SUPERFAMILY 1.75 HMM library and genome assignments server

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Serpins superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Multi-domain proteins (alpha and beta) [ 56572] (66)
Fold:   Serpins [ 56573]
Superfamily:   Serpins [ 56574]
Families:   Serpins [ 56575] (16)


Superfamily statistics
Genomes (475) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 5,387 7,957 63
Proteins 5,087 7,757 63


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of metabolic process0.0000000000013070.00000002286Least InformativeDirect
Biological Process (BP)response to stimulus0.000022390.0001235Least InformativeDirect
Biological Process (BP)developmental process0.0065230.7444Least InformativeInherited
Biological Process (BP)multicellular organismal process0.000000006460.003935Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)localization11Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.86841Least InformativeInherited
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)single-organism cellular process0.28781Least InformativeInherited
Biological Process (BP)protein metabolic process11Least InformativeInherited
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process11Least InformativeInherited
Biological Process (BP)reproduction0.000000000001850.0000005448Moderately InformativeDirect
Biological Process (BP)response to endogenous stimulus0.000000056820.00000001663Moderately InformativeDirect
Biological Process (BP)response to organic substance0.00000037540.000000394Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process0.000022590.00004182Moderately InformativeDirect
Biological Process (BP)regulation of catalytic activity0.00014140.000000009068Moderately InformativeDirect
Biological Process (BP)regulation of protein metabolic process0.0000000000000079780Moderately InformativeDirect
Biological Process (BP)multi-organism process0.00000015090.000001838Moderately InformativeDirect
Biological Process (BP)response to oxygen-containing compound0.000000062280.00000000878Moderately InformativeDirect
Biological Process (BP)cellular response to chemical stimulus11Moderately InformativeInherited
Biological Process (BP)regulation of gene expression11Moderately InformativeInherited
Biological Process (BP)gene expression0.40391Moderately InformativeInherited
Biological Process (BP)regulation of biological quality11Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.18020.2396Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.6520.8929Moderately InformativeInherited
Biological Process (BP)organelle organization11Moderately InformativeInherited
Biological Process (BP)cellular localization0.75280.9888Moderately InformativeInherited
Biological Process (BP)immune system process0.00036540.006448Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.062840.4646Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.29931Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.00010420.001514Moderately InformativeInherited
Biological Process (BP)signal transduction10.9757Moderately InformativeInherited
Biological Process (BP)carbohydrate metabolic process0.58440.798Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.95871Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process0.47091Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process0.94561Moderately InformativeInherited
Biological Process (BP)tissue development0.06230.312Moderately InformativeInherited
Biological Process (BP)organ development0.29940.5079Moderately InformativeInherited
Biological Process (BP)cell differentiation0.012670.9699Moderately InformativeInherited
Biological Process (BP)defense response0.00055590.0007627InformativeDirect
Biological Process (BP)response to wounding0.00083420.00007859InformativeDirect
Biological Process (BP)response to hormone stimulus0.0000000043660.00000000001268InformativeDirect
Biological Process (BP)response to organonitrogen compound0.0000000017810.0000000001056InformativeDirect
Biological Process (BP)negative regulation of cell communication0.00077020.0009856InformativeDirect
Biological Process (BP)secretion by cell0.00087960.0003387InformativeDirect
Biological Process (BP)response to cytokine stimulus0.00000000000110InformativeDirect
Biological Process (BP)regulation of cell proliferation0.0001530.000001979InformativeDirect
Biological Process (BP)negative regulation of catalytic activity00InformativeDirect
Biological Process (BP)regulation of body fluid levels0.00018710.00005009InformativeDirect
Biological Process (BP)negative regulation of protein metabolic process0.00000020740.00000000000002793InformativeDirect
Biological Process (BP)regulation of peptidase activity00InformativeDirect
Biological Process (BP)response to organic cyclic compound0.83651InformativeInherited
Biological Process (BP)response to lipid0.76340.8781InformativeInherited
Biological Process (BP)cellular response to endogenous stimulus11InformativeInherited
Biological Process (BP)organ morphogenesis0.0290.3626InformativeInherited
Biological Process (BP)negative regulation of signaling0.0055180.01904InformativeInherited
Biological Process (BP)negative regulation of response to stimulus0.0031520.000005848InformativeInherited
Biological Process (BP)regulation of response to external stimulus0.0092280.0000002416InformativeInherited
Biological Process (BP)immune response0.0078620.003954InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.55940.4076InformativeInherited
Biological Process (BP)negative regulation of developmental process0.62561InformativeInherited
Biological Process (BP)humoral immune response0.00092330.000000347Highly InformativeDirect
Biological Process (BP)hemostasis0.0000030550.0000008495Highly InformativeDirect
Biological Process (BP)response to fungus0.00038420.000001165Highly InformativeDirect
Biological Process (BP)negative regulation of endopeptidase activity0.000018980.000000000001012Highly InformativeDirect
Biological Process (BP)vesicle organization0.000018940.0001339Highly InformativeDirect
Biological Process (BP)regulation of proteolysis0.000000000077350Highly InformativeDirect
Biological Process (BP)negative regulation of hormone metabolic process0.0000000033890.0000000000007707Highly InformativeDirect
Biological Process (BP)response to peptide hormone stimulus0.000000011770.00000000003663Highly InformativeDirect
Biological Process (BP)multicellular organismal metabolic process0.0000000016550.00000004315Highly InformativeDirect
Biological Process (BP)regulation of angiogenesis0.000014150.0000003118Highly InformativeDirect
Biological Process (BP)coagulation0.000024040.0000007317Highly InformativeDirect
Biological Process (BP)regulation of coagulation0.0000000012420.000000000001755Highly InformativeDirect
Biological Process (BP)regulation of wound healing0.0000000023770.00000007367Highly InformativeDirect
Biological Process (BP)connective tissue development0.00013160.0005174Highly InformativeDirect
Biological Process (BP)regulation of protein processing0.0000000000034110Highly InformativeDirect
Biological Process (BP)cellular response to steroid hormone stimulus0.00044150.0000465Highly InformativeDirect
Biological Process (BP)regulation of hemostasis0.000000011360.00000000002031Highly InformativeDirect
Biological Process (BP)negative regulation of multicellular organismal process0.11810.09379Highly InformativeInherited
Biological Process (BP)negative regulation of cell proliferation0.12410.1207Highly InformativeInherited
Biological Process (BP)regulation of reproductive process0.034020.08672Highly InformativeInherited
Biological Process (BP)skeletal system development0.0016590.0188Highly InformativeInherited
Biological Process (BP)protein glycosylation0.00015810.001795Highly InformativeInherited
Molecular Function (MF)binding0.000000065390.0121Least InformativeInherited
Molecular Function (MF)enzyme regulator activity00Moderately InformativeDirect
Molecular Function (MF)anion binding0.55580.5022Moderately InformativeInherited
Molecular Function (MF)enzyme inhibitor activity00InformativeDirect
Molecular Function (MF)lipid binding0.00000083440.00000004352InformativeDirect
Molecular Function (MF)peptidase regulator activity00InformativeDirect
Molecular Function (MF)carbohydrate derivative binding0.023580.004018InformativeInherited
Molecular Function (MF)sulfur compound binding0.018690.001569InformativeInherited
Molecular Function (MF)enzyme binding0.017080.05144InformativeInherited
Molecular Function (MF)serine-type endopeptidase inhibitor activity00Highly InformativeDirect
Molecular Function (MF)steroid binding0.0000000000000051660Highly InformativeDirect
Molecular Function (MF)heparin binding0.00074790.00005715Highly InformativeDirect
Molecular Function (MF)unfolded protein binding0.0000036880.000004667Highly InformativeDirect
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)intracellular organelle part11Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)vesicle0.00000000000064520.00000000000001045Moderately InformativeDirect
Cellular Component (CC)extracellular region part00Moderately InformativeDirect
Cellular Component (CC)extracellular space0.000000038430.000000000000003095InformativeDirect
Cellular Component (CC)secretory granule0.0004470.000002451InformativeDirect
Cellular Component (CC)extracellular membrane-bounded organelle0.0000000015310.00000000000005343InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of metabolic process 0.00000002286 Least Informative Direct
Biological Process (BP) response to stimulus 0.0001235 Least Informative Direct
Biological Process (BP) developmental process 0.7444 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.003935 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) reproduction 0.0000005448 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0.00000001663 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.000000394 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.00004182 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0.000000009068 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.000001838 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.00000000878 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.2396 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.8929 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.9888 Moderately Informative Inherited
Biological Process (BP) immune system process 0.006448 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.4646 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.001514 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.9757 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.798 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) system process 0.2921 Moderately Informative Inherited
Biological Process (BP) tissue development 0.312 Moderately Informative Inherited
Biological Process (BP) organ development 0.5079 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.9699 Moderately Informative Inherited
Biological Process (BP) defense response 0.0007627 Informative Direct
Biological Process (BP) blood circulation 0.0003424 Informative Direct
Biological Process (BP) response to wounding 0.00007859 Informative Direct
Biological Process (BP) response to hormone stimulus 0.00000000001268 Informative Direct
Biological Process (BP) response to organonitrogen compound 0.0000000001056 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.0009856 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0.0000002416 Informative Direct
Biological Process (BP) secretion by cell 0.0003387 Informative Direct
Biological Process (BP) response to cytokine stimulus 0 Informative Direct
Biological Process (BP) regulation of cell proliferation 0.000001979 Informative Direct
Biological Process (BP) negative regulation of catalytic activity 0 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.000005848 Informative Direct
Biological Process (BP) regulation of body fluid levels 0.00005009 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.000005712 Informative Direct
Biological Process (BP) negative regulation of protein metabolic process 0.00000000000002793 Informative Direct
Biological Process (BP) regulation of peptidase activity 0 Informative Direct
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) response to lipid 0.8781 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 1 Informative Inherited
Biological Process (BP) organ morphogenesis 0.3626 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.01904 Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.02878 Informative Inherited
Biological Process (BP) regulation of defense response 0.5074 Informative Inherited
Biological Process (BP) immune response 0.003954 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.4076 Informative Inherited
Biological Process (BP) negative regulation of developmental process 1 Informative Inherited
Biological Process (BP) regulation of ion transport 0.01088 Informative Inherited
Biological Process (BP) regulation of immune response 0.4944 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.01629 Informative Inherited
Biological Process (BP) regulation of humoral immune response 0.0001618 Highly Informative Direct
Biological Process (BP) vascular process in circulatory system 0.0003684 Highly Informative Direct
Biological Process (BP) humoral immune response 0.000000347 Highly Informative Direct
Biological Process (BP) hemostasis 0.0000008495 Highly Informative Direct
Biological Process (BP) regulation of blood pressure 0.00004613 Highly Informative Direct
Biological Process (BP) response to fungus 0.000001165 Highly Informative Direct
Biological Process (BP) negative regulation of endopeptidase activity 0.000000000001012 Highly Informative Direct
Biological Process (BP) vesicle organization 0.0001339 Highly Informative Direct
Biological Process (BP) regulation of proteolysis 0 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0.0000000009218 Highly Informative Direct
Biological Process (BP) negative regulation of hormone metabolic process 0.0000000000007707 Highly Informative Direct
Biological Process (BP) response to peptide hormone stimulus 0.00000000003663 Highly Informative Direct
Biological Process (BP) multicellular organismal metabolic process 0.00000004315 Highly Informative Direct
Biological Process (BP) regulation of angiogenesis 0.0000003118 Highly Informative Direct
Biological Process (BP) negative regulation of immune response 0.0005603 Highly Informative Direct
Biological Process (BP) coagulation 0.0000007317 Highly Informative Direct
Biological Process (BP) regulation of coagulation 0.000000000001755 Highly Informative Direct
Biological Process (BP) regulation of wound healing 0.00000007367 Highly Informative Direct
Biological Process (BP) connective tissue development 0.0005174 Highly Informative Direct
Biological Process (BP) regulation of protein processing 0 Highly Informative Direct
Biological Process (BP) cellular response to steroid hormone stimulus 0.0000465 Highly Informative Direct
Biological Process (BP) regulation of hemostasis 0.00000000002031 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.09379 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 0.1207 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.08672 Highly Informative Inherited
Biological Process (BP) skeletal system development 0.0188 Highly Informative Inherited
Biological Process (BP) regulation of innate immune response 0.09129 Highly Informative Inherited
Biological Process (BP) protein glycosylation 0.001795 Highly Informative Inherited
Molecular Function (MF) binding 0.0121 Least Informative Inherited
Molecular Function (MF) enzyme regulator activity 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.5022 Moderately Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 0 Informative Direct
Molecular Function (MF) lipid binding 0.00000004352 Informative Direct
Molecular Function (MF) peptidase regulator activity 0 Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.004018 Informative Inherited
Molecular Function (MF) sulfur compound binding 0.001569 Informative Inherited
Molecular Function (MF) enzyme binding 0.05144 Informative Inherited
Molecular Function (MF) serine-type endopeptidase inhibitor activity 0 Highly Informative Direct
Molecular Function (MF) steroid binding 0 Highly Informative Direct
Molecular Function (MF) heparin binding 0.00005715 Highly Informative Direct
Molecular Function (MF) unfolded protein binding 0.000004667 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) vesicle 0.00000000000001045 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) extracellular space 0.000000000000003095 Informative Direct
Cellular Component (CC) secretory granule 0.000002451 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 0.00000000000005343 Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.143Least InformativeInherited
Disease Ontology (DO)urinary system disease0.2141Moderately InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.4072Moderately InformativeInherited
Disease Ontology (DO)kidney failure0.02887InformativeInherited

Document: DO annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)pericellular component development variant0.000000002613Moderately InformativeDirect
Worm Phenotype (WP)basement membrane remodeling variant0.0000000007141InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)NF stage0.004261Least InformativeInherited
Xenopus DEvelopment stage (XDE)tadpole stage0.000003197InformativeDirect
Xenopus DEvelopment stage (XDE)NF stage 530.00001241Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processHost-virus interaction0.04223Moderately InformativeInherited
Biological processHemostasis0InformativeDirect
Biological processAcute phase0Highly InformativeDirect
Biological processBlood coagulation0Highly InformativeDirect
Biological processModulation of host cell apoptosis by virus0.0000000001255Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.0001245Moderately InformativeDirect
Cellular componentHost cytoplasm0.00000004197InformativeDirect
Coding sequence diversityPolymorphism0.0000005989Moderately InformativeDirect
DomainSignal0Least InformativeDirect
Molecular functionHeparin-binding0InformativeDirect
Molecular functionLipid-binding0.000000006439InformativeDirect
Molecular functionSteroid-binding0Highly InformativeDirect
Post-translational modificationProtease inhibitor0InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationSulfation0.0000006345InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000215 SSF56574 Protein matches
Abstract

Serpins (SERine Proteinase INhibitors) [PubMed14705960, PubMed2690952, PubMed8417965] belong to MEROPS inhibitor family I4, clan ID. Serpins are proteins that are primarily known as irreversible serine protease inhibitors active against S1 , S8 and C14 peptidases. There are both extra- and intra-cellular serpins, which are found in all groups of organisms with the notable exception of fungi [PubMed11116082, PubMed12411597]. In contrast to "rigid" proteinase inhibitors, such as those of the Kunitz or Kazal families, the serpins are metastable proteins (active-state proteins) which interact with their substrate and irreversibly trap the acyl intermediate as a result of a major conformational change [PubMed11116079]; they are best described as suicide substrate inhibitors. The common structure of these proteins is a multi-domain fold containing a bundle of 8 or 9 alpha helices and a beta sandwich formed by 3 beta sheets. The reactive centre loop (RCL) is found in the C-terminal part of these proteins.

Serpins and their homologues are a group of high molecular weight (40 to 50 kDa) structurally related proteins involved in a number of fundamental biological processes such as blood coagulation, complement activation, fibrinolysis, angiogenesis, inflammation, tumour suppression and hormone transport. All known serpins have been classified into 16 clades and 10 orphan sequences; the vertebrate serpins can be conveniently classified into six sub-groups [PubMed11116082]. In human plasma they represent approximately 2% of the total protein, of which 70% is alpha-1-antitrypsin. On the basis of strong sequence similarities, a number of proteins with no known inhibitory activity also belong to this family, these include: angiotensinogen, corticosteroid-binding globulin and thyroxin-binding globulin [PubMed12824063].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 17 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Serpins domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 17 hidden Markov models representing the Serpins superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]