SUPERFAMILY 1.75 HMM library and genome assignments server


DNA/RNA polymerases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Multi-domain proteins (alpha and beta) [ 56572] (66)
Fold:   DNA/RNA polymerases [ 56671]
Superfamily:   DNA/RNA polymerases [ 56672] (6)
Families:   DNA polymerase I [ 56673] (4)
  Lesion bypass DNA polymerase (Y-family), catalytic domain [ 100888] (4)
  Reverse transcriptase [ 56686] (2)
  T7 RNA polymerase [ 56691]
  RNA-dependent RNA-polymerase [ 56694] (2)
  dsRNA phage RNA-dependent RNA-polymerase [ 64480]


Superfamily statistics
Genomes (3,141) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 59,282 293,130 164
Proteins 58,608 292,598 164


Functional annotation
General category Information
Detailed category DNA replication/repair

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)heterocycle metabolic process4.491e-070Least InformativeDirect
Biological Process (BP)cellular aromatic compound metabolic process5.046e-070Least InformativeDirect
Biological Process (BP)organic cyclic compound metabolic process2.008e-060Least InformativeDirect
Biological Process (BP)cellular macromolecule metabolic process3.556e-069.862e-09Least InformativeDirect
Biological Process (BP)nitrogen compound metabolic process1.529e-050Least InformativeDirect
Biological Process (BP)biosynthetic process0.0001990Least InformativeDirect
Biological Process (BP)single-organism cellular process0.067740.7966Least InformativeInherited
Biological Process (BP)response to stimulus0.23790Least InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process1.049e-060Moderately InformativeDirect
Biological Process (BP)cellular response to stress1.87e-052.78e-14Moderately InformativeDirect
Biological Process (BP)DNA metabolic process2.672e-120InformativeDirect
Biological Process (BP)response to DNA damage stimulus1.838e-080InformativeDirect
Biological Process (BP)DNA replication6.538e-100Highly InformativeDirect
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups1.914e-070Moderately InformativeDirect
Molecular Function (MF)nucleotidyltransferase activity7.543e-150InformativeDirect
Molecular Function (MF)DNA polymerase activity5.797e-080Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) heterocycle metabolic process 0 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 0 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 9.862e-09 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) biosynthetic process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.9506 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.2021 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.7966 Least Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cellular response to stress 2.78e-14 Moderately Informative Direct
Biological Process (BP) multi-organism process 0 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 9.66e-13 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 3.376e-12 Moderately Informative Direct
Biological Process (BP) regulation of localization 1.995e-11 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 5.755e-11 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 2.832e-09 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 5.891e-09 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.0005321 Moderately Informative Direct
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.001856 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.009372 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.04623 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.9833 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.05847 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.2995 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.3599 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.3895 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.7696 Moderately Informative Inherited
Biological Process (BP) DNA metabolic process 0 Informative Direct
Biological Process (BP) response to DNA damage stimulus 0 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0 Informative Direct
Biological Process (BP) proteolysis 0 Informative Direct
Biological Process (BP) negative regulation of signaling 0 Informative Direct
Biological Process (BP) regulation of immune response 0 Informative Direct
Biological Process (BP) regulation of immune effector process 0 Informative Direct
Biological Process (BP) negative regulation of cell communication 0 Informative Direct
Biological Process (BP) posttranscriptional regulation of gene expression 0 Informative Direct
Biological Process (BP) nucleic acid phosphodiester bond hydrolysis 0 Informative Direct
Biological Process (BP) regulation of intracellular transport 0 Informative Direct
Biological Process (BP) regulation of defense response 3.746e-15 Informative Direct
Biological Process (BP) negative regulation of gene expression 3.746e-15 Informative Direct
Biological Process (BP) mitochondrion organization 3.164e-07 Informative Direct
Biological Process (BP) defense response 0.0008799 Informative Direct
Biological Process (BP) cell cycle process 0.7462 Informative Inherited
Biological Process (BP) chromosome organization 0.05233 Informative Inherited
Biological Process (BP) DNA replication 0 Highly Informative Direct
Biological Process (BP) regulation of response to biotic stimulus 0 Highly Informative Direct
Biological Process (BP) negative regulation of immune system process 0 Highly Informative Direct
Biological Process (BP) regulation of multi-organism process 0 Highly Informative Direct
Biological Process (BP) modification of morphology or physiology of other organism involved in symbiotic interaction 0 Highly Informative Direct
Biological Process (BP) regulation of translation 0 Highly Informative Direct
Biological Process (BP) positive regulation of cellular catabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of autophagy 0 Highly Informative Direct
Biological Process (BP) multi-organism cellular process 0 Highly Informative Direct
Biological Process (BP) interaction with host 7.333e-15 Highly Informative Direct
Biological Process (BP) cell cycle phase 2.531e-06 Highly Informative Direct
Biological Process (BP) aging 0.000974 Highly Informative Direct
Biological Process (BP) double-strand break repair 1 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0.03538 Least Informative Inherited
Molecular Function (MF) binding 0.05 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) nucleic acid binding 3.062e-09 Moderately Informative Direct
Molecular Function (MF) nucleotidyltransferase activity 0 Informative Direct
Molecular Function (MF) nuclease activity 0 Informative Direct
Molecular Function (MF) peptidase activity 8.627e-13 Informative Direct
Molecular Function (MF) RNA binding 1.807e-08 Informative Direct
Molecular Function (MF) chromatin binding 1.097e-05 Informative Direct
Molecular Function (MF) DNA polymerase activity 0 Highly Informative Direct
Molecular Function (MF) DNA-directed RNA polymerase activity 0.5367 Highly Informative Inherited
Cellular Component (CC) intracellular organelle part 0 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 5.371e-05 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.1109 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.4777 Least Informative Inherited
Cellular Component (CC) nuclear part 0 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0.006887 Moderately Informative Inherited
Cellular Component (CC) mitochondrial part 0.06221 Moderately Informative Inherited
Cellular Component (CC) chromosome 0 Informative Direct
Cellular Component (CC) mitochondrial matrix 0.08045 Informative Inherited
Cellular Component (CC) replisome 0 Highly Informative Direct
Cellular Component (CC) DNA polymerase complex 0 Highly Informative Direct
Cellular Component (CC) nuclear chromosome part 2.593e-08 Highly Informative Direct
Cellular Component (CC) nuclear periphery 0.005604 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Nucleotidyltransferases0Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups1Least InformativeInherited
Enzyme Commission (EC)Endoribonucleases producing 5'-phosphomonoesters0Moderately InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0Moderately InformativeDirect
Enzyme Commission (EC)Cysteine endopeptidases0Moderately InformativeDirect
Enzyme Commission (EC)DNA-directed DNA polymerase0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases1Moderately InformativeInherited
Enzyme Commission (EC)Omega peptidases0.587Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)Methyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)mRNA (nucleoside-2'-O-)-methyltransferase0InformativeDirect
Enzyme Commission (EC)mRNA (guanine-N(7)-)-methyltransferase0InformativeDirect
Enzyme Commission (EC)Retroviral ribonuclease H0InformativeDirect
Enzyme Commission (EC)Flavivirin0InformativeDirect
Enzyme Commission (EC)RNA-directed DNA polymerase0InformativeDirect
Enzyme Commission (EC)Nucleoside-triphosphatase0InformativeDirect
Enzyme Commission (EC)Exoribonuclease H0InformativeDirect
Enzyme Commission (EC)Aspartic endopeptidases0InformativeDirect
Enzyme Commission (EC)RNA-directed RNA polymerase0InformativeDirect
Enzyme Commission (EC)Hepacivirin0Highly InformativeDirect
Enzyme Commission (EC)Picornain 3C0Highly InformativeDirect
Enzyme Commission (EC)Polynucleotide 5'-phosphatase0Highly InformativeDirect
Enzyme Commission (EC)Ribonuclease H2.098e-14Highly InformativeDirect
Enzyme Commission (EC)Picornain 2A2.396e-10Highly InformativeDirect
Enzyme Commission (EC)Nuclear-inclusion-a endopeptidase1.069e-09Highly InformativeDirect
Enzyme Commission (EC)Pestivirus NS3 polyprotein peptidase1.803e-07Highly InformativeDirect
Enzyme Commission (EC)Calicivirin2.573e-06Highly InformativeDirect
Enzyme Commission (EC)Helper-component proteinase3.673e-06Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.002448Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.004404Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.1912Least InformativeInherited
Mammalian Phenotype (MP)tumorigenesis0.0001003Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal leukopoiesis0.1378Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive immunity0.2002Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.313Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal chromosome stability0.002558InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.01982InformativeInherited
Mammalian Phenotype (MP)increased malignant tumor incidence0.2026InformativeInherited
Mammalian Phenotype (MP)chromosomal instability0.0009811Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.0006634Least InformativeDirect
Worm Phenotype (WP)cell organization biogenesis variant0.02369Moderately InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.02455Moderately InformativeInherited
Worm Phenotype (WP)embryonic cell organization biogenesis variant0.001572InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)chromosome/plasmid maintenance0.1426InformativeInherited
Yeast Phenotype (YP)mutation frequency1.52e-05Highly InformativeDirect
Yeast Phenotype (YP)UV resistance0.000913Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)radiation sensitive8.823e-08InformativeDirect
Fly Phenotype (FP)stress response defective0.001256InformativeInherited
Fly Phenotype (FP)DNA repair defective2.179e-07Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0Least InformativeDirect
Zebrafish Anatomy (ZA)head0Least InformativeDirect
Zebrafish Anatomy (ZA)multi-tissue structure0Least InformativeDirect
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)eye0Moderately InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)0 seed germination stage4.208e-08InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)RNA-directed RNA polymerase0InformativeDirect
Enzyme Commission (EC)DNA-directed DNA polymerase0InformativeDirect
Enzyme Commission (EC)Exoribonucleases producing 5'-phosphomonoesters0InformativeDirect
Enzyme Commission (EC)Endoribonucleases producing 5'-phosphomonoesters0InformativeDirect
Enzyme Commission (EC)Cysteine endopeptidases0InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides0InformativeDirect
Enzyme Commission (EC)RNA helicase0InformativeDirect
Enzyme Commission (EC)Omega peptidases0.7355InformativeInherited
Enzyme Commission (EC)Serine endopeptidases1InformativeInherited
Enzyme Commission (EC)mRNA (guanine-N(7)-)-methyltransferase0Highly InformativeDirect
Enzyme Commission (EC)mRNA (nucleoside-2'-O)-methyltransferase0Highly InformativeDirect
Enzyme Commission (EC)RNA-directed DNA polymerase0Highly InformativeDirect
Enzyme Commission (EC)Exoribonuclease H0Highly InformativeDirect
Enzyme Commission (EC)Retroviral ribonuclease H0Highly InformativeDirect
Enzyme Commission (EC)Polynucleotide 5'-phosphatase0Highly InformativeDirect
Enzyme Commission (EC)Flavivirin0Highly InformativeDirect
Enzyme Commission (EC)HIV-1 retropepsin0Highly InformativeDirect
Enzyme Commission (EC)Nucleoside-triphosphate phosphatase0Highly InformativeDirect
Enzyme Commission (EC)Picornain 3C2.419e-16Highly InformativeDirect
Enzyme Commission (EC)Picornain 2A4.118e-09Highly InformativeDirect
Enzyme Commission (EC)HIV-2 retropepsin2.263e-05Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processDNA damage0Moderately InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Biological processHost-virus interaction0Moderately InformativeDirect
Biological processApoptosis1.021e-09Moderately InformativeDirect
Biological processDNA recombination0InformativeDirect
Biological processDNA replication0InformativeDirect
Biological processViral RNA replication0InformativeDirect
Biological processViral immunoevasion0InformativeDirect
Biological processVirus entry into host cell0InformativeDirect
Biological processHost gene expression shutoff by virus0InformativeDirect
Biological processDNA integration0Highly InformativeDirect
Biological processmRNA capping0Highly InformativeDirect
Biological processActivation of host autophagy by virus0Highly InformativeDirect
Biological processModulation of host ubiquitin pathway by viral deubiquitinase0Highly InformativeDirect
Biological processFusion of virus membrane with host endosomal membrane0Highly InformativeDirect
Biological processViral genome integration0Highly InformativeDirect
Biological processVirus exit from host cell0Highly InformativeDirect
Biological processDNA synthesis4.14e-14Highly InformativeDirect
Biological processModulation of host cell apoptosis by virus3.234e-13Highly InformativeDirect
Biological processVirus endocytosis by host4.666e-09Highly InformativeDirect
Biological processIntron homing4.971e-08Highly InformativeDirect
Biological processDecay of host mRNAs by virus1.356e-05Highly InformativeDirect
Biological processSOS response1Highly InformativeInherited
Cellular componentMembrane0Least InformativeDirect
Cellular componentMitochondrion0.0965Moderately InformativeInherited
Cellular componentCapsid protein0InformativeDirect
Cellular componentHost cytoplasm0InformativeDirect
Cellular componentHost membrane0InformativeDirect
Cellular componentHost nucleus0InformativeDirect
Cellular componentChromosome0.353InformativeInherited
Cellular componentHost cytoplasmic vesicle0Highly InformativeDirect
Cellular componentHost endoplasmic reticulum0Highly InformativeDirect
Cellular componentHost endosome0Highly InformativeDirect
Cellular componentTelomere2.214e-07Highly InformativeDirect
Cellular componentDNA-directed RNA polymerase0.0009476Highly InformativeDirect
Coding sequence diversityRibosomal frameshifting0Moderately InformativeDirect
Coding sequence diversityAlternative promoter usage0.0009836Moderately InformativeDirect
Coding sequence diversityRNA suppression of termination0InformativeDirect
Developmental stageEarly protein3.215e-05Least InformativeDirect
DiseaseAIDS0Moderately InformativeDirect
DiseaseOncogene0Moderately InformativeDirect
DomainTransmembrane0.1445Least InformativeInherited
DomainZinc-finger0Moderately InformativeDirect
DomainSH3-binding0InformativeDirect
Molecular functionDNA-binding0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionNucleotide-binding1.149e-15Least InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Molecular functionRNA-binding0Moderately InformativeDirect
Molecular functionViral nucleoprotein0Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationNuclease0Moderately InformativeDirect
Post-translational modificationNucleotidyltransferase0Moderately InformativeDirect
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationDNA-directed DNA polymerase0InformativeDirect
Post-translational modificationHelicase0InformativeDirect
Post-translational modificationIon channel0InformativeDirect
Post-translational modificationThiol protease0InformativeDirect
Post-translational modificationEndonuclease1.547e-13InformativeDirect
Post-translational modificationAspartyl protease0Highly InformativeDirect
Post-translational modificationRNA-directed DNA polymerase0Highly InformativeDirect
Post-translational modificationRNA-directed RNA polymerase0Highly InformativeDirect
Post-translational modificationViral ion channel0Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues0Moderately InformativeDirect
Post-translational modificationUbl conjugation4.617e-16Moderately InformativeDirect
Post-translational modificationMyristate0InformativeDirect
Post-translational modificationAutocatalytic cleavage0.2308InformativeInherited
Post-translational modificationCovalent protein-RNA linkage0Highly InformativeDirect
Post-translational modificationProtein splicing2.332e-14Highly InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 34 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a DNA/RNA polymerases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 34 hidden Markov models representing the DNA/RNA polymerases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]