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Fibrinogen C-terminal domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Fibrinogen C-terminal domain-like [ 56495]
Superfamily:   Fibrinogen C-terminal domain-like [ 56496]
Families:   Fibrinogen C-terminal domain-like [ 56497] (2)


Superfamily statistics
Genomes (175) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 5,719 7,075 21
Proteins 5,527 6,914 21


Functional annotation
General category Processes_EC
Detailed category Blood clotting

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Cellular Component (CC)extracellular matrix0.00000021090InformativeDirect
Cellular Component (CC)extracellular matrix part0.0000000068660.00000000001584Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0.0000000000287 Least Informative Direct
Biological Process (BP) developmental process 0.00000001927 Least Informative Direct
Biological Process (BP) response to stimulus 0.000000008443 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.00000148 Least Informative Direct
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.762 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.009776 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.5459 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.6209 Least Informative Inherited
Biological Process (BP) cell differentiation 0.000009318 Moderately Informative Direct
Biological Process (BP) organ development 0.9949 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.03591 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.02033 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.9722 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.1089 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.02038 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.001183 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.01335 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.997 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.1751 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.002346 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.8605 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.07201 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.5349 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.9898 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.9313 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.2292 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.00218 Moderately Informative Inherited
Biological Process (BP) tissue development 0.06829 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.1901 Moderately Informative Inherited
Biological Process (BP) immune system process 0.00231 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.03465 Moderately Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.00001366 Informative Direct
Biological Process (BP) phospholipid metabolic process 0.0002814 Informative Direct
Biological Process (BP) response to wounding 0.000000002361 Informative Direct
Biological Process (BP) regulation of intracellular protein kinase cascade 0.0000172 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.00007241 Informative Direct
Biological Process (BP) biological adhesion 0 Informative Direct
Biological Process (BP) cell projection organization 0.00000007627 Informative Direct
Biological Process (BP) generation of neurons 0.000000002874 Informative Direct
Biological Process (BP) regulation of body fluid levels 0.000001535 Informative Direct
Biological Process (BP) negative regulation of cell death 0.000004748 Informative Direct
Biological Process (BP) regulation of protein localization 0.03277 Informative Inherited
Biological Process (BP) cardiovascular system development 0.003536 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.1185 Informative Inherited
Biological Process (BP) regulation of secretion 0.02777 Informative Inherited
Biological Process (BP) positive regulation of transport 0.009235 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.03061 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.6687 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.468 Informative Inherited
Biological Process (BP) regulation of cell development 0.06092 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.001469 Informative Inherited
Biological Process (BP) glycerolipid metabolic process 0.001058 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.05551 Informative Inherited
Biological Process (BP) epithelium development 0.8542 Informative Inherited
Biological Process (BP) immune response 0.4015 Informative Inherited
Biological Process (BP) immune effector process 0.09714 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.09749 Informative Inherited
Biological Process (BP) defense response 0.9402 Informative Inherited
Biological Process (BP) regulation of immune response 0.06944 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.2844 Informative Inherited
Biological Process (BP) angiogenesis 0.0001345 Highly Informative Direct
Biological Process (BP) acylglycerol metabolic process 0.00000000834 Highly Informative Direct
Biological Process (BP) humoral immune response 0.0001184 Highly Informative Direct
Biological Process (BP) cell adhesion 0 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.000001757 Highly Informative Direct
Biological Process (BP) hemostasis 0.000000000003828 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.0006442 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0.00000000000001086 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0 Highly Informative Direct
Biological Process (BP) neuron projection development 0.0000000000007041 Highly Informative Direct
Biological Process (BP) cell part morphogenesis 0.0007667 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic process 0.00000006949 Highly Informative Direct
Biological Process (BP) positive regulation of protein secretion 0.00007016 Highly Informative Direct
Biological Process (BP) coagulation 0.00000002287 Highly Informative Direct
Biological Process (BP) protein activation cascade 0.0000000001326 Highly Informative Direct
Biological Process (BP) renal system development 0.02081 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.001936 Highly Informative Inherited
Biological Process (BP) regulation of angiogenesis 0.002372 Highly Informative Inherited
Biological Process (BP) regulation of MAP kinase activity 0.1095 Highly Informative Inherited
Biological Process (BP) response to axon injury 0.01006 Highly Informative Inherited
Biological Process (BP) innate immune response 0.03619 Highly Informative Inherited
Molecular Function (MF) binding 0.000002465 Least Informative Direct
Molecular Function (MF) enzyme regulator activity 0.0001954 Moderately Informative Direct
Molecular Function (MF) anion binding 0.02944 Moderately Informative Inherited
Molecular Function (MF) receptor binding 0 Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.000000000000003078 Informative Direct
Molecular Function (MF) sulfur compound binding 0.0000001641 Informative Direct
Molecular Function (MF) heparin binding 0.000000003759 Highly Informative Direct
Molecular Function (MF) protein complex binding 0.000002501 Highly Informative Direct
Molecular Function (MF) cytokine receptor binding 0.2486 Highly Informative Inherited
Molecular Function (MF) growth factor receptor binding 0.03817 Highly Informative Inherited
Cellular Component (CC) protein complex 0.7178 Least Informative Inherited
Cellular Component (CC) membrane 0.3652 Least Informative Inherited
Cellular Component (CC) vesicle 0.00009175 Moderately Informative Direct
Cellular Component (CC) cell projection 0.00002556 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 0.9619 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 0.3266 Moderately Informative Inherited
Cellular Component (CC) cell surface 0.000000004279 Informative Direct
Cellular Component (CC) extracellular matrix 0 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 0.00000005432 Informative Direct
Cellular Component (CC) neuron projection 0.07026 Informative Inherited
Cellular Component (CC) integral to membrane 0.2558 Informative Inherited
Cellular Component (CC) intrinsic to plasma membrane 0.5265 Informative Inherited
Cellular Component (CC) extracellular space 0.02508 Informative Inherited
Cellular Component (CC) proteinaceous extracellular matrix 0.000001639 Highly Informative Direct
Cellular Component (CC) ion channel complex 0.00008441 Highly Informative Direct
Cellular Component (CC) main axon 0.0000000001741 Highly Informative Direct
Cellular Component (CC) extracellular matrix part 0.00000000001584 Highly Informative Direct
Cellular Component (CC) integral to plasma membrane 0.07645 Highly Informative Inherited

Document: GO annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)anatomical group0Least InformativeDirect
Fly Anatomy (FA)external sensory organ0Moderately InformativeDirect
Fly Anatomy (FA)sensillum0Moderately InformativeDirect
Fly Anatomy (FA)chaeta0InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0Moderately InformativeDirect
Biological processAngiogenesis0InformativeDirect
Biological processCell adhesion0InformativeDirect
Biological processHemostasis0InformativeDirect
Biological processInnate immunity0.00000000000006762InformativeDirect
Biological processBlood coagulation0Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentExtracellular matrix0.00000005233InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainCoiled coil0Moderately InformativeDirect
DomainEGF-like domain0InformativeDirect
DomainCollagen0.00000000000005905Highly InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionLectin0InformativeDirect
Molecular functionChitin-binding0.0000000000006925Highly InformativeDirect
Post-translational modificationDevelopmental protein0.000000000000001548Moderately InformativeDirect
Post-translational modificationToxin0.00237InformativeInherited
Post-translational modificationHemostasis impairing toxin0.0000003341Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationHydroxylation0.000003734InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR002181 SSF56496 Protein matches
Abstract

This entry represents the C-terminal globular D domain of the alpha, beta and gamma chains. These domains are related to domains in other proteins: in the Parastichopus parvimensis (Sea cucumber) fibrogen-like FreP-A and FreP-B proteins; in the C-terminus of the Drosophila scabrous protein that is involved in the regulation of neurogenesis, possibly through the inhibition of R8 cell differentiation; and in ficolin proteins, which display lectin activity towards N-acetylglucosamine through their fibrogen-like domains [PubMed12396010].

More information about these proteins can be found at Protein of the Month: Fibrinogen.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Fibrinogen C-terminal domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the Fibrinogen C-terminal domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]