SUPERFAMILY 1.75 HMM library and genome assignments server

Fibrinogen C-terminal domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Fibrinogen C-terminal domain-like [ 56495]
Superfamily:   Fibrinogen C-terminal domain-like [ 56496]
Families:   Fibrinogen C-terminal domain-like [ 56497] (2)


Superfamily statistics
Genomes (176) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 5,721 7,075 21
Proteins 5,529 6,914 21


Functional annotation
General category Processes_EC
Detailed category Blood clotting

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Cellular Component (CC)extracellular matrix0.00000019890InformativeDirect
Cellular Component (CC)extracellular matrix part0.000000004690.000000000006243Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0.00000000002095 Least Informative Direct
Biological Process (BP) developmental process 0.00000002048 Least Informative Direct
Biological Process (BP) response to stimulus 0.000000009203 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.000001002 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.9882 Least Informative Inherited
Biological Process (BP) positive regulation of biological process 0.008881 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.6044 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.3817 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.84 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.6429 Least Informative Inherited
Biological Process (BP) cell differentiation 0.00001132 Moderately Informative Direct
Biological Process (BP) regulation of phosphorus metabolic process 0.0002534 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.5347 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.04341 Moderately Informative Inherited
Biological Process (BP) organ development 0.9713 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.8535 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.02316 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.1231 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.002391 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.8642 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.00971 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.0814 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.1159 Moderately Informative Inherited
Biological Process (BP) tissue development 0.0687 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.3409 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.002175 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.9789 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.2549 Moderately Informative Inherited
Biological Process (BP) immune system process 0.002337 Moderately Informative Inherited
Biological Process (BP) defense response 0.8904 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.07492 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.1895 Moderately Informative Inherited
Biological Process (BP) phospholipid metabolic process 0.0002857 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.0000651 Informative Direct
Biological Process (BP) biological adhesion 0 Informative Direct
Biological Process (BP) cell projection organization 0.000000003787 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.00007054 Informative Direct
Biological Process (BP) generation of neurons 0.000000003058 Informative Direct
Biological Process (BP) regulation of body fluid levels 0.000001477 Informative Direct
Biological Process (BP) negative regulation of cell death 0.00001408 Informative Direct
Biological Process (BP) regulation of secretion 0.02761 Informative Inherited
Biological Process (BP) regulation of protein localization 0.03387 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.01406 Informative Inherited
Biological Process (BP) cardiovascular system development 0.00371 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.001459 Informative Inherited
Biological Process (BP) regulation of MAPK cascade 0.006896 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.08552 Informative Inherited
Biological Process (BP) regulation of transferase activity 0.3307 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.537 Informative Inherited
Biological Process (BP) regulation of cell development 0.04308 Informative Inherited
Biological Process (BP) immune response 0.3995 Informative Inherited
Biological Process (BP) glycerolipid metabolic process 0.001069 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.05029 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) immune effector process 0.09806 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.1473 Informative Inherited
Biological Process (BP) regulation of immune response 0.06862 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.2888 Informative Inherited
Biological Process (BP) angiogenesis 0.0001957 Highly Informative Direct
Biological Process (BP) acylglycerol metabolic process 0.000000008226 Highly Informative Direct
Biological Process (BP) humoral immune response 0.0001173 Highly Informative Direct
Biological Process (BP) cell adhesion 0 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.000001733 Highly Informative Direct
Biological Process (BP) hemostasis 0.00000000000365 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.0005975 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0.00000000000002422 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0 Highly Informative Direct
Biological Process (BP) neuron projection development 0.0000000000007511 Highly Informative Direct
Biological Process (BP) coagulation 0.00000002762 Highly Informative Direct
Biological Process (BP) protein activation cascade 0.00000000007365 Highly Informative Direct
Biological Process (BP) kidney development 0.00438 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.002807 Highly Informative Inherited
Biological Process (BP) regulation of protein serine/threonine kinase activity 0.2284 Highly Informative Inherited
Biological Process (BP) response to axon injury 0.03564 Highly Informative Inherited
Biological Process (BP) innate immune response 0.04568 Highly Informative Inherited
Molecular Function (MF) binding 0.000003219 Least Informative Direct
Molecular Function (MF) enzyme regulator activity 0.00003637 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.00000398 Moderately Informative Direct
Molecular Function (MF) anion binding 0.02943 Moderately Informative Inherited
Molecular Function (MF) receptor binding 0 Informative Direct
Molecular Function (MF) protein complex binding 0.0000005392 Informative Direct
Molecular Function (MF) sulfur compound binding 0.0000002729 Informative Direct
Molecular Function (MF) heparin binding 0.00000000381 Highly Informative Direct
Molecular Function (MF) cell adhesion molecule binding 0.000000000002401 Highly Informative Direct
Molecular Function (MF) cytokine receptor binding 0.2499 Highly Informative Inherited
Molecular Function (MF) growth factor receptor binding 0.03814 Highly Informative Inherited
Cellular Component (CC) protein complex 0.3029 Least Informative Inherited
Cellular Component (CC) membrane 0.3652 Least Informative Inherited
Cellular Component (CC) vesicle 0.0001008 Moderately Informative Direct
Cellular Component (CC) cell projection 0.00003434 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) intrinsic component of membrane 1 Moderately Informative Inherited
Cellular Component (CC) plasma membrane part 0.001843 Moderately Informative Inherited
Cellular Component (CC) cell surface 0.00000001095 Informative Direct
Cellular Component (CC) extracellular matrix 0 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 0.00000006727 Informative Direct
Cellular Component (CC) transporter complex 0.0002947 Informative Direct
Cellular Component (CC) extracellular space 0.02423 Informative Inherited
Cellular Component (CC) neuron projection 0.05553 Informative Inherited
Cellular Component (CC) integral component of membrane 0.9993 Informative Inherited
Cellular Component (CC) intrinsic component of plasma membrane 0.6691 Informative Inherited
Cellular Component (CC) proteinaceous extracellular matrix 0.000000608 Highly Informative Direct
Cellular Component (CC) ion channel complex 0.0008684 Highly Informative Direct
Cellular Component (CC) main axon 0.0000000001709 Highly Informative Direct
Cellular Component (CC) extracellular matrix part 0.000000000006243 Highly Informative Direct
Cellular Component (CC) integral component of plasma membrane 0.5776 Highly Informative Inherited

Document: GO annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)anatomical group0Least InformativeDirect
Fly Anatomy (FA)external sensory organ0Moderately InformativeDirect
Fly Anatomy (FA)sensillum0Moderately InformativeDirect
Fly Anatomy (FA)chaeta0InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)alimentary tract and metabolism0Least InformativeDirect
Drugbank ATC_code (DB)drugs for acid related disorders0InformativeDirect
Drugbank ATC_code (DB)sucralfate0Highly InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0Moderately InformativeDirect
Biological processAngiogenesis0InformativeDirect
Biological processCell adhesion0InformativeDirect
Biological processHemostasis0InformativeDirect
Biological processInnate immunity0.00000000000006762InformativeDirect
Biological processBlood coagulation0Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentExtracellular matrix0.00000005233InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainCoiled coil0Moderately InformativeDirect
DomainEGF-like domain0InformativeDirect
DomainCollagen0.00000000000005905Highly InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionLectin0InformativeDirect
Molecular functionChitin-binding0.0000000000006925Highly InformativeDirect
Post-translational modificationDevelopmental protein0.000000000000001548Moderately InformativeDirect
Post-translational modificationToxin0.00237InformativeInherited
Post-translational modificationHemostasis impairing toxin0.0000003341Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationHydroxylation0.000003734InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR002181 SSF56496 Protein matches
Abstract

This entry represents the C-terminal globular D domain of the alpha, beta and gamma chains. These domains are related to domains in other proteins: in the Parastichopus parvimensis (Sea cucumber) fibrogen-like FreP-A and FreP-B proteins; in the C-terminus of the Drosophila scabrous protein that is involved in the regulation of neurogenesis, possibly through the inhibition of R8 cell differentiation; and in ficolin proteins, which display lectin activity towards N-acetylglucosamine through their fibrogen-like domains [PubMed12396010].

More information about these proteins can be found at Protein of the Month: Fibrinogen.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Fibrinogen C-terminal domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the Fibrinogen C-terminal domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · Internal database links ]