SUPERFAMILY 1.75 HMM library and genome assignments server


Nitric oxide (NO) synthase oxygenase domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Nitric oxide (NO) synthase oxygenase domain [ 56511]
Superfamily:   Nitric oxide (NO) synthase oxygenase domain [ 56512]
Families:   Nitric oxide (NO) synthase oxygenase domain [ 56513]


Superfamily statistics
Genomes (333) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 555 0 31
Proteins 539 0 31


Functional annotation
General category Metabolism
Detailed category Redox

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 7.29e-06 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.0006965 Least Informative Direct
Biological Process (BP) response to stimulus 1.855e-07 Least Informative Direct
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.0544 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.00154 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.4794 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.2215 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.02665 Least Informative Inherited
Biological Process (BP) cellular protein modification process 4.533e-13 Moderately Informative Direct
Biological Process (BP) regulation of localization 6.658e-05 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 9.067e-15 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0.0001835 Moderately Informative Direct
Biological Process (BP) multi-organism process 1.761e-14 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.004433 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.08406 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.003253 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.1785 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.08833 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.00195 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.3193 Moderately Informative Inherited
Biological Process (BP) system process 0.00389 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.03678 Moderately Informative Inherited
Biological Process (BP) muscle system process 0.0002532 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0 Informative Direct
Biological Process (BP) response to lipid 5.875e-06 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.000399 Informative Direct
Biological Process (BP) regulation of ion transport 7.61e-05 Informative Direct
Biological Process (BP) regulation of system process 8.185e-11 Informative Direct
Biological Process (BP) carboxylic acid catabolic process 9.5e-08 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.01749 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.004226 Informative Inherited
Biological Process (BP) response to other organism 0.0027 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.004205 Informative Inherited
Biological Process (BP) superoxide metabolic process 0 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0.0002493 Highly Informative Direct
Biological Process (BP) glutamine family amino acid catabolic process 7.281e-15 Highly Informative Direct
Biological Process (BP) response to lipopolysaccharide 0 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 2.673e-06 Highly Informative Direct
Biological Process (BP) regulation of calcium ion transport 0.05107 Highly Informative Inherited
Molecular Function (MF) binding 0.5389 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 1.042e-14 Moderately Informative Direct
Molecular Function (MF) anion binding 4.886e-05 Moderately Informative Direct
Molecular Function (MF) nucleotide binding 2.441e-06 Informative Direct
Molecular Function (MF) carboxylic acid binding 1.433e-10 Informative Direct
Molecular Function (MF) tetrapyrrole binding 9.468e-14 Informative Direct
Molecular Function (MF) cofactor binding 1.85e-09 Informative Direct
Molecular Function (MF) monooxygenase activity 0 Highly Informative Direct
Molecular Function (MF) amino acid binding 3.352e-12 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0 Highly Informative Direct
Molecular Function (MF) heme binding 6.487e-14 Highly Informative Direct
Molecular Function (MF) NADP binding 2.051e-07 Highly Informative Direct
Cellular Component (CC) membrane 0.07493 Least Informative Inherited
Cellular Component (CC) membrane raft 2.991e-08 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation0InformativeDirect
Enzyme Commission (EC)Nitric-oxide synthase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0Least InformativeDirect
Disease Ontology (DO)immune system disease0Least InformativeDirect
Disease Ontology (DO)nervous system disease0Least InformativeDirect
Disease Ontology (DO)disease of metabolism0Moderately InformativeDirect
Disease Ontology (DO)artery disease0Moderately InformativeDirect
Disease Ontology (DO)neurodegenerative disease0Moderately InformativeDirect
Disease Ontology (DO)disease of mental health0Moderately InformativeDirect
Disease Ontology (DO)musculoskeletal system disease0Moderately InformativeDirect
Disease Ontology (DO)urinary system disease0Moderately InformativeDirect
Disease Ontology (DO)syndrome0Moderately InformativeDirect
Disease Ontology (DO)nervous system cancer0Moderately InformativeDirect
Disease Ontology (DO)hypersensitivity reaction type II disease0Moderately InformativeDirect
Disease Ontology (DO)gastrointestinal system disease0Moderately InformativeDirect
Disease Ontology (DO)lung disease0Moderately InformativeDirect
Disease Ontology (DO)brain disease0Moderately InformativeDirect
Disease Ontology (DO)muscular disease0InformativeDirect
Disease Ontology (DO)hypertension0InformativeDirect
Disease Ontology (DO)nephritis0InformativeDirect
Disease Ontology (DO)peripheral nervous system neoplasm0InformativeDirect
Disease Ontology (DO)malaria0InformativeDirect
Disease Ontology (DO)asthma0InformativeDirect
Disease Ontology (DO)migraine0InformativeDirect
Disease Ontology (DO)glucose metabolism disease1InformativeInherited
Disease Ontology (DO)pre-eclampsia0Highly InformativeDirect
Disease Ontology (DO)Alzheimer's disease0Highly InformativeDirect
Disease Ontology (DO)autonomic nervous system neoplasm0Highly InformativeDirect
Disease Ontology (DO)chronic obstructive pulmonary disease0Highly InformativeDirect
Disease Ontology (DO)lupus erythematosus0Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body phenotype0Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)nervous system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)abnormal adaptive immunity0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cardiovascular development0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal reproductive system physiology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal heart morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)liver/biliary system phenotype0Moderately InformativeDirect
Mammalian Phenotype (MP)preweaning lethality0Moderately InformativeDirect
Mammalian Phenotype (MP)digestive/alimentary phenotype0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal blood vessel morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal hematopoietic cell number0Moderately InformativeDirect
Mammalian Phenotype (MP)muscle phenotype0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal immune cell physiology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal brain morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal reproductive system morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal skeleton morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal inflammatory response0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal hormone level0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal nervous system physiology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal eye morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal lipid homeostasis0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal professional antigen presenting cell morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal gland morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)renal/urinary system phenotype0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal protein level0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal neuron morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cell death0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cell-mediated immunity0Moderately InformativeDirect
Mammalian Phenotype (MP)respiratory system phenotype0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal blood cell physiology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal response to injury0InformativeDirect
Mammalian Phenotype (MP)abnormal trabecular bone morphology0InformativeDirect
Mammalian Phenotype (MP)premature death0InformativeDirect
Mammalian Phenotype (MP)abnormal renal glomerulus morphology0InformativeDirect
Mammalian Phenotype (MP)abnormal circulating lipoprotein level0InformativeDirect
Mammalian Phenotype (MP)abnormal fertility/fecundity0InformativeDirect
Mammalian Phenotype (MP)seizures0InformativeDirect
Mammalian Phenotype (MP)abnormal circulating leptin level0InformativeDirect
Mammalian Phenotype (MP)abnormal ion homeostasis0InformativeDirect
Mammalian Phenotype (MP)increased cholesterol level0InformativeDirect
Mammalian Phenotype (MP)abnormal circulating cholesterol level0InformativeDirect
Mammalian Phenotype (MP)impaired muscle contractility0InformativeDirect
Mammalian Phenotype (MP)abnormal macrophage physiology0InformativeDirect
Mammalian Phenotype (MP)abnormal circulating triglyceride level0InformativeDirect
Mammalian Phenotype (MP)abnormal urine homeostasis0InformativeDirect
Mammalian Phenotype (MP)abnormal skeleton physiology0InformativeDirect
Mammalian Phenotype (MP)abnormal urination0InformativeDirect
Mammalian Phenotype (MP)abnormal total tissue mass0InformativeDirect
Mammalian Phenotype (MP)abnormal consumption behavior0InformativeDirect
Mammalian Phenotype (MP)abnormal bone mineral density0InformativeDirect
Mammalian Phenotype (MP)abnormal circulating amino acid level0InformativeDirect
Mammalian Phenotype (MP)abnormal kidney physiology0InformativeDirect
Mammalian Phenotype (MP)abnormal systemic arterial blood pressure0InformativeDirect
Mammalian Phenotype (MP)abnormal stomach morphology0InformativeDirect
Mammalian Phenotype (MP)abnormal macrophage morphology0InformativeDirect
Mammalian Phenotype (MP)abnormal sensitivity to induced morbidity/mortality0InformativeDirect
Mammalian Phenotype (MP)abnormal triglyceride level0InformativeDirect
Mammalian Phenotype (MP)abnormal heart ventricle morphology0InformativeDirect
Mammalian Phenotype (MP)increased apoptosis0InformativeDirect
Mammalian Phenotype (MP)abnormal learning/memory/conditioning0InformativeDirect
Mammalian Phenotype (MP)abnormal white adipose tissue morphology0InformativeDirect
Mammalian Phenotype (MP)abnormal enzyme/ coenzyme level0InformativeDirect
Mammalian Phenotype (MP)abnormal fluid regulation0InformativeDirect
Mammalian Phenotype (MP)abnormal adipose tissue amount0InformativeDirect
Mammalian Phenotype (MP)abnormal blood vessel physiology0InformativeDirect
Mammalian Phenotype (MP)increased hematopoietic cell number0InformativeDirect
Mammalian Phenotype (MP)abnormal heartbeat0InformativeDirect
Mammalian Phenotype (MP)arteriosclerosis0InformativeDirect
Mammalian Phenotype (MP)abnormal sex gland morphology0InformativeDirect
Mammalian Phenotype (MP)abnormal female reproductive system physiology0InformativeDirect
Mammalian Phenotype (MP)abnormal blood coagulation0InformativeDirect
Mammalian Phenotype (MP)abnormal angiogenesis0InformativeDirect
Mammalian Phenotype (MP)abnormal gas homeostasis0InformativeDirect
Mammalian Phenotype (MP)abnormal internal female genitalia morphology0InformativeDirect
Mammalian Phenotype (MP)abnormal circulating glucose level0InformativeDirect
Mammalian Phenotype (MP)abnormal lung morphology0InformativeDirect
Mammalian Phenotype (MP)abnormal ovulation cycle0Highly InformativeDirect
Mammalian Phenotype (MP)abnormal skeleton development0Highly InformativeDirect
Mammalian Phenotype (MP)hypertension0Highly InformativeDirect
Mammalian Phenotype (MP)glomerular capillary thrombosis0Highly InformativeDirect
Mammalian Phenotype (MP)decreased heart rate0Highly InformativeDirect
Mammalian Phenotype (MP)abnormal nitric oxide homeostasis0Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating alkaline phosphatase level0Highly InformativeDirect
Mammalian Phenotype (MP)abnormal coronary artery morphology0Highly InformativeDirect
Mammalian Phenotype (MP)thick ventricular wall0Highly InformativeDirect
Mammalian Phenotype (MP)abnormal vascular wound healing0Highly InformativeDirect
Mammalian Phenotype (MP)decreased cardiac muscle contractility0Highly InformativeDirect
Mammalian Phenotype (MP)decreased adiponectin level0Highly InformativeDirect
Mammalian Phenotype (MP)increased bone mineral density0Highly InformativeDirect
Mammalian Phenotype (MP)pulmonary vascular congestion0Highly InformativeDirect
Mammalian Phenotype (MP)increased white adipose tissue amount0Highly InformativeDirect
Mammalian Phenotype (MP)increased systemic arterial systolic blood pressure0Highly InformativeDirect
Mammalian Phenotype (MP)increased blood urea nitrogen level0Highly InformativeDirect
Mammalian Phenotype (MP)increased prostaglandin level0Highly InformativeDirect
Mammalian Phenotype (MP)enlarged stomach0Highly InformativeDirect
Mammalian Phenotype (MP)increased body weight0Highly InformativeDirect
Mammalian Phenotype (MP)glomerulosclerosis0Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart ventricle pressure0Highly InformativeDirect
Mammalian Phenotype (MP)decreased urine sodium level0Highly InformativeDirect
Mammalian Phenotype (MP)renal tubular necrosis0Highly InformativeDirect
Mammalian Phenotype (MP)abnormal seizure response to inducing agent0Highly InformativeDirect
Mammalian Phenotype (MP)perivascular fibrosis0Highly InformativeDirect
Mammalian Phenotype (MP)decreased survivor rate0Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating LDL cholesterol level0Highly InformativeDirect
Mammalian Phenotype (MP)liver vascular congestion0Highly InformativeDirect
Mammalian Phenotype (MP)polydipsia0Highly InformativeDirect
Mammalian Phenotype (MP)abnormal vascular endothelial cell physiology0Highly InformativeDirect
Mammalian Phenotype (MP)partial prenatal lethality0Highly InformativeDirect
Mammalian Phenotype (MP)increased blood osmolality0Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating triglyceride level0Highly InformativeDirect
Mammalian Phenotype (MP)reduced fertility0Highly InformativeDirect
Mammalian Phenotype (MP)abnormal bone mineralization0Highly InformativeDirect
Mammalian Phenotype (MP)increased renal tubule apoptosis0Highly InformativeDirect
Mammalian Phenotype (MP)increased osteoclast cell number0Highly InformativeDirect
Mammalian Phenotype (MP)abnormal bone remodeling0Highly InformativeDirect
Mammalian Phenotype (MP)decreased systemic arterial blood pressure0Highly InformativeDirect
Mammalian Phenotype (MP)pyloric sphincter hypertrophy0Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating creatinine level0Highly InformativeDirect
Mammalian Phenotype (MP)congestive heart failure0Highly InformativeDirect
Mammalian Phenotype (MP)polyuria0Highly InformativeDirect

Document: MP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen0InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentMembrane0.002125Least InformativeInherited
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentGolgi apparatus2.413e-11Moderately InformativeDirect
Cellular componentCytoskeleton7.526e-10Moderately InformativeDirect
Cellular componentCell membrane1.805e-06Moderately InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionFlavoprotein0Moderately InformativeDirect
Molecular functionIron0Moderately InformativeDirect
Molecular functionCalcium4.804e-15Moderately InformativeDirect
Molecular functionCalmodulin-binding0InformativeDirect
Molecular functionFAD0InformativeDirect
Molecular functionFMN0InformativeDirect
Molecular functionHeme0InformativeDirect
Molecular functionNADP0InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationPalmitate2.796e-08Moderately InformativeDirect
Post-translational modificationMyristate4.217e-11InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR004030 SSF56512 Protein matches
Abstract

Nitric oxide synthase (NOS) enzymes produce nitric oxide (NO) by catalyzing a five-electron oxidation of a guanidino nitrogen of L-arginine (L-Arg). Oxidation of L-Arg to L-citrulline occurs via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine as an intermediate. 2 mol of O(2) and 1.5 mol of NADPH are consumed per mole of NO formed [PubMed8782597].

Arginine-derived NO synthesis has been identified in mammals, fish, birds, invertebrates, plants, and bacteria [PubMed8782597]. Best studied are mammals, where three distinct genes encode NOS isozymes: neuronal (nNOS or NOS-1), cytokine-inducible (iNOS or NOS-2) and endothelial (eNOS or NOS-3) [PubMed7510950]. iNOS and nNOS are soluble and found predominantly in the cytosol, while eNOS is membrane associated. The enzymes exist as homodimers, each monomer consisting of two major domains: an N-terminal oxygenase domain, which belongs to the class of heme-thiolate proteins, and a C-terminal reductase domain, which is homologous to NADPH:P450 reductase . The interdomain linker between the oxygenase and reductase domains contains a calmodulin (CaM)-binding sequence. NOSs are the only enzymes known to simultaneously require five bound cofactors animal NOS isozymes are catalytically self-sufficient. The electron flow in the NO synthase reaction is: NADPH --> FAD --> FMN --> heme --> O(2).

eNOS localisation to endothelial membranes is mediated by cotranslational N-terminal myristoylation and post-translational palmitoylation [PubMed9199168]. The subcellular localisation of nNOS in skeletal muscle is mediated by anchoring of nNOS to dystrophin. nNOS contains an additional N-terminal domain, the PDZ domain [PubMed7535955]. Some bacteria, like Bacillus halodurans, Bacillus subtilis or Deinococcus radiodurans, contain homologs of NOS oxygenase domain. The pattern is directed against the N-terminal heme binding site.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Nitric oxide (NO) synthase oxygenase domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the Nitric oxide (NO) synthase oxygenase domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]