SUPERFAMILY 1.75 HMM library and genome assignments server


Serpins superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Multi-domain proteins (alpha and beta) [ 56572] (66)
Fold:   Serpins [ 56573]
Superfamily:   Serpins [ 56574]
Families:   Serpins [ 56575] (16)


Superfamily statistics
Genomes (442) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 4,791 6,258 63
Proteins 4,572 6,125 63


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of metabolic process8.925e-112.621e-07Least InformativeDirect
Biological Process (BP)response to stimulus9.996e-066.014e-05Least InformativeDirect
Biological Process (BP)developmental process0.025940.9546Least InformativeInherited
Biological Process (BP)multicellular organismal process6.813e-080.008679Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)localization11Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.82171Least InformativeInherited
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)single-organism cellular process0.49771Least InformativeInherited
Biological Process (BP)protein metabolic process0.99641Least InformativeInherited
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process11Least InformativeInherited
Biological Process (BP)reproduction6.291e-121.111e-06Moderately InformativeDirect
Biological Process (BP)response to endogenous stimulus5.121e-089.481e-09Moderately InformativeDirect
Biological Process (BP)response to organic substance2.215e-072.01e-07Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process0.00019160.0001497Moderately InformativeDirect
Biological Process (BP)regulation of catalytic activity6.1e-052.125e-09Moderately InformativeDirect
Biological Process (BP)regulation of protein metabolic process00Moderately InformativeDirect
Biological Process (BP)multi-organism process4.732e-086.609e-07Moderately InformativeDirect
Biological Process (BP)response to oxygen-containing compound5.767e-088.573e-09Moderately InformativeDirect
Biological Process (BP)regulation of gene expression11Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.088061Moderately InformativeInherited
Biological Process (BP)gene expression0.36890.9987Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.11650.1683Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.44120.8514Moderately InformativeInherited
Biological Process (BP)organelle organization11Moderately InformativeInherited
Biological Process (BP)cellular localization0.7210.961Moderately InformativeInherited
Biological Process (BP)immune system process0.003910.03076Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.047180.3637Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.00055960.003314Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.451Moderately InformativeInherited
Biological Process (BP)signal transduction10.9465Moderately InformativeInherited
Biological Process (BP)carbohydrate metabolic process0.57240.7885Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.9591Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process0.43951Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process0.91661Moderately InformativeInherited
Biological Process (BP)tissue development0.021350.2734Moderately InformativeInherited
Biological Process (BP)organ development0.45510.7421Moderately InformativeInherited
Biological Process (BP)cell differentiation0.11141Moderately InformativeInherited
Biological Process (BP)defense response0.00049290.0007289InformativeDirect
Biological Process (BP)response to hormone stimulus3.605e-091.111e-11InformativeDirect
Biological Process (BP)response to organonitrogen compound3.264e-091.159e-10InformativeDirect
Biological Process (BP)negative regulation of cell communication0.00027510.000319InformativeDirect
Biological Process (BP)secretion by cell0.00064540.0003013InformativeDirect
Biological Process (BP)response to cytokine stimulus8.447e-130InformativeDirect
Biological Process (BP)negative regulation of catalytic activity00InformativeDirect
Biological Process (BP)regulation of body fluid levels8.04e-054.86e-05InformativeDirect
Biological Process (BP)negative regulation of protein metabolic process6.402e-085.586e-15InformativeDirect
Biological Process (BP)regulation of peptidase activity00InformativeDirect
Biological Process (BP)organ morphogenesis0.01060.3242InformativeInherited
Biological Process (BP)negative regulation of signaling0.003740.01126InformativeInherited
Biological Process (BP)negative regulation of response to stimulus0.0017092.079e-06InformativeInherited
Biological Process (BP)regulation of response to external stimulus0.0045338.595e-08InformativeInherited
Biological Process (BP)immune response0.0050080.002614InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.61160.4361InformativeInherited
Biological Process (BP)negative regulation of developmental process0.54651InformativeInherited
Biological Process (BP)hemostasis3.151e-068.524e-07Highly InformativeDirect
Biological Process (BP)response to fungus0.00074021.783e-06Highly InformativeDirect
Biological Process (BP)negative regulation of endopeptidase activity6.12e-051.652e-12Highly InformativeDirect
Biological Process (BP)vesicle organization1.171e-050.0001006Highly InformativeDirect
Biological Process (BP)regulation of proteolysis9.698e-110Highly InformativeDirect
Biological Process (BP)extracellular matrix organization3.291e-109.276e-10Highly InformativeDirect
Biological Process (BP)negative regulation of hormone metabolic process2.065e-093.884e-13Highly InformativeDirect
Biological Process (BP)collagen metabolic process1.111e-091.215e-08Highly InformativeDirect
Biological Process (BP)response to peptide hormone stimulus2.548e-086.074e-11Highly InformativeDirect
Biological Process (BP)regulation of angiogenesis1.855e-053.804e-07Highly InformativeDirect
Biological Process (BP)coagulation1.418e-057.315e-07Highly InformativeDirect
Biological Process (BP)regulation of coagulation2.477e-091.655e-12Highly InformativeDirect
Biological Process (BP)regulation of wound healing1.046e-095.677e-08Highly InformativeDirect
Biological Process (BP)connective tissue development0.00013120.0004519Highly InformativeDirect
Biological Process (BP)regulation of protein processing4.708e-130Highly InformativeDirect
Biological Process (BP)regulation of hemostasis2.103e-081.844e-11Highly InformativeDirect
Biological Process (BP)negative regulation of multicellular organismal process0.11180.08797Highly InformativeInherited
Biological Process (BP)negative regulation of cell proliferation0.10740.1092Highly InformativeInherited
Biological Process (BP)regulation of reproductive process0.028210.08017Highly InformativeInherited
Biological Process (BP)skeletal system development0.00080660.01648Highly InformativeInherited
Biological Process (BP)humoral immune response0.0012494.452e-07Highly InformativeInherited
Biological Process (BP)protein glycosylation0.00015720.001976Highly InformativeInherited
Molecular Function (MF)binding1.885e-070.01814Least InformativeInherited
Molecular Function (MF)enzyme regulator activity00Moderately InformativeDirect
Molecular Function (MF)anion binding0.51760.4596Moderately InformativeInherited
Molecular Function (MF)enzyme inhibitor activity00InformativeDirect
Molecular Function (MF)lipid binding7.465e-073.095e-08InformativeDirect
Molecular Function (MF)peptidase regulator activity00InformativeDirect
Molecular Function (MF)carbohydrate derivative binding0.021190.003614InformativeInherited
Molecular Function (MF)sulfur compound binding0.017220.001275InformativeInherited
Molecular Function (MF)enzyme binding0.029290.06219InformativeInherited
Molecular Function (MF)serine-type endopeptidase inhibitor activity00Highly InformativeDirect
Molecular Function (MF)steroid binding6.944e-150Highly InformativeDirect
Molecular Function (MF)heparin binding0.00071095.183e-05Highly InformativeDirect
Molecular Function (MF)unfolded protein binding2.053e-063.137e-06Highly InformativeDirect
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)intracellular organelle part11Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)vesicle5.561e-104.877e-09Moderately InformativeDirect
Cellular Component (CC)extracellular region part00Moderately InformativeDirect
Cellular Component (CC)extracellular space1.399e-070InformativeDirect
Cellular Component (CC)secretory granule0.00054052.653e-06InformativeDirect
Cellular Component (CC)extracellular membrane-bounded organelle4.553e-062.895e-06InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of metabolic process 2.621e-07 Least Informative Direct
Biological Process (BP) response to stimulus 6.014e-05 Least Informative Direct
Biological Process (BP) developmental process 0.9546 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.008679 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) reproduction 1.111e-06 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 9.481e-09 Moderately Informative Direct
Biological Process (BP) response to organic substance 2.01e-07 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.0001497 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 2.125e-09 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0 Moderately Informative Direct
Biological Process (BP) multi-organism process 6.609e-07 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 8.573e-09 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) gene expression 0.9987 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.1683 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.8514 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.961 Moderately Informative Inherited
Biological Process (BP) immune system process 0.03076 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.3637 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.003314 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.9465 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.7885 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) system process 0.2543 Moderately Informative Inherited
Biological Process (BP) tissue development 0.2734 Moderately Informative Inherited
Biological Process (BP) organ development 0.7421 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) defense response 0.0007289 Informative Direct
Biological Process (BP) blood circulation 0.0002747 Informative Direct
Biological Process (BP) response to wounding 9.629e-05 Informative Direct
Biological Process (BP) response to hormone stimulus 1.111e-11 Informative Direct
Biological Process (BP) response to organonitrogen compound 1.159e-10 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.000319 Informative Direct
Biological Process (BP) regulation of response to external stimulus 8.595e-08 Informative Direct
Biological Process (BP) secretion by cell 0.0003013 Informative Direct
Biological Process (BP) response to cytokine stimulus 0 Informative Direct
Biological Process (BP) negative regulation of catalytic activity 0 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 2.079e-06 Informative Direct
Biological Process (BP) regulation of body fluid levels 4.86e-05 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 4.533e-06 Informative Direct
Biological Process (BP) negative regulation of protein metabolic process 5.586e-15 Informative Direct
Biological Process (BP) regulation of peptidase activity 0 Informative Direct
Biological Process (BP) organ morphogenesis 0.3242 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.01126 Informative Inherited
Biological Process (BP) regulation of defense response 0.5532 Informative Inherited
Biological Process (BP) immune response 0.002614 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.4361 Informative Inherited
Biological Process (BP) negative regulation of developmental process 1 Informative Inherited
Biological Process (BP) regulation of immune response 0.4588 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.01105 Informative Inherited
Biological Process (BP) regulation of humoral immune response 0.0001642 Highly Informative Direct
Biological Process (BP) vascular process in circulatory system 0.000455 Highly Informative Direct
Biological Process (BP) humoral immune response 4.452e-07 Highly Informative Direct
Biological Process (BP) hemostasis 8.524e-07 Highly Informative Direct
Biological Process (BP) regulation of blood pressure 4.295e-05 Highly Informative Direct
Biological Process (BP) response to fungus 1.783e-06 Highly Informative Direct
Biological Process (BP) negative regulation of endopeptidase activity 1.652e-12 Highly Informative Direct
Biological Process (BP) vesicle organization 0.0001006 Highly Informative Direct
Biological Process (BP) regulation of proteolysis 0 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 9.276e-10 Highly Informative Direct
Biological Process (BP) negative regulation of hormone metabolic process 3.884e-13 Highly Informative Direct
Biological Process (BP) collagen metabolic process 1.215e-08 Highly Informative Direct
Biological Process (BP) response to peptide hormone stimulus 6.074e-11 Highly Informative Direct
Biological Process (BP) regulation of angiogenesis 3.804e-07 Highly Informative Direct
Biological Process (BP) coagulation 7.315e-07 Highly Informative Direct
Biological Process (BP) regulation of coagulation 1.655e-12 Highly Informative Direct
Biological Process (BP) regulation of wound healing 5.677e-08 Highly Informative Direct
Biological Process (BP) connective tissue development 0.0004519 Highly Informative Direct
Biological Process (BP) regulation of protein processing 0 Highly Informative Direct
Biological Process (BP) regulation of hemostasis 1.844e-11 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.08797 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 0.1092 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.08017 Highly Informative Inherited
Biological Process (BP) skeletal system development 0.01648 Highly Informative Inherited
Biological Process (BP) regulation of innate immune response 0.09928 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.0237 Highly Informative Inherited
Biological Process (BP) protein glycosylation 0.001976 Highly Informative Inherited
Molecular Function (MF) binding 0.01814 Least Informative Inherited
Molecular Function (MF) enzyme regulator activity 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.4596 Moderately Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 0 Informative Direct
Molecular Function (MF) lipid binding 3.095e-08 Informative Direct
Molecular Function (MF) peptidase regulator activity 0 Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.003614 Informative Inherited
Molecular Function (MF) sulfur compound binding 0.001275 Informative Inherited
Molecular Function (MF) enzyme binding 0.06219 Informative Inherited
Molecular Function (MF) serine-type endopeptidase inhibitor activity 0 Highly Informative Direct
Molecular Function (MF) steroid binding 0 Highly Informative Direct
Molecular Function (MF) heparin binding 5.183e-05 Highly Informative Direct
Molecular Function (MF) unfolded protein binding 3.137e-06 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) vesicle 4.877e-09 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) extracellular space 0 Informative Direct
Cellular Component (CC) secretory granule 2.653e-06 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 2.895e-06 Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.1403Least InformativeInherited
Disease Ontology (DO)kidney disease0.08272Moderately InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.4082Moderately InformativeInherited
Disease Ontology (DO)artery disease0.631Moderately InformativeInherited
Disease Ontology (DO)kidney failure0.02767InformativeInherited
Disease Ontology (DO)hypertension0.609InformativeInherited
Disease Ontology (DO)pre-eclampsia0.2045Highly InformativeInherited

Document: DO annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)pericellular component development variant2.613e-09Moderately InformativeDirect
Worm Phenotype (WP)basement membrane remodeling variant7.141e-10InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)NF stage0.004318Least InformativeInherited
Xenopus DEvelopment stage (XDE)tadpole stage3.074e-06InformativeDirect
Xenopus DEvelopment stage (XDE)NF stage 531.249e-05Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processHost-virus interaction0.04234Moderately InformativeInherited
Biological processHemostasis0InformativeDirect
Biological processAcute phase0Highly InformativeDirect
Biological processBlood coagulation0Highly InformativeDirect
Biological processModulation of host cell apoptosis by virus1.126e-10Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.0001095Moderately InformativeDirect
Cellular componentHost cytoplasm3.471e-08InformativeDirect
Coding sequence diversityPolymorphism9.892e-07Moderately InformativeDirect
DomainSignal0Least InformativeDirect
Molecular functionHeparin-binding0InformativeDirect
Molecular functionLipid-binding3.571e-09InformativeDirect
Molecular functionSteroid-binding0Highly InformativeDirect
Post-translational modificationProtease inhibitor0InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationSulfation6.598e-07InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000215 SSF56574 Protein matches
Abstract

Serpins (SERine Proteinase INhibitors) [PubMed14705960, PubMed2690952, PubMed8417965] belong to MEROPS inhibitor family I4, clan ID. Serpins are proteins that are primarily known as irreversible serine protease inhibitors active against S1 , S8 and C14 peptidases. There are both extra- and intra-cellular serpins, which are found in all groups of organisms with the notable exception of fungi [PubMed11116082, PubMed12411597]. In contrast to "rigid" proteinase inhibitors, such as those of the Kunitz or Kazal families, the serpins are metastable proteins (active-state proteins) which interact with their substrate and irreversibly trap the acyl intermediate as a result of a major conformational change [PubMed11116079]; they are best described as suicide substrate inhibitors. The common structure of these proteins is a multi-domain fold containing a bundle of 8 or 9 alpha helices and a beta sandwich formed by 3 beta sheets. The reactive centre loop (RCL) is found in the C-terminal part of these proteins.

Serpins and their homologues are a group of high molecular weight (40 to 50 kDa) structurally related proteins involved in a number of fundamental biological processes such as blood coagulation, complement activation, fibrinolysis, angiogenesis, inflammation, tumour suppression and hormone transport. All known serpins have been classified into 16 clades and 10 orphan sequences; the vertebrate serpins can be conveniently classified into six sub-groups [PubMed11116082]. In human plasma they represent approximately 2% of the total protein, of which 70% is alpha-1-antitrypsin. On the basis of strong sequence similarities, a number of proteins with no known inhibitory activity also belong to this family, these include: angiotensinogen, corticosteroid-binding globulin and thyroxin-binding globulin [PubMed12824063].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 17 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Serpins domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 17 hidden Markov models representing the Serpins superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]