SUPERFAMILY 1.75 HMM library and genome assignments server


SRCR-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   SRCR-like [ 56486] (2)
Superfamily:   SRCR-like [ 56487] (2)
Families:   Scavenger receptor cysteine-rich (SRCR) domain [ 56488]
  Hepsin, N-terminal domain [ 103355]


Superfamily statistics
Genomes (165) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 12,093 12,352 3
Proteins 4,136 4,183 3


Functional annotation
General category Regulation
Detailed category Receptor activity

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 7.027e-13 Least Informative Direct
Biological Process (BP) protein metabolic process 1.972e-11 Least Informative Direct
Biological Process (BP) multicellular organismal process 3.66e-07 Least Informative Direct
Biological Process (BP) response to stimulus 0.001183 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.1858 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.7711 Least Informative Inherited
Biological Process (BP) developmental process 0.01097 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.1444 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.03775 Least Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1.415e-07 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 6.672e-07 Moderately Informative Direct
Biological Process (BP) system process 1.001e-06 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 2.126e-06 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 4.657e-06 Moderately Informative Direct
Biological Process (BP) multi-organism process 8.757e-05 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.0006962 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0.6659 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.4668 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.1374 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.07963 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.07133 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.1739 Moderately Informative Inherited
Biological Process (BP) ion transport 0.04769 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.1588 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.1481 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.1431 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.02351 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.2118 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.01532 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.009467 Moderately Informative Inherited
Biological Process (BP) organ development 0.003501 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.6349 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.08908 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.001394 Moderately Informative Inherited
Biological Process (BP) metal ion transport 1.032e-11 Informative Direct
Biological Process (BP) proteolysis 2.267e-11 Informative Direct
Biological Process (BP) transmembrane transport 7.762e-08 Informative Direct
Biological Process (BP) positive regulation of protein metabolic process 9.086e-08 Informative Direct
Biological Process (BP) embryonic organ development 3.436e-07 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 5.126e-07 Informative Direct
Biological Process (BP) secretion by cell 4.415e-06 Informative Direct
Biological Process (BP) response to hormone stimulus 5.143e-05 Informative Direct
Biological Process (BP) sensory organ development 6.508e-05 Informative Direct
Biological Process (BP) embryonic morphogenesis 7.28e-05 Informative Direct
Biological Process (BP) positive regulation of developmental process 0.0001575 Informative Direct
Biological Process (BP) negative regulation of cell death 0.000182 Informative Direct
Biological Process (BP) regulation of growth 0.0002068 Informative Direct
Biological Process (BP) negative regulation of developmental process 0.0004759 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.0004955 Informative Direct
Biological Process (BP) single-organism behavior 0.0005044 Informative Direct
Biological Process (BP) regulation of cell proliferation 0.007392 Informative Inherited
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 0.2394 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.313 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.4251 Informative Inherited
Biological Process (BP) organ morphogenesis 0.01132 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.041 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.01458 Informative Inherited
Biological Process (BP) negative regulation of gene expression 0.08864 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.4851 Informative Inherited
Biological Process (BP) regulation of cell development 1 Informative Inherited
Biological Process (BP) response to inorganic substance 0.06349 Informative Inherited
Biological Process (BP) cardiovascular system development 0.003629 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.06144 Informative Inherited
Biological Process (BP) locomotion 0.01516 Informative Inherited
Biological Process (BP) cellular component movement 0.07934 Informative Inherited
Biological Process (BP) localization of cell 0.2547 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.008054 Informative Inherited
Biological Process (BP) regulation of cellular amine metabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of protein processing 0 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0 Highly Informative Direct
Biological Process (BP) modification of morphology or physiology of other organism involved in symbiotic interaction 3.627e-14 Highly Informative Direct
Biological Process (BP) positive regulation of epithelial cell proliferation 4.286e-14 Highly Informative Direct
Biological Process (BP) embryonic organ morphogenesis 1e-11 Highly Informative Direct
Biological Process (BP) cellular component disassembly 1.035e-11 Highly Informative Direct
Biological Process (BP) regulation of cellular ketone metabolic process 2.15e-11 Highly Informative Direct
Biological Process (BP) stem cell development 3.857e-11 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 6.838e-11 Highly Informative Direct
Biological Process (BP) regulation of multi-organism process 1.618e-10 Highly Informative Direct
Biological Process (BP) mesenchyme development 1.199e-09 Highly Informative Direct
Biological Process (BP) response to hypoxia 1.089e-08 Highly Informative Direct
Biological Process (BP) angiogenesis 8.698e-08 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic process 1.144e-07 Highly Informative Direct
Biological Process (BP) positive regulation of growth 2.073e-07 Highly Informative Direct
Biological Process (BP) learning or memory 4.138e-07 Highly Informative Direct
Biological Process (BP) protein processing 4.177e-07 Highly Informative Direct
Biological Process (BP) regulation of organ morphogenesis 1.267e-06 Highly Informative Direct
Biological Process (BP) ear development 1.741e-06 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 1.027e-05 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 1.996e-05 Highly Informative Direct
Biological Process (BP) negative regulation of transcription, DNA-dependent 0.000128 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 0.000165 Highly Informative Direct
Biological Process (BP) exocytosis 0.0001804 Highly Informative Direct
Biological Process (BP) sensory perception 0.000307 Highly Informative Direct
Biological Process (BP) monovalent inorganic cation transport 0.0003876 Highly Informative Direct
Molecular Function (MF) hydrolase activity 5.361e-05 Least Informative Direct
Molecular Function (MF) binding 0.4044 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0.0006364 Moderately Informative Direct
Molecular Function (MF) transporter activity 0.001025 Moderately Informative Inherited
Molecular Function (MF) peptidase activity 0 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 6.924e-10 Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 3.157e-08 Informative Direct
Molecular Function (MF) receptor activity 1.312e-05 Informative Direct
Molecular Function (MF) enzyme binding 0.004711 Informative Inherited
Molecular Function (MF) serine hydrolase activity 0 Highly Informative Direct
Molecular Function (MF) cation channel activity 5.012e-11 Highly Informative Direct
Molecular Function (MF) ion gated channel activity 8.842e-11 Highly Informative Direct
Molecular Function (MF) transcription factor binding transcription factor activity 0.002255 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.1829 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.6861 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) extracellular region part 6.945e-11 Moderately Informative Direct
Cellular Component (CC) endomembrane system 2.075e-09 Moderately Informative Direct
Cellular Component (CC) vesicle 1.236e-07 Moderately Informative Direct
Cellular Component (CC) organelle membrane 8.095e-07 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 1.851e-06 Moderately Informative Direct
Cellular Component (CC) organelle envelope 7.663e-06 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.09105 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.02813 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 0.08829 Moderately Informative Inherited
Cellular Component (CC) extracellular matrix 0 Informative Direct
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) integral to membrane 1.852e-13 Informative Direct
Cellular Component (CC) nuclear envelope 1.145e-10 Informative Direct
Cellular Component (CC) cell junction 2.091e-07 Informative Direct
Cellular Component (CC) endoplasmic reticulum membrane 1.261e-05 Informative Direct
Cellular Component (CC) intrinsic to plasma membrane 7.59e-05 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 0.0005999 Informative Direct
Cellular Component (CC) secretory granule 0.03137 Informative Inherited
Cellular Component (CC) neuron projection 1 Informative Inherited
Cellular Component (CC) nuclear membrane 1.901e-14 Highly Informative Direct
Cellular Component (CC) extracellular matrix part 1.604e-12 Highly Informative Direct
Cellular Component (CC) cell body 1.535e-10 Highly Informative Direct
Cellular Component (CC) cytoplasmic vesicle membrane 5.723e-06 Highly Informative Direct
Cellular Component (CC) proteinaceous extracellular matrix 1.06e-05 Highly Informative Direct
Cellular Component (CC) integral to plasma membrane 6.034e-05 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)viral infectious disease0.1318InformativeInherited

Document: DO annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0.0001034Least InformativeDirect
Enzyme Commission (EC)Hydrolases0.0002113Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)6.211e-14Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH(2) group of donors0InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0InformativeDirect
Enzyme Commission (EC)With oxygen as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Enteropeptidase6.937e-11Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0.000129Moderately InformativeDirect
Biological processCell adhesion3.763e-12InformativeDirect
Biological processInflammatory response5.721e-10InformativeDirect
Biological processAcute phase2.9e-14Highly InformativeDirect
Cellular componentMembrane2.407e-08Least InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.0002844Moderately InformativeDirect
Cellular componentExtracellular matrix2.46e-10InformativeDirect
Cellular componentChromosome3.578e-09InformativeDirect
Cellular componentBasement membrane0.0002426Highly InformativeDirect
DomainSignal0Least InformativeDirect
DomainRepeat9.048e-14Least InformativeDirect
DomainTransmembrane0.0004525Least InformativeDirect
DomainSignal-anchor0InformativeDirect
DomainKringle0Highly InformativeDirect
DomainCollagen5.93e-10Highly InformativeDirect
Molecular functionCopper0InformativeDirect
Post-translational modificationHydrolase1.124e-07Least InformativeDirect
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationReceptor3.893e-11Moderately InformativeDirect
Post-translational modificationRepressor5.254e-07Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.0001241Moderately InformativeDirect
Post-translational modificationSerine protease0InformativeDirect
Post-translational modificationChromatin regulator6.042e-12InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a SRCR-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the SRCR-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]