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ADP-ribosylation superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   ADP-ribosylation [ 56398]
Superfamily:   ADP-ribosylation [ 56399] (7)
Families:   ADP-ribosylating toxins [ 56400] (9)
  Ecto-ART [ 82814]
  Poly(ADP-ribose) polymerase, C-terminal domain [ 56416]
  AvrPphF ORF2, a type III effector [ 111257]
  Tpt1/KptA [ 118162]
  BC2332-like [ 143947]
  CC0527-like [ 143950]


Superfamily statistics
Genomes (1,370) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 7,267 15,580 57
Proteins 7,160 15,407 54


Functional annotation
General category Metabolism
Detailed category Secondary metabolism

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)protein metabolic process0.54770.1725Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.21560.0000000008176Least InformativeInherited
Biological Process (BP)biosynthetic process0.76510.003005Least InformativeInherited
Biological Process (BP)carbohydrate metabolic process0.072520.000000000002459Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process0.13110.0000000005326Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process0.054660.0000002527Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.13830.0000003827Moderately InformativeInherited
Biological Process (BP)protein glycosylation0.000035630Highly InformativeDirect
Molecular Function (MF)hydrolase activity0.651Least InformativeInherited
Molecular Function (MF)transferase activity0.0027490.000000000001065Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on glycosyl bonds0.00090010.00001474InformativeDirect
Molecular Function (MF)transferase activity, transferring glycosyl groups0.0022110InformativeInherited
Molecular Function (MF)transferase activity, transferring pentosyl groups0.00077110Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0.0002221 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.0002311 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.0000000008176 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.0001375 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.0001145 Least Informative Direct
Biological Process (BP) biosynthetic process 0.003005 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.7848 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.9514 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.1725 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.3663 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.000000000002459 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.0000003827 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.00000000007592 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 0.0000002527 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.0000000005326 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.03439 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.1873 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.3028 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.5063 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.01031 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.0242 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.04489 Moderately Informative Inherited
Biological Process (BP) DNA metabolic process 0.0000000004681 Informative Direct
Biological Process (BP) response to DNA damage stimulus 0.00000005232 Informative Direct
Biological Process (BP) protein localization to organelle 0.0004091 Informative Direct
Biological Process (BP) chromosome organization 0.0000006446 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.01602 Informative Inherited
Biological Process (BP) regulation of growth 0.003732 Informative Inherited
Biological Process (BP) response to oxidative stress 0.00125 Informative Inherited
Biological Process (BP) response to inorganic substance 0.003345 Informative Inherited
Biological Process (BP) response to superoxide 0.0000000000001457 Highly Informative Direct
Biological Process (BP) double-strand break repair 0.000009471 Highly Informative Direct
Biological Process (BP) protein glycosylation 0 Highly Informative Direct
Biological Process (BP) cellular response to reactive oxygen species 0.00000217 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 0.00001535 Highly Informative Direct
Molecular Function (MF) transferase activity 0.000000000001065 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 0 Informative Direct
Molecular Function (MF) hydrolase activity, acting on glycosyl bonds 0.00001474 Informative Direct
Molecular Function (MF) transferase activity, transferring pentosyl groups 0 Highly Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.001666 Least Informative Inherited
Cellular Component (CC) membrane 0.92 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.139 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.6521 Least Informative Inherited
Cellular Component (CC) intrinsic to membrane 0.133 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.06556 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.03087 Moderately Informative Inherited
Cellular Component (CC) chromosome 0.1029 Informative Inherited
Cellular Component (CC) anchored to membrane 0.000000807 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0.0003869Moderately InformativeDirect
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0InformativeDirect
Enzyme Commission (EC)1-phosphatidylinositol 4-kinase0.00000000002686Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0.4607Least InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.06356Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system physiology0.1555Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal response to radiation0.00004291InformativeDirect
Mammalian Phenotype (MP)abnormal female reproductive system physiology0.01586InformativeInherited
Mammalian Phenotype (MP)abnormal sensitivity to induced morbidity/mortality0.03178InformativeInherited
Mammalian Phenotype (MP)abnormal fertility/fecundity0.1109InformativeInherited
Mammalian Phenotype (MP)increased mortality induced by ionizing radiation0.00003657Highly InformativeDirect
Mammalian Phenotype (MP)reduced fertility0.01257Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0.0003805Moderately InformativeDirect
Enzyme Commission (EC)Pentosyltransferases0InformativeDirect
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processVirulence0.00000001205InformativeDirect
Cellular componentNucleus6.436e-16Least InformativeDirect
Cellular componentMembrane0.729Least InformativeInherited
Cellular componentSecreted0.00004892Moderately InformativeDirect
Cellular componentGolgi apparatus0.00008282Moderately InformativeDirect
Cellular componentGPI-anchor6.436e-16InformativeDirect
DomainSignal0.00002842Least InformativeDirect
DomainZinc-finger0.0002055Moderately InformativeDirect
DomainANK repeat0.0001246InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionNADP0.0000000003205InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationGlycosyltransferase0InformativeDirect
Post-translational modificationToxin0InformativeDirect
Post-translational modificationADP-ribosylation0InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 22 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a ADP-ribosylation domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 22 hidden Markov models representing the ADP-ribosylation superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]