SUPERFAMILY 1.75 HMM library and genome assignments server


Fibrinogen C-terminal domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Fibrinogen C-terminal domain-like [ 56495]
Superfamily:   Fibrinogen C-terminal domain-like [ 56496]
Families:   Fibrinogen C-terminal domain-like [ 56497] (2)


Superfamily statistics
Genomes (152) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 5,124 5,976 21
Proteins 4,962 5,845 21


Functional annotation
General category Processes_EC
Detailed category Blood clotting

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Cellular Component (CC)extracellular region0.0064740Moderately InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 0.0002499 Least Informative Direct
Biological Process (BP) multicellular organismal process 5.007e-08 Least Informative Direct
Biological Process (BP) developmental process 2.871e-07 Least Informative Direct
Biological Process (BP) response to stimulus 5.328e-05 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 6.913e-05 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.2614 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.896 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.7807 Least Informative Inherited
Biological Process (BP) cell differentiation 3.838e-06 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.1011 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.4129 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.7046 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.01201 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.8973 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.05157 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.2434 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.001429 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.284 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.2925 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.3395 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.003199 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.1038 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.9444 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.02332 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.1338 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.8338 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 0.01348 Moderately Informative Inherited
Biological Process (BP) tissue development 0.1709 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.03041 Moderately Informative Inherited
Biological Process (BP) biological adhesion 0 Informative Direct
Biological Process (BP) generation of neurons 1.785e-09 Informative Direct
Biological Process (BP) response to wounding 3.265e-09 Informative Direct
Biological Process (BP) cell projection organization 2.089e-07 Informative Direct
Biological Process (BP) regulation of protein phosphorylation 7.147e-06 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 9.785e-05 Informative Direct
Biological Process (BP) regulation of body fluid levels 0.000158 Informative Direct
Biological Process (BP) phospholipid metabolic process 0.0003121 Informative Direct
Biological Process (BP) cardiovascular system development 0.001813 Informative Inherited
Biological Process (BP) negative regulation of molecular function 0.2466 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.6712 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.01908 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.002161 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.07555 Informative Inherited
Biological Process (BP) regulation of response to stress 0.03461 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.7433 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.001202 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.01168 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.001995 Informative Inherited
Biological Process (BP) regulation of locomotion 0.004819 Informative Inherited
Biological Process (BP) glycerolipid metabolic process 0.001032 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.04173 Informative Inherited
Biological Process (BP) epithelium development 0.5041 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.2412 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.04012 Informative Inherited
Biological Process (BP) cell adhesion 4.008e-15 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 3.161e-13 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 2.115e-10 Highly Informative Direct
Biological Process (BP) acylglycerol metabolic process 1.042e-08 Highly Informative Direct
Biological Process (BP) hemostasis 4e-08 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 3.18e-06 Highly Informative Direct
Biological Process (BP) coagulation 7.545e-06 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.0001628 Highly Informative Direct
Biological Process (BP) angiogenesis 0.0001709 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic process 0.0002184 Highly Informative Direct
Biological Process (BP) regulation of angiogenesis 0.0002359 Highly Informative Direct
Biological Process (BP) kidney development 0.001476 Highly Informative Inherited
Biological Process (BP) cell fate commitment 0.2628 Highly Informative Inherited
Biological Process (BP) regulation of MAP kinase activity 0.009098 Highly Informative Inherited
Biological Process (BP) response to axon injury 0.006366 Highly Informative Inherited
Biological Process (BP) axonogenesis 0.2922 Highly Informative Inherited
Molecular Function (MF) binding 0.0001 Least Informative Direct
Molecular Function (MF) enzyme regulator activity 0.0003002 Moderately Informative Direct
Molecular Function (MF) anion binding 0.07536 Moderately Informative Inherited
Molecular Function (MF) protein binding 0.2879 Moderately Informative Inherited
Molecular Function (MF) receptor binding 3.37e-13 Informative Direct
Molecular Function (MF) sulfur compound binding 6.353e-08 Highly Informative Direct
Molecular Function (MF) protein complex binding 1.06e-06 Highly Informative Direct
Molecular Function (MF) glycosaminoglycan binding 0.6552 Highly Informative Inherited
Cellular Component (CC) protein complex 0.7978 Least Informative Inherited
Cellular Component (CC) membrane 0.9883 Least Informative Inherited
Cellular Component (CC) extracellular region 0 Moderately Informative Direct
Cellular Component (CC) cell projection 1.464e-05 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 0.8421 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 0.6255 Moderately Informative Inherited
Cellular Component (CC) extracellular matrix 0 Informative Direct
Cellular Component (CC) cell surface 9.835e-07 Informative Direct
Cellular Component (CC) neuron part 4.204e-05 Informative Direct
Cellular Component (CC) cell projection part 5.885e-05 Informative Direct
Cellular Component (CC) integral to membrane 0.2999 Informative Inherited
Cellular Component (CC) intrinsic to plasma membrane 0.2642 Informative Inherited
Cellular Component (CC) extracellular space 0.9398 Informative Inherited
Cellular Component (CC) extracellular matrix part 7.09e-10 Highly Informative Direct
Cellular Component (CC) axon part 0.0001 Highly Informative Direct
Cellular Component (CC) proteinaceous extracellular matrix 0.0003937 Highly Informative Direct
Cellular Component (CC) integral to plasma membrane 0.07353 Highly Informative Inherited

Document: GO annotation of SCOP domains

Human Phenotype (HP)

(show details) Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality during development0Least InformativeDirect
Fly Phenotype (FP)partially lethal - majority die0Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)sense organ0Moderately InformativeDirect
Fly Anatomy (FA)cell cluster organ0Moderately InformativeDirect
Fly Anatomy (FA)chaeta0InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)embryonic stage0.01452Least InformativeInherited
Xenopus DEvelopment stage (XDE)tailbud stage0.1743Moderately InformativeInherited
Xenopus DEvelopment stage (XDE)NF stage 250.0004159Highly InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0Moderately InformativeDirect
Biological processAngiogenesis0InformativeDirect
Biological processCell adhesion0InformativeDirect
Biological processHemostasis0InformativeDirect
Biological processInnate immunity0InformativeDirect
Biological processBlood coagulation0Highly InformativeDirect
Cellular componentMembrane0.8443Least InformativeInherited
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentExtracellular matrix6.019e-08InformativeDirect
DomainSignal0Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainEGF-like domain0InformativeDirect
DomainCollagen1.325e-13Highly InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionLectin0InformativeDirect
Molecular functionChitin-binding3.279e-13Highly InformativeDirect
Post-translational modificationDevelopmental protein1.32e-15Moderately InformativeDirect
Post-translational modificationToxin0.001947InformativeInherited
Post-translational modificationHemostasis impairing toxin2.093e-07Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationHydroxylation2.81e-05InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR002181 SSF56496 Protein matches
Abstract

This entry represents the C-terminal globular D domain of the alpha, beta and gamma chains. These domains are related to domains in other proteins: in the Parastichopus parvimensis (Sea cucumber) fibrogen-like FreP-A and FreP-B proteins; in the C-terminus of the Drosophila scabrous protein that is involved in the regulation of neurogenesis, possibly through the inhibition of R8 cell differentiation; and in ficolin proteins, which display lectin activity towards N-acetylglucosamine through their fibrogen-like domains [PubMed12396010].

More information about these proteins can be found at Protein of the Month: Fibrinogen.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Human Phenotype (HP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Fibrinogen C-terminal domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the Fibrinogen C-terminal domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Human Phenotype (HP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]