SUPERFAMILY 1.75 HMM library and genome assignments server


SRCR-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   SRCR-like [ 56486] (2)
Superfamily:   SRCR-like [ 56487] (2)
Families:   Scavenger receptor cysteine-rich (SRCR) domain [ 56488]
  Hepsin, N-terminal domain [ 103355]


Superfamily statistics
Genomes (159) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 11,211 12,352 3
Proteins 3,874 4,183 3


Functional annotation
General category Regulation
Detailed category Receptor activity

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 0.000000000000196 Least Informative Direct
Biological Process (BP) protein metabolic process 0.000000000007276 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.0000001306 Least Informative Direct
Biological Process (BP) response to stimulus 0.001707 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.1872 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.7809 Least Informative Inherited
Biological Process (BP) developmental process 0.006706 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.2813 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.02288 Least Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.0000001274 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.0000005902 Moderately Informative Direct
Biological Process (BP) system process 0.000000897 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.000001541 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.000001565 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.00003638 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.0006792 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0.644 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.4797 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 0.1309 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.07097 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.6664 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.1596 Moderately Informative Inherited
Biological Process (BP) ion transport 0.04957 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.1382 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.144 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.1398 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.01304 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.1899 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.008092 Moderately Informative Inherited
Biological Process (BP) organ development 0.00346 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.527 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.6271 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.06803 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.001357 Moderately Informative Inherited
Biological Process (BP) metal ion transport 0.000000000006292 Informative Direct
Biological Process (BP) cellular component disassembly 0.000000000009047 Informative Direct
Biological Process (BP) proteolysis 0.00000000001579 Informative Direct
Biological Process (BP) transmembrane transport 0.00000008177 Informative Direct
Biological Process (BP) embryonic organ development 0.0000003593 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.0000005364 Informative Direct
Biological Process (BP) secretion by cell 0.000002954 Informative Direct
Biological Process (BP) response to hormone stimulus 0.0000449 Informative Direct
Biological Process (BP) sensory organ development 0.00006808 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.00006862 Informative Direct
Biological Process (BP) embryonic morphogenesis 0.00007254 Informative Direct
Biological Process (BP) negative regulation of cell death 0.000178 Informative Direct
Biological Process (BP) positive regulation of developmental process 0.0001949 Informative Direct
Biological Process (BP) regulation of growth 0.0001999 Informative Direct
Biological Process (BP) single-organism behavior 0.0003334 Informative Direct
Biological Process (BP) negative regulation of developmental process 0.0004669 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.0004949 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.2261 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.007592 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.3083 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.4207 Informative Inherited
Biological Process (BP) organ morphogenesis 0.01178 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.04119 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.01303 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.5037 Informative Inherited
Biological Process (BP) regulation of cell development 1 Informative Inherited
Biological Process (BP) response to inorganic substance 0.06314 Informative Inherited
Biological Process (BP) cardiovascular system development 0.003757 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.05654 Informative Inherited
Biological Process (BP) locomotion 0.01255 Informative Inherited
Biological Process (BP) cellular component movement 0.06745 Informative Inherited
Biological Process (BP) localization of cell 0.2556 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.008213 Informative Inherited
Biological Process (BP) regulation of cellular amine metabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of protein processing 0 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0 Highly Informative Direct
Biological Process (BP) positive regulation of epithelial cell proliferation 0.00000000000003095 Highly Informative Direct
Biological Process (BP) ion transmembrane transport 0.00000000000004889 Highly Informative Direct
Biological Process (BP) embryonic organ morphogenesis 0.000000000006765 Highly Informative Direct
Biological Process (BP) modification of morphology or physiology of other organism 0.000000000009668 Highly Informative Direct
Biological Process (BP) regulation of cellular ketone metabolic process 0.00000000001562 Highly Informative Direct
Biological Process (BP) stem cell development 0.00000000002084 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.00000000004232 Highly Informative Direct
Biological Process (BP) regulation of multi-organism process 0.000000000154 Highly Informative Direct
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.0000000002328 Highly Informative Direct
Biological Process (BP) inner ear development 0.0000000004805 Highly Informative Direct
Biological Process (BP) mesenchyme development 0.000000001111 Highly Informative Direct
Biological Process (BP) response to hypoxia 0.000000001736 Highly Informative Direct
Biological Process (BP) regulation of cell growth 0.00000000913 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic process 0.00000006759 Highly Informative Direct
Biological Process (BP) angiogenesis 0.00000009083 Highly Informative Direct
Biological Process (BP) learning or memory 0.0000002496 Highly Informative Direct
Biological Process (BP) positive regulation of growth 0.0000002639 Highly Informative Direct
Biological Process (BP) protein processing 0.0000003168 Highly Informative Direct
Biological Process (BP) regulation of organ morphogenesis 0.000001549 Highly Informative Direct
Biological Process (BP) positive regulation of cell differentiation 0.000003415 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0.00001234 Highly Informative Direct
Biological Process (BP) negative regulation of transcription, DNA-dependent 0.0000864 Highly Informative Direct
Biological Process (BP) exocytosis 0.0001643 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 0.0001679 Highly Informative Direct
Biological Process (BP) sensory perception 0.0003498 Highly Informative Direct
Biological Process (BP) monovalent inorganic cation transport 0.0003534 Highly Informative Direct
Molecular Function (MF) hydrolase activity 0.00005794 Least Informative Direct
Molecular Function (MF) binding 0.3216 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0.0005921 Moderately Informative Direct
Molecular Function (MF) transporter activity 0.0007771 Moderately Informative Direct
Molecular Function (MF) peptidase activity 0 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0.0000000004805 Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 0.00000002232 Informative Direct
Molecular Function (MF) receptor activity 0.000008516 Informative Direct
Molecular Function (MF) enzyme binding 0.003141 Informative Inherited
Molecular Function (MF) cation channel activity 0.00000000003541 Highly Informative Direct
Molecular Function (MF) ion gated channel activity 0.00000000006247 Highly Informative Direct
Molecular Function (MF) protein binding transcription factor activity 0.003036 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.15 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.5778 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.00000000001018 Moderately Informative Direct
Cellular Component (CC) endomembrane system 0.0000000008978 Moderately Informative Direct
Cellular Component (CC) vesicle 0.00000003809 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.0000009718 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 0.000001193 Moderately Informative Direct
Cellular Component (CC) organelle envelope 0.000005647 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.08207 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.02509 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 0.09974 Moderately Informative Inherited
Cellular Component (CC) extracellular matrix 0 Informative Direct
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) integral to membrane 0.0000000000001106 Informative Direct
Cellular Component (CC) nuclear envelope 0.0000000001147 Informative Direct
Cellular Component (CC) cell-cell junction 0.000000000818 Informative Direct
Cellular Component (CC) endoplasmic reticulum membrane 0.00001162 Informative Direct
Cellular Component (CC) intrinsic to plasma membrane 0.0000728 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 0.0002625 Informative Direct
Cellular Component (CC) secretory granule 0.03126 Informative Inherited
Cellular Component (CC) neuron projection 0.9943 Informative Inherited
Cellular Component (CC) nuclear membrane 0.0000000000000178 Highly Informative Direct
Cellular Component (CC) extracellular matrix part 0.0000000000006655 Highly Informative Direct
Cellular Component (CC) cell body 0.0000000001642 Highly Informative Direct
Cellular Component (CC) cytoplasmic vesicle membrane 0.000005558 Highly Informative Direct
Cellular Component (CC) proteinaceous extracellular matrix 0.00001297 Highly Informative Direct
Cellular Component (CC) integral to plasma membrane 0.00004653 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0.0001017Least InformativeDirect
Enzyme Commission (EC)Hydrolases0.0002031Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.00000000000006369Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH(2) group of donors0InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0InformativeDirect
Enzyme Commission (EC)With oxygen as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Enteropeptidase0.00000000006937Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0.000125Moderately InformativeDirect
Biological processCell adhesion0.00000000000379InformativeDirect
Biological processInflammatory response0.00000000054InformativeDirect
Biological processAcute phase0.00000000000002962Highly InformativeDirect
Cellular componentMembrane0.000000022Least InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.0002779Moderately InformativeDirect
Cellular componentExtracellular matrix0.0000000002563InformativeDirect
Cellular componentChromosome0.000000003612InformativeDirect
Cellular componentBasement membrane0.0002423Highly InformativeDirect
DomainSignal0Least InformativeDirect
DomainRepeat0.00000000000008794Least InformativeDirect
DomainTransmembrane0.0004413Least InformativeDirect
DomainSignal-anchor0InformativeDirect
DomainKringle0Highly InformativeDirect
DomainCollagen0.0000000006103Highly InformativeDirect
Molecular functionCopper0InformativeDirect
Post-translational modificationHydrolase0.0000001029Least InformativeDirect
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationReceptor0.00000000004009Moderately InformativeDirect
Post-translational modificationRepressor0.0000004714Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.0001262Moderately InformativeDirect
Post-translational modificationSerine protease0InformativeDirect
Post-translational modificationChromatin regulator0.000000000005657InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a SRCR-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the SRCR-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]