SUPERFAMILY 1.75 HMM library and genome assignments server

SRCR-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   SRCR-like [ 56486] (2)
Superfamily:   SRCR-like [ 56487] (2)
Families:   Scavenger receptor cysteine-rich (SRCR) domain [ 56488]
  Hepsin, N-terminal domain [ 103355]


Superfamily statistics
Genomes (166) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 12,110 12,352 3
Proteins 4,143 4,183 3


Functional annotation
General category Regulation
Detailed category Receptor activity

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 0.00000000000156 Least Informative Direct
Biological Process (BP) protein metabolic process 0.00000000002867 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.000000253 Least Informative Direct
Biological Process (BP) positive regulation of biological process 0.00007648 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.04847 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.2491 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.8363 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.001182 Least Informative Inherited
Biological Process (BP) developmental process 0.01088 Least Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.00000003262 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.0000006639 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.000004835 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.00001081 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.0009691 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.2973 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.03155 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.2183 Moderately Informative Inherited
Biological Process (BP) organ development 0.002791 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.06594 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.1804 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.381 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.04833 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.01322 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.09604 Moderately Informative Inherited
Biological Process (BP) tissue development 0.08198 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.06142 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.006553 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.001389 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.1605 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.1066 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.002464 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.02388 Moderately Informative Inherited
Biological Process (BP) ion transport 0.1919 Moderately Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.0000000000000406 Informative Direct
Biological Process (BP) metal ion transport 0.00000000001002 Informative Direct
Biological Process (BP) proteolysis 0.00000000002078 Informative Direct
Biological Process (BP) ion transmembrane transport 0.00000000002332 Informative Direct
Biological Process (BP) embryonic organ development 0.0000001968 Informative Direct
Biological Process (BP) secretion by cell 0.0000002962 Informative Direct
Biological Process (BP) cell proliferation 0.0000004135 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.000003449 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.000004713 Informative Direct
Biological Process (BP) embryonic morphogenesis 0.00003247 Informative Direct
Biological Process (BP) sensory organ development 0.00003726 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.0001086 Informative Direct
Biological Process (BP) regulation of growth 0.0001685 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.000326 Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.0004259 Informative Direct
Biological Process (BP) positive regulation of gene expression 0.5385 Informative Inherited
Biological Process (BP) neurological system process 0.001586 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.2588 Informative Inherited
Biological Process (BP) cardiovascular system development 0.003789 Informative Inherited
Biological Process (BP) response to inorganic substance 0.06414 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.08115 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.04289 Informative Inherited
Biological Process (BP) positive regulation of RNA metabolic process 0.1781 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.2814 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.001663 Informative Inherited
Biological Process (BP) organ morphogenesis 0.006918 Informative Inherited
Biological Process (BP) protein maturation 0.001865 Informative Inherited
Biological Process (BP) regulation of cell development 0.9833 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.002121 Informative Inherited
Biological Process (BP) localization of cell 0.2343 Informative Inherited
Biological Process (BP) locomotion 0.01511 Informative Inherited
Biological Process (BP) cellular component movement 0.01646 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.4568 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.0072 Informative Inherited
Biological Process (BP) single-organism behavior 0.001904 Informative Inherited
Biological Process (BP) monovalent inorganic cation transport 0.003156 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.06287 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.01039 Informative Inherited
Biological Process (BP) extracellular matrix organization 0 Highly Informative Direct
Biological Process (BP) regulation of cellular amine metabolic process 0 Highly Informative Direct
Biological Process (BP) positive regulation of epithelial cell proliferation 0.00000000000004551 Highly Informative Direct
Biological Process (BP) cellular component disassembly 0.0000000000002995 Highly Informative Direct
Biological Process (BP) modification of morphology or physiology of other organism 0.000000000002281 Highly Informative Direct
Biological Process (BP) embryonic organ morphogenesis 0.000000000009446 Highly Informative Direct
Biological Process (BP) regulation of cellular ketone metabolic process 0.00000000001055 Highly Informative Direct
Biological Process (BP) stem cell development 0.00000000003483 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.0000000000564 Highly Informative Direct
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.0000000012 Highly Informative Direct
Biological Process (BP) regulation of multi-organism process 0.000000002201 Highly Informative Direct
Biological Process (BP) mesenchyme development 0.000000006054 Highly Informative Direct
Biological Process (BP) response to hypoxia 0.00000001665 Highly Informative Direct
Biological Process (BP) angiogenesis 0.0000000395 Highly Informative Direct
Biological Process (BP) positive regulation of growth 0.0000002879 Highly Informative Direct
Biological Process (BP) learning or memory 0.0000004561 Highly Informative Direct
Biological Process (BP) regulation of organ morphogenesis 0.00000141 Highly Informative Direct
Biological Process (BP) ear development 0.000001693 Highly Informative Direct
Biological Process (BP) response to transition metal nanoparticle 0.00000589 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0.00002067 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0.00003207 Highly Informative Direct
Biological Process (BP) negative regulation of transcription, DNA-templated 0.0001436 Highly Informative Direct
Biological Process (BP) exocytosis 0.0001834 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 0.0008931 Highly Informative Direct
Biological Process (BP) sensory perception 0.1488 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0.00005241 Least Informative Direct
Molecular Function (MF) binding 0.4216 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0.0006257 Moderately Informative Direct
Molecular Function (MF) transporter activity 0.001024 Moderately Informative Inherited
Molecular Function (MF) peptidase activity 0 Informative Direct
Molecular Function (MF) monovalent inorganic cation transmembrane transporter activity 0.0000000001532 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0.0000000007061 Informative Direct
Molecular Function (MF) receptor activity 0.000009483 Informative Direct
Molecular Function (MF) enzyme binding 0.004877 Informative Inherited
Molecular Function (MF) serine hydrolase activity 0 Highly Informative Direct
Molecular Function (MF) cation channel activity 0.00000000005191 Highly Informative Direct
Molecular Function (MF) gated channel activity 0.000000000105 Highly Informative Direct
Molecular Function (MF) transcription factor binding transcription factor activity 0.002251 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.6904 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.1629 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.987 Least Informative Inherited
Cellular Component (CC) bounding membrane of organelle 0.0000000000005833 Moderately Informative Direct
Cellular Component (CC) plasma membrane part 0.00000000004456 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.00000000007163 Moderately Informative Direct
Cellular Component (CC) vesicle 0.000000142 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 0.000001857 Moderately Informative Direct
Cellular Component (CC) organelle envelope 0.000007426 Moderately Informative Direct
Cellular Component (CC) cell projection 0.03285 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 0.0811 Moderately Informative Inherited
Cellular Component (CC) membrane region 0.05994 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.05635 Moderately Informative Inherited
Cellular Component (CC) extracellular matrix 0 Informative Direct
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) nuclear envelope 0.00000000002386 Informative Direct
Cellular Component (CC) cell junction 0.0000002015 Informative Direct
Cellular Component (CC) endoplasmic reticulum membrane 0.000009709 Informative Direct
Cellular Component (CC) intrinsic component of plasma membrane 0.00003636 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 0.0007142 Informative Direct
Cellular Component (CC) secretory granule 0.007232 Informative Inherited
Cellular Component (CC) neuron projection 0.9566 Informative Inherited
Cellular Component (CC) integral component of membrane 0.02985 Informative Inherited
Cellular Component (CC) nuclear membrane 0.00000000000003545 Highly Informative Direct
Cellular Component (CC) extracellular matrix part 0.0000000000005736 Highly Informative Direct
Cellular Component (CC) cell body 0.000000000153 Highly Informative Direct
Cellular Component (CC) cytoplasmic vesicle membrane 0.000001998 Highly Informative Direct
Cellular Component (CC) proteinaceous extracellular matrix 0.000005356 Highly Informative Direct
Cellular Component (CC) integral component of plasma membrane 0.00001027 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)viral infectious disease0.1318InformativeInherited

Document: DO annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0.0001034Least InformativeDirect
Enzyme Commission (EC)Hydrolases0.0002113Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.00000000000006211Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH(2) group of donors0InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0InformativeDirect
Enzyme Commission (EC)With oxygen as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Enteropeptidase0.00000000006937Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0.000129Moderately InformativeDirect
Biological processCell adhesion0.000000000003763InformativeDirect
Biological processInflammatory response0.0000000005721InformativeDirect
Biological processAcute phase0.000000000000029Highly InformativeDirect
Cellular componentMembrane0.00000002407Least InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.0002844Moderately InformativeDirect
Cellular componentExtracellular matrix0.000000000246InformativeDirect
Cellular componentChromosome0.000000003578InformativeDirect
Cellular componentBasement membrane0.0002426Highly InformativeDirect
DomainSignal0Least InformativeDirect
DomainRepeat0.00000000000009048Least InformativeDirect
DomainTransmembrane0.0004525Least InformativeDirect
DomainSignal-anchor0InformativeDirect
DomainKringle0Highly InformativeDirect
DomainCollagen0.000000000593Highly InformativeDirect
Molecular functionCopper0InformativeDirect
Post-translational modificationHydrolase0.0000001124Least InformativeDirect
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationReceptor0.00000000003893Moderately InformativeDirect
Post-translational modificationRepressor0.0000005254Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.0001241Moderately InformativeDirect
Post-translational modificationSerine protease0InformativeDirect
Post-translational modificationChromatin regulator0.000000000006042InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a SRCR-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the SRCR-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]