SUPERFAMILY 1.75 HMM library and genome assignments server

ADP-ribosylation superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   ADP-ribosylation [ 56398]
Superfamily:   ADP-ribosylation [ 56399] (7)
Families:   ADP-ribosylating toxins [ 56400] (9)
  Ecto-ART [ 82814]
  Poly(ADP-ribose) polymerase, C-terminal domain [ 56416]
  AvrPphF ORF2, a type III effector [ 111257]
  Tpt1/KptA [ 118162]
  BC2332-like [ 143947]
  CC0527-like [ 143950]


Superfamily statistics
Genomes (1,371) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 7,431 15,580 57
Proteins 7,319 15,407 54


Functional annotation
General category Metabolism
Detailed category Secondary metabolism

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)protein metabolic process0.56090.1774Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.21660.0000000009141Least InformativeInherited
Biological Process (BP)single-organism metabolic process10.00000009549Least InformativeInherited
Biological Process (BP)single-organism cellular process10.3666Least InformativeInherited
Biological Process (BP)biosynthetic process0.76410.002378Least InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process0.14470.000000001032Moderately InformativeInherited
Biological Process (BP)carbohydrate metabolic process0.07460.000000000002253Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process0.054890.0000002486Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.13920.0000004488Moderately InformativeInherited
Biological Process (BP)protein glycosylation0.00003530Highly InformativeDirect
Molecular Function (MF)hydrolase activity0.65131Least InformativeInherited
Molecular Function (MF)transferase activity0.0041370.00000000004131Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on glycosyl bonds0.00092430.00001567InformativeDirect
Molecular Function (MF)transferase activity, transferring glycosyl groups0.0016380InformativeInherited
Molecular Function (MF)transferase activity, transferring pentosyl groups0.00077730Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0.000231 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.0002295 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.0000000009141 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.00000009549 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.000143 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.0001219 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.8576 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.3658 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.1774 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.3666 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.002378 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.000000000002253 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.0000004488 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.00000000008826 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 0.0000002486 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.000000001032 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.04668 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.2086 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.0344 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.2977 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.5346 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.009648 Moderately Informative Inherited
Biological Process (BP) single-organism organelle organization 0.004318 Moderately Informative Inherited
Biological Process (BP) DNA repair 0 Informative Direct
Biological Process (BP) protein localization to organelle 0.0004591 Informative Direct
Biological Process (BP) chromosome organization 0.0000006505 Informative Direct
Biological Process (BP) anatomical structure homeostasis 0.000000000001897 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.01625 Informative Inherited
Biological Process (BP) response to inorganic substance 0.003405 Informative Inherited
Biological Process (BP) regulation of growth 0.003403 Informative Inherited
Biological Process (BP) response to oxidative stress 0.001428 Informative Inherited
Biological Process (BP) response to superoxide 0.0000000000001485 Highly Informative Direct
Biological Process (BP) double-strand break repair 0.000009754 Highly Informative Direct
Biological Process (BP) protein glycosylation 0 Highly Informative Direct
Biological Process (BP) cellular response to reactive oxygen species 0.000002142 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 0.0000272 Highly Informative Direct
Molecular Function (MF) transferase activity 0.00000000004131 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 0 Informative Direct
Molecular Function (MF) hydrolase activity, acting on glycosyl bonds 0.00001567 Informative Direct
Molecular Function (MF) transferase activity, transferring pentosyl groups 0 Highly Informative Direct
Cellular Component (CC) intracellular organelle part 0.1268 Least Informative Inherited
Cellular Component (CC) membrane 0.9178 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.003091 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.5615 Least Informative Inherited
Cellular Component (CC) intrinsic component of membrane 0.1472 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.02981 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.01196 Moderately Informative Inherited
Cellular Component (CC) chromosome 0.08426 Informative Inherited
Cellular Component (CC) anchored component of membrane 0.0000006038 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0.0003869Moderately InformativeDirect
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0InformativeDirect
Enzyme Commission (EC)1-phosphatidylinositol 4-kinase0.00000000002686Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0.4607Least InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.06356Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system physiology0.1555Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal response to radiation0.00004291InformativeDirect
Mammalian Phenotype (MP)abnormal female reproductive system physiology0.01586InformativeInherited
Mammalian Phenotype (MP)abnormal sensitivity to induced morbidity/mortality0.03178InformativeInherited
Mammalian Phenotype (MP)abnormal fertility/fecundity0.1109InformativeInherited
Mammalian Phenotype (MP)increased mortality induced by ionizing radiation0.00003657Highly InformativeDirect
Mammalian Phenotype (MP)reduced fertility0.01257Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0.0003805Moderately InformativeDirect
Enzyme Commission (EC)Pentosyltransferases0InformativeDirect
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processVirulence0.00000001205InformativeDirect
Cellular componentNucleus6.436e-16Least InformativeDirect
Cellular componentMembrane0.729Least InformativeInherited
Cellular componentSecreted0.00004892Moderately InformativeDirect
Cellular componentGolgi apparatus0.00008282Moderately InformativeDirect
Cellular componentGPI-anchor6.436e-16InformativeDirect
DomainSignal0.00002842Least InformativeDirect
DomainZinc-finger0.0002055Moderately InformativeDirect
DomainANK repeat0.0001246InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionNADP0.0000000003205InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationGlycosyltransferase0InformativeDirect
Post-translational modificationToxin0InformativeDirect
Post-translational modificationADP-ribosylation0InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 22 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a ADP-ribosylation domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 22 hidden Markov models representing the ADP-ribosylation superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]