SUPERFAMILY 1.75 HMM library and genome assignments server


Serpins superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Multi-domain proteins (alpha and beta) [ 56572] (66)
Fold:   Serpins [ 56573]
Superfamily:   Serpins [ 56574]
Families:   Serpins [ 56575] (16)


Superfamily statistics
Genomes (475) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 5,387 7,957 63
Proteins 5,087 7,757 63


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of metabolic process1.359e-121.977e-08Least InformativeDirect
Biological Process (BP)response to stimulus1.363e-056.857e-05Least InformativeDirect
Biological Process (BP)developmental process0.0058850.714Least InformativeInherited
Biological Process (BP)multicellular organismal process5.352e-090.003076Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)localization11Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.84461Least InformativeInherited
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)single-organism cellular process0.25511Least InformativeInherited
Biological Process (BP)protein metabolic process0.9951Least InformativeInherited
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process11Least InformativeInherited
Biological Process (BP)reproduction1.566e-124.289e-07Moderately InformativeDirect
Biological Process (BP)response to endogenous stimulus5.775e-081.448e-08Moderately InformativeDirect
Biological Process (BP)response to organic substance2.496e-072.313e-07Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process1.936e-052.921e-05Moderately InformativeDirect
Biological Process (BP)regulation of catalytic activity0.00021929.896e-09Moderately InformativeDirect
Biological Process (BP)regulation of protein metabolic process6.509e-150Moderately InformativeDirect
Biological Process (BP)multi-organism process7.757e-088.769e-07Moderately InformativeDirect
Biological Process (BP)response to oxygen-containing compound5.82e-087.449e-09Moderately InformativeDirect
Biological Process (BP)cellular response to chemical stimulus11Moderately InformativeInherited
Biological Process (BP)regulation of gene expression11Moderately InformativeInherited
Biological Process (BP)gene expression0.39671Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.16680.2312Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.64750.8937Moderately InformativeInherited
Biological Process (BP)organelle organization11Moderately InformativeInherited
Biological Process (BP)cellular localization0.73790.9718Moderately InformativeInherited
Biological Process (BP)immune system process0.00034350.005799Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.05910.4464Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.31941Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process8.462e-050.001133Moderately InformativeInherited
Biological Process (BP)signal transduction10.9899Moderately InformativeInherited
Biological Process (BP)carbohydrate metabolic process0.55790.7793Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.95171Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process0.4551Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process0.91521Moderately InformativeInherited
Biological Process (BP)tissue development0.062840.2977Moderately InformativeInherited
Biological Process (BP)organ development0.29360.4848Moderately InformativeInherited
Biological Process (BP)cell differentiation0.012220.9564Moderately InformativeInherited
Biological Process (BP)defense response0.00057280.0008497InformativeDirect
Biological Process (BP)response to wounding0.00095648.789e-05InformativeDirect
Biological Process (BP)response to hormone stimulus5.352e-091.479e-11InformativeDirect
Biological Process (BP)response to organonitrogen compound2.057e-091.243e-10InformativeDirect
Biological Process (BP)negative regulation of cell communication0.00067880.0009282InformativeDirect
Biological Process (BP)secretion by cell0.0008980.0002904InformativeDirect
Biological Process (BP)response to cytokine stimulus6.595e-130InformativeDirect
Biological Process (BP)negative regulation of catalytic activity00InformativeDirect
Biological Process (BP)regulation of body fluid levels0.0001964.707e-05InformativeDirect
Biological Process (BP)negative regulation of protein metabolic process3.029e-075.763e-14InformativeDirect
Biological Process (BP)regulation of peptidase activity00InformativeDirect
Biological Process (BP)response to organic cyclic compound0.84911InformativeInherited
Biological Process (BP)response to lipid0.74530.8695InformativeInherited
Biological Process (BP)cellular response to endogenous stimulus11InformativeInherited
Biological Process (BP)organ morphogenesis0.027280.3527InformativeInherited
Biological Process (BP)negative regulation of signaling0.0048280.01793InformativeInherited
Biological Process (BP)negative regulation of response to stimulus0.0026275.239e-06InformativeInherited
Biological Process (BP)regulation of response to external stimulus0.0091992.046e-07InformativeInherited
Biological Process (BP)immune response0.0087970.0043InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.56010.4078InformativeInherited
Biological Process (BP)negative regulation of developmental process0.59531InformativeInherited
Biological Process (BP)response to other organism0.0011360.001524InformativeInherited
Biological Process (BP)humoral immune response0.00091043.501e-07Highly InformativeDirect
Biological Process (BP)hemostasis2.98e-067.761e-07Highly InformativeDirect
Biological Process (BP)response to fungus0.00053821.511e-06Highly InformativeDirect
Biological Process (BP)negative regulation of endopeptidase activity1.325e-051.128e-12Highly InformativeDirect
Biological Process (BP)vesicle organization1.849e-050.0001097Highly InformativeDirect
Biological Process (BP)regulation of proteolysis8.83e-110Highly InformativeDirect
Biological Process (BP)extracellular matrix organization3.07e-108.538e-10Highly InformativeDirect
Biological Process (BP)negative regulation of hormone metabolic process4.385e-091.004e-12Highly InformativeDirect
Biological Process (BP)response to peptide hormone stimulus1.008e-083.214e-11Highly InformativeDirect
Biological Process (BP)multicellular organismal metabolic process1.617e-094.114e-08Highly InformativeDirect
Biological Process (BP)regulation of angiogenesis1.725e-053.653e-07Highly InformativeDirect
Biological Process (BP)coagulation2.431e-056.673e-07Highly InformativeDirect
Biological Process (BP)regulation of coagulation1.552e-092.196e-12Highly InformativeDirect
Biological Process (BP)regulation of wound healing3.253e-099.676e-08Highly InformativeDirect
Biological Process (BP)connective tissue development0.00013280.0004735Highly InformativeDirect
Biological Process (BP)regulation of protein processing4.756e-120Highly InformativeDirect
Biological Process (BP)cellular response to steroid hormone stimulus0.00047484.408e-05Highly InformativeDirect
Biological Process (BP)regulation of hemostasis1.391e-082.5e-11Highly InformativeDirect
Biological Process (BP)negative regulation of multicellular organismal process0.12060.09584Highly InformativeInherited
Biological Process (BP)negative regulation of cell proliferation0.13410.1286Highly InformativeInherited
Biological Process (BP)regulation of reproductive process0.034820.0869Highly InformativeInherited
Biological Process (BP)skeletal system development0.0016830.0188Highly InformativeInherited
Biological Process (BP)protein glycosylation0.00014810.00174Highly InformativeInherited
Molecular Function (MF)binding2.445e-080.007262Least InformativeInherited
Molecular Function (MF)enzyme regulator activity00Moderately InformativeDirect
Molecular Function (MF)anion binding0.53340.4741Moderately InformativeInherited
Molecular Function (MF)enzyme inhibitor activity00InformativeDirect
Molecular Function (MF)lipid binding1.016e-064.247e-08InformativeDirect
Molecular Function (MF)peptidase regulator activity00InformativeDirect
Molecular Function (MF)carbohydrate derivative binding0.024980.004137InformativeInherited
Molecular Function (MF)sulfur compound binding0.019860.001533InformativeInherited
Molecular Function (MF)enzyme binding0.017770.04809InformativeInherited
Molecular Function (MF)serine-type endopeptidase inhibitor activity00Highly InformativeDirect
Molecular Function (MF)steroid binding5.176e-150Highly InformativeDirect
Molecular Function (MF)heparin binding0.00073755.5e-05Highly InformativeDirect
Molecular Function (MF)unfolded protein binding3.525e-065.706e-06Highly InformativeDirect
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)intracellular organelle part11Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)vesicle5.412e-136.169e-15Moderately InformativeDirect
Cellular Component (CC)extracellular region part00Moderately InformativeDirect
Cellular Component (CC)extracellular space3.789e-081.61e-15InformativeDirect
Cellular Component (CC)secretory granule0.00046262.45e-06InformativeDirect
Cellular Component (CC)extracellular membrane-bounded organelle1.39e-094.473e-14InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of metabolic process 1.977e-08 Least Informative Direct
Biological Process (BP) response to stimulus 6.857e-05 Least Informative Direct
Biological Process (BP) developmental process 0.714 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.003076 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) reproduction 4.289e-07 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 1.448e-08 Moderately Informative Direct
Biological Process (BP) response to organic substance 2.313e-07 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 2.921e-05 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 9.896e-09 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0 Moderately Informative Direct
Biological Process (BP) multi-organism process 8.769e-07 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 7.449e-09 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.2312 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.8937 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.9718 Moderately Informative Inherited
Biological Process (BP) immune system process 0.005799 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.4464 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.001133 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.9899 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.7793 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) system process 0.2756 Moderately Informative Inherited
Biological Process (BP) tissue development 0.2977 Moderately Informative Inherited
Biological Process (BP) organ development 0.4848 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.9564 Moderately Informative Inherited
Biological Process (BP) defense response 0.0008497 Informative Direct
Biological Process (BP) blood circulation 0.0003186 Informative Direct
Biological Process (BP) response to wounding 8.789e-05 Informative Direct
Biological Process (BP) response to hormone stimulus 1.479e-11 Informative Direct
Biological Process (BP) response to organonitrogen compound 1.243e-10 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.0009282 Informative Direct
Biological Process (BP) regulation of response to external stimulus 2.046e-07 Informative Direct
Biological Process (BP) secretion by cell 0.0002904 Informative Direct
Biological Process (BP) response to cytokine stimulus 0 Informative Direct
Biological Process (BP) negative regulation of catalytic activity 0 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 5.239e-06 Informative Direct
Biological Process (BP) regulation of body fluid levels 4.707e-05 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 4.876e-06 Informative Direct
Biological Process (BP) negative regulation of protein metabolic process 5.763e-14 Informative Direct
Biological Process (BP) regulation of peptidase activity 0 Informative Direct
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) response to lipid 0.8695 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 1 Informative Inherited
Biological Process (BP) organ morphogenesis 0.3527 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.01793 Informative Inherited
Biological Process (BP) regulation of defense response 0.5202 Informative Inherited
Biological Process (BP) immune response 0.0043 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.4078 Informative Inherited
Biological Process (BP) negative regulation of developmental process 1 Informative Inherited
Biological Process (BP) regulation of ion transport 0.01075 Informative Inherited
Biological Process (BP) response to other organism 0.001524 Informative Inherited
Biological Process (BP) regulation of immune response 0.5011 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.01356 Informative Inherited
Biological Process (BP) regulation of humoral immune response 0.0001785 Highly Informative Direct
Biological Process (BP) vascular process in circulatory system 0.0003731 Highly Informative Direct
Biological Process (BP) humoral immune response 3.501e-07 Highly Informative Direct
Biological Process (BP) hemostasis 7.761e-07 Highly Informative Direct
Biological Process (BP) regulation of blood pressure 4.342e-05 Highly Informative Direct
Biological Process (BP) response to fungus 1.511e-06 Highly Informative Direct
Biological Process (BP) negative regulation of endopeptidase activity 1.128e-12 Highly Informative Direct
Biological Process (BP) vesicle organization 0.0001097 Highly Informative Direct
Biological Process (BP) regulation of proteolysis 0 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 8.538e-10 Highly Informative Direct
Biological Process (BP) negative regulation of hormone metabolic process 1.004e-12 Highly Informative Direct
Biological Process (BP) response to peptide hormone stimulus 3.214e-11 Highly Informative Direct
Biological Process (BP) multicellular organismal metabolic process 4.114e-08 Highly Informative Direct
Biological Process (BP) regulation of angiogenesis 3.653e-07 Highly Informative Direct
Biological Process (BP) coagulation 6.673e-07 Highly Informative Direct
Biological Process (BP) regulation of coagulation 2.196e-12 Highly Informative Direct
Biological Process (BP) regulation of wound healing 9.676e-08 Highly Informative Direct
Biological Process (BP) connective tissue development 0.0004735 Highly Informative Direct
Biological Process (BP) regulation of protein processing 0 Highly Informative Direct
Biological Process (BP) cellular response to steroid hormone stimulus 4.408e-05 Highly Informative Direct
Biological Process (BP) regulation of hemostasis 2.5e-11 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.09584 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 0.1286 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.0869 Highly Informative Inherited
Biological Process (BP) skeletal system development 0.0188 Highly Informative Inherited
Biological Process (BP) regulation of innate immune response 0.0949 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.0278 Highly Informative Inherited
Biological Process (BP) protein glycosylation 0.00174 Highly Informative Inherited
Molecular Function (MF) binding 0.007262 Least Informative Inherited
Molecular Function (MF) enzyme regulator activity 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.4741 Moderately Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 0 Informative Direct
Molecular Function (MF) lipid binding 4.247e-08 Informative Direct
Molecular Function (MF) peptidase regulator activity 0 Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.004137 Informative Inherited
Molecular Function (MF) sulfur compound binding 0.001533 Informative Inherited
Molecular Function (MF) enzyme binding 0.04809 Informative Inherited
Molecular Function (MF) serine-type endopeptidase inhibitor activity 0 Highly Informative Direct
Molecular Function (MF) steroid binding 0 Highly Informative Direct
Molecular Function (MF) heparin binding 5.5e-05 Highly Informative Direct
Molecular Function (MF) unfolded protein binding 5.706e-06 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) vesicle 6.169e-15 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) extracellular space 1.61e-15 Informative Direct
Cellular Component (CC) secretory granule 2.45e-06 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 4.473e-14 Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.1548Least InformativeInherited
Disease Ontology (DO)urinary system disease0.212Moderately InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.411Moderately InformativeInherited
Disease Ontology (DO)artery disease0.6278Moderately InformativeInherited
Disease Ontology (DO)kidney failure0.02719InformativeInherited
Disease Ontology (DO)hypertension0.6078InformativeInherited
Disease Ontology (DO)pre-eclampsia0.2052Highly InformativeInherited

Document: DO annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)pericellular component development variant2.613e-09Moderately InformativeDirect
Worm Phenotype (WP)basement membrane remodeling variant7.141e-10InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)NF stage0.004268Least InformativeInherited
Xenopus DEvelopment stage (XDE)tadpole stage3.2e-06InformativeDirect
Xenopus DEvelopment stage (XDE)NF stage 531.241e-05Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processHost-virus interaction0.04221Moderately InformativeInherited
Biological processHemostasis0InformativeDirect
Biological processAcute phase0Highly InformativeDirect
Biological processBlood coagulation0Highly InformativeDirect
Biological processModulation of host cell apoptosis by virus1.263e-10Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.0001197Moderately InformativeDirect
Cellular componentHost cytoplasm4.239e-08InformativeDirect
Coding sequence diversityPolymorphism8.38e-07Moderately InformativeDirect
DomainSignal0Least InformativeDirect
Molecular functionHeparin-binding0InformativeDirect
Molecular functionLipid-binding6.425e-09InformativeDirect
Molecular functionSteroid-binding0Highly InformativeDirect
Post-translational modificationProtease inhibitor0InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationSulfation6.226e-07InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000215 SSF56574 Protein matches
Abstract

Serpins (SERine Proteinase INhibitors) [PubMed14705960, PubMed2690952, PubMed8417965] belong to MEROPS inhibitor family I4, clan ID. Serpins are proteins that are primarily known as irreversible serine protease inhibitors active against S1 , S8 and C14 peptidases. There are both extra- and intra-cellular serpins, which are found in all groups of organisms with the notable exception of fungi [PubMed11116082, PubMed12411597]. In contrast to "rigid" proteinase inhibitors, such as those of the Kunitz or Kazal families, the serpins are metastable proteins (active-state proteins) which interact with their substrate and irreversibly trap the acyl intermediate as a result of a major conformational change [PubMed11116079]; they are best described as suicide substrate inhibitors. The common structure of these proteins is a multi-domain fold containing a bundle of 8 or 9 alpha helices and a beta sandwich formed by 3 beta sheets. The reactive centre loop (RCL) is found in the C-terminal part of these proteins.

Serpins and their homologues are a group of high molecular weight (40 to 50 kDa) structurally related proteins involved in a number of fundamental biological processes such as blood coagulation, complement activation, fibrinolysis, angiogenesis, inflammation, tumour suppression and hormone transport. All known serpins have been classified into 16 clades and 10 orphan sequences; the vertebrate serpins can be conveniently classified into six sub-groups [PubMed11116082]. In human plasma they represent approximately 2% of the total protein, of which 70% is alpha-1-antitrypsin. On the basis of strong sequence similarities, a number of proteins with no known inhibitory activity also belong to this family, these include: angiotensinogen, corticosteroid-binding globulin and thyroxin-binding globulin [PubMed12824063].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 17 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Serpins domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 17 hidden Markov models representing the Serpins superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]