (BP) neurotransmitter transport 1 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.6618 Least Informative Inherited
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) cation binding 0 Moderately Informative Direct
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) isomerase activity 1 Moderately Informative Inherited
Molecular Function (MF) nucleotide binding 9.098e-06 Informative Direct
Molecular Function (MF) magnesium ion binding 0 Informative Direct
Molecular Function (MF) phosphatase activity 0 Informative Direct
Molecular Function (MF) active transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 3.872e-10 Informative Direct
Molecular Function (MF) purine ribonucleoside binding 4.058e-09 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 9.312e-10 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) enzyme binding 0.5693 Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 0.2288 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.02581 Informative Inherited
Molecular Function (MF) ATP binding 1.322e-14 Highly Informative Direct
Molecular Function (MF) UDP-glycosyltransferase activity 0.0001065 Highly Informative Direct
Molecular Function (MF) intramolecular transferase activity 8.764e-06 Highly Informative Direct
Molecular Function (MF) ATPase activity, coupled to transmembrane movement of ions 0 Highly Informative Direct
Molecular Function (MF) transition metal ion transmembrane transporter activity 0.0001411 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring hexosyl groups 0.001721 Highly Informative Inherited
Molecular Function (MF) hydrogen ion transmembrane transporter activity 0.3928 Highly Informative Inherited
Molecular Function (MF) phosphoprotein phosphatase activity 1 Highly Informative Inherited
Molecular Function (MF) lipid transporter activity 0.003316 Highly Informative Inherited
Molecular Function (MF) sodium ion transmembrane transporter activity 0.0751 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 4.674e-08 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.08095 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0 Moderately Informative Direct
Cellular Component (CC) endomembrane system 5.839e-15 Moderately Informative Direct
Cellular Component (CC) organelle membrane 1.908e-09 Moderately Informative Direct
Cellular Component (CC) organelle envelope 0.0002704 Moderately Informative Direct
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) plasma membrane part 0.1668 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 0.1555 Moderately Informative Inherited
Cellular Component (CC) mitochondrial part 1 Moderately Informative Inherited
Cellular Component (CC) nuclear envelope 4.283e-06 Informative Direct
Cellular Component (CC) endoplasmic reticulum membrane 2.197e-07 Informative Direct
Cellular Component (CC) Golgi apparatus 1.415e-07 Informative Direct
Cellular Component (CC) vacuolar part 7.604e-05 Informative Direct
Cellular Component (CC) contractile fiber part 0.01022 Informative Inherited
Cellular Component (CC) integral to membrane 0.003737 Informative Inherited
Cellular Component (CC) intrinsic to plasma membrane 1 Informative Inherited
Cellular Component (CC) mitochondrial membrane part 0.1393 Informative Inherited
Cellular Component (CC) trans-Golgi network 1.627e-10 Highly Informative Direct
Cellular Component (CC) protein serine/threonine phosphatase complex 1.251e-08 Highly Informative Direct
Cellular Component (CC) basolateral plasma membrane 0.0001461 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 0.0001196 Highly Informative Direct
Cellular Component (CC) sarcoplasmic reticulum 4.286e-11 Highly Informative Direct
Cellular Component (CC) sarcomere 0.0009859 Highly Informative Direct
Cellular Component (CC) nuclear membrane 1.452e-09 Highly Informative Direct
Cellular Component (CC) integral to plasma membrane 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases1Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Hydro-lyases0.0001661Moderately InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides; catalyzing transmembran0InformativeDirect
Enzyme Commission (EC)Phosphotransferases (phosphomutases)5.104e-05InformativeDirect
Enzyme Commission (EC)Potassium-transporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Proton-exporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Phospholipid-translocating ATPase0Highly InformativeDirect
Enzyme Commission (EC)Sodium/potassium-exchanging ATPase0Highly InformativeDirect
Enzyme Commission (EC)Inorganic diphosphatase0Highly InformativeDirect
Enzyme Commission (EC)Calcium-transporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Copper-exporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Histidinol-phosphatase0Highly InformativeDirect
Enzyme Commission (EC)Cu(+) exporting ATPase1.039e-13Highly InformativeDirect
Enzyme Commission (EC)Cadmium-exporting ATPase6.865e-12Highly InformativeDirect
Enzyme Commission (EC)Hydrogen/potassium-exchanging ATPase4.443e-10Highly InformativeDirect
Enzyme Commission (EC)Zinc-exporting ATPase7.143e-09Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)integument phenotype0.6195Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal coat appearance0.2732InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.002368Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.08705Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.1511Least InformativeInherited
Worm Phenotype (WP)chemical response variant0.1597Moderately InformativeInherited
Worm Phenotype (WP)nicotine response variant0.02052InformativeInherited
Worm Phenotype (WP)lipid metabolism variant0.08308InformativeInherited
Worm Phenotype (WP)cell membrane morphology variant1.197e-08Highly InformativeDirect
Worm Phenotype (WP)nicotine hypersensitive1.923e-06Highly InformativeDirect
Worm Phenotype (WP)lipid composition variant3.424e-05Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)sporangium9.694e-08Least InformativeDirect
Plant ANatomical entity (PAN)whole plant0.002097Least InformativeInherited
Plant ANatomical entity (PAN)portion of meristem tissue0.02505Least InformativeInherited
Plant ANatomical entity (PAN)microsporophyll0.1446Least InformativeInherited
Plant ANatomical entity (PAN)shoot axis0.1922Least InformativeInherited
Plant ANatomical entity (PAN)gamete1.662e-05InformativeDirect
Plant ANatomical entity (PAN)pollen tube cell0.0004188InformativeDirect
Plant ANatomical entity (PAN)primordium0.002516InformativeInherited
Plant ANatomical entity (PAN)portion of ground tissue0.006588InformativeInherited
Plant ANatomical entity (PAN)parenchyma cell2.926e-06Highly InformativeDirect
Plant ANatomical entity (PAN)vegetative shoot apex2.743e-05Highly InformativeDirect
Plant ANatomical entity (PAN)phyllome primordium3.442e-05Highly InformativeDirect
Plant ANatomical entity (PAN)mesophyll1Highly InformativeInherited
Plant structure DEvelopment stage (PDE)pollen development stage7.99e-05Moderately InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides9.401e-15Moderately InformativeDirect
Enzyme Commission (EC)Carbon-oxygen lyases0.1914Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Hexosyltransferases0.03405InformativeInherited
Enzyme Commission (EC)Intramolecular transferases (mutases)0.4834InformativeInherited
Enzyme Commission (EC)In phosphorous-containing anhydrides1InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides; catalyzing transmembrane movement of substances0Highly InformativeDirect
Enzyme Commission (EC)Phosphotransferases (phosphomutases)6.326e-05Highly InformativeDirect
Enzyme Commission (EC)Acting on ether bonds1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Biological processProtein transport1Moderately InformativeInherited
Biological processCalcium transport0Highly InformativeDirect
Biological processMethionine biosynthesis0Highly InformativeDirect
Biological processPotassium transport0Highly InformativeDirect
Biological processNucleotide metabolism7.027e-16Highly InformativeDirect
Biological processSodium transport5.58e-11Highly InformativeDirect
Biological processTranslocation4.728e-10Highly InformativeDirect
Biological processLipopolysaccharide biosynthesis1.665e-06Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus0.0002248Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentGolgi apparatus7.045e-07Moderately InformativeDirect
Cellular componentCell membrane0.000564Moderately InformativeDirect
Cellular componentPeriplasm0.0003721InformativeDirect
Cellular componentSarcoplasmic reticulum0Highly InformativeDirect
Coding sequence diversityAlternative splicing1.002e-09Least InformativeDirect
DiseaseDisease mutation7.134e-05Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionNucleotide-binding9.243e-08Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Molecular functionCalmodulin-binding0InformativeDirect
Molecular functionCopper0InformativeDirect
Molecular functionPotassium0InformativeDirect
Molecular functionSodium0InformativeDirect
Molecular functionCadmium0Highly InformativeDirect
Molecular functionSchiff base0Highly InformativeDirect
Molecular functionChloride4.855e-12Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationProtein phosphatase7.607e-09InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationNitration7.574e-05InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)amino-acid metabolism1.331e-10Least InformativeDirect
UniPathway (UP)biopolymer metabolism0.03178Least InformativeInherited
UniPathway (UP)carbohydrate metabolism0.2015Least InformativeInherited
UniPathway (UP)lipid metabolism0.398Least InformativeInherited
UniPathway (UP)organic acid metabolism0Moderately InformativeDirect
UniPathway (UP)proteinogenic amino-acid biosynthesis3.323e-14Moderately InformativeDirect
UniPathway (UP)nucleotide metabolism2.229e-10Moderately InformativeDirect
UniPathway (UP)glycan metabolism2.352e-08Moderately InformativeDirect
UniPathway (UP)cellular component biogenesis3.647e-06Moderately InformativeDirect
UniPathway (UP)biopolymer biosynthesis9.246e-06Moderately InformativeDirect
UniPathway (UP)membrane lipid metabolism1.4e-05Moderately InformativeDirect
UniPathway (UP)lipid biosynthesis0.0984Moderately InformativeInherited
UniPathway (UP)organic acid biosynthesis0InformativeDirect
UniPathway (UP)L-methionine biosynthesis0InformativeDirect
UniPathway (UP)nucleotide-sugar biosynthesis1.269e-15InformativeDirect
UniPathway (UP)lipopolysaccharide biosynthesis2.31e-09InformativeDirect
UniPathway (UP)LPS oligosaccharide biosynthesis0Highly InformativeDirect
UniPathway (UP)LPS core biosynthesis0Highly InformativeDirect
UniPathway (UP)lipooligosaccharide biosynthesis3.83e-08Highly InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 63 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a HAD-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 63 hidden Markov models representing the HAD-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]