SUPERFAMILY 1.75 HMM library and genome assignments server


C-type lectin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   C-type lectin-like [ 56435]
Superfamily:   C-type lectin-like [ 56436] (8)
Families:   C-type lectin domain [ 56437] (28)
  Aerolysin/Pertussis toxin (APT) domain [ 56467] (2)
  Invasin/intimin cell-adhesion fragment, C-terminal domain [ 56472] (2)
  Link domain [ 56477] (2)
  Endostatin [ 56480] (2)
  Noncollagenous (NC1) domain of collagen IV [ 75585]
  Sulfatase-modifying factor-like [ 143959] (2)
  Mtd variable domain [ 143964]


Superfamily statistics
Genomes (1,254) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 23,368 28,663 125
Proteins 16,754 22,343 121


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism cellular process0.3550.7781Least InformativeInherited
Biological Process (BP)multicellular organismal process0.16849.287e-10Least InformativeInherited
Biological Process (BP)multi-organism process0.0002060.0009252Moderately InformativeDirect
Biological Process (BP)immune system process0.00071334.455e-09Moderately InformativeDirect
Biological Process (BP)biological adhesion1.467e-110InformativeDirect
Biological Process (BP)cell adhesion8.889e-120Highly InformativeDirect
Biological Process (BP)ossification0.00012916.427e-08Highly InformativeDirect
Molecular Function (MF)binding2.945e-110Least InformativeDirect
Molecular Function (MF)receptor activity6.015e-080InformativeDirect
Molecular Function (MF)monosaccharide binding10.5523Highly InformativeInherited
Cellular Component (CC)membrane0.0010830Least InformativeInherited
Cellular Component (CC)extracellular region1.154e-070Moderately InformativeDirect
Cellular Component (CC)plasma membrane2.181e-050Moderately InformativeDirect
Cellular Component (CC)cell surface2.028e-120InformativeDirect
Cellular Component (CC)extracellular matrix7.259e-050InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 8.447e-06 Least Informative Direct
Biological Process (BP) multicellular organismal process 9.287e-10 Least Informative Direct
Biological Process (BP) developmental process 6.858e-06 Least Informative Direct
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.7781 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) multi-organism process 0.0009252 Moderately Informative Direct
Biological Process (BP) immune system process 4.455e-09 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0.0002704 Moderately Informative Direct
Biological Process (BP) regulation of localization 1.91e-05 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 0.0001983 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.8155 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.2616 Moderately Informative Inherited
Biological Process (BP) reproduction 0.6527 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.5272 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.8226 Moderately Informative Inherited
Biological Process (BP) organ development 0.09948 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.2307 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.9915 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.1817 Moderately Informative Inherited
Biological Process (BP) biological adhesion 0 Informative Direct
Biological Process (BP) defense response 4.008e-15 Informative Direct
Biological Process (BP) regulation of immune response 4.117e-09 Informative Direct
Biological Process (BP) response to wounding 2.794e-05 Informative Direct
Biological Process (BP) regulation of cytokine production 1.68e-10 Informative Direct
Biological Process (BP) positive regulation of transport 4.461e-10 Informative Direct
Biological Process (BP) positive regulation of immune system process 3.718e-08 Informative Direct
Biological Process (BP) regulation of response to stress 1.189e-06 Informative Direct
Biological Process (BP) cell activation 0.0004628 Informative Direct
Biological Process (BP) response to oxidative stress 0.09559 Informative Inherited
Biological Process (BP) regulation of protein localization 0.326 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.8778 Informative Inherited
Biological Process (BP) tube development 0.01604 Informative Inherited
Biological Process (BP) organ morphogenesis 1 Informative Inherited
Biological Process (BP) reproductive system development 0.9366 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) anatomical structure homeostasis 0.05683 Informative Inherited
Biological Process (BP) multicellular organismal homeostasis 0.1748 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.1837 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.9698 Informative Inherited
Biological Process (BP) regulation of cell development 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.4783 Informative Inherited
Biological Process (BP) locomotion 0.001587 Informative Inherited
Biological Process (BP) response to external stimulus 0.5347 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.001291 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.273 Informative Inherited
Biological Process (BP) response to organic nitrogen 0.3206 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) regulation of secretion 0.00114 Informative Inherited
Biological Process (BP) regulation of ion transport 0.09135 Informative Inherited
Biological Process (BP) cellular component disassembly 0.006596 Informative Inherited
Biological Process (BP) gland development 0.2165 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.5125 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 0.07188 Informative Inherited
Biological Process (BP) muscle structure development 0.6317 Informative Inherited
Biological Process (BP) muscle tissue development 0.2442 Informative Inherited
Biological Process (BP) generation of neurons 0.4426 Informative Inherited
Biological Process (BP) cell projection organization 0.02474 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.005702 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 0.482 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.9072 Informative Inherited
Biological Process (BP) immune response 0.003638 Informative Inherited
Biological Process (BP) immune effector process 0.9479 Informative Inherited
Biological Process (BP) cell adhesion 0 Highly Informative Direct
Biological Process (BP) ossification 6.427e-08 Highly Informative Direct
Biological Process (BP) regulation of cell killing 0 Highly Informative Direct
Biological Process (BP) regulation of lymphocyte mediated immunity 0 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 6.976e-14 Highly Informative Direct
Biological Process (BP) regulation of protein processing 3.99e-13 Highly Informative Direct
Biological Process (BP) multicellular organismal metabolic process 1.198e-07 Highly Informative Direct
Biological Process (BP) positive regulation of secretion 2.839e-07 Highly Informative Direct
Biological Process (BP) aminoglycan catabolic process 8.163e-07 Highly Informative Direct
Biological Process (BP) chemical homeostasis within a tissue 6.331e-06 Highly Informative Direct
Biological Process (BP) axonogenesis 8.484e-06 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 5.182e-05 Highly Informative Direct
Biological Process (BP) positive regulation of ion transport 8.201e-05 Highly Informative Direct
Biological Process (BP) morphogenesis of a branching epithelium 0.0001188 Highly Informative Direct
Biological Process (BP) glycosaminoglycan metabolic process 0.0004185 Highly Informative Direct
Biological Process (BP) muscle fiber development 0.0004857 Highly Informative Direct
Biological Process (BP) chemotaxis 0.0005829 Highly Informative Direct
Biological Process (BP) regulation of cytokine biosynthetic process 0.0006895 Highly Informative Direct
Biological Process (BP) positive regulation of immune effector process 0.0007895 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.00232 Highly Informative Inherited
Biological Process (BP) kidney development 0.01287 Highly Informative Inherited
Biological Process (BP) epithelial tube morphogenesis 0.001986 Highly Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 0.03501 Highly Informative Inherited
Biological Process (BP) regulation of protein secretion 0.005057 Highly Informative Inherited
Biological Process (BP) positive regulation of protein transport 0.2661 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.01785 Highly Informative Inherited
Biological Process (BP) regulation of myeloid cell differentiation 0.1873 Highly Informative Inherited
Biological Process (BP) regulation of innate immune response 0.01035 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.3045 Highly Informative Inherited
Biological Process (BP) regulation of angiogenesis 0.03226 Highly Informative Inherited
Biological Process (BP) aging 0.01637 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.08462 Highly Informative Inherited
Biological Process (BP) phagocytosis 0.005039 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.47 Highly Informative Inherited
Biological Process (BP) wound healing 0.02416 Highly Informative Inherited
Biological Process (BP) inflammatory response 0.001363 Highly Informative Inherited
Biological Process (BP) activation of immune response 0.01181 Highly Informative Inherited
Biological Process (BP) immune response-regulating signaling pathway 0.009324 Highly Informative Inherited
Biological Process (BP) humoral immune response 0.02594 Highly Informative Inherited
Biological Process (BP) innate immune response 1 Highly Informative Inherited
Biological Process (BP) protein activation cascade 0.001249 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) structural molecule activity 6.127e-05 Moderately Informative Direct
Molecular Function (MF) anion binding 0.5616 Moderately Informative Inherited
Molecular Function (MF) cation binding 0.08412 Moderately Informative Inherited
Molecular Function (MF) protein binding 1 Moderately Informative Inherited
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) receptor binding 0.0001468 Informative Direct
Molecular Function (MF) protein dimerization activity 2.254e-05 Informative Direct
Molecular Function (MF) molecular transducer activity 2.207e-08 Informative Direct
Molecular Function (MF) enzyme binding 0.009466 Informative Inherited
Molecular Function (MF) protein homodimerization activity 2.958e-05 Highly Informative Direct
Molecular Function (MF) calcium ion binding 3.086e-09 Highly Informative Direct
Molecular Function (MF) sulfur compound binding 2.151e-06 Highly Informative Direct
Molecular Function (MF) glycosaminoglycan binding 0.000308 Highly Informative Direct
Molecular Function (MF) monosaccharide binding 0.5523 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) extracellular region 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 1 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.08534 Moderately Informative Inherited
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) extracellular matrix 0 Informative Direct
Cellular Component (CC) synapse 0.652 Informative Inherited
Cellular Component (CC) integral to membrane 0.02595 Informative Inherited
Cellular Component (CC) intrinsic to plasma membrane 0.8844 Informative Inherited
Cellular Component (CC) proteinaceous extracellular matrix 0 Highly Informative Direct
Cellular Component (CC) external side of plasma membrane 0 Highly Informative Direct
Cellular Component (CC) integral to plasma membrane 1.234e-06 Highly Informative Direct
Cellular Component (CC) extracellular matrix part 0 Highly Informative Direct
Cellular Component (CC) nucleolar part 4.002e-10 Highly Informative Direct
Cellular Component (CC) neuromuscular junction 0.0001289 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details) Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease by infectious agent0.003167Moderately InformativeInherited
Disease Ontology (DO)kidney disease0.006926Moderately InformativeInherited
Disease Ontology (DO)lung disease0.01912Moderately InformativeInherited
Disease Ontology (DO)nephritis0.03328InformativeInherited
Disease Ontology (DO)opportunistic mycosis0.0004972Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.07433Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.523Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the anterior segment of the eye0.06307Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the urinary system0.3077Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lens0.004069InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper urinary tract0.07205InformativeInherited
Phenotypic Abnormality (PA)Anterior lenticonus1.175e-08Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal renal physiology0.01563Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype3.192e-05Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.349Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.3842Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype1Least InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to infection1.852e-06Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal protein level1.384e-05Moderately InformativeDirect
Mammalian Phenotype (MP)renal/urinary system phenotype0.116Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.2652Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell-mediated immunity0.7732Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive immunity0.804Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune cell physiology0.8472Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.9353Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell migration0.01286InformativeInherited
Mammalian Phenotype (MP)other phenotype0.09799InformativeInherited
Mammalian Phenotype (MP)abnormal renal corpuscle morphology0.2478InformativeInherited
Mammalian Phenotype (MP)hemorrhage0.3102InformativeInherited
Mammalian Phenotype (MP)skin hemorrhage0.0005336Highly InformativeDirect
Mammalian Phenotype (MP)other aberrant phenotype0.04474Highly InformativeInherited
Mammalian Phenotype (MP)abnormal granulocyte physiology0.07809Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cellular extravasation0.1264Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism segment morphology variant1Moderately InformativeInherited

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0.0001305Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases3.867e-05Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase1.419e-08InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell adhesion0InformativeDirect
Biological processEndocytosis0InformativeDirect
Biological processInflammatory response0InformativeDirect
Biological processInnate immunity5.43e-06InformativeDirect
Biological processCytolysis9.264e-05InformativeDirect
Biological processAngiogenesis0.0002113InformativeDirect
Biological processAcute phase2.541e-11Highly InformativeDirect
Biological processHemolysis1.225e-05Highly InformativeDirect
Biological processAdaptive immunity1.25e-05Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentExtracellular matrix0InformativeDirect
Coding sequence diversityPolymorphism6.407e-05Moderately InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane9.914e-05Least InformativeDirect
DomainSignal-anchor0Moderately InformativeDirect
DomainEGF-like domain0InformativeDirect
DomainImmunoglobulin domain1.23e-07InformativeDirect
DomainCollagen0Highly InformativeDirect
DomainSushi0Highly InformativeDirect
DomainLaminin EGF-like domain2.433e-10Highly InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionLectin0InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationToxin0InformativeDirect
Post-translational modificationAntimicrobial0.002979InformativeInherited
Post-translational modificationHemostasis impairing toxin0Highly InformativeDirect
Post-translational modificationAntibiotic0.0001915Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationHydroxylation0InformativeDirect
Post-translational modificationProteoglycan0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0.001205Least InformativeInherited

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 72 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a C-type lectin-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 72 hidden Markov models representing the C-type lectin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]