SUPERFAMILY 1.75 HMM library and genome assignments server


ADP-ribosylation superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   ADP-ribosylation [ 56398]
Superfamily:   ADP-ribosylation [ 56399] (7)
Families:   ADP-ribosylating toxins [ 56400] (9)
  Ecto-ART [ 82814]
  Poly(ADP-ribose) polymerase, C-terminal domain [ 56416]
  AvrPphF ORF2, a type III effector [ 111257]
  Tpt1/KptA [ 118162]
  BC2332-like [ 143947]
  CC0527-like [ 143950]


Superfamily statistics
Genomes (1,370) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 7,267 15,580 57
Proteins 7,160 15,407 54


Functional annotation
General category Metabolism
Detailed category Secondary metabolism

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)protein metabolic process0.54650.1697Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.21488.19e-10Least InformativeInherited
Biological Process (BP)biosynthetic process0.7630.002976Least InformativeInherited
Biological Process (BP)carbohydrate metabolic process0.072362.43e-12Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process0.12715.061e-10Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process0.054822.571e-07Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.13763.704e-07Moderately InformativeInherited
Biological Process (BP)protein glycosylation3.568e-050Highly InformativeDirect
Molecular Function (MF)hydrolase activity0.65081Least InformativeInherited
Molecular Function (MF)transferase activity0.0027391.071e-12Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on glycosyl bonds0.00090421.462e-05InformativeDirect
Molecular Function (MF)transferase activity, transferring glycosyl groups0.0021390InformativeInherited
Molecular Function (MF)transferase activity, transferring pentosyl groups0.00080060Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0.0002208 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.0002298 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 8.19e-10 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.0001373 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.0001137 Least Informative Direct
Biological Process (BP) biosynthetic process 0.002976 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.7692 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.9464 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.1697 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.3592 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 2.43e-12 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 3.704e-07 Moderately Informative Direct
Biological Process (BP) cellular response to stress 6.292e-11 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 2.571e-07 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 5.061e-10 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.03252 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.1812 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.3022 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.501 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.03206 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.02373 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.04284 Moderately Informative Inherited
Biological Process (BP) DNA metabolic process 4.905e-10 Informative Direct
Biological Process (BP) response to DNA damage stimulus 5.981e-08 Informative Direct
Biological Process (BP) protein localization to organelle 0.0003964 Informative Direct
Biological Process (BP) chromosome organization 6.518e-07 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.01549 Informative Inherited
Biological Process (BP) regulation of growth 0.00358 Informative Inherited
Biological Process (BP) response to oxidative stress 0.001175 Informative Inherited
Biological Process (BP) response to inorganic substance 0.003284 Informative Inherited
Biological Process (BP) response to superoxide 1.3e-13 Highly Informative Direct
Biological Process (BP) double-strand break repair 8.416e-06 Highly Informative Direct
Biological Process (BP) protein glycosylation 0 Highly Informative Direct
Biological Process (BP) cellular response to reactive oxygen species 1.993e-06 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 1.541e-05 Highly Informative Direct
Molecular Function (MF) transferase activity 1.071e-12 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 0 Informative Direct
Molecular Function (MF) hydrolase activity, acting on glycosyl bonds 1.462e-05 Informative Direct
Molecular Function (MF) transferase activity, transferring pentosyl groups 0 Highly Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.001666 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.138 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.8008 Least Informative Inherited
Cellular Component (CC) intrinsic to membrane 0.1338 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.04177 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.03142 Moderately Informative Inherited
Cellular Component (CC) chromosome 0.1024 Informative Inherited
Cellular Component (CC) anchored to membrane 8.597e-07 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0.0003869Moderately InformativeDirect
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0InformativeDirect
Enzyme Commission (EC)1-phosphatidylinositol 4-kinase2.686e-11Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0.4572Least InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.06103Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system physiology0.1567Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal response to radiation4.24e-05InformativeDirect
Mammalian Phenotype (MP)abnormal female reproductive system physiology0.01647InformativeInherited
Mammalian Phenotype (MP)abnormal sensitivity to induced morbidity/mortality0.03113InformativeInherited
Mammalian Phenotype (MP)abnormal fertility/fecundity0.1116InformativeInherited
Mammalian Phenotype (MP)increased mortality induced by ionizing radiation3.619e-05Highly InformativeDirect
Mammalian Phenotype (MP)reduced fertility0.01273Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0.0003826Moderately InformativeDirect
Enzyme Commission (EC)Pentosyltransferases0InformativeDirect
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processVirulence1.209e-08InformativeDirect
Cellular componentNucleus3.239e-16Least InformativeDirect
Cellular componentMembrane0.725Least InformativeInherited
Cellular componentSecreted4.913e-05Moderately InformativeDirect
Cellular componentGolgi apparatus8.047e-05Moderately InformativeDirect
Cellular componentGPI-anchor6.428e-16InformativeDirect
DomainSignal2.879e-05Least InformativeDirect
DomainZinc-finger0.0002091Moderately InformativeDirect
DomainANK repeat0.0001261InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionNADP3.331e-10InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationGlycosyltransferase0InformativeDirect
Post-translational modificationToxin0InformativeDirect
Post-translational modificationADP-ribosylation0InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 22 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a ADP-ribosylation domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 22 hidden Markov models representing the ADP-ribosylation superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]