SUPERFAMILY 1.75 HMM library and genome assignments server

Prim-pol domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Prim-pol domain [ 56746]
Superfamily:   Prim-pol domain [ 56747] (3)
Families:   PriA-like [ 56748] (2)
  Bifunctional DNA primase/polymerase N-terminal domain [ 103305]
  HP0184-like [ 143897]


Superfamily statistics
Genomes (1,029) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,798 3,365 6
Proteins 1,789 3,360 6


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) heterocycle metabolic process 0.0000001511 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 0.0000001764 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.0000003421 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.0000008339 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.0000034 Least Informative Direct
Biological Process (BP) biosynthetic process 0.0005011 Least Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 0.00002656 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.006558 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.006993 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.007408 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.01219 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.01783 Moderately Informative Inherited
Biological Process (BP) DNA metabolic process 0.000000000001939 Informative Direct
Biological Process (BP) DNA replication 0.000000115 Highly Informative Direct
Molecular Function (MF) transferase activity 0.0000001909 Least Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.000000002109 Moderately Informative Direct
Molecular Function (MF) nucleotidyltransferase activity 0 Informative Direct
Molecular Function (MF) RNA polymerase activity 0.001027 Highly Informative Inherited
Cellular Component (CC) intracellular organelle part 0.0004813 Least Informative Direct
Cellular Component (CC) protein complex 0.0004828 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.001892 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.01617 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.000002707 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.000004197 Moderately Informative Direct
Cellular Component (CC) chromosome 0.0000000672 Informative Direct
Cellular Component (CC) nuclear chromosome part 0.00001248 Highly Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDNA replication0InformativeDirect
Cellular componentDNA-directed RNA polymerase0Highly InformativeDirect
Cellular componentPrimosome0Highly InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Molecular functionManganese0Moderately InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationNucleotidyltransferase0Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Prim-pol domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the Prim-pol domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]