SUPERFAMILY 1.75 HMM library and genome assignments server


SRCR-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   SRCR-like [ 56486] (2)
Superfamily:   SRCR-like [ 56487] (2)
Families:   Scavenger receptor cysteine-rich (SRCR) domain [ 56488]
  Hepsin, N-terminal domain [ 103355]


Superfamily statistics
Genomes (150) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 10,899 10,776 3
Proteins 3,763 3,568 3


Functional annotation
General category Regulation
Detailed category Receptor activity

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 8.738e-13 Least Informative Direct
Biological Process (BP) protein metabolic process 9.213e-12 Least Informative Direct
Biological Process (BP) multicellular organismal process 3.333e-07 Least Informative Direct
Biological Process (BP) response to stimulus 0.002073 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.2309 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.5856 Least Informative Inherited
Biological Process (BP) developmental process 0.01207 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.2169 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.02351 Least Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 2.531e-07 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 2.883e-07 Moderately Informative Direct
Biological Process (BP) system process 4.77e-07 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 1.194e-06 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 1.574e-06 Moderately Informative Direct
Biological Process (BP) multi-organism process 3.996e-05 Moderately Informative Direct
Biological Process (BP) regulation of programmed cell death 0.0001925 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.0003442 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.0006175 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0.5893 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.4858 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.1541 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.048 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.08356 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.6575 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.1253 Moderately Informative Inherited
Biological Process (BP) ion transport 0.03489 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.1507 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.1108 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.118 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.01353 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.1991 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.007531 Moderately Informative Inherited
Biological Process (BP) organ development 0.001132 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.4751 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.5948 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.06274 Moderately Informative Inherited
Biological Process (BP) metal ion transport 6.422e-12 Informative Direct
Biological Process (BP) proteolysis 1.749e-11 Informative Direct
Biological Process (BP) transmembrane transport 4.873e-08 Informative Direct
Biological Process (BP) positive regulation of protein metabolic process 8.015e-08 Informative Direct
Biological Process (BP) embryonic organ development 3.218e-07 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 5.009e-07 Informative Direct
Biological Process (BP) secretion by cell 3.249e-06 Informative Direct
Biological Process (BP) response to hormone stimulus 4.871e-05 Informative Direct
Biological Process (BP) sensory organ development 6.358e-05 Informative Direct
Biological Process (BP) embryonic morphogenesis 7.532e-05 Informative Direct
Biological Process (BP) regulation of growth 0.0001649 Informative Direct
Biological Process (BP) negative regulation of cell death 0.0001728 Informative Direct
Biological Process (BP) positive regulation of developmental process 0.0001888 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.0003012 Informative Direct
Biological Process (BP) single-organism behavior 0.0003179 Informative Direct
Biological Process (BP) negative regulation of developmental process 0.0004441 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.2139 Informative Inherited
Biological Process (BP) positive regulation of cell proliferation 0.005064 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.2927 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.404 Informative Inherited
Biological Process (BP) organ morphogenesis 0.01007 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.03719 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.01158 Informative Inherited
Biological Process (BP) negative regulation of gene expression 0.0596 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.5155 Informative Inherited
Biological Process (BP) regulation of cell development 1 Informative Inherited
Biological Process (BP) response to inorganic substance 0.06288 Informative Inherited
Biological Process (BP) cardiovascular system development 0.003136 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.04891 Informative Inherited
Biological Process (BP) locomotion 0.01215 Informative Inherited
Biological Process (BP) cellular component movement 0.06257 Informative Inherited
Biological Process (BP) localization of cell 0.2227 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.007996 Informative Inherited
Biological Process (BP) regulation of cellular amine metabolic process 0 Highly Informative Direct
Biological Process (BP) interaction with symbiont 0 Highly Informative Direct
Biological Process (BP) regulation of protein processing 0 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0 Highly Informative Direct
Biological Process (BP) modification of morphology or physiology of other organism involved in symbiotic interaction 1.773e-14 Highly Informative Direct
Biological Process (BP) ion transmembrane transport 4.102e-14 Highly Informative Direct
Biological Process (BP) positive regulation of epithelial cell proliferation 4.27e-14 Highly Informative Direct
Biological Process (BP) cellular component disassembly 6.655e-12 Highly Informative Direct
Biological Process (BP) embryonic organ morphogenesis 7.292e-12 Highly Informative Direct
Biological Process (BP) regulation of cellular ketone metabolic process 1.437e-11 Highly Informative Direct
Biological Process (BP) stem cell development 1.91e-11 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 4.331e-11 Highly Informative Direct
Biological Process (BP) regulation of multi-organism process 1.251e-10 Highly Informative Direct
Biological Process (BP) inner ear development 3.077e-10 Highly Informative Direct
Biological Process (BP) mesenchyme development 1.198e-09 Highly Informative Direct
Biological Process (BP) response to hypoxia 1.848e-09 Highly Informative Direct
Biological Process (BP) regulation of cell growth 1.039e-08 Highly Informative Direct
Biological Process (BP) angiogenesis 1.037e-07 Highly Informative Direct
Biological Process (BP) positive regulation of growth 3.213e-07 Highly Informative Direct
Biological Process (BP) protein processing 3.682e-07 Highly Informative Direct
Biological Process (BP) regulation of organ morphogenesis 1.408e-06 Highly Informative Direct
Biological Process (BP) cell proliferation 2.895e-06 Highly Informative Direct
Biological Process (BP) positive regulation of cell differentiation 3.273e-06 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 1.45e-05 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 1.554e-05 Highly Informative Direct
Biological Process (BP) negative regulation of transcription, DNA-dependent 8.682e-05 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 0.0001837 Highly Informative Direct
Biological Process (BP) exocytosis 0.00019 Highly Informative Direct
Biological Process (BP) monovalent inorganic cation transport 0.0003127 Highly Informative Direct
Biological Process (BP) sensory perception 0.0003746 Highly Informative Direct
Molecular Function (MF) hydrolase activity 5.744e-05 Least Informative Direct
Molecular Function (MF) binding 0.392 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0.0006828 Moderately Informative Direct
Molecular Function (MF) transporter activity 0.0007024 Moderately Informative Direct
Molecular Function (MF) peptidase activity 0 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 4.869e-10 Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 2.379e-08 Informative Direct
Molecular Function (MF) receptor activity 8.663e-06 Informative Direct
Molecular Function (MF) enzyme binding 0.002683 Informative Inherited
Molecular Function (MF) ion gated channel activity 5.947e-11 Highly Informative Direct
Molecular Function (MF) ion channel activity 9.273e-10 Highly Informative Direct
Molecular Function (MF) transcription factor binding transcription factor activity 0.002064 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.1427 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.5823 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.8981 Least Informative Inherited
Cellular Component (CC) plasma membrane part 1.662e-11 Moderately Informative Direct
Cellular Component (CC) extracellular region part 4.267e-10 Moderately Informative Direct
Cellular Component (CC) endomembrane system 5.698e-10 Moderately Informative Direct
Cellular Component (CC) organelle membrane 6.364e-07 Moderately Informative Direct
Cellular Component (CC) vesicle 6.73e-07 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 1.178e-06 Moderately Informative Direct
Cellular Component (CC) organelle envelope 5.041e-06 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.05538 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.02566 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 0.09902 Moderately Informative Inherited
Cellular Component (CC) extracellular matrix 0 Informative Direct
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) integral to membrane 1.312e-13 Informative Direct
Cellular Component (CC) nuclear envelope 4.301e-11 Informative Direct
Cellular Component (CC) cell-cell junction 9.851e-09 Informative Direct
Cellular Component (CC) endoplasmic reticulum membrane 1.1e-05 Informative Direct
Cellular Component (CC) intrinsic to plasma membrane 6.979e-05 Informative Direct
Cellular Component (CC) secretory granule 0.03239 Informative Inherited
Cellular Component (CC) neuron projection 0.9987 Informative Inherited
Cellular Component (CC) nuclear membrane 0 Highly Informative Direct
Cellular Component (CC) extracellular matrix part 7.969e-13 Highly Informative Direct
Cellular Component (CC) cell body 1.737e-10 Highly Informative Direct
Cellular Component (CC) cytoplasmic vesicle membrane 6.006e-06 Highly Informative Direct
Cellular Component (CC) proteinaceous extracellular matrix 7.604e-06 Highly Informative Direct
Cellular Component (CC) integral to plasma membrane 4.657e-05 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details) Document: HP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0.0001115Least InformativeDirect
Enzyme Commission (EC)Hydrolases0.0002211Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)7.332e-14Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH(2) group of donors0InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0InformativeDirect
Enzyme Commission (EC)With oxygen as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Enteropeptidase6.974e-11Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0.0001192Moderately InformativeDirect
Biological processCell adhesion3.562e-12InformativeDirect
Biological processInflammatory response4.644e-10InformativeDirect
Biological processAcute phase3.007e-14Highly InformativeDirect
Cellular componentMembrane2.633e-08Least InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.0002585Moderately InformativeDirect
Cellular componentExtracellular matrix2.89e-10InformativeDirect
Cellular componentChromosome3.369e-09InformativeDirect
Cellular componentBasement membrane0.0002346Highly InformativeDirect
DomainSignal0Least InformativeDirect
DomainRepeat9.275e-14Least InformativeDirect
DomainTransmembrane0.0004966Least InformativeDirect
DomainSignal-anchor0InformativeDirect
DomainKringle0Highly InformativeDirect
DomainCollagen6.321e-10Highly InformativeDirect
Molecular functionCopper0InformativeDirect
Post-translational modificationHydrolase1.032e-07Least InformativeDirect
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationReceptor4.108e-11Moderately InformativeDirect
Post-translational modificationRepressor4.384e-07Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.0001266Moderately InformativeDirect
Post-translational modificationSerine protease0InformativeDirect
Post-translational modificationChromatin regulator5.218e-12InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a SRCR-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the SRCR-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]