SUPERFAMILY 1.75 HMM library and genome assignments server

Aromatic aminoacid monoxygenases, catalytic and oligomerization domains superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Aromatic aminoacid monoxygenases, catalytic and oligomerization domains [ 56533]
Superfamily:   Aromatic aminoacid monoxygenases, catalytic and oligomerization domains [ 56534]
Families:   Aromatic aminoacid monoxygenases, catalytic and oligomerization domains [ 56535] (3)


Superfamily statistics
Genomes (619) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,123 2,699 10
Proteins 1,099 2,688 10


Functional annotation
General category coiled coil
Detailed category This is a complex coiled arrangement. The details of which will appear on this page shortly (some coiled coil details are being checked before they are included on the site). If you want to see examples of the states please click here here. If you require further details urgently please contact Owen Rackham

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular aromatic compound metabolic process0.00059950Least InformativeDirect
Biological Process (BP)organic cyclic compound metabolic process0.00088690Least InformativeDirect
Biological Process (BP)single-organism cellular process0.02731Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.0058130.00005183Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.0015870Least InformativeInherited
Biological Process (BP)cellular amino acid metabolic process0.000010080Moderately InformativeDirect
Molecular Function (MF)oxidoreductase activity0.00000031770Moderately InformativeDirect
Molecular Function (MF)monooxygenase activity0.0000000000003740Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge0.0000000000029360Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) biosynthetic process 0.00000000329 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.000009281 Least Informative Direct
Biological Process (BP) developmental process 0.00007041 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.00005183 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0 Least Informative Direct
Biological Process (BP) positive regulation of biological process 0.6863 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.01038 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.1954 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0.000000000001326 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.000388 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0.00000000001614 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 0.0000000000002936 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) single-organism catabolic process 0.2295 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.5033 Moderately Informative Inherited
Biological Process (BP) organ development 0.007776 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.05337 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.05608 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.05243 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.04463 Moderately Informative Inherited
Biological Process (BP) reproductive process 0.005762 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.3747 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.2584 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.008691 Moderately Informative Inherited
Biological Process (BP) cellular biogenic amine metabolic process 0.00000000000001414 Informative Direct
Biological Process (BP) synaptic transmission 0.0000001754 Informative Direct
Biological Process (BP) single-organism behavior 0.0000007203 Informative Direct
Biological Process (BP) neurological system process 0.00000006002 Informative Direct
Biological Process (BP) positive regulation of developmental process 0.0007666 Informative Direct
Biological Process (BP) organic hydroxy compound biosynthetic process 0 Informative Direct
Biological Process (BP) gland development 0.001811 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 0.1733 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.6037 Informative Inherited
Biological Process (BP) regulation of system process 0.002828 Informative Inherited
Biological Process (BP) sexual reproduction 0.2013 Informative Inherited
Biological Process (BP) cardiovascular system development 0.003985 Informative Inherited
Biological Process (BP) aging 0.0002532 Highly Informative Direct
Biological Process (BP) aromatic amino acid family biosynthetic process 0.000188 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 0 Highly Informative Direct
Biological Process (BP) indole-containing compound biosynthetic process 0.000000001005 Highly Informative Direct
Biological Process (BP) multi-organism behavior 0.00000005558 Highly Informative Direct
Biological Process (BP) mammary gland alveolus development 0.0000000002123 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) monooxygenase activity 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0 Highly Informative Direct
Cellular Component (CC) cell projection 0.000001505 Moderately Informative Direct
Cellular Component (CC) neuron projection 0.00000000473 Informative Direct
Cellular Component (CC) cell body 0.0000001361 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body phenotype0Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.03481Least InformativeInherited
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal hormone level0Moderately InformativeDirect
Mammalian Phenotype (MP)integument phenotype0Moderately InformativeDirect
Mammalian Phenotype (MP)respiratory system phenotype0.006915Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.01129Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)decreased body size0InformativeDirect
Mammalian Phenotype (MP)abnormal heartbeat0.0000392InformativeDirect
Mammalian Phenotype (MP)abnormal respiration0.0007277InformativeDirect
Mammalian Phenotype (MP)abnormal touch/ nociception0.005973InformativeInherited
Mammalian Phenotype (MP)abnormal serotonin level0Highly InformativeDirect
Mammalian Phenotype (MP)abnormal thermal nociception0.000007515Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0Least InformativeDirect
Worm Phenotype (WP)chemical response variant0Moderately InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect
Fly Phenotype (FP)behavior defective0InformativeDirect
Fly Phenotype (FP)feeding behavior defective0Highly InformativeDirect

Document: FP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen0InformativeDirect

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)alimentary tract and metabolism0Least InformativeDirect
Drugbank ATC_code (DB)other alimentary tract and metabolism products1InformativeInherited
Drugbank ATC_code (DB)sapropterin0Highly InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processPhenylalanine catabolism0Highly InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionIron0Moderately InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationMonooxygenase0Highly InformativeDirect
Post-translational modificationPhosphoprotein0.0000000000002499Least InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)aromatic compound metabolism0.00000001792Least InformativeDirect
UniPathway (UP)amino-acid metabolism0.000001037Least InformativeDirect
UniPathway (UP)amino-acid degradation0Moderately InformativeDirect
UniPathway (UP)aromatic compound biosynthesis0Moderately InformativeDirect
UniPathway (UP)amine and polyamine metabolism0.00000000002878Moderately InformativeDirect
UniPathway (UP)amine and polyamine biosynthesis0.000000000000001345InformativeDirect
UniPathway (UP)tryptophan metabolism0.000003136InformativeDirect
UniPathway (UP)catecholamine biosynthesis0Highly InformativeDirect
UniPathway (UP)L-phenylalanine degradation0.00000000002238Highly InformativeDirect
UniPathway (UP)L-tryptophan degradation0.0000000001891Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR001273 SSF56534 Protein matches
Abstract

Phenylalanine, tyrosine and tryptophan hydroxylases constitute a family of tetrahydrobiopterin-dependent aromatic amino acid hydroxylases, all of which are rate-limiting catalysts for important metabolic pathways [PubMed3475690]. The proteins are structurally and functionally related, each containing iron, and catalysing ring hydroxylation of aromatic amino acids, using tetra-hydrobiopterin (BH4) as a substrate. All are regulated by phosphorylation at serines in their N-termini. It has been suggested that the proteins each contain a conserved C-terminal catalytic (C) domain and an unrelated N-terminal regulatory (R) domain. It is possible that the R domains arose from genes that were recruited from different sources to combine with the common gene for the catalytic core. Thus, by combining with the same C domain, the proteins acquired the unique regulatory properties of the separate R domains.

A variety of enzymes belong to this family that includes, phenylalanine-4-hydroxylase from Chromobacterium violaceum where it is copper-dependent; it is iron-dependent in Pseudomonas aeruginosa, phenylalanine-4-hydroxylase catalyzes the conversion of phenylalanine to tyrosine. In humans, deficiencies are the cause of phenylketonuria, the most common inborn error of amino acid metabolism [PubMed9406548], tryptophan 5-hydroxylase catalyzes the rate-limiting step in serotonin biosynthesis: the conversion of tryptophan to 3-hydroxy-anthranilate and tyrosine 3-hydroxylase catalyzes the rate limiting step in catecholamine biosynthesis: the conversion of tyrosine to 3,4-dihydroxy-L-phenylalanine.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 4 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Aromatic aminoacid monoxygenases, catalytic and oligomerization domains domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 4 hidden Markov models representing the Aromatic aminoacid monoxygenases, catalytic and oligomerization domains superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]