SUPERFAMILY 1.75 HMM library and genome assignments server

Serpins superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Multi-domain proteins (alpha and beta) [ 56572] (66)
Fold:   Serpins [ 56573]
Superfamily:   Serpins [ 56574]
Families:   Serpins [ 56575] (16)


Superfamily statistics
Genomes (476) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 5,389 7,957 63
Proteins 5,088 7,757 63


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of metabolic process0.000000000012120.0000001167Least InformativeDirect
Biological Process (BP)response to stimulus0.0000012080.00001395Least InformativeDirect
Biological Process (BP)protein metabolic process11Least InformativeInherited
Biological Process (BP)localization11Least InformativeInherited
Biological Process (BP)multicellular organismal process0.0000000026890.001543Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.88391Least InformativeInherited
Biological Process (BP)regulation of cellular process0.16860.9656Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process11Least InformativeInherited
Biological Process (BP)developmental process0.0068960.7514Least InformativeInherited
Biological Process (BP)defense response0.00048590.0004234Moderately InformativeDirect
Biological Process (BP)response to endogenous stimulus0.00000000014430.00000000006974Moderately InformativeDirect
Biological Process (BP)negative regulation of metabolic process00.000000000000009016Moderately InformativeDirect
Biological Process (BP)response to organic substance0.00000000074570.000000029Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process00Moderately InformativeDirect
Biological Process (BP)regulation of catalytic activity0.000055420.000000004133Moderately InformativeDirect
Biological Process (BP)regulation of protein metabolic process00Moderately InformativeDirect
Biological Process (BP)multi-organism process0.00000098350.0000751Moderately InformativeDirect
Biological Process (BP)response to oxygen-containing compound0.000037640.000001854Moderately InformativeDirect
Biological Process (BP)cellular response to chemical stimulus0.95811Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.65110.8955Moderately InformativeInherited
Biological Process (BP)gene expression0.46311Moderately InformativeInherited
Biological Process (BP)organ development0.27570.4877Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.062970.464Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.097650.1346Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.32521Moderately InformativeInherited
Biological Process (BP)cellular localization0.77231Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization0.59160.9429Moderately InformativeInherited
Biological Process (BP)immune system process0.00035870.006533Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.42960.9581Moderately InformativeInherited
Biological Process (BP)response to external stimulus0.0033040.04527Moderately InformativeInherited
Biological Process (BP)signal transduction11Moderately InformativeInherited
Biological Process (BP)regulation of biological quality11Moderately InformativeInherited
Biological Process (BP)carbohydrate metabolic process0.59730.8058Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.96151Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process0.4731Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process0.97141Moderately InformativeInherited
Biological Process (BP)tissue development0.020240.2226Moderately InformativeInherited
Biological Process (BP)cell differentiation0.014280.9855Moderately InformativeInherited
Biological Process (BP)response to organonitrogen compound0.00000026750.00000001311InformativeDirect
Biological Process (BP)negative regulation of protein processing00InformativeDirect
Biological Process (BP)negative regulation of cellular protein metabolic process00InformativeDirect
Biological Process (BP)secretion by cell0.00065640.0003388InformativeDirect
Biological Process (BP)response to cytokine0.00000000027610.0000000000001178InformativeDirect
Biological Process (BP)negative regulation of catalytic activity00InformativeDirect
Biological Process (BP)regulation of body fluid levels0.00019860.00004915InformativeDirect
Biological Process (BP)protein maturation0.00010630.0001149InformativeDirect
Biological Process (BP)regulation of peptidase activity0.00000079320.000000000002742InformativeDirect
Biological Process (BP)defense response to other organism0.000014640.000001228InformativeDirect
Biological Process (BP)regulation of response to wounding0.00046040.000000009291InformativeDirect
Biological Process (BP)regulation of anatomical structure morphogenesis0.54090.3815InformativeInherited
Biological Process (BP)negative regulation of multicellular organismal process0.10270.454InformativeInherited
Biological Process (BP)response to organic cyclic compound0.97871InformativeInherited
Biological Process (BP)cellular response to hormone stimulus11InformativeInherited
Biological Process (BP)response to lipid0.94111InformativeInherited
Biological Process (BP)negative regulation of response to stimulus0.051930.0003633InformativeInherited
Biological Process (BP)regulation of response to external stimulus0.0017460.0000003917InformativeInherited
Biological Process (BP)regulation of cell proliferation0.04010.002481InformativeInherited
Biological Process (BP)organ morphogenesis0.050390.3604InformativeInherited
Biological Process (BP)negative regulation of cell communication0.25430.3322InformativeInherited
Biological Process (BP)negative regulation of signaling0.14960.3108InformativeInherited
Biological Process (BP)negative regulation of nitrogen compound metabolic process0.90491InformativeInherited
Biological Process (BP)negative regulation of developmental process0.43691InformativeInherited
Biological Process (BP)immune response0.013420.006282InformativeInherited
Biological Process (BP)humoral immune response0.0009160.0000003393Highly InformativeDirect
Biological Process (BP)hemostasis0.0000030230.0000008274Highly InformativeDirect
Biological Process (BP)response to fungus0.00037170.000001099Highly InformativeDirect
Biological Process (BP)negative regulation of endopeptidase activity0.000018880.000000000001067Highly InformativeDirect
Biological Process (BP)vesicle organization0.000020040.0001636Highly InformativeDirect
Biological Process (BP)negative regulation of hormone metabolic process0.0000001180.00000000005148Highly InformativeDirect
Biological Process (BP)collagen metabolic process0.00000000099680.00000001521Highly InformativeDirect
Biological Process (BP)response to peptide hormone0.0000000099410.00000000003509Highly InformativeDirect
Biological Process (BP)coagulation0.000028220.0000007116Highly InformativeDirect
Biological Process (BP)negative regulation of coagulation0.000023270.0000002828Highly InformativeDirect
Biological Process (BP)connective tissue development0.00029280.0007886Highly InformativeDirect
Biological Process (BP)cellular response to steroid hormone stimulus0.00048830.00004951Highly InformativeDirect
Biological Process (BP)negative regulation of hemostasis0.0000081860.00000007807Highly InformativeDirect
Biological Process (BP)cellular response to growth factor stimulus0.00015740.003015Highly InformativeInherited
Biological Process (BP)regulation of wound healing0.00000044540.002989Highly InformativeInherited
Biological Process (BP)negative regulation of response to external stimulus0.011130.01008Highly InformativeInherited
Biological Process (BP)negative regulation of response to wounding0.0011630.00009564Highly InformativeInherited
Biological Process (BP)negative regulation of cell proliferation0.66230.6892Highly InformativeInherited
Biological Process (BP)regulation of reproductive process0.017620.05017Highly InformativeInherited
Biological Process (BP)skeletal system development0.0017160.01928Highly InformativeInherited
Biological Process (BP)extracellular matrix organization10.0000000008822Highly InformativeInherited
Biological Process (BP)protein glycosylation0.00015640.0018Highly InformativeInherited
Molecular Function (MF)binding0.000000081810.01475Least InformativeInherited
Molecular Function (MF)enzyme regulator activity00Moderately InformativeDirect
Molecular Function (MF)anion binding0.55730.5021Moderately InformativeInherited
Molecular Function (MF)carbohydrate derivative binding0.90830.4964Moderately InformativeInherited
Molecular Function (MF)enzyme inhibitor activity00InformativeDirect
Molecular Function (MF)lipid binding0.00000083520.00000004296InformativeDirect
Molecular Function (MF)peptidase regulator activity00InformativeDirect
Molecular Function (MF)sulfur compound binding0.030490.002127InformativeInherited
Molecular Function (MF)enzyme binding0.018010.05291InformativeInherited
Molecular Function (MF)serine-type endopeptidase inhibitor activity00Highly InformativeDirect
Molecular Function (MF)steroid binding0.0000000000000052090Highly InformativeDirect
Molecular Function (MF)heparin binding0.0007520.00005738Highly InformativeDirect
Molecular Function (MF)unfolded protein binding0.0000036380.000004608Highly InformativeDirect
Cellular Component (CC)intracellular organelle part11Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)vesicle0.00000000000064780.00000000000001464Moderately InformativeDirect
Cellular Component (CC)extracellular region part00Moderately InformativeDirect
Cellular Component (CC)extracellular space0.000000042480.00000000000000158InformativeDirect
Cellular Component (CC)secretory granule0.00028060.0000004517InformativeDirect
Cellular Component (CC)extracellular membrane-bounded organelle0.0000000015320.00000000000008249InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of metabolic process 0.0000001167 Least Informative Direct
Biological Process (BP) response to stimulus 0.00001395 Least Informative Direct
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) positive regulation of biological process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.001543 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.9656 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) developmental process 0.7514 Least Informative Inherited
Biological Process (BP) defense response 0.0004234 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0.00000000006974 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0.000000000000009016 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.000000029 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0.000000004133 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.0000751 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.000001854 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.8955 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) organ development 0.4877 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.464 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.1346 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.9429 Moderately Informative Inherited
Biological Process (BP) immune system process 0.006533 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.9581 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.04527 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.8058 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.2226 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.9855 Moderately Informative Inherited
Biological Process (BP) blood circulation 0.0003469 Informative Direct
Biological Process (BP) response to organonitrogen compound 0.00000001311 Informative Direct
Biological Process (BP) negative regulation of protein processing 0 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0.0000003917 Informative Direct
Biological Process (BP) negative regulation of cellular protein metabolic process 0 Informative Direct
Biological Process (BP) secretion by cell 0.0003388 Informative Direct
Biological Process (BP) response to cytokine 0.0000000000001178 Informative Direct
Biological Process (BP) negative regulation of catalytic activity 0 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.0003633 Informative Direct
Biological Process (BP) regulation of body fluid levels 0.00004915 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.00005326 Informative Direct
Biological Process (BP) protein maturation 0.0001149 Informative Direct
Biological Process (BP) regulation of peptidase activity 0.000000000002742 Informative Direct
Biological Process (BP) defense response to other organism 0.000001228 Informative Direct
Biological Process (BP) regulation of response to wounding 0.000000009291 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.3815 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.454 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) cellular response to hormone stimulus 1 Informative Inherited
Biological Process (BP) response to lipid 1 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.002481 Informative Inherited
Biological Process (BP) organ morphogenesis 0.3604 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.0163 Informative Inherited
Biological Process (BP) regulation of immune response 0.4909 Informative Inherited
Biological Process (BP) regulation of defense response 0.4597 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.3322 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.3108 Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.372 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of developmental process 1 Informative Inherited
Biological Process (BP) regulation of ion transport 0.01274 Informative Inherited
Biological Process (BP) immune response 0.006282 Informative Inherited
Biological Process (BP) regulation of humoral immune response 0.0001584 Highly Informative Direct
Biological Process (BP) vascular process in circulatory system 0.0003812 Highly Informative Direct
Biological Process (BP) humoral immune response 0.0000003393 Highly Informative Direct
Biological Process (BP) hemostasis 0.0000008274 Highly Informative Direct
Biological Process (BP) regulation of blood pressure 0.00004641 Highly Informative Direct
Biological Process (BP) response to fungus 0.000001099 Highly Informative Direct
Biological Process (BP) negative regulation of endopeptidase activity 0.000000000001067 Highly Informative Direct
Biological Process (BP) vesicle organization 0.0001636 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0.0000000008822 Highly Informative Direct
Biological Process (BP) negative regulation of hormone metabolic process 0.00000000005148 Highly Informative Direct
Biological Process (BP) collagen metabolic process 0.00000001521 Highly Informative Direct
Biological Process (BP) response to peptide hormone 0.00000000003509 Highly Informative Direct
Biological Process (BP) coagulation 0.0000007116 Highly Informative Direct
Biological Process (BP) negative regulation of coagulation 0.0000002828 Highly Informative Direct
Biological Process (BP) connective tissue development 0.0007886 Highly Informative Direct
Biological Process (BP) cellular response to steroid hormone stimulus 0.00004951 Highly Informative Direct
Biological Process (BP) negative regulation of hemostasis 0.00000007807 Highly Informative Direct
Biological Process (BP) negative regulation of response to wounding 0.00009564 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 0.003015 Highly Informative Inherited
Biological Process (BP) regulation of wound healing 0.002989 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.01008 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 0.6892 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.05017 Highly Informative Inherited
Biological Process (BP) skeletal system development 0.01928 Highly Informative Inherited
Biological Process (BP) negative regulation of defense response 0.01033 Highly Informative Inherited
Biological Process (BP) regulation of innate immune response 0.1396 Highly Informative Inherited
Biological Process (BP) negative regulation of immune response 0.004728 Highly Informative Inherited
Biological Process (BP) protein glycosylation 0.0018 Highly Informative Inherited
Molecular Function (MF) binding 0.01475 Least Informative Inherited
Molecular Function (MF) enzyme regulator activity 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.5021 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.4964 Moderately Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 0 Informative Direct
Molecular Function (MF) lipid binding 0.00000004296 Informative Direct
Molecular Function (MF) peptidase regulator activity 0 Informative Direct
Molecular Function (MF) sulfur compound binding 0.002127 Informative Inherited
Molecular Function (MF) enzyme binding 0.05291 Informative Inherited
Molecular Function (MF) serine-type endopeptidase inhibitor activity 0 Highly Informative Direct
Molecular Function (MF) steroid binding 0 Highly Informative Direct
Molecular Function (MF) heparin binding 0.00005738 Highly Informative Direct
Molecular Function (MF) unfolded protein binding 0.000004608 Highly Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) vesicle 0.00000000000001464 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) extracellular space 0.00000000000000158 Informative Direct
Cellular Component (CC) secretory granule 0.0000004517 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 0.00000000000008249 Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.143Least InformativeInherited
Disease Ontology (DO)urinary system disease0.2141Moderately InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.4072Moderately InformativeInherited
Disease Ontology (DO)kidney failure0.02887InformativeInherited

Document: DO annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)pericellular component development variant0.000000002613Moderately InformativeDirect
Worm Phenotype (WP)basement membrane remodeling variant0.0000000007141InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)NF stage0.004261Least InformativeInherited
Xenopus DEvelopment stage (XDE)tadpole stage0.000003197InformativeDirect
Xenopus DEvelopment stage (XDE)NF stage 530.00001241Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)blood and blood forming organs0Least InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processHost-virus interaction0.04223Moderately InformativeInherited
Biological processHemostasis0InformativeDirect
Biological processAcute phase0Highly InformativeDirect
Biological processBlood coagulation0Highly InformativeDirect
Biological processModulation of host cell apoptosis by virus0.0000000001255Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.0001245Moderately InformativeDirect
Cellular componentHost cytoplasm0.00000004197InformativeDirect
Coding sequence diversityPolymorphism0.0000005989Moderately InformativeDirect
DomainSignal0Least InformativeDirect
Molecular functionHeparin-binding0InformativeDirect
Molecular functionLipid-binding0.000000006439InformativeDirect
Molecular functionSteroid-binding0Highly InformativeDirect
Post-translational modificationProtease inhibitor0InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationSulfation0.0000006345InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000215 SSF56574 Protein matches
Abstract

Serpins (SERine Proteinase INhibitors) [PubMed14705960, PubMed2690952, PubMed8417965] belong to MEROPS inhibitor family I4, clan ID. Serpins are proteins that are primarily known as irreversible serine protease inhibitors active against S1 , S8 and C14 peptidases. There are both extra- and intra-cellular serpins, which are found in all groups of organisms with the notable exception of fungi [PubMed11116082, PubMed12411597]. In contrast to "rigid" proteinase inhibitors, such as those of the Kunitz or Kazal families, the serpins are metastable proteins (active-state proteins) which interact with their substrate and irreversibly trap the acyl intermediate as a result of a major conformational change [PubMed11116079]; they are best described as suicide substrate inhibitors. The common structure of these proteins is a multi-domain fold containing a bundle of 8 or 9 alpha helices and a beta sandwich formed by 3 beta sheets. The reactive centre loop (RCL) is found in the C-terminal part of these proteins.

Serpins and their homologues are a group of high molecular weight (40 to 50 kDa) structurally related proteins involved in a number of fundamental biological processes such as blood coagulation, complement activation, fibrinolysis, angiogenesis, inflammation, tumour suppression and hormone transport. All known serpins have been classified into 16 clades and 10 orphan sequences; the vertebrate serpins can be conveniently classified into six sub-groups [PubMed11116082]. In human plasma they represent approximately 2% of the total protein, of which 70% is alpha-1-antitrypsin. On the basis of strong sequence similarities, a number of proteins with no known inhibitory activity also belong to this family, these include: angiotensinogen, corticosteroid-binding globulin and thyroxin-binding globulin [PubMed12824063].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 17 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Serpins domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 17 hidden Markov models representing the Serpins superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · Internal database links ]