SUPERFAMILY 1.75 HMM library and genome assignments server

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SRCR-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   SRCR-like [ 56486] (2)
Superfamily:   SRCR-like [ 56487] (2)
Families:   Scavenger receptor cysteine-rich (SRCR) domain [ 56488]
  Hepsin, N-terminal domain [ 103355]


Superfamily statistics
Genomes (165) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 12,093 12,352 3
Proteins 4,136 4,183 3


Functional annotation
General category Regulation
Detailed category Receptor activity

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 0.0000000000005828 Least Informative Direct
Biological Process (BP) protein metabolic process 0.00000000001806 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.0000003577 Least Informative Direct
Biological Process (BP) response to stimulus 0.003775 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.1803 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.7665 Least Informative Inherited
Biological Process (BP) developmental process 0.01092 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.2754 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.03556 Least Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.0000001251 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.0000005906 Moderately Informative Direct
Biological Process (BP) system process 0.0000009267 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.000001721 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.000001759 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.00007567 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.0006901 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0.6554 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.4772 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.1441 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.08318 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.06969 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.1666 Moderately Informative Inherited
Biological Process (BP) ion transport 0.04864 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.1575 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.1467 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.1398 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.01596 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.2074 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.01459 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.00844 Moderately Informative Inherited
Biological Process (BP) organ development 0.003502 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.5303 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.6316 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.08825 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.00137 Moderately Informative Inherited
Biological Process (BP) metal ion transport 0.00000000001047 Informative Direct
Biological Process (BP) proteolysis 0.00000000001998 Informative Direct
Biological Process (BP) transmembrane transport 0.00000008239 Informative Direct
Biological Process (BP) embryonic organ development 0.0000003513 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.0000004892 Informative Direct
Biological Process (BP) secretion by cell 0.000003035 Informative Direct
Biological Process (BP) response to hormone stimulus 0.0000518 Informative Direct
Biological Process (BP) sensory organ development 0.0000642 Informative Direct
Biological Process (BP) embryonic morphogenesis 0.00007456 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.0001032 Informative Direct
Biological Process (BP) positive regulation of developmental process 0.0001563 Informative Direct
Biological Process (BP) negative regulation of cell death 0.0001894 Informative Direct
Biological Process (BP) regulation of growth 0.0002032 Informative Direct
Biological Process (BP) negative regulation of developmental process 0.0004527 Informative Direct
Biological Process (BP) single-organism behavior 0.0004786 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.0005417 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.2284 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.007309 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.311 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.4251 Informative Inherited
Biological Process (BP) organ morphogenesis 0.01126 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.04215 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.01317 Informative Inherited
Biological Process (BP) negative regulation of gene expression 0.09084 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.4895 Informative Inherited
Biological Process (BP) regulation of cell development 1 Informative Inherited
Biological Process (BP) response to inorganic substance 0.06268 Informative Inherited
Biological Process (BP) cardiovascular system development 0.003669 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.05941 Informative Inherited
Biological Process (BP) locomotion 0.01529 Informative Inherited
Biological Process (BP) cellular component movement 0.06585 Informative Inherited
Biological Process (BP) localization of cell 0.2588 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.008173 Informative Inherited
Biological Process (BP) regulation of cellular amine metabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of protein processing 0 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0 Highly Informative Direct
Biological Process (BP) positive regulation of epithelial cell proliferation 0.0000000000000444 Highly Informative Direct
Biological Process (BP) cellular component disassembly 0.000000000006657 Highly Informative Direct
Biological Process (BP) embryonic organ morphogenesis 0.000000000009614 Highly Informative Direct
Biological Process (BP) modification of morphology or physiology of other organism 0.00000000001339 Highly Informative Direct
Biological Process (BP) regulation of cellular ketone metabolic process 0.00000000002249 Highly Informative Direct
Biological Process (BP) stem cell development 0.00000000003781 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.00000000006636 Highly Informative Direct
Biological Process (BP) regulation of multi-organism process 0.0000000001405 Highly Informative Direct
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.0000000009671 Highly Informative Direct
Biological Process (BP) mesenchyme development 0.000000001217 Highly Informative Direct
Biological Process (BP) response to hypoxia 0.000000002376 Highly Informative Direct
Biological Process (BP) angiogenesis 0.00000008933 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic process 0.0000001096 Highly Informative Direct
Biological Process (BP) positive regulation of growth 0.0000001963 Highly Informative Direct
Biological Process (BP) learning or memory 0.0000003512 Highly Informative Direct
Biological Process (BP) protein processing 0.0000004025 Highly Informative Direct
Biological Process (BP) regulation of organ morphogenesis 0.00000144 Highly Informative Direct
Biological Process (BP) ear development 0.000001742 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0.00001072 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0.00002022 Highly Informative Direct
Biological Process (BP) negative regulation of transcription, DNA-dependent 0.0001221 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 0.0001552 Highly Informative Direct
Biological Process (BP) exocytosis 0.000171 Highly Informative Direct
Biological Process (BP) sensory perception 0.0003332 Highly Informative Direct
Biological Process (BP) monovalent inorganic cation transport 0.000381 Highly Informative Direct
Molecular Function (MF) hydrolase activity 0.00005455 Least Informative Direct
Molecular Function (MF) binding 0.3929 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0.0006137 Moderately Informative Direct
Molecular Function (MF) transporter activity 0.001043 Moderately Informative Inherited
Molecular Function (MF) peptidase activity 0 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0.0000000007001 Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 0.000000032 Informative Direct
Molecular Function (MF) receptor activity 0.00001325 Informative Direct
Molecular Function (MF) enzyme binding 0.004636 Informative Inherited
Molecular Function (MF) serine hydrolase activity 0 Highly Informative Direct
Molecular Function (MF) cation channel activity 0.00000000005121 Highly Informative Direct
Molecular Function (MF) ion gated channel activity 0.00000000009028 Highly Informative Direct
Molecular Function (MF) protein binding transcription factor activity 0.003755 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.1817 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.6805 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.00000000006777 Moderately Informative Direct
Cellular Component (CC) endomembrane system 0.0000000007488 Moderately Informative Direct
Cellular Component (CC) vesicle 0.0000001224 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.0000007992 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 0.000001804 Moderately Informative Direct
Cellular Component (CC) organelle envelope 0.000007599 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.09119 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.02651 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 0.09054 Moderately Informative Inherited
Cellular Component (CC) extracellular matrix 0 Informative Direct
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) integral to membrane 0.0000000000001878 Informative Direct
Cellular Component (CC) nuclear envelope 0.0000000001299 Informative Direct
Cellular Component (CC) cell junction 0.0000002108 Informative Direct
Cellular Component (CC) endoplasmic reticulum membrane 0.00001196 Informative Direct
Cellular Component (CC) intrinsic to plasma membrane 0.00007749 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 0.0006046 Informative Direct
Cellular Component (CC) secretory granule 0.03069 Informative Inherited
Cellular Component (CC) neuron projection 0.9956 Informative Inherited
Cellular Component (CC) nuclear membrane 0.00000000000001759 Highly Informative Direct
Cellular Component (CC) extracellular matrix part 0.000000000001293 Highly Informative Direct
Cellular Component (CC) cell body 0.0000000001552 Highly Informative Direct
Cellular Component (CC) cytoplasmic vesicle membrane 0.00000545 Highly Informative Direct
Cellular Component (CC) proteinaceous extracellular matrix 0.000008877 Highly Informative Direct
Cellular Component (CC) integral to plasma membrane 0.00005985 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)viral infectious disease0.1316InformativeInherited

Document: DO annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0.00009969Least InformativeDirect
Enzyme Commission (EC)Hydrolases0.0002124Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.00000000000006305Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH(2) group of donors0InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0InformativeDirect
Enzyme Commission (EC)With oxygen as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Enteropeptidase0.0000000000693Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0.0001243Moderately InformativeDirect
Biological processCell adhesion0.000000000003729InformativeDirect
Biological processInflammatory response0.0000000005353InformativeDirect
Biological processAcute phase0.0000000000000292Highly InformativeDirect
Cellular componentMembrane0.00000002312Least InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.0002764Moderately InformativeDirect
Cellular componentExtracellular matrix0.000000000248InformativeDirect
Cellular componentChromosome0.000000003574InformativeDirect
Cellular componentBasement membrane0.0002422Highly InformativeDirect
DomainSignal0Least InformativeDirect
DomainRepeat0.000000000000085Least InformativeDirect
DomainTransmembrane0.0004592Least InformativeDirect
DomainSignal-anchor0InformativeDirect
DomainKringle0Highly InformativeDirect
DomainCollagen0.000000000603Highly InformativeDirect
Molecular functionCopper0InformativeDirect
Post-translational modificationHydrolase0.0000001044Least InformativeDirect
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationReceptor0.00000000003919Moderately InformativeDirect
Post-translational modificationRepressor0.0000004742Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.0001251Moderately InformativeDirect
Post-translational modificationSerine protease0InformativeDirect
Post-translational modificationChromatin regulator0.000000000005569InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a SRCR-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the SRCR-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]