SUPERFAMILY 1.75 HMM library and genome assignments server


Serpins superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Multi-domain proteins (alpha and beta) [ 56572] (66)
Fold:   Serpins [ 56573]
Superfamily:   Serpins [ 56574]
Families:   Serpins [ 56575] (16)


Superfamily statistics
Genomes (475) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 5,387 7,957 63
Proteins 5,087 7,757 63


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of metabolic process1.265e-121.758e-08Least InformativeDirect
Biological Process (BP)response to stimulus1.966e-050.0001058Least InformativeDirect
Biological Process (BP)developmental process0.00640.7423Least InformativeInherited
Biological Process (BP)multicellular organismal process6.394e-090.003838Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)localization11Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.86021Least InformativeInherited
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)single-organism cellular process0.28371Least InformativeInherited
Biological Process (BP)protein metabolic process0.99971Least InformativeInherited
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process11Least InformativeInherited
Biological Process (BP)reproduction1.76e-125.161e-07Moderately InformativeDirect
Biological Process (BP)response to endogenous stimulus5.516e-081.4e-08Moderately InformativeDirect
Biological Process (BP)response to organic substance3.202e-073.072e-07Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process1.8e-053.017e-05Moderately InformativeDirect
Biological Process (BP)regulation of catalytic activity0.00019961.032e-08Moderately InformativeDirect
Biological Process (BP)regulation of protein metabolic process4.844e-150Moderately InformativeDirect
Biological Process (BP)multi-organism process1.223e-071.379e-06Moderately InformativeDirect
Biological Process (BP)response to oxygen-containing compound5.115e-087.361e-09Moderately InformativeDirect
Biological Process (BP)cellular response to chemical stimulus11Moderately InformativeInherited
Biological Process (BP)regulation of gene expression11Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.024940.7936Moderately InformativeInherited
Biological Process (BP)gene expression0.40271Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.16370.231Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.6460.8916Moderately InformativeInherited
Biological Process (BP)organelle organization11Moderately InformativeInherited
Biological Process (BP)cellular localization0.74770.9829Moderately InformativeInherited
Biological Process (BP)immune system process0.00037160.006461Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.056260.4549Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.30361Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process8.289e-050.001202Moderately InformativeInherited
Biological Process (BP)signal transduction10.9879Moderately InformativeInherited
Biological Process (BP)carbohydrate metabolic process0.57550.7928Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.95681Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process0.47151Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process0.9371Moderately InformativeInherited
Biological Process (BP)tissue development0.062810.3104Moderately InformativeInherited
Biological Process (BP)organ development0.29470.5058Moderately InformativeInherited
Biological Process (BP)cell differentiation0.012780.9685Moderately InformativeInherited
Biological Process (BP)defense response0.00053220.0008127InformativeDirect
Biological Process (BP)response to wounding0.00087788.299e-05InformativeDirect
Biological Process (BP)response to hormone stimulus4.425e-091.332e-11InformativeDirect
Biological Process (BP)response to organonitrogen compound1.748e-091.137e-10InformativeDirect
Biological Process (BP)negative regulation of cell communication0.00063270.0008884InformativeDirect
Biological Process (BP)secretion by cell0.00088830.000318InformativeDirect
Biological Process (BP)response to cytokine stimulus1.064e-120InformativeDirect
Biological Process (BP)regulation of cell proliferation0.00016552.077e-06InformativeDirect
Biological Process (BP)negative regulation of catalytic activity00InformativeDirect
Biological Process (BP)regulation of body fluid levels0.00019155.029e-05InformativeDirect
Biological Process (BP)negative regulation of protein metabolic process2.874e-075.424e-14InformativeDirect
Biological Process (BP)regulation of peptidase activity00InformativeDirect
Biological Process (BP)response to organic cyclic compound0.84311InformativeInherited
Biological Process (BP)response to lipid0.7380.8701InformativeInherited
Biological Process (BP)cellular response to endogenous stimulus11InformativeInherited
Biological Process (BP)organ morphogenesis0.027170.363InformativeInherited
Biological Process (BP)negative regulation of signaling0.0044960.01727InformativeInherited
Biological Process (BP)negative regulation of response to stimulus0.0028545.15e-06InformativeInherited
Biological Process (BP)regulation of response to external stimulus0.0088251.982e-07InformativeInherited
Biological Process (BP)immune response0.0083710.004205InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.54690.4122InformativeInherited
Biological Process (BP)negative regulation of developmental process0.59111InformativeInherited
Biological Process (BP)response to other organism0.0011540.001434InformativeInherited
Biological Process (BP)humoral immune response0.00089543.418e-07Highly InformativeDirect
Biological Process (BP)hemostasis3.063e-068.322e-07Highly InformativeDirect
Biological Process (BP)response to fungus0.00044211.308e-06Highly InformativeDirect
Biological Process (BP)negative regulation of endopeptidase activity1.317e-051.125e-12Highly InformativeDirect
Biological Process (BP)vesicle organization1.894e-050.0001196Highly InformativeDirect
Biological Process (BP)regulation of proteolysis9.967e-110Highly InformativeDirect
Biological Process (BP)extracellular matrix organization3.179e-109.436e-10Highly InformativeDirect
Biological Process (BP)negative regulation of hormone metabolic process4.13e-099.597e-13Highly InformativeDirect
Biological Process (BP)response to peptide hormone stimulus9.963e-093.196e-11Highly InformativeDirect
Biological Process (BP)multicellular organismal metabolic process1.654e-094.335e-08Highly InformativeDirect
Biological Process (BP)regulation of angiogenesis1.835e-053.409e-07Highly InformativeDirect
Biological Process (BP)coagulation2.419e-057.162e-07Highly InformativeDirect
Biological Process (BP)regulation of coagulation1.49e-092.004e-12Highly InformativeDirect
Biological Process (BP)regulation of wound healing2.828e-098.624e-08Highly InformativeDirect
Biological Process (BP)connective tissue development0.00013210.0005018Highly InformativeDirect
Biological Process (BP)regulation of protein processing4.243e-120Highly InformativeDirect
Biological Process (BP)cellular response to steroid hormone stimulus0.00047374.355e-05Highly InformativeDirect
Biological Process (BP)regulation of hemostasis1.339e-082.291e-11Highly InformativeDirect
Biological Process (BP)negative regulation of multicellular organismal process0.11780.09452Highly InformativeInherited
Biological Process (BP)negative regulation of cell proliferation0.13310.1272Highly InformativeInherited
Biological Process (BP)regulation of reproductive process0.035130.08737Highly InformativeInherited
Biological Process (BP)skeletal system development0.0016730.01891Highly InformativeInherited
Biological Process (BP)protein glycosylation0.00015820.00177Highly InformativeInherited
Molecular Function (MF)binding5.223e-080.01047Least InformativeInherited
Molecular Function (MF)enzyme regulator activity00Moderately InformativeDirect
Molecular Function (MF)anion binding0.55680.493Moderately InformativeInherited
Molecular Function (MF)enzyme inhibitor activity00InformativeDirect
Molecular Function (MF)lipid binding9.006e-074.16e-08InformativeDirect
Molecular Function (MF)peptidase regulator activity00InformativeDirect
Molecular Function (MF)carbohydrate derivative binding0.024030.0041InformativeInherited
Molecular Function (MF)sulfur compound binding0.019050.001586InformativeInherited
Molecular Function (MF)enzyme binding0.017150.04883InformativeInherited
Molecular Function (MF)serine-type endopeptidase inhibitor activity00Highly InformativeDirect
Molecular Function (MF)steroid binding5.177e-150Highly InformativeDirect
Molecular Function (MF)heparin binding0.00075045.828e-05Highly InformativeDirect
Molecular Function (MF)unfolded protein binding3.385e-064.978e-06Highly InformativeDirect
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)intracellular organelle part11Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)vesicle6.259e-139.033e-15Moderately InformativeDirect
Cellular Component (CC)extracellular region part00Moderately InformativeDirect
Cellular Component (CC)extracellular space3.635e-081.597e-15InformativeDirect
Cellular Component (CC)secretory granule0.00046052.438e-06InformativeDirect
Cellular Component (CC)extracellular membrane-bounded organelle1.52e-095.373e-14InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of metabolic process 1.758e-08 Least Informative Direct
Biological Process (BP) response to stimulus 0.0001058 Least Informative Direct
Biological Process (BP) developmental process 0.7423 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.003838 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) reproduction 5.161e-07 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 1.4e-08 Moderately Informative Direct
Biological Process (BP) response to organic substance 3.072e-07 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 3.017e-05 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 1.032e-08 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0 Moderately Informative Direct
Biological Process (BP) multi-organism process 1.379e-06 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 7.361e-09 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.7936 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.231 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.8916 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.9829 Moderately Informative Inherited
Biological Process (BP) immune system process 0.006461 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.4549 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.001202 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.9879 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.7928 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) system process 0.2864 Moderately Informative Inherited
Biological Process (BP) tissue development 0.3104 Moderately Informative Inherited
Biological Process (BP) organ development 0.5058 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.9685 Moderately Informative Inherited
Biological Process (BP) defense response 0.0008127 Informative Direct
Biological Process (BP) blood circulation 0.0003359 Informative Direct
Biological Process (BP) response to wounding 8.299e-05 Informative Direct
Biological Process (BP) response to hormone stimulus 1.332e-11 Informative Direct
Biological Process (BP) response to organonitrogen compound 1.137e-10 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.0008884 Informative Direct
Biological Process (BP) regulation of response to external stimulus 1.982e-07 Informative Direct
Biological Process (BP) secretion by cell 0.000318 Informative Direct
Biological Process (BP) response to cytokine stimulus 0 Informative Direct
Biological Process (BP) regulation of cell proliferation 2.077e-06 Informative Direct
Biological Process (BP) negative regulation of catalytic activity 0 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 5.15e-06 Informative Direct
Biological Process (BP) regulation of body fluid levels 5.029e-05 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 5.457e-06 Informative Direct
Biological Process (BP) negative regulation of protein metabolic process 5.424e-14 Informative Direct
Biological Process (BP) regulation of peptidase activity 0 Informative Direct
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) response to lipid 0.8701 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 1 Informative Inherited
Biological Process (BP) organ morphogenesis 0.363 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.01727 Informative Inherited
Biological Process (BP) regulation of defense response 0.5215 Informative Inherited
Biological Process (BP) immune response 0.004205 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.4122 Informative Inherited
Biological Process (BP) negative regulation of developmental process 1 Informative Inherited
Biological Process (BP) regulation of ion transport 0.01079 Informative Inherited
Biological Process (BP) response to other organism 0.001434 Informative Inherited
Biological Process (BP) regulation of immune response 0.5049 Informative Inherited
Biological Process (BP) regulation of humoral immune response 0.0001734 Highly Informative Direct
Biological Process (BP) vascular process in circulatory system 0.0003731 Highly Informative Direct
Biological Process (BP) humoral immune response 3.418e-07 Highly Informative Direct
Biological Process (BP) hemostasis 8.322e-07 Highly Informative Direct
Biological Process (BP) regulation of blood pressure 4.564e-05 Highly Informative Direct
Biological Process (BP) response to fungus 1.308e-06 Highly Informative Direct
Biological Process (BP) negative regulation of endopeptidase activity 1.125e-12 Highly Informative Direct
Biological Process (BP) vesicle organization 0.0001196 Highly Informative Direct
Biological Process (BP) regulation of proteolysis 0 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 9.436e-10 Highly Informative Direct
Biological Process (BP) negative regulation of hormone metabolic process 9.597e-13 Highly Informative Direct
Biological Process (BP) response to peptide hormone stimulus 3.196e-11 Highly Informative Direct
Biological Process (BP) multicellular organismal metabolic process 4.335e-08 Highly Informative Direct
Biological Process (BP) regulation of angiogenesis 3.409e-07 Highly Informative Direct
Biological Process (BP) coagulation 7.162e-07 Highly Informative Direct
Biological Process (BP) regulation of coagulation 2.004e-12 Highly Informative Direct
Biological Process (BP) regulation of wound healing 8.624e-08 Highly Informative Direct
Biological Process (BP) connective tissue development 0.0005018 Highly Informative Direct
Biological Process (BP) regulation of protein processing 0 Highly Informative Direct
Biological Process (BP) cellular response to steroid hormone stimulus 4.355e-05 Highly Informative Direct
Biological Process (BP) regulation of hemostasis 2.291e-11 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.09452 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 0.1272 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.08737 Highly Informative Inherited
Biological Process (BP) skeletal system development 0.01891 Highly Informative Inherited
Biological Process (BP) regulation of innate immune response 0.09261 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.02861 Highly Informative Inherited
Biological Process (BP) protein glycosylation 0.00177 Highly Informative Inherited
Molecular Function (MF) binding 0.01047 Least Informative Inherited
Molecular Function (MF) enzyme regulator activity 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.493 Moderately Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 0 Informative Direct
Molecular Function (MF) lipid binding 4.16e-08 Informative Direct
Molecular Function (MF) peptidase regulator activity 0 Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.0041 Informative Inherited
Molecular Function (MF) sulfur compound binding 0.001586 Informative Inherited
Molecular Function (MF) enzyme binding 0.04883 Informative Inherited
Molecular Function (MF) serine-type endopeptidase inhibitor activity 0 Highly Informative Direct
Molecular Function (MF) steroid binding 0 Highly Informative Direct
Molecular Function (MF) heparin binding 5.828e-05 Highly Informative Direct
Molecular Function (MF) unfolded protein binding 4.978e-06 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) vesicle 9.033e-15 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) extracellular space 1.597e-15 Informative Direct
Cellular Component (CC) secretory granule 2.438e-06 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 5.373e-14 Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.1384Least InformativeInherited
Disease Ontology (DO)urinary system disease0.2093Moderately InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.4076Moderately InformativeInherited
Disease Ontology (DO)kidney failure0.02898InformativeInherited

Document: DO annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)pericellular component development variant2.613e-09Moderately InformativeDirect
Worm Phenotype (WP)basement membrane remodeling variant7.141e-10InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)NF stage0.004273Least InformativeInherited
Xenopus DEvelopment stage (XDE)tadpole stage3.197e-06InformativeDirect
Xenopus DEvelopment stage (XDE)NF stage 531.239e-05Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processHost-virus interaction0.04221Moderately InformativeInherited
Biological processHemostasis0InformativeDirect
Biological processAcute phase0Highly InformativeDirect
Biological processBlood coagulation0Highly InformativeDirect
Biological processModulation of host cell apoptosis by virus1.263e-10Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.0001197Moderately InformativeDirect
Cellular componentHost cytoplasm4.239e-08InformativeDirect
Coding sequence diversityPolymorphism8.38e-07Moderately InformativeDirect
DomainSignal0Least InformativeDirect
Molecular functionHeparin-binding0InformativeDirect
Molecular functionLipid-binding6.425e-09InformativeDirect
Molecular functionSteroid-binding0Highly InformativeDirect
Post-translational modificationProtease inhibitor0InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationSulfation6.226e-07InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000215 SSF56574 Protein matches
Abstract

Serpins (SERine Proteinase INhibitors) [PubMed14705960, PubMed2690952, PubMed8417965] belong to MEROPS inhibitor family I4, clan ID. Serpins are proteins that are primarily known as irreversible serine protease inhibitors active against S1 , S8 and C14 peptidases. There are both extra- and intra-cellular serpins, which are found in all groups of organisms with the notable exception of fungi [PubMed11116082, PubMed12411597]. In contrast to "rigid" proteinase inhibitors, such as those of the Kunitz or Kazal families, the serpins are metastable proteins (active-state proteins) which interact with their substrate and irreversibly trap the acyl intermediate as a result of a major conformational change [PubMed11116079]; they are best described as suicide substrate inhibitors. The common structure of these proteins is a multi-domain fold containing a bundle of 8 or 9 alpha helices and a beta sandwich formed by 3 beta sheets. The reactive centre loop (RCL) is found in the C-terminal part of these proteins.

Serpins and their homologues are a group of high molecular weight (40 to 50 kDa) structurally related proteins involved in a number of fundamental biological processes such as blood coagulation, complement activation, fibrinolysis, angiogenesis, inflammation, tumour suppression and hormone transport. All known serpins have been classified into 16 clades and 10 orphan sequences; the vertebrate serpins can be conveniently classified into six sub-groups [PubMed11116082]. In human plasma they represent approximately 2% of the total protein, of which 70% is alpha-1-antitrypsin. On the basis of strong sequence similarities, a number of proteins with no known inhibitory activity also belong to this family, these include: angiotensinogen, corticosteroid-binding globulin and thyroxin-binding globulin [PubMed12824063].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 17 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Serpins domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 17 hidden Markov models representing the Serpins superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]